Nitratiruptor sp. SB155-2, complete genome NC_009662 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 152991093 Common proC pyrroline-5-carboxylate reductase NIS_1350 212 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 152990062 Common fabG 3-oxoacyl-[acyl-carrier-protein] reductase NIS_0313 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152990289 Common fabZ 3R-hydroxymyristoyl ACP dehydrase NIS_0540 187 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 152991316 Common - hypothetical protein NIS_1574 62 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 152989824 Common - multiple antibiotic transporter, MarC family NIS_0072 106 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 152990385 Common - hypothetical protein NIS_0636 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152990592 Nonpathogen - hypothetical protein NIS_0845 1 None None None 152991347 Common - HAD-superfamily hydrolase NIS_1606 166 COG0546 Gph, Predicted phosphatases General function prediction only 152990129 Common clpA ATP-dependent Clp protease, ATP-binding subunit ClpA NIS_0380 247 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 152991397 Common - hypothetical protein NIS_1656 7 None None None 152991373 Common - thioredoxin family protein NIS_1632 44 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 152990147 Common plsX fatty acid/phospholipid synthesis protein PlsX NIS_0398 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 152989853 Common - dephospho-CoA kinase NIS_0101 210 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 152990098 Common - Mn2+/Zn2+ ABC transporter, ATP-binding protein NIS_0349 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 152991243 Common trmD tRNA (guanine-N1-)-methyltransferase NIS_1501 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 152991491 Common - phosphate:Na+ symporter NIS_1751 74 COG1283 NptA, Na+/phosphate symporter Inorganic ion transport and metabolism 152989777 Common - metal ion ABC transporter, substrate-binding protein NIS_0024 154 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 152991063 Common - hypothetical protein NIS_1320 6 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 152990362 Common flgI flagellar P-ring protein FlgI NIS_0613 105 COG1706 FlgI, Flagellar basal-body P-ring protein Cell motility and secretion 152990229 Nonpathogen - hypothetical protein NIS_0480 1 None None None 152990494 Nonpathogen - hypothetical protein NIS_0747 1 None None None 152991428 Common - hypothetical protein NIS_1687 22 None None None 152990527 Common - hypothetical protein NIS_0780 7 COG1934 COG1934, Uncharacterized protein conserved in bacteria Function unknown 152990019 Common rpsL 30S ribosomal protein S12 NIS_0270 227 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 152990222 Nonpathogen - hypothetical protein NIS_0473 2 None None None 152990546 Common - soluble lytic murein transglycosylase NIS_0799 103 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 152990348 Common - hypothetical protein NIS_0599 121 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152990378 Common - flagellar basal body-associated protein FliL NIS_0629 52 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 152991522 Common - ABC transporter, ATP-binding protein NIS_1782 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 152990240 Common - hypothetical protein NIS_0491 5 None None None 152991078 Common - hypothetical protein NIS_1335 105 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 152991291 Common trxB thioredoxin reductase NIS_1549 245 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 152991421 Common - hypothetical protein NIS_1680 28 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 152991444 Common - type I restriction-modification system, R subunit NIS_1703 139 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 152991475 Common - thioredoxin reductase NIS_1734 94 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 152990133 Common rplY 50S ribosomal protein L25 NIS_0384 153 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 152990953 Common pfs 5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase NIS_1209 90 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 152989913 Common folE GTP cyclohydrolase I NIS_0163 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 152990254 Common - copper resistance protein A NIS_0505 113 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 152990561 Common - hypothetical protein NIS_0814 51 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 152990717 Common - transposase NIS_0972 4 None None None 152989947 Common - hypothetical protein NIS_0198 8 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 152991026 Common - competence/damage-inducible protein NIS_1283 191 COG1546 CinA, Uncharacterized protein (competence- and mitomycin-induced) General function prediction only 152990550 Nonpathogen - hypothetical protein NIS_0803 1 None None None 152990287 Common - glutamine-dependent NAD+ synthetase NIS_0538 190 COG0171 NadE, NAD synthase Coenzyme metabolism 152990984 Nonpathogen - hypothetical protein NIS_1240 11 None None None 152990811 Nonpathogen - hypothetical protein NIS_1066 5 None None None 152991215 Common - ATP-dependent DNA helicase, UvrD/REP family NIS_1473 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 152990559 Common lpxD UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase NIS_0812 179 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 152990009 Common tufA translation elongation factor Tu NIS_0260 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 152991538 Common - transcriptional regulator, Crp/Fnr family NIS_1798 140 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 152990328 Nonpathogen - hypothetical protein NIS_0579 1 None None None 152989888 Common rpsU 30S ribosomal protein S21 NIS_0138 10 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 152991386 Common accB acetyl-CoA carboxylase, biotin carboxyl carrier protein NIS_1645 172 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 152990996 Common - hypothetical protein NIS_1253 30 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152991002 Common wecB UDP-N-acetylglucosamine 2-epimerase NIS_1259 155 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 152989891 Common - cytochrome c peroxidase NIS_0141 93 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 152990476 Common leuB 3-isopropylmalate dehydrogenase NIS_0727 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 152990315 Common hisD histidinol dehydrogenase NIS_0566 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 152989830 Common - cation efflux system protein, CDF family NIS_0078 214 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 152990789 Common - aminotransferase NIS_1044 190 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 152990049 Common nuoL NADH-quinone oxidoreductase, chain L NIS_0300 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 152991171 Common - ammonium transporter NIS_1429 201 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 152990059 Common - sulfate transporter NIS_0310 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 152990635 Common htpX heat shock protein HtpX NIS_0888 192 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 152990276 Common - two-component response regulator NIS_0527 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152989970 Common - hypothetical protein NIS_0221 12 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 152990600 Common atpB F0F1-type ATP synthase, A subunit NIS_0853 206 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 152989769 Common - alkyl hydroperoxide reductase NIS_0016 213 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 152991133 Common - hypothetical protein NIS_1390 5 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 152991342 Common - autoinducer-2 production protein LuxS NIS_1601 55 COG1854 LuxS, LuxS protein involved in autoinducer AI2 synthesis Signal transduction mechanisms 152990783 Common - ABC transport system ATP-binding protein NIS_1038 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 152990314 Common - hypothetical protein NIS_0565 17 COG2515 Acd, 1-aminocyclopropane-1-carboxylate deaminase Amino acid transport and metabolism 152990664 Common - chemotaxis protein methyltransferase NIS_0918 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 152990373 Common fliF flagellar M-ring protein FliF NIS_0624 129 COG1766 FliF, Flagellar biosynthesis/type III secretory pathway lipoprotein Cell motility and secretion / Intracellular trafficking and secretion 152991452 Nonpathogen - hypothetical protein NIS_1711 1 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 152990420 Nonpathogen - hypothetical protein NIS_0671 2 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 152991571 Nonpathogen - sulfur oxidation protein SoxX NIS_1832 5 COG3474 COG3474, Cytochrome c2 Energy production and conversion 152991262 Common - glutathione-regulated potassium-efflux system protein NIS_1520 213 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 152990247 Common - diaminopimelate decarboxylase NIS_0498 217 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 152989905 Common - hypothetical protein NIS_0155 24 COG3137 COG3137, Putative salt-induced outer membrane protein Cell envelope biogenesis, outer membrane 152990706 Common - Ni-Fe hydrogenase, small subunit HupS NIS_0961 80 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 152990982 Common - hypothetical protein NIS_1238 53 COG3150 COG3150, Predicted esterase General function prediction only 152991160 Common - glycosyl transferase NIS_1418 94 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 152989812 Common - endonuclease III NIS_0060 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 152990579 Common - hypothetical protein NIS_0832 10 None None None 152991269 Common - hypothetical protein NIS_1527 9 COG5615 COG5615, Predicted integral membrane protein Function unknown 152990946 Common - hypothetical protein NIS_1202 7 None None None 152991590 Common - GTP-binding protein TypA NIS_1851 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 152991036 Common - thioredoxin NIS_1293 227 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 152991178 Common - ferredoxin--nitrite reductase NIS_1436 157 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 152990990 Common - sugar epimerase/dehydratase NIS_1247 189 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152991290 Common dapB dihydrodipicolinate reductase NIS_1548 216 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 152989839 Common - hypothetical protein NIS_0087 139 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 152991588 Common nfnB NAD(P)H-flavin oxidoreductase NIS_1849 104 COG0778 NfnB, Nitroreductase Energy production and conversion 152991183 Common - asparagine synthase, glutamine-hydrolyzing NIS_1441 149 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 152991331 Common - hypothetical protein NIS_1589 12 COG4378 COG4378, Uncharacterized protein conserved in bacteria Function unknown 152991225 Common - tRNA-i(6)A37 thiotransferase enzyme NIS_1483 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 152990044 Common nuoG NADH-quinone oxidoreductase, chain G NIS_0295 182 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 152990901 Nonpathogen - hypothetical protein NIS_1157 1 None None None 152990813 Common - molybdopterin oxidoreductase NIS_1068 167 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 152989768 Nonpathogen - hypothetical protein NIS_0015 7 COG1542 COG1542, Uncharacterized conserved protein Function unknown 152990882 Common - DNA polymerase III, delta' subunit NIS_1138 31 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 152990511 Common - transcriptional regulator NIS_0764 154 COG1959 COG1959, Predicted transcriptional regulator Transcription 152991045 Common - Na+-transporting oxaloacetate decarboxylase, beta subunit NIS_1302 56 COG1883 OadB, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit Energy production and conversion 152990291 Common clpX ATP-dependent Clp protease, ATP-binding subunit ClpX NIS_0542 234 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 152990500 Common - fibronectin, type III NIS_0753 20 COG3401 COG3401, Fibronectin type 3 domain-containing protein General function prediction only 152990701 Common - transcriptional regulator, MerR family NIS_0956 95 COG0789 SoxR, Predicted transcriptional regulators Transcription 152990355 Common fliG flagellar motor switch protein FliG NIS_0606 125 COG1536 FliG, Flagellar motor switch protein Cell motility and secretion 152990058 Common - carbonate dehydratase NIS_0309 154 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 152990915 Common - hypothetical protein NIS_1171 5 None None None 152990537 Common - amino acid transporter NIS_0790 181 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 152991280 Common - peroxiredoxin family protein NIS_1538 227 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 152991150 Common - CDP-diacylglycerol--serine O-phosphatidyltransferase NIS_1408 157 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 152991298 Common - hypothetical protein NIS_1556 5 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 152990113 Common hemN oxygen-independent coproporphyrinogen III oxidase NIS_0364 207 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 152990607 Common - hypothetical protein NIS_0860 45 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 152990873 Common - methyltransferase NIS_1129 57 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 152990298 Common metH 5-methyltetrahydrofolate--homocysteine methyltransferase NIS_0549 179 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 152990419 Common efp translation elongation factor P NIS_0670 218 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 152989963 Common rnhA ribonuclease HI NIS_0214 174 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 152991391 Common - hypothetical protein NIS_1650 5 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 152991169 Common pyrC dihydroorotase NIS_1427 90 COG0418 PyrC, Dihydroorotase Nucleotide transport and metabolism 152990089 Common rbn ribonuclease BN NIS_0340 118 COG1295 Rbn, Predicted membrane protein Function unknown 152991227 Common nusA transcription termination factor NusA NIS_1485 218 COG0195 NusA, Transcription elongation factor Transcription 152990082 Common - hypothetical protein NIS_0333 32 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 152991535 Common - nitric-oxide reductase, large subunit NIS_1795 101 COG3256 NorB, Nitric oxide reductase large subunit Inorganic ion transport and metabolism 152991541 Common - hypothetical protein NIS_1801 96 COG2202 AtoS, FOG: PAS/PAC domain Signal transduction mechanisms 152990026 Common - methyl-accepting chemotaxis protein NIS_0277 97 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152991210 Common - apolipoprotein N-acyltransferase NIS_1468 65 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 152990691 Common pgm phosphoglucomutase, alpha-D-glucose phosphate-specific NIS_0946 235 COG0033 Pgm, Phosphoglucomutase Carbohydrate transport and metabolism 152990478 Common purU formyltetrahydrofolate deformylase NIS_0729 217 COG0788 PurU, Formyltetrahydrofolate hydrolase Nucleotide transport and metabolism 152990432 Common - hypothetical protein NIS_0683 37 COG2203 FhlA, FOG: GAF domain Signal transduction mechanisms 152990753 Common - hypothetical protein NIS_1008 5 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 152990125 Common pyrB aspartate carbamoyltransferase, catalytic subunit NIS_0376 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 152990650 Common - hypothetical protein NIS_0904 11 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 152990415 Common - acriflavin resistance protein, AcrA/AcrE family NIS_0666 156 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 152989866 Common - outer membrane efflux protein NIS_0115 118 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 152989815 Common - arabinose-5-phosphate isomerase NIS_0063 165 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 152990074 Nonpathogen - hypothetical protein NIS_0325 2 None None None 152991414 Common - antimicrobial peptide ABC transporter, permease NIS_1673 182 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 152990855 Common - membrane-associated phospholipid phosphatase NIS_1111 17 COG3907 COG3907, PAP2 (acid phosphatase) superfamily protein General function prediction only 152990161 Common - hypothetical protein NIS_0412 9 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 152991480 Common - K+ transport system, NAD-binding component NIS_1740 122 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 152990936 Common - hypothetical protein NIS_1192 7 COG0730 COG0730, Predicted permeases General function prediction only 152990506 Common - DNA-directed RNA polymerase, omega subunit NIS_0759 7 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 152990842 Common ruvA holliday junction DNA helicase RuvA NIS_1098 211 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 152990964 Common atpD F0F1-type ATP synthase, beta subunit NIS_1220 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 152990548 Common - glutamyl-tRNA synthetase NIS_0801 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 152990444 Common - hypothetical protein NIS_0695 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 152991238 Common - twin-arginine translocation system protein, TatA/E family NIS_1496 13 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 152990183 Common trmU tRNA (5-methylaminomethyl-2-thiouridylate)- methyltransferase NIS_0434 215 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 152990767 Common - hypothetical protein NIS_1022 30 COG3030 FxsA, Protein affecting phage T7 exclusion by the F plasmid General function prediction only 152991042 Nonpathogen - hypothetical protein NIS_1299 3 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 152990406 Common argH argininosuccinate lyase NIS_0657 232 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 152990168 Common - hypothetical protein NIS_0419 7 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 152991007 Nonpathogen - hypothetical protein NIS_1264 5 None None None 152991156 Common - polysaccharide biosynthesis protein NIS_1414 36 COG3298 COG3298, Predicted 3'-5' exonuclease related to the exonuclease domain of PolB DNA replication, recombination, and repair 152991058 Common - aminotransferase NIS_1315 192 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 152989799 Common - hydrolase NIS_0046 111 COG0388 COG0388, Predicted amidohydrolase General function prediction only 152990175 Common - hypothetical protein NIS_0426 197 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152991417 Common - hypothetical protein NIS_1676 67 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 152990450 Common pyrD dihydroorotate dehydrogenase NIS_0701 227 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 152991408 Common cdsA phosphatidate cytidylyltransferase NIS_1667 215 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 152990808 Common - hypothetical protein NIS_1063 82 COG1565 COG1565, Uncharacterized conserved protein Function unknown 152990007 Common - transketolase NIS_0258 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 152990675 Common - hypothetical protein NIS_0929 45 COG3174 COG3174, Predicted membrane protein Function unknown 152990724 Common - hydrogenase expression/synthesis protein HypA NIS_0979 95 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 152990269 Common - hypothetical protein NIS_0520 84 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 152991114 Nonpathogen - nucleotidyltransferase NIS_1371 4 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 152990361 Common - flagellar L-ring protein FlgH NIS_0612 101 COG2063 FlgH, Flagellar basal body L-ring protein Cell motility and secretion 152990955 Common fabD malonyl CoA-acyl carrier protein transacylase NIS_1211 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 152991489 Common - [pyruvate formate-lyase]-activating enzyme NIS_1749 114 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 152991441 Common - hypothetical protein NIS_1700 12 None None None 152989855 Common - Bax protein NIS_0103 34 COG2992 Bax, Uncharacterized FlgJ-related protein General function prediction only 152991552 Common - hypothetical protein NIS_1812 27 None None None 152991220 Common - tRNA modifying enzyme NIS_1478 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 152990732 Common - dnaK suppressor protein DksA NIS_0987 39 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 152990838 Common - 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase NIS_1094 32 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152989754 Common dnaA chromosome replication initiator protein DnaA NIS_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 152990572 Common hup DNA-binding protein HU NIS_0825 210 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 152991168 Common - two-component response regulator NIS_1426 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152990241 Common - ammonium transporter NIS_0492 201 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 152990970 Common - chromosome partitioning protein ParB NIS_1226 185 COG1475 Spo0J, Predicted transcriptional regulators Transcription 152991252 Common - hypothetical protein NIS_1510 85 COG0327 COG0327, Uncharacterized conserved protein Function unknown 152990926 Common - hypothetical protein NIS_1182 190 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152990212 Nonpathogen - hypothetical protein NIS_0463 1 None None None 152991508 Common - N-acetyl-L-amino acid amidohydrolase NIS_1768 171 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 152989873 Common - hypothetical protein NIS_0123 36 COG1814 COG1814, Uncharacterized membrane protein Function unknown 152991437 Common - hypothetical protein NIS_1696 6 None None None 152989783 Common - transcriptional regulator, ArsR family NIS_0030 139 COG0640 ArsR, Predicted transcriptional regulators Transcription 152989933 Nonpathogen - hypothetical protein NIS_0184 1 None None None 152991306 Common - hypothetical protein NIS_1564 4 None None None 152991023 Common guaB inosine-5'-monophosphate dehydrogenase NIS_1280 244 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 152990481 Common glyS glycyl-tRNA synthetase, beta subunit NIS_0732 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 152991426 Nonpathogen - hypothetical protein NIS_1685 1 None None None 152990626 Common rnpA ribonuclease P protein component NIS_0879 43 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 152991157 Common - hypothetical protein NIS_1415 60 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 152990643 Common - hypothetical protein NIS_0896 50 COG1808 COG1808, Predicted membrane protein Function unknown 152989791 Nonpathogen - hypothetical protein NIS_0038 3 None None None 152991511 Common nrdD anaerobic ribonucleoside triphosphate reductase NIS_1771 105 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 152990745 Common hslV ATP-dependent protease HslVU, peptidase subunit HslV NIS_1000 149 COG5405 HslV, ATP-dependent protease HslVU (ClpYQ), peptidase subunit Posttranslational modification, protein turnover, chaperones 152991358 Common ccoO cytochrome c oxidase, cbb3-type, subunit II NIS_1617 82 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 152991129 Common gmd GDP-mannose 4,6-dehydratase NIS_1386 231 COG1089 Gmd, GDP-D-mannose dehydratase Cell envelope biogenesis, outer membrane 152991461 Common - multidrug-efflux transporter, MFS family NIS_1720 220 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152991195 Common - asparaginase NIS_1453 27 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 152990749 Common - hypothetical protein NIS_1004 4 None None None 152991457 Common - hypothetical protein NIS_1716 15 None None None 152990794 Common - HAD-superfamily hydrolase, subfamily IIA NIS_1049 107 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 152989841 Common - hypothetical protein NIS_0089 5 COG0701 COG0701, Predicted permeases General function prediction only 152990200 Nonpathogen - hypothetical protein NIS_0451 1 None None None 152990861 Common - hypothetical protein NIS_1117 106 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 152990207 Common - hypothetical protein NIS_0458 12 COG2932 COG2932, Predicted transcriptional regulator Transcription 152990064 Common fabF 3-oxoacyl-[acyl-carrier-protein] synthase I/II NIS_0315 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152989985 Common rpsN 30S ribosomal protein S14 NIS_0236 186 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 152990410 Common aroA 3-phosphoshikimate 1-carboxyvinyltransferase NIS_0661 229 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 152990199 Common - hypothetical protein NIS_0450 13 None None None 152989807 Common - ribosomal large subunit pseudouridine synthase, RluD subfamily NIS_0055 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 152990583 Common - fumarate/tartrate hydratase, alpha subunit NIS_0836 148 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 152991323 Common - hypothetical protein NIS_1581 93 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 152990899 Nonpathogen - hypothetical protein NIS_1155 2 None None None 152991065 Common - hypothetical protein NIS_1322 13 COG1241 MCM2, Predicted ATPase involved in replication control, Cdc46/Mcm family DNA replication, recombination, and repair 152991071 Common - transcriptional regulator NIS_1328 32 COG3311 AlpA, Predicted transcriptional regulator Transcription 152991365 Common - hypothetical protein NIS_1624 10 COG2952 COG2952, Uncharacterized protein conserved in bacteria Function unknown 152990303 Nonpathogen - hypothetical protein NIS_0554 3 None None None 152991287 Common - ribonuclease NIS_1545 21 COG3719 Rna, Ribonuclease I Translation, ribosomal structure and biogenesis 152990661 Common - signal transduction response regulator NIS_0915 179 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152990681 Common - hypothetical protein NIS_0935 76 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 152990891 Common - phosphohistidine phosphatase NIS_1147 15 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 152991528 Common - hypothetical protein NIS_1788 13 None None None 152990166 Common - peptidase, M23/M37 family NIS_0417 189 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 152990014 Common rplA 50S ribosomal protein L1 NIS_0265 247 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 152991466 Common - multidrug ABC transporter NIS_1725 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 152990574 Nonpathogen - hypothetical protein NIS_0827 11 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 152991446 Common - ATP-dependent DNA helicase NIS_1705 62 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 152989893 Common - hypothetical protein NIS_0143 11 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 152990994 Common - glycosyl transferase NIS_1251 192 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152990885 Common - (di)nucleoside polyphosphate hydrolase NIS_1141 123 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 152989911 Common - hypothetical protein NIS_0161 24 COG0694 COG0694, Thioredoxin-like proteins and domains Posttranslational modification, protein turnover, chaperones 152990282 Common - oligopeptidase A NIS_0533 126 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 152990267 Common - signal transduction response regulator NIS_0518 181 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152990521 Common - hydrolase, TatD family NIS_0774 239 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 152989949 Common - hypothetical protein NIS_0200 23 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 152990252 Nonpathogen - hypothetical protein NIS_0503 1 None None None 152990100 Common - peptidyl-arginine deiminase family protein NIS_0351 88 COG2957 COG2957, Peptidylarginine deiminase and related enzymes Amino acid transport and metabolism 152990370 Common - flagellar basal-body rod protein FlgB NIS_0621 53 COG1815 FlgB, Flagellar basal body protein Cell motility and secretion 152990012 Common nusG transcriptional antitermination factor NusG NIS_0263 215 COG0250 NusG, Transcription antiterminator Transcription 152990341 Common pgpA phosphatidylglycerophosphatase A NIS_0592 65 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 152989755 Common dnaN DNA polymerase III, beta subunit NIS_0002 214 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 152990533 Common - hypothetical protein NIS_0786 68 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 152991204 Common folC folylpolyglutamate synthase NIS_1462 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 152990999 Common - hypothetical protein NIS_1256 24 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 152990171 Common rbfA ribosome-binding factor A NIS_0422 13 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 152990563 Common - serine O-acetyltransferase NIS_0816 219 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 152990079 Common uvrB excinuclease ABC, B subunit NIS_0330 230 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 152990109 Common hemB porphobilinogen synthase NIS_0360 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 152990145 Common - hypothetical protein NIS_0396 7 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 152989775 Common - oxidoreductase NIS_0022 71 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 152990080 Common - hypothetical protein NIS_0331 2 None None None 152991043 Common - hypothetical protein NIS_1300 94 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 152990123 Common trpA tryptophan synthase, alpha chain NIS_0374 217 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 152990938 Common - tRNA-dihydrouridine synthase NIS_1194 215 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 152990002 Common murE UDP-N-acetylmuramoylananine-D-glutamate-2,6- diaminopimelate ligase NIS_0253 213 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 152990096 Common - hydrolase NIS_0347 198 COG0388 COG0388, Predicted amidohydrolase General function prediction only 152990980 Nonpathogen - hypothetical protein NIS_1236 2 COG4244 COG4244, Predicted membrane protein Function unknown 152990342 Common - sulfate adenylyltransferase NIS_0593 56 COG2046 MET3, ATP sulfurylase (sulfate adenylyltransferase) Inorganic ion transport and metabolism 152990442 Nonpathogen - hypothetical protein NIS_0693 2 None None None 152990237 Common - aspartate-semialdehyde dehydrogenase NIS_0488 235 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 152990710 Common - Ni-Fe hydrogenase, cytochrome b subunit NIS_0965 40 COG1969 HyaC, Ni,Fe-hydrogenase I cytochrome b subunit Energy production and conversion 152990087 Common dnaB replicative DNA helicase DnaB NIS_0338 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 152991241 Common - membrane bound endonuclease NIS_1499 41 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 152991423 Common - hypothetical protein NIS_1682 7 None None None 152991492 Common - hypothetical protein NIS_1752 27 COG2930 COG2930, Uncharacterized conserved protein Function unknown 152991566 Common - hypothetical protein NIS_1827 7 None None None 152990800 Common - lipoprotein thiredoxin NIS_1055 15 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 152990376 Common - flagellar hook capping protein FlgD NIS_0627 52 COG1843 FlgD, Flagellar hook capping protein Cell motility and secretion 152989960 Common - hypothetical protein NIS_0211 40 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 152990260 Common - hypothetical protein NIS_0511 6 None None None 152991106 Nonpathogen - nucleotidyltransferase NIS_1363 9 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 152990230 Nonpathogen - hypothetical protein NIS_0481 1 None None None 152991485 Common - amino acid transporter NIS_1745 189 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 152989826 Nonpathogen - hypothetical protein NIS_0074 2 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 152991000 Common - glycerol-3-phosphate cytidyltransferase NIS_1257 112 COG0615 TagD, Cytidylyltransferase Cell envelope biogenesis, outer membrane / Lipid metabolism 152991337 Common - hypothetical protein NIS_1596 24 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 152990656 Nonpathogen - hypothetical protein NIS_0910 2 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 152990178 Common - amidohydrolase family protein NIS_0429 133 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 152990913 Common hisG ATP phosphoribosyltransferase NIS_1169 210 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 152990535 Common - chemotaxis protein methyltransferase NIS_0788 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 152990619 Common - phosphoribosylformylglycinamidine synthase, large subunit NIS_0872 232 COG0047 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain Nucleotide transport and metabolism 152990840 Common - hypothetical protein NIS_1096 143 COG2081 COG2081, Predicted flavoproteins General function prediction only 152991030 Common - DNA polymerase IV, family X NIS_1287 94 COG1796 POL4, DNA polymerase IV (family X) DNA replication, recombination, and repair 152990719 Common - hydrogenase accessory protein HypB NIS_0974 133 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 152990803 Nonpathogen - hypothetical protein NIS_1058 2 None None None 152991361 Common - two-component sensor histidine kinase NIS_1620 183 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 152991313 Common - hypothetical protein NIS_1571 2 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 152990353 Common cheA chemotaxis sensor histidine kinase CheA NIS_0604 158 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 152991098 Common - sigma 54 modulation protein/ribosomal protein S30EA NIS_1355 33 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 152991152 Common - ribosomal protein L11 methyltransferase NIS_1410 174 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 152991024 Common - glutamyl-tRNA amidotransferase subunit A NIS_1281 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 152990399 Common pabA aminodeoxychorismate synthase subunit II NIS_0650 241 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 152990769 Common hemA glutamyl-tRNA reductase NIS_1024 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 152991559 Common - hypothetical protein NIS_1820 95 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152991224 Common - hypothetical protein NIS_1482 45 COG2121 COG2121, Uncharacterized protein conserved in bacteria Function unknown 152990042 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase NIS_0293 207 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 152989808 Common - D-isomer specific 2-hydroxyacid dehydrogenase, catalytic component NIS_0056 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 152991296 Common - aminotransferase, class I and II NIS_1554 239 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 152990216 Nonpathogen - hypothetical protein NIS_0467 1 None None None 152991161 Common - hypothetical protein NIS_1419 17 COG3945 COG3945, Uncharacterized conserved protein Function unknown 152990568 Common ubiX 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiX NIS_0821 151 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 152991217 Common - 4-diphosphocytidyl-2C-methyl-D-erythritol kinase NIS_1475 81 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 152990628 Common - hypothetical protein NIS_0881 214 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 152990425 Common - tRNA/rRNA cytosine-C5-methylase, NOL1/NOP2/Sun family NIS_0676 202 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 152990638 Common - hypothetical protein NIS_0891 50 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 152991181 Common - hypothetical protein NIS_1439 49 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 152991275 Common panC pantoate--beta-alanine ligase NIS_1533 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 152989766 Nonpathogen - hypothetical protein NIS_0013 11 None None None 152991401 Common - signal transduction response regulator NIS_1660 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152990296 Common - cytochrome c peroxidase NIS_0547 93 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 152990875 Common ribF riboflavin biosynthesis regulatory protein RibF NIS_1131 209 COG0196 RibF, FAD synthase Coenzyme metabolism 152990590 Common - 2-oxoglutarate ferredoxin oxidoreductase, beta subunit NIS_0843 108 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 152991575 Common - hypothetical protein NIS_1836 9 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 152990331 Common pstS phosphate ABC transporter, substrate-binding protein NIS_0582 102 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 152990278 Common - hypothetical protein NIS_0529 42 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 152990332 Nonpathogen - hypothetical protein NIS_0583 3 None None None 152991084 Common - aspartate oxidase NIS_1341 226 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 152991122 Common serS seryl-tRNA synthetase NIS_1379 243 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 152989977 Common rplV 50S ribosomal protein L22 NIS_0228 194 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 152991110 Nonpathogen - hypothetical protein NIS_1367 5 None None None 152991314 Nonpathogen - hypothetical protein NIS_1572 3 COG4795 PulJ, Type II secretory pathway, component PulJ Intracellular trafficking and secretion 152991116 Common - hypothetical protein NIS_1373 50 COG1993 COG1993, Uncharacterized conserved protein Function unknown 152989875 Common - ribosome-associated GTPase NIS_0125 163 COG1162 COG1162, Predicted GTPases General function prediction only 152990072 Common - Na+/H+:dicarboxylate/amino acid symporter NIS_0323 165 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 152990029 Common - phage repressor protein NIS_0280 33 COG2932 COG2932, Predicted transcriptional regulator Transcription 152989900 Common - hypothetical protein NIS_0150 159 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152990465 Common - Ni-Fe hydrogenase, membrane subunit HyfF NIS_0716 184 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 152991592 Common dgt deoxyguanosinetriphosphate triphosphohydrolase NIS_1853 160 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 152991281 Common - hypothetical protein NIS_1539 62 COG1683 COG1683, Uncharacterized conserved protein Function unknown 152990391 Common - flagellar hook-associated protein 2 FliD NIS_0642 87 COG1345 FliD, Flagellar capping protein Cell motility and secretion 152989997 Common rpsD 30S ribosomal protein S4 NIS_0248 245 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 152990863 Common - hypothetical protein NIS_1119 51 COG3663 Mug, G:T/U mismatch-specific DNA glycosylase DNA replication, recombination, and repair 152991117 Common crcB camphor resistance protein CrcB NIS_1374 54 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 152991450 Common deaD ATP-dependent RNA helicase, DEAD-box family NIS_1709 241 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 152989953 Common - hypothetical protein NIS_0204 97 COG1981 COG1981, Predicted membrane protein Function unknown 152991040 Common - carboxynorspermidine decarboxylase NIS_1297 62 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 152989907 Common recJ single-strand DNA-specific exonuclease NIS_0157 192 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 152990976 Common obg GTP-binding protein Obg NIS_1232 249 COG0536 Obg, Predicted GTPase General function prediction only 152991340 Common - hypothetical protein NIS_1599 76 COG4121 COG4121, Uncharacterized conserved protein Function unknown 152990944 Common gltD glutamate synthase (NADPH), small chain NIS_1200 229 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 152989810 Common - hypothetical protein NIS_0058 8 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 152990853 Common - hypothetical protein NIS_1109 66 COG1355 COG1355, Predicted dioxygenase General function prediction only 152991478 Common - hypothetical protein NIS_1737 31 COG2128 COG2128, Uncharacterized conserved protein Function unknown 152989801 Nonpathogen - hypothetical protein NIS_0049 8 None None None 152990397 Common - hypothetical protein NIS_0648 84 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 152990492 Common - transposase NIS_0744 156 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 152991068 Nonpathogen - hypothetical protein NIS_1325 1 None None None 152991443 Common - hypothetical protein NIS_1702 2 None None None 152991005 Common - adenine-specific DNA methyltransferase NIS_1262 100 COG0338 Dam, Site-specific DNA methylase DNA replication, recombination, and repair 152990192 Nonpathogen - hypothetical protein NIS_0443 1 None None None 152990815 Common - hypothetical protein NIS_1070 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 152989844 Nonpathogen - hypothetical protein NIS_0092 2 None None None 152991154 Common hisH amidotransferase HisH NIS_1412 215 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 152991321 Common - hypothetical protein NIS_1579 20 COG2863 COG2863, Cytochrome c553 Energy production and conversion 152990404 Common - hypothetical protein NIS_0655 91 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 152990000 Common - hypothetical protein NIS_0251 101 COG0694 COG0694, Thioredoxin-like proteins and domains Posttranslational modification, protein turnover, chaperones 152990408 Common pheS phenylalanyl-tRNA synthetase, alpha subunit NIS_0659 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 152991550 Nonpathogen - hypothetical protein NIS_1810 8 None None None 152991091 Common lon ATP-dependent Lon protease NIS_1348 228 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 152990386 Common - hypothetical protein NIS_0637 2 None None None 152989995 Common rpsM 30S ribosomal protein S13 NIS_0246 247 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 152990463 Common - Ni-Fe hydrogenase, small subunit HycG NIS_0714 192 COG3260 COG3260, Ni,Fe-hydrogenase III small subunit Energy production and conversion 152990541 Common metG methionyl-tRNA synthetase NIS_0794 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152990151 Nonpathogen - hypothetical protein NIS_0402 3 None None None 152990034 Common - hypothetical protein NIS_0285 5 None None None 152990189 Common - site-specific recombinase, phage integrase family NIS_0440 115 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 152990924 Common trpE anthranilate synthase component I NIS_1180 221 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 152990957 Common - hypothetical protein NIS_1213 26 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 152991533 Common - cytochrome c, class I NIS_1793 19 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 152989924 Common - potassium channel protein NIS_0175 109 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 152990617 Common plsC 1-acyl-sn-glycerol-3-phosphate acyltransferase NIS_0870 133 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 152991338 Common - hypothetical protein NIS_1597 74 COG2078 AMMECR1, Uncharacterized conserved protein Function unknown 152989965 Common aroC chorismate synthase NIS_0216 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 152991403 Common tpx thiol peroxidase NIS_1662 103 COG2077 Tpx, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 152990413 Common - D-3-phosphoglycerate dehydrogenase NIS_0664 230 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 152991548 Common napA periplasmic nitrate reductase, large subunit NIS_1808 182 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 152991051 Common - phosphoserine phosphatase NIS_1308 151 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 152989864 Common - ABC transporter, ATP-binding protein NIS_0112 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 152990024 Common - chemotaxis protein methyltransferase NIS_0275 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 152990751 Common - general secretory pathway protein D NIS_1006 140 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 152990032 Common - UDP-glucose/GDP-mannose dehydrogenase NIS_0283 207 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 152991140 Common - hypothetical protein NIS_1398 14 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 152990848 Common dfp DNA/pantothenate metabolism flavoprotein NIS_1104 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 152990158 Common - 4Fe-4S ferredoxin NIS_0409 159 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 152990135 Common - hypothetical protein NIS_0386 31 COG0795 COG0795, Predicted permeases General function prediction only 152990774 Common - S-adenosyl-methyltransferase MraW NIS_1029 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 152991412 Common - AcrA/AcrE family protein NIS_1671 153 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 152990305 Nonpathogen - hypothetical protein NIS_0556 2 None None None 152990182 Common - flagellar biosynthesis switch protein FlhG NIS_0433 232 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 152991311 Common - hypothetical protein NIS_1569 5 None None None 152991482 Common - hypothetical protein NIS_1742 13 None None None 152990228 Common - hypothetical protein NIS_0479 2 None None None 152991163 Common - hypothetical protein NIS_1421 22 None None None 152991557 Common - hypothetical protein NIS_1817 3 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 152990368 Common - hypothetical protein NIS_0619 4 None None None 152990504 Common - peptidase, M23/M37 family NIS_0757 7 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 152990452 Common - GTP-binding protein NIS_0703 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 152990966 Common atpA F0F1-type ATP synthase, alpha subunit NIS_1222 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 152991187 Common - hypothetical protein NIS_1445 115 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 152990911 Nonpathogen - hypothetical protein NIS_1167 1 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 152991236 Common - hypothetical protein NIS_1494 145 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 152990111 Common - hypothetical protein NIS_0362 14 None None None 152990163 Common nadA quinolinate synthase NIS_0414 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 152990673 Common - fructose-bisphosphate aldolase, class I NIS_0927 58 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 152990218 Common - hypothetical protein NIS_0469 3 None None None 152990417 Common - acriflavin resistance protein, AcrB/AcrD/AcrF family NIS_0668 123 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 152991250 Common kdtA 3-deoxy-D-manno-octulosonic-acid transferase NIS_1508 128 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 152991526 Common - 4Fe-4S ferredoxin NIS_1786 47 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 152990640 Common - hypothetical protein NIS_0893 29 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 152990666 Common gpmA phosphoglycerate mutase NIS_0920 137 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 152990908 Common rpsF 30S ribosomal protein S6 NIS_1164 206 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 152990205 Nonpathogen - hypothetical protein NIS_0456 1 None None None 152990552 Common - ferrous iron transport protein A NIS_0805 6 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 152990897 Common - hypothetical protein NIS_1153 8 COG2353 COG2353, Uncharacterized conserved protein Function unknown 152990204 Nonpathogen - hypothetical protein NIS_0455 2 None None None 152991328 Nonpathogen - hypothetical protein NIS_1586 3 None None None 152991139 Common - ABC transporter, ATP-binding protein NIS_1397 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 152990755 Common - general secretory pathway protein E NIS_1010 215 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 152989983 Common rplX 50S ribosomal protein L24 NIS_0234 124 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 152991259 Common - hypothetical protein NIS_1517 23 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 152991494 Common - two-component response regulator NIS_1754 209 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152991283 Common - aldehyde dehydrogenase NIS_1541 224 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 152991568 Common - hypothetical protein NIS_1829 33 COG3258 COG3258, Cytochrome c Energy production and conversion 152990581 Common - isocitrate dehydrogenase, NADP-dependent NIS_0834 65 COG2838 Icd, Monomeric isocitrate dehydrogenase Energy production and conversion 152991430 Nonpathogen - hypothetical protein NIS_1689 1 None None None 152991464 Common - efflux system, membrane fusion protein NIS_1723 145 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 152989780 Common - hypothetical protein NIS_0027 89 COG0701 COG0701, Predicted permeases General function prediction only 152990039 Common nuoC NADH-quinone oxidoreductase, chain C NIS_0290 168 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 152991363 Nonpathogen - hypothetical protein NIS_1622 1 None None None 152990156 Common - hypothetical protein NIS_0407 161 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 152991581 Common - polysaccharide deacetylase family protein NIS_1842 81 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 152991303 Nonpathogen - fimbrial protein NIS_1561 1 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 152990259 Common groES co-chaperonin GroES NIS_0510 215 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 152990231 Nonpathogen - hypothetical protein NIS_0482 6 None None None 152991145 Common - type I secretion system ATPase NIS_1403 249 COG4618 ArpD, ABC-type protease/lipase transport system, ATPase and permease components General function prediction only 152990672 Common lipB lipoate-protein ligase B NIS_0926 160 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 152991060 Common - hypothetical protein NIS_1317 68 COG0679 COG0679, Predicted permeases General function prediction only 152990005 Common - hypothetical protein NIS_0256 7 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 152990624 Common - hypothetical protein NIS_0877 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152989843 Common - hypothetical protein NIS_0091 27 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 152989935 Common - hypothetical protein NIS_0186 13 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 152990430 Nonpathogen - hypothetical protein NIS_0681 30 COG1913 COG1913, Predicted Zn-dependent proteases General function prediction only 152989793 Nonpathogen - hypothetical protein NIS_0040 1 None None None 152990265 Common pyrF orotidine 5`-phosphate decarboxylase NIS_0516 174 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 152991021 Common - O-acetylhomoserine sulfhydrylase NIS_1278 208 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 152991304 Common - general secretory pathway protein F NIS_1562 147 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 152991141 Nonpathogen - hypothetical protein NIS_1399 2 None None None 152991193 Common - hypothetical protein NIS_1451 6 COG3197 FixS, Uncharacterized protein, possibly involved in nitrogen fixation Inorganic ion transport and metabolism 152989880 Common purT phosphoribosylglycinamide formyltransferase 2 NIS_0130 230 COG0027 PurT, Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) Nucleotide transport and metabolism 152990322 Common - molybdopterin oxidoreductase NIS_0573 177 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 152991132 Nonpathogen - hypothetical protein NIS_1389 2 None None None 152990792 Common - hypothetical protein NIS_1047 16 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 152990727 Common - chorismate mutase NIS_0982 38 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 152990645 Common - two-component sensor histidine kinase NIS_0898 206 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152990531 Common - peptidoglycan glycosyltransferase NIS_0784 204 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 152990588 Common - 2-oxoglutarate ferredoxin oxidoreductase, delta subunit NIS_0841 36 COG1146 COG1146, Ferredoxin Energy production and conversion 152990825 Common - tRNA modifying enzyme NIS_1081 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 152990257 Common ugpQ glycerophosphoryl diester phosphodiesterase NIS_0508 163 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 152991513 Common - pyruvate kinase NIS_1773 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 152991506 Common - hypothetical protein NIS_1766 46 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 152991194 Common - heavy-metal transporting P-type ATPase NIS_1452 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 152991112 Common - GTP-binding protein, Era/ThdF family NIS_1369 232 COG1160 COG1160, Predicted GTPases General function prediction only 152990054 Common - signal transduction response regulator NIS_0305 177 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152990272 Common - cyclic nucleotide binding protein NIS_0523 73 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 152990334 Common pstA phosphate ABC transporter, permease NIS_0585 227 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 152990359 Common flgG flagellar basal-body rod protein FlgG NIS_0610 126 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 152991558 Common - 4Fe-4S ferredoxin NIS_1818 154 COG1140 NarY, Nitrate reductase beta subunit Energy production and conversion 152990606 Common gpsA glycerol-3-phosphate dehydrogenase (NAD(P)+) NIS_0859 211 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 152991270 Common alaS alanyl-tRNA synthetase NIS_1528 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152989929 Common - hypothetical protein NIS_0180 19 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 152990006 Common ispA geranyltranstransferase NIS_0257 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 152990596 Common trpD anthranilate phosphoribosyltransferase NIS_0849 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 152990319 Common - hypothetical protein NIS_0570 90 COG1184 GCD2, Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 152989937 Common - hypothetical protein NIS_0188 3 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 152991402 Common - UDP-N-acetylmuramate dehydrogenase NIS_1661 167 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 152991137 Common - glycosyl transferase NIS_1395 82 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152991125 Nonpathogen - hypothetical protein NIS_1382 1 None None None 152990865 Common dnaK chaperone protein DnaK NIS_1121 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 152991345 Common - pyruvate:ferredoxin oxidoreductase, delta subunit NIS_1604 65 COG1144 COG1144, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit Energy production and conversion 152989975 Common rplB 50S ribosomal protein L2 NIS_0226 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 152990942 Common accD acetyl-CoA carboxylase, carboxyl transferase subunit beta NIS_1198 220 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 152991594 Common - thymidylate synthase, flavin-dependent NIS_1855 59 COG1351 THY1, Predicted alternative thymidylate synthase Nucleotide transport and metabolism 152991016 Common - ThiF/MoeB/HesA family protein NIS_1273 42 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 152991109 Common - hypothetical protein NIS_1366 104 COG2962 RarD, Predicted permeases General function prediction only 152990393 Common - flagellar hook-associated protein 3 FliC NIS_0644 77 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 152991212 Common - hypothetical protein NIS_1470 14 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 152990921 Common - lysyl-tRNA synthetase NIS_1177 249 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 152989788 Nonpathogen - sulfur oxidation protein SoxZ NIS_0035 15 None None None 152991014 Common - hypothetical protein NIS_1271 8 COG5611 COG5611, Predicted nucleic-acid-binding protein, contains PIN domain General function prediction only 152991219 Common - signal transduction response regulator NIS_1477 181 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152991188 Common - lipopolysaccharide heptosyltransferase NIS_1446 78 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 152990974 Common - tRNA pseudouridine synthase D NIS_1230 86 COG0585 COG0585, Uncharacterized conserved protein Function unknown 152991102 Common - hypothetical protein NIS_1359 31 COG4636 Uma2, Uncharacterized protein conserved in cyanobacteria Function unknown 152990078 Common - carbonate dehydratase NIS_0329 151 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 152991534 Common - cytochrome cd1 nitrite reductase NIS_1794 20 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 152989834 Common - hypothetical protein NIS_0082 17 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152990779 Common - ABC transporter, ATP-binding protein NIS_1034 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 152991173 Common - nucleotidyltransferase NIS_1431 123 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 152991332 Common - sulfonate/nitrate ABC transporter, substrate-binding protein NIS_1591 35 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 152991584 Common - hypothetical protein NIS_1845 9 COG1714 COG1714, Predicted membrane protein/domain Function unknown 152990261 Common - two-component response regulator NIS_0512 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152990859 Nonpathogen - hypothetical protein NIS_1115 4 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 152991529 Common - nitrous-oxide reductase NosZ NIS_1789 40 COG4263 NosZ, Nitrous oxide reductase Energy production and conversion 152989978 Common rpsC 30S ribosomal protein S3 NIS_0229 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 152990351 Common - chemotactic response regulator CheV NIS_0602 188 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 152990851 Common - hypothetical protein NIS_1107 16 COG0795 COG0795, Predicted permeases General function prediction only 152991108 Common - hypothetical protein NIS_1365 28 COG4636 Uma2, Uncharacterized protein conserved in cyanobacteria Function unknown 152989958 Common - signal transduction response regulator NIS_0209 180 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152990284 Common - long-chain fatty-acid-CoA ligase NIS_0535 225 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152990318 Common - hypothetical protein NIS_0569 23 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 152990713 Common - hypothetical protein NIS_0968 5 None None None 152990877 Common ligA DNA ligase, NAD-dependent NIS_1133 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 152991370 Common - invasion antigen B NIS_1629 6 None None None 152990639 Common - hypothetical protein NIS_0892 37 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 152991265 Common - 8-amino-7-oxononanoate synthase NIS_1523 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 152990576 Common - hypothetical protein NIS_0829 7 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 152991119 Nonpathogen - hypothetical protein NIS_1376 10 None None None 152991560 Nonpathogen - hypothetical protein NIS_1821 9 None None None 152989951 Common - hypothetical protein NIS_0202 18 COG3787 COG3787, Uncharacterized protein conserved in bacteria Function unknown 152990295 Common - hypothetical protein NIS_0546 7 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 152990618 Common - hypothetical protein NIS_0871 7 None None None 152990705 Common - transcriptional regulator, TetR family NIS_0960 101 COG1309 AcrR, Transcriptional regulator Transcription 152991567 Common - sulfur oxidation protein SoxB NIS_1828 132 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 152991375 Common - hypothetical protein NIS_1634 77 COG2902 COG2902, NAD-specific glutamate dehydrogenase Amino acid transport and metabolism 152991240 Common - hypothetical protein NIS_1498 4 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 152991247 Common ffh signal recognition particle protein NIS_1505 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 152989877 Common - hypothetical protein NIS_0127 6 COG1409 Icc, Predicted phosphohydrolases General function prediction only 152989833 Common - hypothetical protein NIS_0081 35 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152990423 Common - glycosyl transferase NIS_0674 222 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152989764 Common - transcriptional regulator NIS_0011 49 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 152991075 Common - site-specific recombinase, phage integrase family NIS_1332 114 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 152990094 Common - hypothetical protein NIS_0345 76 None None None 152991120 Common - glutamine amidotransferase, class I NIS_1377 146 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 152991353 Common - hypothetical protein NIS_1612 7 COG1512 COG1512, Beta-propeller domains of methanol dehydrogenase type General function prediction only 152990173 Common - riboflavin biosynthesis protein RibG NIS_0424 199 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 152990757 Common - ATP-dependent DNA helicase, UvrD/REP family NIS_1012 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 152989819 Common - hypothetical protein NIS_0067 19 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 152990529 Common - acetyltransferase, GNAT family NIS_0782 94 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 152990022 Common cheB protein-glutamate methylesterase CheB NIS_0273 221 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 152991425 Common - hypothetical protein NIS_1684 2 None None None 152990613 Common - oligopeptide ABC transporter, ATP-binding protein NIS_0866 249 COG1124 DppF, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 152989991 Common secY preprotein translocase subunit Y NIS_0242 244 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 152989857 Common rpsT 30S ribosomal protein S20 NIS_0105 195 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 152989894 Common - ferredoxin-like protein NIS_0144 81 COG0348 NapH, Polyferredoxin Energy production and conversion 152990763 Common sufD Fe-S cluster assembly protein SufD NIS_1018 166 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 152990180 Common - X-Pro dipeptidase NIS_0431 247 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 152990344 Common - bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase NIS_0595 192 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 152991207 Common secF preprotein translocase subunit F NIS_1465 217 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 152989820 Nonpathogen - hypothetical protein NIS_0068 2 None None None 152991388 Common - hypothetical protein NIS_1647 165 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152990514 Nonpathogen - hypothetical protein NIS_0767 3 COG1550 COG1550, Uncharacterized protein conserved in bacteria Function unknown 152991201 Common - hypothetical protein NIS_1459 81 COG1692 COG1692, Uncharacterized protein conserved in bacteria Function unknown 152991471 Common - DedA family protein NIS_1730 109 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 152991476 Common - hypothetical protein NIS_1735 7 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 152989943 Common - hypothetical protein NIS_0194 105 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 152990243 Nonpathogen - hypothetical protein NIS_0494 1 None None None 152990660 Common - two-component response regulator NIS_0914 221 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152990520 Common recN DNA repair protein RecN NIS_0773 200 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 152991396 Nonpathogen - hypothetical protein NIS_1655 2 None None None 152990258 Common groEL co-chaperonin GroEL NIS_0509 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 152990540 Common - hypothetical protein NIS_0793 7 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 152990564 Common speA arginine decarboxylase NIS_0817 87 COG1166 SpeA, Arginine decarboxylase (spermidine biosynthesis) Amino acid transport and metabolism 152990989 Common - transposase NIS_1246 22 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 152990214 Common - phage terminase, large subunit NIS_0465 28 COG1783 XtmB, Phage terminase large subunit General function prediction only 152989917 Common - hypothetical protein NIS_0168 117 COG2855 COG2855, Predicted membrane protein Function unknown 152990234 Common - MoaA/NifB/PqqE family protein NIS_0485 56 COG0731 COG0731, Fe-S oxidoreductases Energy production and conversion 152991355 Common - hypothetical protein NIS_1614 4 None None None 152990728 Common - hypothetical protein NIS_0983 59 COG1360 MotB, Flagellar motor protein Cell motility and secretion 152991015 Nonpathogen - hypothetical protein NIS_1272 2 None None None 152990187 Common - hypothetical protein NIS_0438 5 None None None 152990685 Common galT galactose-1-phosphate uridylyltransferase NIS_0939 76 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 152991516 Common - transcriptional regulator, AsnC/Lrp family NIS_1776 51 COG1522 Lrp, Transcriptional regulators Transcription 152990457 Common rpiB ribose 5-phosphate isomerase B NIS_0708 129 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 152991405 Common - hypothetical protein NIS_1664 45 COG3545 COG3545, Predicted esterase of the alpha/beta hydrolase fold General function prediction only 152991497 Common - nitrate/sulfonate/bicarbonate ABC transporter, substrate-binding protein NIS_1757 70 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 152990622 Common - protease NIS_0875 181 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 152990488 Common - hypothetical protein NIS_0739 63 COG3108 COG3108, Uncharacterized protein conserved in bacteria Function unknown 152991326 Common - ubiquinol cytochrome c oxidoreductase, cytochrome b subunit NIS_1584 149 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 152990365 Common - flagellar biosynthesis protein FlhF NIS_0616 247 COG1419 FlhF, Flagellar GTP-binding protein Cell motility and secretion 152989989 Common rpsE 30S ribosomal protein S5 NIS_0240 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 152990153 Common - von Willebrand factor type A domain protein NIS_0404 73 COG4372 COG4372, Uncharacterized protein conserved in bacteria with the myosin-like domain Function unknown 152990822 Common fur ferric uptake regulator NIS_1078 207 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 152990562 Common - aspartate aminotransferase NIS_0815 237 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 152990894 Common - peroxide stress regulator NIS_1150 188 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 152990137 Common - HAD-superfamily hydrolase NIS_0388 91 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 152991143 Common - type I secretion system outer membrane protein NIS_1401 81 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 152991086 Common uvrC excinuclease ABC, C subunit NIS_1343 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 152991147 Common - glycosyl transferase NIS_1405 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 152991302 Nonpathogen - hypothetical protein NIS_1560 1 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 152989798 Common pcm L-isoaspartyl protein carboxyl methyltransferase NIS_0045 154 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 152991569 Nonpathogen - hypothetical protein NIS_1830 23 None None None 152991191 Common - ADP-L-glycero-D-mannoheptose-6-epimerase NIS_1449 231 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152991504 Common upp uracil phosphoribosyltransferase NIS_1764 163 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 152990108 Common ribA GTP cyclohydrolase II NIS_0359 176 COG0807 RibA, GTP cyclohydrolase II Coenzyme metabolism 152989773 Common - molybdenum ABC transporter, substrate-binding protein NIS_0020 67 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 152989859 Common lspA lipoprotein signal peptidase II NIS_0107 135 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 152990670 Common - hypothetical protein NIS_0924 192 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 152990823 Common - hypothetical protein NIS_1079 6 None None None 152990736 Common - hypothetical protein NIS_0991 22 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 152990918 Common - glutamyl-tRNA amidotransferase subunit C NIS_1174 102 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 152990439 Common - succinate dehydrogenase/fumarate reductase, flavoprotein subunit NIS_0690 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 152991433 Nonpathogen - hypothetical protein NIS_1692 1 None None None 152990435 Common - hypothetical protein NIS_0686 6 COG5659 COG5659, FOG: Transposase DNA replication, recombination, and repair 152990307 Nonpathogen - hypothetical protein NIS_0558 1 None None None 152991008 Common - hypothetical protein NIS_1265 11 None None None 152990648 Common - heavy metal efflux pump, CzcA family NIS_0902 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 152991523 Common - ferredoxin-type protein, NapH/MauN family NIS_1783 54 COG0348 NapH, Polyferredoxin Energy production and conversion 152990209 Nonpathogen - hypothetical protein NIS_0460 1 None None None 152990799 Common - hypothetical protein NIS_1054 46 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 152989920 Common purN phosphoribosylglycinamide formyltransferase NIS_0171 220 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 152990010 Common rpmG 50S ribosomal protein L33 NIS_0261 76 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 152991531 Common - heme d1 biosynthesis protein NirF NIS_1791 18 None None None 152991318 Common - nucleotidyltransferase NIS_1576 13 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 152990503 Common ftsX cell division protein FtsX NIS_0756 7 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 152991578 Common - hypothetical protein NIS_1839 2 None None None 152990817 Common pncB nicotinate phosphoribosyltransferase NIS_1072 152 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 152990202 Nonpathogen - hypothetical protein NIS_0453 2 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 152989885 Common - hypothetical protein NIS_0135 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152990992 Common - undecaprenyl-phosphate galactose phosphotransferase NIS_1249 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 152991257 Nonpathogen - hypothetical protein NIS_1515 1 None None None 152990018 Common rpoC DNA-directed RNA polymerase, beta' subunit NIS_0269 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 152991438 Common - hypothetical protein NIS_1697 17 COG1462 CsgG, Uncharacterized protein involved in formation of curli polymers Cell envelope biogenesis, outer membrane 152990068 Common rpmB 50S ribosomal protein L28 NIS_0319 177 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 152990968 Nonpathogen - F0F1-type ATP synthase, B subunit NIS_1224 1 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 152991473 Common - hypothetical protein NIS_1732 164 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152990381 Common fliP flagellar transport protein FliP NIS_0632 128 COG1338 FliP, Flagellar biosynthesis pathway, component FliP Cell motility and secretion / Intracellular trafficking and secretion 152990104 Common - alanine racemase NIS_0355 199 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 152990366 Common - flagellar biosynthesis switch protein FlhG NIS_0617 171 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 152990148 Common fabH 3-oxoacyl-[acyl-carrier-protein] synthase III NIS_0399 230 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 152990658 Common - heavy metal efflux pump, CzcA family NIS_0912 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 152991267 Common - septum formation protein NIS_1525 177 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 152990544 Common - molybdopterin-guanine dinucleotide biosynthesis protein B NIS_0797 80 COG1763 MobB, Molybdopterin-guanine dinucleotide biosynthesis protein Coenzyme metabolism 152991205 Common - hypothetical protein NIS_1463 7 None None None 152991165 Common - biopolymer transport protein, ExbD/TolR family NIS_1423 34 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 152989802 Common - oxidoreductase NIS_0050 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152990940 Common - hypothetical protein NIS_1196 162 COG1576 COG1576, Uncharacterized conserved protein Function unknown 152991546 Common napH periplasmic nitrate reductase, iron-sulfur cluster-binding protein NapH NIS_1806 83 COG0348 NapH, Polyferredoxin Energy production and conversion 152990905 Common ilvC ketol-acid reductoisomerase NIS_1161 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 152989980 Nonpathogen rpmC 50S ribosomal protein L29 NIS_0231 1 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 152990120 Common - hypothetical protein NIS_0371 126 COG0628 PerM, Predicted permease General function prediction only 152990324 Common - hypothetical protein NIS_0575 27 COG2361 COG2361, Uncharacterized conserved protein Function unknown 152990226 Common - hypothetical protein NIS_0477 6 COG5448 COG5448, Uncharacterized conserved protein Function unknown 152989846 Common feoA ferrous iron transport protein A NIS_0094 47 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 152990040 Common nuoD NADH-quinone oxidoreductase, chain D NIS_0291 192 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 152989908 Common - hypothetical protein NIS_0158 81 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 152990085 Common priA primosomal replication factor Y NIS_0336 212 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 152990846 Common - multidrug ABC transporter, ATP-binding protein and permease NIS_1102 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 152990887 Common - hypothetical protein NIS_1143 3 None None None 152990388 Nonpathogen - hypothetical protein NIS_0639 3 COG5581 COG5581, Predicted glycosyltransferase Cell envelope biogenesis, outer membrane 152990679 Common - pyruvate/2-oxoglutarate dehydrogenase complex, E1 component, beta subunit NIS_0933 213 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 152989862 Common rpmI 50S ribosomal protein L35 NIS_0110 25 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 152991413 Common - antimicrobial peptide ABC transporter, ATP-binding protein NIS_1672 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 152990194 Nonpathogen - hypothetical protein NIS_0445 1 None None None 152990586 Common sucD succinyl-CoA synthase, alpha subunit NIS_0839 216 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 152991130 Nonpathogen - hypothetical protein NIS_1387 1 None None None 152991410 Common leuC 3-isopropylmalate dehydratase, large subunit NIS_1669 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 152990632 Nonpathogen - hypothetical protein NIS_0885 3 None None None 152990402 Common - ATP citrate synthase, subunit 2 NIS_0653 205 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 152989922 Common - Na+:H+ antiporter, NapA NIS_0173 24 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 152990642 Common - phosphoribosylformylglycinamidine synthase II NIS_0895 234 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 152990740 Nonpathogen - hypothetical protein NIS_0995 1 None None None 152990804 Common - ABC transporter, permease NIS_1059 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 152990961 Common - biopolymer transport protein, ExbD/TolR family NIS_1217 7 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 152990950 Nonpathogen - hypothetical protein NIS_1206 1 None None None 152990932 Common polA DNA polymerase I NIS_1188 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 152990554 Common - hypothetical protein NIS_0807 138 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 152990454 Common - hypothetical protein NIS_0705 140 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 152989996 Common rpsK 30S ribosomal protein S11 NIS_0247 247 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 152991018 Common - exodeoxyribonuclease VII, small subunit NIS_1275 8 None None None 152990486 Nonpathogen - hypothetical protein NIS_0737 1 None None None 152991486 Common - hypothetical protein NIS_1746 127 COG2326 COG2326, Uncharacterized conserved protein Function unknown 152990172 Common - hypothetical protein NIS_0423 150 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 152990338 Nonpathogen - hypothetical protein NIS_0589 3 None None None 152990833 Nonpathogen - hypothetical protein NIS_1089 1 None None None 152990466 Common - Ni-Fe hydrogenase, membrane subunit HyfE NIS_0717 24 COG4237 HyfE, Hydrogenase 4 membrane component (E) Energy production and conversion 152990179 Common aroQ 3-dehydroquinate dehydratase II NIS_0430 170 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 152991012 Nonpathogen - hypothetical protein NIS_1269 4 None None None 152990045 Common nuoH NADH-quinone oxidoreductase, chain H NIS_0296 190 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 152990831 Common pdxA 4-hydroxythreonine-4-phosphate dehydrogenase NIS_1087 159 COG1995 PdxA, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 152991562 Common - ATP-binding protein NIS_1823 229 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 152990694 Common - hypothetical protein NIS_0949 113 COG1801 COG1801, Uncharacterized conserved protein Function unknown 152991556 Nonpathogen - hypothetical protein NIS_1816 1 None None None 152989968 Nonpathogen - prevent-host-death protein NIS_0219 1 COG4118 Phd, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 152991223 Nonpathogen - hypothetical protein NIS_1481 1 None None None 152990246 Common - hypothetical protein NIS_0497 31 COG4413 Utp, Urea transporter Amino acid transport and metabolism 152990761 Common sufB Fe-S cluster assembly protein SufB NIS_1016 186 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 152990715 Common - hypothetical protein NIS_0970 52 COG3022 COG3022, Uncharacterized protein conserved in bacteria Function unknown 152991028 Nonpathogen - hypothetical protein NIS_1285 1 None None None 152989956 Common - hypothetical protein NIS_0207 58 COG3228 COG3228, Uncharacterized protein conserved in bacteria Function unknown 152990141 Common - peroxiredoxin, AhpC/Tsa family NIS_0392 222 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 152990879 Common - cytochrome c peroxidase NIS_1135 91 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 152991081 Common - uroporphyrinogen-III synthase NIS_1338 22 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 152991279 Common rpsB 30S ribosomal protein S2 NIS_1537 230 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 152990538 Common - C4-dicarboxylate transporter, substrate-binding protein NIS_0791 108 COG4663 FcbT1, TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 152990662 Common - hypothetical protein NIS_0916 166 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152989814 Common - hypothetical protein NIS_0062 165 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 152990421 Common thiJ 4-methyl-5(beta-hydroxyethyl)-thiazole monophosphate synthesis protein NIS_0672 166 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 152989993 Common infA translation initiation factor IF-1 NIS_0244 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 152991048 Common - methyltransferase NIS_1305 145 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 152990765 Common hemC porphobilinogen deaminase NIS_1020 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 152991377 Common - molybdenum cofactor biosynthesis protein D NIS_1636 7 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 152990513 Common ppa inorganic pyrophosphatase NIS_0766 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 152991299 Common - RNA methyltransferase, TrmH family NIS_1557 214 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 152990860 Common dsbD thiol:disulfide interchange protein DsbD NIS_1116 152 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 152990312 Common - hypothetical protein NIS_0563 9 COG3608 COG3608, Predicted deacylase General function prediction only 152990703 Nonpathogen - hypothetical protein NIS_0958 3 None None None 152990898 Common - ABC transporter NIS_1154 185 COG0661 AarF, Predicted unusual protein kinase General function prediction only 152990293 Common - cell shape-determining protein MreC NIS_0544 11 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 152990633 Common metE 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase NIS_0886 142 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 152990116 Common - anaerobic glycerol-3-phosphate dehydrogenase subunit C NIS_0367 177 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 152991245 Common - hypothetical protein NIS_1503 7 COG1837 COG1837, Predicted RNA-binding protein (contains KH domain) General function prediction only 152990698 Common - hypothetical protein NIS_0953 15 COG2262 HflX, GTPases General function prediction only 152990027 Common - RNA-binding protein RNP-1 NIS_0278 66 COG0724 COG0724, RNA-binding proteins (RRM domain) General function prediction only 152990274 Common - hypothetical protein NIS_0525 40 COG3162 COG3162, Predicted membrane protein Function unknown 152990139 Common hisC histidinol-phosphate aminotransferase NIS_0390 231 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 152991293 Common - hypothetical protein NIS_1551 61 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 152991458 Common - potassium uptake protein NIS_1717 105 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 152991351 Common rplM 50S ribosomal protein L13 NIS_1610 229 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 152991095 Common - hypothetical protein NIS_1352 4 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 152990604 Common - potassium channel protein NIS_0857 162 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 152990667 Common - glyceraldehyde 3-phosphate dehydrogenase NIS_0921 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 152990780 Common - hypothetical protein NIS_1035 6 None None None 152990594 Common - methylated-DNA-[protein]-cysteine S-methyltransferase NIS_0847 217 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 152990357 Common - flagellar motor switch protein FliN NIS_0608 122 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 152991272 Common ftsW cell division protein FtsW NIS_1530 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 152991061 Common surE stationary-phase survival protein NIS_1318 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 152991393 Common - hypothetical protein NIS_1652 34 COG0622 COG0622, Predicted phosphoesterase General function prediction only 152990871 Common - hypothetical protein NIS_1127 8 COG2404 COG2404, Predicted phosphohydrolase (DHH superfamily) General function prediction only 152989762 Common - amino acid transporter NIS_0009 176 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 152991175 Common - hypothetical protein NIS_1433 139 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 152991104 Common ribE riboflavin synthase, beta chain NIS_1361 230 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 152989781 Common - redox-active disulfide protein 2 NIS_0028 67 None None None 152991596 Common ruvC crossover junction endodeoxyribonuclease RuvC NIS_1857 195 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 152990461 Common - hypothetical protein NIS_0712 7 None None None 152991214 Common - transcriptional regulator, LysR family NIS_1472 189 COG0583 LysR, Transcriptional regulator Transcription 152991050 Common - hypothetical protein NIS_1307 128 COG1881 COG1881, Phospholipid-binding protein General function prediction only 152989896 Common - sulfide-quinone reductase NIS_0146 98 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 152990395 Nonpathogen - hypothetical protein NIS_0646 1 None None None 152990857 Common - hypothetical protein NIS_1113 23 COG0392 COG0392, Predicted integral membrane protein Function unknown 152990949 Common - hypothetical protein NIS_1205 177 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152991088 Nonpathogen - hypothetical protein NIS_1345 3 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 152989930 Common - glucosaminyltransferase NIS_0181 222 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152991384 Common - tetrahydrodipicolinate N-succinyltransferase NIS_1643 156 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 152990787 Common argB acetylglutamate kinase NIS_1042 220 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 152989903 Common - hypothetical protein NIS_0153 5 COG2005 ModE, N-terminal domain of molybdenum-binding protein General function prediction only 152989973 Common rplD 50S ribosomal protein L4 NIS_0224 215 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 152991343 Common - pyruvate:ferredoxin oxidoreductase, beta subunit NIS_1602 123 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 152990076 Common - transferase, hexapeptide repeat family NIS_0327 211 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 152989945 Common - signal transduction response regulator NIS_0196 180 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152990239 Common - transcriptional regulator, Fis family NIS_0490 5 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 152990518 Common aspS aspartyl-tRNA synthetase NIS_0771 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152990038 Common nuoB NADH-quinone oxidoreductase, chain B NIS_0289 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 152990256 Common - transcriptional regulator NIS_0507 18 COG3054 COG3054, Predicted transcriptional regulator General function prediction only 152990525 Common - phosphatase, YrbI family NIS_0778 113 COG1778 COG1778, Low specificity phosphatase (HAD superfamily) General function prediction only 152991381 Common - malate oxidoreductase NIS_1640 194 COG0281 SfcA, Malic enzyme Energy production and conversion 152990542 Common - hypothetical protein NIS_0795 5 None None None 152990063 Common acpP acyl carrier protein ACP NIS_0314 210 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152989771 Common - sulfate ABC transporter, ATP-binding protein NIS_0018 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 152990986 Common - DNA/RNA helicase NIS_1242 106 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 152990522 Common - membrane-bound lytic murein transglycosylase D NIS_0775 116 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 152990459 Common lepB signal peptidase I NIS_0710 178 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 152989915 Common clpP ATP-dependent Clp protease, proteolytic subunit NIS_0165 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 152990566 Common tmk thymidylate kinase NIS_0819 221 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 152989899 Common - cytochrome bd oxidase subunit II NIS_0149 74 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 152991518 Nonpathogen - hypothetical protein NIS_1778 3 None None None 152990052 Common miaA tRNA isopentenyltransferase NIS_0303 213 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 152991200 Common - endonuclease III NIS_1458 99 COG2231 COG2231, Uncharacterized protein related to Endonuclease III DNA replication, recombination, and repair 152991186 Common - hypothetical protein NIS_1444 13 COG3660 COG3660, Predicted nucleoside-diphosphate-sugar epimerase Cell envelope biogenesis, outer membrane 152990471 Common - hypothetical protein NIS_0722 7 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152990186 Common - transformation system protein NIS_0437 12 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 152990498 Common - cell shape-determining protein RodA NIS_0751 205 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 152991073 Common - plasmid stabilization system NIS_1330 7 COG3041 COG3041, Uncharacterized protein conserved in bacteria Function unknown 152989779 Common arsB arsenic efflux pump protein NIS_0026 114 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 152989822 Common dtd D-tyrosyl-tRNA deacylase NIS_0070 139 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 152990190 Nonpathogen - hypothetical protein NIS_0441 1 None None None 152989939 Common - alginate biosynthesis protein Alg8 NIS_0190 5 None None None 152990971 Common - chromosome partitioning protein, ATPase ParA NIS_1227 236 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 152990382 Common fliQ flagellar biosynthetic protein FliQ NIS_0633 128 COG1987 FliQ, Flagellar biosynthesis pathway, component FliQ Cell motility and secretion / Intracellular trafficking and secretion 152990375 Common fliI flagellar-specific ATP synthase FliI NIS_0626 247 COG1157 FliI, Flagellar biosynthesis/type III secretory pathway ATPase Cell motility and secretion / Intracellular trafficking and secretion 152990978 Common rplU 50S ribosomal protein L21 NIS_1234 182 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 152990286 Common - peptidyl-prolyl cis-trans isomerase NIS_0537 196 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 152990263 Common - hypothetical protein NIS_0514 104 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 152990092 Common - peptidase, M23/M37 family NIS_0343 191 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 152990347 Common - hypothetical protein NIS_0598 5 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 152990446 Common pgsA CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase NIS_0697 207 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 152990934 Common - hypothetical protein NIS_1190 23 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 152990468 Common - Ni-Fe hydrogenase, membrane subunit HycC/HyfB NIS_0719 208 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 152991427 Nonpathogen - hypothetical protein NIS_1686 1 None None None 152990301 Common btuR cob(I)alamin adenosyltransferase NIS_0552 142 COG2109 BtuR, ATP:corrinoid adenosyltransferase Coenzyme metabolism 152989836 Nonpathogen - hypothetical protein NIS_0084 1 None None None 152990433 Common - signal transduction response regulator NIS_0684 176 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152990437 Common - succinate dehydrogenase/fumarate reductase, subunit C NIS_0688 49 COG2048 HdrB, Heterodisulfide reductase, subunit B Energy production and conversion 152990881 Common - dihydropteroate synthase NIS_1137 217 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 152990916 Common - hypothetical protein NIS_1172 7 None None None 152990584 Common - fumarate/tartrate hydratase, beta subunit NIS_0837 147 COG1838 FumA, Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain Energy production and conversion 152990556 Common - phosphatase, Ppx/GppA family NIS_0809 180 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 152991255 Common - hypothetical protein NIS_1513 40 COG1578 COG1578, Uncharacterized conserved protein Function unknown 152990790 Common - hypothetical protein NIS_1045 47 COG2833 COG2833, Uncharacterized protein conserved in bacteria Function unknown 152989887 Common - hypothetical protein NIS_0137 96 COG1671 COG1671, Uncharacterized protein conserved in bacteria Function unknown 152990127 Common - dethiobiotin synthetase NIS_0378 152 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 152991468 Common - multidrug ABC transporter, permease NIS_1727 130 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 152990208 Nonpathogen - hypothetical protein NIS_0459 1 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 152990384 Common flhB flagellar biosynthetic protein FlhB NIS_0635 130 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 152991039 Common - hypothetical protein NIS_1296 25 None None None 152990759 Common - sulfate transporter NIS_1014 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 152991124 Common - ABC transporter, permease NIS_1381 148 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 152990963 Common atpC F0F1-type ATP synthase, epsilon subunit NIS_1219 161 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 152990036 Common - ATPase, AAA family NIS_0287 238 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 152991261 Common glnA glutamine synthase NIS_1519 226 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 152991053 Common - hypothetical protein NIS_1310 5 None None None 152990484 Common - acetoin utilization protein NIS_0735 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 152990363 Nonpathogen - hypothetical protein NIS_0614 1 COG3951 COG3951, Rod binding protein Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 152989879 Common - hypothetical protein NIS_0129 130 COG0432 COG0432, Uncharacterized conserved protein Function unknown 152991309 Nonpathogen - hypothetical protein NIS_1567 1 None None None 152991564 Common - hypothetical protein NIS_1825 29 COG1416 COG1416, Uncharacterized conserved protein Function unknown 152991490 Common - [pyruvate formate-lyase]-activating enzyme NIS_1750 98 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 152990738 Common kdsB 3-deoxy-D-manno-octulosonate cytidylyltransferase NIS_0993 145 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 152990747 Common era GTP-binding protein Era NIS_1002 223 COG1159 Era, GTPase General function prediction only 152990892 Common xthA exodeoxyribonuclease III NIS_1148 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 152989927 Nonpathogen - hypothetical protein NIS_0178 1 None None None 152990722 Common - hydrogenase expression/formation protein HypE NIS_0977 119 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 152991455 Common - two-component response regulator NIS_1714 219 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152990867 Common - heat-inducible transcription repressor HrcA NIS_1123 119 COG1420 HrcA, Transcriptional regulator of heat shock gene Transcription 152990828 Common - hypothetical protein NIS_1084 10 COG3400 COG3400, Uncharacterized protein conserved in bacteria Function unknown 152991324 Common moaA molybdenum cofactor biosynthesis protein A NIS_1582 206 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 152990155 Common - prephenate dehydrogenase NIS_0406 155 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 152990973 Common fmt methionyl-tRNA formyltransferase NIS_1229 224 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 152991368 Common - aminotransferase NIS_1627 156 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 152990731 Nonpathogen - hypothetical protein NIS_0986 1 None None None 152991300 Common - hypothetical protein NIS_1558 210 COG0313 COG0313, Predicted methyltransferases General function prediction only 152990654 Common - transcriptional regulator, AsrR family NIS_0908 116 COG0640 ArsR, Predicted transcriptional regulators Transcription 152990743 Common argG argininosuccinate synthase NIS_0998 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 152990620 Common - phosphoribosylformylglycinamidine synthase, small subunit NIS_0873 118 COG1828 PurS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component Nucleotide transport and metabolism 152991317 Common - hypothetical protein NIS_1575 19 COG2445 COG2445, Uncharacterized conserved protein Function unknown 152991198 Common - glutamate racemase NIS_1456 186 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 152991502 Nonpathogen - hypothetical protein NIS_1762 1 None None None 152990601 Common - thiamine-phosphate pyrophosphorylase NIS_0854 41 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 152991500 Nonpathogen - hypothetical protein NIS_1760 5 COG1318 COG1318, Predicted transcriptional regulators Transcription 152991586 Common - methyl-accepting chemotaxis protein NIS_1847 164 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152990629 Common - hypothetical protein NIS_0882 9 COG1847 Jag, Predicted RNA-binding protein General function prediction only 152990164 Common nadC nicotinate-nucleotide pyrophosphorylase (carboxylating) NIS_0415 205 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 152990456 Common apt adenine phosphoribosyltransferase NIS_0707 178 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 152991499 Common - reverse gyrase Rgy NIS_1759 247 COG1110 COG1110, Reverse gyrase DNA replication, recombination, and repair 152990806 Common thiS thiamine biosynthesis protein ThiS NIS_1061 34 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 152991034 Common - hypothetical protein NIS_1291 5 None None None 152990309 Common - hypothetical protein NIS_0560 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 152990501 Common - tRNA (guanine-N(7)-)-methyltransferase NIS_0754 174 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 152990235 Common hemE uroporphyrinogen decarboxylase NIS_0486 179 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 152990004 Common panD aspartate decarboxylase NIS_0255 130 COG0853 PanD, Aspartate 1-decarboxylase Coenzyme metabolism 152989805 Common nrdA ribonucleoside-diphosphate reductase, alpha subunit NIS_0053 219 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 152991233 Common pgk phosphoglycerate kinase NIS_1491 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 152991407 Common ispC 1-deoxy-D-xylulose 5-phosphate reductoisomerase NIS_1666 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 152991221 Common - tRNA-lysidine synthase NIS_1479 207 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 152990952 Common - hypothetical protein NIS_1208 164 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 152990797 Common - cation efflux protein NIS_1052 208 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 152990959 Common - Tol biopolymer transport system component TolB NIS_1215 96 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 152990327 Common - ferredoxin-like protein NIS_0578 45 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 152990688 Nonpathogen - hypothetical protein NIS_0943 2 None None None 152989987 Common rplF 50S ribosomal protein L6 NIS_0238 244 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 152990734 Common - indole-3-glycerol phosphate synthase NIS_0989 219 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 152991554 Common - ferredoxin-like protein NIS_1814 32 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 152990820 Common - two-component sensor histidine kinase NIS_1076 219 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 152989940 Common - GDP-mannose 6-dehydrogenase NIS_0191 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 152990066 Common - hypothetical protein NIS_0317 4 COG2841 COG2841, Uncharacterized protein conserved in bacteria Function unknown 152990400 Common - hypothetical protein NIS_0651 8 None None None 152990219 Nonpathogen - hypothetical protein NIS_0470 1 None None None 152990143 Common - 4Fe-4S ferredoxin NIS_0394 115 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 152989868 Common - two-component response regulator NIS_0118 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152990598 Common - ABC transporter, ATP-binding protein NIS_0851 249 COG1137 YhbG, ABC-type (unclassified) transport system, ATPase component General function prediction only 152990696 Common - TonB-dependent receptor NIS_0951 103 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 152990412 Common rpsA 30S ribosomal protein S1 NIS_0663 220 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 152990248 Common - hypothetical protein NIS_0499 38 COG3919 COG3919, Predicted ATP-grasp enzyme General function prediction only 152989850 Common - hypothetical protein NIS_0098 68 COG1434 COG1434, Uncharacterized conserved protein Function unknown 152990016 Common rplL 50S ribosomal protein L7/L12 NIS_0267 208 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 152991341 Nonpathogen - hypothetical protein NIS_1600 2 None None None 152989901 Common - hypothetical protein NIS_0151 8 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152989816 Common - RNA pseudouridine synthase NIS_0064 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 152991335 Common - hypothetical protein NIS_1594 55 COG3213 NnrS, Uncharacterized protein involved in response to NO Inorganic ion transport and metabolism 152990118 Common - methyl-accepting chemotaxis protein NIS_0369 123 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152990903 Common - sodium:sulphate symporter NIS_1159 126 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 152990611 Common - chemotaxis protein methyltransferase NIS_0864 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 152991268 Common - S-adenosylmethionine decarboxylase NIS_1526 77 COG1586 SpeD, S-adenosylmethionine decarboxylase Amino acid transport and metabolism 152990536 Common - transcriptional regulator, ExsB family NIS_0789 179 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 152990102 Common - transcriptional regulator, PemK family NIS_0353 51 COG2337 MazF, Growth inhibitor Signal transduction mechanisms 152990508 Common tyrS tyrosyl-tRNA synthetase NIS_0761 240 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152990819 Common - two-component response regulator NIS_1075 222 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152990770 Common - polyprenyl synthetase NIS_1025 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 152990947 Nonpathogen - hypothetical protein NIS_1203 6 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 152990928 Common - 3-deoxy-7-phosphoheptulonate synthase, class II NIS_1184 73 COG3200 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 152991419 Common - hypothetical protein NIS_1678 72 COG1479 COG1479, Uncharacterized conserved protein Function unknown 152991544 Common napF periplasmic nitrate reductase, ferredoxin-type protein NapF NIS_1804 56 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 152989860 Common thrS threonyl-tRNA synthetase NIS_0108 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152991521 Common - hypothetical protein NIS_1781 10 COG4314 NosL, Predicted lipoprotein involved in nitrous oxide reduction Energy production and conversion 152990496 Common - hypothetical protein NIS_0749 24 None None None 152990196 Nonpathogen - hypothetical protein NIS_0447 1 None None None 152991159 Common - phosphoesterase, Pap2 family NIS_1417 74 None None None 152990677 Common - pyruvate/2-oxoglutarate dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase NIS_0931 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 152991435 Common - hypothetical protein NIS_1694 12 COG5633 COG5633, Predicted periplasmic lipoprotein General function prediction only 152990844 Common mviN virulence factor MviN NIS_1100 160 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 152990428 Common - hypothetical protein NIS_0679 24 None None None 152991244 Common - 16S rRNA processing protein RimM NIS_1502 83 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 152991372 Common - multidrug-efflux transporter, MFS family NIS_1631 201 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152990448 Common dapA dihydrodipicolinate synthase NIS_0699 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 152991463 Common - transcriptional regulator, TetR family NIS_1722 3 COG1309 AcrR, Transcriptional regulator Transcription 152990651 Common - hypothetical protein NIS_0905 4 None None None 152990777 Common ftsA cell division protein FtsA NIS_1032 178 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 152990114 Common - hypothetical protein NIS_0365 12 COG3893 COG3893, Inactivated superfamily I helicase DNA replication, recombination, and repair 152990814 Common - hypothetical protein NIS_1069 10 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 152989767 Common - hypothetical protein NIS_0014 44 COG3247 HdeD, Uncharacterized conserved protein Function unknown 152991237 Common argS arginyl-tRNA synthetase NIS_1495 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152990184 Common prsA ribose-phosphate pyrophosphokinase NIS_0435 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 152990160 Common - two-component response regulator NIS_0411 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152990159 Common - two-component sensor histidine kinase NIS_0410 216 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152990416 Common - acriflavin resistance protein, AcrB/AcrD/AcrF family NIS_0667 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 152990043 Common - NADH-quinone oxidoreductase, chain G NIS_0294 183 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 152990902 Common - DNA processing protein A NIS_1158 209 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 152991415 Common - antimicrobial peptide ABC transporter, permease NIS_1674 170 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 152991481 Common - K+ transport system, membrane component NIS_1741 123 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 152990489 Nonpathogen - hypothetical protein NIS_0740 3 None None None 152990469 Common - hypothetical protein NIS_0720 8 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 152990445 Common - membrane-associated zinc metalloprotease NIS_0696 210 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 152991563 Nonpathogen - hypothetical protein NIS_1824 3 COG3439 COG3439, Uncharacterized conserved protein Function unknown 152989867 Common - two-component sensor histidine kinase NIS_0117 187 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152990191 Nonpathogen - hypothetical protein NIS_0442 1 None None None 152989962 Common - hypothetical protein NIS_0213 13 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 152991434 Common - hypothetical protein NIS_1693 19 COG3014 COG3014, Uncharacterized protein conserved in bacteria Function unknown 152990083 Nonpathogen - hypothetical protein NIS_0334 2 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 152991392 Common topA DNA topoisomerase I NIS_1651 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 152990497 Common - ATP-dependent Lon-type protease NIS_0750 30 COG4930 COG4930, Predicted ATP-dependent Lon-type protease Posttranslational modification, protein turnover, chaperones 152990841 Common ddlA D-alanine-D-alanine ligase NIS_1097 212 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 152990676 Common - H+-transporting P-type ATPase NIS_0930 232 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 152990690 Common - glucose-6-phosphate isomerase NIS_0945 210 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 152990849 Common uppS undecaprenyl diphosphate synthase NIS_1105 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 152990954 Nonpathogen - hypothetical protein NIS_1210 2 None None None 152990796 Common - hypothetical protein NIS_1051 5 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 152990372 Common - flagellar hook-basal body complex protein FliE NIS_0623 46 COG1677 FliE, Flagellar hook-basal body protein Cell motility and secretion / Intracellular trafficking and secretion 152990593 Common ubiD 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiD NIS_0846 153 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 152990573 Common - cell division protein FtsK NIS_0826 199 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 152990965 Common atpG F0F1-type ATP synthase, gamma subunit NIS_1221 207 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 152991589 Nonpathogen - hypothetical protein NIS_1850 1 None None None 152990830 Common pdxJ pyridoxine 5-phosphate synthase NIS_1086 139 COG0854 PdxJ, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 152991251 Common - hypothetical protein NIS_1509 38 COG1579 COG1579, Zn-ribbon protein, possibly nucleic acid-binding General function prediction only 152991440 Nonpathogen - hypothetical protein NIS_1699 1 None None None 152990689 Common - glycogen/starch/alpha-glucan phosphorylase NIS_0944 86 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 152991189 Common - phosphoheptose isomerase NIS_1447 124 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 152990837 Common - UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate--D-alanyl-D-alanine ligase NIS_1093 189 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 152991167 Common - two-component sensor histidine kinase NIS_1425 217 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152991519 Common - hypothetical protein NIS_1779 10 COG4314 NosL, Predicted lipoprotein involved in nitrous oxide reduction Energy production and conversion 152990429 Common - hypothetical protein NIS_0680 29 COG2930 COG2930, Uncharacterized conserved protein Function unknown 152991574 Common - hypothetical protein NIS_1835 5 None None None 152990907 Common - hypothetical protein NIS_1163 9 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 152990409 Common pheT phenylalanyl-tRNA synthetase, beta subunit NIS_0660 228 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 152991409 Common - fibronectin/fibrinogen binding protein NIS_1668 56 COG1293 COG1293, Predicted RNA-binding protein homologous to eukaryotic snRNP Transcription 152990680 Common - pyruvate/2-oxoglutarate dehydrogenase complex, E1 component, alpha subunit NIS_0934 156 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 152989800 Common - ribonucleoside-diphosphate reductase, beta subunit NIS_0047 160 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 152990242 Common glnB nitrogen regulatory protein P-II NIS_0493 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 152991011 Common - hypothetical protein NIS_1268 6 None None None 152990549 Common - phosphatidylserine decarboxylase NIS_0802 91 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 152991069 Nonpathogen - hypothetical protein NIS_1326 1 None None None 152991006 Common - hypothetical protein NIS_1263 3 None None None 152990925 Common aroE shikimate 5-dehydrogenase NIS_1181 224 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 152991507 Common - hypothetical protein NIS_1767 11 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152991230 Nonpathogen - hypothetical protein NIS_1488 2 None None None 152990210 Nonpathogen - hypothetical protein NIS_0461 1 None None None 152991155 Common - general glycosylation pathway protein NIS_1413 13 None None None 152990176 Common xseA exodeoxyribonuclease VII, large subunit NIS_0427 201 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 152990025 Nonpathogen - hypothetical protein NIS_0276 1 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 152990405 Nonpathogen - hypothetical protein NIS_0656 1 None None None 152990862 Common msrA peptide methionine sulfoxide reductase NIS_1118 205 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 152991530 Common - uroporphyrin-III C-methyltransferase NIS_1790 204 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 152991131 Common - hypothetical protein NIS_1388 72 None None None 152991357 Common ccoQ cytochrome c oxidase, cbb3-type, subunit IV NIS_1616 7 COG4736 CcoQ, Cbb3-type cytochrome oxidase, subunit 3 Posttranslational modification, protein turnover, chaperones 152991512 Common - 5-oxoprolinase (ATP-hydrolyzing) NIS_1772 114 COG0146 HyuB, N-methylhydantoinase B/acetone carboxylase, alpha subunit Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152990826 Common - mechanosensitive ion channel NIS_1082 28 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 152990744 Common rplI 50S ribosomal protein L9 NIS_0999 212 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 152990795 Common - hypothetical protein NIS_1050 60 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 152991462 Common - multidrug-efflux transporter, MFS family NIS_1721 145 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 152990099 Common - Mn2+/Zn2+ ABC transporter, substrate-binding protein NIS_0350 158 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 152990013 Common rplK 50S ribosomal protein L11 NIS_0264 249 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 152989881 Nonpathogen - hypothetical protein NIS_0131 1 None None None 152991456 Common - two-component sensor histidine kinase NIS_1715 205 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152990551 Common - hypothetical protein NIS_0804 6 None None None 152989889 Common - nucleotidyltransferase, substrate-binding protein NIS_0139 31 None None None 152991527 Common - nitrous oxidase accessory protein NosD NIS_1787 48 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 152990198 Common - phage-related DNA-binding protein NIS_0449 3 None None None 152990612 Common phnA alkylphosphonate uptake protein PhnA NIS_0865 105 COG2824 PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism Inorganic ion transport and metabolism 152990869 Common - hypothetical protein NIS_1125 90 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 152990890 Common queA S-adenosylmethionine:tRNA ribosyltransferase-isomerase NIS_1146 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 152991052 Common - methylenetetrahydrofolate reductase NIS_1309 54 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 152990130 Common aat leucyl/phenylalanyl-tRNA--protein transferase NIS_0381 134 COG2360 Aat, Leu/Phe-tRNA-protein transferase Posttranslational modification, protein turnover, chaperones 152991406 Nonpathogen - hypothetical protein NIS_1665 1 None None None 152990775 Common bioA adenosylmethionine--8-amino-7-oxononanoate transaminase NIS_1030 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 152991307 Common - hypothetical protein NIS_1565 4 None None None 152989849 Common - hypothetical protein NIS_0097 105 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 152989872 Common - transcription regulator, Sir2 family NIS_0122 143 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 152990288 Common - hypothetical protein NIS_0539 67 COG1636 COG1636, Uncharacterized protein conserved in bacteria Function unknown 152989932 Common - hypothetical protein NIS_0183 15 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 152990223 Nonpathogen - hypothetical protein NIS_0474 1 None None None 152990304 Common - UTP--glucose-1-phosphate uridylyltransferase NIS_0555 231 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 152990625 Common rpmH 50S ribosomal protein L34 NIS_0878 199 None None None 152989756 Common gyrB DNA gyrase subunit B NIS_0003 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 152991286 Common hisI histidine biosynthesis bifunctional protein HisI NIS_1544 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 152990033 Nonpathogen - hypothetical protein NIS_0284 1 None None None 152990532 Common - calcium:H+/Na+ antiporter, CaCA family NIS_0785 125 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 152990157 Common - guanosine pentaphosphate phosphohydrolase NIS_0408 184 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 152990589 Common - 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit NIS_0842 113 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 152991366 Common purA adenylosuccinate synthetase NIS_1625 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 152990748 Common - hypothetical protein NIS_1003 5 None None None 152990061 Common mraY phospho-N-acetylmuramoyl-pentapeptide- transferase NIS_0312 225 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 152989840 Common - hypothetical protein NIS_0088 8 None None None 152990206 Nonpathogen - hypothetical protein NIS_0457 1 None None None 152990128 Common clpS ATP-dependent Clp protease, adaptor protein ClpS NIS_0379 118 COG2127 COG2127, Uncharacterized conserved protein Function unknown 152990752 Common - hypothetical protein NIS_1007 4 COG2842 COG2842, Uncharacterized ATPase, putative transposase General function prediction only 152990896 Common - thiosulfate sulfurtransferase NIS_1152 136 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152990103 Common - hypothetical protein NIS_0354 16 None None None 152991320 Common - molybdopterin biosynthesis protein MoeA NIS_1578 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 152991022 Common - O-acetylhomoserine sulfhydrylase NIS_1279 206 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 152990020 Common rpsG 30S ribosomal protein S7 NIS_0271 233 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 152990088 Common - DNA uptake protein NIS_0339 57 COG0658 ComEC, Predicted membrane metal-binding protein General function prediction only 152989925 Common - thioredoxin NIS_0176 232 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 152990340 Common - von Willebrand factor type A domain protein NIS_0591 92 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 152990945 Common gltB glutamate synthase (NADPH), large chain NIS_1201 204 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 152989861 Common infC translation initiation factor IF-3 NIS_0109 211 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 152990449 Common - peptidase, M16 family NIS_0700 184 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 152991066 Nonpathogen - hypothetical protein NIS_1323 1 None None None 152990221 Common - hypothetical protein NIS_0472 6 None None None 152989870 Common - signal transduction response regulator NIS_0120 168 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152989934 Nonpathogen - hypothetical protein NIS_0185 1 None None None 152990634 Common - aspartoacylase NIS_0887 18 COG2988 COG2988, Succinylglutamate desuccinylase Amino acid transport and metabolism 152991348 Common - oligopeptide ABC transporter, substrate-binding protein NIS_1607 213 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 152990349 Common - hypothetical protein NIS_0600 82 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152989904 Common - hypothetical protein NIS_0154 153 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 152990473 Common rpoD RNA polymerase sigma 70 factor NIS_0724 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 152991079 Common - organic solvent tolerance protein NIS_1336 95 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 152991072 Nonpathogen - hypothetical protein NIS_1329 1 None None None 152990377 Common - flagellar basal body and hook protein FlgE NIS_0628 126 COG1749 FlgE, Flagellar hook protein FlgE Cell motility and secretion 152990864 Common - hypothetical protein NIS_1120 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152989890 Common - nucleotidyltransferase NIS_0140 9 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 152990354 Nonpathogen - hypothetical protein NIS_0605 1 None None None 152990001 Common - hypothetical protein NIS_0252 7 None None None 152991467 Common - multidrug ABC transporter NIS_1726 106 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 152990582 Common mdh malate dehydrogenase, NAD-dependent NIS_0835 204 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 152989842 Common - hypothetical protein NIS_0090 51 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 152989984 Common rplE 50S ribosomal protein L5 NIS_0235 248 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 152989825 Common - transcriptional regulator, TetR family NIS_0073 137 COG1309 AcrR, Transcriptional regulator Transcription 152990981 Common dapE succinyl-diaminopimelate desuccinylase NIS_1237 219 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 152991389 Common - hypothetical protein NIS_1648 150 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 152991374 Common - molybdopterin biosynthesis protein NIS_1633 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 152990101 Common - hypothetical protein NIS_0352 4 COG4456 VagC, Virulence-associated protein and related proteins Function unknown 152990266 Common mutS DNA mismatch repair ATPase MutS NIS_0517 203 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 152991136 Common - glycosyl transferase NIS_1394 15 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152991315 Common - hypothetical protein NIS_1573 8 None None None 152989919 Common - hypothetical protein NIS_0170 222 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 152990495 Nonpathogen - hypothetical protein NIS_0748 1 None None None 152989770 Nonpathogen - hypothetical protein NIS_0017 1 None None None 152991429 Common - hypothetical protein NIS_1688 86 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 152991242 Common rplS 50S ribosomal protein L19 NIS_1500 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 152991003 Common - N terminal of UDP-glucose/GDP-mannose dehydrogenase NIS_1260 200 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 152991537 Nonpathogen - hypothetical protein NIS_1797 3 None None None 152990558 Common ilvH acetolactate synthase, small subunit NIS_0811 191 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 152990211 Common - hypothetical protein NIS_0462 24 COG4983 COG4983, Uncharacterized conserved protein Function unknown 152990090 Common glcD glycolate oxidase, subunit GlcD NIS_0341 201 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 152989789 Nonpathogen - hypothetical protein NIS_0036 2 None None None 152990534 Common - methyl-accepting chemotaxis protein NIS_0787 155 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152989992 Common map methionine aminopeptidase NIS_0243 249 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 152991031 Common - two-component response regulator NIS_1288 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152990320 Common - 4Fe-4S ferredoxin NIS_0571 171 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 152990810 Common - acetylornithine/succinylornithine aminotransferase NIS_1065 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 152990146 Common rpmF 50S ribosomal protein L32 NIS_0397 7 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 152990281 Common - hypothetical protein NIS_0532 11 None None None 152991037 Common - hypothetical protein NIS_1294 5 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 152989778 Common - hypothetical protein NIS_0025 15 None None None 152990132 Common pilT twitching motility protein PilT NIS_0383 170 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 152991399 Common recA DNA recombination protein RecA NIS_1658 230 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 152989946 Common - hypothetical protein NIS_0197 18 None None None 152991445 Common - type I restriction-modification system, S subunit NIS_1704 70 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 152991350 Common rpsI 30S ribosomal protein S9 NIS_1609 248 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 152990329 Nonpathogen - hypothetical protein NIS_0580 3 None None None 152990462 Common citE citrate lyase beta chain NIS_0713 103 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 152990482 Common - FAD dependent oxidoreductase NIS_0733 13 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 152990524 Common - imidazoleglycerol-phosphate dehydratase NIS_0777 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 152990238 Common gyrA DNA gyrase subunit A NIS_0489 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 152990217 Common - hypothetical protein NIS_0468 6 None None None 152991572 Common - two-component sensor histidine kinase NIS_1833 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152990578 Common - hypothetical protein NIS_0831 171 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 152991083 Common - Na+:H+ antiporter, NhaD family NIS_1340 60 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 152991453 Common suhB inositol-phosphate phosphatase NIS_1712 215 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 152989897 Common - hypothetical protein NIS_0147 8 None None None 152991216 Common - tRNA pseudouridine synthase B NIS_1474 233 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 152990725 Common - transcriptional regulator, TetR family NIS_0980 114 COG1309 AcrR, Transcriptional regulator Transcription 152990709 Common - Ni-Fe hydrogenase, large subunit NIS_0964 103 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 152990669 Common ppsA phosphoenolpyruvate synthase NIS_0923 236 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 152991113 Common trpS tryptophanyl-tRNA synthetase NIS_1370 249 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152991027 Nonpathogen - hypothetical protein NIS_1284 1 None None None 152990571 Common minE cell division topological specificity factor MinE NIS_0824 3 COG0851 MinE, Septum formation topological specificity factor Cell division and chromosome partitioning 152990716 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase NIS_0971 181 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 152990700 Common cbpA co-chaperone-curved DNA binding protein A NIS_0955 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 152991274 Common - hypothetical protein NIS_1532 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152991179 Nonpathogen - hypothetical protein NIS_1437 1 None None None 152990991 Common - aminotransferase NIS_1248 193 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 152990711 Common - hydrogenase expression/formation protease NIS_0966 73 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 152990297 Common - signal transduction sensor histidine kinase NIS_0548 118 COG2202 AtoS, FOG: PAS/PAC domain Signal transduction mechanisms 152990057 Nonpathogen - hypothetical protein NIS_0308 1 None None None 152990788 Common - tetraacyldisaccharide 4'-kinase NIS_1043 118 COG1663 LpxK, Tetraacyldisaccharide-1-P 4'-kinase Cell envelope biogenesis, outer membrane 152991383 Common - hypothetical protein NIS_1642 54 None None None 152990781 Common hemK protoporphyrinogen oxidase NIS_1036 234 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 152989838 Common - voltage-gated chloride channel NIS_0086 153 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 152991551 Common - hypothetical protein NIS_1811 155 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 152991190 Common - ADP-heptose synthase NIS_1448 175 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 152991394 Common bioB biotin synthase NIS_1653 171 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 152990023 Nonpathogen - hypothetical protein NIS_0274 1 None None None 152990782 Common - zinc-metallo protease NIS_1037 92 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 152991121 Nonpathogen - hypothetical protein NIS_1378 2 None None None 152990073 Common - hypothetical protein NIS_0324 11 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 152990766 Common - hypothetical protein NIS_1021 18 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 152990856 Common - glycosyl transferase NIS_1112 216 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152991263 Common - penicillin-binding protein 1A NIS_1521 206 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 152990883 Common - hypothetical protein NIS_1139 7 None None None 152990809 Common - hypothetical protein NIS_1064 9 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 152991249 Common - hypothetical protein NIS_1507 70 COG1872 COG1872, Uncharacterized conserved protein Function unknown 152990510 Common - N-acetylmuramoyl-L-alanine amidase NIS_0763 181 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 152991032 Common - two-component sensor histidine kinase NIS_1289 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152990507 Common - guanosine-3',5'-bis(diphosphate) 3'-diphosphatase NIS_0760 208 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 152991041 Common - hypothetical protein NIS_1298 45 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152990627 Common - hypothetical protein NIS_0880 80 COG0759 COG0759, Uncharacterized conserved protein Function unknown 152989954 Common - hypothetical protein NIS_0205 11 COG5607 COG5607, Uncharacterized conserved protein Function unknown 152990112 Common - hypothetical protein NIS_0363 3 None None None 152991004 Common - DNA mismatch repair protein NIS_1261 159 COG1193 COG1193, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 152990914 Common - transcriptional activator, Baf family NIS_1170 11 COG1521 COG1521, Putative transcriptional regulator, homolog of Bvg accessory factor Transcription 152989837 Nonpathogen - hypothetical protein NIS_0085 1 None None None 152991295 Common - homoserine dehydrogenase NIS_1553 217 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 152989898 Common - cytochrome bd oxidase subunit I NIS_0148 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 152991184 Common - glycosyl transferase NIS_1442 166 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152991576 Common - hypothetical protein NIS_1837 115 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 152990519 Common - NAD+ kinase NIS_0772 239 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 152991055 Common argC N-acetyl-gamma-glutamyl-phosphate reductase NIS_1312 217 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 152990396 Common glmS glucosamine--fructose-6-phosphate aminotransferase NIS_0647 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 152991226 Common - hypothetical protein NIS_1484 7 None None None 152990998 Common - hypothetical protein NIS_1255 41 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 152990270 Common acs acetyl-CoA synthetase NIS_0521 216 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 152991172 Common - nitrogen regulatory protein P-II NIS_1430 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 152990275 Common - hypothetical protein NIS_0526 7 None None None 152990872 Common - signal transduction response regulator NIS_1128 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152989852 Common speE spermidine synthase NIS_0100 135 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 152991099 Common recG ATP-dependent DNA recombinase RecG NIS_1356 210 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 152990251 Nonpathogen - hypothetical protein NIS_0502 3 None None None 152991330 Common - riboflavin synthase, alpha subunit NIS_1588 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 152990290 Common lpxA acyl-[acyl-carrier-protein]--UDP-N- acetylglucosam O-acyltransferase NIS_0541 182 COG1043 LpxA, Acyl- acyl carrier protein 152991231 Common fabI enoyl-[acyl-carrier protein] reductase (NADH) NIS_1489 234 COG0623 FabI, Enoyl- acyl-carrier-protein 152991379 Common - cytochrome c peroxidase NIS_1638 94 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 152990888 Common - twin-arginine translocation system component TatB NIS_1144 67 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 152990313 Common - hypothetical protein NIS_0564 23 COG3034 COG3034, Uncharacterized protein conserved in bacteria Function unknown 152989994 Common rpmJ 50S ribosomal protein L36 NIS_0245 137 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 152990124 Common - anthranilate/para-aminobenzoate synthase component I NIS_0375 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 152990407 Common - histidine triad family protein NIS_0658 234 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 152990505 Common pyrH uridylate kinase NIS_0758 236 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 152990485 Common - multidrug ABC transporter, ATP-binding protein NIS_0736 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 152990937 Common - hypothetical protein NIS_1193 3 None None None 152990956 Common slyD FKBP-type peptidyl-prolyl cis-trans isomerase SlyD NIS_1212 136 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 152991449 Common radC DNA repair protein RadC NIS_1708 178 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 152990692 Common - glycogen/starch/alpha-glucan phosphorylase NIS_0947 150 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 152990847 Common glmU glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase NIS_1103 232 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 152990464 Common - Ni-Fe hydrogenase, large subunit HycE NIS_0715 186 COG3261 HycE, Ni,Fe-hydrogenase III large subunit Energy production and conversion 152990750 Common - hypothetical protein NIS_1005 3 None None None 152990923 Common - hypothetical protein NIS_1179 5 COG3147 DedD, Uncharacterized protein conserved in bacteria Function unknown 152991442 Common - molybdenum cofactor biosynthesis protein C NIS_1701 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 152989923 Common thiG thiamine biosynthesis protein ThiG NIS_0174 166 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 152990403 Common - hypothetical protein NIS_0654 6 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 152990801 Common - signal recognition particle receptor FtsY NIS_1056 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 152991479 Common - transcriptional regulator, TetR family NIS_1738 54 COG1309 AcrR, Transcriptional regulator Transcription 152990008 Common - hypothetical protein NIS_0259 87 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 152990835 Common - histidine triad family protein NIS_1091 98 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 152989999 Common rplQ 50S ribosomal protein L17 NIS_0250 215 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 152990491 Common - transposase NIS_0743 20 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 152990244 Nonpathogen - hypothetical protein NIS_0495 1 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152991451 Common - hypothetical protein NIS_1710 3 None None None 152989909 Common - hypothetical protein NIS_0159 3 None None None 152991067 Nonpathogen - hypothetical protein NIS_1324 2 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 152990451 Common trmA tRNA (uracil-5-)-methyltransferase NIS_0702 183 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 152989829 Nonpathogen - hypothetical protein NIS_0077 13 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 152990479 Common - tRNA/rRNA methyltransferase NIS_0730 158 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 152991153 Common hisA phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide NIS_1411 215 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 152991092 Common - hypothetical protein NIS_1349 17 COG4105 ComL, DNA uptake lipoprotein General function prediction only 152989865 Common - ABC transporter, permease NIS_0113 38 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 152991540 Common - hypothetical protein NIS_1800 16 None None None 152990360 Common - flagellar protein FlgA NIS_0611 26 COG1261 FlgA, Flagellar basal body P-ring biosynthesis protein Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 152990203 Nonpathogen - hypothetical protein NIS_0454 3 None None None 152991312 Common - hypothetical protein NIS_1570 2 None None None 152990047 Common nuoJ NADH-quinone oxidoreductase, chain J NIS_0298 51 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 152990644 Common pfkA 6-phosphofructokinase NIS_0897 157 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 152991235 Common nadD nicotinate-nucleotide adenylyltransferase NIS_1493 194 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 152989854 Common dapF diaminopimelate epimerase NIS_0102 195 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 152990816 Common - hypothetical protein NIS_1071 3 COG3133 SlyB, Outer membrane lipoprotein Cell envelope biogenesis, outer membrane 152990900 Common - peptidase S1, chymotrypsin NIS_1156 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 152990369 Common - hypothetical protein NIS_0620 5 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 152991460 Common - hypothetical protein NIS_1719 19 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 152990162 Common - hypothetical protein NIS_0413 169 COG0344 COG0344, Predicted membrane protein Function unknown 152991483 Common - voltage-gated chloride channel NIS_1743 164 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 152990193 Nonpathogen - hypothetical protein NIS_0444 1 None None None 152990912 Common - hypothetical protein NIS_1168 25 COG4976 COG4976, Predicted methyltransferase (contains TPR repeat) General function prediction only 152990067 Common argJ arginine biosynthesis bifunctional protein ArgJ NIS_0318 167 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 152989883 Common - hypothetical protein NIS_0133 10 None None None 152990443 Common - signal transduction response regulator NIS_0694 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152991182 Nonpathogen - hypothetical protein NIS_1440 2 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 152989910 Common - arginine-tRNA-protein transferase NIS_0160 85 COG2935 COG2935, Putative arginyl-tRNA:protein arginylyltransferase Posttranslational modification, protein turnover, chaperones 152989964 Common rnc ribonuclease III NIS_0215 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 152990414 Common - outer membrane efflux protein NIS_0665 42 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 152990279 Common - histidine triad family protein NIS_0530 56 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 152991547 Common napG periplasmic nitrate reductase, ferredoxin-type protein NapG NIS_1807 56 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 152991206 Common leuS leucyl-tRNA synthetase NIS_1464 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152989809 Common - hypothetical protein NIS_0057 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 152991549 Common - hypothetical protein NIS_1809 16 None None None 152990081 Nonpathogen - hypothetical protein NIS_0332 2 None None None 152990031 Common - hypothetical protein NIS_0282 46 COG1656 COG1656, Uncharacterized conserved protein Function unknown 152991542 Common - periplasmic nitrate reductase component NapD NIS_1802 8 COG3062 NapD, Uncharacterized protein involved in formation of periplasmic nitrate reductase Inorganic ion transport and metabolism 152991059 Common - oxidoreductase NIS_1316 182 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152990773 Common - hypothetical protein NIS_1028 5 None None None 152990674 Common - decarboxylase family protein NIS_0928 110 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 152990306 Common pepD aminoacyl-histidine dipeptidase NIS_0557 53 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 152991288 Common - hypothetical protein NIS_1546 94 COG1242 COG1242, Predicted Fe-S oxidoreductase General function prediction only 152991579 Common - methyl transferase NIS_1840 18 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 152991364 Common carA carbamoylphosphate synthase, small subunit NIS_1623 233 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 152991289 Common purF amidophosphoribosyltransferase NIS_1547 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 152990997 Common - hypothetical protein NIS_1254 2 None None None 152991431 Common - hypothetical protein NIS_1690 2 None None None 152991282 Common - two-component response regulator NIS_1540 181 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152991582 Common frr ribosome recycling factor Frr NIS_1843 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 152989827 Common - hypothetical protein NIS_0075 128 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 152990580 Common - hypothetical protein NIS_0833 184 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 152990587 Common - hypothetical protein NIS_0840 6 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 152991465 Common - hypothetical protein NIS_1724 73 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 152989758 Common - GTP cyclohydrolase I NIS_0005 90 COG0780 COG0780, Enzyme related to GTP cyclohydrolase I General function prediction only 152991196 Common - hypothetical protein NIS_1454 4 None None None 152990232 Common - hypothetical protein NIS_0483 14 COG3926 zliS, Putative secretion activating protein General function prediction only 152990418 Common - hypothetical protein NIS_0669 3 COG3071 HemY, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 152991258 Common - peptidase, U32 family NIS_1516 140 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 152989776 Common - metal ion ABC transporter, permease NIS_0023 64 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 152990960 Common - hypothetical protein NIS_1216 5 None None None 152990682 Common glgB 1,4-alpha-glucan branching enzyme NIS_0936 152 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 152991248 Common - ribosomal large subunit pseudouridine synthase, RluD subfamily NIS_1506 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 152990726 Common - site-specific recombinase, phage integrase family NIS_0981 221 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 152990480 Common - hypothetical protein NIS_0731 6 COG1988 COG1988, Predicted membrane-bound metal-dependent hydrolases General function prediction only 152990754 Common - hypothetical protein NIS_1009 3 None None None 152990665 Common - hypothetical protein NIS_0919 126 COG1509 KamA, Lysine 2,3-aminomutase Amino acid transport and metabolism 152990530 Nonpathogen - hypothetical protein NIS_0783 1 None None None 152991420 Nonpathogen - hypothetical protein NIS_1679 1 None None None 152991329 Common gidA glucose inhibited division protein A NIS_1587 194 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 152990793 Common - hypothetical protein NIS_1048 110 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 152991514 Nonpathogen - hypothetical protein NIS_1774 2 None None None 152991436 Common - hypothetical protein NIS_1695 16 COG3417 FlgN, Collagen-binding surface adhesin SpaP (antigen I/II family) General function prediction only 152990325 Common - cytochrome c, class I NIS_0576 37 COG2863 COG2863, Cytochrome c553 Energy production and conversion 152991505 Common - hypothetical protein NIS_1765 30 COG4886 COG4886, Leucine-rich repeat (LRR) protein Function unknown 152991520 Common - ABC transporter, permease NIS_1780 53 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 152990824 Common - ATP-dependent zinc metalloproteinase NIS_1080 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 152991146 Common - glycosyl transferase NIS_1404 176 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152989892 Common tas aldo/keto reductase-family protein NIS_0142 202 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152990487 Common - hypothetical protein NIS_0738 75 COG2989 COG2989, Uncharacterized protein conserved in bacteria Function unknown 152990721 Common - hydrogenase expression/formation protein HypD NIS_0976 109 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 152991203 Common - transcription-repair coupling factor NIS_1461 228 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 152989786 Common - sulfur oxidation protein, Rieske-I iron sulfur protein SoxL NIS_0033 14 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 152989982 Common rplN 50S ribosomal protein L14 NIS_0233 247 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 152990150 Common - hypothetical protein NIS_0401 95 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 152990516 Common - adenylate kinase NIS_0769 230 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 152990011 Common secE preprotein translocase subunit E NIS_0262 2 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 152990069 Common rpe ribulose-phosphate 3-epimerase NIS_0320 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 152990623 Common clpB ATP-dependent Clp protease, ATP-binding subunit ClpB NIS_0876 216 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 152990821 Common - hypothetical protein NIS_1077 21 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 152991142 Nonpathogen - hypothetical protein NIS_1400 4 None None None 152990610 Nonpathogen - hypothetical protein NIS_0863 1 None None None 152990553 Common - ferrous iron transport protein B NIS_0806 177 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 152990097 Common - Mn2+/Zn2+ ABC transporter, permease NIS_0348 162 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 152989794 Nonpathogen - hypothetical protein NIS_0041 5 None None None 152991305 Common - general secretory pathway protein E NIS_1563 216 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 152990431 Common - riboflavin biosynthesis bifunctional protein RibBA NIS_0682 229 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 152990526 Nonpathogen - hypothetical protein NIS_0779 1 COG5375 COG5375, Uncharacterized protein conserved in bacteria Function unknown 152990493 Nonpathogen - hypothetical protein NIS_0745 1 None None None 152990170 Common infB translation initiation factor IF-2 NIS_0421 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 152991001 Common - hypothetical protein NIS_1258 34 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152991385 Common accC acetyl-CoA carboxylase, biotin carboxylase NIS_1644 238 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 152991077 Common - heat shock protein NIS_1334 14 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 152990977 Common rpmA 50S ribosomal protein L27 NIS_1233 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 152990277 Common - two-component sensor histidine kinase NIS_0528 169 COG4564 COG4564, Signal transduction histidine kinase Signal transduction mechanisms 152990095 Common - globin NIS_0346 9 COG2346 COG2346, Truncated hemoglobins General function prediction only 152990591 Common - 2-oxoglutarate ferredoxin oxidoreductase, gamma subunit NIS_0844 68 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 152990939 Common - hypothetical protein NIS_1195 7 None None None 152990323 Common - hypothetical protein NIS_0574 4 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 152989936 Common - hypothetical protein NIS_0187 3 None None None 152991447 Common - death-on-curing family protein NIS_1706 72 COG3943 COG3943, Virulence protein General function prediction only 152990683 Common - glycogen synthase NIS_0937 143 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 152989948 Common gph HAD-superfamily hydrolase NIS_0199 177 COG0546 Gph, Predicted phosphatases General function prediction only 152990663 Common - protein-glutamate methylesterase NIS_0917 149 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 152989961 Common dnaG DNA primase DnaG NIS_0212 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 152990943 Common - inositol monophosphatase family protein NIS_1199 8 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 152991565 Common - hypothetical protein NIS_1826 14 COG2143 COG2143, Thioredoxin-related protein Posttranslational modification, protein turnover, chaperones 152991493 Common - two-component sensor histidine kinase NIS_1753 222 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 152990086 Common ispG 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase NIS_0337 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 152990707 Common - Ni-Fe hydrogenase, large subunit HupV NIS_0962 100 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 152991105 Common - hypothetical protein NIS_1362 15 COG2445 COG2445, Uncharacterized conserved protein Function unknown 152990866 Common grpE co-chaperone protein GrpE NIS_1122 223 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 152991484 Common - hypothetical protein NIS_1744 40 COG2836 COG2836, Uncharacterized conserved protein Function unknown 152990177 Common - protease IV NIS_0428 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 152991474 Common - nitrate/sulfonate/bicarbonate ABC transporter, substrate-binding protein NIS_1733 5 None None None 152989906 Common pyrG CTP synthetase NIS_0156 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 152990110 Common - ornithine carbamoyltransferase NIS_0361 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 152991525 Common - hypothetical protein NIS_1785 8 COG2863 COG2863, Cytochrome c553 Energy production and conversion 152990475 Common leuD 3-isopropylmalate dehydratase, small subunit NIS_0726 161 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 152990441 Common - tRNA pseudouridine synthase D NIS_0692 87 COG0585 COG0585, Uncharacterized conserved protein Function unknown 152990615 Nonpathogen - hypothetical protein NIS_0868 3 None None None 152989813 Common ksgA dimethyladenosine transferase NIS_0061 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 152990995 Common - hypothetical protein NIS_1252 25 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 152991070 Nonpathogen - hypothetical protein NIS_1327 1 None None None 152991017 Common - hydrolase, carbon-nitrogen family NIS_1274 71 COG0388 COG0388, Predicted amidohydrolase General function prediction only 152990655 Nonpathogen - hypothetical protein NIS_0909 1 None None None 152990106 Common - hypothetical protein NIS_0357 7 None None None 152991398 Common eno phosphopyruvate hydratase NIS_1657 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 152990041 Common - hypothetical protein NIS_0292 6 None None None 152990268 Nonpathogen - hypothetical protein NIS_0519 1 None None None 152989912 Common - signal transduction response regulator NIS_0162 179 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152990371 Common flgC flagellar basal-body rod protein FlgC NIS_0622 125 COG1558 FlgC, Flagellar basal body rod protein Cell motility and secretion 152991264 Common - ABC transporter, ATP-binding protein NIS_1522 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 152991162 Nonpathogen - hypothetical protein NIS_1420 1 None None None 152991369 Common - heat shock protein Hsp20 NIS_1628 166 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 152991151 Common - cell division protein FtsH NIS_1409 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 152990426 Common - shikimate kinase NIS_0677 169 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 152990630 Common trmE tRNA modification GTPase TrmE NIS_0883 222 COG0486 ThdF, Predicted GTPase General function prediction only 152990398 Common - nucleotide phosphoribosyltransferase NIS_0649 7 COG2236 COG2236, Predicted phosphoribosyltransferases General function prediction only 152990569 Common - hypothetical protein NIS_0822 3 COG0850 MinC, Septum formation inhibitor Cell division and chromosome partitioning 152990812 Nonpathogen - hypothetical protein NIS_1067 1 None None None 152990967 Common atpH F0F1-type ATP synthase, delta subunit NIS_1223 35 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 152990874 Common - hypothetical protein NIS_1130 105 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 152990854 Common - hypothetical protein NIS_1110 64 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 152990343 Common - two-component response regulator NIS_0594 175 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 152990336 Common - hypothetical protein NIS_0587 30 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 152990188 Common - hypothetical protein NIS_0439 76 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 152990930 Common dnaJ co-chaperone protein DnaJ NIS_1186 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 152990608 Common proA glutamate-5-semialdehyde dehydrogenase NIS_0861 189 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 152991400 Common - hypothetical protein NIS_1659 38 COG2107 COG2107, Predicted periplasmic solute-binding protein General function prediction only 152991336 Common - 2'-5' RNA ligase NIS_1595 43 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 152990316 Common - hypothetical protein NIS_0567 174 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152990560 Common - hypothetical protein NIS_0813 6 None None None 152991057 Common lpxB lipid A disaccharide synthetase NIS_1314 139 COG0763 LpxB, Lipid A disaccharide synthetase Cell envelope biogenesis, outer membrane 152989952 Common - hypothetical protein NIS_0203 3 None None None 152990283 Common - hypothetical protein NIS_0534 69 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 152991097 Common - hypothetical protein NIS_1354 4 None None None 152989966 Common - hypothetical protein NIS_0217 12 COG4487 COG4487, Uncharacterized protein conserved in bacteria Function unknown 152989796 Common pckA phosphoenolpyruvate carboxykinase [ATP] NIS_0043 98 COG1866 PckA, Phosphoenolpyruvate carboxykinase (ATP) Energy production and conversion 152990768 Common proS prolyl-tRNA synthetase NIS_1023 240 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152990637 Common - carboxypeptidase G2 NIS_0890 146 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 152990055 Nonpathogen - hypothetical protein NIS_0306 2 None None None 152990352 Common cheW purine-binding chemotaxis protein CheW NIS_0603 122 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 152990299 Common - hypothetical protein NIS_0550 181 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152990071 Common dnaQ DNA polymerase III, epsilon subunit NIS_0322 168 COG2176 PolC, DNA polymerase III, alpha subunit (gram-positive type) DNA replication, recombination, and repair 152990144 Common ndk nucleoside-diphosphate kinase NIS_0395 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 152989971 Common rpsJ 30S ribosomal protein S10 NIS_0222 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 152989760 Common - signal transduction sensor histidine kinase NIS_0007 180 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152991536 Common - nitric-oxide reductase, small subunit NIS_1796 36 COG3256 NorB, Nitric oxide reductase large subunit Inorganic ion transport and metabolism 152990390 Common - flagellar protein FlaG NIS_0641 39 COG1334 FlaG, Uncharacterized flagellar protein FlaG Cell motility and secretion 152991046 Common - Na+-transporting oxaloacetate decarboxylase, alpha subunit NIS_1303 190 COG5016 COG5016, Pyruvate/oxaloacetate carboxyltransferase Energy production and conversion 152991025 Common ileS isoleucyl-tRNA synthetase NIS_1282 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152991218 Common smpB ssrA RNA-binding protein NIS_1476 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 152991570 Common - sulfur oxidation protein SoxY NIS_1831 37 COG5501 COG5501, Predicted secreted protein Function unknown 152990784 Common - divalent cation transporter NIS_1039 120 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 152990050 Common nuoM NADH-quinone oxidoreductase, chain M NIS_0301 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 152991276 Common prfB peptide chain release factor 2 NIS_1534 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 152991339 Common - hypothetical protein NIS_1598 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152989765 Common - hypothetical protein NIS_0012 8 None None None 152991591 Common - HAD-superfamily hydrolase NIS_1852 169 COG0546 Gph, Predicted phosphatases General function prediction only 152990215 Common - hypothetical protein NIS_0466 2 None None None 152989959 Common dgkA diacylglycerol kinase NIS_0210 64 COG0818 DgkA, Diacylglycerol kinase Cell envelope biogenesis, outer membrane 152990718 Common - hypothetical protein NIS_0973 13 COG2215 COG2215, ABC-type uncharacterized transport system, permease component General function prediction only 152990021 Common fusA translation elongation factor G NIS_0272 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 152990636 Nonpathogen - hypothetical protein NIS_0889 1 None None None 152990330 Common - phosphate transport system regulator NIS_0581 143 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 152990122 Common panB 3-methyl-2-oxobutanoate hydroxymethyltransferase NIS_0373 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 152991127 Common - glycosyl transferase NIS_1384 211 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152989831 Common - cytochrome c biogenesis protein NIS_0079 15 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 152990477 Common - RNA nucleotidyltransferase NIS_0728 184 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 152991134 Common - hypothetical protein NIS_1391 126 None None None 152991503 Common - transcriptional regulator, PemK family NIS_1763 44 COG2337 MazF, Growth inhibitor Signal transduction mechanisms 152989976 Common rpsS 30S ribosomal protein S19 NIS_0227 243 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 152991115 Nonpathogen - nucleotide-binding protein NIS_1372 4 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 152991090 Common - hypothetical protein NIS_1347 222 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152990308 Common nth endonuclease III NIS_0559 240 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 152990181 Common folK 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase NIS_0432 182 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 152990910 Common rpsR 30S ribosomal protein S18 NIS_1166 210 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 152990060 Common murD UDP-N-acetylmuramoylalanine--D-glutamate ligase NIS_0311 209 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 152990107 Common gidB glucose inhibited division protein B NIS_0358 200 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 152991585 Common - nucleoside:H+ symporter NIS_1846 67 None None None 152991577 Common - hypothetical protein NIS_1838 20 None None None 152990227 Nonpathogen - phage-related tail protein NIS_0478 1 None None None 152990895 Common - bacterioferritin NIS_1151 55 COG2406 COG2406, Protein distantly related to bacterial ferritins General function prediction only 152991199 Common - DNA polymerase III, gamma/tau subunits NIS_1457 248 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 152991310 Nonpathogen - hypothetical protein NIS_1568 1 None None None 152990621 Common purC phosphoribosylaminoimidazole-succinocarboxamide synthase NIS_0874 220 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 152991208 Common secD preprotein translocase subunit D NIS_1466 221 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 152990017 Common rpoB DNA-directed RNA polymerase, beta subunit NIS_0268 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 152990737 Common - hypothetical protein NIS_0992 120 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 152991256 Common purE phosphoribosylaminoimidazole carboxylase, catalytic subunit NIS_1514 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 152991327 Common - ubiquinol-cytochrome c oxidoreductase, iron-sulfur subunit NIS_1585 115 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 152991229 Nonpathogen - hypothetical protein NIS_1487 3 None None None 152990723 Common - hydrogenase maturation protein HoxX NIS_0978 52 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 152990152 Common - von Willebrand factor type A domain protein NIS_0403 91 COG2425 COG2425, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 152989988 Common rplR 50S ribosomal protein L18 NIS_0239 213 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 152989845 Nonpathogen - hypothetical protein NIS_0093 2 None None None 152990829 Common tgt queuine tRNA-ribosyltransferase NIS_1085 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 152990220 Nonpathogen - hypothetical protein NIS_0471 2 None None None 152990249 Common - hypothetical protein NIS_0500 20 None None None 152991144 Common - type I secretion system membrane fusion protein NIS_1402 137 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 152991085 Common - hypothetical protein NIS_1342 5 None None None 152991148 Nonpathogen - hypothetical protein NIS_1406 2 None None None 152990730 Common - flagellar motor protein MotA NIS_0985 103 COG1291 MotA, Flagellar motor component Cell motility and secretion 152990555 Common tdcB threonine dehydratase NIS_0808 209 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 152990134 Common pth peptidyl-tRNA hydrolase, PTH1 family NIS_0385 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 152989790 Common - hypothetical protein NIS_0037 15 COG3972 COG3972, Superfamily I DNA and RNA helicases General function prediction only 152991222 Nonpathogen - hypothetical protein NIS_1480 1 None None None 152990201 Nonpathogen - hypothetical protein NIS_0452 4 COG1591 COG1591, Holliday junction resolvase - archaeal type DNA replication, recombination, and repair 152991164 Common - periplasmic protein TonB NIS_1422 27 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 152991367 Common - hypothetical protein NIS_1626 58 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152989795 Common - hypothetical protein NIS_0042 26 None None None 152990255 Common - copper resistance protein B NIS_0506 43 COG3667 PcoB, Uncharacterized protein involved in copper resistance Inorganic ion transport and metabolism 152990585 Common sucC succinyl-CoA synthase, beta subunit NIS_0838 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 152990300 Common - hypothetical protein NIS_0551 6 None None None 152991439 Common - molybdopterin-guanine dinucleotide biosynthesis protein A NIS_1698 57 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 152990684 Common - hypothetical protein NIS_0938 125 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 152990483 Common hemH ferrochelatase NIS_0734 175 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 152989884 Common - hypothetical protein NIS_0134 15 COG3439 COG3439, Uncharacterized conserved protein Function unknown 152991487 Nonpathogen - hypothetical protein NIS_1747 1 None None None 152990616 Common - hypothetical protein NIS_0869 101 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 152990037 Common nuoA NADH-quinone oxidoreductase, chain A NIS_0288 161 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 152990387 Nonpathogen - hypothetical protein NIS_0638 1 None None None 152991362 Common - TonB-dependent copper receptor NIS_1621 99 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 152990515 Common - molybdenum cofactor biosynthesis protein NIS_0768 146 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 152990411 Common ispH 4-hydroxy-3-methylbut-2-enyl diphosphate reductase NIS_0662 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 152990436 Common - uracil-DNA glycosylase NIS_0687 158 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 152990557 Common ilvI acetolactate synthase, large subunit NIS_0810 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 152991284 Common ilvE branched-chain amino acid aminotransferase NIS_1542 208 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 152990805 Common acpS holo-[acyl-carrier protein] synthase NIS_1060 105 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 152990931 Common - cytochrome c biogenesis protein, CcmF/CycK/CcsA family NIS_1187 93 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 152990756 Common - general secretory pathway protein F NIS_1011 145 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 152990121 Common ruvB holliday junction DNA helicase RuvB NIS_0372 225 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 152990647 Nonpathogen - hypothetical protein NIS_0901 2 COG3462 COG3462, Predicted membrane protein Function unknown 152991418 Common - hypothetical protein NIS_1677 8 None None None 152990440 Common - thiamin-monophosphate kinase NIS_0691 172 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 152990818 Common - S-adenosylmethionine synthetase NIS_1074 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 152990646 Common - two-component response regulator NIS_0899 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152990699 Common htpG heat shock protein HtpG NIS_0954 150 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 152990350 Common cheY chemotactic response regulator CheY NIS_0601 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152990886 Common - oxygen-independent coproporphyrinogen III oxidase NIS_1142 208 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 152990367 Common fliA RNA polymerase sigma factor for flagellar operon NIS_0618 192 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 152991411 Common sfsA sugar fermentation stimulation protein NIS_1670 101 COG1489 SfsA, DNA-binding protein, stimulates sugar fermentation General function prediction only 152991495 Common - cytochrome c NIS_1755 15 None None None 152990065 Common accA acetyl-CoA carboxylase, carboxyl transferase subunit alpha NIS_0316 177 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 152990165 Common - phosphoesterase NIS_0416 86 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 152989921 Common - hypothetical protein NIS_0172 61 COG3174 COG3174, Predicted membrane protein Function unknown 152990195 Common - hypothetical protein NIS_0446 2 None None None 152990969 Common - F0F1-type ATP synthase, B' subunit NIS_1225 19 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 152991472 Common - hypothetical protein NIS_1731 216 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 152990671 Common lipA lipoate synthase NIS_0925 191 COG0320 LipA, Lipoate synthase Coenzyme metabolism 152990149 Common - ATPase, AAA family NIS_0400 179 COG0714 COG0714, MoxR-like ATPases General function prediction only 152990380 Nonpathogen - flagellar biosynthesis protein FliZ NIS_0631 1 None None None 152991545 Common - periplasmic nitrate reductase, small subunit NIS_1805 41 COG3043 NapB, Nitrate reductase cytochrome c-type subunit Energy production and conversion 152990657 Common - heavy metal efflux pump, CzcB family NIS_0911 56 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 152990906 Common - ribonuclease NIS_1162 192 COG0557 VacB, Exoribonuclease R Transcription 152989803 Common - peptide methionine sulfoxide reductase NIS_0051 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 152990394 Common flgK flagellar hook-associated protein 1 FliK NIS_0645 119 COG1256 FlgK, Flagellar hook-associated protein Cell motility and secretion 152991595 Nonpathogen - hypothetical protein NIS_1856 1 None None None 152989782 Common - protein tyrosine phosphatase NIS_0029 122 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 152990545 Nonpathogen - hypothetical protein NIS_0798 3 None None None 152990941 Common - thiamine-phosphate pyrophosphorylase NIS_1197 98 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 152990337 Common - ATPase, AAA family NIS_0588 187 COG0714 COG0714, MoxR-like ATPases General function prediction only 152991266 Nonpathogen - hypothetical protein NIS_1524 10 COG2112 COG2112, Predicted Ser/Thr protein kinase Signal transduction mechanisms 152990778 Common ftsZ cell division protein FtsZ NIS_1033 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 152991234 Common - glyceraldehyde 3-phosphate dehydrogenase NIS_1492 218 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 152991054 Common - hypothetical protein NIS_1311 26 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 152991013 Common - aminotransferase, class I and II NIS_1270 240 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 152991128 Common - NAD-dependent epimerase/dehydratase NIS_1385 214 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152990693 Common purH bifunctional purine biosynthesis protein PurH NIS_0948 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 152990836 Common - C4-dicarboxylate transporter, permease NIS_1092 123 COG4664 FcbT3, TRAP-type mannitol/chloroaromatic compound transport system, large permease component Secondary metabolites biosynthesis, transport, and catabolism 152991019 Common - homoserine O-acetyltransferase NIS_1276 132 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 152990733 Common - GatB/Yqey domain protein NIS_0988 151 COG1610 COG1610, Uncharacterized conserved protein Function unknown 152990046 Common nuoI NADH-quinone oxidoreductase, chain I NIS_0297 188 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 152991555 Nonpathogen - hypothetical protein NIS_1815 11 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 152989863 Common rplT 50S ribosomal protein L20 NIS_0111 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 152990702 Common murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase NIS_0957 210 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 152991496 Common - alcohol dehydrogenase NIS_1756 80 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152989804 Common - hypothetical protein NIS_0052 116 COG2110 COG2110, Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 General function prediction only 152990401 Common - ATP citrate synthase, subunit 1 NIS_0652 123 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 152989967 Common rnhB ribonuclease HII NIS_0218 236 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 152990929 Common recR DNA recombination protein RecR NIS_1185 203 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 152990962 Common - biopolymer transport protein, ExbB/TolQ family NIS_1218 92 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 152991277 Common - ABC transporter, ATP-binding protein NIS_1535 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 152990453 Common - leucyl aminopeptidase NIS_0704 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 152991422 Common - phosphoadenosine phosphosulfate reductase NIS_1681 50 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 152989998 Common rpoA DNA-directed RNA polymerase, alpha subunit NIS_0249 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 152990704 Common - tellurite resistance protein TehB NIS_0959 46 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 152991126 Common - hypothetical protein NIS_1383 24 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 152991390 Common - divalent cation transporter NIS_1649 161 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 152990392 Common fliS flagellar protein FliS NIS_0643 59 COG1516 FliS, Flagellin-specific chaperone FliS Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 152991174 Common - nitrate transporter, NarK/NasA family NIS_1432 99 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 152991346 Common - pyruvate:ferredoxin oxidoreductase, gamma subunit NIS_1605 62 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 152990712 Common - hypothetical protein NIS_0967 104 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 152990772 Common - cation:multidrug efflux pump NIS_1027 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 152990213 Common - phage terminase, small subunit NIS_0464 13 COG3728 XtmA, Phage terminase, small subunit DNA replication, recombination, and repair 152991211 Common cysK cysteine synthase A NIS_1469 220 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 152989974 Common rplW 50S ribosomal protein L23 NIS_0225 118 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 152990922 Common glyA glycine hydroxymethyltransferase NIS_1178 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 152990720 Common - hydrogenase expression/formation protein HupF/HypC NIS_0975 87 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 152990975 Common proB glutamate 5-kinase NIS_1231 190 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 152991087 Nonpathogen - hypothetical protein NIS_1344 3 None None None 152991294 Common fdhF formate dehydrogenase, alpha subunit NIS_1552 184 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 152990053 Common ubiA 4-hydroxybenzoate polyprenyltransferase NIS_0304 161 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 152991101 Common - hypothetical protein NIS_1358 81 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 152990077 Common ppk polyphosphate kinase NIS_0328 161 COG0855 Ppk, Polyphosphate kinase Inorganic ion transport and metabolism 152990852 Common truA tRNA pseudouridine synthase A NIS_1108 231 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 152990631 Common - hypothetical protein NIS_0884 37 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 152990605 Common - potassium channel protein NIS_0858 58 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 152990048 Common nuoK NADH-quinone oxidoreductase, chain K NIS_0299 69 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 152990729 Common - flagellar motor protein MotB NIS_0984 133 COG1360 MotB, Flagellar motor protein Cell motility and secretion 152990233 Common - hypothetical protein NIS_0484 60 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 152990358 Common - flagellar basal-body rod protein FlgF NIS_0609 121 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 152990333 Common pstC phosphate ABC transporter, permease NIS_0584 226 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 152991118 Nonpathogen - hypothetical protein NIS_1375 2 None None None 152990785 Common thrC threonine synthase NIS_1040 131 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 152990741 Common oppC oligopeptide ABC transporter, permease NIS_0996 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 152991020 Common - Na+:H+ antiporter NIS_1277 99 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 152991111 Common - hypothetical protein NIS_1368 178 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 152991185 Common - glycosyl transferase NIS_1443 219 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152990597 Common - hypothetical protein NIS_0850 150 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 152991515 Nonpathogen - hypothetical protein NIS_1775 3 None None None 152990845 Common cysS cysteinyl-tRNA synthetase NIS_1101 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152990056 Common - hypothetical protein NIS_0307 6 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 152990424 Common - HAD-superfamily hydrolase NIS_0675 96 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 152990294 Common carB carbamoylphosphate synthase, large subunit NIS_0545 237 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 152990802 Common - DNA repair protein RadA/Sms NIS_1057 201 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 152990762 Common sufC Fe-S cluster assembly ATPase SufC NIS_1017 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 152991376 Common - molybdenum cofactor biosynthesis protein E NIS_1635 19 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 152991246 Common rpsP 30S ribosomal protein S16 NIS_1504 213 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 152990884 Common - aspartate kinase, monofunctional class NIS_1140 237 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 152989832 Common - thioredoxin NIS_0080 29 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 152990271 Common - DNA polymerase III, epsilon subunit NIS_0522 79 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 152990117 Common - carbonate dehydratase NIS_0368 52 COG3338 Cah, Carbonic anhydrase Inorganic ion transport and metabolism 152990093 Common - magnesium transporter NIS_0344 173 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 152991080 Common purD phosphoribosylamine--glycine ligase NIS_1337 233 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 152991107 Common kdsA 3-deoxy-8-phosphooctulonate synthase NIS_1364 186 COG2877 KdsA, 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase Cell envelope biogenesis, outer membrane 152991049 Common - hypothetical protein NIS_1306 119 COG1801 COG1801, Uncharacterized conserved protein Function unknown 152990317 Common - inorganic phosphate transporter, PiT family NIS_0568 145 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 152990142 Common metK S-adenosylmethionine synthetase NIS_0393 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 152989957 Nonpathogen - hypothetical protein NIS_0208 2 COG5502 COG5502, Uncharacterized conserved protein Function unknown 152991593 Common - hypothetical protein NIS_1854 21 COG4636 Uma2, Uncharacterized protein conserved in cyanobacteria Function unknown 152989950 Common - hypothetical protein NIS_0201 117 COG0729 COG0729, Outer membrane protein Cell envelope biogenesis, outer membrane 152991180 Common - hypothetical protein NIS_1438 19 None None None 152989979 Common rplP 50S ribosomal protein L16 NIS_0230 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 152991583 Common - orotate phosphoribosyltransferase NIS_1844 94 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 152989874 Common - hypothetical protein NIS_0124 9 COG3213 NnrS, Uncharacterized protein involved in response to NO Inorganic ion transport and metabolism 152989938 Common - hypothetical protein NIS_0189 3 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 152989785 Common - sulfur oxidation protein, flavocytochrome c NIS_0032 61 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 152990868 Common rpsO 30S ribosomal protein S15 NIS_1124 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 152990490 Common - UDP-glucose 6-dehydrogenase NIS_0741 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 152989856 Common prfA peptide chain release factor 1 NIS_0104 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 152990374 Common - hypothetical protein NIS_0625 2 None None None 152990614 Common - signal transduction response regulator NIS_0867 179 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152991062 Common - hypothetical protein NIS_1319 164 COG1179 COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Coenzyme metabolism 152989811 Common hisF imidazoleglycerol phosphate synthase, cyclase subunit NIS_0059 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 152990262 Nonpathogen - hypothetical protein NIS_0513 1 None None None 152990919 Common - twitching motility protein PilT NIS_1175 224 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 152989763 Common - succinate dehydrogenase/fumarate reductase, iron-sulfur protein NIS_0010 204 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 152991076 Common pnp polyribonucleotide nucleotidyltransferase NIS_1333 238 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 152990285 Common - long-chain fatty acid transport protein NIS_0536 60 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 152990470 Common hemL glutamate-1-semialdehyde 2,1-aminomutase NIS_0721 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 152990517 Nonpathogen - ferrous iron transport protein A NIS_0770 3 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 152991096 Common - hypothetical protein NIS_1353 4 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 152989818 Common - ATPase, AAA family NIS_0066 248 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 152989821 Common - hypothetical protein NIS_0069 181 COG1496 COG1496, Uncharacterized conserved protein Function unknown 152991044 Common - hypothetical protein NIS_1301 4 None None None 152990653 Nonpathogen - cytochrome c, class I NIS_0907 7 None None None 152991319 Common - hypothetical protein NIS_1577 4 None None None 152990070 Common trpF phosphoribosylanthranilate isomerase NIS_0321 201 COG0135 TrpF, Phosphoribosylanthranilate isomerase Amino acid transport and metabolism 152989882 Common - hypothetical protein NIS_0132 130 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152989918 Common - transcriptional regulator, LysR family NIS_0169 189 COG0583 LysR, Transcriptional regulator Transcription 152990575 Common acnB aconitate hydratase 2 NIS_0828 220 COG1049 AcnB, Aconitase B Energy production and conversion 152991448 Common - type I restriction-modification system, M subunit NIS_1707 161 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 152990346 Common mrp ATP-binding protein Mrp NIS_0597 229 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 152991354 Common - ferredoxin-like protein NIS_1613 81 COG0348 NapH, Polyferredoxin Energy production and conversion 152990467 Common - Ni-Fe hydrogenase, membrane subunit HycD/HyfD NIS_0718 54 COG0650 HyfC, Formate hydrogenlyase subunit 4 Energy production and conversion 152990686 Common - 4-alpha-glucanotransferase NIS_0940 13 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 152989774 Common - hypothetical protein NIS_0021 5 None None None 152990458 Common - peptidase M50 NIS_0709 80 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 152991356 Common ccoP cytochrome c oxidase, cbb3-type, subunit III NIS_1615 72 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 152990345 Common thiC thiamine biosynthesis protein ThiC NIS_0596 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 152990250 Common - hypothetical protein NIS_0501 15 COG4659 RnfG, Predicted NADH:ubiquinone oxidoreductase, subunit RnfG Energy production and conversion 152990565 Common hisS histidyl-tRNA synthetase NIS_0818 247 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152989942 Common - hypothetical protein NIS_0193 164 COG2319 COG2319, FOG: WD40 repeat General function prediction only 152989757 Common - hypothetical protein NIS_0004 151 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152990988 Common - transposase NIS_1245 155 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 152991100 Common - processing protease NIS_1357 164 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 152991380 Common - hypothetical protein NIS_1639 178 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152991395 Common - Na+:H+ antiporter NIS_1654 45 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 152990543 Common fbp fructose-1,6-bisphosphatase NIS_0796 108 COG0158 Fbp, Fructose-1,6-bisphosphatase Carbohydrate transport and metabolism 152990987 Common - hypothetical protein NIS_1243 9 None None None 152991301 Common rpmE 50S ribosomal protein L31 NIS_1559 165 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 152991488 Common - hypothetical protein NIS_1748 59 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 152990339 Common - von Willebrand factor type A domain protein NIS_0590 51 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 152989886 Common - hypothetical protein NIS_0136 186 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152990893 Common - voltage-gated chloride channel NIS_1149 140 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 152990798 Common - hypothetical protein NIS_1053 77 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 152991260 Common - histidinol-phosphatase, PHP family NIS_1518 40 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 152991360 Common - two-component response regulator NIS_1619 215 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152990302 Common - TonB-dependent receptor NIS_0553 127 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 152991209 Common - preprotein translocase subunit YajC NIS_1467 142 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 152990035 Common nfo endonuclease IV NIS_0286 106 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 152991232 Common tpiA triosephosphate isomerase NIS_1490 216 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 152989797 Common - ferredoxin-thioredoxin reductase, beta subunit NIS_0044 14 COG4802 FtrB, Ferredoxin-thioredoxin reductase, catalytic subunit Energy production and conversion 152990434 Common - thioesterase family protein NIS_0685 110 COG0824 FcbC, Predicted thioesterase General function prediction only 152991228 Common - oligopeptide ABC transporter, permease NIS_1486 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 152990993 Common - oligosaccharide transferase NIS_1250 9 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 152990438 Common - succinate dehydrogenase/fumarate reductase, iron-sulfur protein NIS_0689 209 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 152989806 Common - adenylosuccinate lyase NIS_0054 238 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 152990641 Nonpathogen - hypothetical protein NIS_0894 1 None None None 152990917 Common - hypothetical protein NIS_1173 7 COG2976 COG2976, Uncharacterized protein conserved in bacteria Function unknown 152990758 Common valS valyl-tRNA synthetase NIS_1013 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152990807 Common - hypothetical protein NIS_1062 114 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 152991501 Common - ATPase, RecA-superfamily NIS_1761 33 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 152991587 Common - hypothetical protein NIS_1848 14 COG1654 BirA, Biotin operon repressor Transcription 152991285 Common - hypothetical protein NIS_1543 61 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 152991580 Common - preprotein translocase subunit G NIS_1841 9 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 152990909 Common ssb single-strand DNA binding protein NIS_1165 213 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 152990742 Common - DNA methylase NIS_0997 19 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 152989847 Common feoB ferrous iron transport protein B NIS_0095 165 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 152990609 Common - hypothetical protein NIS_0862 150 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 152989986 Common rpsH 30S ribosomal protein S8 NIS_0237 243 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 152990791 Common - hypothetical protein NIS_1046 192 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 152991532 Common - heme d1 biosynthesis protein NirJ NIS_1792 160 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 152990474 Common - hypothetical protein NIS_0725 90 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 152991197 Common rho transcription termination factor Rho NIS_1455 223 COG1158 Rho, Transcription termination factor Transcription 152990321 Nonpathogen - hypothetical protein NIS_0572 14 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 152991359 Common ccoN cytochrome c oxidase, cbb3-type, subunit I NIS_1618 134 COG3278 CcoN, Cbb3-type cytochrome oxidase, subunit 1 Posttranslational modification, protein turnover, chaperones 152989858 Common glmM phosphoglucosamine mutase NIS_0106 243 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 152989981 Common rpsQ 30S ribosomal protein S17 NIS_0232 221 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 152990105 Common - hypothetical protein NIS_0356 7 None None None 152990225 Common - hypothetical protein NIS_0476 15 COG3941 COG3941, Mu-like prophage protein General function prediction only 152990602 Common - hypothetical protein NIS_0855 86 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 152991509 Common - hypothetical protein NIS_1769 69 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 152989878 Common - D-isomer specific 2-hydroxyacid dehydrogenase, catalytic component NIS_0128 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 152990030 Common - hypothetical protein NIS_0281 118 None None None 152991432 Common - site-specific recombinase, phage integrase family NIS_1691 165 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 152990880 Common - hypothetical protein NIS_1136 132 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 152990746 Common hslU ATP-dependent protease HslVU, ATPase subunit HslU NIS_1001 210 COG1220 HslU, ATP-dependent protease HslVU (ClpYQ), ATPase subunit Posttranslational modification, protein turnover, chaperones 152990015 Common rplJ 50S ribosomal protein L10 NIS_0266 214 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 152991539 Common - hypothetical protein NIS_1799 3 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 152989926 Common - neurotransmitter:Na+ symporter, NSS family NIS_0177 88 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 152989871 Nonpathogen - hypothetical protein NIS_0121 1 None None None 152991454 Common - serine protease Do NIS_1713 225 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 152990827 Common aroB 3-dehydroquinate synthase NIS_1083 213 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 152991158 Common - NAD-dependent epimerase/dehydratase NIS_1416 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152990154 Common - hypothetical protein NIS_0405 18 None None None 152991038 Common - saccharopine dehydrogenase (NAD+, L-lysine forming) NIS_1295 55 COG1748 LYS9, Saccharopine dehydrogenase and related proteins Amino acid transport and metabolism 152991192 Common - D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase NIS_1450 132 COG0241 HisB, Histidinol phosphatase and related phosphatases Amino acid transport and metabolism 152991524 Common - hypothetical protein NIS_1784 26 COG2863 COG2863, Cytochrome c553 Energy production and conversion 152991325 Common - ubiquinol cytochrome c oxidoreductase, cytochrome c1 subunit NIS_1583 18 COG2857 CYT1, Cytochrome c1 Energy production and conversion 152990972 Common - biotin-[acetyl-CoA-carboxylase] ligase NIS_1228 93 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 152990695 Nonpathogen - hypothetical protein NIS_0950 2 COG3295 COG3295, Uncharacterized protein conserved in bacteria Function unknown 152991056 Common greA transcription elongation factor GreA NIS_1313 204 COG0782 GreA, Transcription elongation factor Transcription 152990570 Common minD cell division inhibitor MinD NIS_0823 133 COG2894 MinD, Septum formation inhibitor-activating ATPase Cell division and chromosome partitioning 152990735 Common - hypothetical protein NIS_0990 81 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 152991239 Common gmk guanylate kinase NIS_1497 213 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 152990958 Common - peptidoglycan-associated lipoprotein NIS_1214 146 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 152991553 Common - hypothetical protein NIS_1813 4 None None None 152990326 Common - hypothetical protein NIS_0577 15 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 152990834 Common - hypothetical protein NIS_1090 42 COG1694 MazG, Predicted pyrophosphatase General function prediction only 152990832 Common - hypothetical protein NIS_1088 57 COG0011 COG0011, Uncharacterized conserved protein Function unknown 152990245 Common - hypothetical protein NIS_0496 10 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 152990843 Common - hypothetical protein NIS_1099 30 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 152990839 Common - hypothetical protein NIS_1095 133 COG2860 COG2860, Predicted membrane protein Function unknown 152990687 Common - glycoside hydrolase NIS_0941 35 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 152990169 Common thrB homoserine kinase NIS_0420 121 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 152989941 Common - protein phosphatase NIS_0192 58 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 152990167 Common - UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase NIS_0418 139 COG0774 LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase Cell envelope biogenesis, outer membrane 152990389 Common - flagellin NIS_0640 110 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 152990889 Common tatC twin-arginine translocation system component TatC NIS_1145 205 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 152990927 Common - hypothetical protein NIS_1183 126 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152991334 Common - sulfonate/nitrate ABC transporter, ATP-binding protein NIS_1593 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 152990776 Common - hypothetical protein NIS_1031 119 None None None 152990119 Common lgt prolipoprotein diacylglyceryl transferase NIS_0370 207 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 152989914 Common tig trigger factor NIS_0164 219 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 152991322 Common - 6-pyruvoyl-tetrahydropterin synthase NIS_1580 18 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 152991009 Common murC UDP-N-acetylmuramate-alanine ligase NIS_1266 208 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 152991498 Common - hypothetical protein NIS_1758 189 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152990455 Common trpB tryptophan synthase, beta chain NIS_0706 224 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 152990876 Common - hemolysin A NIS_1132 133 COG1189 COG1189, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 152991035 Common - cytochrome c, class I NIS_1292 17 COG2863 COG2863, Cytochrome c553 Energy production and conversion 152990273 Common - solute:sodium symporter NIS_0524 177 COG4147 DhlC, Predicted symporter General function prediction only 152991166 Common - biopolymer transport protein, ExbB/TolQ family NIS_1424 57 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 152990502 Common ftsE cell division ATP-binding protein FtsE NIS_0755 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 152990933 Nonpathogen - hypothetical protein NIS_1189 1 None None None 152990236 Common - hypothetical protein NIS_0487 28 COG2862 COG2862, Predicted membrane protein Function unknown 152990197 Nonpathogen - hypothetical protein NIS_0448 1 None None None 152990379 Common - flagellar motor switch protein FliN/FliY NIS_0630 113 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 152990714 Common - hydrogenase maturation protein HypF NIS_0969 110 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 152991349 Common - rhodanese family protein NIS_1608 42 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152990447 Common - 7-alpha-hydroxysteroid dehydrogenase NIS_0698 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152990697 Common - ferredoxin--nitrite reductase NIS_0952 139 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 152989969 Common - hypothetical protein NIS_0220 27 COG3744 COG3744, Uncharacterized protein conserved in bacteria Function unknown 152991416 Common - hypothetical protein NIS_1675 120 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 152990678 Common - pyruvate/2-oxoglutarate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase NIS_0932 196 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 152991371 Common - Ham1 family protein NIS_1630 232 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 152991561 Nonpathogen - hypothetical protein NIS_1822 3 None None None 152991308 Common - general secretory pathway protein D NIS_1566 142 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 152989902 Nonpathogen - hypothetical protein NIS_0152 2 None None None 152990427 Common dnaE DNA polymerase III, alpha subunit NIS_0678 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 152990652 Common - hypothetical protein NIS_0906 116 COG0701 COG0701, Predicted permeases General function prediction only 152991135 Common - hypothetical protein NIS_1393 125 None None None 152989851 Common purM phosphoribosylformylglycinamidine cyclo-ligase NIS_0099 232 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 152990509 Common - 2-nitropropane dioxygenase NIS_0762 137 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 152991404 Common - O-sialoglycoprotein endopeptidase NIS_1663 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 152991271 Common - cell division protein FtsI NIS_1529 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 152990539 Common - calcium:H+/Na+ antiporter, CaCA family NIS_0792 60 COG0387 ChaA, Ca2+/H+ antiporter Inorganic ion transport and metabolism 152991469 Nonpathogen - hypothetical protein NIS_1728 1 None None None 152990136 Common - diaminopimelate decarboxylase NIS_0387 219 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 152989817 Common - hypothetical protein NIS_0065 138 COG0432 COG0432, Uncharacterized conserved protein Function unknown 152989869 Common sufE Fe-S cluster assembly protein SufE NIS_0119 90 COG2166 COG2166, SufE protein probably involved in Fe-S center assembly General function prediction only 152991033 Common - hypothetical protein NIS_1290 2 None None None 152991253 Common glyQ glycyl-tRNA synthetase, alpha subunit NIS_1511 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 152990951 Common - hypothetical protein NIS_1207 4 None None None 152991278 Common tsf translation elongation factor Ts NIS_1536 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 152990708 Common - Ni-Fe hydrogenase, small subunit NIS_0963 77 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 152990547 Common - hypothetical protein NIS_0800 110 COG0762 COG0762, Predicted integral membrane protein Function unknown 152990659 Common - two-component sensor histidine kinase NIS_0913 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152991543 Common - periplasmic nitrate reductase component NapL NIS_1803 8 COG2319 COG2319, FOG: WD40 repeat General function prediction only 152989784 Common nhaA Na+:H+ antiporter, NhaA family NIS_0031 106 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 152990292 Common mreB cell shape-determining protein MreB NIS_0543 236 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 152990311 Common fbaA fructose-bisphosphate aldolase, class II NIS_0562 174 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 152990771 Common - hypothetical protein NIS_1026 7 None None None 152991378 Common - hypothetical protein NIS_1637 11 COG1427 COG1427, Predicted periplasmic solute-binding protein General function prediction only 152990422 Nonpathogen - hypothetical protein NIS_0673 2 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 152990904 Common - hypothetical protein NIS_1160 57 COG2861 COG2861, Uncharacterized protein conserved in bacteria Function unknown 152990786 Common cutA divalent cation tolerance protein NIS_1041 114 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 152991297 Common - hypothetical protein NIS_1555 6 None None None 152991333 Common - sulfonate/nitrate ABC transporter, permease NIS_1592 144 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 152989759 Common - succinate dehydrogenase/fumarate reductase, flavoprotein subunit NIS_0006 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 152990115 Common - ATP-dependent DNA helicase, UvrD/REP family NIS_0366 219 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 152991047 Nonpathogen - Na+-transporting oxaloacetate decarboxylase, gamma subunit NIS_1304 4 COG3630 OadG, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, gamma subunit Energy production and conversion 152989955 Common - A/G-specific adenine glycosylase NIS_0206 235 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 152990253 Common - thiamine biosynthesis lipoprotein NIS_0504 123 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 152990140 Common dxs 1-deoxy-D-xylulose 5-phosphate synthase NIS_0391 212 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 152990858 Common allB dihydroorotase NIS_1114 207 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 152990764 Common - metal-sulfur cluster biosynthetic enzyme NIS_1019 141 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 152991082 Common guaA GMP synthase (glutamine-hydrolyzing) NIS_1339 241 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 152990850 Common - type 4 prepilin peptidase NIS_1106 125 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 152990310 Common - peptidyl-prolyl cis-trans isomerase NIS_0561 160 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 152991510 Common - hypothetical protein NIS_1770 22 None None None 152990760 Common - dUTP diphosphatase NIS_1015 11 COG4508 COG4508, Uncharacterized protein conserved in bacteria Function unknown 152990920 Common - colicin V production protein NIS_1176 11 COG1286 CvpA, Uncharacterized membrane protein, required for colicin V production General function prediction only 152991064 Nonpathogen - hypothetical protein NIS_1321 1 None None None 152991103 Common nusB transcription antitermination factor NusB NIS_1360 201 COG0781 NusB, Transcription termination factor Transcription 152989792 Common - hypothetical protein NIS_0039 52 None None None 152991089 Common - two-component sensor histidine kinase/response regulator NIS_1346 226 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152991138 Common - hypothetical protein NIS_1396 32 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 152991149 Common leuA 2-isopropylmalate synthase NIS_1407 217 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 152989876 Common ilvD dihydroxy-acid dehydratase NIS_0126 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 152989761 Common - circadian clock protein KaiC NIS_0008 65 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 152990948 Common - methyl-accepting chemotaxis protein NIS_1204 162 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152991213 Common - hypothetical protein NIS_1471 7 None None None 152990075 Common - sulfide-quinone reductase NIS_0326 59 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 152991344 Common - pyruvate:ferredoxin oxidoreductase, alpha subunit NIS_1603 120 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 152991424 Nonpathogen - hypothetical protein NIS_1683 1 None None None 152989931 Nonpathogen - hypothetical protein NIS_0182 1 None None None 152991176 Common - molybdopterin oxidoreductase, iron sulfur subunit NIS_1434 160 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 152990599 Common - hypothetical protein NIS_0852 22 None None None 152989972 Common rplC 50S ribosomal protein L3 NIS_0223 216 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 152991177 Common - nitrate reductase catalytic subunit NIS_1435 191 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 152990051 Common nuoN NADH-quinone oxidoreductase, chain N NIS_0302 210 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 152991094 Common - hypothetical protein NIS_1351 5 None None None 152989835 Nonpathogen - hypothetical protein NIS_0083 9 COG0730 COG0730, Predicted permeases General function prediction only 152990138 Common pheA chorismate mutase/prephenate dehydratase NIS_0389 214 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 152991459 Common - patatin NIS_1718 119 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 152991029 Common - NUDIX hydrolase NIS_1286 109 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 152990668 Common - RNA-metabolising metallo-beta-lactamase NIS_0922 125 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 152990335 Common pstB phosphate ABC transporter, ATP-binding protein NIS_0586 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 152990595 Common - RNA-binding S4 protein NIS_0848 32 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 152990603 Common - glutamyl-tRNA amidotransferase subunit B NIS_0856 214 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 152990131 Common tal transaldolase NIS_0382 136 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 152991273 Common murG undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase NIS_1531 203 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 152990356 Common fliM flagellar motor switch protein FliM NIS_0607 104 COG1868 FliM, Flagellar motor switch protein Cell motility and secretion 152990878 Common - hypothetical protein NIS_1134 163 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152990512 Common - hypothetical protein NIS_0765 3 None None None 152990003 Common - 2Fe-2S ferredoxin NIS_0254 69 COG3411 COG3411, Ferredoxin Energy production and conversion 152990577 Common secA preprotein translocase subunit A NIS_0830 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 152991573 Common - two-component response regulator NIS_1834 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152989990 Common rplO 50S ribosomal protein L15 NIS_0241 216 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 152990460 Common folD 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase NIS_0711 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 152991517 Common - hypothetical protein NIS_1777 144 COG1648 CysG, Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) Coenzyme metabolism 152991352 Common - hypothetical protein NIS_1611 7 COG3198 COG3198, Uncharacterized protein conserved in bacteria Function unknown 152990739 Common - hypothetical protein NIS_0994 2 None None None 152991010 Common - hypothetical protein NIS_1267 4 None None None 152990983 Nonpathogen - hypothetical protein NIS_1239 4 None None None 152991387 Common dcd deoxycytidine triphosphate deaminase NIS_1646 145 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 152991170 Common - phosphomannomutase NIS_1428 238 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 152990280 Common - hypothetical protein NIS_0531 6 None None None 152989772 Common - molybdenum ABC transporter, permease NIS_0019 203 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 152991382 Common gltX glutamyl-tRNA synthetase NIS_1641 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 152990523 Common - hypothetical protein NIS_0776 137 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 152990174 Common ubiE ubiquinone/menaquinone biosynthesis methyltransferase NIS_0425 212 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152989828 Common - efflux transporter, RND superfamily NIS_0076 180 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 152989928 Common - hypothetical protein NIS_0179 29 None None None 152990985 Common - thioredoxin NIS_1241 15 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 152990870 Common - transcriptional regulator, BadM/Rrf2 family NIS_1126 156 COG1959 COG1959, Predicted transcriptional regulator Transcription 152989944 Common - mannose-1-phosphate guanylyltransferase NIS_0195 164 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 152990383 Common fliR flagellar biosynthetic protein FliR NIS_0634 124 COG1684 FliR, Flagellar biosynthesis pathway, component FliR Cell motility and secretion / Intracellular trafficking and secretion 152989787 Nonpathogen - sulfur oxidation protein SoxY NIS_0034 22 COG5501 COG5501, Predicted secreted protein Function unknown 152990084 Common - hypothetical protein NIS_0335 3 None None None 152991202 Common - fumarylacetoacetate hydrolase family protein NIS_1460 172 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 152989895 Common - hypothetical protein NIS_0145 7 COG1433 COG1433, Uncharacterized conserved protein Function unknown 152990979 Common - translation initiation inhibitor NIS_1235 190 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 152990126 Nonpathogen - hypothetical protein NIS_0377 1 COG3134 COG3134, Predicted outer membrane lipoprotein Function unknown 152990649 Common - heavy metal efflux pump, CzcB family NIS_0903 89 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 152991292 Common trxA thioredoxin NIS_1550 236 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 152990091 Common - hypothetical protein NIS_0342 7 None None None 152990935 Common uvrA excinuclease ABC, A subunit NIS_1191 241 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 152990364 Common flhA flagellar biosynthesis protein FlhA NIS_0615 127 COG1298 FlhA, Flagellar biosynthesis pathway, component FlhA Cell motility and secretion / Intracellular trafficking and secretion 152989848 Common - nitrous oxidase accessory protein NosD NIS_0096 50 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 152991470 Common - hypothetical protein NIS_1729 9 None None None 152990224 Nonpathogen - hypothetical protein NIS_0475 1 None None None 152991477 Nonpathogen - hypothetical protein NIS_1736 2 None None None 152990472 Common - hypothetical protein NIS_0723 5 None None None 152990499 Common - ribosomal large subunit pseudouridine synthase D NIS_0752 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 152989823 Common - phosphoribosyltransferase NIS_0071 74 COG1926 COG1926, Predicted phosphoribosyltransferases General function prediction only 152990264 Common - transcriptional regulator, Sir2 family NIS_0515 145 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 152990028 Common - DNA polymerase IV NIS_0279 183 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 152990528 Common - GTP-binding protein NIS_0781 177 COG0218 COG0218, Predicted GTPase General function prediction only 152991074 Nonpathogen - prevent-host-death family protein NIS_1331 4 None None None 152990567 Common coaD phosphopantetheine adenylyltransferase NIS_0820 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 152991254 Common - glutaredoxin NIS_1512 35 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 152991123 Common - mannose-1-phosphate guanylyltransferase NIS_1380 164 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 152990185 Common lepA GTP-binding protein LepA NIS_0436 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 152989916 Common def formylmethionine deformylase NIS_0166 214 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis