Shewanella loihica PV-4, complete genome NC_009092 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 127512952 Common - cell divisionFtsK/SpoIIIE Shew_2024 199 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 127513194 Common - (2Fe-2S)-binding domain protein Shew_2266 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 127511892 Common - hypothetical protein Shew_0959 19 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 127512993 Common - diguanylate cyclase/phosphodiesterase Shew_2065 161 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 127512008 Common - cytochrome c, class II Shew_1075 36 COG3909 COG3909, Cytochrome c556 Energy production and conversion 127513342 Common - ATP-NAD/AcoX kinase Shew_2414 26 COG3199 COG3199, Uncharacterized conserved protein Function unknown 127511014 Common - integral membrane sensor signal transduction histidine kinase Shew_0080 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127510960 Common - Protoporphyrinogen oxidase Shew_0025 33 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 127512445 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Shew_1516 226 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 127513935 Common - transcriptional regulator, LysR family Shew_3007 163 COG0583 LysR, Transcriptional regulator Transcription 127511842 Common - hypothetical protein Shew_0909 6 None None None 127512454 Common - Biopolymer transport protein ExbD/TolR Shew_1525 141 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 127511830 Common - hypothetical protein Shew_0897 2 None None None 127512386 Common - response regulator receiver modulated CheW protein Shew_1457 164 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 127511203 Common - protein of unknown function DUF1223 Shew_0269 33 COG5429 COG5429, Uncharacterized secreted protein Function unknown 127514299 Nonpathogen - hypothetical protein Shew_3371 1 None None None 127513095 Common - hypothetical protein Shew_2167 29 None None None 127513405 Common - MotA/TolQ/ExbB proton channel Shew_2477 134 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 127513646 Common - TonB-dependent receptor Shew_2718 96 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 127513051 Common - putative sulfite oxidase subunit YedY Shew_2123 89 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 127514147 Common - transcriptional regulator, LysR family Shew_3219 180 COG0583 LysR, Transcriptional regulator Transcription 127514553 Common - sodium:dicarboxylate symporter Shew_3625 163 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 127514268 Common - TonB-dependent receptor Shew_3340 63 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 127511019 Common - methyl-accepting chemotaxis sensory transducer Shew_0085 151 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127512534 Common - beta-ketoacyl synthase Shew_1605 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127512440 Common - UMP phosphatase Shew_1511 98 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 127513857 Common leuS leucyl-tRNA synthetase Shew_2929 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 127514046 Common - hypothetical protein Shew_3118 84 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 127512019 Common - Hemerythrin HHE cation binding domain protein Shew_1086 14 COG3945 COG3945, Uncharacterized conserved protein Function unknown 127511699 Common - acriflavin resistance protein Shew_0765 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 127511969 Common - putative adenylate/guanylate cyclase Shew_1036 7 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 127512916 Common - cytochrome c oxidase, cbb3-type, subunit III Shew_1988 81 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 127512613 Common - Lysine exporter protein (LYSE/YGGA) Shew_1684 74 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 127514066 Nonpathogen - hypothetical protein Shew_3138 1 None None None 127513687 Common - peptidase S9, prolyl oligopeptidase active site domain protein Shew_2759 103 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 127513652 Common - Indigoidine synthase A family protein Shew_2724 49 COG2313 IndA, Uncharacterized enzyme involved in pigment biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 127513256 Common - signal transduction histidine kinase, LytS Shew_2328 105 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 127512623 Nonpathogen - hypothetical protein Shew_1694 1 None None None 127512765 Common - hypothetical protein Shew_1837 19 COG3249 COG3249, Uncharacterized protein conserved in bacteria Function unknown 127512791 Common - arsenate reductase and related Shew_1863 106 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 127514491 Common - hypothetical protein Shew_3563 2 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 127513146 Common - signal transduction histidine kinase regulating citrate/malate metabolism Shew_2218 62 COG3290 CitA, Signal transduction histidine kinase regulating citrate/malate metabolism Signal transduction mechanisms 127513093 Common - Aldose 1-epimerase Shew_2165 58 COG0676 COG0676, Uncharacterized enzymes related to aldose 1-epimerase Carbohydrate transport and metabolism 127514101 Common - succinic semialdehyde dehydrogenase Shew_3173 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 127511446 Common - ABC transporter-related protein Shew_0512 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 127514775 Common - ATP synthase F0, C subunit Shew_3850 74 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 127511939 Common - ErfK/YbiS/YcfS/YnhG family protein Shew_1006 86 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 127513969 Nonpathogen - hypothetical protein Shew_3041 1 None None None 127512473 Common - transcriptional regulator, TetR family Shew_1544 101 COG1309 AcrR, Transcriptional regulator Transcription 127512858 Common - CopG domain protein DNA-binding domain protein Shew_1930 9 None None None 127514596 Common - conserved hypothetical protein 698 Shew_3668 112 COG2855 COG2855, Predicted membrane protein Function unknown 127512398 Common - hypothetical protein Shew_1469 19 None None None 127512702 Common - excinuclease ATPase subunit Shew_1774 14 None None None 127514630 Common - glycosyl transferase, family 9 Shew_3702 110 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 127513944 Common - pyrroline-5-carboxylate reductase Shew_3016 210 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 127511841 Common - OmpA/MotB domain protein Shew_0908 169 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 127511836 Common - GCN5-related N-acetyltransferase Shew_0903 87 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 127512214 Common - hypothetical protein Shew_1282 42 COG3530 COG3530, Uncharacterized protein conserved in bacteria Function unknown 127513218 Common - protein of unknown function DUF606 Shew_2290 7 COG3238 COG3238, Uncharacterized protein conserved in bacteria Function unknown 127512091 Common - thioesterase superfamily protein Shew_1159 45 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 127512391 Common - Lysine exporter protein (LYSE/YGGA) Shew_1462 106 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 127512051 Common - hypothetical protein Shew_1118 18 COG4299 COG4299, Uncharacterized protein conserved in bacteria Function unknown 127513560 Common - ribosome recycling factor Shew_2632 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 127512757 Common - protein of unknown function DUF882 Shew_1829 63 COG3108 COG3108, Uncharacterized protein conserved in bacteria Function unknown 127514302 Common - protein of unknown function DUF1243 Shew_3374 30 COG3165 COG3165, Uncharacterized protein conserved in bacteria Function unknown 127513819 Common - hypothetical protein Shew_2891 5 None None None 127510959 Common - transcriptional regulator, ArsR family Shew_0024 145 COG0640 ArsR, Predicted transcriptional regulators Transcription 127512347 Common - undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase Shew_1417 222 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 127512912 Common - hypothetical protein Shew_1984 2 None None None 127514498 Common - two component transcriptional regulator, winged helix family Shew_3570 221 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127513602 Common - crotonobetainyl-CoA:carnitine CoA-transferase Shew_2674 111 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 127513930 Common - hypothetical protein Shew_3002 13 None None None 127511532 Common - ATP-dependent RNA helicase DbpA Shew_0598 232 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 127513863 Common - Peptidoglycan glycosyltransferase Shew_2935 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 127512072 Common - twitching motility protein Shew_1139 223 COG5008 PilU, Tfp pilus assembly protein, ATPase PilU Cell motility and secretion / Intracellular trafficking and secretion 127513965 Common - alpha-L-glutamate ligases, RimK family Shew_3037 117 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 127512425 Common - lipoprotein, putative Shew_1496 1 None None None 127514220 Common - hypothetical protein Shew_3292 5 COG3242 COG3242, Uncharacterized protein conserved in bacteria Function unknown 127513290 Common - dihydrodipicolinate synthase Shew_2362 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 127513327 Common folX D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase Shew_2399 44 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 127514576 Common - protein of unknown function DUF519 Shew_3648 85 COG2961 ComJ, Protein involved in catabolism of external DNA General function prediction only 127513690 Common - protein of unknown function DUF423 Shew_2762 66 COG2363 COG2363, Uncharacterized small membrane protein Function unknown 127513809 Common - Na(+)-translocating NADH-quinone reductase subunit A Shew_2881 40 COG1726 NqrA, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA Energy production and conversion 127513673 Common - hypothetical protein Shew_2745 13 None None None 127512940 Common - inner membrane transport protein YdhC Shew_2012 133 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 127511317 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) Shew_0383 195 COG0281 SfcA, Malic enzyme Energy production and conversion 127514061 Common - 3-methyl-2-oxobutanoate hydroxymethyltransferase Shew_3133 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 127512410 Common - short-chain dehydrogenase/reductase SDR Shew_1481 227 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 127511823 Common - secretion protein HlyD family protein Shew_0890 123 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 127512031 Common - riboflavin biosynthesis protein RibF Shew_1098 211 COG0196 RibF, FAD synthase Coenzyme metabolism 127514197 Common - Beta-galactosidase Shew_3269 72 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 127513303 Common - metal dependent phosphohydrolase Shew_2375 120 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 127513994 Common - 2-polyprenyl-6-methoxyphenol 4-hydroxylase Shew_3066 117 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 127514482 Common glnA glutamine synthetase Shew_3554 227 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 127513045 Common - ribonuclease activity regulator protein RraA Shew_2117 100 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 127513703 Common - MATE efflux family protein Shew_2775 137 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 127511932 Common rpsU 30S ribosomal protein S21 Shew_0999 99 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 127513278 Common - 2OG-Fe(II) oxygenase Shew_2350 11 None None None 127511503 Common - HflC protein Shew_0569 212 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 127513834 Common - hypothetical protein Shew_2906 30 COG2912 COG2912, Uncharacterized conserved protein Function unknown 127514059 Common - poly(A) polymerase Shew_3131 213 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 127514024 Common - metalloprotease MEP1-like protein Shew_3096 10 None None None 127511903 Common - transcriptional regulator, XRE family Shew_0970 95 COG1396 HipB, Predicted transcriptional regulators Transcription 127513251 Common - phosphate-starvation-inducible E Shew_2323 14 COG3223 COG3223, Predicted membrane protein Function unknown 127514532 Common - protein of unknown function DUF214 Shew_3604 110 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 127514609 Common - integral membrane sensor signal transduction histidine kinase Shew_3681 215 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 127513208 Common - phenylalanine/histidine ammonia-lyase Shew_2280 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 127514035 Common - peptidase M19, renal dipeptidase Shew_3107 101 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 127511981 Common - RNA polymerase sigma factor RpoE Shew_1048 174 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 127513699 Common - 1-deoxy-D-xylulose-5-phosphate synthase Shew_2771 214 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 127512606 Common - Leucyl aminopeptidase Shew_1677 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 127511512 Common argD bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein Shew_0578 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 127511874 Common - permease YjgP/YjgQ family protein Shew_0941 99 COG0795 COG0795, Predicted permeases General function prediction only 127511918 Common - phospholipase D/Transphosphatidylase Shew_0985 72 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 127512634 Nonpathogen - hypothetical protein Shew_1705 3 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 127513960 Common - hypothetical protein Shew_3032 4 None None None 127512461 Common - type III restriction enzyme, res subunit Shew_1532 151 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 127511039 Common - peptidase M14, carboxypeptidase A Shew_0105 16 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 127510974 Common - Oligopeptidase B Shew_0039 101 COG1770 PtrB, Protease II Amino acid transport and metabolism 127513089 Common - Peptidyl-dipeptidase Dcp Shew_2161 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 127514080 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Shew_3152 51 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 127513228 Nonpathogen - hypothetical protein Shew_2300 1 None None None 127511303 Common - cytochrome C oxidase subunit IV Shew_0369 53 COG3125 CyoD, Heme/copper-type cytochrome/quinol oxidase, subunit 4 Energy production and conversion 127512881 Common - cytidylate kinase Shew_1953 204 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 127514131 Common - hypothetical protein Shew_3203 50 COG5621 COG5621, Predicted secreted hydrolase General function prediction only 127513977 Common - major facilitator superfamily MFS_1 Shew_3049 35 None None None 127514688 Common - KAP P-loop domain protein Shew_3760 23 COG4928 COG4928, Predicted P-loop ATPase General function prediction only 127513235 Common - hypothetical protein Shew_2307 39 COG3170 FimV, Tfp pilus assembly protein FimV Cell motility and secretion / Intracellular trafficking and secretion 127513632 Common - Na(+)-translocating NADH-quinone reductase subunit F Shew_2704 172 COG2871 NqrF, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF Energy production and conversion 127511026 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Shew_0092 137 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 127513474 Common - hypothetical protein Shew_2546 15 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 127514280 Common - hypothetical protein Shew_3352 9 None None None 127513546 Common - diguanylate cyclase Shew_2618 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127513105 Nonpathogen - hypothetical protein Shew_2177 1 None None None 127514426 Common rpoZ DNA-directed RNA polymerase subunit omega Shew_3498 93 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 127511223 Common - acetolactate synthase 2 catalytic subunit Shew_0289 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 127511227 Common - threonine dehydratase Shew_0293 227 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 127514362 Common - N-acetyl-anhydromuranmyl-L-alanine amidase Shew_3434 109 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 127511691 Common - putative transcriptional regulator, CadC Shew_0757 1 COG3710 CadC, DNA-binding winged-HTH domains Transcription 127512603 Common - hypothetical protein Shew_1674 1 None None None 127514177 Common - integral membrane sensor signal transduction histidine kinase Shew_3249 215 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 127514078 Common - Antibiotic biosynthesis monooxygenase Shew_3150 8 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 127513418 Common - anion transporter Shew_2490 172 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 127514375 Common - hypothetical protein Shew_3447 14 COG4701 COG4701, Uncharacterized protein conserved in bacteria Function unknown 127513538 Common - AMP-dependent synthetase and ligase Shew_2610 201 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 127511391 Common - ATP-dependent helicase HepA Shew_0457 150 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 127511179 Common - molydopterin dinucleotide-binding region Shew_0245 86 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 127512279 Common flgE flagellar hook protein FlgE Shew_1348 127 COG1749 FlgE, Flagellar hook protein FlgE Cell motility and secretion 127513445 Common - ferrous iron transport protein B Shew_2517 170 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 127511369 Common - hypothetical protein Shew_0435 13 None None None 127511645 Common - Phosphoglycerate mutase Shew_0711 151 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 127513520 Common - peptidase M28 Shew_2592 45 COG2234 Iap, Predicted aminopeptidases General function prediction only 127513788 Common - acyl-CoA dehydrogenase domain protein Shew_2860 157 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 127514694 Common - heavy metal efflux pump, CzcA family Shew_3766 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 127511403 Common - pentapeptide repeat protein Shew_0469 74 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 127511159 Common - phosphoheptose isomerase Shew_0225 122 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 127512079 Common - hypothetical protein Shew_1146 1 None None None 127513122 Common - protein of unknown function DUF6, transmembrane Shew_2194 123 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 127513163 Common - DNA polymerase III, subunits gamma and tau Shew_2235 246 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 127513846 Nonpathogen - hypothetical protein Shew_2918 1 None None None 127514629 Nonpathogen - hypothetical protein Shew_3701 3 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 127514041 Common - histidine kinase Shew_3113 222 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 127513929 Common - extracellular solute-binding protein, family 3 Shew_3001 173 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 127512431 Common - protein of unknown function DUF748 Shew_1502 44 None None None 127513191 Common - methyl-accepting chemotaxis sensory transducer Shew_2263 148 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127513411 Common dinG ATP-dependent DNA helicase DinG Shew_2483 140 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 127512284 Common flgJ peptidoglycan hydrolase Shew_1353 69 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 127514348 Common - integral membrane sensor signal transduction histidine kinase Shew_3420 214 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127511172 Common - porin, Gram-negative type Shew_0238 15 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 127512681 Nonpathogen - hypothetical protein Shew_1753 1 None None None 127511098 Common rpsC 30S ribosomal protein S3 Shew_0164 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 127513565 Common - PII uridylyl-transferase Shew_2637 123 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 127511238 Common - protein of unknown function DUF526 Shew_0304 53 COG2960 COG2960, Uncharacterized protein conserved in bacteria Function unknown 127513079 Common - hypothetical protein Shew_2151 1 None None None 127514650 Common - protein of unknown function DUF885 Shew_3722 42 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 127511396 Nonpathogen - hypothetical protein Shew_0462 1 None None None 127514214 Nonpathogen - hypothetical protein Shew_3286 1 None None None 127514448 Common - hypothetical protein Shew_3520 33 COG4258 COG4258, Predicted exporter General function prediction only 127514549 Common - RNA-binding S4 domain protein Shew_3621 92 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 127512113 Common - PepSY-associated TM helix domain protein Shew_1181 32 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 127511615 Common - penicillin V acylase-like protein Shew_0681 23 COG3049 COG3049, Penicillin V acylase and related amidases Cell envelope biogenesis, outer membrane 127511030 Common - hypothetical protein Shew_0096 4 COG3212 COG3212, Predicted membrane protein Function unknown 127511997 Common rimM 16S rRNA-processing protein Shew_1064 185 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 127514125 Nonpathogen - hypothetical protein Shew_3197 2 None None None 127512573 Common - DSBA oxidoreductase Shew_1644 106 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 127514071 Common - aromatic acid decarboxylase Shew_3143 152 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 127514612 Common - binding-protein-dependent transport systems inner membrane component Shew_3684 184 COG4662 TupA, ABC-type tungstate transport system, periplasmic component Coenzyme metabolism 127512744 Common - ribosome modulation factor Shew_1816 21 COG3130 Rmf, Ribosome modulation factor Translation, ribosomal structure and biogenesis 127512123 Common nusB transcription antitermination protein NusB Shew_1191 197 COG0781 NusB, Transcription termination factor Transcription 127513739 Common - membrane protein Shew_2811 1 COG3726 AhpA, Uncharacterized membrane protein affecting hemolysin expression General function prediction only 127514334 Common - secretion protein HlyD family protein Shew_3406 154 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 127513826 Common - hypothetical protein Shew_2898 23 COG3085 COG3085, Uncharacterized protein conserved in bacteria Function unknown 127513376 Common nrdG anaerobic ribonucleotide reductase-activating protein Shew_2448 65 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 127511634 Common - Pirin domain protein domain protein Shew_0700 148 COG1741 COG1741, Pirin-related protein General function prediction only 127511796 Common - binding-protein-dependent transport systems inner membrane component Shew_0862 185 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 127512326 Common - VacJ family lipoprotein Shew_1395 94 COG2853 VacJ, Surface lipoprotein Cell envelope biogenesis, outer membrane 127512879 Common - aromatic amino acid aminotransferase Shew_1951 73 COG1448 TyrB, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 127512655 Common - transcriptional regulator, LuxR family Shew_1726 138 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 127511720 Common - hypothetical protein Shew_0786 2 None None None 127511481 Common - Calcineurin phosphoesterase C-terminal domain protein Shew_0547 78 COG1409 Icc, Predicted phosphohydrolases General function prediction only 127512298 Common fliG flagellar motor switch protein G Shew_1367 125 COG1536 FliG, Flagellar motor switch protein Cell motility and secretion 127511663 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Shew_0729 239 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 127514011 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Shew_3083 76 COG0348 NapH, Polyferredoxin Energy production and conversion 127511433 Nonpathogen - Xaa-Pro aminopeptidase family enzyme Shew_0499 8 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 127511456 Common metF 5,10-methylenetetrahydrofolate reductase Shew_0522 142 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 127512181 Common - phosphoribosylaminoimidazole carboxylase, ATPase subunit Shew_1249 192 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 127513066 Common - hypothetical protein Shew_2138 4 None None None 127514614 Common - molybdopterin-guanine dinucleotide biosynthesis protein A Shew_3686 93 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 127513140 Common - Peptidyl-dipeptidase Dcp Shew_2212 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 127511034 Nonpathogen - protein of unknown function UPF0057 Shew_0100 1 COG0401 COG0401, Uncharacterized homolog of Blt101 Function unknown 127514192 Common - FxsA cytoplasmic membrane protein Shew_3264 67 COG3030 FxsA, Protein affecting phage T7 exclusion by the F plasmid General function prediction only 127513763 Common rrmJ 23S rRNA methyltransferase J Shew_2835 138 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 127511152 Common - hypothetical protein Shew_0218 2 None None None 127511807 Common - hypothetical protein Shew_0873 43 COG3610 COG3610, Uncharacterized conserved protein Function unknown 127514659 Common - DNA topoisomerase, type IA, zn finger domain protein Shew_3731 134 COG0551 TopA, Zn-finger domain associated with topoisomerase type I DNA replication, recombination, and repair 127514754 Common - transposon Tn7 transposition protein TnsC Shew_3826 19 None None None 127512010 Common - hypothetical protein Shew_1077 1 None None None 127512888 Common - hypothetical protein Shew_1960 29 COG3122 COG3122, Uncharacterized protein conserved in bacteria Function unknown 127514764 Common - glucosamine--fructose-6-phosphate aminotransferase, isomerizing Shew_3839 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 127513980 Common - transcriptional regulator, AraC family Shew_3052 75 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 127512066 Common - hypothetical protein Shew_1133 13 None None None 127512713 Common - band 7 protein Shew_1785 214 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 127514164 Nonpathogen - hypothetical protein Shew_3236 1 None None None 127512125 Common - Phosphatidylglycerophosphatase Shew_1193 104 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 127511380 Common - hypothetical protein Shew_0446 1 None None None 127514724 Common - transporter, hydrophobe/amphiphile efflux-1 (HAE1) family Shew_3796 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 127513152 Common - DNA topoisomerase I Shew_2224 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 127512146 Common - DNA mismatch repair protein Shew_1214 205 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 127513758 Common secG preprotein translocase subunit SecG Shew_2830 23 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 127512496 Common - translation initiation factor IF-1 Shew_1567 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 127511333 Common - methylation site containing protein Shew_0399 10 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 127511850 Common - transcriptional regulator, LysR family Shew_0917 40 COG0583 LysR, Transcriptional regulator Transcription 127511437 Common - thioredoxin domain protein Shew_0503 17 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 127513025 Common - hypothetical protein Shew_2097 1 None None None 127512160 Common - hypothetical protein Shew_1228 1 None None None 127512618 Common - hypothetical protein Shew_1689 22 None None None 127513181 Common - anthranilate phosphoribosyltransferase Shew_2253 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 127511769 Common - peptidase M1, membrane alanine aminopeptidase Shew_0835 68 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 127512289 Common - flagellar protein FlaG protein Shew_1358 27 COG1334 FlaG, Uncharacterized flagellar protein FlaG Cell motility and secretion 127514378 Common - cell division protein FtsA Shew_3450 189 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 127514734 Common - phosphoglyceromutase Shew_3806 125 COG0696 GpmI, Phosphoglyceromutase Carbohydrate transport and metabolism 127511197 Common - hypothetical protein Shew_0263 4 None None None 127513920 Common - amidohydrolase Shew_2992 95 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 127514253 Common - major facilitator superfamily MFS_1 Shew_3325 70 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 127513161 Common - recombination protein RecR Shew_2233 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 127513593 Common - beta-ketoacyl synthase Shew_2665 210 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 127512977 Common - DNA-binding transcriptional regulator HexR Shew_2049 96 COG1737 RpiR, Transcriptional regulators Transcription 127511792 Common - oxidoreductase FAD/NAD(P)-binding domain protein Shew_0858 115 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 127511976 Common - hypothetical protein Shew_1043 2 None None None 127512564 Common - diguanylate cyclase Shew_1635 178 COG3452 COG3452, Predicted periplasmic ligand-binding sensor domain Signal transduction mechanisms 127514442 Common - hypothetical protein Shew_3514 81 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 127512026 Common - protein of unknown function DUF328 Shew_1093 91 COG3022 COG3022, Uncharacterized protein conserved in bacteria Function unknown 127513027 Common - DTW domain containing protein Shew_2099 35 COG3148 COG3148, Uncharacterized conserved protein Function unknown 127511561 Common - hypothetical protein Shew_0627 4 None None None 127513883 Common - ornithine cyclodeaminase Shew_2955 97 COG2423 COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog Amino acid transport and metabolism 127514310 Common - delta-aminolevulinic acid dehydratase Shew_3382 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 127511112 Common secY preprotein translocase subunit SecY Shew_0178 232 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 127512476 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Shew_1547 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 127511748 Common - pseudouridine synthase Shew_0814 202 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 127512094 Common - hypothetical protein Shew_1162 1 None None None 127512719 Common - two component transcriptional regulator, winged helix family Shew_1791 205 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127512726 Common - Paraquat-inducible protein A Shew_1798 50 COG2995 PqiA, Uncharacterized paraquat-inducible protein A Function unknown 127514018 Common - hypothetical protein Shew_3090 9 COG4519 COG4519, Uncharacterized protein conserved in bacteria Function unknown 127511136 Common argC N-acetyl-gamma-glutamyl-phosphate reductase Shew_0202 214 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 127511123 Common - heme exporter protein CcmB Shew_0189 94 COG2386 CcmB, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 127511255 Common - hypothetical protein Shew_0321 1 None None None 127511671 Common - transcriptional regulator, MarR family with acetyltransferase activity Shew_0737 70 COG1846 MarR, Transcriptional regulators Transcription 127512351 Common - sulfate adenylyltransferase subunit 2 Shew_1422 136 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 127511626 Common - hypothetical protein Shew_0692 2 None None None 127511405 Common groES co-chaperonin GroES Shew_0471 214 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 127513141 Common - lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase Shew_2213 91 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 127511712 Common - hypothetical protein Shew_0778 5 None None None 127513104 Common - Disulphide bond formation protein DsbB Shew_2176 57 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 127511740 Common - MltA-interacting MipA family protein Shew_0806 5 COG3713 OmpV, Outer membrane protein V Cell envelope biogenesis, outer membrane 127512303 Common fliL flagellar basal body-associated protein FliL Shew_1372 17 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 127514637 Common - 2-amino-3-ketobutyrate coenzyme A ligase Shew_3709 193 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 127514172 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Shew_3244 164 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 127514726 Common - transcriptional regulator, LysR family Shew_3798 184 COG0583 LysR, Transcriptional regulator Transcription 127514179 Common - UBA/THIF-type NAD/FAD binding protein Shew_3251 211 COG1179 COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Coenzyme metabolism 127512609 Common - HPP family protein+B94 Shew_1680 75 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 127513455 Common - outer membrane protein precursor MtrB Shew_2527 9 None None None 127513330 Common - ABC transporter-related protein Shew_2402 249 COG4181 COG4181, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 127513115 Common - ribonuclease D Shew_2187 120 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 127514463 Common - efflux transporter, RND family, MFP subunit Shew_3535 159 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 127512227 Common - hypothetical protein Shew_1295 4 None None None 127511447 Common - ABC transporter-related protein Shew_0513 242 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 127512406 Common - anti-ECFsigma factor, ChrR Shew_1477 29 COG3806 ChrR, Transcriptional activator Transcription 127512663 Common - protein of unknown function DUF1425 Shew_1734 9 COG5633 COG5633, Predicted periplasmic lipoprotein General function prediction only 127513272 Common - hypothetical protein Shew_2344 1 None None None 127512104 Common - Starch synthase Shew_1172 126 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 127514142 Common - hypothetical protein Shew_3214 7 None None None 127513264 Common - preprotein translocase, YajC subunit Shew_2336 174 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 127512250 Common - DegT/DnrJ/EryC1/StrS aminotransferase Shew_1319 192 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 127512367 Common - fumarylacetoacetate (FAA) hydrolase Shew_1438 47 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 127514706 Common - ABC transporter-related protein Shew_3778 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 127514247 Nonpathogen - hypothetical protein Shew_3319 1 None None None 127511206 Common - Cupin 2, conserved barrel domain protein Shew_0272 1 None None None 127513720 Common - phospholipid/glycerol acyltransferase Shew_2792 56 COG3176 COG3176, Putative hemolysin General function prediction only 127511217 Common - Mg chelatase, subunit ChlI Shew_0283 199 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 127513359 Common - Tetratricopeptide TPR_2 repeat protein Shew_2431 56 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 127510944 Common glyS glycyl-tRNA synthetase subunit beta Shew_0009 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 127513641 Common - metal dependent phosphohydrolase Shew_2713 120 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 127514745 Common - plastocyanin domain-containing putative secreted protein Shew_3817 16 COG4633 COG4633, Uncharacterized protein conserved in bacteria Function unknown 127511180 Common - hypothetical protein Shew_0246 9 None None None 127514056 Common - sugar fermentation stimulation protein Shew_3128 108 COG1489 SfsA, DNA-binding protein, stimulates sugar fermentation General function prediction only 127514712 Nonpathogen - hypothetical protein Shew_3784 1 None None None 127514771 Common - F0F1 ATP synthase subunit gamma Shew_3846 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 127512251 Common - Methyltransferase type 12 Shew_1320 17 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 127512958 Common rpmI 50S ribosomal protein L35 Shew_2030 133 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 127513927 Nonpathogen - hypothetical protein Shew_2999 2 None None None 127511062 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Shew_0128 36 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 127513004 Common - Holliday junction DNA helicase RuvA Shew_2076 211 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 127511591 Common - putative nitric oxide reductase (subunit B) transmembrane protein Shew_0657 72 COG3256 NorB, Nitric oxide reductase large subunit Inorganic ion transport and metabolism 127512595 Common - putative esterase Shew_1666 49 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 127514392 Nonpathogen - ferredoxin Shew_3464 6 COG2871 NqrF, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF Energy production and conversion 127513339 Common - FAD dependent oxidoreductase Shew_2411 55 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 127513575 Common - hypothetical protein Shew_2647 21 COG4323 COG4323, Predicted membrane protein Function unknown 127511685 Common - S-adenosylmethionine synthetase Shew_0751 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 127514266 Common - TOBE domain protein Shew_3338 72 COG3585 MopI, Molybdopterin-binding protein Coenzyme metabolism 127511440 Common - transcriptional regulator, LysR family Shew_0506 157 COG0583 LysR, Transcriptional regulator Transcription 127513350 Common - hypothetical protein Shew_2422 4 None None None 127513155 Common - sodium:dicarboxylate symporter Shew_2227 165 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 127513246 Common - transcriptional regulator, BadM/Rrf2 family Shew_2318 173 COG1959 COG1959, Predicted transcriptional regulator Transcription 127513293 Common - transcriptional regulator, GntR family Shew_2365 134 COG1802 GntR, Transcriptional regulators Transcription 127513386 Common - Glutathione S-transferase, C-terminal domain Shew_2458 97 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 127511553 Common - adenylate cyclase Shew_0619 56 COG3025 COG3025, Uncharacterized conserved protein Function unknown 127513241 Common hscA chaperone protein HscA Shew_2313 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 127514405 Common - hypothetical protein Shew_3477 1 None None None 127513372 Common - hypothetical protein Shew_2444 37 COG4628 COG4628, Uncharacterized conserved protein Function unknown 127511800 Common - arginine repressor Shew_0866 77 COG1438 ArgR, Arginine repressor Transcription 127511855 Common - methyl-accepting chemotaxis sensory transducer Shew_0922 145 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127512481 Common - transcriptional regulator, MarR family Shew_1552 111 COG1846 MarR, Transcriptional regulators Transcription 127512578 Common - efflux transporter, RND family, MFP subunit Shew_1649 179 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 127512416 Common - hypothetical protein Shew_1487 36 None None None 127512908 Common - hypothetical protein Shew_1980 27 COG0716 FldA, Flavodoxins Energy production and conversion 127511739 Nonpathogen - hypothetical protein Shew_0805 1 None None None 127511050 Common - electron transport protein SCO1/SenC Shew_0116 105 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 127512020 Common - hypothetical protein Shew_1087 1 None None None 127513586 Common - ABC transporter-related protein Shew_2658 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 127512083 Common - transmembrane pair domain protein Shew_1150 41 COG4125 COG4125, Predicted membrane protein Function unknown 127511266 Common - fumarate reductase respiratory complex, transmembrane subunit Shew_0332 10 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 127512231 Common - CMP/dCMP deaminase, zinc-binding Shew_1299 216 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 127512073 Common - Ferrochelatase Shew_1140 163 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 127513531 Common - hypothetical protein Shew_2603 20 COG4551 COG4551, Predicted protein tyrosine phosphatase General function prediction only 127513737 Common - alpha/beta hydrolase fold Shew_2809 12 COG4757 COG4757, Predicted alpha/beta hydrolase General function prediction only 127512377 Common - hypothetical protein Shew_1448 2 None None None 127512338 Common - short-chain dehydrogenase/reductase SDR Shew_1407 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 127511187 Common - secretion protein HlyD family protein Shew_0253 144 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 127513922 Common - transcriptional repressor, CopY family Shew_2994 45 COG3682 COG3682, Predicted transcriptional regulator Transcription 127513844 Common - ribose-phosphate pyrophosphokinase Shew_2916 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 127513138 Common - Proprotein convertase, P Shew_2210 11 COG4935 COG4935, Regulatory P domain of the subtilisin-like proprotein convertases and other proteases Posttranslational modification, protein turnover, chaperones 127511490 Common - protein of unknown function DUF6, transmembrane Shew_0556 69 COG2962 RarD, Predicted permeases General function prediction only 127513017 Common - SrpA-related protein Shew_2089 19 None None None 127511242 Common - hypothetical protein Shew_0308 34 COG3672 COG3672, Predicted periplasmic protein Function unknown 127511938 Common - rRNA (guanine-N(1)-)-methyltransferase Shew_1005 55 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 127514642 Common - DNA polymerase I Shew_3714 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 127514120 Common - uncharacterized domain 1 protein Shew_3192 93 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 127513893 Common - putative manganese transporter Shew_2965 24 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 127513481 Common - short-chain dehydrogenase/reductase SDR Shew_2553 85 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 127512034 Common - peptidylprolyl isomerase, FKBP-type Shew_1101 121 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 127512587 Common - succinyl-CoA synthetase, alpha subunit Shew_1658 216 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 127511002 Nonpathogen - hypothetical protein Shew_0067 1 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 127512732 Common - hypothetical protein Shew_1804 6 None None None 127514485 Common - hypothetical protein Shew_3557 4 None None None 127512526 Common - maf protein Shew_1597 187 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 127514150 Common - protein of unknown function DUF335, SprT Shew_3222 26 COG3091 SprT, Uncharacterized protein conserved in bacteria Function unknown 127514204 Common - hypothetical protein Shew_3276 4 COG0729 COG0729, Outer membrane protein Cell envelope biogenesis, outer membrane 127512374 Common - Tripartite ATP-independent periplasmic transporter, DctQ component Shew_1445 62 COG3090 DctM, TRAP-type C4-dicarboxylate transport system, small permease component Carbohydrate transport and metabolism 127511629 Common - protein of unknown function DUF331 Shew_0695 17 COG3036 COG3036, Uncharacterized protein conserved in bacteria Function unknown 127514159 Common - protein of unknown function DUF342 Shew_3231 37 COG1315 COG1315, Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain DNA replication, recombination, and repair 127511999 Common rplS 50S ribosomal protein L19 Shew_1066 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 127513595 Common - Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ Shew_2667 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 127514691 Common - transcriptional regulator, LuxR family Shew_3763 9 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 127512927 Common - aromatic amino acid aminotransferase Shew_1999 71 COG1448 TyrB, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 127513815 Common - sterol desaturase family protein Shew_2887 73 COG3000 ERG3, Sterol desaturase Lipid metabolism 127511644 Common metH B12-dependent methionine synthase Shew_0710 179 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 127513752 Common rpsO 30S ribosomal protein S15 Shew_2824 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 127511161 Common - LppC family lipoprotein Shew_0227 43 COG3107 LppC, Putative lipoprotein General function prediction only 127511292 Common - transcriptional regulator, CadC Shew_0358 4 COG3710 CadC, DNA-binding winged-HTH domains Transcription 127511526 Common - hypothetical protein Shew_0592 3 COG5589 COG5589, Uncharacterized conserved protein Function unknown 127512886 Common - orotidine 5'-phosphate decarboxylase Shew_1958 160 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 127512847 Common - hypothetical protein Shew_1919 8 None None None 127511372 Common - GumN family protein Shew_0438 41 COG3735 COG3735, Uncharacterized protein conserved in bacteria Function unknown 127511299 Nonpathogen - hypothetical protein Shew_0365 1 None None None 127514103 Common - outer membrane porin Shew_3175 9 None None None 127513648 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Shew_2720 106 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 127514365 Common - O-antigen polymerase Shew_3437 8 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 127514203 Common - CheC domain protein Shew_3275 29 COG1406 COG1406, Predicted inhibitor of MCP methylation, homolog of CheC Cell motility and secretion 127512276 Common flgB flagellar basal body rod protein FlgB Shew_1345 91 COG1815 FlgB, Flagellar basal body protein Cell motility and secretion 127511340 Common - maf protein Shew_0406 197 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 127511818 Common - Nucleotidyl transferase Shew_0884 226 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 127511928 Common - phage integrase family protein Shew_0995 48 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 127514620 Common coaD phosphopantetheine adenylyltransferase Shew_3692 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 127511057 Common - cytochrome C oxidase assembly protein Shew_0123 68 COG3175 COX11, Cytochrome oxidase assembly factor Posttranslational modification, protein turnover, chaperones 127512817 Common - alpha amylase, catalytic region Shew_1889 165 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 127512548 Common - arginine decarboxylase Shew_1619 87 COG1166 SpeA, Arginine decarboxylase (spermidine biosynthesis) Amino acid transport and metabolism 127512582 Common sdhA succinate dehydrogenase flavoprotein subunit Shew_1653 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 127510978 Nonpathogen - hypothetical protein Shew_0043 2 None None None 127514332 Common - NosL family protein Shew_3404 25 COG4314 NosL, Predicted lipoprotein involved in nitrous oxide reduction Energy production and conversion 127511101 Common - ribosomal protein S17 Shew_0167 238 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 127513716 Common - peptidase U32 Shew_2788 49 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 127514186 Common - two component heavy metal response transcriptional regulator, winged helix family Shew_3258 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127512852 Common - succinylglutamate desuccinylase Shew_1924 24 COG2988 COG2988, Succinylglutamate desuccinylase Amino acid transport and metabolism 127512931 Nonpathogen - hypothetical protein Shew_2003 1 None None None 127511514 Common - aldehyde dehydrogenase Shew_0580 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 127511942 Common - Peptidoglycan-binding domain 1 protein Shew_1009 73 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 127511700 Common - efflux transporter, RND family, MFP subunit Shew_0766 133 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 127514399 Common - 3-isopropylmalate dehydrogenase Shew_3471 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 127512046 Common - tryptophan halogenase Shew_1113 16 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 127513408 Common - TonB-dependent receptor Shew_2480 104 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 127512862 Common - hypothetical protein Shew_1934 8 None None None 127511347 Common - ABC-2 type transporter Shew_0413 60 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 127513709 Common - diguanylate cyclase/phosphodiesterase Shew_2781 163 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 127513678 Common - porin, Gram-negative type Shew_2750 46 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 127513471 Common - glyoxalase family protein Shew_2543 25 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 127512946 Common - DsrC family protein Shew_2018 60 COG2920 DsrC, Dissimilatory sulfite reductase (desulfoviridin), gamma subunit Inorganic ion transport and metabolism 127512536 Common - thioesterase superfamily protein Shew_1607 134 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 127510988 Common - formate dehydrogenase, subunit FdhD Shew_0053 136 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 127513906 Common - extracellular solute-binding protein, family 3 Shew_2978 36 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 127512672 Common - GCN5-related N-acetyltransferase Shew_1743 64 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 127513747 Common - hypothetical protein Shew_2819 1 None None None 127511177 Common - transcriptional regulator, LysR family Shew_0243 67 COG0583 LysR, Transcriptional regulator Transcription 127511427 Common - hypothetical protein Shew_0493 5 None None None 127513876 Common - ATPase AAA-2 domain protein Shew_2948 215 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 127512632 Nonpathogen - hypothetical protein Shew_1703 1 None None None 127511916 Common - amidohydrolase Shew_0983 73 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 127512504 Common - uridine kinase Shew_1575 95 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 127511956 Common - hypothetical protein Shew_1023 1 None None None 127512835 Common - glutathione-dependent formaldehyde-activating, GFA Shew_1907 57 COG3791 COG3791, Uncharacterized conserved protein Function unknown 127514664 Common - peptide deformylase Shew_3736 214 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 127511986 Common - signal peptidase I Shew_1053 210 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 127514673 Common - glycoside hydrolase, family 37 Shew_3745 51 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 127513034 Common - hypothetical protein Shew_2106 18 None None None 127513499 Common - Propionyl-CoA carboxylase Shew_2571 147 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 127512447 Common - hypothetical protein Shew_1518 9 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 127511004 Common - hypothetical protein Shew_0069 11 COG3904 COG3904, Predicted periplasmic protein Function unknown 127514719 Nonpathogen - hypothetical protein Shew_3791 1 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 127514353 Common - predicted hydrolase Shew_3425 202 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 127514321 Common - hypothetical protein Shew_3393 3 None None None 127513871 Common - ribosomal-protein-alanine acetyltransferase Shew_2943 195 COG0456 RimI, Acetyltransferases General function prediction only 127513729 Common - multi-sensor hybrid histidine kinase Shew_2801 211 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127512200 Common smpB SsrA-binding protein Shew_1268 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 127511073 Common - glutamate racemase Shew_0139 191 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 127511863 Common - AMMECR1 domain protein Shew_0930 73 COG2078 AMMECR1, Uncharacterized conserved protein Function unknown 127514305 Common - twin-arginine translocation protein, TatB subunit Shew_3377 27 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 127514358 Common - pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase Shew_3430 197 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 127514138 Nonpathogen - hypothetical protein Shew_3210 1 None None None 127514433 Common - integral membrane sensor signal transduction histidine kinase Shew_3505 116 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 127513543 Common - Patatin Shew_2615 47 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 127510992 Common - cytoplasmic chaperone TorD family protein Shew_0057 31 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 127512264 Common - 3-oxoacyl-(acyl-carrier-protein) synthase Shew_1333 201 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 127512688 Common - (NiFe) hydrogenase maturation protein HypF Shew_1760 135 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 127514589 Nonpathogen - hypothetical protein Shew_3661 1 None None None 127511286 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Shew_0352 164 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 127514783 Common - ubiquinone biosynthesis O-methyltransferase Shew_3858 153 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 127511326 Common - type II secretion system protein E Shew_0392 222 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 127511201 Common - protein of unknown function DUF904 Shew_0267 1 None None None 127513952 Common - Amidohydrolase 3 Shew_3024 113 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 127514516 Common - drug resistance transporter, Bcr/CflA subfamily Shew_3588 147 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 127514788 Common - AAA ATPase, central domain protein Shew_3863 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 127512152 Common - pyruvate carboxylase subunit B Shew_1220 193 COG5016 COG5016, Pyruvate/oxaloacetate carboxyltransferase Energy production and conversion 127511170 Common - transcriptional regulator, LysR family Shew_0236 169 COG0583 LysR, Transcriptional regulator Transcription 127512292 Common fliS flagellar protein FliS Shew_1361 84 COG1516 FliS, Flagellin-specific chaperone FliS Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 127513740 Common deoD purine nucleoside phosphorylase Shew_2812 98 COG0813 DeoD, Purine-nucleoside phosphorylase Nucleotide transport and metabolism 127511772 Common - SlyX family protein Shew_0838 36 COG2900 SlyX, Uncharacterized protein conserved in bacteria Function unknown 127512342 Common - transferase hexapeptide repeat containing protein Shew_1411 187 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 127514087 Common - uncharacterized FlgJ-related protein-like Shew_3159 31 COG2992 Bax, Uncharacterized FlgJ-related protein General function prediction only 127511409 Common - hypothetical protein Shew_0475 5 None None None 127512876 Common - 3-demethylubiquinone-9 3-methyltransferase Shew_1948 159 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 127514005 Common - peptidase S10, serine carboxypeptidase Shew_3077 37 COG2939 COG2939, Carboxypeptidase C (cathepsin A) Amino acid transport and metabolism 127513774 Nonpathogen - hypothetical protein Shew_2846 2 None None None 127512230 Common guaA bifunctional GMP synthase/glutamine amidotransferase protein Shew_1298 239 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 127513609 Common - General substrate transporter Shew_2681 188 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 127513524 Common - prolyl-tRNA synthetase Shew_2596 247 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 127514471 Common - hypothetical protein Shew_3543 2 None None None 127514478 Common - transcriptional regulator, AraC family Shew_3550 67 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 127512197 Nonpathogen - hypothetical protein Shew_1265 1 None None None 127514582 Common - AbgT putative transporter Shew_3654 40 COG2978 AbgT, Putative p-aminobenzoyl-glutamate transporter Coenzyme metabolism 127511241 Common - diguanylate cyclase/phosphodiesterase Shew_0307 153 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 127512777 Common - NlpBDapX family lipoprotein Shew_1849 40 COG3317 NlpB, Uncharacterized lipoprotein Cell envelope biogenesis, outer membrane 127512696 Common - periplasmic nitrate reductase NapE Shew_1768 1 COG4459 NapE, Periplasmic nitrate reductase system, NapE component Energy production and conversion 127511811 Common apaH diadenosine tetraphosphatase Shew_0877 79 COG0639 ApaH, Diadenosine tetraphosphatase and related serine/threonine protein phosphatases Signal transduction mechanisms 127512759 Common - hypothetical protein Shew_1831 71 COG2719 SpoVR, Uncharacterized conserved protein Function unknown 127511577 Common - type II secretion system protein Shew_0643 88 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 127514343 Common - short chain dehydrogenase Shew_3415 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 127512796 Common - methyl-accepting chemotaxis sensory transducer Shew_1868 152 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127512209 Common - putative signal transduction protein Shew_1277 43 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 127513796 Common - acyl-CoA dehydrogenase domain protein Shew_2868 151 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 127514676 Common - protein of unknown function DUF833 Shew_3748 48 COG3332 COG3332, Uncharacterized conserved protein Function unknown 127511248 Common - putative outer membrane adhesin like proteiin Shew_0314 145 COG2931 COG2931, RTX toxins and related Ca2+-binding proteins Secondary metabolites biosynthesis, transport, and catabolism 127512679 Nonpathogen - hypothetical protein Shew_1751 2 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 127511619 Common - hypothetical protein Shew_0685 10 None None None 127512556 Common - hypothetical protein Shew_1627 19 COG3150 COG3150, Predicted esterase General function prediction only 127511418 Nonpathogen - hypothetical protein Shew_0484 1 None None None 127511814 Common - 4-hydroxythreonine-4-phosphate dehydrogenase Shew_0880 159 COG1995 PdxA, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 127512589 Common - GCN5-related N-acetyltransferase Shew_1660 89 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 127511693 Common - cytochrome c, putative Shew_0759 7 None None None 127513292 Common - aldehyde dehydrogenase Shew_2364 207 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 127513244 Common - scaffold protein Shew_2316 157 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 127513212 Common - hypothetical protein Shew_2284 5 None None None 127513865 Common - lytic murein transglycosylase B Shew_2937 102 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 127512272 Common - anti-sigma-28 factor, FlgM Shew_1341 8 COG2747 FlgM, Negative regulator of flagellin synthesis (anti-sigma28 factor) Transcription / Cell motility and secretion / Intracellular trafficking and secretion 127513324 Common - hypothetical protein Shew_2396 1 None None None 127512111 Common - type IV pilin biogenesis protein, putative Shew_1179 37 COG3419 PilY1, Tfp pilus assembly protein, tip-associated adhesin PilY1 Cell motility and secretion / Intracellular trafficking and secretion 127512433 Common - GCN5-related N-acetyltransferase Shew_1504 24 COG0456 RimI, Acetyltransferases General function prediction only 127513160 Common - heat shock protein 90 Shew_2232 150 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 127511934 Common - hypothetical protein Shew_1001 169 COG0344 COG0344, Predicted membrane protein Function unknown 127512942 Common - protein of unknown function UPF0005 Shew_2014 107 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 127511219 Common - diguanylate cyclase Shew_0285 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127513967 Common - protein of unknown function DUF159 Shew_3039 98 COG2135 COG2135, Uncharacterized conserved protein Function unknown 127513300 Common - hypothetical protein Shew_2372 53 COG4327 COG4327, Predicted membrane protein Function unknown 127512459 Common - porin Shew_1530 25 None None None 127511865 Common - Radical SAM domain protein Shew_0932 89 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 127513621 Common - hypothetical protein Shew_2693 4 None None None 127514248 Nonpathogen - putative FG-GAP repeat lipoprotein Shew_3320 2 None None None 127513305 Common - DNA ligase, NAD-dependent Shew_2377 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 127512903 Common - putative manganese-dependent inorganic pyrophosphatase Shew_1975 54 COG1227 PPX1, Inorganic pyrophosphatase/exopolyphosphatase Energy production and conversion 127513332 Common - hypothetical protein Shew_2404 18 None None None 127513705 Common - DEAD/DEAH box helicase domain protein Shew_2777 240 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 127512372 Common - integral membrane sensor signal transduction histidine kinase Shew_1443 223 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 127511505 Common - Cytochrome b/b6, N-terminal domain Shew_0571 149 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 127513006 Common - protein of unknown function DUF28 Shew_2078 213 COG0217 COG0217, Uncharacterized conserved protein Function unknown 127514607 Common - hypothetical protein Shew_3679 102 COG1738 COG1738, Uncharacterized conserved protein Function unknown 127512621 Nonpathogen - hypothetical protein Shew_1692 1 None None None 127513756 Common nusA transcription elongation factor NusA Shew_2828 218 COG0195 NusA, Transcription elongation factor Transcription 127513135 Common - integral membrane sensor signal transduction histidine kinase Shew_2207 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127511510 Common - peptidase S9, prolyl oligopeptidase active site domain protein Shew_0576 112 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 127512864 Common - two component transcriptional regulator, winged helix family Shew_1936 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127513950 Common - hypothetical protein Shew_3022 20 COG3235 COG3235, Predicted membrane protein Function unknown 127513226 Common - putative alpha-glucosidase Shew_2298 18 None None None 127511791 Common - hypothetical protein Shew_0857 9 None None None 127513171 Common - transcriptional regulator, TraR/DksA family Shew_2243 13 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 127512543 Common - cold-shock DNA-binding domain protein Shew_1614 182 COG1278 CspC, Cold shock proteins Transcription 127512978 Common - Pyruvate kinase Shew_2050 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 127513040 Common - ribonuclease H Shew_2112 177 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 127514336 Common - hypothetical protein Shew_3408 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 127512965 Common - MATE efflux family protein Shew_2037 145 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 127510972 Common - phosphoesterase, PA-phosphatase related Shew_0037 15 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 127511910 Common - FAD dependent oxidoreductase Shew_0977 118 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 127512775 Common - amino acid-binding ACT domain protein Shew_1847 40 COG2716 GcvR, Glycine cleavage system regulatory protein Amino acid transport and metabolism 127514022 Common - protein of unknown function DUF81 Shew_3094 68 COG0730 COG0730, Predicted permeases General function prediction only 127513713 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Shew_2785 111 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 127511876 Common - hypothetical protein Shew_0943 6 None None None 127514297 Common - hypothetical protein Shew_3369 12 None None None 127511301 Common - Cytochrome-c oxidase Shew_0367 166 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 127513087 Common - methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor Shew_2159 152 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127513600 Common - carnitinyl-CoA dehydratase Shew_2672 178 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 127512005 Common - chorismate mutase Shew_1072 222 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 127512925 Common - bax protein, putative Shew_1997 31 COG2992 Bax, Uncharacterized FlgJ-related protein General function prediction only 127511575 Common - protein of unknown function DUF192 Shew_0641 17 COG1430 COG1430, Uncharacterized conserved protein Function unknown 127514048 Common - phosphate-selective porin O and P Shew_3120 23 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 127514062 Common - pantoate--beta-alanine ligase Shew_3134 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 127511205 Common - phospholipase Shew_0271 9 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 127512212 Common - transcriptional regulator, CopG family Shew_1280 3 None None None 127514773 Common - ATP synthase F1, delta subunit Shew_3848 163 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 127511133 Common - protein of unknown function DUF1439 Shew_0199 19 None None None 127511890 Common - protein of unknown function DUF1294 Shew_0957 54 COG3326 COG3326, Predicted membrane protein Function unknown 127512601 Common - 3-hydroxyisobutyrate dehydrogenase Shew_1672 165 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 127513626 Common - hypothetical protein Shew_2698 16 None None None 127513859 Common - DNA polymerase III, delta subunit Shew_2931 66 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 127512384 Common - dual specificity protein phosphatase Shew_1455 8 COG2453 CDC14, Predicted protein-tyrosine phosphatase Signal transduction mechanisms 127514145 Common - sodium/hydrogen exchanger Shew_3217 204 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 127511116 Common rpsD 30S ribosomal protein S4 Shew_0182 216 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 127511028 Common - ABC transporter-related protein Shew_0094 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 127514169 Common - TonB-dependent receptor Shew_3241 87 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 127512498 Common aat leucyl/phenylalanyl-tRNA--protein transferase Shew_1569 134 COG2360 Aat, Leu/Phe-tRNA-protein transferase Posttranslational modification, protein turnover, chaperones 127514068 Common - ABC-2 type transporter Shew_3140 180 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 127512017 Common - PAS/PAC sensor hybrid histidine kinase Shew_1084 198 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127513937 Common - transposase IS116/IS110/IS902 family protein Shew_3009 88 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 127513783 Nonpathogen - hypothetical protein Shew_2855 1 None None None 127514652 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Shew_3724 188 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 127513654 Common - protein of unknown function DUF188 Shew_2726 97 COG1671 COG1671, Uncharacterized protein conserved in bacteria Function unknown 127514416 Common - ribonuclease PH Shew_3488 185 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 127512088 Common - hypothetical protein Shew_1156 6 None None None 127514235 Common - 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase Shew_3307 102 COG1778 COG1778, Low specificity phosphatase (HAD superfamily) General function prediction only 127512675 Common - hypothetical protein Shew_1746 1 None None None 127514555 Common - transcriptional regulator, XRE family Shew_3627 69 COG1476 COG1476, Predicted transcriptional regulators Transcription 127513500 Common - Enoyl-CoA hydratase/isomerase Shew_2572 178 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 127512528 Common rpmF 50S ribosomal protein L32 Shew_1599 65 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 127513628 Common - Antibiotic biosynthesis monooxygenase Shew_2700 7 COG1359 COG1359, Uncharacterized conserved protein Function unknown 127513668 Common - YfaZ family protein Shew_2740 13 None None None 127512668 Common - DoxX family protein Shew_1739 38 COG2259 COG2259, Predicted membrane protein Function unknown 127512646 Common - globin Shew_1717 27 COG1017 Hmp, Hemoglobin-like flavoprotein Energy production and conversion 127512193 Common - type III restriction enzyme, res subunit Shew_1261 15 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 127511623 Common - hypothetical protein Shew_0689 1 None None None 127512403 Common - peptidase M23B Shew_1474 183 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 127511430 Common - amino acid carrier protein Shew_0496 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 127512615 Common - hypothetical protein Shew_1686 3 None None None 127514110 Common - hypothetical protein Shew_3182 6 None None None 127511213 Nonpathogen - hypothetical protein Shew_0279 1 None None None 127513465 Common - transcriptional regulator, AraC family Shew_2537 110 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 127512971 Common - cation diffusion facilitator family transporter Shew_2043 142 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 127511860 Common - Amidohydrolase 3 Shew_0927 110 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 127514190 Common - hypothetical protein Shew_3262 1 None None None 127512763 Common - glutaredoxin-like protein Shew_1835 126 COG0278 COG0278, Glutaredoxin-related protein Posttranslational modification, protein turnover, chaperones 127511974 Common thyA thymidylate synthase Shew_1041 136 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 127512780 Common - acriflavin resistance protein Shew_1852 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 127513217 Common - Glycosyl hydrolase family 98, putative carbohydrate binding module Shew_2289 14 None None None 127513685 Common - hypothetical protein Shew_2757 5 None None None 127511829 Common - two component transcriptional regulator, winged helix family Shew_0896 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127514261 Common - electron transport protein SCO1/SenC Shew_3333 99 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 127513942 Common - gamma-glutamyl kinase Shew_3014 192 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 127514445 Common - Histidine ammonia-lyase Shew_3517 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 127511899 Common - beta alanine--pyruvate transaminase Shew_0966 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 127513435 Common clpX ATP-dependent protease ATP-binding subunit Shew_2507 233 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 127513395 Common - protein of unknown function DUF1260 Shew_2467 7 None None None 127513132 Common - phosphoribosyl-AMP cyclohydrolase Shew_2204 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 127514714 Nonpathogen - hypothetical protein Shew_3786 1 None None None 127511967 Common - Hpt protein Shew_1034 22 COG2198 ArcB, FOG: HPt domain Signal transduction mechanisms 127514300 Common - Arginase/agmatinase/formiminoglutamase Shew_3372 30 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 127510957 Common - potassium uptake protein, TrkH family Shew_0022 120 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 127512471 Common - major facilitator superfamily MFS_1 Shew_1542 110 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 127512742 Common - ABC transporter ATPase component Shew_1814 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 127511834 Common - Transketolase, central region Shew_0901 179 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 127513932 Common - protein of unknown function DUF224, cysteine-rich region domain protein Shew_3004 144 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 127512576 Common - acriflavin resistance protein Shew_1647 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 127512058 Common - hypothetical protein Shew_1125 25 COG3171 COG3171, Uncharacterized protein conserved in bacteria Function unknown 127510994 Common - molybdopterin oxidoreductase Shew_0059 191 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 127511501 Common - GTP-binding protein, HSR1-related Shew_0567 233 COG2262 HflX, GTPases General function prediction only 127514140 Common - cell division protein ZipA Shew_3212 12 COG0645 COG0645, Predicted kinase General function prediction only 127512424 Common - hypothetical protein Shew_1495 35 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 127512452 Common - 4-hydroxybenzoyl-CoA thioesterase Shew_1523 137 COG0824 FcbC, Predicted thioesterase General function prediction only 127512219 Common - hypothetical protein Shew_1287 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 127512118 Common - hypothetical protein Shew_1186 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 127511044 Common - MCP methyltransferase, CheR-type Shew_0110 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 127512628 Common - phosphate ABC transporter, inner membrane subunit PstA Shew_1699 225 COG4985 COG4985, ABC-type phosphate transport system, auxiliary component Inorganic ion transport and metabolism 127512117 Common glyA serine hydroxymethyltransferase Shew_1185 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 127512396 Common - diguanylate cyclase Shew_1467 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127513150 Common - hypothetical protein Shew_2222 7 None None None 127512914 Common - cytochrome c oxidase, cbb3-type, subunit II Shew_1986 82 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 127511857 Common - DNA polymerase III chi subunit, HolC Shew_0924 58 COG2927 HolC, DNA polymerase III, chi subunit DNA replication, recombination, and repair 127513761 Common - dihydropteroate synthase Shew_2833 218 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 127511281 Common - cytochrome c assembly protein Shew_0347 131 COG1138 CcmF, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 127511617 Common - secretion protein HlyD family protein Shew_0683 164 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 127513825 Common - transcriptional regulator, LysR family Shew_2897 173 COG0583 LysR, Transcriptional regulator Transcription 127512162 Common - phosphoribosylaminoimidazole carboxylase, catalytic subunit Shew_1230 232 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 127511435 Common - protein of unknown function DUF134 Shew_0501 41 COG1342 COG1342, Predicted DNA-binding proteins General function prediction only 127514073 Nonpathogen - hypothetical protein Shew_3145 2 None None None 127513053 Common - Lytic transglycosylase, catalytic Shew_2125 164 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 127511655 Common - efflux transporter, RND family, MFP subunit Shew_0721 125 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 127511879 Common - band 7 protein Shew_0946 45 COG2268 COG2268, Uncharacterized protein conserved in bacteria Function unknown 127514504 Common - cysteine dioxygenase type I Shew_3576 21 COG5553 COG5553, Predicted metal-dependent enzyme of the double-stranded beta helix superfamily General function prediction only 127511083 Common rplJ 50S ribosomal protein L10 Shew_0149 205 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 127511499 Common - tRNA delta(2)-isopentenylpyrophosphate transferase Shew_0565 214 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 127512665 Common - hypothetical protein Shew_1736 9 None None None 127512723 Common - diguanylate cyclase Shew_1795 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127512108 Common - SEC-C motif domain protein Shew_1176 13 None None None 127512487 Common - adenylosuccinate lyase Shew_1558 232 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 127513776 Common - gamma-glutamyl kinase Shew_2848 189 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 127511415 Nonpathogen - hypothetical protein Shew_0481 1 None None None 127513058 Common - exodeoxyribonuclease V, beta subunit Shew_2130 218 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 127514759 Common - putative hydrolase Shew_3832 43 COG2015 COG2015, Alkyl sulfatase and related hydrolases Secondary metabolites biosynthesis, transport, and catabolism 127514153 Common - glutathione synthetase Shew_3225 121 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 127512715 Common - putative chaperone Shew_1787 65 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 127512324 Common - FlhB domain protein Shew_1393 41 COG2257 COG2257, Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB Function unknown 127512830 Common - NUDIX hydrolase Shew_1902 130 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 127514212 Common rpsF 30S ribosomal protein S6 Shew_3284 195 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 127513656 Common - hypothetical protein Shew_2728 24 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 127512571 Common - Peptidase M11, gametolysin Shew_1642 39 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 127514407 Common rpmG 50S ribosomal protein L33 Shew_3479 137 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 127513344 Common - chorismate synthase Shew_2416 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 127511551 Common - phosphate transporter Shew_0617 173 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 127514013 Common - Lipocalin family protein Shew_3085 67 COG3040 Blc, Bacterial lipocalin Cell envelope biogenesis, outer membrane 127511154 Common - phosphoglycolate phosphatase Shew_0220 204 COG0546 Gph, Predicted phosphatases General function prediction only 127514708 Common - TAP domain protein Shew_3780 40 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 127511661 Common - integral membrane sensor signal transduction histidine kinase Shew_0727 196 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 127512268 Common - hypothetical protein Shew_1337 11 None None None 127511632 Common - Na+/H+ antiporter NhaC Shew_0698 54 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 127512877 Common - DNA gyrase, A subunit Shew_1949 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 127512937 Common - hypothetical protein Shew_2009 6 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 127514762 Common - hypothetical protein Shew_3837 4 None None None 127513174 Common - pseudouridine synthase Shew_2246 205 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 127514437 Common - hypothetical protein Shew_3509 35 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127511335 Common - MSHA biogenesis protein MshP Shew_0401 9 None None None 127510965 Common - hypothetical protein Shew_0030 24 None None None 127513841 Common hemA glutamyl-tRNA reductase Shew_2913 181 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 127513315 Common - transcriptional regulator, LysR family Shew_2387 171 COG0583 LysR, Transcriptional regulator Transcription 127514701 Common - hypothetical protein Shew_3773 3 None None None 127513320 Common - protein of unknown function DUF412 Shew_2392 22 COG3092 COG3092, Uncharacterized protein conserved in bacteria Function unknown 127511848 Common - putative transcriptional regulator Shew_0915 47 COG2345 COG2345, Predicted transcriptional regulator Transcription 127512950 Common - recombination factor protein RarA Shew_2022 237 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 127514599 Nonpathogen - hypothetical protein Shew_3671 2 None None None 127514008 Common - thiol:disulfide interchange protein, putative Shew_3080 53 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 127512144 Common - peptidase M23B Shew_1212 189 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 127513982 Common - hypothetical protein Shew_3054 16 None None None 127510997 Common - hypothetical protein Shew_0062 1 None None None 127511439 Common - Nitrite reductase (cytochrome; ammonia-forming) Shew_0505 40 COG3303 NrfA, Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit Inorganic ion transport and metabolism 127513507 Common - thymidine kinase Shew_2579 97 COG1435 Tdk, Thymidine kinase Nucleotide transport and metabolism 127514162 Nonpathogen - hypothetical protein Shew_3234 3 None None None 127513962 Common - diguanylate cyclase Shew_3034 175 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 127512653 Common - cytochrome c3 Shew_1724 1 None None None 127514127 Common - response regulator receiver modulated metal dependent phosphohydrolase Shew_3199 225 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 127513634 Common - Na(+)-translocating NADH-quinone reductase subunit D Shew_2706 76 COG1347 NqrD, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD Energy production and conversion 127511852 Common - diguanylate phosphodiesterase Shew_0919 171 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 127511225 Common - branched-chain amino acid aminotransferase Shew_0291 221 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 127511544 Common - integral membrane sensor signal transduction histidine kinase Shew_0610 195 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 127513442 Common - tRNA--hydroxylase Shew_2514 40 COG4445 MiaE, Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 127514273 Common - lipid kinase Shew_3345 101 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 127514377 Common - cell division protein FtsZ Shew_3449 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 127513848 Common - peptidyl-tRNA hydrolase Shew_2920 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 127511703 Common - branched-chain amino acid transport system II carrier protein Shew_0769 50 COG1114 BrnQ, Branched-chain amino acid permeases Amino acid transport and metabolism 127513107 Nonpathogen - hypothetical protein Shew_2179 5 None None None 127511295 Common - hypothetical protein Shew_0361 1 None None None 127514565 Common ompR osmolarity response regulator Shew_3637 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127513636 Common - Na(+)-translocating NADH-quinone reductase subunit B Shew_2708 75 COG1805 NqrB, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB Energy production and conversion 127512245 Common - hypothetical protein Shew_1314 2 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 127511049 Nonpathogen - hypothetical protein Shew_0115 1 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 127510983 Common - short chain dehydrogenase Shew_0048 227 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 127513525 Nonpathogen - hypothetical protein Shew_2597 2 None None None 127514282 Common - aminotransferase, class V Shew_3354 236 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 127512336 Common - glycosyl transferase, group 1 Shew_1405 29 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 127511367 Nonpathogen - hypothetical protein Shew_0433 1 None None None 127510967 Common - transporter, hydrophobe/amphiphile efflux-1 (HAE1) family Shew_0032 179 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 127512429 Common - putative signal transduction protein with CBS domains Shew_1500 48 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 127514176 Common - hypothetical protein Shew_3248 2 None None None 127512085 Common - MscS Mechanosensitive ion channel Shew_1152 207 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 127512704 Common - acetolactate synthase 3 catalytic subunit Shew_1776 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 127511075 Common - UDP-N-acetylenolpyruvoylglucosamine reductase Shew_0141 200 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 127512805 Common - glutathione-dependent formaldehyde-activating, GFA Shew_1877 64 COG3791 COG3791, Uncharacterized conserved protein Function unknown 127514052 Common - ATP-dependent helicase HrpB Shew_3124 131 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 127513128 Common - imidazole glycerol-phosphate dehydratase/histidinol phosphatase Shew_2200 218 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 127511236 Common - phosphoesterase, PA-phosphatase related Shew_0302 18 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 127512364 Common phhA phenylalanine 4-monooxygenase Shew_1435 45 COG3186 COG3186, Phenylalanine-4-hydroxylase Amino acid transport and metabolism 127511365 Common - hypothetical protein Shew_0431 1 None None None 127511163 Common - extracellular solute-binding protein, family 3 Shew_0229 11 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 127514218 Common - Sel1 domain protein repeat-containing protein Shew_3290 33 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 127512856 Common - quinolinate synthetase Shew_1928 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 127514424 Common - hypothetical protein Shew_3496 2 None None None 127514627 Common - glycosyl transferase, family 2 Shew_3699 65 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 127514747 Common - transcriptional regulator, MerR family Shew_3819 136 COG0789 SoxR, Predicted transcriptional regulators Transcription 127513472 Common - phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I Shew_2544 240 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 127511979 Common - hypothetical protein Shew_1046 1 None None None 127511534 Nonpathogen - hypothetical protein Shew_0600 1 None None None 127514387 Common - Peptidoglycan glycosyltransferase Shew_3459 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 127513904 Common - hypothetical protein Shew_2976 1 None None None 127514400 Common - 2-isopropylmalate synthase Shew_3472 217 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 127513085 Common - protein of unknown function DUF482 Shew_2157 81 COG3146 COG3146, Uncharacterized protein conserved in bacteria Function unknown 127514624 Nonpathogen - CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase Shew_3696 1 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 127512101 Common - glycogen debranching enzyme GlgX Shew_1169 168 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 127511508 Common - ClpXP protease specificity-enhancing factor Shew_0574 64 COG2969 SspB, Stringent starvation protein B General function prediction only 127512040 Common - methylation site containing protein Shew_1107 71 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 127514396 Common - membrane protein involved in aromatic hydrocarbon degradation Shew_3468 82 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 127513237 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Shew_2309 230 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 127513129 Common hisH imidazole glycerol phosphate synthase subunit HisH Shew_2201 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 127514098 Common - sodium/hydrogen exchanger Shew_3170 106 COG3263 COG3263, NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain Inorganic ion transport and metabolism 127514091 Common - diguanylate cyclase with PAS/PAC sensor Shew_3163 187 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127512840 Common - deoxyguanosinetriphosphate triphosphohydrolase-like protein Shew_1912 160 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 127514245 Common - two component transcriptional regulator, winged helix family Shew_3317 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127511208 Common - hypothetical protein Shew_0274 17 None None None 127513369 Common - hypothetical protein Shew_2441 40 None None None 127513488 Common - transcriptional regulator, XRE family Shew_2560 12 COG1396 HipB, Predicted transcriptional regulators Transcription 127513440 Common - Peptidylprolyl isomerase Shew_2512 201 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 127513384 Common - SMC domain protein Shew_2456 120 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 127511465 Common - DEAD/DEAH box helicase domain protein Shew_0531 234 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 127511064 Common - 3'(2'),5'-bisphosphate nucleotidase Shew_0130 197 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 127513295 Common - hypothetical protein Shew_2367 3 None None None 127511593 Common - bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase Shew_0659 151 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 127512133 Common rumA 23S rRNA 5-methyluridine methyltransferase Shew_1201 203 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 127512518 Common rbgA ribosomal biogenesis GTPase Shew_1589 98 COG1161 COG1161, Predicted GTPases General function prediction only 127512233 Common - phosphoribosylformylglycinamidine synthase Shew_1301 233 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 127513583 Common - hypothetical protein Shew_2655 15 None None None 127513663 Common - Patatin Shew_2735 59 COG4667 COG4667, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 127511449 Common - hypothetical protein Shew_0515 9 None None None 127513277 Common - integral membrane sensor signal transduction histidine kinase Shew_2349 216 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127514082 Common - transcriptional regulator, LysR family Shew_3154 35 COG0583 LysR, Transcriptional regulator Transcription 127514323 Common - Radical SAM domain protein Shew_3395 35 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 127514435 Common - ATP-dependent DNA helicase RecG Shew_3507 234 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 127513287 Common - Uracil-DNA glycosylase superfamily Shew_2359 62 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 127513925 Common - acetyltransferase-like protein Shew_2997 31 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 127511546 Nonpathogen - hypothetical protein Shew_0612 1 None None None 127512627 Common - binding-protein-dependent transport systems inner membrane component Shew_1698 221 COG4590 COG4590, ABC-type uncharacterized transport system, permease component General function prediction only 127510946 Common - DNA-3-methyladenine glycosylase I Shew_0011 132 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 127512906 Common - hypothetical protein Shew_1978 62 COG1073 COG1073, Hydrolases of the alpha/beta superfamily General function prediction only 127514466 Common - hypothetical protein Shew_3538 1 None None None 127512640 Common - conserved hypothetical methyl-accepting chemotaxis protein Shew_1711 3 None None None 127514050 Common - PepSY-associated TM helix domain protein Shew_3122 5 COG3295 COG3295, Uncharacterized protein conserved in bacteria Function unknown 127511649 Common - cobalamin 5'-phosphate synthase Shew_0715 122 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 127512559 Common - transcription-repair coupling factor Shew_1630 236 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 127511185 Common - phage integrase family protein Shew_0251 38 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 127513573 Common - hypothetical protein Shew_2645 10 None None None 127511760 Common - protein of unknown function DUF808 Shew_0826 61 COG2354 COG2354, Uncharacterized protein conserved in bacteria Function unknown 127511195 Common - hypothetical protein Shew_0261 1 None None None 127513767 Common - carbamoyl phosphate synthase small subunit Shew_2839 234 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 127511244 Common - type I secretion outer membrane protein, TolC family Shew_0310 124 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 127512741 Common - glutaredoxin 2 Shew_1813 17 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 127511314 Common - hypothetical protein Shew_0380 1 COG3170 FimV, Tfp pilus assembly protein FimV Cell motility and secretion / Intracellular trafficking and secretion 127513111 Common - protein of unknown function DUF709 Shew_2183 34 COG3100 COG3100, Uncharacterized protein conserved in bacteria Function unknown 127512075 Common - putative transcriptional regulator Shew_1142 67 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 127512647 Common - adenosylmethionine-8-amino-7-oxononanoate aminotransferase Shew_1718 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 127514226 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase Shew_3298 219 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 127511492 Common - ribosome-associated GTPase Shew_0558 163 COG1162 COG1162, Predicted GTPases General function prediction only 127512036 Common - type IV pilus modification protein PilV Shew_1103 9 COG4967 PilV, Tfp pilus assembly protein PilV Cell motility and secretion / Intracellular trafficking and secretion 127512344 Nonpathogen - hypothetical protein Shew_1413 1 None None None 127511670 Common - aldo/keto reductase Shew_0736 198 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 127511493 Common - oligoribonuclease Shew_0559 88 COG1949 Orn, Oligoribonuclease (3'->5' exoribonuclease) RNA processing and modification 127513569 Common - PTS system, glucose-like IIB subunint Shew_2641 49 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 127511471 Common - hypothetical protein Shew_0537 1 None None None 127512103 Common - glucose-1-phosphate adenylyltransferase Shew_1171 130 COG0448 GlgC, ADP-glucose pyrophosphorylase Carbohydrate transport and metabolism 127513425 Common - sigma54 specific transcriptional regulator, Fis family Shew_2497 168 COG1221 PspF, Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain Transcription / Signal transduction mechanisms 127512195 Common - hypothetical protein Shew_1263 5 COG4469 CoiA, Competence protein General function prediction only 127513975 Common - conserved hypothetical signal peptide protein Shew_3047 67 COG1073 COG1073, Hydrolases of the alpha/beta superfamily General function prediction only 127513260 Common - siroheme synthase Shew_2332 146 COG1648 CysG, Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) Coenzyme metabolism 127510976 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Shew_0041 191 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 127511125 Common - cytochrome c, class I Shew_0191 45 COG3245 CycB, Cytochrome c5 Energy production and conversion 127513803 Common - ApbE family lipoprotein Shew_2875 139 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 127511376 Common - aldo/keto reductase Shew_0442 179 COG4989 COG4989, Predicted oxidoreductase General function prediction only 127511642 Nonpathogen - hypothetical protein Shew_0708 1 None None None 127511275 Common - TonB-dependent receptor Shew_0341 104 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 127513497 Common - transcriptional regulator, MerR family Shew_2569 53 COG0789 SoxR, Predicted transcriptional regulators Transcription 127514255 Common - RNA-metabolising metallo-beta-lactamase Shew_3327 128 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 127511733 Common - transcriptional regulator, MarR family Shew_0799 124 COG1846 MarR, Transcriptional regulators Transcription 127512849 Common - replication initiation regulator SeqA Shew_1921 23 COG3057 SeqA, Negative regulator of replication initiationR DNA replication, recombination, and repair 127513832 Common - 2-dehydro-3-deoxyphosphooctonate aldolase Shew_2904 186 COG2877 KdsA, 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase Cell envelope biogenesis, outer membrane 127514440 Common - acyl carrier protein Shew_3512 85 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127512503 Common - ATP-binding protein, Mrp/Nbp35 family Shew_1574 229 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 127514769 Common - ATP synthase F1, epsilon subunit Shew_3844 178 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 127513771 Common - chaperone protein DnaJ Shew_2843 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 127514367 Common - type II secretion system protein Shew_3439 142 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 127514736 Common - carboxyl-terminal protease Shew_3808 181 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 127514597 Common - ThiJ/PfpI domain protein Shew_3669 72 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 127511667 Common - hypothetical protein Shew_0733 23 COG3907 COG3907, PAP2 (acid phosphatase) superfamily protein General function prediction only 127512096 Common - transporter, hydrophobe/amphiphile efflux-1 (HAE1) family Shew_1164 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 127513015 Common - hypothetical protein Shew_2087 3 None None None 127513918 Common - TonB-dependent receptor Shew_2990 123 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 127511680 Common - diguanylate cyclase Shew_0746 4 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127511673 Common - aromatic amino acid permease Shew_0739 39 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 127512220 Common - type IV pilus biogenesis/stability protein PilW Shew_1288 90 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 127512511 Common - hydrolase, TatD family Shew_1582 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 127512944 Common - DsrE family protein Shew_2016 38 COG2923 DsrF, Uncharacterized protein involved in the oxidation of intracellular sulfur Inorganic ion transport and metabolism 127511251 Common - Uroporphyrinogen III synthase HEM4 Shew_0317 67 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 127512725 Common - Paraquat-inducible protein A Shew_1797 54 COG2995 PqiA, Uncharacterized paraquat-inducible protein A Function unknown 127512467 Common - hypothetical protein Shew_1538 12 COG2841 COG2841, Uncharacterized protein conserved in bacteria Function unknown 127512994 Common - Na(+)-translocating NADH-quinone reductase subunit E Shew_2066 76 COG4657 RnfA, Predicted NADH:ubiquinone oxidoreductase, subunit RnfA Energy production and conversion 127512353 Common - TrkA-C domain protein Shew_1424 103 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 127513118 Common - hypothetical protein Shew_2190 21 COG4798 COG4798, Predicted methyltransferase General function prediction only 127513534 Common - ABC transporter-related protein Shew_2606 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 127513262 Common secF preprotein translocase subunit SecF Shew_2334 202 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 127513370 Common - Rhodanese domain protein Shew_2442 119 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 127514170 Common - transcriptional regulator, LysR family Shew_3242 55 COG0583 LysR, Transcriptional regulator Transcription 127512611 Common - ribonuclease H Shew_1682 170 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 127513614 Common - putative lipoprotein Shew_2686 11 None None None 127511581 Nonpathogen - hypothetical protein Shew_0647 1 None None None 127514560 Common - sulfatase Shew_3632 74 COG1368 MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily Cell envelope biogenesis, outer membrane 127514635 Common - Three-deoxy-D-manno-octulosonic-acid transferase domain protein Shew_3707 128 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 127511094 Common rplW 50S ribosomal protein L23 Shew_0160 118 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 127513894 Common - membrane-flanked domain protein Shew_2966 9 COG3428 COG3428, Predicted membrane protein Function unknown 127513671 Common - Microbial collagenase Shew_2743 14 None None None 127511608 Common - major facilitator superfamily MFS_1 Shew_0674 17 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 127511257 Common dapF diaminopimelate epimerase Shew_0323 203 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 127511750 Common - hypothetical protein Shew_0816 20 COG5637 COG5637, Predicted integral membrane protein Function unknown 127514728 Common - hypothetical protein Shew_3800 7 None None None 127513727 Common torD chaperone protein TorD Shew_2799 25 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 127513885 Common - hypothetical protein Shew_2957 1 None None None 127514270 Common - two component transcriptional regulator, Fis family Shew_3342 216 COG4567 COG4567, Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain Signal transduction mechanisms / Transcription 127513029 Common - hypothetical protein Shew_2101 32 None None None 127512821 Common - protein of unknown function UPF0047 Shew_1893 131 COG0432 COG0432, Uncharacterized conserved protein Function unknown 127511096 Common rpsS 30S ribosomal protein S19 Shew_0162 246 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 127511687 Common - D-erythrose-4-phosphate dehydrogenase Shew_0753 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 127512694 Common - putative signal transduction protein with CBS domains Shew_1766 68 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 127514496 Common - cation diffusion facilitator family transporter Shew_3568 195 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 127511351 Common - transcriptional regulator, ArsR family Shew_0417 141 COG0640 ArsR, Predicted transcriptional regulators Transcription 127512210 Common - hypothetical protein Shew_1278 6 None None None 127514020 Common - membrane-flanked domain protein Shew_3092 30 COG3428 COG3428, Predicted membrane protein Function unknown 127512988 Common - Pyridoxal-5'-phosphate-dependent enzyme, beta subunit Shew_2060 216 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 127511258 Common - protein of unknown function DUF484 Shew_0324 51 COG3159 COG3159, Uncharacterized protein conserved in bacteria Function unknown 127512016 Common - apurinic endonuclease Apn1 Shew_1083 100 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 127512710 Common - transcriptional regulator, MarR family Shew_1782 65 COG1846 MarR, Transcriptional regulators Transcription 127512910 Common - phage integrase family protein Shew_1982 63 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 127512673 Common - GCN5-related N-acetyltransferase Shew_1744 111 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 127511036 Nonpathogen - hypothetical protein Shew_0102 1 None None None 127512299 Common - flagellar assembly protein FliH Shew_1368 52 COG1317 FliH, Flagellar biosynthesis/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 127514574 Nonpathogen - hypothetical protein Shew_3646 1 None None None 127512305 Common fliN flagellar motor switch protein Shew_1374 122 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 127514003 Common - hypothetical protein Shew_3075 1 None None None 127512787 Common - Carbonate dehydratase Shew_1859 151 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 127514152 Common - hypothetical protein Shew_3224 207 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 127511945 Common - glutamate-1-semialdehyde-2,1-aminomutase Shew_1012 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 127513143 Common pheT phenylalanyl-tRNA synthetase subunit beta Shew_2215 246 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 127514351 Common - anti-RNA polymerase sigma 70 factor Shew_3423 24 COG3160 Rsd, Regulator of sigma D Transcription 127514480 Common - transposase IS116/IS110/IS902 family protein Shew_3552 88 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 127513077 Common - conserved hypothetical ABC transporter protein Shew_2149 10 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 127511905 Common - Glutamate--ammonia ligase Shew_0972 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 127513153 Common - succinylarginine dihydrolase Shew_2225 34 COG3724 AstB, Succinylarginine dihydrolase Amino acid transport and metabolism 127513745 Common - nucleoside transporter Shew_2817 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 127514089 Common - hypothetical protein Shew_3161 3 None None None 127514529 Common - O-succinylbenzoate synthase Shew_3601 53 COG1441 MenC, O-succinylbenzoate synthase Coenzyme metabolism 127512597 Common - methylmalonate-semialdehyde dehydrogenase Shew_1668 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 127513036 Common fadE acyl-CoA dehydrogenase Shew_2108 147 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 127512562 Common - lipoprotein releasing system, ATP-binding protein Shew_1633 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 127511885 Common - peptidase M24 Shew_0952 228 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 127512262 Common - Spore coat polysaccharide biosynthesis protein predicted glycosyltransferase-like Shew_1331 15 COG3980 spsG, Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase Cell envelope biogenesis, outer membrane 127514390 Common - hypothetical protein Shew_3462 137 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 127514414 Common folE GTP cyclohydrolase I Shew_3486 176 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 127513433 Common - histone family protein DNA-binding protein Shew_2505 212 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 127514514 Common - DTW domain containing protein Shew_3586 38 COG3148 COG3148, Uncharacterized conserved protein Function unknown 127511006 Common - transcriptional regulator, AraC family Shew_0071 148 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 127512874 Common - ribonucleotide-diphosphate reductase subunit alpha Shew_1946 210 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 127512798 Common - transcriptional regulator, LacI family Shew_1870 128 COG1609 PurR, Transcriptional regulators Transcription 127514540 Common - General secretion pathway protein K Shew_3612 40 COG3156 PulK, Type II secretory pathway, component PulK Intracellular trafficking and secretion 127511813 Common ksgA dimethyladenosine transferase Shew_0879 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 127514588 Common - glutathione reductase Shew_3660 247 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 127512394 Common - hypothetical protein Shew_1465 4 None None None 127511324 Common - MSHA biogenesis protein MshM Shew_0390 68 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 127511407 Nonpathogen - hypothetical protein Shew_0473 1 None None None 127512154 Common - hypothetical protein Shew_1222 3 None None None 127514472 Common - alpha/beta hydrolase fold Shew_3544 94 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 127513643 Common - protein of unknown function DUF599 Shew_2715 26 COG3821 COG3821, Predicted membrane protein Function unknown 127513254 Common - RepA domain protein Shew_2326 2 None None None 127512441 Common - phosphoribosylglycinamide formyltransferase Shew_1512 224 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 127512294 Common - PAS/PAC sensor signal transduction histidine kinase Shew_1363 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127512221 Common - hypothetical protein Shew_1289 84 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 127514451 Common - 3-oxoacyl-(acyl carrier protein) synthase I Shew_3523 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127514678 Common - phospholipid/glycerol acyltransferase Shew_3750 45 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 127511640 Common - short-chain dehydrogenase/reductase SDR Shew_0706 177 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 127512156 Common - sodium:dicarboxylate symporter Shew_1224 164 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 127511654 Common - hypothetical protein Shew_0720 33 COG3686 COG3686, Predicted membrane protein Function unknown 127512569 Common - protein of unknown function DUF343 Shew_1640 98 COG2835 COG2835, Uncharacterized conserved protein Function unknown 127512314 Common fliA flagellar biosynthesis sigma factor Shew_1383 216 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 127513357 Common - hypothetical protein Shew_2429 8 None None None 127512207 Common - malate synthase Shew_1275 73 COG2225 AceB, Malate synthase Energy production and conversion 127514107 Common - hypothetical protein Shew_3179 1 None None None 127511763 Common - LrgA family protein Shew_0829 24 COG1380 COG1380, Putative effector of murein hydrolase LrgA General function prediction only 127514029 Common - UspA domain protein Shew_3101 100 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 127512554 Common - L-serine dehydratase 1 Shew_1625 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 127512458 Common - Tetratricopeptide TPR_2 repeat protein Shew_1529 91 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 127511232 Common - Zn-dependent hydrolase of the beta-lactamase fold Shew_0298 101 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 127512121 Common - 3,4-dihydroxy-2-butanone 4-phosphate synthase Shew_1189 229 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 127513469 Common - Helix-turn-helix, type 11 domain protein Shew_2541 102 COG2378 COG2378, Predicted transcriptional regulator Transcription 127511723 Common - Mg2+ transporter protein, CorA family protein Shew_0789 181 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 127513379 Common - Patatin Shew_2451 128 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 127513360 Common - hypothetical protein Shew_2432 30 None None None 127512768 Common - arsenate reductase Shew_1840 115 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 127513798 Common - TonB-dependent receptor Shew_2870 66 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 127514209 Common rplI 50S ribosomal protein L9 Shew_3281 206 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 127511468 Common - major facilitator superfamily MFS_1 Shew_0534 107 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 127511954 Common - peptidase M23B Shew_1021 181 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 127513878 Common - pseudouridine synthase, RluA family Shew_2950 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 127514661 Common - protein of unknown function DUF494 Shew_3733 39 COG2922 Smg, Uncharacterized protein conserved in bacteria Function unknown 127513515 Common - hypothetical protein Shew_2587 39 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 127512546 Common - protein of unknown function DUF480 Shew_1617 41 COG3132 COG3132, Uncharacterized protein conserved in bacteria Function unknown 127514278 Common - hypothetical protein Shew_3350 14 None None None 127512901 Common - porin, Gram-negative type Shew_1973 24 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 127511358 Common - amino acid carrier protein Shew_0424 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 127512867 Common - protein of unknown function DUF1315 Shew_1939 20 COG3139 COG3139, Uncharacterized protein conserved in bacteria Function unknown 127513817 Common - uncharacterized lipoprotein Shew_2889 17 COG3056 COG3056, Uncharacterized lipoprotein Cell envelope biogenesis, outer membrane 127511424 Common - peptidase S9, prolyl oligopeptidase active site domain protein Shew_0490 110 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 127513873 Common - CDP-diacylglycerol--serine O-phosphatidyltransferase Shew_2945 142 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 127511142 Common - type IV pilus assembly protein PilM Shew_0208 80 COG4972 PilM, Tfp pilus assembly protein, ATPase PilM Cell motility and secretion / Intracellular trafficking and secretion 127511992 Common - protein of unknown function DUF962 Shew_1059 27 COG4539 COG4539, Predicted membrane protein Function unknown 127513715 Common - peptidase U32 Shew_2787 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 127511109 Common rpsE 30S ribosomal protein S5 Shew_0175 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 127512217 Common - 5'-nucleotidase Shew_1285 112 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 127511374 Common - Methyltransferase type 12 Shew_0440 62 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 127510939 Common - DNA gyrase, B subunit Shew_0004 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 127513502 Common - pyruvate carboxyltransferase Shew_2574 177 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 127512171 Common - PepSY-associated TM helix domain protein Shew_1239 28 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 127512055 Common - hypothetical protein Shew_1122 72 COG2924 COG2924, Uncharacterized protein conserved in bacteria Function unknown 127510986 Common - cyclic nucleotide-binding protein Shew_0051 112 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 127511149 Common - Sporulation domain protein Shew_0215 2 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 127514201 Common - hypothetical protein Shew_3273 1 None None None 127511175 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Shew_0241 170 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 127512349 Common - putative hydrolase Shew_1420 79 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 127513676 Common - PAS/PAC sensor signal transduction histidine kinase Shew_2748 218 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 127511913 Common - multi-sensor hybrid histidine kinase Shew_0980 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127513959 Common - phosphoesterase, PA-phosphatase related Shew_3031 13 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 127513553 Common - UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase Shew_2625 150 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 127514666 Common - sun protein Shew_3738 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 127514238 Common - ABC transporter-related protein Shew_3310 249 COG1137 YhbG, ABC-type (unclassified) transport system, ATPase component General function prediction only 127512538 Common - 6-phosphogluconate dehydrogenase, NAD-binding Shew_1609 194 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 127511984 Common - positive regulator of sigma E, RseC/MucC Shew_1051 19 COG3086 RseC, Positive regulator of sigma E activity Signal transduction mechanisms 127514790 Common trmE tRNA modification GTPase TrmE Shew_3865 230 COG0486 ThdF, Predicted GTPase General function prediction only 127511959 Common - cobalamin biosynthesis protein CbiB Shew_1026 74 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 127512369 Common - transcriptional regulator, LysR family Shew_1440 192 COG0583 LysR, Transcriptional regulator Transcription 127512278 Common flgD flagellar basal body rod modification protein Shew_1347 107 COG1843 FlgD, Flagellar hook capping protein Cell motility and secretion 127513658 Common - Glutathione S-transferase, C-terminal domain Shew_2730 80 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 127513706 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Shew_2778 196 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 127512216 Common - GCN5-related N-acetyltransferase Shew_1284 31 COG0456 RimI, Acetyltransferases General function prediction only 127513127 Common - histidinol-phosphate aminotransferase Shew_2199 229 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 127512648 Common - biotin synthase Shew_1719 178 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 127511130 Common - Redoxin domain protein Shew_0196 139 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 127511612 Common - protoporphyrinogen oxidase Shew_0678 34 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 127514289 Common - hypothetical protein Shew_3361 2 None None None 127511788 Common - hypothetical protein Shew_0854 1 None None None 127512300 Common fliI flagellum-specific ATP synthase Shew_1369 247 COG1157 FliI, Flagellar biosynthesis/type III secretory pathway ATPase Cell motility and secretion / Intracellular trafficking and secretion 127513533 Common - putative phenylacetate-coenzyme A ligase Shew_2605 100 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 127512149 Common - alanyl-tRNA synthetase Shew_1217 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 127513501 Common - Carbamoyl-phosphate synthase L chain, ATP-binding Shew_2573 236 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 127513639 Common - transcriptional regulator, AraC family Shew_2711 91 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 127511484 Common - L-sorbosone dehydrogenase, putative Shew_0550 72 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 127513101 Common - protein of unknown function DUF490 Shew_2173 93 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 127513230 Common - amidophosphoribosyltransferase Shew_2302 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 127513416 Common - hypothetical protein Shew_2488 11 None None None 127514330 Common - ABC transporter-related protein Shew_3402 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 127512309 Common fliR flagellar biosynthesis protein FliR Shew_1378 128 COG1684 FliR, Flagellar biosynthesis pathway, component FliR Cell motility and secretion / Intracellular trafficking and secretion 127511784 Common - hypothetical protein Shew_0850 11 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 127512362 Common - UDP-glucose 4-epimerase Shew_1433 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 127513239 Common - protein of unknown function DUF528 Shew_2311 43 COG2975 COG2975, Uncharacterized protein conserved in bacteria Function unknown 127513313 Common - TonB-dependent receptor, plug Shew_2385 117 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 127512460 Common grxA glutaredoxin 1 Shew_1531 36 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 127512767 Common - hypothetical protein Shew_1839 7 COG3308 COG3308, Predicted membrane protein Function unknown 127512499 Common - 17 kDa surface antigen Shew_1570 6 COG3133 SlyB, Outer membrane lipoprotein Cell envelope biogenesis, outer membrane 127511363 Common - hypothetical protein Shew_0429 38 None None None 127512492 Common - isocitrate dehydrogenase, NADP-dependent Shew_1563 65 COG2838 Icd, Monomeric isocitrate dehydrogenase Energy production and conversion 127513307 Common - chromosome segregation protein SMC Shew_2379 186 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 127514074 Nonpathogen - hypothetical protein Shew_3146 1 None None None 127513158 Common - adenylate kinase Shew_2230 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 127514703 Common - thioesterase superfamily protein Shew_3775 38 COG0824 FcbC, Predicted thioesterase General function prediction only 127511683 Common - hypothetical protein Shew_0749 1 None None None 127514285 Common - efflux transporter, RND family, MFP subunit Shew_3357 119 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 127514371 Common - protein of unknown function DUF329 Shew_3443 63 COG3024 COG3024, Uncharacterized protein conserved in bacteria Function unknown 127512545 Common - hypothetical protein Shew_1616 2 None None None 127512890 Common - D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase Shew_1962 110 COG2027 DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) Cell envelope biogenesis, outer membrane 127512422 Common - hypothetical protein Shew_1493 1 None None None 127512832 Common - hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha subunit Shew_1904 148 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 127512027 Common - peptidase M28 Shew_1094 44 COG2234 Iap, Predicted aminopeptidases General function prediction only 127511497 Common - N-acetylmuramoyl-L-alanine amidase Shew_0563 169 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 127512749 Common - 2-methylcitrate synthase/citrate synthase II Shew_1821 194 COG0372 GltA, Citrate synthase Energy production and conversion 127514376 Common lpxC UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase Shew_3448 139 COG0774 LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase Cell envelope biogenesis, outer membrane 127514182 Common - cytochrome c family protein Shew_3254 20 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 127511557 Common - phage shock protein A, PspA Shew_0623 25 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 127514250 Common - RarD protein, DMT superfamily transporter Shew_3322 104 COG2962 RarD, Predicted permeases General function prediction only 127512841 Common - hypothetical protein Shew_1913 30 COG1896 COG1896, Predicted hydrolases of HD superfamily General function prediction only 127513651 Common - NUDIX hydrolase Shew_2723 16 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 127514122 Common - transcriptional regulator, LuxR family Shew_3194 145 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 127512843 Common - elongation factor P Shew_1915 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 127511432 Common - conserved hypothetical flavoprotein oxygenase Shew_0498 84 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 127513522 Nonpathogen - hypothetical protein Shew_2594 1 None None None 127514749 Common - hypothetical protein Shew_3821 10 None None None 127511859 Common - hypothetical protein Shew_0926 3 None None None 127514329 Common - periplasmic copper-binding Shew_3401 51 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 127511290 Common - ABC transporter-related protein Shew_0356 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 127511523 Common - alpha/beta hydrolase fold Shew_0589 71 COG0429 COG0429, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 127514509 Common - peptidase M16 domain protein Shew_3581 201 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 127513220 Common - transcriptional regulator, LysR family Shew_2292 174 COG0583 LysR, Transcriptional regulator Transcription 127512574 Common - sigma54 specific transcriptional regulator, Fis family Shew_1645 172 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 127513310 Common - cysteine synthase A Shew_2382 219 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 127511977 Common nhaR transcriptional activator NhaR Shew_1044 111 COG0583 LysR, Transcriptional regulator Transcription 127513225 Nonpathogen - PEGA domain protein Shew_2297 1 None None None 127512716 Common - CreA family protein Shew_1788 57 COG3045 CreA, Uncharacterized protein conserved in bacteria Function unknown 127512163 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Shew_1231 160 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 127514156 Common - hypothetical protein Shew_3228 9 None None None 127513957 Common - protein of unknown function DUF985 Shew_3029 57 COG3542 COG3542, Uncharacterized conserved protein Function unknown 127514346 Common - hypothetical protein Shew_3418 5 None None None 127511385 Common - hypothetical protein Shew_0451 23 COG3076 COG3076, Uncharacterized protein conserved in bacteria Function unknown 127512329 Common - NusG antitermination factor Shew_1398 43 COG0250 NusG, Transcription antiterminator Transcription 127513768 Common - Dihydrodipicolinate reductase Shew_2840 217 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 127514568 Nonpathogen - hypothetical protein Shew_3640 1 None None None 127511653 Common - periplasmic binding protein Shew_0719 161 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 127512659 Nonpathogen - hypothetical protein Shew_1730 1 None None None 127512789 Common - peptidase M15B and M15C, D,D-carboxypeptidase VanY/endolysin Shew_1861 29 COG1876 VanY, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 127512980 Common - transcriptional regulator, TetR family Shew_2052 87 COG1309 AcrR, Transcriptional regulator Transcription 127513613 Common - putative lipoprotein Shew_2685 13 None None None 127511867 Common - TPR repeat-containing protein Shew_0934 17 None None None 127511155 Common - tryptophanyl-tRNA synthetase Shew_0221 235 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 127514096 Common - hypothetical protein Shew_3168 88 COG2968 COG2968, Uncharacterized conserved protein Function unknown 127512740 Common - putative RNA methylase Shew_1812 166 COG0116 COG0116, Predicted N6-adenine-specific DNA methylase DNA replication, recombination, and repair 127514562 Common - RNA binding S1 domain protein Shew_3634 170 COG2183 Tex, Transcriptional accessory protein Transcription 127511731 Common - hypothetical protein Shew_0797 9 COG3463 COG3463, Predicted membrane protein Function unknown 127512382 Common - methylated-DNA--protein-cysteine methyltransferase Shew_1453 110 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 127511413 Common - HipA domain protein Shew_0479 49 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 127511660 Common - two component, sigma54 specific, transcriptional regulator, Fis family Shew_0726 197 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 127512293 Common - sigma54 specific transcriptional regulator, Fis family Shew_1362 170 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 127511231 Nonpathogen - hypothetical protein Shew_0297 1 None None None 127511847 Common - NADPH-dependent FMN reductase Shew_0914 23 COG0431 COG0431, Predicted flavoprotein General function prediction only 127513754 Common rbfA ribosome-binding factor A Shew_2826 109 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 127514026 Common - NADH:flavin oxidoreductase/NADH oxidase Shew_3098 177 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 127514611 Common - extracellular solute-binding protein, family 1 Shew_3683 62 COG2998 TupB, ABC-type tungstate transport system, permease component Coenzyme metabolism 127511638 Nonpathogen - hypothetical protein Shew_0704 1 None None None 127512661 Common - uncharacterized domain 1 protein Shew_1732 36 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 127514129 Common - ABC transporter-related protein Shew_3201 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 127512240 Nonpathogen - hypothetical protein Shew_1308 1 None None None 127512003 Common - Oxidoreductase FAD-binding domain protein Shew_1070 155 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 127512457 Common - OmpA domain protein Shew_1528 144 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 127513542 Common - two component transcriptional regulator, LuxR family Shew_2614 173 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 127513346 Common - hypothetical protein Shew_2418 78 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 127513491 Common - Alcohol dehydrogenase, zinc-binding domain protein Shew_2563 144 COG2130 COG2130, Putative NADP-dependent oxidoreductases General function prediction only 127511542 Common - molybdopterin oxidoreductase Shew_0608 183 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 127512322 Common - CheW protein Shew_1391 137 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 127512241 Common - methyl-accepting chemotaxis sensory transducer Shew_1310 139 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127514167 Common - Na-Ca exchanger/integrin-beta4 Shew_3239 24 None None None 127513529 Nonpathogen - hypothetical protein Shew_2601 1 None None None 127514758 Common - Integrase, catalytic region Shew_3830 144 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 127514196 Nonpathogen - hypothetical protein Shew_3268 6 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 127513785 Common - transcriptional regulator, LysR family Shew_2857 155 COG0583 LysR, Transcriptional regulator Transcription 127514315 Common - band 7 protein Shew_3387 218 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 127514548 Common - general secretion pathway protein C Shew_3620 30 COG3031 PulC, Type II secretory pathway, component PulC Intracellular trafficking and secretion 127514295 Common - hypothetical protein Shew_3367 24 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 127512884 Common - protein of unknown function DUF1049 Shew_1956 2 COG3771 COG3771, Predicted membrane protein Function unknown 127512247 Common - hypothetical protein Shew_1316 6 None None None 127514217 Common - ribonuclease R Shew_3289 203 COG0557 VacB, Exoribonuclease R Transcription 127514586 Common - hypothetical protein Shew_3658 2 None None None 127511993 Common - protein of unknown function DUF21 Shew_1060 217 COG4536 CorB, Putative Mg2+ and Co2+ transporter CorB Inorganic ion transport and metabolism 127512285 Common - flagellar hook-associated protein FlgK Shew_1354 123 COG1256 FlgK, Flagellar hook-associated protein Cell motility and secretion 127514160 Common - peptidase M50 Shew_3232 18 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 127512186 Common - phage integrase family protein Shew_1254 32 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 127512142 Common - stationary-phase survival protein SurE Shew_1210 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 127514655 Common - shikimate 5-dehydrogenase Shew_3727 223 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 127511803 Common rplU 50S ribosomal protein L21 Shew_0869 215 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 127513014 Common - hypothetical protein Shew_2086 1 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 127512107 Common - SEC-C motif domain protein Shew_1175 19 COG3555 COG3555, Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases Posttranslational modification, protein turnover, chaperones 127513719 Common - PAS/PAC sensor signal transduction histidine kinase Shew_2791 217 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 127514264 Common - transcriptional regulator, MarR family Shew_3336 109 COG1846 MarR, Transcriptional regulators Transcription 127511549 Common - bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase Shew_0615 220 COG4230 COG4230, Delta 1-pyrroline-5-carboxylate dehydrogenase Energy production and conversion 127511488 Common - glycerophosphoryl diester phosphodiesterase Shew_0554 146 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 127513682 Common - diguanylate cyclase Shew_2754 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127514683 Common - thioesterase superfamily protein Shew_3755 21 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 127513694 Common - thiamine biosynthesis protein ThiI Shew_2766 94 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 127513364 Common - membrane protein involved in aromatic hydrocarbon degradation Shew_2436 68 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 127513998 Common - extracellular solute-binding protein, family 3 Shew_3070 26 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 127513409 Common - porin, Gram-negative type Shew_2481 24 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 127513624 Common - integral membrane sensor signal transduction histidine kinase Shew_2696 214 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127511015 Common - two component transcriptional regulator, winged helix family Shew_0081 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127513057 Common - exodeoxyribonuclease V, gamma subunit Shew_2129 66 COG1330 RecC, Exonuclease V gamma subunit DNA replication, recombination, and repair 127512401 Common - nucleoid-associated protein NdpA Shew_1472 31 COG3081 COG3081, Nucleoid-associated protein General function prediction only 127513032 Common - major facilitator superfamily MFS_1 Shew_2104 120 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 127512444 Common - Na+/H+ antiporter NhaC Shew_1515 46 COG2056 COG2056, Predicted permease General function prediction only 127512530 Common - 3-oxoacyl-(acyl carrier protein) synthase III Shew_1601 220 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 127512773 Common - Lysine exporter protein (LYSE/YGGA) Shew_1845 82 COG1279 COG1279, Lysine efflux permease General function prediction only 127511010 Nonpathogen - Antibiotic biosynthesis monooxygenase Shew_0076 4 COG1359 COG1359, Uncharacterized conserved protein Function unknown 127512395 Common - hypothetical protein Shew_1466 19 COG2267 PldB, Lysophospholipase Lipid metabolism 127512132 Common - hybrid sensory histidine kinase BarA Shew_1200 226 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127512539 Common - cytidine deaminase Shew_1610 32 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 127512380 Common - ABC transporter-related protein Shew_1451 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 127512188 Common - hypothetical protein Shew_1256 1 None None None 127511777 Common - nitrate/nitrite sensor protein NarQ Shew_0843 146 COG3850 NarQ, Signal transduction histidine kinase, nitrate/nitrite-specific Signal transduction mechanisms 127512706 Common - glutamine amidotransferase Shew_1778 46 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 127513985 Nonpathogen - hypothetical protein Shew_3057 1 None None None 127511442 Common - Xanthine/uracil/vitamin C permease Shew_0508 18 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 127514113 Common - hypothetical protein Shew_3185 43 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 127514502 Common - Aldehyde dehydrogenase (NAD(+)) Shew_3574 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 127511021 Common moaA molybdenum cofactor biosynthesis protein A Shew_0087 203 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 127511463 Common - Sel1 domain protein repeat-containing protein Shew_0529 63 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 127511897 Common - protein of unknown function DUF861, cupin_3 Shew_0964 30 COG3450 COG3450, Predicted enzyme of the cupin superfamily General function prediction only 127514055 Common - aminopeptidase B Shew_3127 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 127510955 Common - Xaa-Pro dipeptidase Shew_0020 169 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 127511972 Common - PTSINtr with GAF domain, PtsP Shew_1039 235 COG3605 PtsP, Signal transduction protein containing GAF and PtsI domains Signal transduction mechanisms 127513188 Common - intracellular septation protein A Shew_2260 91 COG2917 COG2917, Intracellular septation protein A Cell division and chromosome partitioning 127514233 Common - Na+/Ca+ antiporter, CaCA family Shew_3305 117 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 127511451 Common - putative plasmid transfer protein Shew_0517 9 None None None 127511907 Common - spermidine/putrescine ABC transporter ATPase subunit Shew_0974 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 127512729 Common - putative solute/DNA competence effector Shew_1801 35 COG3109 ProQ, Activator of osmoprotectant transporter ProP Signal transduction mechanisms 127512803 Common - peptidase M28 Shew_1875 24 COG2234 Iap, Predicted aminopeptidases General function prediction only 127512478 Common - phosphoenolpyruvate synthase Shew_1549 234 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 127513467 Common - branched-chain amino acid transport Shew_2539 16 COG4392 COG4392, Predicted membrane protein Function unknown 127511833 Common - acyl-CoA dehydrogenase domain protein Shew_0900 157 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 127513496 Common - AMP-dependent synthetase and ligase Shew_2568 216 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 127512199 Common - phage integrase family protein Shew_1267 110 COG0582 XerC, Integrase DNA replication, recombination, and repair 127514064 Common - FAD linked oxidase domain protein Shew_3136 198 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 127514382 Common - cell division protein FtsW Shew_3454 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 127513341 Common - hypothetical protein Shew_2413 16 None None None 127512056 Common - A/G-specific adenine glycosylase Shew_1123 233 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 127513020 Common - thiazole biosynthesis family protein Shew_2092 168 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 127513100 Common - surface antigen (D15) Shew_2172 117 COG0729 COG0729, Outer membrane protein Cell envelope biogenesis, outer membrane 127513337 Common - short chain dehydrogenase Shew_2409 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 127513564 Common - methionine aminopeptidase Shew_2636 248 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 127514447 Common - outer membrane lipoprotein carrier protein LolA Shew_3519 22 None None None 127512192 Common - DNA methylase N-4/N-6 domain protein Shew_1260 71 COG2189 COG2189, Adenine specific DNA methylase Mod DNA replication, recombination, and repair 127511307 Common - protein of unknown function DUF971 Shew_0373 50 COG3536 COG3536, Uncharacterized protein conserved in bacteria Function unknown 127512449 Common - ribonuclease T Shew_1520 73 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 127511131 Common - protein of unknown function DUF796 Shew_0197 29 COG3157 Hcp, Hemolysin-coregulated protein (uncharacterized) Function unknown 127511048 Common - response regulator receiver protein Shew_0114 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127511308 Common hslU ATP-dependent protease ATP-binding subunit Shew_0374 209 COG1220 HslU, ATP-dependent protease HslVU (ClpYQ), ATPase subunit Posttranslational modification, protein turnover, chaperones 127510999 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Shew_0064 168 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 127512814 Common - alpha amylase, catalytic region Shew_1886 73 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 127513606 Common - electron transfer flavoprotein, alpha subunit Shew_2678 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 127513558 Common - phosphatidate cytidylyltransferase Shew_2630 215 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 127512626 Common - amino acid-binding ACT domain protein Shew_1697 24 COG2716 GcvR, Glycine cleavage system regulatory protein Amino acid transport and metabolism 127514558 Common - bioH protein Shew_3630 137 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 127514303 Common - 2-polyprenylphenol 6-hydroxylase Shew_3375 184 COG0661 AarF, Predicted unusual protein kinase General function prediction only 127513072 Common - response regulator receiver modulated CheW protein Shew_2144 155 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 127514740 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Shew_3812 80 COG0348 NapH, Polyferredoxin Energy production and conversion 127513402 Common - TonB family protein Shew_2474 35 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 127514495 Common - transcriptional regulator, TetR family Shew_3567 48 COG1309 AcrR, Transcriptional regulator Transcription 127514508 Common - peptidase M16 domain protein Shew_3580 176 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 127513200 Nonpathogen - hypothetical protein Shew_2272 1 None None None 127512904 Common - putative ATP-dependent protease La-relatedprotein Shew_1976 149 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 127513205 Common - DoxX family protein Shew_2277 25 COG2259 COG2259, Predicted membrane protein Function unknown 127513375 Common - hypothetical protein Shew_2447 13 None None None 127512641 Common - hypothetical protein Shew_1712 12 None None None 127512035 Common - hydroxymethylbutenyl pyrophosphate reductase Shew_1102 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 127512002 Common - hydroxylamine reductase Shew_1069 74 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 127511666 Common - diguanylate cyclase with PAS/PAC sensor Shew_0732 191 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127512465 Common - putative chloramphenicol acetyltransferase Shew_1536 166 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 127514021 Common - protein of unknown function DUF924 Shew_3093 63 COG3803 COG3803, Uncharacterized protein conserved in bacteria Function unknown 127513266 Common - S-adenosylmethionine--tRNA-ribosyltransferase-isomerase Shew_2338 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 127513599 Common - Alpha/beta hydrolase fold-3 domain protein Shew_2671 135 COG0657 Aes, Esterase/lipase Lipid metabolism 127513397 Common - GCN5-related N-acetyltransferase Shew_2469 122 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 127512854 Common - Transketolase, central region Shew_1926 209 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 127511114 Common rpsM 30S ribosomal protein S13 Shew_0180 236 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 127513843 Common - 4-diphosphocytidyl-2C-methyl-D-erythritol kinase Shew_2915 192 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 127513991 Common - glycine cleavage system protein H Shew_3063 186 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 127511087 Common rpsL 30S ribosomal protein S12 Shew_0153 238 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 127511458 Common - cytochrome c, class I Shew_0524 36 COG3258 COG3258, Cytochrome c Energy production and conversion 127512015 Nonpathogen - hypothetical protein Shew_1082 1 None None None 127514646 Common - hypothetical protein Shew_3718 22 COG3078 COG3078, Uncharacterized protein conserved in bacteria Function unknown 127512500 Nonpathogen - hypothetical protein Shew_1571 3 None None None 127512139 Common - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Shew_1207 195 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 127513839 Common - modification methylase, HemK family Shew_2911 225 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 127513660 Nonpathogen - hypothetical protein Shew_2732 2 None None None 127514135 Common napG quinol dehydrogenase periplasmic component Shew_3207 57 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 127511035 Common - Endoribonuclease L-PSP Shew_0101 26 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 127512801 Common - glucan 1,4-alpha-glucosidase Shew_1873 27 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 127513964 Common - hypothetical protein Shew_3036 73 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 127511535 Common - hypothetical protein Shew_0601 5 None None None 127514419 Common - hypothetical protein Shew_3491 13 COG3410 COG3410, Uncharacterized conserved protein Function unknown 127510970 Common - lipoprotein, putative Shew_0035 31 None None None 127513867 Common - Serine-type D-Ala-D-Ala carboxypeptidase Shew_2939 155 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 127514604 Common - TonB-dependent receptor, plug Shew_3676 116 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 127513948 Common - hypothetical protein Shew_3020 8 None None None 127511914 Common - response regulator receiver protein Shew_0981 222 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 127514033 Common - transcriptional regulator, LysR family Shew_3105 180 COG0583 LysR, Transcriptional regulator Transcription 127511118 Common rplQ 50S ribosomal protein L17 Shew_0184 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 127512967 Common - GCN5-related N-acetyltransferase Shew_2039 146 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 127512954 Common - alanine dehydrogenase Shew_2026 167 COG0686 Ald, Alanine dehydrogenase Amino acid transport and metabolism 127514038 Nonpathogen - hypothetical protein Shew_3110 1 None None None 127514493 Common - acriflavin resistance protein Shew_3565 183 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 127514384 Common - phospho-N-acetylmuramoyl-pentapeptide-transferase Shew_3456 225 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 127514699 Common - 2,3-diketo-5-methylthio-1-phosphopentane phosphatase Shew_3771 31 COG4229 COG4229, Predicted enolase-phosphatase Energy production and conversion 127513821 Common - nucleotide-binding protein Shew_2893 107 COG1666 COG1666, Uncharacterized protein conserved in bacteria Function unknown 127513781 Nonpathogen - hypothetical protein Shew_2853 1 None None None 127513973 Common - sugar-binding protein, putative Shew_3045 38 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 127512755 Common - methylation site containing protein Shew_1827 3 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 127512923 Common - PP-loop domain protein Shew_1995 161 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 127511388 Common - enoyl-CoA hydratase Shew_0454 158 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 127512705 Common - drug resistance transporter, Bcr/CflA subfamily Shew_1777 188 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 127511272 Common - thioredoxin Shew_0338 233 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 127511925 Common - BsuBIPstI restriction endonuclease domain protein Shew_0992 16 None None None 127511705 Common - thiol:disulfide interchange protein DsbC Shew_0771 68 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 127513175 Common - putative transcriptional regulator Shew_2247 152 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 127513830 Common - methyl-accepting chemotaxis sensory transducer Shew_2902 151 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127512996 Common - electron transport complex protein RnfC Shew_2068 86 COG4656 RnfC, Predicted NADH:ubiquinone oxidoreductase, subunit RnfC Energy production and conversion 127514417 Common - hypothetical protein Shew_3489 137 COG1561 COG1561, Uncharacterized stress-induced protein Function unknown 127514319 Common - protein of unknown function DUF465 Shew_3391 27 COG2841 COG2841, Uncharacterized protein conserved in bacteria Function unknown 127513792 Common - 3-hydroxyacyl-CoA dehydrogenase, NAD-binding Shew_2864 161 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 127511528 Common - hypothetical protein Shew_0594 23 COG3529 COG3529, Predicted nucleic-acid-binding protein containing a Zn-ribbon domain General function prediction only 127513811 Common - BolA family protein Shew_2883 96 COG0271 BolA, Stress-induced morphogen (activity unknown) Signal transduction mechanisms 127513562 Common tsf elongation factor Ts Shew_2634 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 127511521 Common - Phosphoribulokinase Shew_0587 51 COG3954 PrkB, Phosphoribulokinase Energy production and conversion 127511165 Common - protein of unknown function DUF1212 Shew_0231 20 COG2966 COG2966, Uncharacterized conserved protein Function unknown 127511399 Nonpathogen - hypothetical protein Shew_0465 4 None None None 127513513 Common - histone family protein nucleoid-structuring protein H-NS Shew_2585 29 COG2916 Hns, DNA-binding protein H-NS General function prediction only 127512047 Common - SapC family protein Shew_1114 26 None None None 127512893 Common pssA phosphatidylserine synthase Shew_1965 29 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 127514236 Common - protein of unknown function DUF1239 Shew_3308 34 COG3117 COG3117, Uncharacterized protein conserved in bacteria Function unknown 127512486 Common - Cupin 4 family protein Shew_1557 61 COG2850 COG2850, Uncharacterized conserved protein Function unknown 127512561 Common - lipoprotein releasing system, transmembrane protein, LolC/E family Shew_1632 160 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 127512986 Common - hypothetical protein Shew_2058 1 COG3691 COG3691, Uncharacterized protein conserved in bacteria Function unknown 127513916 Common - putative signal transduction protein Shew_2988 1 COG3434 COG3434, Predicted signal transduction protein containing EAL and modified HD-GYP domains Signal transduction mechanisms 127514521 Common - hypothetical protein Shew_3593 2 COG1368 MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily Cell envelope biogenesis, outer membrane 127512078 Common - translation initiation factor Sui1 Shew_1145 47 COG0023 SUI1, Translation initiation factor 1 (eIF-1/SUI1) and related proteins Translation, ribosomal structure and biogenesis 127514778 Common - parB-like partition protein Shew_3853 185 COG1475 Spo0J, Predicted transcriptional regulators Transcription 127513555 Common - surface antigen (D15) Shew_2627 161 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 127513872 Common - hypothetical protein Shew_2944 1 None None None 127514454 Common - 3-oxoacyl-(acyl carrier protein) synthase II Shew_3526 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127514403 Common - hypothetical protein Shew_3475 47 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 127514045 Common - hypothetical protein Shew_3117 10 None None None 127511744 Common - ion transport 2 domain protein Shew_0810 29 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 127511294 Common - UbiD family decarboxylase Shew_0360 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 127513430 Common - ABC transporter-related protein Shew_2502 249 COG4167 SapF, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 127512778 Common - diguanylate cyclase/phosphodiesterase with GAF sensor Shew_1850 181 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 127514668 Common - potassium uptake protein, TrkH family Shew_3740 137 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 127511951 Common - hypothetical protein Shew_1018 1 None None None 127511880 Common - Carboxypeptidase Taq Shew_0947 82 COG2317 COG2317, Zn-dependent carboxypeptidase Amino acid transport and metabolism 127512271 Common - FlgN family protein Shew_1340 7 COG3418 COG3418, Flagellar biosynthesis/type III secretory pathway chaperone Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 127514337 Common - putative lipoprotein Shew_3409 9 None None None 127512614 Common - Microbial collagenase Shew_1685 15 None None None 127511725 Common - Spermine synthase Shew_0791 22 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 127511235 Common - transcriptional regulator, AsnC family Shew_0301 151 COG1522 Lrp, Transcriptional regulators Transcription 127512042 Common - type IV pilus biogenesis protein, putative Shew_1109 33 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 127512792 Common - glucose-specific PTS system component Shew_1864 61 COG2190 NagE, Phosphotransferase system IIA components Carbohydrate transport and metabolism 127511089 Common - elongation factor G Shew_0155 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 127511107 Common rplF 50S ribosomal protein L6 Shew_0173 235 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 127512823 Common - Redoxin domain protein Shew_1895 164 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 127513131 Common - imidazole glycerol phosphate synthase subunit HisF Shew_2203 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 127513030 Common - hypothetical protein Shew_2102 27 COG4544 COG4544, Uncharacterized conserved protein Function unknown 127513744 Common - nucleoside-specific channel-forming protein, Tsx Shew_2816 21 COG3248 Tsx, Nucleoside-binding outer membrane protein Cell envelope biogenesis, outer membrane 127511572 Common - cell surface receptor IPT/TIG domain protein Shew_0638 14 None None None 127514551 Common - phosphoenolpyruvate carboxykinase Shew_3623 97 COG1866 PckA, Phosphoenolpyruvate carboxykinase (ATP) Energy production and conversion 127511995 Common - signal recognition particle protein Shew_1062 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 127511602 Common - hypothetical protein Shew_0668 6 None None None 127512239 Nonpathogen - hypothetical protein Shew_1307 2 None None None 127513389 Common - MORN variant repeat protein Shew_2461 32 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 127514100 Common - 4-aminobutyrate aminotransferase Shew_3172 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 127511371 Common - hypothetical protein Shew_0437 5 None None None 127511765 Common - CBS domain containing membrane protein Shew_0831 88 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 127513666 Common - alkylhydroperoxidase like protein, AhpD family Shew_2738 74 COG2128 COG2128, Uncharacterized conserved protein Function unknown 127512312 Common flhF flagellar biosynthesis regulator FlhF Shew_1381 247 COG1419 FlhF, Flagellar GTP-binding protein Cell motility and secretion 127512205 Common - hypothetical protein Shew_1273 1 None None None 127513548 Common dnaE DNA polymerase III subunit alpha Shew_2620 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 127511518 Common - hypothetical protein Shew_0584 1 COG3212 COG3212, Predicted membrane protein Function unknown 127512280 Common flgF flagellar basal body rod protein FlgF Shew_1349 123 COG4787 FlgF, Flagellar basal body rod protein Cell motility and secretion 127514207 Common - hypothetical protein Shew_3279 21 COG3591 COG3591, V8-like Glu-specific endopeptidase Amino acid transport and metabolism 127511082 Common - ribosomal protein L1 Shew_0148 247 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 127513689 Common - hypothetical protein Shew_2761 46 COG2933 COG2933, Predicted SAM-dependent methyltransferase General function prediction only 127513048 Common - hypothetical protein Shew_2120 43 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 127512157 Common - hypothetical protein Shew_1225 82 COG1238 COG1238, Predicted membrane protein Function unknown 127512782 Common - hypothetical protein Shew_1854 4 None None None 127514663 Common - Peptidoglycan-binding LysM Shew_3735 48 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 127514679 Common - Lysine exporter protein (LYSE/YGGA) Shew_3751 99 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 127513822 Common - VanZ family protein Shew_2894 8 COG5652 COG5652, Predicted integral membrane protein Function unknown 127510936 Common dnaA chromosomal replication initiation protein Shew_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 127513528 Common - hypothetical protein Shew_2600 1 None None None 127511752 Common - peptidase U32 Shew_0818 140 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 127512684 Common - hydrogenase expression/formation protein HypE Shew_1756 143 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 127514161 Common - transcriptional regulator, Crp/Fnr family Shew_3233 110 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 127514641 Common - isoprenoid biosynthesis protein with amidotransferase-like domain Shew_3713 38 COG3155 ElbB, Uncharacterized protein involved in an early stage of isoprenoid biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 127514721 Common - hypothetical protein Shew_3793 12 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 127512130 Common - hypothetical protein Shew_1198 1 None None None 127512393 Common nadE NAD synthetase Shew_1464 172 COG0171 NadE, NAD synthase Coenzyme metabolism 127513038 Common - hypothetical protein Shew_2110 11 None None None 127511146 Common - type IV pilus secretin PilQ Shew_0212 141 COG4796 HofQ, Type II secretory pathway, component HofQ Intracellular trafficking and secretion 127510940 Nonpathogen - hypothetical protein Shew_0005 1 None None None 127511650 Common - cobalbumin biosynthesis enzyme Shew_0716 129 COG2087 CobU, Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase Coenzyme metabolism 127512413 Common - Cyclopropane-fatty-acyl-phospholipid synthase Shew_1484 127 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 127511008 Common - coproporphyrinogen III oxidase Shew_0073 203 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 127514527 Common - 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase Shew_3599 78 COG1165 MenD, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Coenzyme metabolism 127512771 Common - protein of unknown function UPF0118 Shew_1843 184 COG0628 PerM, Predicted permease General function prediction only 127512296 Common - flagellar hook-basal body complex subunit FliE Shew_1365 81 COG1677 FliE, Flagellar hook-basal body protein Cell motility and secretion / Intracellular trafficking and secretion 127512373 Common - TRAP dicarboxylate transporter, DctM subunit Shew_1444 135 COG1593 DctQ, TRAP-type C4-dicarboxylate transport system, large permease component Carbohydrate transport and metabolism 127511530 Common - methyl-accepting chemotaxis sensory transducer Shew_0596 141 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127512935 Common - hypothetical protein Shew_2007 2 None None None 127514105 Common - hypothetical protein Shew_3177 6 None None None 127510951 Common - ybaK/ebsC protein Shew_0016 108 COG2606 EbsC, Uncharacterized conserved protein Function unknown 127512260 Common - N-acylneuraminate-9-phosphate synthase Shew_1329 78 COG2089 SpsE, Sialic acid synthase Cell envelope biogenesis, outer membrane 127512194 Nonpathogen - hypothetical protein Shew_1262 1 None None None 127512552 Common - hypothetical protein Shew_1623 7 None None None 127511815 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Shew_0881 156 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 127513099 Common - peptidase T2, asparaginase 2 Shew_2171 84 COG1446 COG1446, Asparaginase Amino acid transport and metabolism 127511344 Common - peptidase U62, modulator of DNA gyrase Shew_0410 170 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 127514223 Common - AFG1-family ATPase Shew_3295 104 COG1485 COG1485, Predicted ATPase General function prediction only 127513494 Common - hypothetical protein Shew_2566 2 None None None 127512203 Common - SmpA/OmlA domain protein Shew_1271 61 COG2913 SmpA, Small protein A (tmRNA-binding) Translation, ribosomal structure and biogenesis 127512472 Common - secretion protein HlyD family protein Shew_1543 122 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 127512265 Common - 3-oxoacyl-(acyl-carrier-protein) synthase Shew_1334 211 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 127514542 Common - general secretion pathway protein I Shew_3614 41 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 127511990 Common - pyridoxal phosphate biosynthetic protein PdxJ Shew_1057 139 COG0854 PdxJ, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 127514356 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Shew_3428 190 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 127513429 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Shew_2501 249 COG4170 SapD, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 127511584 Common - hypothetical protein Shew_0650 6 None None None 127513063 Common ushA bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor Shew_2135 126 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 127514006 Common - Ppx/GppA phosphatase Shew_3078 180 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 127513486 Common - 1,4-dihydroxy-2-naphthoate octaprenyltransferase Shew_2558 101 COG1575 MenA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase Coenzyme metabolism 127513779 Common - peptidase M17, leucyl aminopeptidase domain protein Shew_2851 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 127512812 Common - DEAD/DEAH box helicase domain protein Shew_1884 239 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 127512356 Common - 3'(2'),5'-bisphosphate nucleotidase Shew_1427 186 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 127511353 Common - glyceraldehyde-3-phosphate dehydrogenase Shew_0419 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 127512128 Common - recombination and repair protein Shew_1196 198 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 127514001 Common - uracil-DNA glycosylase Shew_3073 129 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 127511263 Common - transcriptional regulator, Fis family Shew_0329 97 COG2901 Fis, Factor for inversion stimulation Fis, transcriptional activator Transcription / DNA replication, recombination, and repair 127510982 Common - molybdopterin biosynthesis protein MoeB Shew_0047 223 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 127513390 Common - MORN variant repeat protein Shew_2462 16 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 127511337 Common - cell shape determining protein, MreB/Mrl family Shew_0403 233 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 127514533 Common - cell division ATP-binding protein FtsE Shew_3605 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 127514785 Common - Lysine exporter protein (LYSE/YGGA) Shew_3860 120 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 127514738 Common - transcriptional regulator, BadM/Rrf2 family Shew_3810 136 COG1959 COG1959, Predicted transcriptional regulator Transcription 127514751 Nonpathogen - transcriptional regulator, XRE family Shew_3823 2 None None None 127513451 Common - hypothetical protein Shew_2523 6 None None None 127514460 Common - globin Shew_3532 59 COG1017 Hmp, Hemoglobin-like flavoprotein Energy production and conversion 127514421 Common - acetyl-CoA hydrolase/transferase Shew_3493 102 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 127512509 Common - DNA polymerase III, delta prime subunit Shew_1580 181 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 127513519 Nonpathogen - hypothetical protein Shew_2591 1 None None None 127514257 Common - diguanylate cyclase/phosphodiesterase with GAF sensor Shew_3329 171 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 127512692 Common - nickel-dependent hydrogenase, large subunit Shew_1764 105 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 127511422 Common - transcriptional regulator, ArsR family Shew_0488 95 COG0640 ArsR, Predicted transcriptional regulators Transcription 127511962 Common - hypothetical protein Shew_1029 19 COG5483 COG5483, Uncharacterized conserved protein Function unknown 127511323 Common - pilus (MSHA type) biogenesis protein MshL Shew_0389 141 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 127512737 Common - NAD-glutamate dehydrogenase Shew_1809 77 COG2902 COG2902, NAD-specific glutamate dehydrogenase Amino acid transport and metabolism 127512255 Nonpathogen - hypothetical protein Shew_1324 1 None None None 127514618 Common - formamidopyrimidine-DNA glycosylase Shew_3690 181 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 127513579 Common - hypothetical protein Shew_2651 2 None None None 127511092 Common rplC 50S ribosomal protein L3 Shew_0158 235 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 127511106 Common rpsH 30S ribosomal protein S8 Shew_0172 235 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 127511253 Common cyaA adenylate cyclase Shew_0319 25 COG3072 CyaA, Adenylate cyclase Nucleotide transport and metabolism 127511751 Common - Cupin 2, conserved barrel domain protein Shew_0817 33 None None None 127512097 Common - cold-shock DNA-binding domain protein Shew_1165 183 COG1278 CspC, Cold shock proteins Transcription 127512990 Common - exsB protein Shew_2062 175 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 127512479 Common - FAD linked oxidase domain protein Shew_1550 201 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 127511734 Common - FAD dependent oxidoreductase Shew_0800 142 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 127513853 Common - hypothetical protein Shew_2925 203 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 127511051 Common - protoheme IX farnesyltransferase Shew_0117 174 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 127512022 Common - transaldolase B Shew_1089 177 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 127511378 Common - MscS Mechanosensitive ion channel Shew_0444 230 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 127511269 Common sdhB succinate dehydrogenase iron-sulfur subunit Shew_0335 207 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 127512090 Common - Alkaline phosphatase Shew_1158 85 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 127514768 Common - DsrE family protein Shew_3843 25 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 127512651 Common - dethiobiotin synthase Shew_1722 153 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 127511181 Common - hypothetical protein Shew_0247 7 None None None 127514175 Common - hypothetical protein Shew_3247 3 None None None 127513243 Common - iron-sulfur cluster assembly protein IscA Shew_2315 163 COG0316 IscA, Uncharacterized conserved protein Function unknown 127512082 Common - transcriptional regulator, LysR family Shew_1149 176 COG0583 LysR, Transcriptional regulator Transcription 127513446 Common - FeoA family protein Shew_2518 37 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 127512333 Common - glucose-1-phosphate thymidylyltransferase Shew_1402 233 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 127512521 Common - sulphate transporter Shew_1592 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 127512254 Common - acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II-like protein Shew_1323 16 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127513550 Common lpxB lipid-A-disaccharide synthase Shew_2622 139 COG0763 LpxB, Lipid A disaccharide synthetase Cell envelope biogenesis, outer membrane 127514456 Common - Rhodanese domain protein Shew_3528 86 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 127514325 Common - GCN5-related N-acetyltransferase Shew_3397 81 COG2153 ElaA, Predicted acyltransferase General function prediction only 127512168 Common - OsmC family protein Shew_1236 45 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 127512591 Common - NAD-dependent deacetylase Shew_1662 150 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 127514591 Nonpathogen - hypothetical protein Shew_3663 1 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 127513733 Common - Choloylglycine hydrolase Shew_2805 36 COG3049 COG3049, Penicillin V acylase and related amidases Cell envelope biogenesis, outer membrane 127513755 Common infB translation initiation factor IF-2 Shew_2827 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 127511587 Common - transcriptional regulator, LuxR family Shew_0653 107 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 127511401 Common - efflux transporter, RND family, MFP subunit Shew_0467 166 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 127513590 Common - Cupin 2, conserved barrel domain protein Shew_2662 10 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 127514761 Common - IS66 Orf2 family protein Shew_3836 50 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 127514468 Common - NapC/NirT cytochrome c domain protein Shew_3540 47 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 127514111 Nonpathogen - hypothetical protein Shew_3183 1 None None None 127511042 Common - polysaccharide deacetylase Shew_0108 94 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 127512517 Common - protein tyrosine phosphatase Shew_1588 131 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 127513456 Common - transcriptional regulator, CdaR Shew_2528 43 COG3835 CdaR, Sugar diacid utilization regulator Transcription / Signal transduction mechanisms 127511756 Common - Lysine exporter protein (LYSE/YGGA) Shew_0822 4 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 127514210 Common - ribosomal protein S18 Shew_3282 214 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 127511947 Common - transcriptional regulator, XRE family Shew_1014 13 COG1813 COG1813, Predicted transcription factor, homolog of eukaryotic MBF1 Transcription 127513571 Common - Pseudouridylate synthase Shew_2643 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 127512307 Common fliP flagellar biosynthesis protein FliP Shew_1376 128 COG1338 FliP, Flagellar biosynthesis pathway, component FliP Cell motility and secretion / Intracellular trafficking and secretion 127512319 Common - hypothetical protein Shew_1388 1 None None None 127511681 Common - GGDEF domain protein Shew_0747 9 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127512951 Common - outer membrane lipoprotein carrier protein LolA Shew_2023 66 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 127514194 Common dipZ thiol:disulfide interchange protein precursor Shew_3266 160 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 127513886 Common - hypothetical protein Shew_2958 20 COG3595 COG3595, Uncharacterized conserved protein Function unknown 127511066 Common - transcriptional regulator, TetR family Shew_0132 5 COG4187 RocB, Arginine degradation protein (predicted deacylase) Amino acid transport and metabolism 127511676 Common - hypothetical protein Shew_0742 1 None None None 127513581 Common - SecY interacting protein Syd Shew_2653 19 None None None 127512229 Common - inositol-5-monophosphate dehydrogenase Shew_1297 234 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 127512540 Common sbcB exonuclease I Shew_1611 51 COG2925 SbcB, Exonuclease I DNA replication, recombination, and repair 127511568 Nonpathogen - hypothetical protein Shew_0634 1 None None None 127513618 Common - TonB-dependent receptor, plug Shew_2690 119 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 127511719 Common - Methyltransferase type 12 Shew_0785 42 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 127511566 Common - OmpA/MotB domain protein Shew_0632 156 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 127511193 Common - hypothetical protein Shew_0259 22 None None None 127512175 Common - Peptidyl-Lys metalloendopeptidase Shew_1243 8 None None None 127511883 Common - DEAD/DEAH box helicase domain protein Shew_0950 236 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 127514317 Common - hypothetical protein Shew_3389 12 COG3248 Tsx, Nucleoside-binding outer membrane protein Cell envelope biogenesis, outer membrane 127512173 Common - sigma 54 modulation protein/ribosomal protein S30EA Shew_1241 59 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 127513335 Common - predicted inner membrane peptidase Shew_2407 189 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 127512636 Nonpathogen - hypothetical protein Shew_1707 1 None None None 127512494 Common - ATP-dependent Clp protease adaptor protein ClpS Shew_1565 119 COG2127 COG2127, Uncharacterized conserved protein Function unknown 127512235 Common - cytochrome d ubiquinol oxidase, subunit II Shew_1303 156 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 127511618 Nonpathogen - hypothetical protein Shew_0684 1 None None None 127512730 Common - carboxy-terminal protease Shew_1802 181 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 127513022 Common - UBA/THIF-type NAD/FAD binding protein Shew_2094 223 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 127512889 Common - acyl-CoA dehydrogenase domain protein Shew_1961 154 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 127510948 Common - amidohydrolase Shew_0013 156 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 127514625 Common - glycosyl transferase, family 9 Shew_3697 6 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 127511183 Common - GCN5-related N-acetyltransferase Shew_0249 35 COG3153 COG3153, Predicted acetyltransferase General function prediction only 127513275 Common - phosphonate ABC transporter, periplasmic phosphonate-binding protein Shew_2347 73 COG3221 PhnD, ABC-type phosphate/phosphonate transport system, periplasmic component Inorganic ion transport and metabolism 127513377 Common - anaerobic ribonucleoside triphosphate reductase Shew_2449 96 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 127511473 Nonpathogen - hypothetical protein Shew_0539 1 COG1480 COG1480, Predicted membrane-associated HD superfamily hydrolase General function prediction only 127512038 Common - type IV pilus assembly protein PilX Shew_1105 1 None None None 127513439 Common cysS cysteinyl-tRNA synthetase Shew_2511 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 127511099 Common rplP 50S ribosomal protein L16 Shew_0165 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 127512865 Common - peptidase M14, carboxypeptidase A Shew_1937 32 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 127513297 Common - cyclic nucleotide-binding protein Shew_2369 184 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 127514084 Common - hypothetical protein Shew_3156 19 None None None 127511595 Nonpathogen - hypothetical protein Shew_0661 2 None None None 127511766 Common - Alkaline phosphatase Shew_0832 57 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 127513897 Nonpathogen - hypothetical protein Shew_2969 1 None None None 127512147 Common recA recombinase A Shew_1215 220 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 127512747 Common - transcriptional regulator, GntR family Shew_1819 133 COG1802 GntR, Transcriptional regulators Transcription 127511393 Common - PAS/PAC sensor hybrid histidine kinase Shew_0459 225 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127514262 Nonpathogen - hypothetical protein Shew_3334 1 None None None 127513580 Common - hypothetical protein Shew_2652 13 COG5595 COG5595, Zn-ribbon-containing, possibly nucleic-acid-binding protein General function prediction only 127514243 Common - Phosphotransferase system, phosphocarrier protein HPr Shew_3315 22 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 127512223 Common - histidyl-tRNA synthetase Shew_1291 248 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 127511579 Common - type II and III secretion system protein Shew_0645 142 COG4964 CpaC, Flp pilus assembly protein, secretin CpaC Intracellular trafficking and secretion 127513403 Common - Biopolymer transport protein ExbD/TolR Shew_2475 130 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 127514154 Common - Alkaline phosphatase Shew_3226 85 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 127511826 Common - hypothetical protein Shew_0893 8 None None None 127513282 Common - hypothetical protein Shew_2354 1 None None None 127513423 Common pspB phage shock protein B Shew_2495 23 None None None 127513484 Common - acyl-CoA thioesterase II Shew_2556 77 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 127512089 Common - Alkaline phosphatase Shew_1157 86 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 127513926 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Shew_2998 10 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 127513355 Common - ATPase associated with various cellular activities, AAA_3 Shew_2427 180 COG0714 COG0714, MoxR-like ATPases General function prediction only 127514224 Common - protease Do Shew_3296 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 127511726 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Shew_0792 218 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 127514515 Common - hypothetical protein Shew_3587 2 None None None 162139867 Common - phosphoserine aminotransferase Shew_1950 112 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 127511383 Common - ABC-3 protein Shew_0449 9 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 127513766 Common carB carbamoyl phosphate synthase large subunit Shew_2838 236 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 127512982 Common - Smr protein/MutS2 Shew_2054 40 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 127514094 Common - extracellular solute-binding protein, family 3 Shew_3166 187 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 127513807 Common - Na(+)-translocating NADH-quinone reductase subunit C Shew_2879 45 COG2869 NqrC, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC Energy production and conversion 127514638 Common tdh L-threonine 3-dehydrogenase Shew_3710 209 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 127512593 Common - hypothetical protein Shew_1664 27 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 127511686 Common - transketolase Shew_0752 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 127511636 Common - Rhomboid family protein Shew_0702 136 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 127513692 Common - DNA-binding transcriptional activator GcvA Shew_2764 181 COG0583 LysR, Transcriptional regulator Transcription 127511167 Common - hypothetical protein Shew_0233 73 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 127514731 Common gpsA NAD(P)H-dependent glycerol-3-phosphate dehydrogenase Shew_3803 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 127512932 Common - hypothetical protein Shew_2004 7 None None None 127513460 Common - peptidase C26 Shew_2532 120 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 127512657 Common - curli production assembly/transport component CsgF precursor Shew_1728 12 None None None 127514657 Common - coproporphyrinogen III oxidase Shew_3729 113 COG0408 HemF, Coproporphyrinogen III oxidase Coenzyme metabolism 127512678 Nonpathogen - hypothetical protein Shew_1749 1 None None None 127513710 Common - putative signal transduction protein Shew_2782 43 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 127511220 Common - extracellular solute-binding protein, family 3 Shew_0286 4 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 127511001 Nonpathogen - hypothetical protein Shew_0066 1 None None None 127511454 Common - O-succinylhomoserine (thiol)-lyase Shew_0520 207 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 127513759 Common - Triose-phosphate isomerase Shew_2831 217 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 127513043 Common - Lytic transglycosylase, catalytic Shew_2115 130 COG1388 LytE, FOG: LysM repeat Cell envelope biogenesis, outer membrane 127514057 Common - transcriptional regulator, TraR/DksA family Shew_3129 148 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 127511589 Common - peptidase M16 domain protein Shew_0655 195 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 127511651 Common - cobyric acid synthase Shew_0717 158 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 127511032 Common - integral membrane sensor signal transduction histidine kinase Shew_0098 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127513012 Common - gonadoliberin III-related protein Shew_2084 18 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 127512012 Common thrA bifunctional aspartokinase I/homeserine dehydrogenase I Shew_1079 235 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 127514564 Common - transcription elongation factor GreB Shew_3636 196 COG0782 GreA, Transcription elongation factor Transcription 127513348 Common - peptidase M16 domain protein Shew_2420 181 COG1025 Ptr, Secreted/periplasmic Zn-dependent peptidases, insulinase-like Posttranslational modification, protein turnover, chaperones 127511157 Common - protein of unknown function DUF6, transmembrane Shew_0223 65 COG2962 RarD, Predicted permeases General function prediction only 127514766 Common - TonB-dependent siderophore receptor Shew_3841 114 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 127512140 Common - 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Shew_1208 189 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 127511412 Common - transcriptional regulator, XRE family Shew_0478 5 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 127514520 Common - Sel1 domain protein repeat-containing protein Shew_3592 62 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 127512310 Common flhB flagellar biosynthesis protein FlhB Shew_1379 130 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 127513358 Common - von Willebrand factor, type A Shew_2430 86 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 127511330 Common - methylation site containing protein Shew_0396 7 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 127512320 Common - Cobyrinic acid a,c-diamide synthase Shew_1389 229 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 127512184 Common - transposase Shew_1252 8 None None None 127513724 Common - periplasmic nitrate reductase NapE Shew_2796 3 COG4459 NapE, Periplasmic nitrate reductase system, NapE component Energy production and conversion 127511540 Common - Polysulphide reductase, NrfD Shew_0606 26 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 127513544 Common - lipolytic enzyme, G-D-S-L family Shew_2616 26 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 127512532 Common - 3-oxoacyl-(acyl-carrier-protein) reductase Shew_1603 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 127512243 Common - efflux transporter, RND family, MFP subunit Shew_1312 159 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 127514313 Common uvrD DNA-dependent helicase II Shew_3385 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 127514276 Common - pseudouridine synthase Shew_3348 214 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 127512327 Common - response regulator receiver protein Shew_1396 214 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 127513611 Common - hypothetical protein Shew_2683 7 None None None 127512851 Common - peptide methionine sulfoxide reductase Shew_1923 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 127511648 Common cobT nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Shew_0714 118 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 127514165 Common - Na-Ca exchanger/integrin-beta4 Shew_3237 23 None None None 127512302 Common - flagellar hook-length control protein Shew_1371 30 COG3144 FliK, Flagellar hook-length control protein Cell motility and secretion 127512287 Common - flagellin domain protein Shew_1356 121 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 127513103 Common nhaB sodium/proton antiporter Shew_2175 34 COG3067 NhaB, Na+/H+ antiporter Inorganic ion transport and metabolism 127513414 Common - hypothetical protein Shew_2486 15 COG3110 COG3110, Uncharacterized protein conserved in bacteria Function unknown 127512361 Common - ferredoxin-type protein NapF Shew_1432 72 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 127512105 Common - protein of unknown function DUF88 Shew_1173 58 COG1432 COG1432, Uncharacterized conserved protein Function unknown 127511547 Common - cysteine/glutathione ABC transporter membrane/ATP-binding component Shew_0613 249 COG4988 CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 127511614 Common - transcriptional regulator, LysR family Shew_0680 156 COG0583 LysR, Transcriptional regulator Transcription 127511919 Common - hypothetical protein Shew_0986 2 COG4519 COG4519, Uncharacterized protein conserved in bacteria Function unknown 127513407 Common - Methyltransferase type 11 Shew_2479 42 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 127510962 Common - Glutathione S-transferase, N-terminal domain Shew_0027 59 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 127511728 Common - diguanylate cyclase Shew_0794 177 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 127511844 Nonpathogen - hypothetical protein Shew_0911 1 None None None 127511782 Common - hypothetical protein Shew_0848 2 None None None 127514623 Common - cytidyltransferase-related domain protein Shew_3695 140 COG0615 TagD, Cytidylyltransferase Cell envelope biogenesis, outer membrane / Lipid metabolism 127513748 Common prfC peptide chain release factor 3 Shew_2820 249 COG4108 PrfC, Peptide chain release factor RF-3 Translation, ribosomal structure and biogenesis 127511319 Common - conserved hypothetical biogenesis protein MshI Shew_0385 13 None None None 127512346 Common - undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase Shew_1416 160 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 127514373 Common - preprotein translocase subunit SecA Shew_3445 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 127511912 Common - response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Shew_0979 215 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 127513178 Common - PHP C-terminal domain protein Shew_2250 131 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 127514530 Common - O-succinylbenzoate-CoA ligase Shew_3602 213 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127513503 Common - 3-oxoacid CoA-transferase, A subunit Shew_2575 106 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 127513186 Common - NADH:ubiquinone oxidoreductase complex I intermediate-associated protein 30 Shew_2258 23 None None None 127513055 Common - protein of unknown function DUF58 Shew_2127 36 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 127513232 Common - Sporulation domain protein Shew_2304 20 COG3147 DedD, Uncharacterized protein conserved in bacteria Function unknown 127513549 Common - Ribonuclease H Shew_2621 228 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 127513845 Nonpathogen - hypothetical protein Shew_2917 1 None None None 127511361 Common - hypothetical protein Shew_0427 80 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 127513309 Common - RDD domain containing protein Shew_2381 2 COG1714 COG1714, Predicted membrane protein/domain Function unknown 127513003 Common ruvB Holliday junction DNA helicase B Shew_2075 240 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 127513476 Common - potassium efflux system protein Shew_2548 180 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 127513630 Nonpathogen - hypothetical protein Shew_2702 1 None None None 127512177 Common - transcriptional regulator, LysR family Shew_1245 191 COG0583 LysR, Transcriptional regulator Transcription 127511555 Common - hypothetical protein Shew_0621 6 None None None 127511706 Common - single-stranded-DNA-specific exonuclease RecJ Shew_0772 193 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 127512845 Common - flavodoxin FldA Shew_1917 72 COG0716 FldA, Flavodoxins Energy production and conversion 127514428 Common - putative endoribonuclease L-PSP Shew_3500 188 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 127513125 Common hisG ATP phosphoribosyltransferase Shew_2197 212 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 127513790 Common - short chain dehydrogenase Shew_2862 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 127514794 Common rpmH 50S ribosomal protein L34 Shew_3869 197 None None None 127513512 Common - electron transfer flavoprotein beta-subunit Shew_2584 153 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 127512860 Common cls cardiolipin synthetase Shew_1932 148 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 127512892 Common - hypothetical protein Shew_1964 10 None None None 127511975 Common - Na+/H+ antiporter NhaA Shew_1042 106 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 127511966 Common - conserved hypothetical radical SAM protein Shew_1033 103 COG1242 COG1242, Predicted Fe-S oxidoreductase General function prediction only 127514287 Common - hypothetical protein Shew_3359 1 None None None 127513124 Common - helicase c2 Shew_2196 149 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 127514569 Common - Redoxin domain protein Shew_3641 82 COG0678 AHP1, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 127514600 Common - hypothetical protein Shew_3672 13 COG1571 COG1571, Predicted DNA-binding protein containing a Zn-ribbon domain General function prediction only 127512506 Common - aminotransferase, class IV Shew_1577 178 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 127513081 Common - transcriptional regulator, LysR family Shew_2153 172 COG0583 LysR, Transcriptional regulator Transcription 127514361 Common - regulatory protein AmpE Shew_3433 20 COG3725 AmpE, Membrane protein required for beta-lactamase induction Defense mechanisms 127512281 Common flgG flagellar basal body rod protein FlgG Shew_1350 126 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 127511870 Common - transcriptional regulator, CadC Shew_0937 10 COG3710 CadC, DNA-binding winged-HTH domains Transcription 127514692 Nonpathogen - hypothetical protein Shew_3764 5 None None None 127511786 Common - hypothetical protein Shew_0852 1 None None None 127513800 Common - bacterioferritin Shew_2872 101 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 127511525 Common - glucose-methanol-choline oxidoreductase Shew_0591 56 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 127510979 Common - acriflavin resistance protein Shew_0044 184 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 127512727 Common - YebG family protein Shew_1799 17 COG3141 COG3141, Uncharacterized protein conserved in bacteria Function unknown 127514252 Common - hypothetical protein Shew_3324 133 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 127514602 Nonpathogen - cobalt transport protein Shew_3674 2 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 127511215 Common - phospholipid/glycerol acyltransferase Shew_0281 34 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 127514389 Common mraW S-adenosyl-methyltransferase MraW Shew_3461 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 127512428 Common - putative nitrogen regulatory protein P-II Shew_1499 22 None None None 127511795 Common - extracellular solute-binding protein, family 1 Shew_0861 107 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 127511310 Common - Curlin associated repeat protein Shew_0376 51 None None None 127513955 Common - hypothetical protein Shew_3027 20 None None None 127512455 Common - TolA family protein Shew_1526 24 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 127513604 Common - L-carnitine/gamma-butyrobetaine antiporter Shew_2676 96 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 127514506 Common - hypothetical protein Shew_3578 1 None None None 127513248 Common - RNA methyltransferase, TrmH family, group 1 Shew_2320 166 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 127511537 Common - glutathione-dependent formaldehyde-activating, GFA Shew_0603 70 COG3791 COG3791, Uncharacterized conserved protein Function unknown 127513068 Common - hypothetical protein Shew_2140 36 COG2378 COG2378, Predicted transcriptional regulator Transcription 127511935 Common - dihydroneopterin aldolase Shew_1002 101 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 127512190 Common - phage transcriptional regulator, AlpA Shew_1258 40 COG3311 AlpA, Predicted transcriptional regulator Transcription 127512687 Common - hydrogenase accessory protein HypB Shew_1759 140 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 127513070 Common - hypothetical protein Shew_2142 10 None None None 127513422 Common - phage shock protein C, PspC Shew_2494 34 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 127513869 Common - lipoate-protein ligase B Shew_2941 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 127512701 Common - transcriptional regulator, LysR family Shew_1773 108 COG0583 LysR, Transcriptional regulator Transcription 127511697 Common - putative PAS/PAC sensor protein Shew_0763 5 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127510991 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Shew_0056 78 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 127511690 Common - protein of unknown function DUF481 Shew_0756 32 COG3137 COG3137, Putative salt-induced outer membrane protein Cell envelope biogenesis, outer membrane 127512114 Common - metallophosphoesterase Shew_1182 15 None None None 127512389 Common - pseudouridine synthase Shew_1460 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 127511229 Nonpathogen - hypothetical protein Shew_0295 1 None None None 127512859 Common - alkylphosphonate utilization operon protein PhnA Shew_1931 103 COG2824 PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism Inorganic ion transport and metabolism 127513373 Common - hypothetical protein Shew_2445 1 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 127514133 Common - NapD family protein Shew_3205 26 COG3062 NapD, Uncharacterized protein involved in formation of periplasmic nitrate reductase Inorganic ion transport and metabolism 127511478 Common tolC outer membrane channel protein Shew_0544 141 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 127513946 Common - alpha/beta hydrolase fold Shew_3018 69 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 127512938 Common - efflux transporter, RND family, MFP subunit Shew_2010 147 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 127513097 Common - hypothetical protein Shew_2169 29 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 127514616 Common - molybdenum cofactor biosynthesis protein A Shew_3688 203 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 127514031 Common - aldehyde dehydrogenase Shew_3103 219 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 127513206 Common - transcriptional regulator, LysR family Shew_2278 187 COG0583 LysR, Transcriptional regulator Transcription 127511085 Common - DNA-directed RNA polymerase, beta subunit Shew_0151 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 127511809 Common - hypothetical protein Shew_0875 4 None None None 127512137 Common - Phosphopyruvate hydratase Shew_1205 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 127514393 Common - hypothetical protein Shew_3465 1 None None None 127511037 Common - sodium/glutamate symporter Shew_0103 53 COG0786 GltS, Na+/glutamate symporter Amino acid transport and metabolism 127512009 Common - Trp operon repressor Shew_1076 20 COG2973 TrpR, Trp operon repressor Transcription 127514037 Common - protein of unknown function DUF6, transmembrane Shew_3109 26 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 127512013 Common - homoserine kinase Shew_1080 116 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 127512583 Common sdhB succinate dehydrogenase iron-sulfur subunit Shew_1654 198 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 127511781 Common - Rh family protein/ammonium transporter Shew_0847 203 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 127512604 Common - peptidase S9, prolyl oligopeptidase active site domain protein Shew_1675 111 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 127513281 Common - magnesium and cobalt transport protein CorA Shew_2353 152 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 127514143 Common - ATPase, P-type (transporting), HAD superfamily, subfamily IC Shew_3215 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 127513400 Common - diguanylate cyclase Shew_2472 6 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127514571 Common - hypothetical protein Shew_3643 5 None None None 127511012 Common - PfkB domain protein Shew_0078 5 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 127512049 Common - ATPase, BadF/BadG/BcrA/BcrD type Shew_1116 47 COG2971 COG2971, Predicted N-acetylglucosamine kinase Carbohydrate transport and metabolism 127512054 Common - hypothetical protein Shew_1121 117 COG2353 COG2353, Uncharacterized conserved protein Function unknown 127513674 Nonpathogen - hypothetical protein Shew_2746 2 None None None 127512708 Common - Glutathione S-transferase, N-terminal domain Shew_1780 39 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 127513708 Common - thioesterase superfamily protein Shew_2780 77 COG0824 FcbC, Predicted thioesterase General function prediction only 127511282 Common - cytochrome c, putative Shew_0348 9 None None None 127513860 Common - nicotinate (nicotinamide) nucleotide adenylyltransferase Shew_2932 186 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 127514293 Common - acetyl-CoA carboxylase, biotin carboxylase Shew_3365 232 COG0439 AccC, Biotin carboxylase Lipid metabolism 127512720 Common - OmpA/MotB domain protein Shew_1792 143 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 127510969 Common - Methyltransferase type 12 Shew_0034 38 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 127513271 Nonpathogen - hypothetical protein Shew_2343 1 None None None 127513535 Common - putative branched-chain amino acid ABC transporter Shew_2607 57 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 127514076 Common - transcriptional regulator, MarR family Shew_3148 23 COG1846 MarR, Transcriptional regulators Transcription 127512918 Common - heavy metal translocating P-type ATPase Shew_1990 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 127514685 Common - urocanate hydratase Shew_3757 97 COG2987 HutU, Urocanate hydratase Amino acid transport and metabolism 127514115 Common - hypothetical protein Shew_3187 21 None None None 127512828 Common asnC asparaginyl-tRNA synthetase Shew_1900 219 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 127514275 Common - hypothetical protein Shew_3347 22 None None None 127514124 Common - D-3-phosphoglycerate dehydrogenase Shew_3196 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 127514525 Common - inner membrane protein YjeH Shew_3597 154 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 127513319 Common pflA pyruvate formate lyase-activating enzyme 1 Shew_2391 99 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 127513717 Common - hypothetical protein Shew_2789 1 COG3371 COG3371, Predicted membrane protein Function unknown 127512984 Common - SEC-C motif domain protein Shew_2056 88 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 127514756 Common - transposon Tn7 transposition protein TnsA Shew_3828 18 None None None 127513933 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Shew_3005 98 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 127513680 Common - peptidase M61 domain protein Shew_2752 57 COG3975 COG3975, Predicted protease with the C-terminal PDZ domain General function prediction only 127514537 Common - type II secretion system protein N Shew_3609 10 None None None 127514594 Common - protein of unknown function DUF785 Shew_3666 39 COG4067 COG4067, Uncharacterized protein conserved in archaea Posttranslational modification, protein turnover, chaperones 127512718 Common - integral membrane sensor signal transduction histidine kinase Shew_1790 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127512825 Common - hypothetical protein Shew_1897 11 None None None 127513211 Common - porin, Gram-negative type Shew_2283 24 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 127513645 Nonpathogen - hypothetical protein Shew_2717 2 None None None 127513987 Nonpathogen - hypothetical protein Shew_3059 2 None None None 127514380 Common - UDP-N-acetylmuramate--alanine ligase Shew_3452 209 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 127511895 Common - hypothetical protein Shew_0962 1 None None None 127514412 Common slmA nucleoid occlusion protein Shew_3484 52 COG1309 AcrR, Transcriptional regulator Transcription 127511909 Common - binding-protein-dependent transport systems inner membrane component Shew_0976 198 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 127514742 Common - naphthoate synthase Shew_3814 175 COG0447 MenB, Dihydroxynaphthoic acid synthase Coenzyme metabolism 127512624 Common - hypothetical protein Shew_1695 3 None None None 127511831 Common - MltA-interacting MipA family protein Shew_0898 23 COG3713 OmpV, Outer membrane protein V Cell envelope biogenesis, outer membrane 127511017 Common - MOSC domain containing protein Shew_0083 78 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 127511150 Common - DNA adenine methylase Shew_0216 99 COG0338 Dam, Site-specific DNA methylase DNA replication, recombination, and repair 127513329 Common - protein of unknown function DUF214 Shew_2401 86 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 127510953 Common fadA 3-ketoacyl-CoA thiolase Shew_0018 187 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 127511200 Common - protein of unknown function DUF1107 Shew_0266 5 None None None 127513223 Common - transcriptional regulator, AraC family Shew_2295 115 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 127512165 Common - hypothetical protein Shew_1233 5 None None None 127514231 Common - protein of unknown function DUF140 Shew_3303 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 127511305 Common - transcriptional regulator, AraC family Shew_0371 136 COG3449 COG3449, DNA gyrase inhibitor DNA replication, recombination, and repair 127514578 Common - Lytic transglycosylase, catalytic Shew_3650 176 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 127512671 Common - methyl-accepting chemotaxis protein Shew_1742 5 None None None 127512839 Common - hypothetical protein Shew_1911 158 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 127511023 Common moaC molybdenum cofactor biosynthesis protein C Shew_0089 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 127512437 Common - extracellular solute-binding protein, family 3 Shew_1508 13 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 127512948 Common - seryl-tRNA synthetase Shew_2020 244 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 127511869 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Shew_0936 11 None None None 127511889 Common - peptidylprolyl isomerase, FKBP-type Shew_0956 138 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 127514544 Common - general secretion pathway protein G Shew_3616 101 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 127511395 Nonpathogen - hypothetical protein Shew_0461 1 None None None 127512159 Common - glutamate--cysteine ligase Shew_1227 58 COG2918 GshA, Gamma-glutamylcysteine synthetase Coenzyme metabolism 127512550 Common - agmatinase Shew_1621 153 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 127511355 Nonpathogen - phage shock protein C, PspC Shew_0421 1 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 127513492 Common - MltA-interacting MipA family protein Shew_2564 29 COG3713 OmpV, Outer membrane protein V Cell envelope biogenesis, outer membrane 127513749 Common - lipoprotein NlpI Shew_2821 49 COG4785 NlpI, Lipoprotein NlpI, contains TPR repeats General function prediction only 127513664 Common - transcriptional regulator, MarR family Shew_2736 89 COG1846 MarR, Transcriptional regulators Transcription 127510942 Common - urea amidolyase related protein Shew_0007 115 COG1984 DUR1, Allophanate hydrolase subunit 2 Amino acid transport and metabolism 127513024 Common - thiamine biosynthesis protein ThiC Shew_2096 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 127512557 Common - acylphosphatase Shew_1628 106 COG1254 AcyP, Acylphosphatases Energy production and conversion 127511080 Common - NusG antitermination factor Shew_0146 215 COG0250 NusG, Transcription antiterminator Transcription 127512698 Common - periplasmic nitrate reductase, large subunit Shew_1770 186 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 127511144 Common - Pilus assembly protein, PilO Shew_0210 50 COG3167 PilO, Tfp pilus assembly protein PilO Cell motility and secretion / Intracellular trafficking and secretion 127514554 Nonpathogen - hypothetical protein Shew_3626 1 None None None 127512135 Common mazG nucleoside triphosphate pyrophosphohydrolase Shew_1203 157 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 127511328 Common - hypothetical protein Shew_0394 1 None None None 127514674 Common - multiple antibiotic resistance (MarC)-related protein Shew_3746 141 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 127513672 Common - putative esterase Shew_2744 35 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 127511754 Common - hypothetical protein Shew_0820 46 COG4637 COG4637, Predicted ATPase General function prediction only 127514188 Common - porin, Gram-negative type Shew_3260 28 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 127511055 Nonpathogen - hypothetical protein Shew_0121 1 None None None 127511875 Common - RDD domain containing protein Shew_0942 22 COG1714 COG1714, Predicted membrane protein/domain Function unknown 127512379 Common - putative cytochrome P460 Shew_1450 12 None None None 127514717 Common - ABC-type nitrate/sulfonate/bicarbonate transport system protein Shew_3789 55 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 127512686 Common - hydrogenase assembly chaperone hypC/hupF Shew_1758 62 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 127512784 Common - 3-deoxy-manno-octulosonate cytidylyltransferase Shew_1856 150 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 127512483 Common - hypothetical protein Shew_1554 1 None None None 127511989 Common - DNA repair protein RecO Shew_1056 61 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 127512000 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Shew_1067 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 127511737 Common - integral membrane sensor signal transduction histidine kinase Shew_0803 212 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127513828 Common - protein of unknown function DUF1704 Shew_2900 17 COG3930 COG3930, Uncharacterized protein conserved in bacteria Function unknown 127511425 Common - hypothetical protein Shew_0491 5 None None None 127514341 Common - phosphoribosylamine--glycine ligase Shew_3413 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 127514394 Common - glycerol kinase Shew_3466 178 COG0554 GlpK, Glycerol kinase Energy production and conversion 127511817 Common - aminoglycoside phosphotransferase Shew_0883 89 COG3178 COG3178, Predicted phosphotransferase related to Ser/Thr protein kinases General function prediction only 127513730 Common - periplasmic sensory protein associated with the TorRS two-component regulatory system Shew_2802 14 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 127511420 Common - permease Shew_0486 84 COG0701 COG0701, Predicted permeases General function prediction only 127513568 Common purU formyltetrahydrofolate deformylase Shew_2640 220 COG0788 PurU, Formyltetrahydrofolate hydrolase Nucleotide transport and metabolism 127511695 Common - hypothetical protein Shew_0761 1 None None None 127513437 Common tig trigger factor Shew_2509 216 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 127512837 Common - 2OG-Fe(II) oxygenase Shew_1909 30 COG3751 EGL-9, Predicted proline hydroxylase Posttranslational modification, protein turnover, chaperones 127511342 Common - hypothetical protein Shew_0408 55 COG3164 COG3164, Predicted membrane protein Function unknown 127514221 Common rpsI 30S ribosomal protein S9 Shew_3293 249 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 127511657 Common - ABC transporter-related protein Shew_0723 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 127513794 Common - acyl-CoA synthetase Shew_2866 222 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127514781 Common - tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA Shew_3856 192 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 127512810 Common - metal dependent phosphohydrolase Shew_1882 122 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 127512150 Common - carbon storage regulator, CsrA Shew_1218 80 COG1551 CsrA, Carbon storage regulator (could also regulate swarming and quorum sensing) Signal transduction mechanisms 127512794 Common - Phosphotransferase system, phosphocarrier protein HPr Shew_1866 103 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 127511770 Common - membrane lipoprotein lipid attachment site Shew_0836 42 COG3417 FlgN, Collagen-binding surface adhesin SpaP (antigen I/II family) General function prediction only 127514228 Common - anti-sigma-factor antagonist Shew_3300 16 COG3113 COG3113, Predicted NTP binding protein (contains STAS domain) General function prediction only 127513362 Common - hypothetical protein Shew_2434 7 None None None 127512435 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Shew_1506 32 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 127513622 Common - Propeptide, PepSY amd peptidase M4 Shew_2694 2 COG3212 COG3212, Predicted membrane protein Function unknown 127512061 Common - transcriptional regulator, LysR family Shew_1128 187 COG0583 LysR, Transcriptional regulator Transcription 127513427 Common - binding-protein-dependent transport systems inner membrane component Shew_2499 217 COG4168 SapB, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 127512411 Common - amine oxidase Shew_1482 67 COG2907 COG2907, Predicted NAD/FAD-binding protein General function prediction only 127514487 Common - hypothetical protein Shew_3559 16 None None None 127513647 Common - hypothetical protein Shew_2719 13 None None None 127512370 Common - major facilitator superfamily MFS_1 Shew_1441 113 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 127511357 Common - transcriptional regulator, MerR family Shew_0423 78 COG0789 SoxR, Predicted transcriptional regulators Transcription 127513183 Common - tryptophan synthase subunit beta Shew_2255 224 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 127514354 Common - Endothelin-converting enzyme 1 Shew_3426 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 127513891 Common - protein of unknown function DUF1456 Shew_2963 31 COG4807 COG4807, Uncharacterized protein conserved in bacteria Function unknown 127511284 Common - peptidylprolyl isomerase, FKBP-type Shew_0350 134 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 127513787 Common - Phosphoglycerate mutase Shew_2859 26 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 127514476 Nonpathogen - hypothetical protein Shew_3548 1 None None None 127511246 Common - ABC transporter-related protein Shew_0312 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 127513061 Common ddl D-alanyl-alanine synthetase A Shew_2133 209 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 127513701 Common - NAD(+) kinase Shew_2773 237 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 127513083 Common - 4-hydroxyphenylpyruvate dioxygenase Shew_2155 76 COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins Amino acid transport and metabolism / General function prediction only 127511270 Common - transcriptional regulator, LysR family Shew_0336 170 COG0583 LysR, Transcriptional regulator Transcription 127514671 Common - Chorismate lyase Shew_3743 49 COG3161 UbiC, 4-hydroxybenzoate synthetase (chorismate lyase) Coenzyme metabolism 127511799 Common - Cupin 2, conserved barrel domain protein Shew_0865 47 COG3837 COG3837, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 127511386 Common - diguanylate cyclase Shew_0452 179 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 127511296 Common - signal peptidase I Shew_0362 203 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 127514518 Common - hypothetical protein Shew_3590 1 None None None 127513420 Common - hypothetical protein Shew_2492 39 COG3768 COG3768, Predicted membrane protein Function unknown 127513252 Common - type IV pilus assembly PilZ Shew_2324 2 None None None 127512680 Common - Proprotein convertase, P Shew_1752 85 COG4935 COG4935, Regulatory P domain of the subtilisin-like proprotein convertases and other proteases Posttranslational modification, protein turnover, chaperones 127511173 Common - formate dehydrogenase, gamma subunit Shew_0239 62 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 127513874 Common - hypothetical protein Shew_2946 5 None None None 127511958 Common - hypothetical protein Shew_1025 19 None None None 127512331 Common - lipopolysaccharide biosynthesis protein Shew_1400 25 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 127512566 Common - DNA internalization-related competence protein ComEC/Rec2 Shew_1637 167 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 127514490 Common - transcriptional regulator, LysR family Shew_3562 191 COG0583 LysR, Transcriptional regulator Transcription 127512819 Common - Fmu (Sun) domain protein Shew_1891 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 127511110 Common - ribosomal protein L30 Shew_0176 163 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 127514157 Common - hypothetical protein Shew_3229 8 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 127513813 Common - 2OG-Fe(II) oxygenase Shew_2885 41 COG3145 AlkB, Alkylated DNA repair protein DNA replication, recombination, and repair 127511944 Common - Citrate transporter Shew_1011 47 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 127513818 Common - peptidyl-prolyl cis-trans isomerase, cyclophilin type Shew_2890 187 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 127511949 Common - hypothetical protein Shew_1016 16 None None None 127511071 Common - DNA-binding transcriptional repressor FabR Shew_0137 53 COG1309 AcrR, Transcriptional regulator Transcription 127512895 Common - amidohydrolase Shew_1967 89 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 127512348 Common - UTP-glucose-1-phosphate uridylyltransferase GalU Shew_1418 230 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 127514665 Common - methionyl-tRNA formyltransferase Shew_3737 222 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 127513908 Common - protein of unknown function DUF1458 Shew_2980 39 COG3360 COG3360, Uncharacterized conserved protein Function unknown 127512581 Common - conserved hypothetical succinate dehydrogenase, hydrophobic subunit Shew_1652 53 COG2142 SdhD, Succinate dehydrogenase, hydrophobic anchor subunit Energy production and conversion 127512064 Common - putative oxygen-independent coproporphyrinogen III oxidase Shew_1131 205 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 127514697 Common - hypothetical protein Shew_3769 7 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 127512490 Common - NUDIX hydrolase Shew_1561 52 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 127513742 Common deoA thymidine phosphorylase Shew_2814 118 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 127513505 Common - methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor Shew_2577 157 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127512616 Common - hypothetical protein Shew_1687 2 None None None 127514205 Common alr alanine racemase Shew_3277 200 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 127511717 Common - Pseudouridylate synthase Shew_0783 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 127513284 Common - Patatin Shew_2356 46 COG4667 COG4667, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 127513381 Common - hypothetical protein Shew_2453 11 None None None 127511443 Common - hypothetical protein Shew_0509 4 None None None 127514723 Common - transmembrane pair domain protein Shew_3795 41 COG4125 COG4125, Predicted membrane protein Function unknown 127514644 Common - cytochrome c, class I Shew_3716 63 COG2863 COG2863, Cytochrome c553 Energy production and conversion 127513001 Common - lactoylglutathione lyase Shew_2073 124 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 127511768 Nonpathogen - hypothetical protein Shew_0834 1 None None None 127512638 Common - hypothetical protein Shew_1709 26 None None None 127514680 Common - MscS Mechanosensitive ion channel Shew_3752 79 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 127512961 Nonpathogen - hypothetical protein Shew_2033 1 None None None 127513008 Common - diguanylate cyclase Shew_2080 202 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127511115 Common - 30S ribosomal protein S11 Shew_0181 247 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 127513996 Common - protein of unknown function DUF710 Shew_3068 56 COG3027 COG3027, Uncharacterized protein conserved in bacteria Function unknown 127512644 Common - peptide synthase Shew_1715 214 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127511708 Common - peptidase S9B, dipeptidylpeptidase IV domain protein Shew_0774 109 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 127511288 Common - NosL family protein Shew_0354 30 COG4314 NosL, Predicted lipoprotein involved in nitrous oxide reduction Energy production and conversion 127510945 Common glyQ glycyl-tRNA synthetase subunit alpha Shew_0010 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 127511211 Common - transcriptional regulator, TetR family Shew_0277 5 COG1309 AcrR, Transcriptional regulator Transcription 127512273 Common flgA flagellar basal body P-ring biosynthesis protein FlgA Shew_1342 34 COG1261 FlgA, Flagellar basal body P-ring biosynthesis protein Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 127511564 Common - conserved hypothetical protein 245 Shew_0630 70 COG0390 COG0390, ABC-type uncharacterized transport system, permease component General function prediction only 127511921 Common - hypothetical protein Shew_0988 13 None None None 127512237 Common - HNH endonuclease Shew_1305 3 None None None 127513196 Common - protein of unknown function DUF182 Shew_2268 82 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 127514431 Common - Na+/Ca+ antiporter, CaCA family Shew_3503 112 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 127511068 Common - tRNA 2-selenouridine synthase Shew_0134 65 COG2603 COG2603, Predicted ATPase General function prediction only 127513616 Common - amidohydrolase Shew_2688 169 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 127514368 Common - Prepilin peptidase Shew_3440 127 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 127511475 Common - protein of unknown function DUF461 Shew_0541 82 COG2847 COG2847, Uncharacterized protein conserved in bacteria Function unknown 127513019 Common thiH thiamine biosynthesis protein ThiH Shew_2091 57 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 127511397 Common - hypothetical protein Shew_0463 3 None None None 127511060 Common - hypothetical protein Shew_0126 25 COG5404 SulA, SOS-response cell division inhibitor, blocks FtsZ ring formation Cell division and chromosome partitioning 127514633 Common - dTDP-4-dehydrorhamnose reductase Shew_3705 162 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 127511191 Common - peptidase S9, prolyl oligopeptidase active site domain protein Shew_0257 115 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 127512975 Common - 6-phosphogluconolactonase Shew_2047 116 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 127514535 Common - putative methyltransferase Shew_3607 207 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 127511119 Common - hypothetical protein Shew_0185 22 None None None 127511279 Common - Redoxin domain protein Shew_0345 144 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 127513772 Common - chaperone protein DnaK Shew_2844 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 127511774 Common - peptidylprolyl isomerase, FKBP-type Shew_0840 137 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 127514512 Common - hypothetical protein Shew_3584 1 None None None 127513353 Common fadJ multifunctional fatty acid oxidation complex subunit alpha Shew_2425 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 127513482 Common - outer membrane protein W Shew_2554 73 COG3047 OmpW, Outer membrane protein W Cell envelope biogenesis, outer membrane 127511597 Common - oxidoreductase Shew_0663 107 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 127513924 Nonpathogen - hypothetical protein Shew_2996 2 None None None 127514363 Common - nicotinate-nucleotide pyrophosphorylase Shew_3435 204 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 127514458 Common - glycerol-3-phosphate acyltransferase Shew_3530 48 COG2937 PlsB, Glycerol-3-phosphate O-acyltransferase Lipid metabolism 127512317 Common - CheA signal transduction histidine kinase Shew_1386 154 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 127511129 Common - cytochrome C biogenesis protein Shew_0195 92 COG3088 CcmH, Uncharacterized protein involved in biosynthesis of c-type cytochromes Posttranslational modification, protein turnover, chaperones 127514241 Common - PTS IIA-like nitrogen-regulatory protein PtsN Shew_3313 136 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 127512358 Common - protein of unknown function DUF218 Shew_1429 67 COG1434 COG1434, Uncharacterized conserved protein Function unknown 127513837 Common - GCN5-related N-acetyltransferase Shew_2909 29 COG0456 RimI, Acetyltransferases General function prediction only 127514191 Common - serine/threonine protein kinase Shew_3263 89 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 127511586 Nonpathogen - hypothetical protein Shew_0652 2 None None None 127512753 Common uvrC excinuclease ABC subunit C Shew_1825 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 127512257 Common - short-chain dehydrogenase/reductase SDR Shew_1326 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 127513458 Common - C4-dicarboxylate transporter/malic acid transport protein Shew_2530 35 COG1275 TehA, Tellurite resistance protein and related permeases Inorganic ion transport and metabolism 127514118 Common - Catalase Shew_3190 126 COG0753 KatE, Catalase Inorganic ion transport and metabolism 127514410 Common - phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase Shew_3482 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 127513552 Common - beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ Shew_2624 188 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 127511496 Common - protein of unknown function UPF0079 Shew_0562 208 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 127513010 Common - putative methyltransferase Shew_2082 63 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 127513577 Common - hypothetical protein Shew_2649 22 None None None 127513299 Common - Na+/solute symporter Shew_2371 167 COG4147 DhlC, Predicted symporter General function prediction only 127511339 Common - Rod shape-determining protein MreD Shew_0405 65 COG2891 MreD, Cell shape-determining protein Cell envelope biogenesis, outer membrane 127512808 Common - hypothetical protein Shew_1880 3 None None None 127511265 Common prmA ribosomal protein L11 methyltransferase Shew_0331 174 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 127512921 Common - fumarate/nitrate reduction transcriptional regulator Shew_1993 159 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 127513971 Common - hypothetical protein Shew_3043 30 None None None 127511381 Common - hypothetical protein Shew_0447 15 None None None 127514462 Common - heavy metal efflux pump, CzcA family Shew_3534 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 127512734 Common - protein of unknown function DUF1329 Shew_1806 19 None None None 127512515 Common - diacylglycerol kinase Shew_1586 80 COG0818 DgkA, Diacylglycerol kinase Cell envelope biogenesis, outer membrane 127511053 Common - hypothetical protein Shew_0119 15 None None None 127513517 Common - protein of unknown function UPF0066 Shew_2589 90 COG1720 COG1720, Uncharacterized conserved protein Function unknown 127513898 Common - hypothetical protein Shew_2970 1 COG2944 COG2944, Predicted transcriptional regulator Transcription 127512099 Common - 4-alpha-glucanotransferase Shew_1167 117 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 127512598 Common - Butyryl-CoA dehydrogenase Shew_1669 166 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 127513478 Common - GCN5-related N-acetyltransferase Shew_2550 125 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 127513114 Common - cell division topological specificity factor MinE Shew_2186 70 COG0851 MinE, Septum formation topological specificity factor Cell division and chromosome partitioning 127511199 Common - DSBA oxidoreductase Shew_0265 69 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 127514787 Common - Resolvase, N-terminal domain Shew_3862 128 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 127510980 Common - efflux transporter, RND family, MFP subunit Shew_0045 165 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 127514327 Common - FMN-binding domain protein Shew_3399 53 COG3901 NosR, Regulator of nitric oxide reductase transcription Transcription 127511321 Common - MSHA biogenesis protein MshJ Shew_0387 15 None None None 127513914 Common - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Shew_2986 138 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 127514259 Common - transcriptional regulator, Crp/Fnr family Shew_3331 137 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 127514776 Common - F0F1 ATP synthase subunit A Shew_3851 207 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 127511960 Common - Methylthioadenosine nucleosidase Shew_1027 107 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 127513167 Common - hypothetical protein Shew_2239 15 COG3219 COG3219, Uncharacterized protein conserved in bacteria Function unknown 127514189 Common - thiopurine S-methyltransferase Shew_3261 33 None None None 127511090 Common - elongation factor Tu Shew_0156 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 127512690 Common - hydrogenase expression/formation protein Shew_1762 64 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 127512226 Common engA GTP-binding protein EngA Shew_1294 231 COG1160 COG1160, Predicted GTPases General function prediction only 127512092 Common - hypothetical protein Shew_1160 2 None None None 127511104 Common rplE 50S ribosomal protein L5 Shew_0170 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 127513592 Common - transcriptional regulator, putative Shew_2664 28 COG5240 SEC21, Vesicle coat complex COPI, gamma subunit Intracellular trafficking and secretion 127511349 Common - hypothetical protein Shew_0415 53 COG3028 COG3028, Uncharacterized protein conserved in bacteria Function unknown 127513387 Common - hypothetical protein Shew_2459 6 None None None 127511121 Common - Heme exporter protein D (CcmD) Shew_0187 25 COG3114 CcmD, Heme exporter protein D Intracellular trafficking and secretion 127512029 Common rpsT 30S ribosomal protein S20 Shew_1096 210 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 127511516 Common - integral membrane sensor signal transduction histidine kinase Shew_0582 215 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127512523 Common - pseudouridine synthase, RluA family Shew_1594 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 127512968 Common - diguanylate cyclase Shew_2040 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 127513453 Common - decaheme cytochrome c Shew_2525 7 None None None 127513050 Common - putative sulfite oxidase subunit YedZ Shew_2122 73 COG2717 COG2717, Predicted membrane protein Function unknown 127513855 Common - apolipoprotein N-acyltransferase Shew_2927 165 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 127512992 Common - excinuclease ABC subunit B Shew_2064 229 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 127511605 Common - Phospholipase A(1) Shew_0671 52 COG2829 PldA, Outer membrane phospholipase A Cell envelope biogenesis, outer membrane 127511742 Common - methyl-accepting chemotaxis sensory transducer Shew_0808 153 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127514710 Common - ABC-2 type transporter Shew_3782 40 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 127511825 Common - AAA ATPase, central domain protein Shew_0892 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 127511714 Common - Succinylglutamate desuccinylase/aspartoacylase Shew_0780 30 COG3608 COG3608, Predicted deacylase General function prediction only 127513391 Common - hypothetical protein Shew_2463 2 None None None 127512631 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Shew_1702 1 None None None 127513722 Common - CBS domain containing protein Shew_2794 95 COG0517 COG0517, FOG: CBS domain General function prediction only 127511758 Common - NAD-dependent epimerase/dehydratase Shew_0824 63 COG2910 COG2910, Putative NADH-flavin reductase General function prediction only 127514016 Common - short chain fatty acid transporter Shew_3088 40 COG2031 AtoE, Short chain fatty acids transporter Lipid metabolism 127511628 Common - protein of unknown function DUF6, transmembrane Shew_0694 30 COG2962 RarD, Predicted permeases General function prediction only 127514173 Common - Polysulphide reductase, NrfD Shew_3245 15 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 127511604 Common - hypothetical protein Shew_0670 1 None None None 127511741 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Shew_0807 46 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 127511646 Common - ABC transporter-related protein Shew_0712 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 127511678 Common - protein of unknown function DUF306, Meta and HslJ Shew_0744 32 COG3187 HslJ, Heat shock protein Posttranslational modification, protein turnover, chaperones 127511747 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Shew_0813 196 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 127513164 Common - adenine phosphoribosyltransferase Shew_2236 192 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 127513444 Common - glutaminyl-tRNA synthetase Shew_2516 237 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 127511135 Common - acetylornithine deacetylase Shew_0201 207 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 127511254 Common - Frataxin family protein Shew_0320 40 COG1965 CyaY, Protein implicated in iron transport, frataxin homolog Inorganic ion transport and metabolism 127512512 Common yebU rRNA (cytosine-C(5)-)-methyltransferase RsmF Shew_1583 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 127513165 Common - protein of unknown function DUF454 Shew_2237 50 COG2832 COG2832, Uncharacterized protein conserved in bacteria Function unknown 127514404 Common - RarD protein, DMT superfamily transporter Shew_3476 109 COG2962 RarD, Predicted permeases General function prediction only 127511738 Common - two component transcriptional regulator, winged helix family Shew_0804 214 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127510987 Common - DNA binding domain, excisionase family Shew_0052 59 COG1910 COG1910, Periplasmic molybdate-binding protein/domain Inorganic ion transport and metabolism 127512330 Common - polysaccharide export protein Shew_1399 114 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 127514413 Common - peptidase S9, prolyl oligopeptidase active site domain protein Shew_3485 111 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 127513888 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Shew_2960 52 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 127513110 Common - putative transglycosylase Shew_2182 100 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 127514171 Common - molydopterin dinucleotide-binding region Shew_3243 71 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 127513240 Common - ferredoxin, 2Fe-2S type, ISC system Shew_2312 78 COG0633 Fdx, Ferredoxin Energy production and conversion 127513738 Common - phosphoserine phosphatase SerB Shew_2810 146 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 127512352 Common - sulfate adenylyltransferase, large subunit Shew_1423 249 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 127514465 Common - hypothetical protein Shew_3537 1 None None None 127513452 Common - decaheme cytochrome c Shew_2524 8 COG5273 COG5273, Uncharacterized protein containing DHHC-type Zn finger General function prediction only 127511406 Common groEL chaperonin GroEL Shew_0472 246 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 127511625 Common - protein of unknown function UPF0118 Shew_0691 153 COG0628 PerM, Predicted permease General function prediction only 127512405 Common - RNA polymerase sigma factor Shew_1476 124 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 127511448 Common - cytochrome c, putative Shew_0514 20 None None None 127514636 Common - transcriptional regulator, TetR family Shew_3708 55 COG1309 AcrR, Transcriptional regulator Transcription 127511773 Common - WD-40 repeat protein Shew_0839 43 COG2319 COG2319, FOG: WD40 repeat General function prediction only 127511124 Common - heme exporter protein CcmA Shew_0190 249 COG4133 CcmA, ABC-type transport system involved in cytochrome c biogenesis, ATPase component Posttranslational modification, protein turnover, chaperones 127513554 Common - outer membrane chaperone Skp (OmpH) Shew_2626 80 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 127513881 Common - diguanylate cyclase Shew_2953 180 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127513273 Common - binding-protein-dependent transport systems inner membrane component Shew_2345 85 COG3639 COG3639, ABC-type phosphate/phosphonate transport system, permease component Inorganic ion transport and metabolism 127513903 Common - pseudouridine synthase Shew_2975 202 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 127513117 Common - alpha/beta hydrolase fold Shew_2189 29 COG2267 PldB, Lysophospholipase Lipid metabolism 127513576 Common - GCN5-related N-acetyltransferase Shew_2648 7 None None None 127512594 Common - peptidase S51, dipeptidase E Shew_1665 9 COG3340 PepE, Peptidase E Amino acid transport and metabolism 127512695 Common - ATP-dependent helicase HrpA Shew_1767 137 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 127514246 Common - integral membrane sensor signal transduction histidine kinase Shew_3318 186 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127511722 Common - dienelactone hydrolase Shew_0788 63 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 127511633 Common - Na+/H+ antiporter Shew_0699 47 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 127514355 Common - Patatin Shew_3427 123 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 127511198 Common - predicted kinase Shew_0264 54 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 127512259 Common - acylneuraminate cytidylyltransferase Shew_1328 92 COG1861 SpsF, Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog Cell envelope biogenesis, outer membrane 127514539 Common - general secretion pathway protein L Shew_3611 29 COG3297 PulL, Type II secretory pathway, component PulL Intracellular trafficking and secretion 127512733 Common - protein of unknown function DUF1302 Shew_1805 18 None None None 127514733 Common - Rhodanese domain protein Shew_3805 148 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 127512519 Common - 2OG-Fe(II) oxygenase Shew_1590 55 COG3491 PcbC, Isopenicillin N synthase and related dioxygenases General function prediction only 127514320 Common - Ornithine decarboxylase Shew_3392 215 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 127514772 Common - F0F1 ATP synthase subunit alpha Shew_3847 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 127513833 Common - protein of unknown function DUF819 Shew_2905 21 COG5505 COG5505, Predicted integral membrane protein Function unknown 127513005 Common - crossover junction endodeoxyribonuclease RuvC Shew_2077 195 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 127510977 Common - Ferritin, Dps family protein Shew_0042 84 COG1528 Ftn, Ferritin-like protein Inorganic ion transport and metabolism 127513026 Common - channel protein, hemolysin III family Shew_2098 119 COG1272 COG1272, Predicted membrane protein, hemolysin III homolog General function prediction only 127513976 Common - Alcohol dehydrogenase GroES domain protein Shew_3048 203 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 127511749 Common - glucosamine-6-phosphate isomerase Shew_0815 102 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 127513393 Common - transcriptional regulator, LysR family Shew_2465 181 COG0583 LysR, Transcriptional regulator Transcription 127513067 Common - peptidylprolyl isomerase, FKBP-type Shew_2139 129 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 127512179 Common - protein of unknown function DUF897 Shew_1247 33 COG3329 COG3329, Predicted permease General function prediction only 127512119 Common - riboflavin biosynthesis protein RibD Shew_1187 228 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 127513587 Common - protein of unknown function DUF214 Shew_2659 117 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 127512818 Common - glucose/galactose transporter Shew_1890 63 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 127511061 Common - LexA repressor Shew_0127 172 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 127513532 Common - restriction endonuclease Shew_2604 5 None None None 127512930 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Shew_2002 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 127513769 Common - peptidylprolyl isomerase, FKBP-type Shew_2841 130 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 127511662 Common - dihydroorotase Shew_0728 86 COG0418 PyrC, Dihydroorotase Nucleotide transport and metabolism 127512084 Common - OmpA/MotB domain protein Shew_1151 128 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 127512074 Common - transposase IS116/IS110/IS902 family protein Shew_1141 88 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 127514398 Common - isopropylmalate isomerase large subunit Shew_3470 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 127514436 Common - hypothetical protein Shew_3508 12 None None None 127513480 Common - hypothetical protein Shew_2552 29 COG3126 COG3126, Uncharacterized protein conserved in bacteria Function unknown 127511153 Common - Ribulose-phosphate 3-epimerase Shew_0219 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 127512689 Common - hypothetical protein Shew_1761 5 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 127513462 Common - Glycerate kinase Shew_2534 81 COG1929 COG1929, Glycerate kinase Carbohydrate transport and metabolism 127513649 Common - hypothetical protein Shew_2721 4 None None None 127511243 Common - OmpA/MotB domain protein Shew_0309 151 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 127511491 Common - phosphatidylserine decarboxylase Shew_0557 97 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 127511607 Common - hypothetical protein Shew_0673 9 None None None 127512339 Common - thiamine pyrophosphate enzyme TPP binding domain protein Shew_1408 139 COG1165 MenD, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Coenzyme metabolism 127511590 Common - anaerobic nitric oxide reductase transcription regulator Shew_0656 169 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 127511937 Common - undecaprenyl pyrophosphate phosphatase Shew_1004 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 127512124 Common - thiamine-monophosphate kinase Shew_1192 201 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 127512586 Common sucC succinyl-CoA synthetase subunit beta Shew_1657 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 127513448 Common - outer membrane protein, putative Shew_2520 9 None None None 127514583 Common - transcriptional regulator, LysR family Shew_3655 182 COG0583 LysR, Transcriptional regulator Transcription 127514459 Common - aromatic amino acid transporter Shew_3531 32 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 127513797 Common - peptidase S15 Shew_2869 70 COG2936 COG2936, Predicted acyl esterases General function prediction only 127511222 Common - ketol-acid reductoisomerase Shew_0288 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 127511003 Common - fumarate lyase Shew_0068 203 COG0114 FumC, Fumarase Energy production and conversion 127512063 Common - protein of unknown function DUF885 Shew_1130 44 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 127513060 Nonpathogen - hypothetical protein Shew_2132 1 None None None 127511097 Common rplV 50S ribosomal protein L22 Shew_0163 218 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 127512999 Common - SoxR-reducing system protein RsxE Shew_2071 76 COG4660 RnfE, Predicted NADH:ubiquinone oxidoreductase, subunit RnfE Energy production and conversion 127511216 Common - phospholipid/glycerol acyltransferase Shew_0282 35 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 127513665 Common - transcriptional regulator, AraC family Shew_2737 46 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 127513721 Common - succinyl-diaminopimelate desuccinylase Shew_2793 208 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 127514672 Common - peptidase M6, immune inhibitor A Shew_3744 59 COG4412 COG4412, Uncharacterized protein conserved in bacteria Function unknown 127514744 Common - OmpA domain protein transmembrane region-containing protein Shew_3816 1 None None None 127512525 Common - diguanylate cyclase with PAS/PAC sensor Shew_1596 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127511276 Common - hypothetical protein Shew_0342 7 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 127513249 Common - inositol monophosphatase Shew_2321 216 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 127513137 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Shew_2209 157 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 127513919 Common - protein of unknown function DUF805 Shew_2991 67 COG3152 COG3152, Predicted membrane protein Function unknown 127512963 Common - hypothetical protein Shew_2035 15 None None None 127513116 Common - long-chain-fatty-acid--CoA ligase Shew_2188 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127513912 Common - ferredoxin-dependent glutamate synthase Shew_2984 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 127513294 Common - 3-oxoacyl-(acyl carrier protein) synthase III Shew_2366 204 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 127512315 Common - response regulator receiver protein Shew_1384 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 127511190 Common - hypothetical protein Shew_0256 13 COG2930 COG2930, Uncharacterized conserved protein Function unknown 127512848 Common - alpha/beta hydrolase fold Shew_1920 166 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 127511592 Common - lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase Shew_0658 94 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 127511900 Common - Aldehyde dehydrogenase (NAD(+)) Shew_0967 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 127512959 Common - translation initiation factor IF-3 Shew_2031 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 127512682 Nonpathogen - hypothetical protein Shew_1754 1 None None None 127514187 Common - heavy metal sensor signal transduction histidine kinase Shew_3259 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127511509 Common - glutamine amidotransferase of anthranilate synthase Shew_0575 239 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 127513338 Common - beta-ketoacyl synthase Shew_2410 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127513385 Common - nuclease SbcCD, D subunit Shew_2457 137 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 127514434 Common - two component transcriptional regulator, LuxR family Shew_3506 221 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 127514019 Common - membrane-flanked domain protein Shew_3091 23 COG3402 COG3402, Uncharacterized conserved protein Function unknown 127513351 Nonpathogen - hypothetical protein Shew_2423 1 None None None 127511793 Common - Glutathione S-transferase, N-terminal domain Shew_0859 65 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 127512579 Common gltA type II citrate synthase Shew_1650 194 COG0372 GltA, Citrate synthase Energy production and conversion 127511207 Common - hypothetical protein Shew_0273 19 None None None 127513154 Common - Ig domain protein, group 1 domain protein Shew_2226 14 None None None 127513286 Common - peptidase M24 Shew_2358 222 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 127512484 Common - Glu/Leu/Phe/Val dehydrogenase, dimerisation region Shew_1555 163 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 127513371 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Shew_2443 121 COG4935 COG4935, Regulatory P domain of the subtilisin-like proprotein convertases and other proteases Posttranslational modification, protein turnover, chaperones 127511941 Common - metal dependent phosphohydrolase Shew_1008 196 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 127513470 Common - transcription activator, effector binding Shew_2542 23 COG3708 COG3708, Uncharacterized protein conserved in bacteria Function unknown 127511824 Common - methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor Shew_0891 151 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127511872 Common - leucyl aminopeptidase Shew_0939 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 127511348 Common - ABC-2 type transporter Shew_0414 46 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 127511298 Common - MshA, mannose-sensitive haemaglutinin Shew_0364 6 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 127512897 Common - two component transcriptional regulator, LuxR family Shew_1969 213 COG4566 TtrR, Response regulator Signal transduction mechanisms 127511915 Common - hypothetical protein Shew_0982 181 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 127513434 Common - ATP-dependent protease La Shew_2506 219 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 127513746 Common - TatD-related deoxyribonuclease Shew_2818 237 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 127511701 Common - ATP-dependent RNA helicase SrmB Shew_0767 242 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 127513388 Common - hypothetical protein Shew_2460 11 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 127513877 Common - protein of unknown function DUF152 Shew_2949 181 COG1496 COG1496, Uncharacterized conserved protein Function unknown 127514713 Common - transcriptional regulator, AraC family Shew_3785 133 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 127511715 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Shew_0781 78 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 127513921 Nonpathogen - hypothetical protein Shew_2993 3 None None None 127514151 Common - Deoxyribonuclease I Shew_3223 34 COG2356 EndA, Endonuclease I DNA replication, recombination, and repair 127511178 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Shew_0244 169 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 127514086 Common - Polysulphide reductase, NrfD Shew_3158 19 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 127514677 Common - hypothetical protein Shew_3749 8 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 127511160 Common - hypothetical protein Shew_0226 145 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 127513356 Common - protein of unknown function DUF58 Shew_2428 74 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 127513862 Common - hypothetical protein Shew_2934 162 COG1576 COG1576, Uncharacterized conserved protein Function unknown 127511428 Nonpathogen - hypothetical protein Shew_0494 1 None None None 127511985 Common - GTP-binding protein LepA Shew_1052 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 127511058 Common - Cytochrome-c oxidase Shew_0124 175 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 127512426 Common - protein of unknown function DUF1538 Shew_1497 23 None None None 127511927 Common - KfrAs Shew_0994 31 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 127514690 Nonpathogen - hypothetical protein Shew_3762 1 None None None 127513170 Common - dihydrouridine synthase, DuS Shew_2242 208 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 127512758 Common - ribosomal protein L25 Shew_1830 132 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 127512375 Common - TRAP dicarboxylate transporter, DctP subunit Shew_1446 97 COG1638 DctP, TRAP-type C4-dicarboxylate transport system, periplasmic component Carbohydrate transport and metabolism 127512926 Common - protein of unknown function UPF0052 and CofD Shew_1998 87 COG0391 COG0391, Uncharacterized conserved protein Function unknown 127511688 Common pgk phosphoglycerate kinase Shew_0754 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 127512043 Common - nitrogen regulatory protein P-II Shew_1110 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 127514441 Common - hypothetical protein Shew_3513 24 COG4648 COG4648, Predicted membrane protein Function unknown 127512275 Common - MCP methyltransferase, CheR-type Shew_1344 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 127512198 Common - transcriptional regulator, XRE family Shew_1266 2 COG1396 HipB, Predicted transcriptional regulators Transcription 127512057 Common trmB tRNA (guanine-N(7))-methyltransferase Shew_1124 179 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 127513177 Common - Sua5/YciO/YrdC/YwlC family protein Shew_2249 187 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 127511373 Common - CheD, stimulates methylation of MCP proteins Shew_0439 86 COG1871 CheD, Chemotaxis protein; stimulates methylation of MCP proteins Cell motility and secretion / Signal transduction mechanisms 127512304 Common fliM flagellar motor switch protein FliM Shew_1373 113 COG1868 FliM, Flagellar motor switch protein Cell motility and secretion 127514202 Common - Alcohol dehydrogenase, zinc-binding domain protein Shew_3274 163 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 127511102 Common rplN 50S ribosomal protein L14 Shew_0168 247 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 127514531 Common - RNA polymerase factor sigma-32 Shew_3603 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 127514483 Common - hypothetical protein Shew_3555 10 COG3608 COG3608, Predicted deacylase General function prediction only 127514279 Nonpathogen - hypothetical protein Shew_3351 1 None None None 127512023 Common - OmpA/MotB domain protein Shew_1090 153 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 127514104 Common - regulatory protein GntR, HTH Shew_3176 135 COG2186 FadR, Transcriptional regulators Transcription 127514333 Common - drug resistance transporter, EmrB/QacA subfamily Shew_3405 200 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 127511946 Common - aspartate carbamoyltransferase Shew_1013 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 127513751 Common - diguanylate cyclase/phosphodiesterase Shew_2823 177 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 127512622 Common - hypothetical protein Shew_1693 12 None None None 127513279 Common - metal dependent phosphohydrolase Shew_2351 122 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 127514254 Common - sodium/hydrogen exchanger Shew_3326 104 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 127514621 Common - ADP-heptose--lipooligosaccharide heptosyltransferase III Shew_3693 14 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 127514782 Common - flavodoxin Shew_3857 81 COG0716 FldA, Flavodoxins Energy production and conversion 127512786 Common - DegT/DnrJ/EryC1/StrS aminotransferase Shew_1858 194 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 127512549 Common - Adenosylmethionine decarboxylase Shew_1620 2 None None None 127512970 Common - transcriptional regulator, MarR family Shew_2042 106 COG1846 MarR, Transcriptional regulators Transcription 127513953 Common - hypothetical protein Shew_3025 8 None None None 127512261 Common - Rieske (2Fe-2S) domain protein Shew_1330 81 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 127512357 Common - fructokinase Shew_1428 131 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 127513018 Common - conserved hypothetical methyl-accepting chemotaxis protein Shew_2090 6 None None None 127514513 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Shew_3585 182 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 127512417 Common - FAD linked oxidase domain protein Shew_1488 62 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 127513136 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Shew_2208 110 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 127512151 Common - sodium pump decarboxylases, gamma subunit Shew_1219 8 COG3630 OadG, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, gamma subunit Energy production and conversion 127514342 Common - hypothetical protein Shew_3414 10 None None None 127511513 Common - Arginine N-succinyltransferase Shew_0579 37 COG3138 AstA, Arginine/ornithine N-succinyltransferase beta subunit Amino acid transport and metabolism 127511877 Common - GCN5-related N-acetyltransferase Shew_0944 22 COG3153 COG3153, Predicted acetyltransferase General function prediction only 127512875 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Shew_1947 193 COG0546 Gph, Predicted phosphatases General function prediction only 127511469 Common - single-strand binding protein Shew_0535 213 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 127512270 Common - protein of unknown function DUF400 Shew_1339 16 COG3018 COG3018, Uncharacterized protein conserved in bacteria Function unknown 127511819 Common djlA Dna-J like membrane chaperone protein Shew_0885 100 COG1076 DjlA, DnaJ-domain-containing proteins 1 Posttranslational modification, protein turnover, chaperones 127511578 Common - FHA domain containing protein Shew_0644 157 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 127514004 Common - Lysine exporter protein (LYSE/YGGA) Shew_3076 94 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 127511462 Common - Sel1 domain protein repeat-containing protein Shew_0528 86 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 127514352 Common - bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase Shew_3424 223 COG1049 AcnB, Aconitase B Energy production and conversion 127514470 Common - D-tyrosyl-tRNA deacylase Shew_3542 139 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 127513608 Common - putative ferredoxin Shew_2680 34 COG2440 FixX, Ferredoxin-like protein Energy production and conversion 127511964 Common gltD glutamate synthase subunit beta Shew_1031 214 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 127512633 Nonpathogen - hypothetical protein Shew_1704 1 None None None 127512387 Common - sodium:dicarboxylate symporter Shew_1458 150 COG3633 SstT, Na+/serine symporter Amino acid transport and metabolism 127513257 Common - putative two-component response-regulatory protein YehT Shew_2329 197 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 127513086 Common - gamma-glutamyltransferase Shew_2158 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 127511249 Common - HemY domain protein Shew_0315 39 COG3071 HemY, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 127514473 Common rbn ribonuclease BN Shew_3545 154 COG1295 Rbn, Predicted membrane protein Function unknown 127513601 Common caiC putative crotonobetaine/carnitine-CoA ligase Shew_2673 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127511585 Nonpathogen - hypothetical protein Shew_0651 2 None None None 127513943 Common - gamma-glutamyl phosphate reductase Shew_3015 187 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 127512797 Common - hypothetical protein Shew_1869 10 None None None 127511716 Common - DNA-binding transcriptional regulator AsnC Shew_0782 157 COG1522 Lrp, Transcriptional regulators Transcription 127514391 Nonpathogen - PepSY-associated TM helix domain protein Shew_3463 10 None None None 127512201 Common - cyclase/dehydrase Shew_1269 102 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 127513368 Common - acriflavin resistance protein Shew_2440 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 127511953 Common anmK anhydro-N-acetylmuramic acid kinase Shew_1020 120 COG2377 COG2377, Predicted molecular chaperone distantly related to HSP70-fold metalloproteases Posttranslational modification, protein turnover, chaperones 127514645 Common - hypothetical protein Shew_3717 18 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 127511922 Common - MobA/MobL protein Shew_0989 35 None None None 127512258 Common - hypothetical protein Shew_1327 7 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127513854 Common - CBS domain containing protein Shew_2926 219 COG4535 CorC, Putative Mg2+ and Co2+ transporter CorC Inorganic ion transport and metabolism 127513317 Common - hypothetical protein Shew_2389 9 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 127514109 Common - fumarate reductase/succinate dehydrogenase flavoprotein domain protein Shew_3181 54 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 127512820 Common - SNF2-related protein Shew_1892 137 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 127512453 Common - MotA/TolQ/ExbB proton channel Shew_1524 150 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 127512448 Common - hypothetical protein Shew_1519 10 None None None 127514298 Common - ribonuclease activity regulator protein RraA Shew_3370 84 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 127513489 Common - 6-phosphogluconate dehydrogenase Shew_2561 150 COG0362 Gnd, 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 127514141 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Shew_3213 20 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 127512563 Common - lipoprotein releasing system, transmembrane protein, LolC/E family Shew_1634 154 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 127514137 Common - Nitrate reductase cytochrome c-type subunit (NapB) Shew_3209 40 COG3043 NapB, Nitrate reductase cytochrome c-type subunit Energy production and conversion 127511423 Nonpathogen - hypothetical protein Shew_0489 2 None None None 127511341 Common - ribonuclease G Shew_0407 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 127511327 Common - type II secretion system protein Shew_0393 141 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 127512947 Common - hypothetical protein Shew_2019 1 None None None 127511884 Common - response regulator receiver modulated diguanylate phosphodiesterase Shew_0951 166 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 127514311 Nonpathogen - hypothetical protein Shew_3383 1 None None None 127511005 Common - iron-containing alcohol dehydrogenase Shew_0070 169 COG1979 COG1979, Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family Energy production and conversion 127513890 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) Shew_2962 201 COG0281 SfcA, Malic enzyme Energy production and conversion 127511289 Common - periplasmic copper-binding Shew_0355 49 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 127511359 Common - ABC-2 type transporter Shew_0425 190 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 127512790 Common - succinyl-diaminopimelate desuccinylase Shew_1862 212 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 127511287 Common - Polysulphide reductase, NrfD Shew_0353 22 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 127510958 Common - Protoporphyrinogen oxidase Shew_0023 36 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 127514301 Common - ubiquinone/menaquinone biosynthesis methyltransferase Shew_3373 217 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 127513259 Common - YaeQ family protein Shew_2331 52 COG4681 COG4681, Uncharacterized protein conserved in bacteria Function unknown 127514755 Common - transposon Tn7 transposition protein TnsB Shew_3827 47 None None None 127511838 Common - response regulator receiver protein Shew_0905 221 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 127512834 Common - GCN5-related N-acetyltransferase Shew_1906 40 COG3153 COG3153, Predicted acetyltransferase General function prediction only 127513523 Common - hypothetical protein Shew_2595 5 None None None 127511797 Common - ABC transporter-related protein Shew_0863 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 127513951 Common - diguanylate cyclase Shew_3023 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 127511533 Common - hypothetical protein Shew_0599 18 COG3541 COG3541, Predicted nucleotidyltransferase General function prediction only 127514102 Common - transcriptional regulator, LysR family Shew_3174 90 COG0583 LysR, Transcriptional regulator Transcription 127514595 Common - MgtE integral membrane region Shew_3667 152 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 127513653 Common - PfkB domain protein Shew_2725 164 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 127513092 Common - acyl-CoA dehydrogenase domain protein Shew_2164 146 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 127513250 Common - NnrS family protein Shew_2322 56 COG3213 NnrS, Uncharacterized protein involved in response to NO Inorganic ion transport and metabolism 127514687 Common - imidazolonepropionase Shew_3759 104 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 127513219 Common - protein of unknown function DUF606 Shew_2291 23 COG3238 COG3238, Uncharacterized protein conserved in bacteria Function unknown 127512399 Common - sulfatase Shew_1470 34 COG3083 COG3083, Predicted hydrolase of alkaline phosphatase superfamily General function prediction only 127512776 Common - dihydrodipicolinate synthase Shew_1848 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 127514291 Common - 3-dehydroquinate dehydratase, type II Shew_3363 169 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 127512052 Common - glucose/galactose transporter Shew_1119 48 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 127511046 Common - CheW protein Shew_0112 131 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 127512423 Common - hypothetical protein Shew_1494 16 COG3097 COG3097, Uncharacterized protein conserved in bacteria Function unknown 127511837 Common - GPR1/FUN34/yaaH family protein Shew_0904 52 COG1584 COG1584, Predicted membrane protein Function unknown 127513216 Common - galactose-1-phosphate uridylyltransferase Shew_2288 79 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 127512007 Common - cytochrome B561 Shew_1074 48 COG3658 COG3658, Cytochrome b Energy production and conversion 127512764 Common - uracil-xanthine permease Shew_1836 125 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 127512213 Common - hypothetical protein Shew_1281 90 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 127514499 Common - integral membrane sensor signal transduction histidine kinase Shew_3571 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127513938 Common - hypothetical protein Shew_3010 8 None None None 127511862 Nonpathogen - Ig family protein Shew_0929 4 None None None 127512913 Common - cytochrome c oxidase, cbb3-type, subunit I Shew_1985 152 COG3278 CcoN, Cbb3-type cytochrome oxidase, subunit 1 Posttranslational modification, protein turnover, chaperones 127511438 Common - NnrS family protein Shew_0504 53 COG3213 NnrS, Uncharacterized protein involved in response to NO Inorganic ion transport and metabolism 127512112 Common - hypothetical protein Shew_1180 1 None None None 127511338 Common - rod shape-determining protein MreC Shew_0404 119 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 127511987 Common - Ribonuclease III Shew_1054 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 127513094 Common - hypothetical protein Shew_2166 13 None None None 127514148 Common - Beta-lactamase Shew_3220 38 COG2602 COG2602, Beta-lactamase class D Defense mechanisms 127513147 Common - protein of unknown function DUF785 Shew_2219 26 COG4067 COG4067, Uncharacterized protein conserved in archaea Posttranslational modification, protein turnover, chaperones 127514575 Common - protein of unknown function DUF548 Shew_3647 52 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 127512166 Common - peptidase S41 Shew_1234 90 COG4946 COG4946, Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system Function unknown 127513698 Common - Polyprenyl synthetase Shew_2770 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 127511202 Common - transcriptional antiterminator, Rof Shew_0268 3 COG4568 Rof, Transcriptional antiterminator Transcription 127514765 Common - transcriptional regulator, DeoR family Shew_3840 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 127513693 Nonpathogen - hypothetical protein Shew_2765 1 None None None 127512941 Common - putative DNA-binding transcriptional regulator Shew_2013 171 COG0583 LysR, Transcriptional regulator Transcription 127514010 Common - sigma54 specific transcriptional regulator, Fis family Shew_3082 182 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 127514047 Common - hypothetical protein Shew_3119 8 None None None 127512535 Common - hypothetical protein Shew_1606 1 None None None 127513054 Common - ATPase associated with various cellular activities, AAA_3 Shew_2126 176 COG0714 COG0714, MoxR-like ATPases General function prediction only 127512600 Common - Enoyl-CoA hydratase/isomerase Shew_1671 136 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 127510993 Nonpathogen - twin-arginine translocation pathway signal Shew_0058 1 None None None 127514067 Nonpathogen - hypothetical protein Shew_3139 1 None None None 127514283 Common - hypothetical protein Shew_3355 15 None None None 127514034 Common - ThiJ/PfpI domain protein Shew_3106 79 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 127510989 Common - hypothetical protein Shew_0054 6 None None None 127511504 Common - ubiquinol-cytochrome c reductase, iron-sulfur subunit Shew_0570 94 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 127511887 Common - ROK family protein Shew_0954 1 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 127511218 Common - protein of unknown function DUF21 Shew_0284 217 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 127514088 Nonpathogen - hypothetical protein Shew_3160 1 None None None 127511302 Common - cytochrome c oxidase, subunit III Shew_0368 159 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 127511169 Common - isochorismatase hydrolase Shew_0235 100 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 127513835 Common - Invasion gene expression up-regulator, SirB Shew_2907 38 COG3094 COG3094, Uncharacterized protein conserved in bacteria Function unknown 127513684 Common xni exonuclease IX Shew_2756 215 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 127513209 Common - flavocytochrome c Shew_2281 208 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 127513396 Common - RNA-binding S4 domain protein Shew_2468 43 COG2501 COG2501, Uncharacterized conserved protein Function unknown 127511861 Common - transposase IS116/IS110/IS902 family protein Shew_0928 88 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 127512432 Common - Oxidoreductase FAD-binding domain protein Shew_1503 87 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 127511982 Common - anti sigma-E protein, RseA Shew_1049 26 COG3073 RseA, Negative regulator of sigma E activity Signal transduction mechanisms 127511346 Common - secretion protein HlyD family protein Shew_0412 123 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 127511812 Common apaG ApaG Shew_0878 89 COG2967 ApaG, Uncharacterized protein affecting Mg2+/Co2+ transport Inorganic ion transport and metabolism 127514296 Common - phosphoesterase, PA-phosphatase related Shew_3368 48 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 127514025 Common - TonB-dependent siderophore receptor Shew_3097 104 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 127514132 Common - cytochrome B561 Shew_3204 55 COG3658 COG3658, Cytochrome b Energy production and conversion 127512743 Common - hypothetical protein Shew_1815 4 None None None 127510975 Common - 3,4-dihydroxy-2-butanone 4-phosphate synthase Shew_0040 229 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 127513229 Common - methyl-accepting chemotaxis sensory transducer Shew_2301 153 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127514601 Nonpathogen - hypothetical protein Shew_3673 2 None None None 127514608 Common - GCN5-related N-acetyltransferase Shew_3680 5 COG3375 COG3375, Uncharacterized conserved protein Function unknown 127513981 Common - Serine-type D-Ala-D-Ala carboxypeptidase Shew_3053 125 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 127513088 Common - hypothetical protein Shew_2160 45 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 127513475 Common - pseudouridine synthase Shew_2547 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 127512880 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Shew_1952 230 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 127514081 Common - transcriptional regulator, LysR family Shew_3153 31 COG0583 LysR, Transcriptional regulator Transcription 127512006 Common - sigma 54 modulation protein/ribosomal protein S30EA Shew_1073 72 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 127512629 Common - phosphate ABC transporter, ATPase subunit Shew_1700 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 127513978 Common - hypothetical protein Shew_3050 19 COG4925 COG4925, Uncharacterized conserved protein Function unknown 127512885 Common - hypothetical protein Shew_1957 67 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 127513326 Common - protein of unknown function UPF0118 Shew_2398 176 COG0628 PerM, Predicted permease General function prediction only 127513814 Common - rRNA (guanine-N(2)-)-methyltransferase Shew_2886 97 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 127512039 Common - type IV pilin biogenesis protein, putative Shew_1106 35 COG3419 PilY1, Tfp pilus assembly protein, tip-associated adhesin PilY1 Cell motility and secretion / Intracellular trafficking and secretion 127513234 Common - tRNA pseudouridine synthase A Shew_2306 236 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 127514198 Common - SSS sodium solute transporter superfamily Shew_3270 105 COG4146 COG4146, Predicted symporter General function prediction only 127514603 Common - ABC transporter-related protein Shew_3675 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 127512645 Common - 3-beta hydroxysteroid dehydrogenase/isomerase Shew_1716 169 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 127514774 Common - F0F1 ATP synthase subunit B Shew_3849 137 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 127513566 Common dapD 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase Shew_2638 138 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 127513325 Common - hypothetical protein Shew_2397 124 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 127513603 Common - crotonobetainyl-CoA dehydrogenase Shew_2675 159 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 127513620 Common - cytochrome B561 Shew_2692 53 COG3658 COG3658, Cytochrome b Energy production and conversion 127513966 Common - asparagine synthase (glutamine-hydrolyzing) Shew_3038 159 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 127511212 Common - branched-chain amino acid aminotransferase Shew_0278 197 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 127511822 Common - hypothetical protein Shew_0889 15 None None None 127511692 Common - hypothetical protein Shew_0758 1 None None None 127514308 Common - TatD-related deoxyribonuclease Shew_3380 236 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 127513702 Common - TonB family protein Shew_2774 12 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 127512936 Common - short-chain dehydrogenase/reductase SDR Shew_2008 230 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 127511849 Common - pseudouridine synthase Shew_0916 183 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 127514566 Common envZ osmolarity sensor protein Shew_3638 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127514178 Common - peptidase T Shew_3250 61 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 127513847 Common - translation-associated GTPase Shew_2919 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 127511780 Common - nitrogen regulatory protein P-II Shew_0846 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 127514628 Common - glycosyl transferase, group 1 Shew_3700 135 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 127513508 Common - hypothetical protein Shew_2580 5 None None None 127514349 Nonpathogen - hypothetical protein Shew_3421 1 None None None 127512806 Common - 2-nitropropane dioxygenase, NPD Shew_1878 138 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 127512145 Common - RNA polymerase, sigma 70 subunit, RpoD family Shew_1213 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 127511502 Common - HflK protein Shew_0568 205 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 127514381 Common - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Shew_3453 208 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 127511853 Common - major facilitator superfamily MFS_1 Shew_0920 56 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 127514215 Nonpathogen - hypothetical protein Shew_3287 1 None None None 127514746 Common - copper-translocating P-type ATPase Shew_3818 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 127511171 Common - methyl-accepting chemotaxis sensory transducer Shew_0237 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127511239 Common - ATP-dependent DNA helicase Rep Shew_0305 231 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 127512584 Common kgd alpha-ketoglutarate decarboxylase Shew_1655 147 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 127513123 Common - NADH dehydrogenase Shew_2195 177 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 127511226 Common - dihydroxy-acid dehydratase Shew_0292 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 127513764 Common - protein of unknown function UPF0044 Shew_2836 98 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 127512827 Common - hypothetical protein Shew_1899 2 None None None 127511368 Common - hypothetical protein Shew_0434 1 None None None 127512709 Common - hypothetical protein Shew_1781 110 COG1054 COG1054, Predicted sulfurtransferase General function prediction only 127512482 Common - hypothetical protein Shew_1553 5 None None None 127511854 Common - hypothetical protein Shew_0921 4 None None None 127512407 Common - Protein of unknown function DUF1722 Shew_1478 67 COG3272 COG3272, Uncharacterized conserved protein Function unknown 127511283 Common - Rhodanese domain protein Shew_0349 15 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 127512062 Common - hypothetical protein Shew_1129 2 None None None 127514267 Common - glutathione-dependent formaldehyde-activating, GFA Shew_3339 21 COG3791 COG3791, Uncharacterized conserved protein Function unknown 127513510 Common - Na+/H+ antiporter NhaC Shew_2582 57 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 127512018 Common - response regulator receiver protein Shew_1085 219 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127514374 Common - peptidase M23B Shew_3446 188 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 127514556 Common - MgtC/SapB transporter Shew_3628 115 COG1285 SapB, Uncharacterized membrane protein Function unknown 127512170 Common - hypothetical protein Shew_1238 1 None None None 127514653 Common - carbonic anhydrase, family 3 Shew_3725 190 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 127513314 Common - hypothetical protein Shew_2386 38 COG1288 COG1288, Predicted membrane protein Function unknown 127511554 Common - ion transport 2 domain protein Shew_0620 106 None None None 127511316 Common - nuclease (SNase domain protein) Shew_0382 36 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 127513417 Common - competence protein ComEA helix-hairpin-helix repeat protein Shew_2489 152 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 127513633 Common - Na(+)-translocating NADH-quinone reductase subunit E Shew_2705 76 COG2209 NqrE, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE Energy production and conversion 127511801 Common - malate dehydrogenase Shew_0867 186 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 127514695 Nonpathogen - hypothetical protein Shew_3767 3 None None None 127513052 Common - protein of unknown function DUF195 Shew_2124 137 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 127511390 Common - hypothetical protein Shew_0456 5 None None None 127511656 Nonpathogen - hypothetical protein Shew_0722 1 None None None 127512964 Common - riboflavin synthase subunit alpha Shew_2036 208 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 127514051 Common - penicillin-binding protein 1B Shew_3123 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 127514116 Common - aromatic amino acid permease Shew_3188 32 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 127514658 Common - Sua5/YciO/YrdC/YwlC family protein Shew_3730 242 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 127511445 Common - type I secretion membrane fusion protein, HlyD family Shew_0511 131 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 127512664 Common - TonB-dependent receptor Shew_1735 113 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 127514379 Common - Polypeptide-transport-associated domain protein, FtsQ-type Shew_3451 79 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 127513192 Common - protein of unknown function DUF1097 Shew_2264 13 None None None 127511137 Common - acetylglutamate kinase Shew_0203 215 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 127514427 Common - bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase Shew_3499 207 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 127514092 Common - ABC transporter-related protein Shew_3164 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 127511332 Common - MSHA pilin protein MshC Shew_0398 5 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 127513184 Common trpA tryptophan synthase subunit alpha Shew_2256 211 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 127513410 Common - DNA polymerase II Shew_2482 65 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 127512071 Common - twitching motility protein Shew_1138 212 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 127514725 Common - efflux transporter, RND family, MFP subunit Shew_3797 158 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 127514705 Common - hypothetical protein Shew_3777 1 None None None 127512619 Nonpathogen - hypothetical protein Shew_1690 1 None None None 127510966 Common - efflux transporter, RND family, MFP subunit Shew_0031 158 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 127512712 Common - hypothetical protein Shew_1784 11 COG4129 COG4129, Predicted membrane protein Function unknown 127511580 Common - SAF domain protein Shew_0646 46 COG3745 CpaB, Flp pilus assembly protein CpaB Intracellular trafficking and secretion 127511410 Common - protein of unknown function DUF88 Shew_0476 73 COG1432 COG1432, Uncharacterized conserved protein Function unknown 127514077 Common - lipoprotein, putative Shew_3149 8 None None None 127514126 Common - glycine cleavage T protein (aminomethyl transferase) Shew_3198 118 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 127514631 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Shew_3703 167 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 127514070 Common - hypoxanthine phosphoribosyltransferase Shew_3142 154 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 127511998 Common trmD tRNA (guanine-N(1)-)-methyltransferase Shew_1065 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 127513301 Common - DSBA oxidoreductase Shew_2373 65 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 127514099 Common - prolipoprotein diacylglyceryl transferase Shew_3171 199 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 127513199 Nonpathogen - hypothetical protein Shew_2271 1 None None None 127514510 Common - hypothetical protein Shew_3582 4 None None None 127514449 Common - tryptophan halogenase Shew_3521 106 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 127512495 Common - ATP-dependent Clp protease, ATP-binding subunit clpA Shew_1566 220 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 127511011 Common - GCN5-related N-acetyltransferase Shew_0077 115 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 127513537 Common - inner-membrane translocator Shew_2609 148 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 127512470 Common - Carboxylesterase Shew_1541 108 COG0627 COG0627, Predicted esterase General function prediction only 127511434 Common - hypothetical protein Shew_0500 3 None None None 127512608 Common - transcriptional regulator, TetR family Shew_1679 98 COG1309 AcrR, Transcriptional regulator Transcription 127511482 Common - protein of unknown function UPF0227 Shew_0548 49 COG3150 COG3150, Predicted esterase General function prediction only 127512917 Common - hypothetical protein Shew_1989 22 COG3198 COG3198, Uncharacterized protein conserved in bacteria Function unknown 127513789 Common - aminoglycoside phosphotransferase Shew_2861 61 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 127513162 Common - conserved hypothetical protein 103 Shew_2234 120 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 127512572 Common - hypothetical protein Shew_1643 2 None None None 127513343 Common - major facilitator superfamily MFS_1 Shew_2415 83 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 127511455 Common metL bifunctional aspartate kinase II/homoserine dehydrogenase II Shew_0521 235 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 127512297 Common fliF flagellar MS-ring protein Shew_1366 125 COG1766 FliF, Flagellar biosynthesis/type III secretory pathway lipoprotein Cell motility and secretion / Intracellular trafficking and secretion 127513265 Common tgt queuine tRNA-ribosyltransferase Shew_2337 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 127512325 Common - hypothetical protein Shew_1394 1 None None None 127511033 Common - pseudouridine synthase Rlu family protein, TIGR01621 Shew_0099 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 127514617 Common - hypothetical protein Shew_3689 1 None None None 127512464 Common - fumarylacetoacetate (FAA) hydrolase Shew_1535 178 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 127512656 Common - hypothetical protein Shew_1727 7 None None None 127512337 Common - polysaccharide biosynthesis protein Shew_1406 12 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 127512033 Common - lipoprotein signal peptidase Shew_1100 204 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 127511507 Common sspA stringent starvation protein A Shew_0573 104 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 127514200 Common - Aldose 1-epimerase Shew_3272 89 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 127512739 Common - protein of unknown function DUF1379 Shew_1811 17 None None None 127511245 Common - type I secretion membrane fusion protein, HlyD family Shew_0311 122 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 127512228 Common xseA exodeoxyribonuclease VII large subunit Shew_1296 205 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 127511315 Common rpmE 50S ribosomal protein L31 Shew_0381 202 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 127512126 Common - glutathione-dependent formaldehyde-activating, GFA Shew_1194 58 COG3791 COG3791, Uncharacterized conserved protein Function unknown 127511745 Common - peptide chain release factor 2 Shew_0811 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 127513263 Common secD preprotein translocase subunit SecD Shew_2335 214 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 127512868 Common ansA cytoplasmic asparaginase I Shew_1940 137 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 127514227 Common - BolA family protein Shew_3299 68 COG5007 COG5007, Predicted transcriptional regulator, BolA superfamily Transcription 127514581 Nonpathogen - hypothetical protein Shew_3653 1 None None None 127514727 Nonpathogen - hypothetical protein Shew_3799 2 None None None 127511601 Common - phosphoadenosine phosphosulfate reductase Shew_0667 152 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 127513487 Common - malate synthase Shew_2559 55 None None None 127514763 Common - transposase, IS4 family protein Shew_3838 37 COG3039 COG3039, Transposase and inactivated derivatives, IS5 family DNA replication, recombination, and repair 127511460 Nonpathogen - hypothetical protein Shew_0526 1 None None None 127512341 Common - glycosyl transferase, group 1 Shew_1410 155 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 127513892 Common - beta-lactamase Shew_2964 75 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 127511078 Common - elongation factor Tu Shew_0144 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 127511274 Common - Ppx/GppA phosphatase Shew_0340 180 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 127513084 Common - Lysine exporter protein (LYSE/YGGA) Shew_2156 94 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 127512102 Common - glycogen/starch/alpha-glucan phosphorylase Shew_1170 133 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 127513426 Common - extracellular solute-binding protein, family 5 Shew_2498 209 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 127511472 Common - phage shock protein C, PspC Shew_0538 1 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 127514058 Common - Glutamate--tRNA ligase Shew_3130 245 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 127511494 Common - hypothetical protein Shew_0560 4 None None None 127513268 Common - Redoxin domain protein Shew_2340 76 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 127511095 Common rplB 50S ribosomal protein L2 Shew_0161 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 127512502 Common metG methionyl-tRNA synthetase Shew_1573 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 127512956 Common - thioredoxin reductase Shew_2028 248 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 127513383 Common - peptidase M23B Shew_2455 188 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 127513539 Common - ABC transporter-related protein Shew_2611 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 127512234 Common - cytochrome bd ubiquinol oxidase, subunit I Shew_1302 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 127511063 Common nudE ADP-ribose diphosphatase NudE Shew_0129 128 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 127513662 Common - 4-carboxymuconolactone decarboxylase Shew_2734 75 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 127512527 Common - hypothetical protein Shew_1598 58 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 127514467 Common - hypothetical protein Shew_3539 1 None None None 127513296 Common - Exonuclease, RNase T and DNA polymerase III Shew_2368 77 COG2176 PolC, DNA polymerase III, alpha subunit (gram-positive type) DNA replication, recombination, and repair 127511805 Common obgE GTPase ObgE Shew_0871 234 COG0536 Obg, Predicted GTPase General function prediction only 127512313 Common - Cobyrinic acid a,c-diamide synthase Shew_1382 159 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 127512086 Common - protein of unknown function UPF0126 Shew_1154 131 COG2860 COG2860, Predicted membrane protein Function unknown 127511721 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Shew_0787 230 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 127514322 Common - MscS Mechanosensitive ion channel Shew_3394 168 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 127513584 Common - 4'-phosphopantetheinyl transferase Shew_2656 39 COG2091 Sfp, Phosphopantetheinyl transferase Coenzyme metabolism 127513928 Common - diguanylate cyclase Shew_3000 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127513247 Common - serine O-acetyltransferase Shew_2319 202 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 127511545 Nonpathogen - hypothetical protein Shew_0611 1 None None None 127513917 Common - lipolytic enzyme, G-D-S-L family Shew_2989 102 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 127513910 Common - glucose-methanol-choline oxidoreductase Shew_2982 78 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 127512683 Common - hydrogenase expression/synthesis, HypA Shew_1755 49 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 127511209 Common - tetraheme cytochrome c, putative Shew_0275 3 None None None 127511569 Nonpathogen - hypothetical protein Shew_0635 1 None None None 127511668 Common - Fe-S metabolism associated SufE Shew_0734 93 COG2166 COG2166, SufE protein probably involved in Fe-S center assembly General function prediction only 127513882 Common - methyl-accepting chemotaxis sensory transducer Shew_2954 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127512468 Common - transcriptional regulator, LysR family Shew_1539 180 COG0583 LysR, Transcriptional regulator Transcription 127511267 Common - fumarate reductase respiratory complex, transmembrane subunit Shew_0333 10 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 127513901 Common - Endothelin-converting enzyme 1 Shew_2973 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 127511562 Common - (Glutamate--ammonia-ligase) adenylyltransferase Shew_0628 119 COG1391 GlnE, Glutamine synthetase adenylyltransferase Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms 127512724 Common - Mammalian cell entry related domain protein Shew_1796 56 COG3008 PqiB, Paraquat-inducible protein B General function prediction only 127514185 Common - copper-resistance protein, CopA family Shew_3257 121 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 127512510 Common - type IV pilus assembly PilZ Shew_1581 32 COG3215 PilZ, Tfp pilus assembly protein PilZ Cell motility and secretion / Intracellular trafficking and secretion 127511007 Nonpathogen - hypothetical protein Shew_0072 1 None None None 127511479 Common - ADP-ribose diphosphatase Shew_0545 157 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 127512076 Common - Holliday junction resolvase-like protein Shew_1143 178 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 127511188 Common - hypothetical protein Shew_0254 2 None None None 127513119 Common - hypothetical protein Shew_2191 11 None None None 127513454 Common - cytochrome C family protein Shew_2526 40 None None None 127510947 Nonpathogen - hypothetical protein Shew_0012 1 None None None 127512354 Common - Adenylyl-sulfate kinase Shew_1425 146 COG0529 CysC, Adenylylsulfate kinase and related kinases Inorganic ion transport and metabolism 127513556 Common - putative membrane-associated zinc metalloprotease Shew_2628 210 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 127511570 Nonpathogen - hypothetical protein Shew_0636 1 None None None 127514072 Common - UDP-N-acetylmuramate Shew_3144 209 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 127511724 Common - hypothetical protein Shew_0790 14 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 127511093 Common rplD 50S ribosomal protein L4 Shew_0159 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 127511108 Common rplR 50S ribosomal protein L18 Shew_0174 182 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 127513594 Common - omega-3 polyunsaturated fatty acid synthase PfaB Shew_2666 22 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 127511260 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Shew_0326 62 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 127511148 Common - 3-dehydroquinate synthase Shew_0214 207 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 127514128 Common - multi-sensor hybrid histidine kinase Shew_3200 224 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127511762 Common - transcriptional regulator, LysR family Shew_0828 192 COG0583 LysR, Transcriptional regulator Transcription 127510985 Common - DNA polymerase III subunit epsilon Shew_0050 108 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 127511256 Common - diaminopimelate decarboxylase Shew_0322 218 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 127514271 Common - integral membrane sensor signal transduction histidine kinase Shew_3343 134 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 127513895 Common - TonB-dependent receptor Shew_2967 106 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 127512989 Common - Radical SAM domain protein Shew_2061 173 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 127511600 Common - sulfite reductase (NADPH) hemoprotein, beta-component Shew_0666 151 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 127513670 Common - peptidase M1, membrane alanine aminopeptidase Shew_2742 160 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 127514634 Common - 3-deoxy-D-manno-octulosonic-acid kinase Shew_3706 20 COG0478 COG0478, RIO-like serine/threonine protein kinase fused to N-terminal HTH domain Signal transduction mechanisms 127511250 Common - protein of unknown function DUF513, hemX Shew_0316 55 COG2959 HemX, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 127511582 Common - hypothetical protein Shew_0648 2 None None None 127511486 Common - BFD domain protein (2Fe-2S)-binding domain protein Shew_0552 37 COG2906 Bfd, Bacterioferritin-associated ferredoxin Inorganic ion transport and metabolism 127513770 Common - peptidase M48, Ste24p Shew_2842 130 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 127511732 Nonpathogen - hypothetical protein Shew_0798 1 None None None 127514423 Common - hypothetical protein Shew_3495 6 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 127513802 Common - protein of unknown function DUF539 Shew_2874 17 COG2991 COG2991, Uncharacterized protein conserved in bacteria Function unknown 127511377 Common - Formate--tetrahydrofolate ligase Shew_0443 89 COG2759 MIS1, Formyltetrahydrofolate synthetase Nucleotide transport and metabolism 127511126 Common - TPR repeat-containing protein Shew_0192 54 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 127512252 Common - Methyltransferase type 12 Shew_1321 24 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 127511127 Common - cytochrome c-type biogenesis protein CcmF Shew_0193 134 COG1138 CcmF, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 127514438 Common - phospholipid/glycerol acyltransferase Shew_3510 82 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 127511196 Common - protein of unknown function UPF0061 Shew_0262 110 COG0397 COG0397, Uncharacterized conserved protein Function unknown 127512161 Common - hypothetical protein Shew_1229 38 COG4764 COG4764, Uncharacterized protein conserved in bacteria Function unknown 127513585 Common - hypothetical protein Shew_2657 3 None None None 127512025 Common - amino acid carrier protein Shew_1092 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 127512610 Common - diguanylate cyclase with PAS/PAC sensor Shew_1681 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127514318 Common - uridine phosphorylase Shew_3390 96 COG2820 Udp, Uridine phosphorylase Nucleotide transport and metabolism 127512489 Common trmU tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Shew_1560 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 127511404 Common - MATE efflux family protein Shew_0470 170 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 127514598 Common - metal dependent phosphohydrolase Shew_3670 124 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 127513261 Common - hypothetical protein Shew_2333 22 None None None 127512596 Common - acetyl-CoA acetyltransferase Shew_1667 185 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 127513276 Common - two component transcriptional regulator, winged helix family Shew_2348 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127513762 Common - ATP-dependent metalloprotease FtsH Shew_2834 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 127514406 Common - N-acetylglutamate synthase Shew_3478 208 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 127513142 Common - integration host factor, alpha subunit Shew_2214 209 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 127513679 Common rdgC recombination associated protein Shew_2751 53 COG2974 RdgC, DNA recombination-dependent growth factor C DNA replication, recombination, and repair 127514339 Common zntR zinc-responsive transcriptional regulator Shew_3411 147 COG0789 SoxR, Predicted transcriptional regulators Transcription 127514735 Common - peptidase M23B Shew_3807 198 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 127512045 Common - TonB-dependent receptor Shew_1112 24 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 127513596 Common - 2-nitropropane dioxygenase, NPD Shew_2668 22 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 127511519 Common - cAMP-regulatory protein Shew_0585 166 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 127512122 Common - Riboflavin synthase Shew_1190 230 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 127514770 Common - F0F1 ATP synthase subunit beta Shew_3845 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 127512714 Common - protein of unknown function DUF107 Shew_1786 61 COG1030 NfeD, Membrane-bound serine protease (ClpP class) Posttranslational modification, protein turnover, chaperones 127511111 Common rplO 50S ribosomal protein L15 Shew_0177 186 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 127512093 Common - NADH dehydrogenase Shew_1161 199 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 127511141 Common - penicillin-binding protein, 1A family Shew_0207 200 COG5009 MrcA, Membrane carboxypeptidase/penicillin-binding protein Cell envelope biogenesis, outer membrane 127512153 Common - sodium ion-translocating decarboxylase, beta subunit Shew_1221 56 COG1883 OadB, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit Energy production and conversion 127513468 Common - NIPSNAP family containing protein Shew_2540 18 None None None 127512909 Common - transcriptional regulator, AraC family Shew_1981 122 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 127514488 Common - signal transduction histidine kinase, nitrogen specific, NtrB Shew_3560 219 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 127514316 Common - protein of unknown function DUF107 Shew_3388 7 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 127514415 Common pyrE orotate phosphoribosyltransferase Shew_3487 139 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 127512415 Common - hypothetical protein Shew_1486 23 None None None 127514450 Common - hypothetical protein Shew_3522 6 None None None 127512291 Common - hypothetical protein Shew_1360 1 None None None 127511761 Common - peptidyl-prolyl cis-trans isomerase, cyclophilin type Shew_0827 197 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 127511408 Common - hypothetical protein Shew_0474 6 None None None 127511233 Common - transcriptional regulator, TetR family Shew_0299 119 COG1309 AcrR, Transcriptional regulator Transcription 127513347 Common - phosphohistidine phosphatase, SixA Shew_2419 61 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 127513302 Common - NAD-dependent epimerase/dehydratase Shew_2374 48 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 127512945 Common - DsrH like protein Shew_2017 1 COG2168 DsrH, Uncharacterized conserved protein involved in oxidation of intracellular sulfur Inorganic ion transport and metabolism 127512799 Common - DNA polymerase III, epsilon subunit Shew_1871 192 COG2176 PolC, DNA polymerase III, alpha subunit (gram-positive type) DNA replication, recombination, and repair 127513782 Common - hypothetical protein Shew_2854 2 None None None 127513799 Common - DNA polymerase IV Shew_2871 184 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 127511511 Common - putative signal transduction protein Shew_0577 4 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 127512155 Common - hypothetical protein Shew_1223 4 None None None 127514304 Common - twin-arginine translocation protein, TatA/E family subunit Shew_3376 52 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 127513615 Common - hypothetical protein Shew_2687 60 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 127512760 Common - hypothetical protein Shew_1832 71 COG2718 COG2718, Uncharacterized conserved protein Function unknown 127513255 Common - hypothetical protein Shew_2327 12 None None None 127511392 Common - PhoH family protein Shew_0458 198 COG1875 COG1875, Predicted ATPase related to phosphate starvation-inducible protein PhoH Signal transduction mechanisms 127513179 Common - anthranilate synthase component I Shew_2251 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 127512568 Common - tetraacyldisaccharide 4'-kinase Shew_1639 129 COG1663 LpxK, Tetraacyldisaccharide-1-P 4'-kinase Cell envelope biogenesis, outer membrane 127512065 Common - non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family Shew_1132 237 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 127514475 Common - hypothetical protein Shew_3547 14 None None None 127513288 Common - D-amino-acid dehydrogenase Shew_2360 130 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 127512462 Common - acetate--CoA ligase Shew_1533 213 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 127512873 Common nrdB ribonucleotide-diphosphate reductase subunit beta Shew_1945 154 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 127514546 Common - general secretory pathway protein E Shew_3618 215 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 127512211 Common - protein of unknown function DUF980 Shew_1279 58 COG3228 COG3228, Uncharacterized protein conserved in bacteria Function unknown 127514028 Common - UspA domain protein Shew_3100 75 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 127511350 Common - peptidase U62, modulator of DNA gyrase Shew_0416 157 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 127514108 Common - pseudouridine synthase Shew_3180 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 127513134 Common - two component transcriptional regulator, winged helix family Shew_2206 215 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127511041 Common - MATE efflux family protein Shew_0107 94 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 127511643 Common - catalase/peroxidase HPI Shew_0709 98 COG0376 KatG, Catalase (peroxidase I) Inorganic ion transport and metabolism 127511679 Common - hypothetical protein Shew_0745 1 None None None 127511421 Common - redox-active disulfide protein 2 Shew_0487 67 COG3634 AhpF, Alkyl hydroperoxide reductase, large subunit Posttranslational modification, protein turnover, chaperones 127514497 Common - protein of unknown function, Spy-related Shew_3569 23 COG3678 CpxP, P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism 127512693 Common - hydrogenase (NiFe) small subunit HydA Shew_1765 77 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 127513816 Common - hypothetical protein Shew_2888 21 None None None 127513366 Common - protein of unknown function DUF541 Shew_2438 28 COG2859 COG2859, Uncharacterized protein conserved in bacteria Function unknown 127514643 Common - GTPase EngB Shew_3715 179 COG0218 COG0218, Predicted GTPase General function prediction only 127512822 Common - hypothetical protein Shew_1894 12 None None None 127512050 Common - N-acetylglucosamine-6-phosphate deacetylase Shew_1117 118 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 127514002 Common - pilin, putative Shew_3074 6 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 127514208 Nonpathogen - hypothetical protein Shew_3280 1 None None None 127513016 Common - transcriptional regulator, LysR family Shew_2088 154 COG0583 LysR, Transcriptional regulator Transcription 127514350 Common - uroporphyrinogen decarboxylase Shew_3422 182 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 127514364 Nonpathogen - methylation site containing protein Shew_3436 2 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 127511991 Common - holo-acyl-carrier-protein synthase Shew_1058 94 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 127512635 Common - glutathione-dependent formaldehyde-activating, GFA Shew_1706 52 COG3791 COG3791, Uncharacterized conserved protein Function unknown 127513076 Common - hypothetical protein Shew_2148 43 COG3304 COG3304, Predicted membrane protein Function unknown 127511576 Common - type II secretion system protein Shew_0642 91 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion 127513736 Common - type IV pilus assembly PilZ Shew_2808 7 None None None 127513640 Common - peptidase S15 Shew_2712 61 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 127512781 Common - hypothetical protein Shew_1853 5 None None None 127511375 Common - MaoC domain protein dehydratase Shew_0441 25 COG2030 MaoC, Acyl dehydratase Lipid metabolism 127511100 Common - 50S ribosomal protein L29 Shew_0166 143 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 127511689 Common - fructose-1,6-bisphosphate aldolase Shew_0755 176 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 127513714 Common - Sterol-binding domain protein Shew_2786 33 COG3154 COG3154, Putative lipid carrier protein Lipid metabolism 127514715 Common mogA molybdenum cofactor biosynthesis protein Shew_3787 190 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 127512861 Common - Endonuclease/exonuclease/phosphatase Shew_1933 33 COG3021 COG3021, Uncharacterized protein conserved in bacteria Function unknown 127512218 Common - protein of unknown function DUF21 Shew_1286 218 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 127513112 Common - septum site-determining protein MinC Shew_2184 111 COG0850 MinC, Septum formation inhibitor Cell division and chromosome partitioning 127512924 Common - hypothetical protein Shew_1996 6 None None None 127512756 Common - Peptidoglycan-binding domain 1 protein Shew_1828 74 COG2989 COG2989, Uncharacterized protein conserved in bacteria Function unknown 127513231 Common - Colicin V production protein Shew_2303 109 COG1286 CvpA, Uncharacterized membrane protein, required for colicin V production General function prediction only 127511672 Common - NTPase Shew_0738 34 COG1986 COG1986, Uncharacterized conserved protein Function unknown 127514481 Common - GTP-binding protein TypA Shew_3553 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 127513856 Common - protein of unknown function DUF1451 Shew_2928 19 None None None 127512172 Common - hypothetical protein Shew_1240 13 None None None 127513432 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Shew_2504 167 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 127512366 Common - transcriptional regulator, TyrR Shew_1437 168 COG3283 TyrR, Transcriptional regulator of aromatic amino acids metabolism Transcription / Amino acid transport and metabolism 127511983 Common - sigma E regulatory protein, MucB/RseB Shew_1050 46 COG3026 RseB, Negative regulator of sigma E activity Signal transduction mechanisms 127511594 Common - hypothetical protein Shew_0660 1 None None None 127512134 Common - (p)ppGpp synthetase I, SpoT/RelA Shew_1202 205 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 127511176 Common - molydopterin dinucleotide-binding region Shew_0242 183 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 127512442 Common - phosphoribosylaminoimidazole synthetase Shew_1513 232 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 127512555 Common - beta-hexosaminidase Shew_1626 177 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 127514791 Common - 60 kDa inner membrane insertion protein Shew_3866 213 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 127511622 Common - dihydropteridine reductase Shew_0688 70 COG0778 NfnB, Nitroreductase Energy production and conversion 127512208 Common - isocitrate lyase Shew_1276 128 COG2224 AceA, Isocitrate lyase Energy production and conversion 127512196 Common - UvrD/REP helicase Shew_1264 228 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 127514523 Common - protein of unknown function DUF1332 Shew_3595 30 COG4103 COG4103, Uncharacterized protein conserved in bacteria Function unknown 127513574 Common - hypothetical protein Shew_2646 4 None None None 127513354 Common fadI 3-ketoacyl-CoA thiolase Shew_2426 176 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 127512979 Common - acyl-CoA dehydrogenase Shew_2051 149 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 127511713 Common - aspartate kinase III Shew_0779 233 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 127513172 Common - TonB-dependent receptor Shew_2244 111 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 127514244 Common - magnesium transporter Shew_3316 170 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 127514667 Common trkA potassium transporter peripheral membrane component Shew_3739 143 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 127514359 Common aceE pyruvate dehydrogenase subunit E1 Shew_3431 152 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 127511948 Common - Cl- channel, voltage-gated family protein Shew_1015 156 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 127513037 Common - sodium/hydrogen exchanger Shew_2109 125 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 127512711 Common - secretion protein HlyD family protein Shew_1783 84 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 127512769 Common - peptidase M48, Ste24p Shew_1841 123 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 127510973 Common - Excinuclease ABC, C subunit domain protein Shew_0038 72 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 127511902 Common - FAD dependent oxidoreductase Shew_0969 120 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 127511273 Common - ATP-dependent RNA helicase RhlB Shew_0339 238 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 127513498 Common - acyl-CoA dehydrogenase domain protein Shew_2570 172 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 127511950 Common - iron-sulfur cluster assembly accessory protein Shew_1017 166 COG0316 IscA, Uncharacterized conserved protein Function unknown 127513870 Common - lipoyl synthase Shew_2942 190 COG0320 LipA, Lipoate synthase Coenzyme metabolism 127513879 Common - putative lipoprotein Shew_2951 125 COG4105 ComL, DNA uptake lipoprotein General function prediction only 127512899 Common - ApbE family lipoprotein Shew_1971 125 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 127513361 Common - RNA polymerase sigma factor Shew_2433 139 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 127511682 Common - acetyltransferase, GNAT family Shew_0748 4 None None None 127511162 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Shew_0228 209 COG0313 COG0313, Predicted methyltransferases General function prediction only 127513728 Common - DEAD/DEAH box helicase domain protein Shew_2800 239 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 127514043 Common - sodium:dicarboxylate symporter Shew_3115 162 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 127511467 Common - excinuclease ABC, A subunit Shew_0533 235 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 127511325 Common - Tetratricopeptide TPR_2 repeat protein Shew_0391 32 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 127512547 Common - hypothetical protein Shew_1618 43 COG2996 COG2996, Uncharacterized protein conserved in bacteria Function unknown 127514256 Common - Ig domain protein, group 2 domain protein Shew_3328 11 COG5492 COG5492, Bacterial surface proteins containing Ig-like domains Cell motility and secretion 127512972 Common - ecotin precursor Shew_2044 23 COG4574 Eco, Serine protease inhibitor ecotin General function prediction only 127513516 Common - lipoprotein, putative Shew_2588 8 None None None 127511506 Common - cytochrome c1 Shew_0572 84 COG2857 CYT1, Cytochrome c1 Energy production and conversion 127511929 Common - RNA polymerase, sigma 70 subunit, RpoD family Shew_0996 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 127512306 Common - flagellar biosynthesis protein, FliO Shew_1375 7 COG3190 FliO, Flagellar biogenesis protein Cell motility and secretion 127512943 Common - DsrE family protein Shew_2015 42 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 127512542 Common rrmA 23S rRNA methyltransferase A Shew_1613 65 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 127512620 Nonpathogen - hypothetical protein Shew_1691 1 None None None 127513941 Common - sodium/proline symporter Shew_3013 172 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 127514260 Common - protein of unknown function DUF461 Shew_3332 72 COG2847 COG2847, Uncharacterized protein conserved in bacteria Function unknown 127514023 Nonpathogen - hypothetical protein Shew_3095 1 None None None 127511898 Common - methylmalonate-semialdehyde dehydrogenase Shew_0965 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 127510938 Common - DNA replication and repair protein RecF Shew_0003 169 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 127513046 Common - hypothetical protein Shew_2118 1 None None None 127514425 Common - Guanylate kinase Shew_3497 214 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 127514606 Common - hypothetical protein Shew_3678 6 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 127514793 Common - ribonuclease P protein component Shew_3868 73 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 127511980 Common - L-aspartate oxidase Shew_1047 226 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 127513983 Common - CMP/dCMP deaminase, zinc-binding Shew_3055 77 COG2131 ComEB, Deoxycytidylate deaminase Nucleotide transport and metabolism 127514130 Common - protein of unknown function DUF214 Shew_3202 42 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 127514195 Common - sodium/hydrogen exchanger Shew_3267 117 COG4651 RosB, Kef-type K+ transport system, predicted NAD-binding component Inorganic ion transport and metabolism 127512802 Common - major facilitator superfamily MFS_1 Shew_1874 38 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 127513041 Common - hypothetical protein Shew_2113 53 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 127513245 Common - cysteine desulfurase IscS Shew_2317 240 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 127511300 Common - ubiquinol oxidase, subunit II Shew_0366 105 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 127513227 Common - DNA topoisomerase III Shew_2299 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 127512277 Common flgC flagellar basal body rod protein FlgC Shew_1346 126 COG1558 FlgC, Flagellar basal body rod protein Cell motility and secretion 127513704 Common - cobalamin synthesis protein, P47K Shew_2776 127 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 127513864 Common - rod shape-determining protein RodA Shew_2936 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 127511309 Common - ATP-dependent protease peptidase subunit Shew_0375 149 COG5405 HslV, ATP-dependent protease HslVU (ClpYQ), peptidase subunit Posttranslational modification, protein turnover, chaperones 127513291 Common - proline racemase Shew_2363 47 COG3938 COG3938, Proline racemase Amino acid transport and metabolism 127514306 Common - Sec-independent protein translocase, TatC subunit Shew_3378 205 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 127512182 Nonpathogen - hypothetical protein Shew_1250 1 None None None 127513035 Common - glutamine amidotransferase, class-II Shew_2107 74 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 127513958 Common - hypothetical protein Shew_3030 6 None None None 127512816 Common - TonB-dependent receptor, plug Shew_1888 26 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 127511025 Common - molybdopterin biosynthesis MoaE Shew_0091 160 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 127513323 Common - hypothetical protein Shew_2395 4 None None None 127513213 Common - UDP-glucose 4-epimerase Shew_2285 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 127512953 Common - leucine-responsive transcriptional regulator Shew_2025 158 COG1522 Lrp, Transcriptional regulators Transcription 127512902 Common - hypothetical protein Shew_1974 63 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 127512434 Common - hypothetical protein Shew_1505 10 COG4399 COG4399, Uncharacterized protein conserved in bacteria Function unknown 127511828 Common - integral membrane sensor signal transduction histidine kinase Shew_0895 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127511968 Common - transcriptional regulator, LysR family Shew_1035 155 COG0583 LysR, Transcriptional regulator Transcription 127513304 Common - hypothetical protein Shew_2376 8 None None None 127514249 Common - protein of unknown function DUF752 Shew_3321 84 COG4121 COG4121, Uncharacterized conserved protein Function unknown 127513333 Common - hypothetical protein Shew_2405 12 None None None 127514060 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Shew_3132 195 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 127512189 Common - DNA repair protein RadC Shew_1257 179 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 127513203 Common - Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B Shew_2275 86 COG3384 COG3384, Uncharacterized conserved protein Function unknown 127511694 Common - response regulator receiver protein Shew_0760 1 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127513968 Nonpathogen - hypothetical protein Shew_3040 1 None None None 127511931 Common - GatB/Yqey domain protein Shew_0998 153 COG1610 COG1610, Uncharacterized conserved protein Function unknown 127512116 Common - hypothetical protein Shew_1184 11 None None None 127514503 Nonpathogen - hypothetical protein Shew_3575 1 None None None 127512871 Common - hypothetical protein Shew_1943 5 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 127512660 Common - histidine triad (HIT) protein Shew_1731 229 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 127511779 Common - isochorismatase hydrolase Shew_0845 89 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 127512836 Nonpathogen - hypothetical protein Shew_1908 3 None None None 127512110 Common - acriflavin resistance protein Shew_1178 178 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 127511973 Common - protein of unknown function DUF81 Shew_1040 81 COG0730 COG0730, Predicted permeases General function prediction only 127513173 Common - hypothetical protein Shew_2245 3 None None None 127510995 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Shew_0060 168 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 127512915 Common - Cbb3-type cytochrome oxidase component Shew_1987 17 COG4736 CcoQ, Cbb3-type cytochrome oxidase, subunit 3 Posttranslational modification, protein turnover, chaperones 127512804 Common - alpha-glucosidase Shew_1876 18 None None None 127512857 Common - methyl-accepting chemotaxis sensory transducer Shew_1929 155 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127514452 Common - Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ Shew_3524 27 COG4706 COG4706, Predicted 3-hydroxylacyl-(acyl carrier protein) dehydratase Lipid metabolism 127513597 Common - Penicillin amidase Shew_2669 73 COG2366 COG2366, Protein related to penicillin acylase General function prediction only 127512911 Common - response regulator receiver modulated metal dependent phosphohydrolase Shew_1983 125 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 127512143 Common - protein-L-isoaspartate O-methyltransferase Shew_1211 158 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 127513311 Common - putative transcriptional regulator, TetR family Shew_2383 21 COG3226 COG3226, Uncharacterized protein conserved in bacteria Function unknown 127511500 Common - RNA chaperone Hfq Shew_0566 127 COG1923 Hfq, Uncharacterized host factor I protein General function prediction only 127512703 Common - acetolactate synthase, small subunit Shew_1775 193 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 127511835 Common - (acyl-carrier-protein) S-malonyltransferase Shew_0902 30 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 127511710 Common - bifunctional deaminase-reductase domain protein Shew_0776 65 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 127511043 Common - response regulator receiver modulated CheB methylesterase Shew_0109 219 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 127513074 Common - hypothetical protein Shew_2146 2 None None None 127512762 Common - Superoxide dismutase Shew_1834 203 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 127512451 Common - Prolyl oligopeptidase Shew_1522 117 COG1505 COG1505, Serine proteases of the peptidase family S9A Amino acid transport and metabolism 127512474 Common - two component transcriptional regulator, LuxR family Shew_1545 198 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 127512397 Nonpathogen - hypothetical protein Shew_1468 1 None None None 127513214 Common - SSS sodium solute transporter superfamily Shew_2286 147 COG4146 COG4146, Predicted symporter General function prediction only 127514648 Common - coproporphyrinogen III oxidase Shew_3720 203 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 127513851 Common - tRNA-i(6)A37 thiotransferase enzyme MiaB Shew_2923 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 127511204 Common - hypothetical protein Shew_0270 4 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 127513931 Common fadE acyl-CoA dehydrogenase Shew_3003 149 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 127514534 Common - signal recognition particle-docking protein FtsY Shew_3606 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 127511864 Common - protein of unknown function DUF52 Shew_0931 66 COG1355 COG1355, Predicted dioxygenase General function prediction only 127514146 Common - Carbamoyl-phosphate synthase L chain, ATP-binding Shew_3218 233 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 127511574 Common - TPR repeat-containing protein Shew_0640 31 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 127514063 Common - L-lactate permease Shew_3135 103 COG1620 LldP, L-lactate permease Energy production and conversion 127513655 Common - hypothetical protein Shew_2727 37 COG5587 COG5587, Uncharacterized conserved protein Function unknown 127514049 Nonpathogen - FMN-binding domain protein Shew_3121 4 None None None 127513858 Common - Rare lipoprotein B Shew_2930 24 COG2980 RlpB, Rare lipoprotein B Cell envelope biogenesis, outer membrane 127512404 Common - hypothetical protein Shew_1475 8 COG2802 COG2802, Uncharacterized protein, similar to the N-terminal domain of Lon protease General function prediction only 127511134 Common - phosphoenolpyruvate carboxylase Shew_0200 120 COG2352 Ppc, Phosphoenolpyruvate carboxylase Energy production and conversion 127513106 Nonpathogen - hypothetical protein Shew_2178 2 None None None 127513627 Common - cyclic nucleotide-binding protein Shew_2699 26 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 127511821 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Shew_0887 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 127512774 Common - Redoxin domain protein Shew_1846 214 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 127514069 Common - ABC transporter-related protein Shew_3141 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 127513691 Common - dienelactone hydrolase Shew_2763 33 COG3571 COG3571, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 127511013 Common - TAP domain protein Shew_0079 32 None None None 127514119 Common - hypothetical protein Shew_3191 10 None None None 127512469 Common - Alcohol dehydrogenase, zinc-binding domain protein Shew_1540 194 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 127511893 Common - protein of unknown function DUF368 Shew_0960 48 COG2035 COG2035, Predicted membrane protein Function unknown 127511417 Nonpathogen - hypothetical protein Shew_0483 4 None None None 127513090 Common cpdB bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein Shew_2162 117 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 127513406 Common - hypothetical protein Shew_2478 18 None None None 127513629 Common - hypothetical protein Shew_2701 9 None None None 127514269 Common - diguanylate cyclase with GAF sensor Shew_3341 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127512674 Common - GCN5-related N-acetyltransferase Shew_1745 51 COG0456 RimI, Acetyltransferases General function prediction only 127513993 Common - Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family Shew_3065 137 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 127513696 Common - flagellar motor protein PomA Shew_2768 88 COG1291 MotA, Flagellar motor component Cell motility and secretion 127513669 Common - Glutathione peroxidase Shew_2741 114 COG0386 BtuE, Glutathione peroxidase Posttranslational modification, protein turnover, chaperones 127512385 Common - phospholipase D/Transphosphatidylase Shew_1456 147 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 127514121 Common - Endonuclease/exonuclease/phosphatase Shew_3193 49 COG2374 COG2374, Predicted extracellular nuclease General function prediction only 127511906 Common - extracellular solute-binding protein, family 1 Shew_0973 129 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 127513312 Common - O-methyltransferase, family 2 Shew_2384 23 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 127511624 Common - Endonuclease/exonuclease/phosphatase Shew_0690 13 COG2374 COG2374, Predicted extracellular nuclease General function prediction only 127514234 Common - KpsF/GutQ family protein Shew_3306 175 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 127512537 Common - carbohydrate kinase, FGGY Shew_1608 181 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 127512529 Common - fatty acid/phospholipid synthesis protein Shew_1600 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 127513464 Common - putative thiol-disulphide oxidoreductase DCC Shew_2536 32 COG3011 COG3011, Uncharacterized protein conserved in bacteria Function unknown 127514573 Nonpathogen - hypothetical protein Shew_3645 1 None None None 127511334 Common - methylation site containing protein Shew_0400 15 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 127512887 Common - short chain dehydrogenase Shew_1959 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 127510964 Common - conserved hypothetical 3-methyladenine DNA glycosylase Shew_0029 48 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 127512966 Nonpathogen - hypothetical protein Shew_2038 1 None None None 127514012 Common - AMP-dependent synthetase and ligase Shew_3084 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127514163 Common - integral membrane sensor signal transduction histidine kinase Shew_3235 219 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 127514090 Common - hypothetical protein Shew_3162 3 None None None 127511630 Common - ribokinase Shew_0696 193 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 127512004 Common - hypothetical protein Shew_1071 1 COG3671 COG3671, Predicted membrane protein Function unknown 127514344 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Shew_3416 180 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 127510956 Common - protein of unknown function UPF0029 Shew_0021 132 COG1739 COG1739, Uncharacterized conserved protein Function unknown 127514014 Common - hypothetical protein Shew_3086 10 None None None 127514053 Common - diguanylate cyclase/phosphodiesterase Shew_3125 175 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 127514040 Common - flavocytochrome c Shew_3112 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 127514707 Common - transcriptional regulator, GntR family Shew_3779 116 COG1725 COG1725, Predicted transcriptional regulators Transcription 127512232 Common - Lytic transglycosylase, catalytic Shew_1300 106 COG4623 COG4623, Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein Cell envelope biogenesis, outer membrane 127512246 Common - hypothetical protein Shew_1315 19 None None None 127513190 Common - exonuclease III Shew_2262 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 127513321 Common - acetate kinase Shew_2393 162 COG0282 ackA, Acetate kinase Energy production and conversion 127513398 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Shew_2470 144 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 127514000 Common - cold-shock protein, DNA-binding Shew_3072 10 None None None 127513757 Common - protein of unknown function DUF150 Shew_2829 183 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 127513151 Common - YceI family protein Shew_2223 11 None None None 127513028 Common - DNA polymerase III, alpha subunit Shew_2100 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 127512497 Common - arginyl-tRNA-protein transferase Shew_1568 85 COG2935 COG2935, Putative arginyl-tRNA:protein arginylyltransferase Posttranslational modification, protein turnover, chaperones 127514335 Common - transcriptional regulator, LysR family Shew_3407 180 COG0583 LysR, Transcriptional regulator Transcription 127514294 Common - metal dependent phosphohydrolase Shew_3366 109 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 127513065 Common - Glutathione S-transferase, C-terminal domain Shew_2137 79 COG0435 ECM4, Predicted glutathione S-transferase Posttranslational modification, protein turnover, chaperones 127513182 Common - bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase Shew_2254 220 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 127513545 Common - potassium efflux system protein Shew_2617 218 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 127514009 Common - TonB-dependent receptor Shew_3081 90 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 127514613 Common - ABC transporter-related protein Shew_3685 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 127511224 Common ilvM acetolactate synthase 2 regulatory subunit Shew_0290 22 COG3978 COG3978, Acetolactate synthase (isozyme II), small (regulatory) subunit Function unknown 127511416 Common - hypothetical protein Shew_0482 22 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 127513824 Common - sodium:neurotransmitter symporter Shew_2896 88 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 127514689 Common - hypothetical protein Shew_3761 16 None None None 127511616 Common - permease of the major facilitator superfamily Shew_0682 2 COG1289 COG1289, Predicted membrane protein Function unknown 127513345 Common - N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase Shew_2417 219 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 127511669 Common - cysteine desulfurase, SufS subfamily Shew_0735 239 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 127514097 Common - WD-40 repeat protein Shew_3169 17 COG2319 COG2319, FOG: WD40 repeat General function prediction only 127511436 Common - hypothetical protein Shew_0502 3 COG1433 COG1433, Uncharacterized conserved protein Function unknown 127513197 Common - beta-lactamase domain protein Shew_2269 219 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 127511280 Common - cytochrome C biogenesis protein Shew_0346 72 COG3088 CcmH, Uncharacterized protein involved in biosynthesis of c-type cytochromes Posttranslational modification, protein turnover, chaperones 127512666 Common - nicotinamide mononucleotide transporter PnuC Shew_1737 55 COG3201 PnuC, Nicotinamide mononucleotide transporter Coenzyme metabolism 127513804 Common - Na(+)-translocating NADH-quinone reductase subunit F Shew_2876 157 COG2871 NqrF, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF Energy production and conversion 127513750 Common - polynucleotide phosphorylase/polyadenylase Shew_2822 240 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 127512267 Common - hypothetical protein Shew_1336 15 COG2604 COG2604, Uncharacterized protein conserved in bacteria Function unknown 127514079 Common - hypothetical protein Shew_3151 13 COG5373 COG5373, Predicted membrane protein Function unknown 127514519 Common - hypothetical protein Shew_3591 12 None None None 127513849 Common - Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family Shew_2921 133 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 162139869 Common - protein of unknown function DUF1414 Shew_1471 21 COG3082 COG3082, Uncharacterized protein conserved in bacteria Function unknown 127511480 Common - protein of unknown function DUF1249 Shew_0546 23 COG3151 COG3151, Uncharacterized protein conserved in bacteria Function unknown 127512068 Common - protein of unknown function YGGT Shew_1135 95 COG0762 COG0762, Predicted integral membrane protein Function unknown 127512570 Common - Mn2+-dependent serine/threonine protein kinase Shew_1641 11 COG3642 COG3642, Mn2+-dependent serine/threonine protein kinase Signal transduction mechanisms 127511559 Common - spermidine synthase Shew_0625 107 COG4262 COG4262, Predicted spermidine synthase with an N-terminal membrane domain General function prediction only 127513777 Common - Xanthine/uracil/vitamin C permease Shew_2849 134 COG2252 COG2252, Permeases General function prediction only 127512439 Common - peptidase M28 Shew_1510 53 COG2234 Iap, Predicted aminopeptidases General function prediction only 127513189 Common - YciI-like protein Shew_2261 72 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 127511806 Common - protein of unknown function DUF1212 Shew_0872 51 COG2966 COG2966, Uncharacterized conserved protein Function unknown 127514615 Common - molybdopterin-guanine dinucleotide biosynthesis protein B Shew_3687 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 127512654 Common - Curlin associated repeat protein Shew_1725 18 None None None 127513526 Common - hypothetical protein Shew_2598 6 None None None 127512323 Common - hypothetical protein Shew_1392 14 None None None 127511084 Common - ribosomal protein L7/L12 Shew_0150 213 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 127512087 Common - Threonine aldolase Shew_1155 105 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 127514408 Common - ribosomal protein L28 Shew_3480 163 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 127513540 Common - hypothetical protein Shew_2612 21 None None None 127513121 Common - peptidase M22, glycoprotease Shew_2193 191 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 127514753 Common - transposition protein Shew_3825 16 None None None 127512283 Common flgI flagellar basal body P-ring protein Shew_1352 105 COG1706 FlgI, Flagellar basal-body P-ring protein Cell motility and secretion 127514700 Common - thioesterase superfamily protein Shew_3772 70 COG0824 FcbC, Predicted thioesterase General function prediction only 127511923 Nonpathogen - hypothetical protein Shew_0990 1 None None None 127511076 Common - biotin--protein ligase Shew_0142 231 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 127513145 Common - methyl-accepting chemotaxis sensory transducer Shew_2217 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127512421 Common - MATE efflux family protein Shew_1492 119 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 127511364 Common - histone family protein DNA-binding protein Shew_0430 211 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 127511164 Common - hypothetical protein Shew_0230 7 COG2831 FhaC, Hemolysin activation/secretion protein Intracellular trafficking and secretion 127514386 Common - UDP-N-acetylmuramyl-tripeptide synthetase Shew_3458 211 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 127511527 Common - ABC transporter-related protein Shew_0593 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 127513120 Common - hypothetical protein Shew_2192 1 None None None 127514213 Common - protein of unknown function DUF481 Shew_3285 34 COG3137 COG3137, Putative salt-induced outer membrane protein Cell envelope biogenesis, outer membrane 127512109 Common - efflux transporter, RND family, MFP subunit Shew_1177 161 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 127511237 Common - hypothetical protein Shew_0303 29 COG4452 CreD, Inner membrane protein involved in colicin E2 resistance Defense mechanisms 127513059 Common - exodeoxyribonuclease V, alpha subunit Shew_2131 120 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 127511313 Common - primosomal protein N' Shew_0379 213 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 127514748 Nonpathogen - hypothetical protein Shew_3820 1 None None None 127514219 Common - Adenylosuccinate synthase Shew_3291 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 127511631 Common rihA ribonucleoside hydrolase 1 Shew_0697 88 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 127513473 Common - diguanylate cyclase Shew_2545 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127514397 Common - 3-isopropylmalate dehydratase, small subunit Shew_3469 210 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 127512882 Common rpsA 30S ribosomal protein S1 Shew_1954 216 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 127513236 Common - aspartate-semialdehyde dehydrogenase Shew_2308 236 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 127513224 Common - TonB-dependent receptor Shew_2296 41 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 127514550 Common hslO Hsp33-like chaperonin Shew_3622 136 COG1281 COG1281, Disulfide bond chaperones of the HSP33 family Posttranslational modification, protein turnover, chaperones 127514626 Nonpathogen - glycosyl transferase, family 8 Shew_3698 1 COG1442 RfaJ, Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases Cell envelope biogenesis, outer membrane 127512863 Common - protein of unknown function DUF885 Shew_1935 40 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 127513735 Common - DNA repair protein RadA Shew_2807 204 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 127511552 Common - protein of unknown function DUF47 Shew_0618 42 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 127513443 Common - protein of unknown function DUF1282 Shew_2515 24 None None None 127511856 Common valS valyl-tRNA synthetase Shew_0923 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 127512612 Common - protein of unknown function DUF1415 Shew_1683 30 COG3310 COG3310, Uncharacterized protein conserved in bacteria Function unknown 127513635 Common - Na(+)-translocating NADH-quinone reductase subunit C Shew_2707 46 COG2869 NqrC, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC Energy production and conversion 127514239 Common - RNA polymerase factor sigma-54 Shew_3311 145 COG1508 RpoN, DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog Transcription 127512359 Common - hypothetical protein Shew_1430 8 None None None 127511702 Common - methyltransferase small Shew_0768 78 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 127512488 Common - hypothetical protein Shew_1559 41 COG2915 COG2915, Uncharacterized protein involved in purine metabolism General function prediction only 127513657 Common - transcriptional regulator, TetR family Shew_2729 86 COG1309 AcrR, Transcriptional regulator Transcription 127514494 Common - efflux transporter, RND family, MFP subunit Shew_3566 110 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 127512060 Common - hypothetical protein Shew_1127 6 None None None 127511878 Common - protein of unknown function DUF1449 Shew_0945 13 None None None 127512894 Common - DTW domain containing protein Shew_1966 31 COG3148 COG3148, Uncharacterized conserved protein Function unknown 127512928 Common - glyceraldehyde-3-phosphate dehydrogenase Shew_2000 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 127514184 Common - copper resistance B precursor Shew_3256 43 COG3667 PcoB, Uncharacterized protein involved in copper resistance Inorganic ion transport and metabolism 127512080 Common - hypothetical protein Shew_1147 21 None None None 127514401 Common - response regulator receiver protein Shew_3473 2 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 127513563 Common rpsB 30S ribosomal protein S2 Shew_2635 218 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 127511520 Common - tetratricopeptide TPR_2 repeat protein Shew_0586 76 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 127511366 Common - hypothetical protein Shew_0432 6 None None None 127512335 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Shew_1404 167 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 127513637 Common - Na(+)-translocating NADH-quinone reductase subunit A Shew_2709 42 COG1726 NqrA, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA Energy production and conversion 127511009 Nonpathogen - hypothetical protein Shew_0075 1 None None None 127514779 Common - Cobyrinic acid a,c-diamide synthase Shew_3854 217 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 127514649 Common - adenosine deaminase Shew_3721 112 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 127514395 Common - hypothetical protein Shew_3467 2 None None None 127514402 Common - ATP-dependent DNA helicase RecQ Shew_3474 239 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 127511711 Common - DNA-binding response regulator in two-component regulatory system with ArcB or CpxA Shew_0777 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127513438 Common - Methylenetetrahydrofolate dehydrogenase (NADP(+)) Shew_2510 223 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 127513850 Common - hypothetical protein Shew_2922 1 None None None 127514044 Common - hypothetical protein Shew_3116 9 None None None 127513031 Common def peptide deformylase Shew_2103 215 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 127511186 Common - hypothetical protein Shew_0252 3 None None None 127512567 Common - lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA Shew_1638 247 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 127510949 Common - hypothetical protein Shew_0014 14 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 127514206 Common - replicative DNA helicase Shew_3278 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 127513242 Common hscB co-chaperone HscB Shew_2314 56 COG1076 DjlA, DnaJ-domain-containing proteins 1 Posttranslational modification, protein turnover, chaperones 127510981 Common - molybdenum cofactor synthesis domain protein Shew_0046 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 127514274 Common - hypothetical protein Shew_3346 19 COG4461 LprI, Uncharacterized protein conserved in bacteria, putative lipoprotein Function unknown 127513743 Common - deoxyribose-phosphate aldolase Shew_2815 138 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 127511952 Common - hypothetical protein Shew_1019 15 None None None 127511764 Common - LrgB family protein Shew_0830 67 COG1346 LrgB, Putative effector of murein hydrolase Cell envelope biogenesis, outer membrane 127514418 Common - transcriptional regulator, XRE family Shew_3490 54 COG1396 HipB, Predicted transcriptional regulators Transcription 127513075 Common - hypothetical protein Shew_2147 14 COG2515 Acd, 1-aminocyclopropane-1-carboxylate deaminase Amino acid transport and metabolism 127514174 Common - hypothetical protein Shew_3246 22 None None None 127511297 Common - nucleotidase Shew_0363 116 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 127511641 Common - YbaK/prolyl-tRNA synthetase associated region Shew_0707 26 COG2606 EbsC, Uncharacterized conserved protein Function unknown 127511820 Common - hypothetical protein Shew_0886 5 None None None 127511234 Common - sodium:neurotransmitter symporter Shew_0300 88 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 127514552 Nonpathogen - hypothetical protein Shew_3624 4 None None None 127511573 Common - hypothetical protein Shew_0639 5 None None None 127514492 Common - hypothetical protein Shew_3564 2 None None None 127511620 Common - DSBA oxidoreductase Shew_0686 31 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 127511047 Common - CheA signal transduction histidine kinase Shew_0113 148 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 127511271 Common rho transcription termination factor Rho Shew_0337 200 COG1158 Rho, Transcription termination factor Transcription 127513726 Common - trimethylamine-N-oxide reductase TorA Shew_2798 165 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 127511957 Common - protein of unknown function UPF0126 Shew_1024 133 COG2860 COG2860, Predicted membrane protein Function unknown 127514660 Common - Microbial collagenase Shew_3732 15 None None None 127514385 Common - UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase Shew_3457 212 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 127512754 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Shew_1826 202 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 127514792 Common - protein of unknown function DUF37 Shew_3867 185 COG0759 COG0759, Uncharacterized conserved protein Function unknown 127512987 Common - hypothetical protein Shew_2059 6 None None None 127512872 Common - ferredoxin Shew_1944 31 COG0633 Fdx, Ferredoxin Energy production and conversion 127513441 Common - UDP-2,3-diacylglucosamine hydrolase Shew_2513 77 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 127514263 Common - nitrite reductase, copper-containing Shew_3335 47 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 127511924 Common - Resolvase, N-terminal domain Shew_0991 126 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 127511522 Common - protein of unknown function UPF0270 Shew_0588 1 COG3089 COG3089, Uncharacterized protein conserved in bacteria Function unknown 127513823 Common - 2-dehydropantoate 2-reductase Shew_2895 99 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 127514237 Common - OstA family protein Shew_3309 42 COG1934 COG1934, Uncharacterized protein conserved in bacteria Function unknown 127512907 Common - putative dienelactone hydrolase-related enzyme Shew_1979 51 COG1073 COG1073, Hydrolases of the alpha/beta superfamily General function prediction only 127513561 Common pyrH uridylate kinase Shew_2633 233 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 127511778 Common nrfA cytochrome c nitrite reductase Shew_0844 40 COG3303 NrfA, Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit Inorganic ion transport and metabolism 127512770 Common - SirA family protein Shew_1842 6 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 127512485 Common - hypothetical protein Shew_1556 3 None None None 127512560 Common - hypothetical protein Shew_1631 8 None None None 127514640 Common - Rhomboid family protein Shew_3712 40 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 127513514 Common - amidohydrolase Shew_2586 42 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 127511389 Common - uncharacterized protein UPF0114 Shew_0455 19 COG2862 COG2862, Predicted membrane protein Function unknown 127513598 Common - transcriptional regulator, LysR family Shew_2670 156 COG0583 LysR, Transcriptional regulator Transcription 127511560 Common - protein of unknown function DUF350 Shew_0626 6 None None None 127514669 Common - putative SAM-dependent methyltransferase Shew_3741 28 COG3129 COG3129, Predicted SAM-dependent methyltransferase General function prediction only 127511529 Nonpathogen - hypothetical protein Shew_0595 2 None None None 127511072 Common - tRNA (uracil-5-)-methyltransferase Shew_0138 166 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 127513900 Common - hypothetical protein Shew_2972 4 None None None 127514528 Common - alpha/beta hydrolase fold Shew_3600 158 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 127513064 Common - Carboxylesterase Shew_2136 84 COG0400 COG0400, Predicted esterase General function prediction only 127513039 Common - DNA polymerase III, epsilon subunit Shew_2111 185 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 127512934 Common - GCN5-related N-acetyltransferase Shew_2006 4 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 127514106 Common - Na+/H+ antiporter NhaC Shew_3178 73 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 127514477 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Shew_3549 77 COG0348 NapH, Polyferredoxin Energy production and conversion 127512414 Nonpathogen - hypothetical protein Shew_1485 1 None None None 127512974 Common - phosphogluconate dehydratase Shew_2046 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 127512138 Common - Septum formation initiator Shew_1206 65 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 127512222 Common ispG 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase Shew_1290 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 127511038 Common - protein of unknown function DUF333 Shew_0104 11 COG3042 Hlx, Putative hemolysin General function prediction only 127514474 Common - hypothetical protein Shew_3546 7 None None None 127512120 Common - riboflavin synthase subunit alpha Shew_1188 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 127512824 Common - lipoprotein, putative Shew_1896 6 None None None 127512204 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Shew_1272 7 COG2243 CobF, Precorrin-2 methylase Coenzyme metabolism 127512048 Common - Beta-N-acetylhexosaminidase Shew_1115 45 COG3525 Chb, N-acetyl-beta-hexosaminidase Carbohydrate transport and metabolism 127514309 Common - diguanylate cyclase Shew_3381 179 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 127512343 Common - tetratricopeptide TPR_2 Shew_1412 25 COG3754 RgpF, Lipopolysaccharide biosynthesis protein Cell envelope biogenesis, outer membrane 127511452 Common - protein of unknown function DUF81 Shew_0518 45 None None None 127511429 Nonpathogen - hypothetical protein Shew_0495 2 None None None 127514469 Common - thioesterase domain, putative Shew_3541 35 None None None 127512793 Common - phosphoenolpyruvate-protein phosphotransferase Shew_1865 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 127512014 Common - threonine synthase Shew_1081 171 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 127511352 Common - arsenical-resistance protein Shew_0418 141 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 127513082 Common - homogentisate 1,2-dioxygenase Shew_2154 52 COG3508 HmgA, Homogentisate 1,2-dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 127514541 Common - general secretion pathway protein J Shew_3613 30 COG4795 PulJ, Type II secretory pathway, component PulJ Intracellular trafficking and secretion 127512266 Common - hypothetical protein Shew_1335 2 None None None 127513793 Common - transcriptional regulator, TetR family Shew_2865 13 COG1309 AcrR, Transcriptional regulator Transcription 127513778 Common - hypothetical protein Shew_2850 1 None None None 127511599 Common - sulfite reductase (NADPH) flavoprotein, alpha chain Shew_0665 106 COG0369 CysJ, Sulfite reductase, alpha subunit (flavoprotein) Inorganic ion transport and metabolism 127512922 Common - universal stress protein UspE Shew_1994 84 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 127513176 Common - chromosome segregation and condensation protein ScpA Shew_2248 138 COG1354 COG1354, Uncharacterized conserved protein Function unknown 127511888 Common - peptidase M24 Shew_0955 248 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 127514720 Nonpathogen - hypothetical protein Shew_3792 1 None None None 127513047 Common - methyl-accepting chemotaxis sensory transducer Shew_2119 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127511930 Common - DNA primase Shew_0997 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 127513688 Common - isocitrate dehydrogenase Shew_2760 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 127514517 Common - transcriptional regulator, LysR family Shew_3589 106 COG0583 LysR, Transcriptional regulator Transcription 127513495 Common - MORN variant repeat protein Shew_2567 27 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 127511466 Common - peptidase M28 Shew_0532 65 COG2234 Iap, Predicted aminopeptidases General function prediction only 127513149 Nonpathogen - hypothetical protein Shew_2221 1 None None None 127513527 Common - transcriptional regulator, HxlR family Shew_2599 12 COG1733 COG1733, Predicted transcriptional regulators Transcription 127513547 Common - tRNA(Ile)-lysidine synthetase Shew_2619 209 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 127511345 Common - outer membrane efflux protein Shew_0411 35 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 127512783 Nonpathogen - hypothetical protein Shew_1855 1 None None None 127512378 Common - glutamyl-tRNA synthetase Shew_1449 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 127513365 Common - hypothetical protein Shew_2437 22 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 127512274 Common - response regulator receiver modulated CheW protein Shew_1343 188 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 127511881 Common - hypothetical protein Shew_0948 7 None None None 127511081 Common rplK 50S ribosomal protein L11 Shew_0147 247 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 127513984 Common - hypothetical protein Shew_3056 4 None None None 127511120 Common - cytochrome c-type biogenesis protein CcmE Shew_0186 92 COG2332 CcmE, Cytochrome c-type biogenesis protein CcmE Posttranslational modification, protein turnover, chaperones 127512815 Common - alpha amylase, catalytic region Shew_1887 153 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 127511753 Common - protein of unknown function DUF1696 Shew_0819 29 None None None 127511517 Common - two component transcriptional regulator, winged helix family Shew_0583 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127511674 Common - L-serine dehydratase 1 Shew_0740 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 127514453 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase Shew_3525 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 127511145 Common - Pilus assembly protein, PilQ Shew_0211 37 COG3168 PilP, Tfp pilus assembly protein PilP Cell motility and secretion / Intracellular trafficking and secretion 127512392 Common - transcriptional regulator, AraC family Shew_1463 126 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 127514083 Common - hypothetical protein Shew_3155 1 None None None 127511596 Common - NAD(P) transhydrogenase, beta subunit Shew_0662 123 COG1282 PntB, NAD/NADP transhydrogenase beta subunit Energy production and conversion 127512929 Common - hypothetical protein Shew_2001 7 None None None 127512021 Common pgi glucose-6-phosphate isomerase Shew_1088 200 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 127512368 Common - maleylacetoacetate isomerase Shew_1439 94 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 127512553 Common cysB transcriptional regulator CysB Shew_1624 187 COG0583 LysR, Transcriptional regulator Transcription 127511128 Common - periplasmic protein thiol--disulphide oxidoreductase DsbE Shew_0194 120 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 127512253 Common - short-chain dehydrogenase/reductase SDR Shew_1322 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 127514324 Nonpathogen - hypothetical protein Shew_3396 2 None None None 127513773 Common - protein of unknown function DUF6, transmembrane Shew_2845 15 COG2962 RarD, Predicted permeases General function prediction only 127513734 Common - GCN5-related N-acetyltransferase Shew_2806 93 COG3153 COG3153, Predicted acetyltransferase General function prediction only 127514429 Common - tRNA guanosine-2'-O-methyltransferase Shew_3501 189 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 127511252 Common hemC porphobilinogen deaminase Shew_0318 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 127512590 Common fur ferric uptake regulator Shew_1661 199 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 127513483 Common - hypothetical protein Shew_2555 7 COG3126 COG3126, Uncharacterized protein conserved in bacteria Function unknown 127512334 Common - dTDP-4-dehydrorhamnose reductase Shew_1403 174 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 127512206 Common - diguanylate cyclase Shew_1274 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127514242 Common - hypothetical protein Shew_3314 140 COG1660 COG1660, Predicted P-loop-containing kinase General function prediction only 127513884 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Shew_2956 144 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 127514183 Nonpathogen - hypothetical protein Shew_3255 1 None None None 127513907 Common - putative iron-sulfur cluster binding protein Shew_2979 126 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 127512030 Common - integral membrane protein MviN Shew_1097 193 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 127513887 Common - transcriptional regulator, LysR family Shew_2959 191 COG0583 LysR, Transcriptional regulator Transcription 127513642 Common - hypothetical protein Shew_2714 3 None None None 127514750 Common - AAA ATPase, central domain protein Shew_3822 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 127511402 Common - transcriptional regulator, LysR family Shew_0468 162 COG0583 LysR, Transcriptional regulator Transcription 127513457 Common - pseudouridine synthase Shew_2529 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 127511727 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Shew_0793 249 COG3634 AhpF, Alkyl hydroperoxide reductase, large subunit Posttranslational modification, protein turnover, chaperones 127514112 Common - hypothetical protein Shew_3184 2 None None None 127511891 Common - hypothetical protein Shew_0958 2 None None None 127514592 Common - alpha-L-glutamate ligases, RimK family Shew_3664 157 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 127514015 Common - lipid A ABC exporter family, fused ATPase and inner membrane subunits Shew_3087 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 127514737 Common - protein of unknown function DUF610, YibQ Shew_3809 66 COG2861 COG2861, Uncharacterized protein conserved in bacteria Function unknown 127511262 Common - protein of unknown function DUF542, ScdA domain protein Shew_0328 45 COG2846 COG2846, Regulator of cell morphogenesis and NO signaling Cell division and chromosome partitioning 127512652 Common - heat shock protein HtpX Shew_1723 188 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 127512516 Common - DNA ligase Shew_1587 31 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 127514345 Common - hypothetical protein Shew_3417 8 None None None 127514619 Common - hypothetical protein Shew_3691 18 None None None 127513380 Common - DEAD/DEAH box helicase domain protein Shew_2452 239 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 127514729 Common - peptidase S41 Shew_3801 45 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 127514420 Common - Paraquat-inducible protein A Shew_3492 17 COG2995 PqiA, Uncharacterized paraquat-inducible protein A Function unknown 127511730 Common - hypothetical protein Shew_0796 1 None None None 127512691 Common - Ni/Fe-hydrogenase, b-type cytochrome subunit Shew_1763 44 COG1969 HyaC, Ni,Fe-hydrogenase I cytochrome b subunit Energy production and conversion 127511322 Common - MSHA biogenesis protein MshK Shew_0388 1 None None None 127512508 Common - dTMP kinase Shew_1579 226 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 127511746 Common lysS lysyl-tRNA synthetase Shew_0812 249 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 127512738 Common - dihydroorotate dehydrogenase 2 Shew_1810 212 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 127514580 Common - LemA family protein Shew_3652 131 COG1704 LemA, Uncharacterized conserved protein Function unknown 127514366 Common - type IV-A pilus assembly ATPase PilB Shew_3438 223 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 127513144 Common pheS phenylalanyl-tRNA synthetase subunit alpha Shew_2216 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 127511261 Common - HupE/UreJ protein Shew_0327 46 COG2370 HupE, Hydrogenase/urease accessory protein Posttranslational modification, protein turnover, chaperones 127514409 Common - DNA repair protein RadC Shew_3481 179 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 127513972 Common - methyl-accepting chemotaxis sensory transducer Shew_3044 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127511707 Common - fructose-1,6-bisphosphatase Shew_0773 108 COG0158 Fbp, Fructose-1,6-bisphosphatase Carbohydrate transport and metabolism 127511052 Common - cytochrome oxidase assembly Shew_0118 67 COG1612 CtaA, Uncharacterized protein required for cytochrome oxidase assembly Posttranslational modification, protein turnover, chaperones 127511268 Common - fumarate reductase Shew_0334 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 127511379 Common - hypothetical protein Shew_0445 1 None None None 127514784 Common - Inosine/uridine-preferring nucleoside hydrolase Shew_3859 86 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 127511588 Common - peptidase M16 domain protein Shew_0654 7 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 127513677 Common - two component transcriptional regulator, winged helix family Shew_2749 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127512731 Common - aminopeptidase N Shew_1803 161 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 127513404 Common - MotA/TolQ/ExbB proton channel Shew_2476 85 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 127513198 Common - alpha/beta hydrolase fold Shew_2270 28 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 127512866 Common - hypothetical protein Shew_1938 4 None None None 127513007 Common aspS aspartyl-tRNA synthetase Shew_2079 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 127511933 Common - putative metalloendopeptidase, glycoprotease family Shew_1000 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 127514486 Common - transcriptional regulator, AsnC family Shew_3558 159 COG1522 Lrp, Transcriptional regulators Transcription 127512028 Common - transcriptional regulator, ArsR family Shew_1095 167 COG0640 ArsR, Predicted transcriptional regulators Transcription 127511312 Common argS arginyl-tRNA synthetase Shew_0378 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 127514511 Common - Methyltransferase type 12 Shew_3583 20 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 127514536 Common - protein of unknown function DUF1145 Shew_3608 3 COG3776 COG3776, Predicted membrane protein Function unknown 127511611 Common - protein of unknown function DUF1111 Shew_0677 50 COG3488 COG3488, Predicted thiol oxidoreductase Energy production and conversion 127513274 Common - ABC transporter-related protein Shew_2346 249 COG3638 COG3638, ABC-type phosphate/phosphonate transport system, ATPase component Inorganic ion transport and metabolism 127514587 Common - hypothetical protein Shew_3659 1 None None None 127513805 Common - Na(+)-translocating NADH-quinone reductase subunit E Shew_2877 76 COG2209 NqrE, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE Energy production and conversion 127513725 Common - trimethylamine-N-oxide reductase c-type cytochrome TorC Shew_2797 49 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 127512630 Common - transcriptional regulator PhoU Shew_1701 189 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 127511394 Common - hypothetical protein Shew_0460 19 None None None 127512658 Common - Curli production assembly/transport component CsgG Shew_1729 17 COG1462 CsgG, Uncharacterized protein involved in formation of curli polymers Cell envelope biogenesis, outer membrane 127511827 Common - protein of unknown function DUF1289 Shew_0894 21 COG3313 COG3313, Predicted Fe-S protein General function prediction only 127512129 Common - Auxin Efflux Carrier Shew_1197 75 COG0679 COG0679, Predicted permeases General function prediction only 127511079 Common secE preprotein translocase subunit SecE Shew_0145 41 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 127512067 Common - protein of unknown function DUF167 Shew_1134 72 COG1872 COG1872, Uncharacterized conserved protein Function unknown 127513424 Common - phage shock protein A, PspA Shew_2496 63 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 127514225 Common - periplasmic serine protease DegS Shew_3297 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 127511816 Common - Organic solvent tolerance protein Shew_0882 124 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 127511603 Common - Redoxin domain protein Shew_0669 194 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 127511790 Common - Phosphoglycerate mutase Shew_0856 10 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 127511474 Common - Enoyl-CoA hydratase/isomerase Shew_0540 179 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 127513572 Common - protein of unknown function DUF446 Shew_2644 30 COG3098 COG3098, Uncharacterized protein conserved in bacteria Function unknown 127514155 Common - diguanylate cyclase/phosphodiesterase Shew_3227 179 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 127512541 Common - hypothetical protein Shew_1612 1 None None None 127512900 Common - FMN-binding domain protein Shew_1972 9 COG3976 COG3976, Uncharacterized protein conserved in bacteria Function unknown 127514193 Common - CutA1 divalent ion tolerance protein Shew_3265 120 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 127511336 Common - MSHA biogenesis protein MshQ Shew_0402 14 None None None 127511609 Common - hypothetical protein Shew_0675 19 None None None 127512599 Common - enoyl-CoA hydratase Shew_1670 185 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 127513619 Common - OmpA domain protein transmembrane region-containing protein Shew_2691 5 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 127513000 Common - endonuclease III Shew_2072 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 127511259 Common - tyrosine recombinase XerC Shew_0325 230 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 127511961 Common - hypothetical protein Shew_1028 4 None None None 127513810 Common - S-ribosylhomocysteinase Shew_2882 55 COG1854 LuxS, LuxS protein involved in autoinducer AI2 synthesis Signal transduction mechanisms 127513582 Common queF 7-cyano-7-deazaguanine reductase Shew_2654 70 COG2904 COG2904, Uncharacterized protein conserved in bacteria Function unknown 127511610 Common - putative lipoprotein Shew_0676 39 COG3489 COG3489, Predicted periplasmic lipoprotein General function prediction only 127511675 Common - GCN5-related N-acetyltransferase Shew_0741 10 COG0456 RimI, Acetyltransferases General function prediction only 127511194 Common - hypothetical protein Shew_0260 1 COG3115 ZipA, Cell division protein Cell division and chromosome partitioning 127513334 Common - transcriptional regulator, AraC family Shew_2406 73 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 127513989 Nonpathogen - hypothetical protein Shew_3061 1 None None None 127513352 Common - hypothetical protein Shew_2424 1 None None None 127514461 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Shew_3533 47 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 127512098 Common - iron-containing alcohol dehydrogenase Shew_1166 174 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 127512637 Common - protein of unknown function UPF0157 Shew_1708 39 COG2320 GrpB, Uncharacterized conserved protein Function unknown 127513238 Common - Nucleoside-diphosphate kinase Shew_2310 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 127513298 Common - Methyltransferase type 11 Shew_2370 29 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 127512236 Common - cyd operon protein YbgT Shew_1304 22 COG4890 COG4890, Predicted outer membrane lipoprotein Function unknown 127511567 Nonpathogen - hypothetical protein Shew_0633 1 None None None 127513113 Common - septum site-determining protein MinD Shew_2185 144 COG2894 MinD, Septum formation inhibitor-activating ATPase Cell division and chromosome partitioning 127512520 Common - bifunctional methionine sulfoxide reductase B/A protein Shew_1591 206 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 127511565 Common - AFG1-family ATPase Shew_0631 103 COG1485 COG1485, Predicted ATPase General function prediction only 127513013 Common - alpha-L-glutamate ligase-like protein Shew_2085 18 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 127511091 Common rpsJ 30S ribosomal protein S10 Shew_0157 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 127512174 Common - hypothetical protein Shew_1242 3 None None None 127511059 Common - cytochrome c oxidase, subunit II Shew_0125 159 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 127511065 Common - GCN5-related N-acetyltransferase Shew_0131 42 COG0456 RimI, Acetyltransferases General function prediction only 127512176 Common - OsmC family protein Shew_1244 91 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 127511495 Common - carbohydrate kinase, YjeF-related protein Shew_0561 222 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 127513157 Common - Ferrochelatase Shew_2229 156 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 127513915 Common - transcriptional regulator, LysR family Shew_2987 183 COG0583 LysR, Transcriptional regulator Transcription 127514430 Common - AMP-dependent synthetase and ligase Shew_3502 221 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 127511411 Nonpathogen - hypothetical protein Shew_0477 1 None None None 127511070 Common - Stearoyl-CoA 9-desaturase Shew_0136 59 COG1398 OLE1, Fatty-acid desaturase Lipid metabolism 127512831 Common - para-aminobenzoate synthase, subunit I Shew_1903 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 127513109 Common - hypothetical protein Shew_2181 74 COG2983 COG2983, Uncharacterized conserved protein Function unknown 127511901 Common - 3-mercaptopyruvate sulfurtransferase Shew_0968 144 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 127512501 Common - protein of unknown function DUF34 Shew_1572 111 COG0327 COG0327, Uncharacterized conserved protein Function unknown 127513791 Common - short-chain dehydrogenase/reductase SDR Shew_2863 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 127514439 Common - acyl carrier protein, putative Shew_3511 45 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127512321 Common - CheW protein Shew_1390 14 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 127513306 Common - cell division protein ZipA Shew_2378 43 COG3115 ZipA, Cell division protein Cell division and chromosome partitioning 127514168 Common - two component transcriptional regulator, LuxR family Shew_3240 215 COG4566 TtrR, Response regulator Signal transduction mechanisms 127511858 Common - hypothetical protein Shew_0925 4 None None None 127512855 Common - dihydrolipoamide acetyltransferase Shew_1927 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 127513073 Common - MscS Mechanosensitive ion channel Shew_2145 151 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 127512141 Common - Pseudouridylate synthase Shew_1209 86 COG0585 COG0585, Uncharacterized conserved protein Function unknown 127513866 Common - rare lipoprotein A Shew_2938 137 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 127512544 Common - ABC transporter-related protein Shew_1615 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 127511291 Common - copper ABC transporter, permease protein Shew_0357 29 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 127512249 Common - polysaccharide biosynthesis protein CapD Shew_1318 150 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 127513712 Common - phosphoesterase, PA-phosphatase related Shew_2784 19 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 127511558 Common - hypothetical protein Shew_0624 8 COG3789 COG3789, Uncharacterized protein conserved in bacteria Function unknown 127514211 Common - single-strand binding protein/primosomal replication protein N Shew_3283 22 COG2965 PriB, Primosomal replication protein N DNA replication, recombination, and repair 127512053 Common - cytochrome B561 Shew_1120 78 COG3038 CybB, Cytochrome B561 Energy production and conversion 127512148 Common - regulatory protein RecX Shew_1216 89 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 127511684 Nonpathogen - hypothetical protein Shew_0750 3 None None None 127511789 Common - hypothetical protein Shew_0855 1 None None None 127513732 Common - type IV pilus assembly PilZ Shew_2804 20 None None None 127514730 Common - HI0933 family protein Shew_3802 138 COG2081 COG2081, Predicted flavoproteins General function prediction only 127512215 Common - NrfJ-related protein Shew_1283 9 None None None 127511845 Nonpathogen - hypothetical protein Shew_0912 1 None None None 127511550 Common - SH3 domain protein domain protein Shew_0616 32 COG3103 COG3103, SH3 domain protein Signal transduction mechanisms 127511785 Common - phospho-2-dehydro-3-heoxyheptonate aldolase Shew_0851 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 127513536 Common - inner-membrane translocator Shew_2608 159 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 127510984 Common - choline/carnitine/betaine transporter Shew_0049 96 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 127511077 Common - pantothenate kinase Shew_0143 86 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 127512766 Common - DNA replication initiation factor Shew_1838 185 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 127514258 Common - diguanylate cyclase Shew_3330 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127514370 Common - hypothetical protein Shew_3442 44 COG4582 COG4582, Uncharacterized protein conserved in bacteria Function unknown 127511027 Common - molybdate ABC transporter, inner membrane subunit Shew_0093 230 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 127513504 Common - 3-oxoacid CoA-transferase, B subunit Shew_2576 94 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 127512308 Common - flagellar biosynthetic protein FliQ Shew_1377 43 COG1987 FliQ, Flagellar biosynthesis pathway, component FliQ Cell motility and secretion / Intracellular trafficking and secretion 127513399 Common - protein of unknown function DUF885 Shew_2471 44 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 127513168 Common - hypothetical protein Shew_2240 62 COG3220 COG3220, Uncharacterized protein conserved in bacteria Function unknown 127512676 Common - hypothetical protein Shew_1747 1 None None None 127512365 Common phhB pterin-4-alpha-carbinolamine dehydratase Shew_1436 81 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 127514123 Common - hypothetical protein Shew_3195 40 COG3647 COG3647, Predicted membrane protein Function unknown 127512981 Common - Peptidyl-dipeptidase A Shew_2053 16 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 127511362 Nonpathogen - hypothetical protein Shew_0428 1 None None None 127513233 Common - FolC bifunctional protein Shew_2305 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 127512577 Common - acriflavin resistance protein Shew_1648 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 127511882 Common - Redoxin domain protein Shew_0949 79 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 127513659 Nonpathogen - hypothetical protein Shew_2731 1 None None None 127514284 Common - heavy metal efflux pump, CzcA family Shew_3356 177 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 127513415 Common - histone deacetylase superfamily Shew_2487 161 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 127513479 Common - homoserine O-succinyltransferase Shew_2551 64 COG1897 MetA, Homoserine trans-succinylase Amino acid transport and metabolism 127513992 Common gcvT glycine cleavage system aminomethyltransferase T Shew_3064 178 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 127512957 Common rplT 50S ribosomal protein L20 Shew_2029 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 127512748 Common prpB 2-methylisocitrate lyase Shew_1820 136 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 127512167 Common - hypothetical protein Shew_1235 4 None None None 127514314 Common - band 7 protein Shew_3386 216 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 127511331 Common - methylation site containing protein Shew_0397 8 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 127511485 Common - DNA topoisomerase IV subunit A Shew_0551 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 127513187 Common - metal dependent phosphohydrolase Shew_2259 120 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 127511970 Common - DNA mismatch repair protein Shew_1037 30 COG3066 MutH, DNA mismatch repair protein DNA replication, recombination, and repair 127512269 Common - hypothetical protein Shew_1338 9 None None None 127511221 Common - DNA-binding transcriptional regulator IlvY Shew_0287 189 COG0583 LysR, Transcriptional regulator Transcription 127514561 Nonpathogen - hypothetical protein Shew_3633 1 None None None 127511896 Common - hypothetical protein Shew_0963 37 None None None 127511994 Common - cytochrome c assembly protein Shew_1061 63 COG4137 COG4137, ABC-type uncharacterized transport system, permease component General function prediction only 127512242 Common - acriflavin resistance protein Shew_1311 178 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 127513760 Common - phosphoglucosamine mutase Shew_2832 241 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 127512605 Common - ABC transporter-related protein Shew_1676 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 127514457 Common - azoreductase Shew_3529 98 COG1182 AcpD, Acyl carrier protein phosphodiesterase Lipid metabolism 127514590 Nonpathogen - hypothetical protein Shew_3662 1 None None None 127513570 Common - flavodoxin Shew_2642 75 COG0369 CysJ, Sulfite reductase, alpha subunit (flavoprotein) Inorganic ion transport and metabolism 127513490 Common - transcriptional regulator, MarR family Shew_2562 87 COG1846 MarR, Transcriptional regulators Transcription 127510996 Common - formate dehydrogenase, gamma subunit Shew_0061 63 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 127511140 Common - argininosuccinate lyase Shew_0206 224 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 127512800 Common - elongation factor G Shew_1872 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 127512248 Common - Tetratricopeptide TPR_2 repeat protein Shew_1317 18 COG2604 COG2604, Uncharacterized protein conserved in bacteria Function unknown 127513956 Common - phospholipase D/Transphosphatidylase Shew_3028 56 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 127513180 Common - glutamine amidotransferase of anthranilate synthase Shew_2252 232 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 127513961 Common - uncharacterized domain protein Shew_3033 50 COG1944 COG1944, Uncharacterized conserved protein Function unknown 127514654 Common - protein of unknown function DUF1488 Shew_3726 12 None None None 127512185 Common - retinol acyltransferase domain protein Shew_1253 12 None None None 127512809 Common - hypothetical protein Shew_1881 12 None None None 127513612 Common - hypothetical protein Shew_2684 2 None None None 127511871 Nonpathogen - TonB-dependent receptor Shew_0938 4 None None None 127514716 Common - multi-sensor hybrid histidine kinase Shew_3788 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127511757 Common - transcriptional regulator, LysR family Shew_0823 174 COG0583 LysR, Transcriptional regulator Transcription 127512751 Common - putative AcnD-accessory protein PrpF Shew_1823 55 COG2828 COG2828, Uncharacterized protein conserved in bacteria Function unknown 127511230 Common - heat shock protein Hsp20 Shew_0296 155 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 127511311 Common - Sporulation domain protein Shew_0377 29 COG3087 FtsN, Cell division protein Cell division and chromosome partitioning 127514567 Common - methyl-accepting chemotaxis sensory transducer Shew_3639 88 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127511637 Common - response regulator receiver protein Shew_0703 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 127513902 Common - transferase hexapeptide repeat containing protein Shew_2974 86 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 127511384 Common - 1-acyl-sn-glycerol-3-phosphate acyltransferase Shew_0450 129 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 127511414 Nonpathogen - Sel1 domain protein repeat-containing protein Shew_0480 2 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 127511498 Common - DNA mismatch repair protein MutL Shew_0564 191 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 127514545 Common - general secretion pathway protein F Shew_3617 141 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 127510963 Common - transcriptional regulator, LysR family Shew_0028 154 COG0583 LysR, Transcriptional regulator Transcription 127514752 Common - hypothetical protein Shew_3824 7 None None None 127512328 Common - amino acid/peptide transporter Shew_1397 79 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 127511846 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Shew_0913 9 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 127511156 Common - transcriptional regulator, LysR family Shew_0222 164 COG0583 LysR, Transcriptional regulator Transcription 127512286 Common flgL flagellar hook-associated protein FlgL Shew_1355 101 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 127512588 Common - ferredoxin-dependent glutamate synthase Shew_1659 202 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 127514347 Common - two component transcriptional regulator, winged helix family Shew_3419 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127514422 Common - aminoglycoside phosphotransferase Shew_3494 19 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 127512788 Common - alpha/beta hydrolase fold Shew_1860 156 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 127514444 Common - glycosyl transferase, family 2 Shew_3516 139 COG4261 COG4261, Predicted acyltransferase General function prediction only 127514709 Common - ABC transporter-related protein Shew_3781 249 COG4555 NatA, ABC-type Na+ transport system, ATPase component Energy production and conversion / Inorganic ion transport and metabolism 127511652 Common - cob(I)yrinic acid a,c-diamide adenosyltransferase Shew_0718 142 COG2109 BtuR, ATP:corrinoid adenosyltransferase Coenzyme metabolism 127512491 Common - Pseudouridylate synthase Shew_1562 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 127514027 Common - transcriptional regulator, TetR family Shew_3099 102 COG1309 AcrR, Transcriptional regulator Transcription 127514095 Common - hypothetical protein Shew_3167 1 None None None 127513289 Common - proline racemase Shew_2361 47 COG3938 COG3938, Proline racemase Amino acid transport and metabolism 127512443 Common upp uracil phosphoribosyltransferase Shew_1514 164 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 127514610 Common - two component, sigma54 specific, transcriptional regulator, Fis family Shew_3682 210 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 127513269 Common - two component, sigma54 specific, transcriptional regulator, Fis family Shew_2341 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 127512662 Common - thioesterase superfamily protein Shew_1733 30 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 127514501 Common - GAF modulated sigma54 specific transcriptional regulator, Fis family Shew_3573 177 COG3284 AcoR, Transcriptional activator of acetoin/glycerol metabolism Secondary metabolites biosynthesis, transport, and catabolism / Transcription 127512625 Common - protein of unknown function DUF6, transmembrane Shew_1696 122 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 127511464 Common - FAD dependent oxidoreductase Shew_0530 99 COG0579 COG0579, Predicted dehydrogenase General function prediction only 127513098 Common - Endonuclease/exonuclease/phosphatase Shew_2170 60 COG2374 COG2374, Predicted extracellular nuclease General function prediction only 127514702 Common - acetyltransferase-like Shew_3774 11 COG2388 COG2388, Predicted acetyltransferase General function prediction only 127511965 Common gltB glutamate synthase subunit alpha Shew_1032 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 127513222 Nonpathogen - hypothetical protein Shew_2294 2 COG3459 COG3459, Cellobiose phosphorylase Carbohydrate transport and metabolism 127512001 Common tyrA bifunctional chorismate mutase/prephenate dehydrogenase Shew_1068 77 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 127513210 Common - transcriptional regulator, Fis family Shew_2282 169 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 127514232 Common - ABC transporter-related protein Shew_3304 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 127514489 Common - nitrogen metabolism transcriptional regulator, NtrC, Fis Family Shew_3561 220 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 127511866 Common - Methyltransferase type 11 Shew_0933 101 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 127511022 Common - molybdenum cofactor biosynthesis protein B Shew_0088 188 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 127511539 Common - hypothetical protein Shew_0605 3 None None None 127512995 Common - electron transport complex, RnfABCDGE type, B subunit Shew_2067 121 COG2878 COG2878, Predicted NADH:ubiquinone oxidoreductase, subunit RnfB Energy production and conversion 127511908 Common - binding-protein-dependent transport systems inner membrane component Shew_0975 210 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 127512869 Common - signal peptide peptidase SppA, 67K type Shew_1941 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 127513021 Common - thiamine biosynthesis protein ThiS Shew_2093 2 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 127511450 Common - cytochrome c family protein Shew_0516 2 COG3258 COG3258, Cytochrome c Energy production and conversion 127513169 Common - hypothetical protein Shew_2241 2 None None None 127512699 Common - Nitrate reductase cytochrome c-type subunit (NapB) Shew_1771 39 COG3043 NapB, Nitrate reductase cytochrome c-type subunit Energy production and conversion 127512191 Common - phage transcriptional regulator, AlpA Shew_1259 4 COG3311 AlpA, Predicted transcriptional regulator Transcription 127511971 Common - dinucleoside polyphosphate hydrolase Shew_1038 113 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 127513091 Common - protein of unknown function DUF938 Shew_2163 49 None None None 127512649 Common - 8-amino-7-oxononanoate synthase Shew_1720 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 127511306 Common - hypothetical protein Shew_0372 4 None None None 127512973 Common - keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase Shew_2045 126 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 127513607 Common - FAD dependent oxidoreductase Shew_2679 153 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 127514524 Common - Methyltransferase type 11 Shew_3596 54 COG4798 COG4798, Predicted methyltransferase General function prediction only 127511147 Common - Shikimate kinase Shew_0213 201 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 127513485 Common - short-chain dehydrogenase/reductase SDR Shew_2557 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 127513861 Common - iojap-like protein Shew_2933 201 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 127514272 Common - dTDP-4-dehydrorhamnose reductase Shew_3344 165 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 127513130 Common - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase Shew_2202 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 127511117 Common - DNA-directed RNA polymerase subunit alpha Shew_0183 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 127513215 Common - galactokinase Shew_2287 91 COG0153 GalK, Galactokinase Carbohydrate transport and metabolism 127512427 Common - protein of unknown function DUF1538 Shew_1498 23 None None None 127513683 Common - conserved hypothetical protein 730 Shew_2755 41 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 127514338 Common - permease Shew_3410 80 COG0701 COG0701, Predicted permeases General function prediction only 127510971 Common - phosphoesterase, PA-phosphatase related Shew_0036 100 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 127512402 Common - hypothetical protein Shew_1473 15 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 127514136 Common napH quinol dehydrogenase membrane component Shew_3208 71 COG0348 NapH, Polyferredoxin Energy production and conversion 127512772 Common - chromosome replication initiation inhibitor protein Shew_1844 118 COG0583 LysR, Transcriptional regulator Transcription 127513999 Common - lipoprotein Shew_3071 11 COG3015 CutF, Uncharacterized lipoprotein NlpE involved in copper resistance Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism 127511016 Common - hypothetical protein Shew_0082 3 None None None 127512115 Common - putative ABC transporter ATP-binding protein Shew_1183 246 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 127513625 Common - hypothetical protein Shew_2697 35 None None None 127511214 Common - transcriptional regulator, GntR family Shew_0280 122 COG1802 GntR, Transcriptional regulators Transcription 127513108 Nonpathogen - hypothetical protein Shew_2180 6 None None None 127512477 Common - hypothetical protein Shew_1548 113 COG1806 COG1806, Uncharacterized protein conserved in bacteria Function unknown 127512381 Common - transcriptional regulator, AraC family Shew_1452 123 COG2169 Ada, Adenosine deaminase Nucleotide transport and metabolism 127514292 Common - acetyl-CoA carboxylase, biotin carboxyl carrier protein Shew_3364 183 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 127514682 Common - hypothetical protein Shew_3754 3 None None None 127511911 Common - band 7 protein Shew_0978 126 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 127513367 Common - efflux transporter, RND family, MFP subunit Shew_2439 144 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 127512667 Common - aminoglycoside phosphotransferase Shew_1738 6 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 127514579 Common - hypothetical protein Shew_3651 9 None None None 127512095 Common - efflux transporter, RND family, MFP subunit Shew_1163 161 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 127513939 Common - magnesium transporter Shew_3011 170 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 127512450 Common - OmpA/MotB domain protein Shew_1521 118 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 127513466 Common - AzlC family protein Shew_2538 99 COG1296 AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) Amino acid transport and metabolism 127511441 Common - NADH:flavin oxidoreductase/NADH oxidase Shew_0507 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 127512761 Common - putative serine protein kinase, PrkA Shew_1833 71 COG2766 PrkA, Putative Ser protein kinase Signal transduction mechanisms 127512531 Common - malonyl CoA-acyl carrier protein transacylase Shew_1602 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 127512383 Common - DEAD/DEAH box helicase domain protein Shew_1454 242 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 127513697 Common - exodeoxyribonuclease VII, small subunit Shew_2769 118 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 127510941 Common - LamB/YcsF family protein Shew_0006 100 COG1540 COG1540, Uncharacterized proteins, homologs of lactam utilization protein B General function prediction only 127511621 Common - heat shock protein DnaJ domain protein Shew_0687 38 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 127513934 Common - hypothetical protein Shew_3006 29 COG1556 COG1556, Uncharacterized conserved protein Function unknown 127513986 Common - beta-lactamase Shew_3058 113 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 127512939 Common - acriflavin resistance protein Shew_2011 178 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 127510954 Common fadB multifunctional fatty acid oxidation complex subunit alpha Shew_0019 182 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 127513221 Common - tryptophan halogenase Shew_2293 17 None None None 127513840 Common prfA peptide chain release factor 1 Shew_2912 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 127514741 Common - hypothetical protein Shew_3813 1 None None None 127512187 Common - hypothetical protein Shew_1255 5 None None None 127513947 Common - zinc carboxypeptidase-related protein Shew_3019 16 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 127511457 Common - cytochrome c family protein Shew_0523 61 COG2863 COG2863, Cytochrome c553 Energy production and conversion 127513661 Common - GCN5-related N-acetyltransferase Shew_2733 10 COG0456 RimI, Acetyltransferases General function prediction only 127511113 Common rpmJ 50S ribosomal protein L36 Shew_0179 137 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 127511743 Common - formate dehydrogenase, alpha subunit Shew_0809 232 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 127511804 Common rpmA 50S ribosomal protein L27 Shew_0870 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 127511536 Common - Methyltransferase type 12 Shew_0602 11 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 127513831 Common - hypothetical protein Shew_2903 25 None None None 127514065 Common - hypothetical protein Shew_3137 1 None None None 127514500 Common - Alcohol dehydrogenase GroES domain protein Shew_3572 130 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 127514032 Common - transcriptional regulator, TetR family Shew_3104 136 COG1309 AcrR, Transcriptional regulator Transcription 127511088 Common - 30S ribosomal protein S7 Shew_0154 243 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 127514042 Common - two component, sigma54 specific, transcriptional regulator, Fis family Shew_3114 195 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 127512100 Common - glycogen branching enzyme Shew_1168 146 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 127511543 Common - two component transcriptional regulator, LuxR family Shew_0609 206 COG4566 TtrR, Response regulator Signal transduction mechanisms 127511132 Common - competence/damage-inducible protein CinA Shew_0198 212 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 127512436 Common - 5-carboxymethyl-2-hydroxymuconate isomerase Shew_1507 19 COG3232 HpaF, 5-carboxymethyl-2-hydroxymuconate isomerase Amino acid transport and metabolism 127513974 Common - Carboxymuconolactone decarboxylase Shew_3046 85 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 127513509 Common - Peptidyl-dipeptidase Dcp Shew_2581 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 127513829 Common - phosphoesterase, PA-phosphatase related Shew_2901 4 None None None 127513765 Common - transcription elongation factor GreA Shew_2837 204 COG0782 GreA, Transcription elongation factor Transcription 127514572 Nonpathogen - hypothetical protein Shew_3644 1 None None None 127513195 Common - hypothetical protein Shew_2267 3 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 127513820 Common - major facilitator superfamily MFS_1 Shew_2892 109 None None None 127511489 Common - MscS Mechanosensitive ion channel Shew_0555 220 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 127513780 Common - aminoacyl-histidine dipeptidase Shew_2852 58 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 127512722 Common - sortase family protein Shew_1794 17 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 127513069 Common - lytic murein transglycosylase Shew_2141 105 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 127514288 Common - hypothetical protein Shew_3360 5 None None None 127513201 Common - transposase IS116/IS110/IS902 family protein Shew_2273 88 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 127513401 Common - tetratricopeptide domain protein Shew_2473 33 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 127512131 Common - protein of unknown function DUF416 Shew_1199 26 COG3068 COG3068, Uncharacterized protein conserved in bacteria Function unknown 127513133 Common - diguanylate cyclase Shew_2205 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127513202 Common - AAA ATPase Shew_2274 16 COG3593 COG3593, Predicted ATP-dependent endonuclease of the OLD family DNA replication, recombination, and repair 127512456 Common - TolB, N-terminal domain protein Shew_1527 160 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 127511665 Common - protein of unknown function DUF395, YeeE/YedE Shew_0731 61 COG2391 COG2391, Predicted transporter component General function prediction only 127512826 Common - ApbE family lipoprotein Shew_1898 138 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 127511696 Common - hypothetical protein Shew_0762 8 None None None 127513806 Common - Na(+)-translocating NADH-quinone reductase subunit D Shew_2878 76 COG1347 NqrD, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD Energy production and conversion 127511419 Common - cold-shock DNA-binding domain protein Shew_0485 30 COG1278 CspC, Cold shock proteins Transcription 127512642 Common - 3-oxoacyl-(acyl carrier protein) synthase III Shew_1713 187 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 127512388 Common - hypothetical protein Shew_1459 1 None None None 127514557 Common - competence protein ComF Shew_3629 141 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 127514507 Nonpathogen - hypothetical protein Shew_3579 5 None None None 127512905 Common - diguanylate cyclase with PAS/PAC sensor Shew_1977 188 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127514647 Common - hypothetical protein Shew_3719 12 None None None 127512180 Common - phosphoribosylaminoimidazole carboxylase, catalytic subunit Shew_1248 232 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 127513322 Common - phosphate acetyltransferase Shew_2394 173 COG0280 Pta, Phosphotransacetylase Energy production and conversion 127512685 Common - hydrogenase expression/formation protein HypD Shew_1757 108 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 127511029 Common - conserved hypothetical protein 156 Shew_0095 27 COG3111 COG3111, Uncharacterized conserved protein Function unknown 127514526 Common - transcriptional regulator, AsnC family Shew_3598 149 COG1522 Lrp, Transcriptional regulators Transcription 127514780 Common gidB glucose-inhibited division protein B Shew_3855 198 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 127511426 Common - methyl-accepting chemotaxis sensory transducer Shew_0492 156 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127512295 Common - two component, sigma54 specific, transcriptional regulator, Fis family Shew_1364 222 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 127512949 Common - CrcB protein Shew_2021 179 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 127513318 Common - formate acetyltransferase Shew_2390 57 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 127514789 Common - hypothetical protein Shew_3864 31 None None None 127514340 Common purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Shew_3412 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 127513428 Common - binding-protein-dependent transport systems inner membrane component Shew_2500 220 COG4171 SapC, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 127511166 Common - hypothetical protein Shew_0232 1 COG3788 COG3788, Uncharacterized relative of glutathione S-transferase, MAPEG superfamily General function prediction only 127511515 Common - hypothetical protein Shew_0581 22 None None None 127511122 Common - heme exporter protein CcmC Shew_0188 114 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 127514484 Common - aminotransferase, class V Shew_3556 136 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 127511343 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Shew_0409 204 COG0388 COG0388, Predicted amidohydrolase General function prediction only 127511658 Common - protein of unknown function DUF214 Shew_0724 80 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 127513795 Common - pyruvate carboxylase, propionyl-CoA carboxylase Shew_2867 233 COG1038 PycA, Pyruvate carboxylase Energy production and conversion 127512371 Common - two component, sigma54 specific, transcriptional regulator, Fis family Shew_1442 223 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 127512419 Common - ErfK/YbiS/YcfS/YnhG family protein Shew_1490 58 COG3034 COG3034, Uncharacterized protein conserved in bacteria Function unknown 127513786 Common - acetyl-CoA acetyltransferase Shew_2858 167 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 127514307 Common - hypothetical protein Shew_3379 4 None None None 127514007 Common - Polyphosphate kinase Shew_3079 161 COG0855 Ppk, Polyphosphate kinase Inorganic ion transport and metabolism 127514543 Common - general secretion pathway protein H Shew_3615 9 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 127510952 Common - GCN5-related N-acetyltransferase Shew_0017 17 COG0456 RimI, Acetyltransferases General function prediction only 127514229 Common - toluene tolerance family protein Shew_3301 77 COG2854 Ttg2D, ABC-type transport system involved in resistance to organic solvents, auxiliary component Secondary metabolites biosynthesis, transport, and catabolism 127511704 Common - tyrosine recombinase XerD Shew_0770 230 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 127513363 Common - sodium/proline symporter Shew_2435 183 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 127514479 Common - drug resistance transporter, Bcr/CflA subfamily Shew_3551 140 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 127511356 Common - hypothetical protein Shew_0422 17 None None None 127511247 Common - putative outer membrane adhesin like proteiin Shew_0313 140 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 127511771 Common - Tetratricopeptide TPR_2 repeat protein Shew_0837 26 COG3014 COG3014, Uncharacterized protein conserved in bacteria Function unknown 127512463 Common - integral membrane sensor hybrid histidine kinase Shew_1534 219 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 127511285 Common - Tetratricopeptide TPR_2 repeat protein Shew_0351 17 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 127512920 Common - hypothetical protein Shew_1992 68 COG2836 COG2836, Uncharacterized conserved protein Function unknown 127513156 Common - Inosine kinase Shew_2228 52 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 127512136 Common - CTP synthetase Shew_1204 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 127511354 Common - major facilitator superfamily MFS_1 Shew_0420 30 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 127514670 Common - flagellar basal body-associated protein FliL-like protein Shew_3742 16 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 127511174 Common - cytoplasmic chaperone TorD family protein Shew_0240 18 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 127511718 Common - hypothetical protein Shew_0784 1 None None None 127511798 Common - Dyp-type peroxidase family Shew_0864 57 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 127510937 Common - DNA polymerase III, beta subunit Shew_0002 215 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 127511329 Common - methylation site containing protein Shew_0395 7 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 127514230 Common - Mammalian cell entry related domain protein Shew_3302 63 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 127512813 Common - hypothetical protein Shew_1885 15 None None None 127511143 Common - Fimbrial assembly family protein Shew_0209 38 COG3166 PilN, Tfp pilus assembly protein PilN Cell motility and secretion / Intracellular trafficking and secretion 127513559 Common - undecaprenyl diphosphate synthase Shew_2631 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 127512795 Common - hypothetical protein Shew_1867 20 COG3603 COG3603, Uncharacterized conserved protein Function unknown 127514432 Common - TPR repeat-containing protein Shew_3504 5 COG3938 COG3938, Proline racemase Amino acid transport and metabolism 127512785 Common - iron-containing alcohol dehydrogenase Shew_1857 152 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 127512412 Common - protein of unknown function DUF1365 Shew_1483 63 COG3496 COG3496, Uncharacterized conserved protein Function unknown 127512202 Common - protein of unknown function UPF0125 Shew_1270 64 COG2914 COG2914, Uncharacterized protein conserved in bacteria Function unknown 127512565 Common - hypothetical protein Shew_1636 44 COG3216 COG3216, Uncharacterized protein conserved in bacteria Function unknown 127511755 Common - mitomycin resistance protein Shew_0821 11 None None None 127512985 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Shew_2057 179 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 127514686 Common - transcriptional regulator, histidine utilization repressor, GntR family Shew_3758 113 COG2188 PhnF, Transcriptional regulators Transcription 127512558 Common - hypothetical protein Shew_1629 8 None None None 127513875 Nonpathogen - hypothetical protein Shew_2947 2 None None None 127512290 Common - flagellar hook-associated 2 domain protein Shew_1359 103 COG1345 FliD, Flagellar capping protein Cell motility and secretion 127514718 Common - response regulator receiver modulated diguanylate cyclase Shew_3790 221 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 127512340 Common - hypothetical protein Shew_1409 16 None None None 127512697 Common - NapD family protein Shew_1769 20 COG3062 NapD, Uncharacterized protein involved in formation of periplasmic nitrate reductase Inorganic ion transport and metabolism 127513436 Common clpP ATP-dependent Clp protease proteolytic subunit Shew_2508 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 127513506 Common - extracellular solute-binding protein, family 3 Shew_2578 148 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 127511943 Common - general secretion pathway protein B Shew_1010 8 None None None 127512896 Common - beta-lactamase Shew_1968 130 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 127513567 Nonpathogen - hypothetical protein Shew_2639 2 None None None 127513812 Common - glycine cleavage system regulatory protein-like protein Shew_2884 9 COG2716 GcvR, Glycine cleavage system regulatory protein Amino acid transport and metabolism 127513148 Common - hypothetical protein Shew_2220 10 None None None 127514357 Common - dihydrolipoamide dehydrogenase Shew_3429 245 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 127512376 Common - major facilitator superfamily MFS_1 Shew_1447 9 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 127511056 Common - cytochrome c oxidase, subunit III Shew_0122 155 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 127512551 Common - pyridoxamine 5'-phosphate oxidase Shew_1622 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 127513741 Common - phosphopentomutase Shew_2813 70 COG1015 DeoB, Phosphopentomutase Carbohydrate transport and metabolism 127512332 Common - dTDP-glucose 4,6 dehydratase Shew_1401 232 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 127514383 Common - UDP-N-acetylmuramoylalanine--D-glutamate ligase Shew_3455 211 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 127512580 Common - succinate dehydrogenase, cytochrome b subunit Shew_1651 78 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 127511926 Common - Eco57I restriction endonuclease Shew_0993 58 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 127514696 Common - hypothetical protein Shew_3768 15 None None None 127512639 Common - protein of unknown function DUF1289 Shew_1710 11 COG3313 COG3313, Predicted Fe-S protein General function prediction only 127511996 Common rpsP 30S ribosomal protein S16 Shew_1063 212 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 127512752 Common - response regulator Shew_1824 214 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 127513447 Common - cytochrome C family protein Shew_2519 35 None None None 127512779 Common - efflux transporter, RND family, MFP subunit Shew_1851 168 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 127512081 Common - hypothetical protein Shew_1148 5 COG3803 COG3803, Uncharacterized protein conserved in bacteria Function unknown 127512127 Common - hypothetical protein Shew_1195 1 None None None 127514158 Common - rRNA (guanine-N(2)-)-methyltransferase Shew_3230 110 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 127513970 Common - hypothetical protein Shew_3042 3 None None None 127513258 Common - carbon starvation protein CstA Shew_2330 109 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 127510943 Common - Allophanate hydrolase subunit 1 Shew_0008 100 COG2049 DUR1, Allophanate hydrolase subunit 1 Amino acid transport and metabolism 127511387 Common - response regulator receiver protein Shew_0453 204 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 127514180 Common - porin, Gram-negative type Shew_3252 28 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 127511538 Common - DEAD/DEAH box helicase domain protein Shew_0604 235 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 127512158 Common - peptidase M16 domain protein Shew_1226 189 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 127514711 Common - hypothetical protein Shew_3783 1 None None None 127512041 Common - methylation site containing protein Shew_1108 30 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 127512833 Common - peptidase S9, prolyl oligopeptidase active site domain protein Shew_1905 118 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 127512430 Common - glutaredoxin Shew_1501 21 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 127514662 Common - DNA protecting protein DprA Shew_3734 210 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 127512976 Common - glucose-6-phosphate 1-dehydrogenase Shew_2048 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 127513331 Common - Arylesterase Shew_2403 100 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 127511808 Common - Dihydrofolate reductase Shew_0874 149 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 127512700 Common - periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family Shew_1772 48 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 127513033 Common - methylated-DNA-(protein)-cysteine S-methyltransferase Shew_2105 66 COG3695 COG3695, Predicted methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 127511045 Common - methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor Shew_0111 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127513731 Common - DNA-binding response regulator in two-component regulatory system with TorS Shew_2803 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127511988 Common era GTP-binding protein Era Shew_1055 220 COG1159 Era, GTPase General function prediction only 127512707 Common - alkaline phosphatase Shew_1779 39 None None None 127514443 Common - Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ Shew_3515 27 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 127511398 Nonpathogen - hypothetical protein Shew_0464 1 None None None 127511776 Common - two component transcriptional regulator, LuxR family Shew_0842 223 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 127511904 Common - peptidase C26 Shew_0971 114 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 127513139 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase Shew_2211 123 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 127514199 Common - galactokinase Shew_3271 89 COG0153 GalK, Galactokinase Carbohydrate transport and metabolism 127511583 Nonpathogen - hypothetical protein Shew_0649 1 None None None 127512178 Nonpathogen - hypothetical protein Shew_1246 1 None None None 127511278 Common - Na+/H+ antiporter NhaC Shew_0344 54 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 127512355 Common - hypothetical protein Shew_1426 19 None None None 127511810 Common - methyl-accepting chemotaxis sensory transducer Shew_0876 146 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127512037 Common - prepilin-type cleavage/methylation-like protein Shew_1104 21 COG4966 PilW, Tfp pilus assembly protein PilW Cell motility and secretion / Intracellular trafficking and secretion 127511074 Common - RNP-1-like RNA-binding protein Shew_0140 66 COG0724 COG0724, RNA-binding proteins (RRM domain) General function prediction only 127514369 Common - dephospho-CoA kinase Shew_3441 207 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 127511277 Common - hypothetical protein Shew_0343 6 None None None 127514585 Common - Oligopeptidase A Shew_3657 124 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 127512350 Common - hypothetical protein Shew_1421 1 None None None 127513253 Common - hypothetical protein Shew_2325 97 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 127512505 Common dcd deoxycytidine triphosphate deaminase Shew_1576 155 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 127513723 Common - Xanthine/uracil/vitamin C permease Shew_2795 134 COG2252 COG2252, Permeases General function prediction only 127511955 Common - tyrosyl-tRNA synthetase Shew_1022 240 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 127512069 Common - pyrroline-5-carboxylate reductase Shew_1136 214 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 127513062 Common - heat shock protein Hsp20 Shew_2134 66 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 127513378 Common - hypothetical protein Shew_2450 1 None None None 127511729 Nonpathogen - hypothetical protein Shew_0795 3 None None None 127511210 Common - flavocytochrome c Shew_0276 198 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 127513551 Common - UDP-N-acetylglucosamine acyltransferase Shew_2623 168 COG1043 LpxA, Acyl- acyl carrier protein 127512811 Nonpathogen - hypothetical protein Shew_1883 1 None None None 127513459 Common - transcriptional regulator, LysR family Shew_2531 193 COG0583 LysR, Transcriptional regulator Transcription 127513836 Common - transcriptional regulator, LysR family Shew_2908 102 COG0583 LysR, Transcriptional regulator Transcription 127513588 Common - protein of unknown function DUF214 Shew_2660 129 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 127511370 Common - diguanylate cyclase/phosphodiesterase Shew_0436 162 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 127512256 Common - acetyltransferase-like protein Shew_1325 21 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 127514722 Nonpathogen - hypothetical protein Shew_3794 1 None None None 127512585 Common - 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase Shew_1656 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 127511189 Common - ion transport 2 domain protein Shew_0255 21 None None None 127513011 Common - protein of unknown function DUF785 Shew_2083 32 COG4067 COG4067, Uncharacterized protein conserved in archaea Posttranslational modification, protein turnover, chaperones 127511067 Common - phospholipid/glycerol acyltransferase Shew_0133 170 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 127512238 Common - CMP/dCMP deaminase, zinc-binding Shew_1306 176 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 127513049 Common - diguanylate cyclase Shew_2121 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 127512960 Common - threonyl-tRNA synthetase Shew_2032 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 127511240 Common - diguanylate cyclase/phosphodiesterase with GAF sensor Shew_0306 180 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 127512846 Common - LexA regulated protein Shew_1918 21 None None None 127513285 Common - D,D-heptose 1,7-bisphosphate phosphatase Shew_2357 133 COG0241 HisB, Histidinol phosphatase and related phosphatases Amino acid transport and metabolism 127512360 Common - protein of unknown function DUF583 Shew_1431 48 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 127513899 Common - hypothetical protein Shew_2971 7 None None None 127513617 Common - sulfotransferase Shew_2689 18 None None None 127511606 Common - uroporphyrin-III C-methyltransferase Shew_0672 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 127512643 Common - alpha/beta hydrolase fold Shew_1714 154 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 127513009 Common - putative methyltransferase Shew_2081 51 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 127514681 Common - hypothetical protein Shew_3753 1 None None None 127513979 Common - Cupin 2, conserved barrel domain protein Shew_3051 68 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 127513896 Common - Glutathione S-transferase, N-terminal domain Shew_2968 105 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 127513911 Common - Tat (twin-arginine translocation) pathway signal sequence domain protein Shew_2983 5 None None None 127511182 Common - GCN5-related N-acetyltransferase Shew_0248 127 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 127511920 Nonpathogen - hypothetical protein Shew_0987 1 None None None 127510950 Common - SirA family protein Shew_0015 96 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 127511677 Common - sodium:dicarboxylate symporter Shew_0743 163 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 127511069 Common - selenide, water dikinase Shew_0135 139 COG0709 SelD, Selenophosphate synthase Amino acid transport and metabolism 127513913 Common - Sel1 domain protein repeat-containing protein Shew_2985 21 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 127512224 Common - Tetratricopeptide TPR_4 Shew_1292 58 COG2976 COG2976, Uncharacterized protein conserved in bacteria Function unknown 127513023 Common - phosphomethylpyrimidine kinase Shew_2095 217 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 127512032 Common - isoleucyl-tRNA synthetase Shew_1099 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 127511886 Common - major facilitator superfamily MFS_1 Shew_0953 62 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 127513995 Common - yecA family protein Shew_3067 42 COG3079 COG3079, Uncharacterized protein conserved in bacteria Function unknown 127513852 Common - PhoH family protein Shew_2924 198 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 127512991 Common - Rhomboid family protein Shew_2063 17 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 127511563 Common - extracellular solute-binding protein, family 3 Shew_0629 20 None None None 127514181 Nonpathogen - hypothetical protein Shew_3253 1 None None None 127513905 Common - diguanylate cyclase Shew_2977 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 127514632 Common - dTDP-glucose 4,6-dehydratase Shew_3704 229 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 127513042 Common - Hydroxyacylglutathione hydrolase Shew_2114 199 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 127511184 Common - transcriptional regulator, MerR family Shew_0250 62 COG0789 SoxR, Predicted transcriptional regulators Transcription 127511103 Common rplX 50S ribosomal protein L24 Shew_0169 211 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 127513591 Common - elongation factor G Shew_2663 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 127511627 Nonpathogen - hypothetical protein Shew_0693 1 None None None 127514277 Common - ATP-dependent protease La (LON) domain protein, putative Shew_3349 16 COG2802 COG2802, Uncharacterized protein, similar to the N-terminal domain of Lon protease General function prediction only 127512408 Common - Deoxyribodipyrimidine photo-lyase Shew_1479 134 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 127512522 Common - ribonuclease, Rne/Rng family Shew_1593 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 127514251 Common - lipase-like Shew_3323 30 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 127514777 Common - ATP synthase I chain Shew_3852 33 COG3312 AtpI, F0F1-type ATP synthase, subunit I Energy production and conversion 127513431 Common - short-chain alcohol dehydrogenase Shew_2503 25 COG3007 COG3007, Uncharacterized paraquat-inducible protein B Function unknown 127514085 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Shew_3157 169 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 127514455 Common - GCN5-related N-acetyltransferase Shew_3527 52 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 127511639 Nonpathogen - hypothetical protein Shew_0705 1 None None None 127512592 Common - hypothetical protein Shew_1663 5 None None None 127513382 Common - protein of unknown function DUF45 Shew_2454 46 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 127512480 Common - hypothetical protein Shew_1551 9 COG3816 COG3816, Uncharacterized protein conserved in bacteria Function unknown 127513461 Common - Gluconate transporter Shew_2533 78 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 127514675 Common - hypothetical protein Shew_3747 2 COG4531 ZnuA, ABC-type Zn2+ transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 127511400 Common - acriflavin resistance protein Shew_0466 178 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 127512514 Common - hypothetical protein Shew_1585 3 None None None 127513392 Common - protein of unknown function DUF81 Shew_2464 114 COG0730 COG0730, Predicted permeases General function prediction only 127513589 Common - hypothetical protein Shew_2661 25 None None None 127514017 Common - hypothetical protein Shew_3089 7 None None None 127513909 Common - beta-lactamase domain protein Shew_2981 44 COG2015 COG2015, Alkyl sulfatase and related hydrolases Secondary metabolites biosynthesis, transport, and catabolism 127513889 Nonpathogen - hypothetical protein Shew_2961 1 None None None 127511978 Common - protein of unknown function DUF339 Shew_1045 48 COG2938 COG2938, Uncharacterized conserved protein Function unknown 127511571 Nonpathogen - hypothetical protein Shew_0637 1 None None None 127514117 Common - protein of unknown function UPF0016 Shew_3189 77 COG2119 COG2119, Predicted membrane protein Function unknown 127511647 Common - transport system permease protein Shew_0713 188 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 127511759 Common - ribose-5-phosphate isomerase A Shew_0825 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 127513775 Common proA gamma-glutamyl phosphate reductase Shew_2847 190 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 127513923 Common - TonB family protein Shew_2995 56 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 127512669 Common - nitroreductase Shew_1740 80 COG0778 NfnB, Nitroreductase Energy production and conversion 127512997 Common - electron transport complex, RnfABCDGE type, D subunit Shew_2069 76 COG4658 RnfD, Predicted NADH:ubiquinone oxidoreductase, subunit RnfD Energy production and conversion 127514411 Common dut deoxyuridine 5'-triphosphate nucleotidohydrolase Shew_3483 179 COG0756 Dut, dUTPase Nucleotide transport and metabolism 127513578 Common - hypothetical protein Shew_2650 5 COG2913 SmpA, Small protein A (tmRNA-binding) Translation, ribosomal structure and biogenesis 127514464 Common - hypothetical protein Shew_3536 21 None None None 127514656 Common - globin Shew_3728 68 COG2346 COG2346, Truncated hemoglobins General function prediction only 127512301 Common - flagellar export protein FliJ Shew_1370 4 COG2882 FliJ, Flagellar biosynthesis chaperone Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 127512736 Common - hypothetical protein Shew_1808 62 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 127512282 Common flgH flagellar basal body L-ring protein Shew_1351 101 COG2063 FlgH, Flagellar basal body L-ring protein Cell motility and secretion 127512316 Common - chemotaxis phosphatase, CheZ Shew_1385 46 COG3143 CheZ, Chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127512650 Common - Methyltransferase type 11 Shew_1721 138 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 127511040 Common - predicted gluconate transport-associated protein Shew_0106 81 COG0694 COG0694, Thioredoxin-like proteins and domains Posttranslational modification, protein turnover, chaperones 127512983 Common - hypothetical protein Shew_2055 1 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 127511054 Common - hypothetical protein Shew_0120 37 COG3346 COG3346, Uncharacterized conserved protein Function unknown 127512513 Common - nucleoside recognition domain protein Shew_1584 39 COG2715 SpmA, Uncharacterized membrane protein, required for spore maturation in B.subtilis. General function prediction only 127512735 Common - BNR repeat protein Shew_1807 34 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 127511444 Common - putative outer membrane adhesin like proteiin Shew_0510 93 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 162139868 Common - aconitate hydratase Shew_1822 223 COG1048 AcnA, Aconitase A Energy production and conversion 127511476 Common - hypothetical protein Shew_0542 22 COG5345 COG5345, Uncharacterized protein conserved in bacteria Function unknown 127513880 Common - methyl-accepting chemotaxis sensory transducer Shew_2952 146 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 127511264 Common - putative TIM-barrel protein, nifR3 family Shew_0330 209 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 127514739 Common - protein of unknown function UPF0153 Shew_3811 36 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 127512225 Common - outer membrane protein assembly complex subunit YfgL Shew_1293 119 COG1520 COG1520, FOG: WD40-like repeat Function unknown 127512077 Common - protein of unknown function DUF179 Shew_1144 130 COG1678 COG1678, Putative transcriptional regulator Transcription 127511775 Common - uncharacterized conserved protein UCP006287 Shew_0841 22 COG3112 COG3112, Uncharacterized protein conserved in bacteria Function unknown 127513518 Common - transferase hexapeptide repeat containing protein Shew_2590 211 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 127514786 Common - hypothetical protein Shew_3861 5 None None None 127511709 Common - transcriptional regulator, TetR family Shew_0775 23 COG1309 AcrR, Transcriptional regulator Transcription 127513450 Common - decaheme cytochrome c Shew_2522 8 None None None 127512870 Common - NADH:flavin oxidoreductase/NADH oxidase Shew_1942 199 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 127511736 Common - chromate transporter, chromate ion transporter (CHR) family Shew_0802 69 COG2059 ChrA, Chromate transport protein ChrA Inorganic ion transport and metabolism 127512070 Common - alanine racemase domain protein Shew_1137 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 127511735 Common rumB 23S rRNA metyluridine methyltransferase Shew_0801 183 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 127513102 Common - fatty acid metabolism regulator Shew_2174 88 COG2186 FadR, Transcriptional regulators Transcription 127511320 Common - Fimbrial assembly family protein Shew_0386 5 COG3166 PilN, Tfp pilus assembly protein PilN Cell motility and secretion / Intracellular trafficking and secretion 127513394 Common - hypothetical protein Shew_2466 5 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 127513842 Common - outer membrane lipoprotein LolB Shew_2914 41 COG3017 LolB, Outer membrane lipoprotein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 127512962 Common - short-chain dehydrogenase/reductase SDR Shew_2034 233 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 127512955 Common - alanine dehydrogenase/PNT domain protein Shew_2027 164 COG0686 Ald, Alanine dehydrogenase Amino acid transport and metabolism 127512363 Common - UTP-glucose-1-phosphate uridylyltransferase GalU Shew_1434 231 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 127512850 Common - phosphoglucomutase Shew_1922 176 COG0033 Pgm, Phosphoglucomutase Carbohydrate transport and metabolism 127512311 Common flhA flagellar biosynthesis protein A Shew_1380 127 COG1298 FlhA, Flagellar biosynthesis pathway, component FlhA Cell motility and secretion / Intracellular trafficking and secretion 127511802 Common - Trans-hexaprenyltranstransferase Shew_0868 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 127512263 Common - short-chain dehydrogenase/reductase SDR Shew_1332 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 127514570 Common - hypothetical protein Shew_3642 6 None None None 127512524 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Shew_1595 194 COG0546 Gph, Predicted phosphatases General function prediction only 127511548 Common - cysteine/glutathione ABC transporter membrane/ATP-binding component Shew_0614 249 COG4987 CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 127512883 Common - integration host factor, beta subunit Shew_1955 206 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 127512746 Common - conserved hypothetical ATP-dependent protease Shew_1818 118 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 127514216 Common - 23S rRNA (guanosine-2'-O-)-methyltransferase Shew_3288 215 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 127513283 Common - hypothetical protein Shew_2355 12 COG3110 COG3110, Uncharacterized protein conserved in bacteria Function unknown 127512617 Common - TonB-dependent receptor Shew_1688 121 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 127514166 Nonpathogen - hypothetical protein Shew_3238 1 None None None 127514639 Common - Rhodanese domain protein Shew_3711 129 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 127512244 Common - transcriptional regulator, TetR family Shew_1313 122 COG1309 AcrR, Transcriptional regulator Transcription 127511138 Common - ornithine carbamoyltransferase Shew_0204 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 127511840 Common - PAS/PAC sensor hybrid histidine kinase Shew_0907 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127513610 Common - hypothetical protein Shew_2682 17 None None None 127512288 Common - flagellin domain protein Shew_1357 123 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 127512169 Nonpathogen - hypothetical protein Shew_1237 1 None None None 127514563 Common - thiamine pyrophosphate enzyme domain protein TPP-binding Shew_3635 144 COG3961 COG3961, Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only 127511382 Common - periplasmic solute binding protein Shew_0448 95 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 127514547 Common - general secretion pathway protein D Shew_3619 137 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 127513267 Common - protein of unknown function DUF479 Shew_2339 33 COG3124 COG3124, Uncharacterized protein conserved in bacteria Function unknown 127514139 Common - Glutathione S-transferase, C-terminal domain Shew_3211 103 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 127512807 Common - GCN5-related N-acetyltransferase Shew_1879 31 COG0456 RimI, Acetyltransferases General function prediction only 127513541 Common - integral membrane sensor hybrid histidine kinase Shew_2613 220 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 127512318 Common - chemotaxis-specific methylesterase Shew_1387 215 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 127513449 Common - decaheme cytochrome c MtrF Shew_2521 8 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 127513193 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Shew_2265 104 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 127512969 Common - protein of unknown function DUF1705 Shew_2041 61 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 127510961 Common - hypothetical protein Shew_0026 21 COG0824 FcbC, Predicted thioesterase General function prediction only 127512607 Nonpathogen - hypothetical protein Shew_1678 2 None None None 127514093 Common - polar amino acid ABC transporter, inner membrane subunit Shew_3165 175 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 127511168 Common - protein of unknown function DUF1232 Shew_0234 40 COG3339 COG3339, Uncharacterized conserved protein Function unknown 127511635 Nonpathogen - hypothetical protein Shew_0701 2 None None None 127513349 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Shew_2421 196 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 127514622 Common - ADP-L-glycero-D-manno-heptose-6-epimerase Shew_3694 228 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 127511158 Common - transport-associated Shew_0224 60 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 127511659 Common - protein of unknown function DUF214 Shew_0725 17 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 127511000 Common - formate dehydrogenase, gamma subunit Shew_0065 65 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 127512493 Common - cold-shock DNA-binding domain protein Shew_1564 177 COG1278 CspC, Cold shock proteins Transcription 127513808 Common - Na(+)-translocating NADH-quinone reductase subunit B Shew_2880 76 COG1805 NqrB, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB Energy production and conversion 127511767 Common - hypoxanthine-guanine phosphoribosyltransferase Shew_0833 42 COG2236 COG2236, Predicted phosphoribosyltransferases General function prediction only 127514326 Common - cytochrome c, class I Shew_3398 66 COG2863 COG2863, Cytochrome c553 Energy production and conversion 127512998 Common - electron transport complex protein RnfG Shew_2070 57 COG4659 RnfG, Predicted NADH:ubiquinone oxidoreductase, subunit RnfG Energy production and conversion 127512183 Common - hypothetical protein Shew_1251 1 None None None 127513044 Common - AsmA family protein Shew_2116 69 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 127513463 Common - Pyridoxal-dependent decarboxylase Shew_2535 122 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 127513185 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Shew_2257 36 COG0546 Gph, Predicted phosphatases General function prediction only 127511031 Common - two component transcriptional regulator, winged helix family Shew_0097 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127513308 Common - putative sulfate transport protein CysZ Shew_2380 44 COG2981 CysZ, Uncharacterized protein involved in cysteine biosynthesis Amino acid transport and metabolism 127512677 Nonpathogen - hypothetical protein Shew_1748 1 None None None 127512164 Nonpathogen - hypothetical protein Shew_1232 1 None None None 127514704 Common - AMP-dependent synthetase and ligase Shew_3776 213 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 127511598 Common - alanine dehydrogenase/PNT domain protein Shew_0664 166 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 127511192 Common - hypothetical protein Shew_0258 1 None None None 127513159 Common - thioredoxin domain protein Shew_2231 125 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 127512842 Common - aminotransferase AlaT Shew_1914 237 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 127512844 Common - hypothetical protein Shew_1916 23 COG4394 COG4394, Uncharacterized protein conserved in bacteria Function unknown 127514446 Common - thioesterase superfamily protein Shew_3518 62 COG0824 FcbC, Predicted thioesterase General function prediction only 127513940 Common - MscS Mechanosensitive ion channel Shew_3012 226 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 127513477 Common - NAD(P)H dehydrogenase (quinone) Shew_2549 73 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 127512024 Common - putative phosphoketolase Shew_1091 67 COG3957 COG3957, Phosphoketolase Carbohydrate transport and metabolism 127513784 Common - ThiJ/PfpI domain protein Shew_2856 15 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 127514757 Common - transposase IS3/IS911 family protein Shew_3829 30 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 127512507 Common - aminodeoxychorismate lyase Shew_1578 185 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 127513126 Common - Histidinol dehydrogenase Shew_2198 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 127513511 Common - electron transfer flavoprotein, alpha subunit Shew_2583 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 127513521 Common - acyl-CoA synthetase Shew_2593 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127511556 Common - hypothetical protein Shew_0622 4 None None None 127512728 Common - putative GAF sensor protein Shew_1800 81 COG1956 COG1956, GAF domain-containing protein Signal transduction mechanisms 127512409 Common - protein of unknown function DUF1486 Shew_1480 29 None None None 127512446 Common - putative adenylyl cyclase CyaB Shew_1517 16 COG1437 CyaB, Adenylate cyclase, class 2 (thermophilic) Nucleotide transport and metabolism 127511787 Common - ABC transporter-related protein Shew_0853 249 COG5265 ATM1, ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components Posttranslational modification, protein turnover, chaperones 127512891 Nonpathogen - hypothetical protein Shew_1963 1 None None None 127514240 Common - sigma 54 modulation protein/ribosomal protein S30EA Shew_3312 131 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 127514286 Common - outer membrane efflux family protein, putative Shew_3358 12 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 127512717 Common - cystathionine beta-lyase Shew_1789 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 127514360 Common pdhR transcriptional regulator PdhR Shew_3432 144 COG2186 FadR, Transcriptional regulators Transcription 127514732 Common - preprotein translocase subunit SecB Shew_3804 108 COG1952 SecB, Preprotein translocase subunit SecB Intracellular trafficking and secretion 127512390 Common - zinc carboxypeptidase-related protein Shew_1461 11 COG3608 COG3608, Predicted deacylase General function prediction only 127514312 Common ubiA 4-hydroxybenzoate octaprenyltransferase Shew_3384 196 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 127511453 Common - transcriptional repressor protein MetJ Shew_0519 23 COG3060 MetJ, Transcriptional regulator of met regulon Transcription / Amino acid transport and metabolism 127511917 Common - beta-lactamase Shew_0984 56 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 127513686 Common - hypothetical protein Shew_2758 22 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 127511794 Common - hypothetical protein Shew_0860 2 None None None 127514584 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Shew_3656 14 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 127511524 Common - hypothetical protein Shew_0590 1 None None None 127511139 Common - argininosuccinate synthase Shew_0205 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 127513801 Common - bacterioferritin Shew_2873 98 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 127514693 Common - hypothetical protein Shew_3765 8 None None None 127511531 Common - major facilitator superfamily MFS_1 Shew_0597 48 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 127513413 Common - primosomal replication protein N'', putative Shew_2485 5 COG3923 PriC, Primosomal replication protein N'' DNA replication, recombination, and repair 127512829 Common - hypothetical protein Shew_1901 3 None None None 127512933 Common - FAD dependent oxidoreductase Shew_2005 115 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 127514134 Common - periplasmic nitrate reductase, large subunit Shew_3206 183 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 127514331 Common - ABC-2 type transporter Shew_3403 34 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 127512602 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase Shew_1673 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 127513166 Common - hypothetical protein Shew_2238 2 None None None 127513056 Common - transglutaminase domain protein Shew_2128 93 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 127511293 Common fre FMN reductase Shew_0359 99 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 127512106 Common - sulfotransferase Shew_1174 41 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 127513419 Common - Methionine gamma-lyase Shew_2491 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 127512059 Common - glutaminase Shew_1126 72 COG2066 GlsA, Glutaminase Amino acid transport and metabolism 127511613 Common - hypothetical protein Shew_0679 5 None None None 127513718 Common - nucleoside recognition domain protein Shew_2790 20 COG3314 COG3314, Uncharacterized protein conserved in bacteria Function unknown 127512898 Common - histidine kinase Shew_1970 219 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 127513638 Common - O-acetylhomoserine/O-acetylserine sulfhydrylase Shew_2710 206 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 127511105 Common rpsN 30S ribosomal protein S14 Shew_0171 207 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 127511318 Common - regulatory protein CsrD Shew_0384 158 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 127511783 Common - TPR repeat-containing protein Shew_0849 14 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 127514372 Common - mutator MutT protein Shew_3444 174 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 127513753 Common - tRNA pseudouridine synthase B Shew_2825 245 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 127514743 Common - hypothetical protein Shew_3815 24 COG3205 COG3205, Predicted membrane protein Function unknown 127512345 Common - glycosyl transferase, family 2 Shew_1414 112 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 127512011 Common - peptidylprolyl isomerase, FKBP-type Shew_1078 114 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 127514075 Nonpathogen - hypothetical protein Shew_3147 1 None None None 127513711 Common - peptidase U32 Shew_2783 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 127513631 Common - Sel1 domain protein repeat-containing protein Shew_2703 106 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 127511360 Common - ABC transporter-related protein Shew_0426 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 127511894 Common - hypothetical protein Shew_0961 1 None None None 127513988 Common - hypothetical protein Shew_3060 96 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 127514054 Common - 2'-5' RNA ligase Shew_3126 50 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 127513002 Common - TonB-dependent receptor Shew_2074 114 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 127511228 Common - Alanine--glyoxylate transaminase Shew_0294 166 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 127513280 Nonpathogen - hypothetical protein Shew_2352 1 None None None 127511461 Common - Sel1 domain protein repeat-containing protein Shew_0527 70 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 127514030 Common - hypothetical protein Shew_3102 18 None None None 127511477 Common - hypothetical protein Shew_0543 17 None None None 127514767 Common - UDP-N-acetylglucosamine pyrophosphorylase Shew_3842 233 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 127511086 Common - DNA-directed RNA polymerase subunit beta' Shew_0152 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 127511664 Common - protein of unknown function DUF395, YeeE/YedE Shew_0730 49 COG2391 COG2391, Predicted transporter component General function prediction only 127513990 Common - glycine dehydrogenase Shew_3062 172 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 127514222 Common rplM 50S ribosomal protein L13 Shew_3294 238 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 127513374 Common - GTP cyclohydrolase II Shew_2446 191 COG0807 RibA, GTP cyclohydrolase II Coenzyme metabolism 127513207 Common - tetraheme cytochrome c Shew_2279 6 None None None 127513997 Common - 5-formyltetrahydrofolate cyclo-ligase Shew_3069 184 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 127513963 Common - hypothetical protein Shew_3035 4 None None None 127513340 Common - tRNA/rRNA methyltransferase (SpoU) Shew_2412 21 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 127511018 Common - hypothetical protein Shew_0084 25 COG3296 COG3296, Uncharacterized protein conserved in bacteria Function unknown 127512721 Common - Vault protein inter-alpha-trypsin domain protein Shew_1793 50 COG2304 COG2304, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 127513080 Common - hypothetical protein Shew_2152 5 None None None 127511151 Common - hypothetical protein Shew_0217 2 None None None 127514036 Nonpathogen - hypothetical protein Shew_3108 1 None None None 127513667 Common - Fmu (Sun) domain protein Shew_2739 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 127511541 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Shew_0607 166 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 127512418 Common - hypothetical protein Shew_1489 20 COG3102 COG3102, Uncharacterized protein conserved in bacteria Function unknown 127513954 Common - hypothetical protein Shew_3026 4 None None None 127512745 Common - 3-hydroxydecanoyl-(acyl carrier protein) dehydratase Shew_1817 84 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 127511487 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Shew_0553 222 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 127513557 Common - 1-deoxy-D-xylulose 5-phosphate reductoisomerase Shew_2629 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 127511940 Common - major outer membrane lipoprotein, putative Shew_1007 6 COG4238 COG4238, Murein lipoprotein Cell envelope biogenesis, outer membrane 127513605 Common - putative electron transfer flavoprotein FixA Shew_2677 153 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 127513328 Common - domain of unknown function DUF1731 Shew_2400 105 COG1090 COG1090, Predicted nucleoside-diphosphate sugar epimerase General function prediction only 127510990 Common - hypothetical protein Shew_0055 14 None None None 127513071 Common - hypothetical protein Shew_2143 5 None None None 127511470 Common - tRNA-dihydrouridine synthase A Shew_0536 208 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 127511936 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Shew_1003 84 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 127512919 Common - cytochrome oxidase maturation protein, cbb3-type Shew_1991 20 COG3197 FixS, Uncharacterized protein, possibly involved in nitrogen fixation Inorganic ion transport and metabolism 127513421 Common - protein of unknown function DUF463, YcjX family protein Shew_2493 42 COG3106 COG3106, Predicted ATPase General function prediction only 127513204 Common - glutathione S-transferase Shew_2276 79 COG0435 ECM4, Predicted glutathione S-transferase Posttranslational modification, protein turnover, chaperones 127513827 Common - glutathione synthetase Shew_2899 138 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 127512420 Common - Ion transport protein Shew_1491 95 COG1226 Kch, Kef-type K+ transport systems, predicted NAD-binding component Inorganic ion transport and metabolism 127513412 Common - protein of unknown function DUF81 Shew_2484 110 COG0730 COG0730, Predicted permeases General function prediction only 127514760 Common - conserved hypothetical ISPpu15, transposase Orf2 Shew_3835 3 None None None 127511459 Common - hypothetical protein Shew_0525 4 None None None 127514559 Common - hypothetical protein Shew_3631 1 None None None 127514505 Common - RNA methyltransferase, TrmH family, group 2 Shew_3577 157 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 127512853 Common - 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) Shew_1925 157 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 127512438 Common asnB asparagine synthetase B Shew_1509 155 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 127511698 Common - Radical SAM domain protein Shew_0764 15 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 127512466 Common - FAD dependent oxidoreductase Shew_1537 116 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 127513949 Common - Endonuclease I Shew_3021 32 COG2356 EndA, Endonuclease I DNA replication, recombination, and repair 127514593 Common - Succinylglutamate desuccinylase/aspartoacylase Shew_3665 54 COG3608 COG3608, Predicted deacylase General function prediction only 127513623 Common - two component transcriptional regulator, winged helix family Shew_2695 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 127513078 Nonpathogen - integral membrane protein TerC Shew_2150 1 None None None 127513316 Common - formate/nitrite transporter Shew_2388 111 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 127513644 Common - peptidase S41 Shew_2716 34 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 127514577 Common - hypothetical protein Shew_3649 15 COG4994 COG4994, Uncharacterized protein conserved in bacteria Function unknown 127514328 Common - nitrous-oxide reductase Shew_3400 39 COG4263 NosZ, Nitrous oxide reductase Energy production and conversion 127513868 Common - hypothetical protein Shew_2940 42 COG2921 COG2921, Uncharacterized conserved protein Function unknown 127511851 Common - decaheme cytochrome c Shew_0918 7 None None None 127511873 Common - permease YjgP/YjgQ family protein Shew_0940 124 COG0795 COG0795, Predicted permeases General function prediction only 127512838 Common - iron-containing alcohol dehydrogenase Shew_1910 175 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 127514149 Common - hypothetical protein Shew_3221 7 COG2039 Pcp, Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase) Posttranslational modification, protein turnover, chaperones 127513838 Nonpathogen - hypothetical protein Shew_2910 1 None None None 127511304 Common - protoheme IX farnesyltransferase Shew_0370 166 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 127514144 Common - hypothetical protein Shew_3216 32 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 127511868 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Shew_0935 62 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 127513096 Common - uncharacterized conserved protein UCP025560 Shew_2168 25 COG3784 COG3784, Uncharacterized protein conserved in bacteria Function unknown 127513336 Common - hypothetical protein Shew_2408 13 None None None 127512670 Common - beta-lactamase domain protein Shew_1741 44 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 127514698 Common - Sel1 domain protein repeat-containing protein Shew_3770 83 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 127514605 Common - isochorismate synthase Shew_3677 222 COG1169 MenF, Isochorismate synthase Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127511024 Common - molybdopterin converting factor, subunit 1 Shew_0090 73 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 127513700 Common - GrpE protein Shew_2772 227 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 127513707 Common - conserved hypothetical amino acid ABC transporter Shew_2779 8 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 127514281 Common - conserved hypothetical protein 22 Shew_3353 33 COG2731 EbgC, Beta-galactosidase, beta subunit Carbohydrate transport and metabolism 127514039 Common - NAD-dependent epimerase/dehydratase Shew_3111 98 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 127514388 Common - cell division protein FtsL Shew_3460 37 COG3116 FtsL, Cell division protein Cell division and chromosome partitioning 127511431 Common - putative sulfate transporter YchM Shew_0497 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 127511020 Common - Electron-transferring-flavoprotein dehydrogenase Shew_0086 106 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 127513681 Common - Tetratricopeptide TPR_2 repeat protein Shew_2753 23 None None None 127511839 Nonpathogen - Hpt protein Shew_0906 4 COG2198 ArcB, FOG: HPt domain Signal transduction mechanisms 127514651 Common - alpha/beta hydrolase fold Shew_3723 86 COG2267 PldB, Lysophospholipase Lipid metabolism 127512044 Common - transcriptional regulator, LacI family Shew_1111 128 COG1609 PurR, Transcriptional regulators Transcription 127510998 Common - molybdopterin oxidoreductase Shew_0063 190 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 127510968 Common - peptidase M14, carboxypeptidase A Shew_0033 20 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 127513695 Common motB flagellar motor protein MotB Shew_2767 110 COG1360 MotB, Flagellar motor protein Cell motility and secretion 127512575 Common - beta-lactamase domain protein Shew_1646 48 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 127513493 Nonpathogen - hypothetical protein Shew_2565 3 None None None 127512475 Common - thioesterase superfamily protein Shew_1546 129 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 127511832 Common - transcriptional regulator, LysR family Shew_0899 125 COG0583 LysR, Transcriptional regulator Transcription 127511483 Common - DNA topoisomerase IV subunit B Shew_0549 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 127514114 Common - transcriptional regulator, AraC family Shew_3186 137 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 127513270 Common - integral membrane sensor signal transduction histidine kinase Shew_2342 216 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 127513530 Nonpathogen - hypothetical protein Shew_2602 1 None None None 127514684 Common - histidine ammonia-lyase Shew_3756 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 127511963 Nonpathogen - hypothetical protein Shew_1030 1 None None None 127512533 Common - acyl carrier protein Shew_1604 176 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 127514265 Common - protein of unknown function DUF6, transmembrane Shew_3337 60 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 127514290 Common - hypothetical protein Shew_3362 113 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 127511843 Common - hypothetical protein Shew_0910 23 COG3615 TehB, Uncharacterized protein/domain, possibly involved in tellurite resistance Inorganic ion transport and metabolism 127513650 Common - hypothetical protein Shew_2722 6 COG2384 COG2384, Predicted SAM-dependent methyltransferase General function prediction only 127513675 Common - phosphate binding protein Shew_2747 110 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 127513945 Common - glycerophosphoryl diester phosphodiesterase Shew_3017 49 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 127513936 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Shew_3008 130 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 127514538 Common - General secretion pathway M protein Shew_3610 20 COG3149 PulM, Type II secretory pathway, component PulM Intracellular trafficking and secretion 127514522 Common - hypothetical protein Shew_3594 3 None None None