Sinorhizobium medicae WSM419 plasmid pSMED02, complete sequence NC_009621 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 150377246 Nonpathogen - hypothetical protein Smed_5131 2 None None None 150378080 Common - thiamineS protein Smed_6103 27 None None None 150377992 Common - flavin reductase domain protein FMN-binding Smed_5977 121 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 150378127 Nonpathogen - hypothetical protein Smed_6165 1 None None None 150378105 Common - Transposase and inactivated derivatives-like protein Smed_6137 75 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377951 Common - hypothetical protein Smed_5921 37 COG5473 COG5473, Predicted integral membrane protein Function unknown 150377192 Common - putative transcriptional regulator, AsnC family Smed_5075 154 COG1522 Lrp, Transcriptional regulators Transcription 150377252 Common - Malonyl-CoA decarboxylase Smed_5137 29 None None None 150377482 Common - autoinducer synthesis protein Smed_5375 31 COG3916 LasI, N-acyl-L-homoserine lactone synthetase Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 150378014 Common - hypothetical protein Smed_6001 23 None None None 150377383 Nonpathogen - hypothetical protein Smed_5269 1 None None None 150378241 Nonpathogen - hypothetical protein Smed_6306 2 None None None 150378114 Nonpathogen - hypothetical protein Smed_6148 2 None None None 150378262 Common - NADH:flavin oxidoreductase/NADH oxidase Smed_6328 177 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 150377773 Common - Integrase catalytic region Smed_5714 108 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 150378152 Common - transposase IS66 Smed_6199 57 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377996 Nonpathogen - hypothetical protein Smed_5982 2 None None None 150377300 Nonpathogen - hypothetical protein Smed_5185 1 None None None 150377838 Common - amidohydrolase Smed_5797 153 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 150377873 Common - transcriptional regulator, GntR family Smed_5841 126 COG1802 GntR, Transcriptional regulators Transcription 150377836 Common - extracellular solute-binding protein family 5 Smed_5794 197 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 150377250 Common - Tripartite ATP-independent periplasmic transporter DctQ component Smed_5135 22 COG3090 DctM, TRAP-type C4-dicarboxylate transport system, small permease component Carbohydrate transport and metabolism 150378249 Common - spermidine/putrescine ABC transporter ATPase subunit Smed_6314 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 150377622 Nonpathogen - hypothetical protein Smed_5534 1 None None None 150377309 Common - amino acid permease-associated region Smed_5194 168 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 150377393 Nonpathogen - hypothetical protein Smed_5279 2 None None None 150377417 Nonpathogen - hypothetical protein Smed_5305 1 None None None 150377593 Nonpathogen - hypothetical protein Smed_5501 10 None None None 150377883 Common - transcriptional regulator, LysR family Smed_5851 127 COG0583 LysR, Transcriptional regulator Transcription 150377196 Common - binding-protein-dependent transport systems inner membrane component Smed_5079 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150378093 Common - hypothetical protein Smed_6119 3 None None None 150378077 Nonpathogen - hypothetical protein Smed_6100 1 None None None 150377341 Common - NADP oxidoreductase coenzyme F420-dependent Smed_5227 51 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 150377172 Common - arsenate reductase Smed_5055 110 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 150377845 Common - phage transcriptional regulator, AlpA Smed_5807 19 COG3311 AlpA, Predicted transcriptional regulator Transcription 150377956 Common - cytochrome c oxidase, cbb3-type, subunit I Smed_5926 136 COG3278 CcoN, Cbb3-type cytochrome oxidase, subunit 1 Posttranslational modification, protein turnover, chaperones 150378064 Common - acyl carrier protein Smed_6081 190 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 150377619 Common - short-chain dehydrogenase/reductase SDR Smed_5531 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 150377927 Common - signal transduction histidine kinase Smed_5895 110 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 150378201 Common - Heavy metal transport/detoxification protein Smed_6264 51 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 150377489 Common - P-type conjugative transfer protein TrbL Smed_5382 36 COG3846 TrbL, Type IV secretory pathway, TrbL components Intracellular trafficking and secretion 150377757 Nonpathogen - hypothetical protein Smed_5694 1 None None None 150377401 Common - Serralysin Smed_5287 95 COG2931 COG2931, RTX toxins and related Ca2+-binding proteins Secondary metabolites biosynthesis, transport, and catabolism 150377653 Nonpathogen - hypothetical protein Smed_5567 6 None None None 150378257 Common - histidine kinase Smed_6322 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 150377713 Common - integral membrane sensor signal transduction histidine kinase Smed_5634 223 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 150378147 Common - Beta-ketoacyl synthase Smed_6194 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 150377786 Nonpathogen - hypothetical protein Smed_5732 1 None None None 150378235 Common - hypothetical protein Smed_6300 2 None None None 150378208 Common - transposase IS111A/IS1328/IS1533 Smed_6272 56 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377688 Common - GCN5-related N-acetyltransferase Smed_5606 21 COG2153 ElaA, Predicted acyltransferase General function prediction only 150377291 Nonpathogen - protein of unknown function DUF1127 Smed_5176 1 COG5457 COG5457, Uncharacterized conserved small protein Function unknown 150377216 Common - Malate/L-lactate dehydrogenase Smed_5101 64 COG2055 COG2055, Malate/L-lactate dehydrogenases Energy production and conversion 150377453 Common - ABC transporter related Smed_5343 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 150377498 Common - Peptidase S26C conjugative transfer signal peptidase TraF Smed_5392 32 COG4959 TraF, Type IV secretory pathway, protease TraF Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 150377931 Common - protein of unknown function DUF395 YeeE/YedE Smed_5899 51 COG2391 COG2391, Predicted transporter component General function prediction only 150377352 Common - helix-turn-helix- domain containing protein AraC type Smed_5238 64 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 150377847 Common - putative LysR-family transcriptional regulator Smed_5812 32 None None None 150377265 Common - Activator of Hsp90 ATPase 1 family protein Smed_5150 40 COG3832 COG3832, Uncharacterized conserved protein Function unknown 150377828 Common - hypothetical protein Smed_5786 88 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 150378159 Common - transposase IS116/IS110/IS902 family protein Smed_6214 90 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 150378224 Common - Nitric-oxide reductase Smed_6288 117 COG3256 NorB, Nitric oxide reductase large subunit Inorganic ion transport and metabolism 150377584 Nonpathogen - Formate dehydrogenase region TAT target Smed_5492 3 None None None 150377288 Common - Cobyrinic acid ac-diamide synthase Smed_5173 202 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 150378140 Common - polysaccharide deacetylase Smed_6185 105 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 150377907 Common - inner-membrane translocator Smed_5875 107 COG4603 COG4603, ABC-type uncharacterized transport system, permease component General function prediction only 150377637 Nonpathogen - hypothetical protein Smed_5551 1 None None None 150377851 Common - transcriptional regulator, MarR family Smed_5817 99 COG1846 MarR, Transcriptional regulators Transcription 150377263 Common - major facilitator superfamily MFS_1 Smed_5148 125 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 150377898 Common - Mandelate racemase/muconate lactonizing protein Smed_5866 128 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 150377979 Common - two component, sigma54 specific, transcriptional regulator, Fis family Smed_5956 181 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 150377422 Common - oxidoreductase domain protein Smed_5310 203 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 150377493 Common - conjugation TrbI family protein Smed_5386 59 COG2948 VirB10, Type IV secretory pathway, VirB10 components Intracellular trafficking and secretion 150378134 Common - efflux transporter, RND family, MFP subunit Smed_6178 164 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 150377444 Common - inner-membrane translocator Smed_5334 115 COG1079 COG1079, Uncharacterized ABC-type transport system, permease component General function prediction only 150377815 Nonpathogen - hypothetical protein Smed_5771 3 None None None 150377186 Nonpathogen - hypothetical protein Smed_5069 1 None None None 150377865 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase Smed_5832 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 150377346 Common - amidohydrolase Smed_5232 81 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 150377871 Common - GntR domain protein Smed_5838 104 COG2186 FadR, Transcriptional regulators Transcription 150377630 Common - ThiJ/PfpI domain protein Smed_5542 115 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 150378182 Common - succinic semialdehyde dehydrogenase Smed_6245 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 150377601 Common - putative fimbrial chaperone protein Smed_5510 24 COG3121 FimC, P pilus assembly protein, chaperone PapD Cell motility and secretion / Intracellular trafficking and secretion 150377224 Common - transcriptional regulator, AraC family Smed_5109 151 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 150377541 Nonpathogen - hypothetical protein Smed_5441 2 COG3857 AddB, ATP-dependent nuclease, subunit B DNA replication, recombination, and repair 150378199 Nonpathogen - hypothetical protein Smed_6262 1 None None None 150377177 Common - Hemolysin-type calcium-binding region Smed_5060 80 None None None 150378179 Common - Integrase catalytic region Smed_6240 110 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 150378189 Common - luciferase family protein Smed_6252 114 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 150378024 Common - transposase IS3/IS911 family protein Smed_6020 60 None None None 150377538 Common - hypothetical protein Smed_5438 8 None None None 150378237 Common - hypothetical protein Smed_6302 5 None None None 150377569 Common - binding-protein-dependent transport systems inner membrane component Smed_5471 195 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 150377546 Common - hypothetical protein Smed_5446 10 None None None 150377533 Common - PilT protein domain protein Smed_5432 17 COG3742 COG3742, Uncharacterized protein conserved in bacteria Function unknown 150377515 Common - conserved putative protein Smed_5412 44 COG2843 PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) Cell envelope biogenesis, outer membrane 150378192 Common - protein of unknown function DUF1185 Smed_6255 23 None None None 150378035 Common - hypothetical protein Smed_6036 22 COG5591 COG5591, Uncharacterized conserved protein Function unknown 150378066 Common groEL chaperonin GroEL Smed_6084 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 150378008 Nonpathogen - hypothetical protein Smed_5995 1 None None None 150378061 Nonpathogen - hypothetical protein Smed_6077 1 None None None 150377942 Common - HAD-superfamily hydrolase, subfamily IIB Smed_5910 89 COG1877 OtsB, Trehalose-6-phosphatase Carbohydrate transport and metabolism 150378213 Common - protein of unknown function DUF323 Smed_6277 37 COG1262 COG1262, Uncharacterized conserved protein Function unknown 150378161 Common - Ferredoxin III 4(4Fe-4S) nif-specific Smed_6219 27 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 150377919 Common - Monosaccharide-transporting ATPase Smed_5887 97 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 150377437 Common - transcriptional regulator, TetR family Smed_5327 64 COG1309 AcrR, Transcriptional regulator Transcription 150377627 Common - protein of unknown function DUF1228 Smed_5539 74 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 150377388 Common - transcriptional regulator, LysR family Smed_5274 175 COG0583 LysR, Transcriptional regulator Transcription 150377379 Common - putative ABC transporter, periplasmic solute-binding protein Smed_5265 87 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 150377665 Common - binding-protein-dependent transport systems inner membrane component Smed_5581 150 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 150377881 Common - hypothetical protein Smed_5849 20 COG5552 COG5552, Uncharacterized conserved protein Function unknown 150377912 Common - FAD dependent oxidoreductase Smed_5880 82 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 150377361 Common - nitric oxide dioxygenase Smed_5247 140 COG1017 Hmp, Hemoglobin-like flavoprotein Energy production and conversion 150377743 Common - hypothetical protein Smed_5676 3 None None None 150377733 Common - Ion transport 2 domain protein Smed_5664 29 None None None 150377324 Common - cellulose synthase subunit B Smed_5209 8 None None None 150377471 Common - two component transcriptional regulator, winged helix family Smed_5362 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 150377671 Common - FAD dependent oxidoreductase Smed_5589 83 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 150377778 Common - Epoxide hydrolase domain protein Smed_5719 35 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 150377888 Common - hypothetical protein Smed_5856 29 COG5441 COG5441, Uncharacterized conserved protein Function unknown 150377858 Common - alpha/beta hydrolase fold Smed_5825 153 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 150378072 Common - transposase IS66 Smed_6094 58 None None None 150378095 Common - transposase IS3/IS911 family protein Smed_6122 19 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377587 Nonpathogen - molybdopterin-guanine dinucleotide biosynthesis protein A Smed_5495 9 None None None 150377642 Nonpathogen - protein of unknown function DUF187 Smed_5556 9 COG1649 COG1649, Uncharacterized protein conserved in bacteria Function unknown 150377463 Common - DNA polymerase IV Smed_5353 185 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 150377649 Common - hypothetical protein Smed_5563 2 None None None 150378101 Common - hypothetical protein Smed_6130 5 None None None 150378040 Common - flavin reductase domain protein FMN-binding Smed_6044 121 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 150377791 Common - helix-turn-helix- domain containing protein AraC type Smed_5741 119 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 150377969 Common - feruloyl esterase Smed_5940 51 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377696 Common - putative (L31491) ORF2; putative (plasmid pTOM9) Smed_5615 12 None None None 150377573 Common - L-lactate dehydrogenase (cytochrome) Smed_5475 110 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 150378174 Common - nitrogenase cofactor biosynthesis protein NifB Smed_6233 66 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 150377804 Nonpathogen - response regulator receiver protein Smed_5755 1 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 150377862 Common - transcriptional regulator, LysR family Smed_5829 115 COG0583 LysR, Transcriptional regulator Transcription 150377238 Common - Flp/Fap pilin component Smed_5123 33 COG3847 Flp, Flp pilus assembly protein, pilin Flp Intracellular trafficking and secretion 150377501 Common - Conjugal transfer TraD family protein Smed_5395 12 None None None 150377745 Common - transcriptional regulator, XRE family Smed_5678 18 COG1476 COG1476, Predicted transcriptional regulators Transcription 150377391 Common - adenine deaminase Smed_5277 85 COG1001 AdeC, Adenine deaminase Nucleotide transport and metabolism 150378070 Nonpathogen - hypothetical protein Smed_6090 1 None None None 150377293 Common - ferredoxin-type protein NapF Smed_5178 96 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 150377467 Common - potassium-transporting ATPase subunit A Smed_5358 96 COG2060 KdpA, K+-transporting ATPase, A chain Inorganic ion transport and metabolism 150378026 Nonpathogen - hypothetical protein Smed_6022 1 None None None 150377231 Common - putative CheW protein Smed_5116 27 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 150377663 Common - ABC transporter related Smed_5579 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 150377433 Common - two component transcriptional regulator, LuxR family Smed_5322 138 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 150377595 Common - binding-protein-dependent transport systems inner membrane component Smed_5503 69 COG4662 TupA, ABC-type tungstate transport system, periplasmic component Coenzyme metabolism 150377211 Common - acetyl-CoA acetyltransferase Smed_5096 173 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 150377221 Common - binding-protein-dependent transport systems inner membrane component Smed_5106 163 COG1174 OpuBB, ABC-type proline/glycine betaine transport systems, permease component Amino acid transport and metabolism 150377576 Common - plasmid maintenance system killer Smed_5480 60 COG3549 HigB, Plasmid maintenance system killer protein General function prediction only 150377410 Nonpathogen - hypothetical protein Smed_5298 1 None None None 150377894 Common - ABC transporter related Smed_5862 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 150377198 Common - 5-dehydro-4-deoxyglucarate dehydratase Smed_5081 218 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 150377771 Common - NmrA family protein Smed_5710 27 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 150378170 Common - Electron transfer flavoprotein alpha/beta-subunit Smed_6229 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 150377194 Common - ABC transporter related Smed_5077 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 150377860 Common - helix-turn-helix- domain containing protein AraC type Smed_5827 96 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 150378107 Common - Pectate lyase Smed_6139 21 COG3866 PelB, Pectate lyase Carbohydrate transport and metabolism 150377307 Common - calcium/proton antiporter, CaCA family Smed_5192 44 COG0387 ChaA, Ca2+/H+ antiporter Inorganic ion transport and metabolism 150377784 Common - transcriptional regulator domain protein Smed_5729 80 COG5616 COG5616, Predicted integral membrane protein Function unknown 150377209 Common - 3-oxoacid CoA-transferase, B subunit Smed_5093 95 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 150377259 Common - peptidase S8 and S53 subtilisin kexin sedolisin Smed_5144 121 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 150377446 Common - ABC transporter related Smed_5336 249 COG3845 COG3845, ABC-type uncharacterized transport systems, ATPase components General function prediction only 150377964 Common - cytochrome c oxidase, cbb3-type, subunit II Smed_5934 82 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 150378016 Common - glutamine synthetase catalytic region Smed_6005 223 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 150377381 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Smed_5267 57 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 150377974 Common - virulence factor family protein Smed_5950 19 COG3946 VirJ, Type IV secretory pathway, VirJ component Intracellular trafficking and secretion 150377218 Common - Substrate-binding region of ABC-type glycine betaine transport system Smed_5103 90 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 150377686 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Smed_5604 226 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 150377348 Common - protein of unknown function UPF0118 Smed_5234 158 COG0628 PerM, Predicted permease General function prediction only 150378243 Common - transcriptional regulator, GntR family Smed_6308 123 COG2188 PhnF, Transcriptional regulators Transcription 150377496 Common - putative transcriptional regulator, XRE family Smed_5389 26 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 150377875 Common - short-chain dehydrogenase/reductase SDR Smed_5843 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 150377905 Common - basic membrane lipoprotein Smed_5873 75 COG1744 Med, Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein General function prediction only 150377521 Nonpathogen - hypothetical protein Smed_5418 1 None None None 150378260 Common - putative L-sorbosone dehydrogenase Smed_6326 63 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 150377480 Common - 5-formyltetrahydrofolate cyclo-ligase Smed_5372 78 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 150378196 Common - hypothetical protein Smed_6259 79 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377555 Common - Alanine racemase Smed_5456 128 COG1609 PurR, Transcriptional regulators Transcription 150377802 Common - oxidoreductase domain protein Smed_5752 60 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 150377856 Common - MscS Mechanosensitive ion channel Smed_5823 98 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 150377267 Common - hypothetical protein Smed_5152 14 COG5482 COG5482, Uncharacterized conserved protein Function unknown 150378052 Nonpathogen - hypothetical protein Smed_6063 1 None None None 150377933 Common - UvrD/REP helicase Smed_5901 230 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 150377721 Common - monooxygenase FAD-binding Smed_5650 18 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 150377202 Common - methylmalonyl-CoA mutase, large subunit Smed_5086 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 150377896 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Smed_5864 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 150377711 Common - response regulator receiver protein Smed_5632 207 COG4566 TtrR, Response regulator Signal transduction mechanisms 150377925 Common - hypothetical protein Smed_5893 9 None None None 150377281 Common - binding-protein-dependent transport systems inner membrane component Smed_5166 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377487 Common - P-type conjugative transfer protein TrbJ Smed_5380 39 COG5314 COG5314, Conjugal transfer/entry exclusion protein Intracellular trafficking and secretion 150378145 Common - sulfate adenylyltransferase subunit 2 Smed_6192 139 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 150377843 Common - transcriptional regulator, XRE family Smed_5804 11 COG1396 HipB, Predicted transcriptional regulators Transcription 150377458 Common - transcriptional regulator, RpiR family Smed_5348 75 COG1737 RpiR, Transcriptional regulators Transcription 150377503 Common - hypothetical protein Smed_5397 3 None None None 150377174 Common - regulatory protein ArsR Smed_5057 66 COG4189 COG4189, Predicted transcriptional regulator Transcription 150378203 Common - Cbb3-type cytochrome oxidase component Smed_6266 10 COG4736 CcoQ, Cbb3-type cytochrome oxidase, subunit 3 Posttranslational modification, protein turnover, chaperones 150378226 Nonpathogen - hypothetical protein Smed_6290 1 None None None 150378154 Common - transcriptional regulator, LysR family Smed_6204 86 COG0583 LysR, Transcriptional regulator Transcription 150378218 Common - hypothetical protein Smed_6282 11 None None None 150377451 Common - inner-membrane translocator Smed_5341 74 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 150377274 Nonpathogen - hypothetical protein Smed_5159 2 None None None 150378062 Nonpathogen - hypothetical protein Smed_6079 1 None None None 150377755 Common - hypothetical protein Smed_5692 9 None None None 150377376 Common - transcriptional regulator, GntR family Smed_5262 119 COG1802 GntR, Transcriptional regulators Transcription 150377387 Common - hypothetical protein Smed_5273 4 None None None 150377179 Common - protein of unknown function DUF81 Smed_5062 25 None None None 150378144 Common - bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein Smed_6191 249 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 150377334 Common - Antibiotic biosynthesis monooxygenase Smed_5219 24 COG1359 COG1359, Uncharacterized conserved protein Function unknown 150377604 Common - RNA-directed DNA polymerase (Reverse transcriptase) Smed_5513 91 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 150377617 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Smed_5529 18 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 150377823 Nonpathogen - hypothetical protein Smed_5779 4 None None None 150378184 Common - binding-protein-dependent transport systems inner membrane component Smed_6247 155 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 150377885 Common - peptidase M24 Smed_5853 72 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 150377531 Nonpathogen - hypothetical protein Smed_5429 1 None None None 150377456 Common - isochorismatase hydrolase Smed_5346 117 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 150377314 Nonpathogen - hypothetical protein Smed_5199 5 None None None 150377226 Common - transcriptional regulator, LysR family Smed_5111 177 COG0583 LysR, Transcriptional regulator Transcription 150377525 Nonpathogen - hypothetical protein Smed_5422 1 None None None 150377419 Common - hypothetical protein Smed_5307 3 None None None 150377536 Common - Site-specific DNA-methyltransferase (adenine-specific) Smed_5436 133 COG2189 COG2189, Adenine specific DNA methylase Mod DNA replication, recombination, and repair 150377767 Common - protein of unknown function DUF1428 Smed_5705 39 COG5507 COG5507, Uncharacterized conserved protein Function unknown 150378198 Nonpathogen - NoeA host specific nodulation protein Smed_6261 6 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 150377491 Common - P-type conjugative transfer protein TrbG Smed_5384 50 COG3504 VirB9, Type IV secretory pathway, VirB9 components Intracellular trafficking and secretion 150377813 Common - NapD-like protein Smed_5769 27 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 150377977 Common - response regulator receiver protein Smed_5953 102 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 150378121 Common - TrbL/VirB6 plasmid conjugal transfer protein Smed_6157 10 COG3704 VirB6, Type IV secretory pathway, VirB6 components Intracellular trafficking and secretion 150378054 Nonpathogen - hypothetical protein Smed_6066 1 None None None 150377184 Common - extracellular solute-binding protein family 5 Smed_5067 201 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 150377986 Nonpathogen - hypothetical protein Smed_5966 4 None None None 150377863 Nonpathogen - hypothetical protein Smed_5830 1 None None None 150377991 Common - Transposase and inactivated derivatives-like protein Smed_5976 49 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 150378097 Common - Integrase catalytic region Smed_6125 149 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 150378006 Common - transcriptional regulator, MucR family Smed_5993 34 COG4957 COG4957, Predicted transcriptional regulator Transcription 150377544 Common - hypothetical protein Smed_5444 2 None None None 150378047 Nonpathogen - hypothetical protein Smed_6058 1 None None None 150377640 Common - periplasmic binding protein/LacI transcriptional regulator Smed_5554 126 COG1609 PurR, Transcriptional regulators Transcription 150377236 Common - type II secretion system protein Smed_5121 70 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 150378103 Nonpathogen - hypothetical protein Smed_6133 1 None None None 150377612 Common - PAS/PAC sensor signal transduction histidine kinase Smed_5522 221 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 150377575 Common - plasmid maintenance system antidote protein, XRE family Smed_5479 74 COG3093 VapI, Plasmid maintenance system antidote protein General function prediction only 150378021 Nonpathogen - hypothetical protein Smed_6012 1 None None None 150377556 Common - extracellular solute-binding protein family 3 Smed_5457 135 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 150377678 Common - hypothetical protein Smed_5596 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 150377563 Common - Xylose isomerase domain protein TIM barrel Smed_5464 40 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 150378259 Common - (2Fe-2S)-binding domain protein Smed_6324 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 150377368 Common - hypothetical protein Smed_5254 3 None None None 150377589 Nonpathogen - hypothetical protein Smed_5497 8 None None None 150377647 Common - 2-hydroxy-3-oxopropionate reductase Smed_5561 186 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 150378250 Common - short-chain dehydrogenase/reductase SDR Smed_6315 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 150377797 Common - putative integral membrane protein Smed_5747 6 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 150377354 Common - aldehyde dehydrogenase Smed_5240 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 150377465 Common - putative xanthine dehydrogenase iron-sulfur-binding subunit Smed_5356 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 150378001 Nonpathogen - hypothetical protein Smed_5988 6 None None None 150378163 Common - nitrogen fixation protein NifX Smed_6221 34 None None None 150377944 Common - ABC transporter related Smed_5912 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 150377343 Common - transcriptional regulator, LysR family Smed_5229 166 COG0583 LysR, Transcriptional regulator Transcription 150377420 Common - hypothetical protein Smed_5308 6 None None None 150377702 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Smed_5622 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377962 Common - cytochrome c oxidase, cbb3-type, subunit III Smed_5932 82 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 150377478 Common - protein of unknown function DUF1127 Smed_5370 8 COG5457 COG5457, Uncharacterized conserved small protein Function unknown 150377735 Common - putative transmembrane protein Smed_5667 9 None None None 150378211 Common - pseudoazurin Smed_6275 24 COG3794 PetE, Plastocyanin Energy production and conversion 150377620 Common - D-cysteine desulfhydrase Smed_5532 60 COG2515 Acd, 1-aminocyclopropane-1-carboxylate deaminase Amino acid transport and metabolism 150377429 Common - inner-membrane translocator Smed_5318 10 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 150377363 Common - phospholipase/Carboxylesterase Smed_5249 46 COG4099 COG4099, Predicted peptidase General function prediction only 150377914 Common - extracellular solute-binding protein family 3 Smed_5882 158 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 150377435 Common - hypothetical protein Smed_5324 41 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 150377326 Common - hypothetical protein Smed_5211 5 None None None 150378204 Common - cytochrome c oxidase, cbb3-type, subunit II Smed_6267 82 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 150378143 Common - ABC-2 type transporter, NodJ family Smed_6188 166 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 150378228 Common - hypothetical protein Smed_6292 4 None None None 150377945 Common - hypothetical protein Smed_5914 34 COG4185 COG4185, Uncharacterized protein conserved in bacteria Function unknown 150377275 Common - fatty acid desaturase Smed_5160 35 COG3239 DesA, Fatty acid desaturase Lipid metabolism 150377753 Nonpathogen - hypothetical protein Smed_5690 1 None None None 150377240 Common - response regulator receiver protein Smed_5125 65 COG4963 CpaE, Flp pilus assembly protein, ATPase CpaE Intracellular trafficking and secretion 150377405 Common - transcriptional regulator, LysR family Smed_5292 180 COG0583 LysR, Transcriptional regulator Transcription 150377854 Common - NmrA family protein Smed_5821 60 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 150377372 Common - hypothetical protein Smed_5258 84 COG0657 Aes, Esterase/lipase Lipid metabolism 150378069 Common - Lanthionine synthetase C family protein Smed_6089 17 COG4403 LcnDR2, Lantibiotic modifying enzyme Defense mechanisms 150377842 Common - prevent-host-death family protein Smed_5802 9 None None None 150377758 Common - cyclic nucleotide-binding protein Smed_5695 60 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 150377457 Common - N-formylglutamate amidohydrolase Smed_5347 41 COG3931 COG3931, Predicted N-formylglutamate amidohydrolase Amino acid transport and metabolism 150377506 Common - transcriptional regulator, XRE family Smed_5402 41 COG1476 COG1476, Predicted transcriptional regulators Transcription 150378221 Common - coproporphyrinogen III oxidase Smed_6285 204 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 150377385 Common - Endoribonuclease L-PSP Smed_5271 60 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 150377580 Nonpathogen - hypothetical protein Smed_5488 3 None None None 150377903 Common - hypothetical protein Smed_5871 21 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 150378214 Common - nitrite reductase, copper-containing Smed_6278 54 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 150378085 Common - protein of unknown function DUF181 Smed_6108 26 COG1944 COG1944, Uncharacterized conserved protein Function unknown 150378155 Nonpathogen - hypothetical protein Smed_6205 1 None None None 150377557 Common - polar amino acid ABC transporter, inner membrane subunit Smed_5458 174 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 150377783 Common - beta-lactamase-like protein Smed_5726 11 None None None 150377824 Common - hypothetical protein Smed_5780 5 None None None 150377923 Common - transcriptional regulator, LysR family Smed_5891 133 COG0583 LysR, Transcriptional regulator Transcription 150378098 Common - putative transposase Smed_6127 45 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 150378177 Common - transcriptional regulator, XRE family Smed_6237 4 COG1396 HipB, Predicted transcriptional regulators Transcription 150377310 Common - Ornithine decarboxylase Smed_5195 86 COG1982 LdcC, Arginine/lysine/ornithine decarboxylases Amino acid transport and metabolism 150377257 Common - putative transmembrane anti-sigma factor Smed_5142 11 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 150377661 Common - Non-specific serine/threonine protein kinase Smed_5577 93 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 150378019 Common - glutamine amidotransferase class-II Smed_6008 237 COG0067 GltB, Glutamate synthase domain 1 Amino acid transport and metabolism 150377305 Common - protein of unknown function DUF344 Smed_5190 127 COG2326 COG2326, Uncharacterized conserved protein Function unknown 150377519 Common - extracellular solute-binding protein family 5 Smed_5416 210 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 150377892 Common - binding-protein-dependent transport systems inner membrane component Smed_5860 181 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 150377989 Common - protein of unknown function DUF1214 Smed_5971 40 COG5361 COG5361, Uncharacterized conserved protein Function unknown 150377430 Common - ABC transporter related Smed_5319 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 150377283 Common - Amidohydrolase 3 Smed_5168 114 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 150377876 Common - N-acylglucosamine 2-epimerase Smed_5844 47 COG2942 COG2942, N-acyl-D-glucosamine 2-epimerase Carbohydrate transport and metabolism 150377270 Common - hypothetical protein Smed_5155 9 None None None 150377634 Common - aldehyde dehydrogenase Smed_5547 196 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 150377296 Common - Nitrate reductase cytochrome c-type subunit (NapB) Smed_5181 41 COG3043 NapB, Nitrate reductase cytochrome c-type subunit Energy production and conversion 150377182 Common - binding-protein-dependent transport systems inner membrane component Smed_5065 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377955 Common - cytochrome c oxidase, cbb3-type, subunit II Smed_5925 82 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 150377967 Common - flavin reductase domain protein FMN-binding Smed_5938 121 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 150378058 Nonpathogen - hypothetical protein Smed_6071 1 None None None 150377191 Common - transcriptional regulator, LysR family Smed_5074 159 COG0583 LysR, Transcriptional regulator Transcription 150377747 Common - conserved hypothetical membrane spanning protein Smed_5683 28 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 150377212 Common - short-chain dehydrogenase/reductase SDR Smed_5097 233 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 150378216 Common - protein of unknown function DUF59 Smed_6280 151 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 150377597 Common - extracellular solute-binding protein, family 1 Smed_5505 62 COG2998 TupB, ABC-type tungstate transport system, permease component Coenzyme metabolism 150377523 Nonpathogen - hypothetical protein Smed_5420 4 None None None 150377799 Common - short-chain dehydrogenase/reductase SDR Smed_5749 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 150377677 Common - HAD-superfamily hydrolase, subfamily IA, variant 2 (HAD-like) Smed_5595 28 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 150377413 Common - hypothetical protein Smed_5301 9 None None None 150377764 Common - Tripartite ATP-independent periplasmic transporter DctQ component Smed_5702 26 COG3090 DctM, TRAP-type C4-dicarboxylate transport system, small permease component Carbohydrate transport and metabolism 150377832 Common - N-ethylammeline chlorohydrolase Smed_5790 137 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 150377206 Common - transcriptional regulator, LysR family Smed_5090 180 COG0583 LysR, Transcriptional regulator Transcription 150378003 Common - Xylose isomerase domain protein TIM barrel Smed_5990 12 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 150377337 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase Smed_5223 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 150377606 Common - IS66 Orf2 family protein Smed_5515 47 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377776 Nonpathogen - hypothetical protein Smed_5717 1 None None None 150377397 Common - protein of unknown function DUF344 Smed_5283 127 COG2326 COG2326, Uncharacterized conserved protein Function unknown 150378117 Common - conjugation TrbI family protein Smed_6153 59 COG2948 VirB10, Type IV secretory pathway, VirB10 components Intracellular trafficking and secretion 150377915 Common - periplasmic binding protein/LacI transcriptional regulator Smed_5883 127 COG1609 PurR, Transcriptional regulators Transcription 150378245 Common - histidinol dehydrogenase Smed_6310 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 150377427 Common - Gluconolactonase Smed_5316 87 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 150377579 Common - molybdenum cofactor synthesis domain Smed_5487 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 150378238 Common - hypothetical protein Smed_6303 3 None None None 150378165 Common - nitrogenase molybdenum-iron protein beta chain Smed_6223 55 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 150377375 Common - Malate/L-lactate dehydrogenase Smed_5261 67 COG2055 COG2055, Malate/L-lactate dehydrogenases Energy production and conversion 150377709 Nonpathogen - hypothetical protein Smed_5630 2 None None None 150377495 Nonpathogen - conjugal transfer transcriptional regulator (repressor) protein Smed_5388 2 None None None 150377700 Common - binding-protein-dependent transport systems inner membrane component Smed_5620 218 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377328 Nonpathogen - hypothetical protein Smed_5213 1 None None None 150377476 Common - Peptidoglycan glycosyltransferase Smed_5367 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 150377365 Common - hypothetical protein Smed_5251 4 None None None 150377466 Nonpathogen - hypothetical protein Smed_5357 1 None None None 150378126 Common - Lytic transglycosylase catalytic Smed_6162 23 None None None 150377626 Common - 2-nitropropane dioxygenase NPD Smed_5538 125 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 150377729 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Smed_5658 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377208 Common - 3-oxoacid CoA-transferase, A subunit Smed_5092 97 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 150377736 Common - secretion protein HlyD family protein Smed_5668 127 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 150377691 Common - SNARE associated Golgi protein Smed_5610 100 COG1238 COG1238, Predicted membrane protein Function unknown 150378045 Common - Methyltransferase type 11 Smed_6054 82 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 150377698 Common - transcriptional regulator, GntR family Smed_5617 137 COG1802 GntR, Transcriptional regulators Transcription 150377201 Common - Enoyl-CoA hydratase/isomerase Smed_5085 182 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 150377794 Common - putative ABC transporter, periplasmic solute-binding protein Smed_5744 94 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 150377219 Common - binding-protein-dependent transport systems inner membrane component Smed_5104 179 COG1174 OpuBB, ABC-type proline/glycine betaine transport systems, permease component Amino acid transport and metabolism 150377869 Common - transcriptional regulator, GntR family Smed_5836 140 COG1802 GntR, Transcriptional regulators Transcription 150377398 Common - Uncharacterized protein UPF0065 Smed_5284 65 COG3181 COG3181, Uncharacterized protein conserved in bacteria Function unknown 150377718 Common - MscS Mechanosensitive ion channel Smed_5647 134 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 150378088 Nonpathogen - hypothetical protein Smed_6111 1 None None None 150377874 Common - SMP-30/Gluconolaconase/LRE domain protein Smed_5842 69 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 150377294 Common - NapD family protein Smed_5179 6 COG3062 NapD, Uncharacterized protein involved in formation of periplasmic nitrate reductase Inorganic ion transport and metabolism 150377432 Common - putative signal transduction histidine kinase Smed_5321 142 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 150378119 Common - VirB8 family protein Smed_6155 26 COG3736 VirB8, Type IV secretory pathway, component VirB8 Intracellular trafficking and secretion 150378037 Nonpathogen - hypothetical protein Smed_6040 1 None None None 150377788 Nonpathogen - hypothetical protein Smed_5738 1 None None None 150378123 Common - type IV secretion/conjugal transfer ATPase, VirB4 family Smed_6159 56 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 150377723 Common - hypothetical protein Smed_5652 23 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 150377819 Common - CheB methylesterase Smed_5775 150 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 150377448 Common - basic membrane lipoprotein Smed_5338 101 COG1744 Med, Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein General function prediction only 150378053 Common - putative cold-shock DNA-binding domain protein Smed_6064 164 COG1278 CspC, Cold shock proteins Transcription 150378252 Common - hypothetical protein Smed_6317 20 COG5276 COG5276, Uncharacterized conserved protein Function unknown 150377668 Common - transcriptional regulator, TrmB Smed_5584 10 COG4189 COG4189, Predicted transcriptional regulator Transcription 150377972 Common - hypothetical protein Smed_5946 2 COG3318 COG3318, Predicted metal-binding protein related to the C-terminal domain of SecA General function prediction only 150377652 Common - short-chain dehydrogenase/reductase SDR Smed_5566 222 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 150377273 Nonpathogen - hypothetical protein Smed_5158 1 None None None 150378175 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Smed_6234 104 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 150377684 Common - aldehyde dehydrogenase Smed_5602 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 150377330 Common - helix-turn-helix- domain containing protein AraC type Smed_5215 157 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 150377985 Nonpathogen - hypothetical protein Smed_5964 4 None None None 150377537 Common - type III restriction protein res subunit Smed_5437 30 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 150378233 Common - hypothetical protein Smed_6297 14 COG3154 COG3154, Putative lipid carrier protein Lipid metabolism 150378186 Common - extracellular solute-binding protein family 1 Smed_6249 67 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 150377542 Common - transcriptional regulator Smed_5442 39 COG2378 COG2378, Predicted transcriptional regulator Transcription 150378138 Common - transcriptional regulator, LysR family Smed_6183 89 COG0583 LysR, Transcriptional regulator Transcription 150377317 Common - arginine deiminase Smed_5202 51 COG2235 ArcA, Arginine deiminase Amino acid transport and metabolism 150377887 Common - hypothetical protein Smed_5855 19 COG5564 COG5564, Predicted TIM-barrel enzyme, possibly a dioxygenase General function prediction only 150377321 Nonpathogen - hypothetical protein Smed_5206 1 None None None 150377228 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Smed_5113 196 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 150377867 Common - Monosaccharide-transporting ATPase Smed_5834 111 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 150377510 Common - phage integrase family protein Smed_5407 127 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 150378056 Common - hypothetical protein Smed_6068 2 None None None 150378157 Nonpathogen - hypothetical protein Smed_6211 1 None None None 150378083 Common - protein of unknown function DUF181 Smed_6106 42 COG1944 COG1944, Uncharacterized conserved protein Function unknown 150377655 Common - putative transmembrane protein Smed_5570 27 None None None 150378236 Nonpathogen - hypothetical protein Smed_6301 1 None None None 150378112 Common - two component transcriptional regulator, winged helix family Smed_6145 215 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 150377901 Common - Glutathione S-transferase domain Smed_5869 88 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 150377508 Common - putative transcriptional regulator, XRE family Smed_5405 19 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 150377261 Common - chaperone DnaJ domain protein Smed_5146 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 150377781 Nonpathogen - hypothetical protein Smed_5723 7 None None None 150377559 Common - ornithine cyclodeaminase/mu-crystallin Smed_5460 82 COG2423 COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog Amino acid transport and metabolism 150377693 Common - protein of unknown function DUF156 Smed_5612 69 COG1937 COG1937, Uncharacterized protein conserved in bacteria Function unknown 150378067 Common - nuclease (SNase domain protein) Smed_6085 27 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 150377849 Common - NADP oxidoreductase coenzyme F420-dependent Smed_5815 38 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 150377938 Common - putative tricarboxylic transport membrane protein Smed_5906 7 None None None 150377615 Nonpathogen - hypothetical protein Smed_5525 12 None None None 150377339 Common - short-chain dehydrogenase/reductase SDR Smed_5225 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 150377774 Common - transposase IS3/IS911 family protein Smed_5715 53 None None None 150377312 Common - cation efflux protein Smed_5197 34 COG3965 COG3965, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 150377878 Common - transcriptional regulator, TetR family Smed_5846 24 COG1309 AcrR, Transcriptional regulator Transcription 150378206 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Smed_6269 11 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 150377921 Common mtnK methylthioribose kinase Smed_5889 29 COG4857 COG4857, Predicted kinase General function prediction only 150377958 Common - cytochrome oxidase maturation protein, cbb3-type Smed_5928 18 COG3197 FixS, Uncharacterized protein, possibly involved in nitrogen fixation Inorganic ion transport and metabolism 150378171 Common - FAD dependent oxidoreductase Smed_6230 128 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 150377268 Common - diguanylate cyclase/phosphodiesterase Smed_5153 178 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 150378091 Nonpathogen - hypothetical protein Smed_6114 1 None None None 150377947 Nonpathogen - hypothetical protein Smed_5917 2 None None None 150377455 Common - Extracellular ligand-binding receptor Smed_5345 131 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 150377929 Common - hypothetical protein Smed_5897 9 None None None 150377370 Common - hypothetical protein Smed_5256 11 None None None 150377811 Common - transposase IS3/IS911 family protein Smed_5766 17 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377917 Common - transcriptional regulator, DeoR family Smed_5885 64 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 150377910 Common - major facilitator superfamily MFS_1 Smed_5878 32 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 150377277 Common - putative cold-shock DNA-binding domain protein Smed_5162 177 COG1278 CspC, Cold shock proteins Transcription 150377180 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Smed_5063 249 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 150378141 Common - glycosyl transferase family 2 Smed_6186 127 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 150377707 Nonpathogen - hypothetical protein Smed_5627 1 None None None 150378223 Common - ATPase associated with various cellular activities AAA_5 Smed_6287 80 COG0714 COG0714, MoxR-like ATPases General function prediction only 150377840 Common - WGR domain protein Smed_5799 16 COG3831 COG3831, Uncharacterized conserved protein Function unknown 150377550 Common - transposase IS204/IS1001/IS1096/IS1165 family protein Smed_5451 51 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 150378150 Common - transposase IS3/IS911 family protein Smed_6197 15 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377272 Common - amino acid carrier protein Smed_5157 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 150377242 Common - peptidase A24A prepilin type IV Smed_5127 14 COG4960 CpaA, Flp pilus assembly protein, protease CpaA Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 150377980 Nonpathogen - protein of unknown function DUF1614 Smed_5957 27 COG4089 COG4089, Predicted membrane protein Function unknown 150377751 Common - glycosyl transferase group 1 Smed_5687 197 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 150377650 Nonpathogen - hypothetical protein Smed_5564 5 None None None 150377214 Common - RES domain protein Smed_5099 11 COG5654 COG5654, Uncharacterized conserved protein Function unknown 150377600 Common - helix-turn-helix- domain containing protein AraC type Smed_5508 92 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 150377513 Nonpathogen - hypothetical protein Smed_5410 1 None None None 150377395 Common - NmrA family protein Smed_5281 71 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 150377675 Common - binding-protein-dependent transport systems inner membrane component Smed_5593 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377762 Common - transcriptional regulator, GntR family Smed_5700 68 COG1802 GntR, Transcriptional regulators Transcription 150377826 Nonpathogen - hypothetical protein Smed_5782 1 None None None 150377834 Common - binding-protein-dependent transport systems inner membrane component Smed_5792 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377599 Common - molybdenum cofactor synthesis domain Smed_5507 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 150378193 Nonpathogen - hypothetical protein Smed_6256 1 None None None 150377204 Common - cobalamin B12-binding domain protein Smed_5088 111 COG2185 Sbm, Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) Lipid metabolism 150378247 Common - binding-protein-dependent transport systems inner membrane component Smed_6312 196 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 150377749 Common - UDP-galactopyranose mutase Smed_5685 84 COG0562 Glf, UDP-galactopyranose mutase Cell envelope biogenesis, outer membrane 150377590 Nonpathogen - hypothetical protein Smed_5498 9 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 150377345 Common - helix-turn-helix- domain containing protein AraC type Smed_5231 69 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 150377529 Nonpathogen - hypothetical protein Smed_5427 1 None None None 150377193 Common - diaminopropionate ammonia-lyase Smed_5076 94 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 150377255 Nonpathogen - hypothetical protein Smed_5140 3 None None None 150377889 Common - transcriptional regulator, TetR family Smed_5857 11 COG1309 AcrR, Transcriptional regulator Transcription 150378079 Common - molybdopterin biosynthesis protein MoeB Smed_6102 223 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 150377244 Common - hypothetical protein Smed_5129 13 COG4964 CpaC, Flp pilus assembly protein, secretin CpaC Intracellular trafficking and secretion 150377298 Nonpathogen - hypothetical protein Smed_5183 4 None None None 150377189 Common - ferredoxin Smed_5072 8 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 150377740 Common - diguanylate cyclase/phosphodiesterase Smed_5672 178 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 150378115 Common - hypothetical protein Smed_6151 79 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 150378132 Nonpathogen - hypothetical protein Smed_6176 1 None None None 150378010 Nonpathogen - hypothetical protein Smed_5997 1 None None None 150378012 Nonpathogen - hypothetical protein Smed_5999 1 None None None 150377999 Common - putative dehydrogenase large subunit protein Smed_5986 64 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 150378032 Common - hypothetical protein Smed_6030 12 COG5591 COG5591, Uncharacterized conserved protein Function unknown 150377960 Common - FixH family protein Smed_5930 17 COG5456 COG5456, Predicted integral membrane protein linked to a cation pump Inorganic ion transport and metabolism 150377632 Nonpathogen - hypothetical protein Smed_5544 1 None None None 150377953 Common - cytochrome c oxidase, cbb3-type, subunit III Smed_5923 78 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 150377461 Common - sodium/hydrogen exchanger Smed_5351 92 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 150378043 Common - thiamine pyrophosphate protein domain protein TPP-binding Smed_6051 137 COG3961 COG3961, Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only 150377285 Common - peptidase S58 DmpA Smed_5170 38 COG3191 DmpA, L-aminopeptidase/D-esterase Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 150378086 Nonpathogen - hypothetical protein Smed_6109 1 None None None 150377350 Common - peptidase M20 Smed_5236 93 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 150378048 Nonpathogen - hypothetical protein Smed_6059 1 None None None 150378231 Common - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Smed_6295 152 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 150377738 Common - Plasmid stability protein-like protein Smed_5670 25 COG4691 StbC, Plasmid stability protein General function prediction only 150377645 Common - ABC transporter related Smed_5559 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 150377359 Common - Arginase/agmatinase/formiminoglutamase Smed_5245 62 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 150377673 Common - ABC transporter related Smed_5591 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 150377806 Common - putative circadian clock protein, KaiC Smed_5757 85 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 150377725 Common - hypothetical protein Smed_5654 14 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 150377553 Common - Domain of unknown function DUF1814 Smed_5454 23 COG2253 COG2253, Uncharacterized conserved protein Function unknown 150377303 Common - hypothetical protein Smed_5188 8 None None None 150377323 Common - Cellulose synthase (UDP-forming) Smed_5208 142 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 150377769 Common - Cupin 2 conserved barrel domain protein Smed_5708 17 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 150378005 Common - thiamine pyrophosphate protein TPP binding domain protein Smed_5992 221 COG3961 COG3961, Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only 150378209 Common fixJ response regulator FixJ Smed_6273 219 COG4566 TtrR, Response regulator Signal transduction mechanisms 150378188 Common - aldehyde dehydrogenase Smed_6251 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 150377403 Common - transcriptional regulator, LysR family Smed_5289 98 COG0583 LysR, Transcriptional regulator Transcription 150377716 Nonpathogen - hypothetical protein Smed_5643 1 None None None 150377639 Nonpathogen - hypothetical protein Smed_5553 2 None None None 150377997 Nonpathogen - hypothetical protein Smed_5983 1 None None None 150377583 Common - molybdopterin oxidoreductase Smed_5491 189 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 150377731 Common - extracellular solute-binding protein family 5 Smed_5662 214 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 150377760 Common - shikimate 5-dehydrogenase Smed_5698 193 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 150377367 Common - putative integral membrane protein TIGR02587 Smed_5253 9 COG4711 COG4711, Predicted membrane protein Function unknown 150377727 Common - binding-protein-dependent transport systems inner membrane component Smed_5656 224 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377560 Common - transcriptional regulator, GntR family Smed_5461 111 COG2188 PhnF, Transcriptional regulators Transcription 150377472 Common - protein of unknown function DUF81 Smed_5363 30 COG0730 COG0730, Predicted permeases General function prediction only 150377624 Common - Endoribonuclease L-PSP Smed_5536 92 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 150377474 Nonpathogen - hypothetical protein Smed_5365 1 None None None 150378128 Common - feruloyl esterase Smed_6166 51 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 150378167 Common nifH nitrogenase reductase Smed_6225 77 COG1348 NifH, Nitrogenase subunit NifH (ATPase) Inorganic ion transport and metabolism 150377908 Common - inner-membrane translocator Smed_5876 108 COG1079 COG1079, Uncharacterized ABC-type transport system, permease component General function prediction only 150377682 Common - succinic semialdehyde dehydrogenase Smed_5600 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 150377983 Nonpathogen - hypothetical protein Smed_5960 2 COG5555 COG5555, Cytolysin, a secreted calcineurin-like phosphatase Cell motility and secretion 150377235 Common - type II secretion system protein Smed_5120 71 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion 150377821 Common - response regulator receiver protein Smed_5777 28 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 150378074 Nonpathogen - hypothetical protein Smed_6096 1 None None None 150377613 Common - response regulator receiver protein Smed_5523 194 COG4566 TtrR, Response regulator Signal transduction mechanisms 150377535 Common - hypothetical protein Smed_5434 7 None None None 150377439 Common - Alcohol dehydrogenase zinc-binding domain protein Smed_5329 180 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 150377415 Nonpathogen - hypothetical protein Smed_5303 1 None None None 150377425 Common - hypothetical protein Smed_5313 14 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 150378022 Common - filamentation induced by cAMP protein Fic Smed_6016 105 COG3177 COG3177, Uncharacterized conserved protein Function unknown 150378030 Common - integral membrane sensor signal transduction histidine kinase Smed_6028 176 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 150377319 Common - carbamate kinase Smed_5204 65 COG0549 ArcC, Carbamate kinase Amino acid transport and metabolism 150377808 Common - OmpA/MotB domain protein Smed_5762 166 COG3900 COG3900, Predicted periplasmic protein Function unknown 150377332 Common - flavin reductase domain protein FMN-binding Smed_5217 54 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 150377441 Common - catalase/peroxidase HPI Smed_5331 98 COG0376 KatG, Catalase (peroxidase I) Inorganic ion transport and metabolism 150378039 Nonpathogen - hypothetical protein Smed_6043 1 None None None 150378081 Nonpathogen - hypothetical protein Smed_6104 1 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 150377817 Nonpathogen - hypothetical protein Smed_5773 1 None None None 150378151 Common - IS66 Orf2 family protein Smed_6198 46 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377567 Common - extracellular solute-binding protein family 1 Smed_5469 52 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 150377223 Common - peptidase M24 Smed_5108 162 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 150377793 Common - ABC transporter related Smed_5743 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 150377468 Common - potassium-transporting ATPase subunit B Smed_5359 232 COG2216 KdpB, High-affinity K+ transport system, ATPase chain B Inorganic ion transport and metabolism 150378106 Common - diguanylate cyclase/phosphodiesterase Smed_6138 179 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 150377484 Common - Conjugal transfer protein TrbC Smed_5377 8 COG3838 VirB2, Type IV secretory pathway, VirB2 components (pilins) Intracellular trafficking and secretion 150377570 Common - dihydrodipicolinate synthetase Smed_5472 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 150377866 Common - ABC transporter related Smed_5833 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 150377720 Common - hypothetical protein Smed_5649 61 COG2910 COG2910, Putative NADH-flavin reductase General function prediction only 150377539 Common - hypothetical protein Smed_5439 9 None None None 150377347 Nonpathogen - hypothetical protein Smed_5233 1 None None None 150377187 Common - extracellular solute-binding protein family 5 Smed_5070 205 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 150377761 Nonpathogen - hypothetical protein Smed_5699 1 None None None 150377423 Common - hypothetical protein Smed_5311 4 None None None 150377870 Common - Mandelate racemase/muconate lactonizing protein Smed_5837 104 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 150377540 Common - UvrD/REP helicase Smed_5440 210 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 150377829 Common - transcriptional regulator, GntR family Smed_5787 131 COG1802 GntR, Transcriptional regulators Transcription 150378034 Common - transposase mutator type Smed_6034 87 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 150378173 Common - transcriptional regulator, NifA, Fis Family Smed_6232 168 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 150378146 Common - 3-ketoacyl-(acyl-carrier-protein) reductase NodG Smed_6193 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 150377978 Common - integral membrane sensor signal transduction histidine kinase Smed_5954 218 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 150377492 Common - conjugal transfer protein H Smed_5385 4 None None None 150378116 Common - P-type DNA transfer ATPase VirB11 Smed_6152 218 COG0630 VirB11, Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis Cell motility and secretion / Intracellular trafficking and secretion 150377443 Common - cytosine deaminase Smed_5333 80 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 150377712 Common - response regulator receiver protein Smed_5633 219 COG4566 TtrR, Response regulator Signal transduction mechanisms 150377816 Common - MscS Mechanosensitive ion channel Smed_5772 109 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 150377549 Common - alpha/beta hydrolase fold Smed_5449 199 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 150378234 Common - peptidase U32 Smed_6298 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 150377514 Common - peptidase T Smed_5411 62 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 150378191 Common - alpha/beta hydrolase fold Smed_6254 121 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 150377527 Common - RES domain protein Smed_5424 29 COG5654 COG5654, Uncharacterized conserved protein Function unknown 150377176 Common - alpha/beta hydrolase fold Smed_5059 119 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 150377602 Common - yecA family protein Smed_5511 11 COG3318 COG3318, Predicted metal-binding protein related to the C-terminal domain of SecA General function prediction only 150377289 Common - parB-like partition protein Smed_5174 89 COG1475 Spo0J, Predicted transcriptional regulators Transcription 150377171 Common - arsenical-resistance protein Smed_5054 131 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 150377822 Common - GCN5-related N-acetyltransferase Smed_5778 57 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 150378181 Common - transposase IS3/IS911 family protein Smed_6244 6 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 150377530 Nonpathogen - hypothetical protein Smed_5428 3 None None None 150377941 Common - globin Smed_5909 44 COG2346 COG2346, Truncated hemoglobins General function prediction only 150377360 Common - hypothetical protein Smed_5246 9 None None None 150377911 Common - putative transcriptional regulator, AsnC family Smed_5879 154 COG1522 Lrp, Transcriptional regulators Transcription 150378180 Common - transposase IS3/IS911 family protein Smed_6241 53 None None None 150377378 Common - Monosaccharide-transporting ATPase Smed_5264 113 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 150378251 Common - histidinol-phosphate aminotransferase Smed_6316 231 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 150377436 Common - Redoxin domain protein Smed_5325 92 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 150377648 Common - Hydroxypyruvate reductase Smed_5562 86 COG2379 GckA, Putative glycerate kinase Carbohydrate transport and metabolism 150377742 Common - transposase IS3/IS911 family protein Smed_5675 4 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 150378073 Common - RNA-directed DNA polymerase (Reverse transcriptase) Smed_6095 91 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 150377325 Common - Cellulase Smed_5210 35 COG3405 CelA, Endoglucanase Y Carbohydrate transport and metabolism 150377225 Nonpathogen - trimethylamine methyltransferase Smed_5110 12 COG5598 COG5598, Trimethylamine:corrinoid methyltransferase Coenzyme metabolism 150377572 Common - pyrroline-5-carboxylate reductase Smed_5474 209 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 150378060 Common - transcriptional regulator, XRE family Smed_6073 38 COG1396 HipB, Predicted transcriptional regulators Transcription 150377621 Common - NADPH-dependent FMN reductase Smed_5533 73 COG0431 COG0431, Predicted flavoprotein General function prediction only 150377659 Common - transcriptional regulator, LysR family Smed_5574 172 COG0583 LysR, Transcriptional regulator Transcription 150377380 Common - intracellular protease, PfpI family Smed_5266 120 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 150378212 Common - putative transcriptional regulator, Crp/Fnr family Smed_6276 170 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 150377790 Common - hypothetical protein Smed_5740 3 None None None 150377968 Common - hypothetical protein Smed_5939 71 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377779 Common - aldehyde dehydrogenase Smed_5721 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 150377695 Common - putative ORF1 (plasmid pTOM9) Smed_5614 34 None None None 150377607 Common - transposase IS3/IS911 family protein Smed_5516 25 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377614 Common - PAS/PAC sensor signal transduction histidine kinase Smed_5524 214 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 150378046 Common - transcriptional regulator, MucR family Smed_6057 34 COG4957 COG4957, Predicted transcriptional regulator Transcription 150377500 Common - TraC family protein Smed_5394 6 None None None 150377672 Common - putative transcriptional regulator, AsnC family Smed_5590 149 COG1522 Lrp, Transcriptional regulators Transcription 150377803 Common - regulatory protein LacI Smed_5753 50 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 150377971 Nonpathogen - hypothetical protein Smed_5945 1 None None None 150377355 Common - periplasmic binding protein/LacI transcriptional regulator Smed_5241 77 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 150378162 Common - protein of unknown function DUF683 Smed_6220 14 COG5420 COG5420, Uncharacterized conserved small protein containing a coiled-coil domain Function unknown 150378041 Nonpathogen - hypothetical protein Smed_6048 2 None None None 150377995 Common - transcriptional regulator, LysR family Smed_5980 112 COG0583 LysR, Transcriptional regulator Transcription 150378094 Common - hypothetical protein Smed_6120 2 None None None 150377586 Common - hypothetical protein Smed_5494 12 None None None 150378113 Common - GTPase - Sulfate adenylate transferase subunit 1-like protein Smed_6146 68 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 150377230 Common - Protein-glutamate O-methyltransferase Smed_5115 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 150377734 Common - protein of unknown function UPF0118 Smed_5665 107 COG0628 PerM, Predicted permease General function prediction only 150377462 Common - putative adenylate/guanylate cyclase Smed_5352 53 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 150377880 Common - Activator of Hsp90 ATPase 1 family protein Smed_5848 15 COG3832 COG3832, Uncharacterized conserved protein Function unknown 150377641 Common - extracellular solute-binding protein family 5 Smed_5555 148 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 150378102 Common - multicopper oxidase type 3 Smed_6131 70 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 150377509 Common - phage integrase family protein Smed_5406 149 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 150378015 Common - formyltetrahydrofolate deformylase Smed_6004 219 COG0788 PurU, Formyltetrahydrofolate hydrolase Nucleotide transport and metabolism 150377301 Common - hypothetical protein Smed_5186 21 COG5616 COG5616, Predicted integral membrane protein Function unknown 150377382 Common - protein tyrosine phosphatase Smed_5268 16 COG5350 COG5350, Predicted protein tyrosine phosphatase General function prediction only 150377963 Common - Cbb3-type cytochrome oxidase component Smed_5933 10 COG4736 CcoQ, Cbb3-type cytochrome oxidase, subunit 3 Posttranslational modification, protein turnover, chaperones 150378240 Common - hypothetical protein Smed_6305 4 None None None 150378254 Nonpathogen - hypothetical protein Smed_6319 1 None None None 150377859 Nonpathogen - hypothetical protein Smed_5826 1 None None None 150377251 Common - TRAP dicarboxylate transporter, DctM subunit Smed_5136 125 COG1593 DctQ, TRAP-type C4-dicarboxylate transport system, large permease component Carbohydrate transport and metabolism 150378108 Common - Carbonate dehydratase Smed_6140 52 COG3338 Cah, Carbonic anhydrase Inorganic ion transport and metabolism 150377299 Common fixK transcriptional regulator FixK Smed_5184 111 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 150377861 Common - short-chain dehydrogenase/reductase SDR Smed_5828 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 150377258 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Smed_5143 158 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 150377253 Common - malonyl-CoA synthase Smed_5138 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 150377643 Common - binding-protein-dependent transport systems inner membrane component Smed_5557 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377772 Nonpathogen - hypothetical protein Smed_5711 1 None None None 150378111 Common - TRAG family protein Smed_6143 72 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 150377247 Common - type II and III secretion system protein Smed_5132 138 COG4964 CpaC, Flp pilus assembly protein, secretin CpaC Intracellular trafficking and secretion 150377585 Common - cytoplasmic chaperone TorD family protein Smed_5493 31 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 150377993 Common - ferredoxin Smed_5978 138 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 150377233 Common - CheA signal transduction histidine kinase Smed_5118 224 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 150377197 Common - extracellular solute-binding protein family 5 Smed_5080 173 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 150377340 Common - TrpR binding protein WrbA Smed_5226 103 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 150377666 Common - extracellular solute-binding protein family 1 Smed_5582 94 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 150377481 Common - transcriptional regulator, LysR family Smed_5373 182 COG0583 LysR, Transcriptional regulator Transcription 150377906 Common - ABC transporter related Smed_5874 249 COG3845 COG3845, ABC-type uncharacterized transport systems, ATPase components General function prediction only 150378009 Common - amino acid carrier protein Smed_5996 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 150377680 Common - haloacid dehalogenase, type II Smed_5598 41 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 150378076 Common - IS66 Orf2 family protein Smed_6098 47 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377950 Common - copper-translocating P-type ATPase Smed_5920 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 150377313 Common - amino acid permease-associated region Smed_5198 190 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 150377656 Common - OsmC family protein Smed_5571 83 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 150377837 Common - extracellular solute-binding protein family 5 Smed_5796 197 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 150377744 Nonpathogen - hypothetical protein Smed_5677 1 None None None 150377756 Common - hypothetical protein Smed_5693 13 None None None 150378057 Nonpathogen - hypothetical protein Smed_6070 1 None None None 150377392 Common - peptidase domain protein Smed_5278 93 COG2931 COG2931, RTX toxins and related Ca2+-binding proteins Secondary metabolites biosynthesis, transport, and catabolism 150377271 Common - hypothetical protein Smed_5156 11 None None None 150377547 Nonpathogen - hypothetical protein Smed_5447 1 None None None 150377689 Common - major facilitator superfamily MFS_1 Smed_5608 15 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 150377502 Common - Ti-type conjugative transfer system TraG Smed_5396 62 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 150377835 Common - binding-protein-dependent transport systems inner membrane component Smed_5793 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150378065 Common groES co-chaperonin GroES Smed_6083 216 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 150378261 Common - transcriptional regulator, LysR family Smed_6327 185 COG0583 LysR, Transcriptional regulator Transcription 150377705 Common - IstB domain protein ATP-binding protein Smed_5625 106 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 150377949 Common - cytochrome oxidase maturation protein, cbb3-type Smed_5919 45 COG3197 FixS, Uncharacterized protein, possibly involved in nitrogen fixation Inorganic ion transport and metabolism 150377404 Common - TrpR binding protein WrbA Smed_5291 120 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 150377488 Nonpathogen - hypothetical protein Smed_5381 1 None None None 150377890 Common - extracellular solute-binding protein family 1 Smed_5858 84 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 150377846 Common - short-chain dehydrogenase/reductase SDR Smed_5810 227 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 150377592 Common - cytochrome c class I Smed_5500 96 COG2319 COG2319, FOG: WD40 repeat General function prediction only 150377928 Common - sulfate ABC transporter, periplasmic sulfate-binding protein Smed_5896 89 COG1613 Sbp, ABC-type sulfate transport system, periplasmic component Inorganic ion transport and metabolism 150377173 Common - protein tyrosine phosphatase Smed_5056 122 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 150378200 Common - Maltose O-acetyltransferase Smed_6263 208 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 150377450 Common - isochorismatase hydrolase Smed_5340 80 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 150377366 Common - hypothetical protein Smed_5252 7 None None None 150377785 Nonpathogen - hypothetical protein Smed_5730 1 None None None 150377215 Common - hypothetical protein Smed_5100 10 None None None 150377934 Common - transcriptional regulator, LysR family Smed_5902 191 COG0583 LysR, Transcriptional regulator Transcription 150377939 Common - protein of unknown function DUF112 transmembrane Smed_5907 75 COG3333 COG3333, Uncharacterized protein conserved in bacteria Function unknown 150377920 Common - ABC transporter related Smed_5888 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 150377631 Nonpathogen - hypothetical protein Smed_5543 7 None None None 150377358 Common - GCN5-related N-acetyltransferase Smed_5244 16 COG0456 RimI, Acetyltransferases General function prediction only 150377848 Nonpathogen - hypothetical protein Smed_5813 1 None None None 150377262 Common - Endonuclease/exonuclease/phosphatase Smed_5147 3 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 150377287 Common - Hemolysin-type calcium-binding region Smed_5172 76 None None None 150377638 Nonpathogen - hypothetical protein Smed_5552 1 None None None 150377899 Common - Xylose isomerase domain protein TIM barrel Smed_5867 38 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 150377264 Common - hypothetical protein Smed_5149 25 COG4898 COG4898, Uncharacterized protein conserved in bacteria Function unknown 150377290 Common - replication protein C Smed_5175 18 None None None 150377353 Common - transcriptional regulator, GntR family Smed_5239 125 COG1802 GntR, Transcriptional regulators Transcription 150377591 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Smed_5499 62 COG1148 HdrA, Heterodisulfide reductase, subunit A and related polyferredoxins Energy production and conversion 150377499 Common - Ti-type conjugative transfer relaxase TraA Smed_5393 107 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 150377714 Common - protein of unknown function DUF1254 Smed_5641 38 COG5361 COG5361, Uncharacterized conserved protein Function unknown 150377554 Common - PfkB domain protein Smed_5455 79 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 150377421 Common - helix-turn-helix- domain containing protein AraC type Smed_5309 88 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 150377512 Common - domain of unknown function DUF1738 Smed_5409 48 COG4227 COG4227, Antirestriction protein DNA replication, recombination, and repair 150378153 Common - phage integrase family protein Smed_6201 109 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 150377524 Common - putative cold-shock DNA-binding domain protein Smed_5421 176 COG1278 CspC, Cold shock proteins Transcription 150377517 Common - binding-protein-dependent transport systems inner membrane component Smed_5414 219 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377657 Common - methionine sulfoxide reductase A Smed_5572 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 150378210 Common - multi-sensor signal transduction histidine kinase Smed_6274 223 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 150377227 Common - FAD dependent oxidoreductase Smed_5112 183 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 150377766 Common - 3-dehydroquinate dehydratase Smed_5704 169 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 150377679 Common - GCN5-related N-acetyltransferase Smed_5597 33 COG2153 ElaA, Predicted acyltransferase General function prediction only 150377178 Common - short-chain dehydrogenase/reductase SDR Smed_5061 213 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 150377320 Nonpathogen - hypothetical protein Smed_5205 7 None None None 150377670 Common - short-chain dehydrogenase family protein Smed_5588 19 None None None 150378197 Nonpathogen - NoeB host specific nodulation protein Smed_6260 1 None None None 150377400 Nonpathogen - hypothetical protein Smed_5286 2 None None None 150377411 Nonpathogen - hypothetical protein Smed_5299 1 None None None 150378139 Common - acyltransferase NodA Smed_6184 6 None None None 150378133 Common - D-fructose-6-phosphate amidotransferase Smed_6177 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 150378183 Common - ABC transporter related Smed_6246 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 150377315 Common - hypothetical protein Smed_5200 18 None None None 150377335 Common - short-chain dehydrogenase/reductase SDR Smed_5220 238 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 150377884 Nonpathogen - hypothetical protein Smed_5852 2 None None None 150378190 Common - flavin reductase domain protein FMN-binding Smed_6253 127 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 150377362 Common - Endonuclease/exonuclease/phosphatase Smed_5248 13 COG2374 COG2374, Predicted extracellular nuclease General function prediction only 150377864 Common - Aldose 1-epimerase Smed_5831 44 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 150378055 Common - hypothetical protein Smed_6067 3 None None None 150377407 Common - Activator of Hsp90 ATPase 1 family protein Smed_5295 17 COG3832 COG3832, Uncharacterized conserved protein Function unknown 150377990 Nonpathogen - hypothetical protein Smed_5972 1 None None None 150377708 Common - hypothetical protein Smed_5629 13 None None None 150377801 Common - Xylose isomerase domain protein TIM barrel Smed_5751 16 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 150377249 Common - TRAP dicarboxylate transporter- DctP subunit Smed_5134 84 COG1638 DctP, TRAP-type C4-dicarboxylate transport system, periplasmic component Carbohydrate transport and metabolism 150377987 Common - WGR domain protein Smed_5967 15 COG3831 COG3831, Uncharacterized conserved protein Function unknown 150377976 Common - signal transduction histidine kinase Smed_5952 218 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 150377722 Common - NmrA family protein Smed_5651 66 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 150377185 Common - Amidase Smed_5068 220 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 150377490 Common - Conjugal transfer protein Smed_5383 33 COG3701 TrbF, Type IV secretory pathway, TrbF components Intracellular trafficking and secretion 150377636 Common - PAS/PAC sensor signal transduction histidine kinase Smed_5550 205 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 150377357 Common - ABC transporter related Smed_5243 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 150377710 Nonpathogen - hypothetical protein Smed_5631 1 None None None 150378050 Nonpathogen - hypothetical protein Smed_6061 1 None None None 150377445 Common - inner-membrane translocator Smed_5335 107 COG4603 COG4603, ABC-type uncharacterized transport system, permease component General function prediction only 150377814 Common - Tetratricopeptide TPR_2 repeat protein Smed_5770 74 COG0457 NrfG, FOG: TPR repeat General function prediction only 150377279 Common - ABC transporter related Smed_5164 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377564 Common - NADH:flavin oxidoreductase/NADH oxidase Smed_5465 177 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 150378169 Common - Electron transfer flavoprotein alpha/beta-subunit Smed_6228 152 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 150377882 Common - Alcohol dehydrogenase zinc-binding domain protein Smed_5850 179 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 150378258 Common - cytochrome c class I Smed_6323 57 COG3474 COG3474, Cytochrome c2 Energy production and conversion 150378104 Common - transcriptional regulator, XRE family Smed_6134 33 COG1396 HipB, Predicted transcriptional regulators Transcription 150378020 Common - transcriptional regulator, XRE family Smed_6009 116 COG1396 HipB, Predicted transcriptional regulators Transcription 150377796 Common - Enoyl-CoA hydratase/isomerase Smed_5746 182 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 150378176 Common - NifT/FixU family protein Smed_6235 17 COG5554 NifU, Nitrogen fixation protein Secondary metabolites biosynthesis, transport, and catabolism 150377628 Common - response regulator receiver protein Smed_5540 209 COG4566 TtrR, Response regulator Signal transduction mechanisms 150378096 Nonpathogen - hypothetical protein Smed_6124 1 None None None 150378122 Common - putative virB5 gene Smed_6158 3 None None None 150378044 Nonpathogen - hypothetical protein Smed_6052 2 None None None 150377611 Common - response regulator receiver protein Smed_5521 209 COG4566 TtrR, Response regulator Signal transduction mechanisms 150377479 Nonpathogen - hypothetical protein Smed_5371 1 None None None 150378248 Common - ABC transporter, periplasmic solute-binding protein Smed_6313 53 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 150377349 Common - Citrate transporter Smed_5235 133 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 150377434 Common - diguanylate cyclase Smed_5323 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 150377470 Common - osmosensitive K+ channel signal transduction histidine kinase Smed_5361 218 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 150377327 Common - hypothetical protein Smed_5212 3 None None None 150377237 Common - type II secretion system protein E Smed_5122 161 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 150378205 Common - cytochrome c oxidase, cbb3-type, subunit I Smed_6268 122 COG3278 CcoN, Cbb3-type cytochrome oxidase, subunit 1 Posttranslational modification, protein turnover, chaperones 150377913 Common - polar amino acid ABC transporter, inner membrane subunit Smed_5881 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 150377752 Nonpathogen - hypothetical protein Smed_5689 1 None None None 150378000 Common - hypothetical protein Smed_5987 14 None None None 150378029 Common - oxidoreductase molybdopterin binding Smed_6027 95 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 150378071 Common - yecA family protein Smed_6093 11 COG3318 COG3318, Predicted metal-binding protein related to the C-terminal domain of SecA General function prediction only 150378007 Nonpathogen - hypothetical protein Smed_5994 1 None None None 150378232 Common - UbiD family decarboxylase Smed_6296 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 150377703 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Smed_5623 249 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 150377199 Common - GntR domain protein Smed_5082 133 COG2186 FadR, Transcriptional regulators Transcription 150377852 Nonpathogen - hypothetical protein Smed_5818 1 None None None 150377342 Common - Pirin domain protein Smed_5228 140 COG1741 COG1741, Pirin-related protein General function prediction only 150377239 Nonpathogen - TadE family protein Smed_5124 4 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 150377390 Common - Xanthine/uracil/vitamin C permease Smed_5276 138 COG2252 COG2252, Permeases General function prediction only 150377904 Common - transcriptional regulator, GntR family Smed_5872 117 COG1802 GntR, Transcriptional regulators Transcription 150377220 Common - glycine betaine/L-proline ABC transporter, ATPase subunit Smed_5105 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 150378027 Common - Transposase and inactivated derivatives-like protein Smed_6023 54 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377943 Common - alpha,alpha-trehalose-phosphate synthase (UDP-forming) Smed_5911 96 COG0380 OtsA, Trehalose-6-phosphate synthase Carbohydrate transport and metabolism 150378164 Common - nitrogenase MoFe cofactor biosynthesis protein NifE Smed_6222 58 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 150377872 Common - hypothetical protein Smed_5839 8 None None None 150377746 Common - HipA domain protein Smed_5679 54 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 150377839 Common - gluconate 5-dehydrogenase Smed_5798 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 150377210 Common - beta-ketoadipyl CoA thiolase Smed_5094 176 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 150378242 Nonpathogen - hypothetical protein Smed_6307 4 None None None 150377965 Common - cytochrome c oxidase, cbb3-type, subunit I Smed_5935 122 COG3278 CcoN, Cbb3-type cytochrome oxidase, subunit 1 Posttranslational modification, protein turnover, chaperones 150378017 Common - ferredoxin-dependent glutamate synthase Smed_6006 170 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 150377369 Common - protein of unknown function DUF159 Smed_5255 39 COG2135 COG2135, Uncharacterized conserved protein Function unknown 150377504 Common - WGR domain protein Smed_5398 5 COG3831 COG3831, Uncharacterized conserved protein Function unknown 150377562 Common - FAD dependent oxidoreductase Smed_5463 139 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 150377577 Common - formate dehydrogenase family accessory protein FdhD Smed_5485 136 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 150377654 Common - transcriptional regulator, LysR family Smed_5569 155 COG0583 LysR, Transcriptional regulator Transcription 150377389 Common - Adenine deaminase Smed_5275 78 COG1001 AdeC, Adenine deaminase Nucleotide transport and metabolism 150377830 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Smed_5788 249 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 150377975 Common - protein of unknown function DUF470 Smed_5951 79 COG2898 COG2898, Uncharacterized conserved protein Function unknown 150377588 Nonpathogen - hypothetical protein Smed_5496 10 None None None 150377687 Common - acetylornithine deacetylase Smed_5605 203 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 150377464 Common - aldehyde oxidase and xanthine dehydrogenase molybdopterin binding Smed_5354 110 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 150377857 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Smed_5824 177 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 150377957 Common - cyclic nucleotide-binding protein Smed_5927 71 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 150377770 Common - transcriptional regulator, MarR family Smed_5709 90 COG1846 MarR, Transcriptional regulators Transcription 150377195 Common - binding-protein-dependent transport systems inner membrane component Smed_5078 221 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377664 Common - binding-protein-dependent transport systems inner membrane component Smed_5580 142 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 150377895 Common - ABC transporter related Smed_5863 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 150377609 Nonpathogen - hypothetical protein Smed_5518 4 None None None 150377594 Common - DNA binding domain, excisionase family Smed_5502 62 COG1910 COG1910, Periplasmic molybdate-binding protein/domain Inorganic ion transport and metabolism 150377418 Nonpathogen - hypothetical protein Smed_5306 1 None None None 150377574 Common - histidinol-phosphate phosphatase, putative Smed_5476 196 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 150377936 Common - Dimethylmenaquinone methyltransferase Smed_5904 57 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 150377777 Nonpathogen - hypothetical protein Smed_5718 1 None None None 150377409 Common - short chain dehydrogenase Smed_5297 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 150377203 Common - LAO/AO transport system ATPase Smed_5087 99 COG1703 ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family Amino acid transport and metabolism 150377292 Common - periplasmic nitrate reductase NapE Smed_5177 10 COG4459 NapE, Periplasmic nitrate reductase system, NapE component Energy production and conversion 150377266 Common - transposase IS4 family protein Smed_5151 28 None None None 150377217 Common - Mandelate racemase/muconate lactonizing protein Smed_5102 132 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 150377520 Common - transcriptional regulator, XRE family Smed_5417 37 COG1476 COG1476, Predicted transcriptional regulators Transcription 150377897 Common - GntR domain protein Smed_5865 124 COG2186 FadR, Transcriptional regulators Transcription 150377386 Common - transcriptional regulator, LysR family Smed_5272 166 COG0583 LysR, Transcriptional regulator Transcription 150377697 Nonpathogen - hypothetical protein Smed_5616 2 None None None 150377256 Nonpathogen - hypothetical protein Smed_5141 1 None None None 150377690 Common - high-affinity nickel-transporter Smed_5609 43 COG2215 COG2215, ABC-type uncharacterized transport system, permease component General function prediction only 150378136 Common - nitrogenase molybdenum-iron cofactor biosynthesis protein NifN Smed_6181 48 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 150377308 Common - extracellular solute-binding protein family 3 Smed_5193 81 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 150377522 Common - hypothetical protein Smed_5419 20 None None None 150378219 Common - hypothetical protein Smed_6283 25 COG4309 COG4309, Uncharacterized conserved protein Function unknown 150377497 Common - TraB family protein Smed_5391 6 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 150377377 Common - ABC transporter related Smed_5263 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 150377754 Common - sterile alpha motif SAM protein Smed_5691 98 COG3899 COG3899, Predicted ATPase General function prediction only 150378063 Nonpathogen - conserved hypothetical exopeptide protein Smed_6080 1 None None None 150377428 Common - inner-membrane translocator Smed_5317 126 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 150377618 Common - Epoxide hydrolase domain protein Smed_5530 37 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 150377486 Common - type IV secretion/conjugal transfer ATPase, VirB4 family Smed_5379 60 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 150377459 Common - glutamine synthetase catalytic region Smed_5349 222 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 150377280 Common - binding-protein-dependent transport systems inner membrane component Smed_5165 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377926 Common - FAD dependent oxidoreductase Smed_5894 107 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 150377844 Common - HipA domain protein Smed_5805 60 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 150377402 Common - protein of unknown function DUF6 transmembrane Smed_5288 156 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 150377175 Common - bifunctional deaminase-reductase domain protein Smed_5058 32 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 150378256 Nonpathogen - hypothetical protein Smed_6321 5 None None None 150378202 Common - cytochrome c oxidase, cbb3-type, subunit III Smed_6265 82 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 150378225 Common - cytochrome c class I Smed_6289 37 None None None 150377737 Nonpathogen - hypothetical protein Smed_5669 1 None None None 150377730 Common - aldo/keto reductase Smed_5659 199 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 150378166 Common - nitrogenase molybdenum-iron protein alpha chain Smed_6224 50 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 150378042 Nonpathogen - hypothetical protein Smed_6049 1 None None None 150377396 Common - transcriptional regulator, LysR family Smed_5282 86 COG0583 LysR, Transcriptional regulator Transcription 150378002 Common - Xylose isomerase domain protein TIM barrel Smed_5989 65 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 150377625 Common - short-chain dehydrogenase/reductase SDR Smed_5537 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 150377571 Common - regulatory protein IclR Smed_5473 120 COG1414 IclR, Transcriptional regulator Transcription 150378239 Common - hypothetical protein Smed_6304 5 None None None 150377798 Common - Formyl-CoA transferase Smed_5748 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 150377374 Common - Alcohol dehydrogenase Smed_5260 171 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 150377329 Common - hypothetical protein Smed_5214 6 None None None 150377596 Common - ABC transporter related Smed_5504 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 150377701 Common - binding-protein-dependent transport systems inner membrane component Smed_5621 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150378129 Common - Transposase and inactivated derivatives-like protein Smed_6167 75 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 150378230 Common - NnrUfamily protein Smed_6294 17 COG4094 COG4094, Predicted membrane protein Function unknown 150377469 Common - potassium-transporting ATPase, C subunit Smed_5360 94 COG2156 KdpC, K+-transporting ATPase, c chain Inorganic ion transport and metabolism 150377646 Common - Hydroxypyruvate isomerase Smed_5560 83 COG3622 Hfi, Hydroxypyruvate isomerase Carbohydrate transport and metabolism 150377183 Common - binding-protein-dependent transport systems inner membrane component Smed_5066 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377717 Common - hypothetical protein Smed_5646 13 COG1100 COG1100, GTPase SAR1 and related small G proteins General function prediction only 150378089 Nonpathogen - hypothetical protein Smed_6112 1 None None None 150377234 Common - response regulator receiver modulated CheB methylesterase Smed_5119 151 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 150377431 Common - putative ABC transporter Smed_5320 43 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 150377351 Common - AbgT putative transporter Smed_5237 39 COG2978 AbgT, Putative p-aminobenzoyl-glutamate transporter Coenzyme metabolism 150377322 Common - hypothetical protein Smed_5207 3 None None None 150377200 Common - major facilitator superfamily MFS_1 Smed_5083 129 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 150377603 Common - transposase IS66 Smed_5512 58 None None None 150377676 Common - extracellular solute-binding protein family 5 Smed_5594 184 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 150378135 Common - acriflavin resistance protein Smed_6179 178 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 150377940 Common - Malate/L-lactate dehydrogenase Smed_5908 67 COG2055 COG2055, Malate/L-lactate dehydrogenases Energy production and conversion 150377364 Nonpathogen - hypothetical protein Smed_5250 1 None None None 150377505 Common - protein of unknown function DUF736 Smed_5399 26 COG5489 COG5489, Uncharacterized conserved protein Function unknown 150378031 Common - two component transcriptional regulator, winged helix family Smed_6029 221 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 150377243 Nonpathogen - hypothetical protein Smed_5128 9 COG4655 COG4655, Predicted membrane protein Function unknown 150377800 Common - hypothetical protein Smed_5750 18 None None None 150378036 Common - cytochrome B561 Smed_6037 28 COG3658 COG3658, Cytochrome b Energy production and conversion 150377724 Common - Acyl-CoA dehydrogenase type 2 domain Smed_5653 141 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 150377581 Common - formate dehydrogenase, gamma subunit Smed_5489 68 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 150377545 Common - Transposase and inactivated derivatives-like protein Smed_5445 44 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 150378156 Nonpathogen - hypothetical protein Smed_6209 1 None None None 150378023 Nonpathogen - hypothetical protein Smed_6018 1 None None None 150377447 Common - Amidase Smed_5337 206 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 150377706 Common - hypothetical protein Smed_5626 20 None None None 150378185 Common - binding-protein-dependent transport systems inner membrane component Smed_6248 152 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 150377494 Common - Autoinducer-binding domain protein Smed_5387 46 COG2771 CsgD, DNA-binding HTH domain-containing proteins Transcription 150377578 Common mobA molybdopterin-guanine dinucleotide biosynthesis protein A Smed_5486 82 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 150377229 Common - two component transcriptional regulator, LuxR family Smed_5114 177 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 150377809 Nonpathogen - hypothetical protein Smed_5763 3 None None None 150377331 Common - short-chain dehydrogenase/reductase SDR Smed_5216 237 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 150377683 Common - 3-isopropylmalate dehydrogenase Smed_5601 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 150377222 Common - isochorismatase hydrolase Smed_5107 81 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 150378124 Common - type IV secretory pathway VirB3 family protein Smed_6160 12 COG3702 VirB3, Type IV secretory pathway, VirB3 components Intracellular trafficking and secretion 150377789 Nonpathogen - hypothetical protein Smed_5739 2 None None None 150377902 Common - ferredoxin Smed_5870 130 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 150377534 Common - hypothetical protein Smed_5433 6 None None None 150377886 Common - Cupin 2 conserved barrel domain protein Smed_5854 12 COG2140 COG2140, Thermophilic glucose-6-phosphate isomerase and related metalloenzymes Carbohydrate transport and metabolism / General function prediction only 150377566 Common - FAD linked oxidase domain protein Smed_5468 201 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 150377984 Common - transcriptional regulator, CopG family Smed_5961 11 COG3905 COG3905, Predicted transcriptional regulator Transcription 150377477 Common - transcriptional regulator, LysR family Smed_5369 149 COG0583 LysR, Transcriptional regulator Transcription 150377384 Common - DNA polymerase III subunit epsilon Smed_5270 75 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 150377669 Nonpathogen - hypothetical protein Smed_5585 1 None None None 150377316 Common - hypothetical protein Smed_5201 30 COG4371 COG4371, Predicted membrane protein Function unknown 150377685 Common - protein of unknown function DUF861 cupin_3 Smed_5603 28 COG3450 COG3450, Predicted enzyme of the cupin superfamily General function prediction only 150378220 Common - hypothetical protein Smed_6284 24 COG1432 COG1432, Uncharacterized conserved protein Function unknown 150377276 Nonpathogen - hypothetical protein Smed_5161 2 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 150377916 Common - Methyltransferase type 11 Smed_5884 156 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 150377373 Common - aldehyde dehydrogenase Smed_5259 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 150377408 Common - regulatory protein ArsR Smed_5296 60 COG0640 ArsR, Predicted transcriptional regulators Transcription 150377241 Common - SAF domain protein Smed_5126 51 COG3745 CpaB, Flp pilus assembly protein CpaB Intracellular trafficking and secretion 150378227 Common - cytochrome c oxidase subunit III Smed_6291 73 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 150378051 Common - NUDIX hydrolase Smed_6062 29 COG4119 COG4119, Predicted NTP pyrophosphohydrolase DNA replication, recombination, and repair / General function prediction only 150378207 Common fixK transcriptional regulator FixK Smed_6270 143 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 150377248 Common - transcriptional regulator, GntR family Smed_5133 130 COG1802 GntR, Transcriptional regulators Transcription 150377810 Common - Glycerol uptake facilitator and related permease (Major Intrinsic Protein Family)-like protein Smed_5764 92 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 150377507 Common - sulphate transporter Smed_5404 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 150377946 Common - hypothetical protein Smed_5915 6 None None None 150377356 Common - Monosaccharide-transporting ATPase Smed_5242 99 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 150377635 Nonpathogen - hypothetical protein Smed_5549 1 None None None 150377610 Common - Epoxide hydrolase domain protein Smed_5519 39 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 150377930 Nonpathogen - hypothetical protein Smed_5898 1 None None None 150378099 Nonpathogen - hypothetical protein Smed_6128 1 None None None 150378178 Common - transposase IS116/IS110/IS902 family protein Smed_6239 76 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377651 Common - OsmC family protein Smed_5565 88 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 150378110 Nonpathogen - hypothetical protein Smed_6142 2 None None None 150377935 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Smed_5903 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 150377516 Common - ABC transporter related Smed_5413 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 150377269 Common - protein of unknown function UPF0118 Smed_5154 167 COG0628 PerM, Predicted permease General function prediction only 150377558 Common - ABC transporter related Smed_5459 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 150378084 Common - TfuA domain protein core Smed_6107 25 COG3482 COG3482, Uncharacterized conserved protein Function unknown 150377454 Common - ABC transporter related Smed_5344 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 150377658 Common - methionine sulfoxide reductase B Smed_5573 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 150377924 Common - short-chain dehydrogenase/reductase SDR Smed_5892 237 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 150377528 Nonpathogen - hypothetical protein Smed_5425 1 None None None 150378215 Common - NnrS family protein Smed_6279 57 COG3213 NnrS, Uncharacterized protein involved in response to NO Inorganic ion transport and metabolism 150377181 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Smed_5064 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 150378253 Common - transcriptional regulator, LysR family Smed_6318 193 COG0583 LysR, Transcriptional regulator Transcription 150377782 Common - Methyltransferase type 11 Smed_5724 24 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 150377765 Common - TRAP dicarboxylate transporter, DctM subunit Smed_5703 122 COG1593 DctQ, TRAP-type C4-dicarboxylate transport system, large permease component Carbohydrate transport and metabolism 150377825 Common - response regulator receiver protein Smed_5781 44 COG4566 TtrR, Response regulator Signal transduction mechanisms 150378090 Common - Transposase and inactivated derivatives-like protein Smed_6113 44 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377565 Nonpathogen - hypothetical protein Smed_5466 1 None None None 150377954 Nonpathogen - Cbb3-type cytochrome oxidase component Smed_5924 5 COG4736 CcoQ, Cbb3-type cytochrome oxidase, subunit 3 Posttranslational modification, protein turnover, chaperones 150377981 Common - protein of unknown function DUF1003 Smed_5958 36 COG4420 COG4420, Predicted membrane protein Function unknown 150377662 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Smed_5578 24 COG3871 COG3871, Uncharacterized stress protein (general stress protein 26) General function prediction only 150378142 Common - nodulation ABC transporter NodI Smed_6187 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 150378149 Common - NodH sulfotransferase Smed_6196 3 COG4424 COG4424, Uncharacterized protein conserved in bacteria Function unknown 150377988 Common - Helix-turn-helix type 11 domain protein Smed_5970 87 COG2378 COG2378, Predicted transcriptional regulator Transcription 150377893 Nonpathogen - hypothetical protein Smed_5861 1 None None None 150377282 Common - 4-phytase Smed_5167 208 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 150377877 Common - Mandelate racemase/muconate lactonizing protein Smed_5845 111 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 150377850 Common - NADP oxidoreductase coenzyme F420-dependent Smed_5816 50 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 150378244 Common - Alcohol dehydrogenase GroES domain protein Smed_6309 202 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 150377831 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Smed_5789 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377207 Common - beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family Smed_5091 116 COG1414 IclR, Transcriptional regulator Transcription 150377412 Nonpathogen - hypothetical protein Smed_5300 3 None None None 150377775 Nonpathogen - hypothetical protein Smed_5716 1 None None None 150377605 Common - transposase IS66 Smed_5514 53 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377169 Common - Transposase and inactivated derivatives-like protein Smed_5052 44 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377336 Common - DoxX family protein Smed_5222 66 COG2259 COG2259, Predicted membrane protein Function unknown 150378028 Common - transcriptional regulator, MucR family Smed_6025 34 COG4957 COG4957, Predicted transcriptional regulator Transcription 150378109 Common - aldehyde dehydrogenase Smed_6141 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 150377254 Common - transcription elongation factor regulatory protein Smed_5139 153 COG0782 GreA, Transcription elongation factor Transcription 150377748 Nonpathogen - glycosyl transferase group 1 Smed_5684 4 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 150377306 Nonpathogen - hypothetical protein Smed_5191 3 None None None 150377295 Common - periplasmic nitrate reductase, large subunit Smed_5180 185 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 150377719 Common - putative nitrilotriacetate monooxygenase component A Smed_5648 68 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 150378217 Common - hypothetical protein Smed_6281 13 None None None 150377855 Common - Cupin 2 conserved barrel domain protein Smed_5822 20 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 150378195 Common - Transposase and inactivated derivatives-like protein Smed_6258 44 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 150378025 Nonpathogen - hypothetical protein Smed_6021 1 None None None 150377644 Common - binding-protein-dependent transport systems inner membrane component Smed_5558 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377674 Common - binding-protein-dependent transport systems inner membrane component Smed_5592 218 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377805 Common - signal transduction histidine kinase Smed_5756 39 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 150377792 Common - signal transduction histidine kinase Smed_5742 42 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 150377582 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Smed_5490 169 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 150377552 Common - hypothetical protein Smed_5453 24 COG5340 COG5340, Predicted transcriptional regulator Transcription 150377213 Common - helix-turn-helix- domain containing protein AraC type Smed_5098 71 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 150377232 Common - methyl-accepting chemotaxis sensory transducer Smed_5117 157 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 150378087 Nonpathogen - hypothetical protein Smed_6110 1 None None None 150377692 Common - major facilitator superfamily MFS_1 Smed_5611 29 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 150377460 Common - methionine sulfoxide reductase B Smed_5350 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 150377959 Common - copper-translocating P-type ATPase Smed_5929 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 150377699 Common - extracellular solute-binding protein family 5 Smed_5619 187 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 150378255 Common - two component transcriptional regulator, winged helix family Smed_6320 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 150377286 Common - aminotransferase class IV Smed_5171 153 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 150377795 Common - Monosaccharide-transporting ATPase Smed_5745 128 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 150377475 Nonpathogen - hypothetical protein Smed_5366 1 None None None 150378049 Common - amino acid carrier protein Smed_6060 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 150377568 Common - spermidine/putrescine ABC transporter ATPase subunit Smed_5470 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 150377297 Common - periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family Smed_5182 47 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 150378100 Common - Monophenol monooxygenase Smed_6129 19 None None None 150377532 Common - phage integrase family protein Smed_5431 49 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 150378168 Nonpathogen - hypothetical protein Smed_6226 1 None None None 150377868 Common - putative ABC transporter, periplasmic solute-binding protein Smed_5835 70 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 150377763 Common - TRAP dicarboxylate transporter- DctP subunit Smed_5701 94 COG1638 DctP, TRAP-type C4-dicarboxylate transport system, periplasmic component Carbohydrate transport and metabolism 150378075 Common - transposase IS66 Smed_6097 52 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377623 Common - Enoyl-CoA hydratase/isomerase Smed_5535 122 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 150377732 Common - Acyl-CoA dehydrogenase type 2 domain Smed_5663 37 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 150377561 Common - sugar isomerase (SIS) Smed_5462 33 COG2222 AgaS, Predicted phosphosugar isomerases Cell envelope biogenesis, outer membrane 150377768 Common - Lysine exporter protein (LYSE/YGGA) Smed_5706 35 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 150378160 Nonpathogen - SyrA protein involved in EPS production Smed_6217 1 None None None 150378004 Common - beta-lactamase domain protein Smed_5991 29 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 150377715 Common - protein of unknown function DUF1214 Smed_5642 42 COG5361 COG5361, Uncharacterized conserved protein Function unknown 150377629 Nonpathogen - hypothetical protein Smed_5541 1 None None None 150377473 Common - HPP family protein? Smed_5364 82 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 150377302 Common - protein of unknown function UPF0118 Smed_5187 71 COG0628 PerM, Predicted permease General function prediction only 150377452 Common - inner-membrane translocator Smed_5342 160 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 150378120 Common - T-DNA transfer lipoprotein (virB7) Smed_6156 3 None None None 150377900 Common - Xylose isomerase domain protein TIM barrel Smed_5868 70 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 150377399 Common - cation transporter Smed_5285 131 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 150377973 Common - transcriptional regulator, LysR family Smed_5948 102 COG0583 LysR, Transcriptional regulator Transcription 150377318 Common - ornithine carbamoyltransferase Smed_5203 239 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 150378137 Nonpathogen - hypothetical protein Smed_6182 1 None None None 150377426 Nonpathogen - hypothetical protein Smed_5314 1 None None None 150377820 Common - putative PAS/PAC sensor protein Smed_5776 182 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 150377807 Common - alpha/beta hydrolase fold Smed_5761 103 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 150377982 Nonpathogen - hypothetical protein Smed_5959 1 None None None 150377681 Common - FAD dependent oxidoreductase Smed_5599 120 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 150377416 Common - hypothetical protein Smed_5304 7 None None None 150377728 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Smed_5657 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 150378130 Common - Transposase and inactivated derivatives-like protein Smed_6168 75 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377891 Common - binding-protein-dependent transport systems inner membrane component Smed_5859 145 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 150377739 Common - putative plasmid stability protein Smed_5671 25 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 150377485 Common - Conjugal transfer TrbD family protein Smed_5378 15 COG5268 TrbD, Type IV secretory pathway, TrbD component Cell motility and secretion / Intracellular trafficking and secretion 150377440 Common - transcriptional regulator, TetR family Smed_5330 77 COG1309 AcrR, Transcriptional regulator Transcription 150377726 Common - binding-protein-dependent transport systems inner membrane component Smed_5655 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150377543 Nonpathogen - hypothetical protein Smed_5443 5 None None None 150377818 Common - peptidase S8 and S53 subtilisin kexin sedolisin Smed_5774 120 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 150378038 Common - K potassium transporter Smed_6041 88 COG3158 Kup, K+ transporter Inorganic ion transport and metabolism 150377449 Common - aminotransferase class-III Smed_5339 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 150377704 Common - Integrase catalytic region Smed_5624 85 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377937 Common - Uncharacterized protein UPF0065 Smed_5905 70 COG3181 COG3181, Uncharacterized protein conserved in bacteria Function unknown 150377616 Common - transcriptional regulator, LysR family Smed_5526 124 COG0583 LysR, Transcriptional regulator Transcription 150377759 Common - transcriptional regulator, TetR family Smed_5697 97 COG1309 AcrR, Transcriptional regulator Transcription 150378092 Common - Transposase and inactivated derivatives-like protein Smed_6118 75 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 150377922 Common mtnA methylthioribose-1-phosphate isomerase Smed_5890 130 COG0182 COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 150377483 Common - P-type conjugative transfer ATPase TrbB Smed_5376 177 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 150377879 Common - hypothetical protein Smed_5847 2 None None None 150377526 Common - hypothetical protein Smed_5423 14 COG5642 COG5642, Uncharacterized conserved protein Function unknown 150378059 Nonpathogen - hypothetical protein Smed_6072 1 None None None 150377511 Common - phage integrase family protein Smed_5408 216 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 150378172 Common - FixX ferredoxin-like protein Smed_6231 36 COG2440 FixX, Ferredoxin-like protein Energy production and conversion 150377694 Nonpathogen - hypothetical protein Smed_5613 1 None None None 150378082 Nonpathogen - hypothetical protein Smed_6105 1 COG5285 COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin Secondary metabolites biosynthesis, transport, and catabolism 150377909 Common - Streptomycin 3''-adenylyltransferase Smed_5877 22 COG1708 COG1708, Predicted nucleotidyltransferases General function prediction only 150377551 Common - hypothetical protein Smed_5452 2 None None None 150377853 Common - beta-lactamase domain protein Smed_5820 79 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 150378068 Common - peptidase C1A papain Smed_6088 22 COG4870 COG4870, Cysteine protease Posttranslational modification, protein turnover, chaperones 150377260 Nonpathogen - hypothetical protein Smed_5145 10 None None None 150377548 Common - adenylyl cyclase class-3/4/guanylyl cyclase Smed_5448 62 COG5616 COG5616, Predicted integral membrane protein Function unknown 150377780 Common - transcriptional regulator, LysR family Smed_5722 130 COG0583 LysR, Transcriptional regulator Transcription 150377170 Common - Arsenate resistance ArsH Smed_5053 63 COG0431 COG0431, Predicted flavoprotein General function prediction only 150377667 Common - Alpha-N-arabinofuranosidase Smed_5583 31 COG3534 AbfA, Alpha-L-arabinofuranosidase Carbohydrate transport and metabolism 150378222 Common - von Willebrand factor type A Smed_6286 48 COG4548 NorD, Nitric oxide reductase activation protein Inorganic ion transport and metabolism 150377424 Common - Serine--pyruvate transaminase Smed_5312 155 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 150377966 Nonpathogen - response regulator receiver protein Smed_5937 1 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 150377750 Common - glycosyl transferase group 1 Smed_5686 209 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 150378229 Nonpathogen - hypothetical protein Smed_6293 2 None None None 150377333 Common - protein of unknown function DUF1330 Smed_5218 12 COG5470 COG5470, Uncharacterized conserved protein Function unknown 150378158 Common - transcriptional regulator, LysR family Smed_6212 88 COG0583 LysR, Transcriptional regulator Transcription 150377278 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Smed_5163 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 150377812 Common - sulfatase Smed_5768 78 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 150377948 Nonpathogen - putative transmembrane protein Smed_5918 1 None None None 150377371 Common - Glutathione S-transferase domain Smed_5257 73 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 150377918 Common - periplasmic binding protein/LacI transcriptional regulator Smed_5886 80 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 150377633 Common - alpha/beta hydrolase fold Smed_5546 95 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 150377205 Common - aminotransferase class-III Smed_5089 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 150378187 Common - NIPSNAP family containing protein Smed_6250 19 None None None 150377284 Common - transcriptional regulator, LysR family Smed_5169 155 COG0583 LysR, Transcriptional regulator Transcription 150377414 Nonpathogen - hypothetical protein Smed_5302 1 None None None 150378194 Common - transcriptional regulator, GntR family Smed_6257 139 COG1802 GntR, Transcriptional regulators Transcription 150378118 Common - P-type conjugative transfer protein VirB9 Smed_6154 40 COG3504 VirB9, Type IV secretory pathway, VirB9 components Intracellular trafficking and secretion 150377598 Common - molybdopterin binding domain Smed_5506 161 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 150377833 Common - cytosine deaminase Smed_5791 71 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 150377190 Common - FAD dependent oxidoreductase Smed_5073 100 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 150378246 Common - binding-protein-dependent transport systems inner membrane component Smed_6311 226 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 150377311 Common - Lysine decarboxylase Smed_5196 87 COG1982 LdcC, Arginine/lysine/ornithine decarboxylases Amino acid transport and metabolism 150378018 Common - glutamate synthase alpha subunit domain protein Smed_6007 61 COG0070 GltB, Glutamate synthase domain 3 Amino acid transport and metabolism 150377438 Common - ABC transporter related Smed_5328 247 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 150377608 Common - isochorismatase hydrolase Smed_5517 112 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 150377394 Common - 3-demethylubiquinone-9 3-methyltransferase Smed_5280 60 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 150377518 Common - binding-protein-dependent transport systems inner membrane component Smed_5415 220 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150378078 Common - Methyltransferase type 11 Smed_6101 23 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 150378013 Common - Integrase catalytic region Smed_6000 14 None None None 150378011 Common - NUDIX hydrolase Smed_5998 29 COG4119 COG4119, Predicted NTP pyrophosphohydrolase DNA replication, recombination, and repair / General function prediction only 150377998 Common - Glucan 1,4-alpha-glucosidase Smed_5985 5 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 150378033 Common - sulfatase Smed_6033 63 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 150378125 Common - VIRB2 type IV secretion fmaily protein Smed_6161 6 COG3838 VirB2, Type IV secretory pathway, VirB2 components (pilins) Intracellular trafficking and secretion 150377827 Common - Asp/Glu racemase Smed_5785 46 COG4126 COG4126, Hydantoin racemase Amino acid transport and metabolism 150377406 Common - Glutathione S-transferase domain Smed_5294 73 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 150377338 Common - protein of unknown function DUF1486 Smed_5224 23 COG5485 COG5485, Predicted ester cyclase General function prediction only 150377970 Common - transcriptional regulator, LysR family Smed_5941 91 COG0583 LysR, Transcriptional regulator Transcription 150377442 Common - major facilitator superfamily MFS_1 Smed_5332 170 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 150377961 Common - Cytochrome c oxidase cbb3 type accessory protein FixG Smed_5931 77 COG0348 NapH, Polyferredoxin Energy production and conversion 150377952 Nonpathogen - hypothetical protein Smed_5922 1 None None None 150377304 Common - secretion protein HlyD family protein Smed_5189 97 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 150377741 Nonpathogen - conserved hypothetical 21.7 KDA protein in syrb 5'region (ORF4) Smed_5674 2 None None None 150377188 Common - BFD domain protein (2Fe-2S)-binding domain protein Smed_5071 28 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 150377994 Common - Rieske (2Fe-2S) domain protein Smed_5979 83 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 150377660 Common - histidine kinase Smed_5576 139 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 150378148 Nonpathogen - NodF acyl carrier protein Smed_6195 3 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 150377344 Common - beta-lactamase domain protein Smed_5230 75 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 150377932 Common - Rhodanese domain protein Smed_5900 141 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 150378131 Nonpathogen - hypothetical protein Smed_6170 1 None None None 150377245 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Smed_5130 4 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 150377787 Common - GCN5-related N-acetyltransferase Smed_5733 87 COG0456 RimI, Acetyltransferases General function prediction only 150377841 Common - hypothetical protein Smed_5801 11 None None None