Clostridium difficile 630, complete genome NC_009089 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 126700980 Common - two-component system response regulator CD3360 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126698890 Common - AraC-family transcriptional regulator CD1293 131 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 126698414 Common - putative isocitrate/3-isopropylmalate dehydrogenase CD0834 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 126698076 Common orf20 putative conjugative transposon replication initiation factor CD0499 8 COG2946 COG2946, Putative phage replication protein RstA DNA replication, recombination, and repair 126699980 Common - putative sulfonate ABC transporter,solute-binding lipoprotein CD2365 85 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 126701036 Common - putative nucleotide pyrophosphatase CD3413 35 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 126700150 Common - ABC transporter, permease protein CD2533 43 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126697780 Common - putative sugar-phosphate kinase CD0209 20 COG4573 GatZ, Predicted tagatose 6-phosphate kinase Carbohydrate transport and metabolism 126700177 Common - hypothetical protein CD2559 217 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 126700112 Common selD selenide,water dikinase CD2496 147 COG0709 SelD, Selenophosphate synthase Amino acid transport and metabolism 126699041 Common - putative sigma-54-dependent transcriptional regulator (partial) CD1437 14 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 126698133 Common sip2 signal peptidase I CD0554 179 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 126698442 Common - hypothetical protein CD0865 103 COG2110 COG2110, Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 General function prediction only 126698064 Common - putative carbon-nitrogen hydrolase CD0487 206 COG0388 COG0388, Predicted amidohydrolase General function prediction only 126700841 Common - putative amidohydrolase CD3221 165 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 126698728 Common gloA lactoylglutathione lyase CD1134 100 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 126700970 Common - putative glycosyl transferase CD3350 59 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 126697714 Common - putative RNA-binding protein CD0142 105 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 126698454 Common - ABC transporter, ATP-binding protein CD0877 249 COG1101 PhnK, ABC-type uncharacterized transport system, ATPase component General function prediction only 126698071 Common - PTS system, IId component CD0494 40 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 126701299 Common spo0J stage 0 sporulation protein J CD3671 185 COG1475 Spo0J, Predicted transcriptional regulators Transcription 126698090 Common orf7 putative conjugative transposon regulatory protein CD0510 8 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 126698045 Common - PTS system, IIabc component CD0469 60 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 126700834 Common - putative osmoprotectant acid ABC transporter,ATP-binding protein CD3215 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 126698127 Common - putative penicillin-binding protein CD0548 25 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 126700897 Common - PTS system, IIa component CD3278 71 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 126698225 Common - conserved hypothetical protein (partial) CD0647 29 COG3177 COG3177, Uncharacterized conserved protein Function unknown 126699648 Common argM succinylornithine transaminase CD2031 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 126698183 Common - hypothetical protein CD0605 26 COG2320 GrpB, Uncharacterized conserved protein Function unknown 126701302 Common gidA tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA CD3675 193 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 126700199 Common - radical SAM protein CD2580 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 126700447 Common - putative collagen-binding protein CD2831 11 COG4932 COG4932, Predicted outer membrane protein Cell envelope biogenesis, outer membrane 126700225 Common mtnN 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase CD2611 99 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 126697659 Common rplO 50S ribosomal protein L15 CD0089 215 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 126700871 Common - hypothetical protein CD3252 7 None None None 126698812 Common - hypothetical protein CD1216 9 None None None 126699131 Common - ABC transporter, permease protein CD1527 207 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 126700572 Common - ABC transporter, substrate-binding protein CD2953 114 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 126698246 Common cdd4 putative lantibiotic ABC transporter,ATP-binding protein CD0667 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126699684 Common - hypothetical protein CD2067 2 None None None 126700581 Common - hypothetical protein CD2961 5 None None None 126698721 Common - hypothetical protein CD1127 3 None None None 126698802 Common - hypothetical protein CD1206 28 COG1963 COG1963, Uncharacterized protein conserved in bacteria Function unknown 126699426 Common ispH 4-hydroxy-3-methylbut-2-enyl diphosphate reductase CD1818 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 126700040 Common - phosphate butyryltransferase CD2425 142 COG0280 Pta, Phosphotransacetylase Energy production and conversion 126700094 Common - hypothetical protein CD2477 25 COG4866 COG4866, Uncharacterized conserved protein Function unknown 126700274 Common - probable peptidase CD2660 178 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 126700561 Common - putative phage replication protein CD2943 7 COG3935 DnaD, Putative primosome component and related proteins DNA replication, recombination, and repair 126699503 Common - putative regulatory protein CD1893 29 COG3760 COG3760, Uncharacterized conserved protein Function unknown 126700577 Common ntpC V-type ATP synthase subunit C CD2957 28 COG1527 NtpC, Archaeal/vacuolar-type H+-ATPase subunit C Energy production and conversion 126699693 Common - hypothetical protein CD2076 165 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 126698256 Common - putative RNA polymerase sigma factor CD0677 139 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 126698623 Common - hypothetical protein CD1039 9 None None None 126697648 Common rpmC 50S ribosomal protein L29 CD0080A 169 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 126700124 Common - AraC-family transcriptional regulator CD2508 28 COG2169 Ada, Adenosine deaminase Nucleotide transport and metabolism 126699382 Common - hypothetical protein CD1773 4 None None None 126700692 Common tagT PTS system, IIabc component CD3075 125 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 126697734 Pathogen - hypothetical protein CD0163A 1 None None None 126698977 Pathogen - hypothetical protein CD1376 1 None None None 126700597 Common - hypothetical protein CD2976 95 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 126697650 Common rplN 50S ribosomal protein L14 CD0082 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 126699641 Common - ABC transporter, ATP-binding protein CD2024 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126700798 Common - D-hydantoinase CD3178 203 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 126699931 Common - ABC transporter, ATP-binding protein CD2313 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 126699564 Common - ABC transporter, ATP-binding protein CD1955 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126699913 Common - putative phage-related regulatory protein CD2297 34 COG3617 COG3617, Prophage antirepressor Transcription 126700244 Common glyC glycerol-3-phosphate dehydrogenase (NAD(P)+) CD2630 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 126700794 Common gapB glyceraldehyde-3-phosphate dehydrogenase 2 CD3174 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 126698974 Common - putative phage tail fiber protein CD1373 23 COG5301 COG5301, Phage-related tail fibre protein General function prediction only 126699387 Common - hypothetical protein CD1778 6 None None None 126699625 Pathogen - conserved plasmid hypothetical protein CD2009A 1 None None None 126700777 Common - hypothetical protein CD3158 68 COG2013 COG2013, Uncharacterized conserved protein Function unknown 126700758 Pathogen - hypothetical protein CD3140 1 None None None 126699942 Common gatD putative galactitol-1-phosphate 5-dehydrogenase CD2324 211 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 126699614 Pathogen - hypothetical protein CD2002A 1 None None None 126700108 Common pmi mannose-6-phosphate isomerase CD2491 51 COG1482 ManA, Phosphomannose isomerase Carbohydrate transport and metabolism 126697831 Pathogen - putative flagellar protein CD0259 1 None None None 126699949 Common mtlD mannitol-1-phosphate 5-dehydrogenase CD2331 81 COG0246 MtlD, Mannitol-1-phosphate/altronate dehydrogenases Carbohydrate transport and metabolism 126699800 Common - N-acetylmuramoyl-L-alanine amidase (cell wall hydrolase) (partial) region relative to most database matches. CD2184 10 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 126700966 Common - conjugative transposon conserved hypothetical protein CD3346 6 None None None 126699312 Common thiH thiamine biosynthesis protein ThiH CD1705 59 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 126700903 Common - probable protease CD3284 223 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 126700450 Common glyA serine hydroxymethyltransferase CD2834 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 126698885 Common - putative membrane-bound metal-dependent hydrolase CD1288 2 None None None 126700147 Common - hypothetical protein CD2530 20 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 126701072 Common agaS putative tagatose-6-phosphate ketose/aldose isomerase CD3449 31 COG2222 AgaS, Predicted phosphosugar isomerases Cell envelope biogenesis, outer membrane 126698015 Common rocR putative arginine utilization sigma-54 dependent regulatory protein CD0441 169 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 126697723 Common rimI putative ribosomal-protein-alanine acetyltransferase CD0151 171 COG0456 RimI, Acetyltransferases General function prediction only 126699411 Common - putative hydrolase CD1802 19 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 126699024 Common - putative signaling protein CD1419 192 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126700894 Common - putative phosphosugar isomerase CD3275 199 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 126699578 Common - putative regulatory protein CD1969 37 COG3760 COG3760, Uncharacterized conserved protein Function unknown 126697641 Common rplD 50S ribosomal protein L4 CD0074 217 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 126698574 Common leuC 3-isopropylmalate dehydratase large subunit CD0990 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 126697709 Common - PTS system, IIc component CD0137 38 COG1455 CelB, Phosphotransferase system cellobiose-specific component IIC Carbohydrate transport and metabolism 126699016 Common - hypothetical protein CD1413 157 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 126700674 Common - putative proton/sugar symporter CD3057 3 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 126698809 Common spoIVB stage IV sporulation protein B CD1213 17 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 126700409 Common slpA cell surface protein (S-layer precursor protein) CD2793 6 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126697947 Pathogen - conjugative tansposon protein CD0377 5 None None None 126699582 Common - hypothetical protein CD1973 38 COG4100 COG4100, Cystathionine beta-lyase family protein involved in aluminum resistance Inorganic ion transport and metabolism 126700402 Common - cell surface protein CD2786 10 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126699585 Common mutL DNA mismatch repair protein CD1976 191 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 126700084 Common lepA GTP-binding protein LepA CD2467 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 126700995 Common mgtB magnesium transporting ATPase, P-type CD3373 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 126697875 Common argE putative acetylornithine deacetylase CD0303 207 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 126699671 Common lysC aspartokinase CD2054 234 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 126701040 Common - ABC transporter, ATP-binding protein CD3417 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 126698216 Common - hypothetical protein CD0638 5 None None None 126701292 Common - putative amino acid aminotransferase CD3664 225 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 126699888 Common - hypothetical protein CD2273 83 COG0628 PerM, Predicted permease General function prediction only 126699352 Common - putative ferrous iron transport protein A CD1745A 55 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 126699777 Pathogen - hypothetical protein CD2161 1 None None None 126700482 Common - putative regulatory protease CD2866 159 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 126701276 Common - hypothetical protein CD3649 166 COG1576 COG1576, Uncharacterized conserved protein Function unknown 126701145 Common - putative peptidase CD3521 103 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 126700054 Common cdd cytidine deaminase CD2438 117 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 126699196 Common kdpB potassium-transporting ATPase subunit B CD1592 232 COG2216 KdpB, High-affinity K+ transport system, ATPase chain B Inorganic ion transport and metabolism 126699485 Common vexP1 ABC transporter, permease protein CD1873 10 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126699633 Pathogen - hypothetical protein CD2016 1 None None None 126698085 Pathogen orf12 tet(M) leader peptide CD0507A 1 None None None 126697916 Common - metallo-beta-lactamase superfamily protein CD0344 65 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 126699724 Common - putative xanthine/uracil permease CD2107 134 COG2252 COG2252, Permeases General function prediction only 126699320 Common moaA molybdenum cofactor biosynthesis protein CD1713 211 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 126697860 Common - PTS system, IIc component CD0288 37 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 126697666 Common rpsM 30S ribosomal protein S13 CD0095 248 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 126699655 Common - putative drug/sodium antiporter CD2038 123 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 126699341 Common - hypothetical protein CD1734 4 None None None 126698231 Common - ABC transporter, ATP-binding protein CD0653 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126699606 Common - hypothetical protein CD1995 112 COG0730 COG0730, Predicted permeases General function prediction only 126700848 Common - hypothetical protein CD3228 35 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 126699762 Common - DNA mismatch repair protein CD2145 201 COG1193 COG1193, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 126699345 Common - two-component sensor histidine kinase CD1738 226 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 126699728 Common - DeoR-family transcriptional regulator CD2111 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 126697677 Common cwlD germination-specific N-acetylmuramoyl-L-alanine amidase CD0106 177 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 126701260 Common - MerR-family transcriptional regulator CD3634 16 COG0789 SoxR, Predicted transcriptional regulators Transcription 126698209 Common - hypothetical protein CD0631 17 COG1695 COG1695, Predicted transcriptional regulators Transcription 126699327 Common - hypothetical protein CD1721 33 COG3797 COG3797, Uncharacterized protein conserved in bacteria Function unknown 126699247 Common - hypothetical protein CD1643 11 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 126698772 Common rpmF 50S ribosomal protein L32 CD1176A 80 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 126700332 Pathogen - putative surface protein CD2717 3 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 126699453 Pathogen - putative RNA methyltransferase (partial) CD1844A 2 None None None 126697925 Common int-Tn integrase CD0355 126 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 126697615 Common proS prolyl-tRNA synthetase CD0049 247 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126697740 Pathogen - putative cyclic nucleotide-binding protein CD0168 1 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 126698555 Common - putative phage membrane protein CD0971 1 None None None 126700257 Common sigE sporulation sigma factor SigE CD2643 216 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 126698714 Common - putative transcriptional regulator CD1122 87 COG1396 HipB, Predicted transcriptional regulators Transcription 126699679 Common - hypothetical protein CD2062 3 None None None 126697811 Common - putative glycosyltransferase CD0240 106 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 126699713 Common - hypothetical protein CD2096 44 COG2378 COG2378, Predicted transcriptional regulator Transcription 126699784 Common hcp hydroxylamine reductase CD2168 75 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 126699990 Common - hypothetical protein CD2375 1 None None None 126700008 Common - putative transglycosylase CD2393 200 COG5009 MrcA, Membrane carboxypeptidase/penicillin-binding protein Cell envelope biogenesis, outer membrane 126698819 Common deoB phosphopentomutase CD1223 72 COG1015 DeoB, Phosphopentomutase Carbohydrate transport and metabolism 126699967 Common grdC glycine/sarcosine/betaine reductase complex component C beta subunit CD2349 8 COG3425 PksG, 3-hydroxy-3-methylglutaryl CoA synthase Lipid metabolism 126698436 Common oppD oligopeptide ABC transporter, ATP-binding protein CD0856 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 126701083 Common tkt transketolase, thiamine disphosphate-binding subunit CD3460 224 COG3959 COG3959, Transketolase, N-terminal subunit Carbohydrate transport and metabolism 126701051 Common cbiE cobalt-precorrin-6Y C(5)-methyltransferase CD3428 82 COG2241 CobL, Precorrin-6B methylase 1 Coenzyme metabolism 126697904 Common bclA1 putative exosporium glycoprotein CD0332 1 COG5651 COG5651, PPE-repeat proteins Cell motility and secretion 126700065 Common - putative radical SAM superfamily protein CD2448 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 126701283 Pathogen - hypothetical protein CD3656 1 None None None 126698989 Common - putative allophanate hydrolase subunit 1 CD1386 114 COG2049 DUR1, Allophanate hydrolase subunit 1 Amino acid transport and metabolism 126699989 Pathogen - hypothetical protein CD2374 1 None None None 126699997 Common - putative aspartate aminotransferase CD2382 99 COG1448 TyrB, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 126698447 Common modB putative molybdenum ABC transporter, permease protein CD0870 232 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 126700352 Common - putative carbon-nitrogen hydrolase CD2737 210 COG0388 COG0388, Predicted amidohydrolase General function prediction only 126700391 Common - putative minor teichoic acid biosynthesis protein CD2775 28 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 126697932 Common - two-component system, response regulator CD0362 217 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126698615 Common - putative cell wall anchored protein CD1031 27 None None None 126700168 Pathogen - hypothetical protein CD2551 1 None None None 126700215 Common pyrR PyrR bifunctional protein CD2595 115 COG2065 PyrR, Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase Nucleotide transport and metabolism 126701267 Common - probable carbohydrate kinase CD3640 60 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 126698604 Common - hypothetical protein CD1020 15 COG1285 SapB, Uncharacterized membrane protein Function unknown 126701137 Pathogen - pilin CD3513 1 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 126698652 Pathogen - hypothetical protein CD1065 1 None None None 126700189 Common - two-component sensor histidine kinase CD2570 219 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 126700292 Common ctfB butyrate--acetoacetate CoA-transferase subunit B CD2678 110 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 126700618 Common - putative iron ABC transporter, ATP-binding protein CD2997 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 126699852 Common - RpiR-family transcriptional regulator CD2235 126 COG1737 RpiR, Transcriptional regulators Transcription 126698524 Common - putative phage terminase, large subunit CD0944 17 COG1783 XtmB, Phage terminase large subunit General function prediction only 126699563 Common - putative ABC transporter, permease protein CD1954 38 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126698408 Common - putative oxidative stress protein CD0828 202 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 126698748 Common mgsA methylglyoxal synthase CD1153 88 COG1803 MgsA, Methylglyoxal synthase Carbohydrate transport and metabolism 126699978 Common - hypothetical protein CD2363 3 None None None 126701214 Common - two-component response regulator CD3587 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126698322 Common - putative ethanolamine transporter CD0742 18 COG3192 EutH, Ethanolamine utilization protein Amino acid transport and metabolism 126700495 Common - hypothetical protein CD2879 2 None None None 126697891 Common - two-component sensor histidine kinase CD0319 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126699956 Common abfH NAD-dependent 4-hydroxybutyrate dehydrogenase CD2338 166 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 126699393 Common truA2 tRNA pseudouridine synthase A CD1784 236 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 126699894 Common - putative sugar dehydrogenase CD2279 215 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 126700802 Common - D-aminoacylase CD3182 76 COG3653 COG3653, N-acyl-D-aspartate/D-glutamate deacylase Secondary metabolites biosynthesis, transport, and catabolism 126698251 Common - hypothetical protein CD0672 7 COG0327 COG0327, Uncharacterized conserved protein Function unknown 126700436 Common - hypothetical protein CD2820 13 COG0700 SpmB, Uncharacterized membrane protein Function unknown 126699882 Common - hypothetical protein CD2265 14 None None None 126697603 Common acoB acetoin:2,6-dichlorophenolindophenol oxidoreductase beta subunit CD0037 209 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 126698392 Common - putative universal stress protein CD0812 51 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 126697920 Common - hypothetical protein CD0350 11 COG5663 COG5663, Uncharacterized conserved protein Function unknown 126697601 Common - transcriptional regulator CD0035 69 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 126698908 Common infB translation initiation factor IF-2 CD1309 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 126698119 Common - chemotaxis protein CD0540 111 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 126698676 Common - two-component response regulator CD1089 57 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 126699211 Common - ABC transporter, ATP-binding protein CD1607 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126698297 Common cooC putative carbon monoxide dehydrogenase accessory protein CD0717 31 COG3640 CooC, CO dehydrogenase maturation factor Cell division and chromosome partitioning 126698291 Common - hypothetical protein CD0712 2 None None None 126701202 Common - putative sodium:solute symporter CD3575 90 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 126699552 Common - hypothetical protein CD1943 7 COG0316 IscA, Uncharacterized conserved protein Function unknown 126699462 Common - putative conjugative transposon membrane protein CD1853 5 None None None 126699698 Common xdhC xanthine dehydrogenase iron-sulfur binding subunit CD2081 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 126698897 Common pepA leucyl aminopeptidase CD1300 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 126697684 Common ptb phosphate butyryltransferase CD0112 140 COG0280 Pta, Phosphotransacetylase Energy production and conversion 126699106 Common - putative transcriptional regulator CD1503 44 COG1725 COG1725, Predicted transcriptional regulators Transcription 126697948 Pathogen - conjugative transposon protein CD0379 5 None None None 126697937 Common - two-component system, sensor histidine kinase CD0367 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126699701 Common - peptidase CD2084 213 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 126700620 Common - putative iron ABC transporter, substrate-binding protein CD2999 38 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 126699435 Common - MarR-family transcriptional regulator CD1827 59 COG1846 MarR, Transcriptional regulators Transcription 126697767 Common groEL 60 kDa chaperonin CD0194 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 126699754 Common rrf ribosome recycling factor CD2137 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 126699168 Common ilvC ketol-acid reductoisomerase CD1565 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 126700377 Common - putative N-acetylmuramoyl-L-alanine amidase CD2761 182 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 126699058 Common dnaG DNA primase CD1454 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 126699792 Common - probable amino-acid ABC transporter, permease protein CD2176 174 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 126699187 Common - hypothetical protein CD1583A 7 None None None 126698318 Common - hypothetical protein CD0738 4 None None None 126698610 Common potC putative spermidine/putrescine ABC transporter,permease protein CD1026 215 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 126698172 Common - hypothetical protein CD0594 18 COG3969 COG3969, Predicted phosphoadenosine phosphosulfate sulfotransferase General function prediction only 126700368 Pathogen - hypothetical protein CD2752 1 None None None 126698540 Pathogen - hypothetical protein CD0956B 1 None None None 126700824 Common - putative nitroreductase CD3205 66 COG0778 NfnB, Nitroreductase Energy production and conversion 126698767 Common etfA3 electron transfer flavoprotein alpha-subunit CD1172 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 126698035 Common - ABC transporter, ATP-binding protein CD0459 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126698176 Common cotJC1 putative spore-coat protein CD0598 46 COG3546 COG3546, Mn-containing catalase Inorganic ion transport and metabolism 126699527 Common - putative ethanolamine/propanediol utilisation aldehyde-alcohol dehydrogenase CD1917 178 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 126698932 Common xerD2 putative tyrosine recombinase CD1333 187 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 126700801 Common - putative chlorohydrolase/aminohydrolase CD3181 157 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 126700808 Common - putative iron-sulfur flavoprotein CD3189 51 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 126699839 Common - hypothetical protein CD2222 4 None None None 126698654 Pathogen - hypothetical protein CD1067 1 None None None 126699189 Common - putative N-acetylglucosamine kinase CD1585 62 COG2971 COG2971, Predicted N-acetylglucosamine kinase Carbohydrate transport and metabolism 126698853 Common trmD tRNA (Guanine-n(1)-)-methyltransferase CD1256 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 126698928 Common - putative nucleic acid-binding protein CD1329 78 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 126699920 Common - putative repressor (partial) CD2303 2 COG3682 COG3682, Predicted transcriptional regulator Transcription 126700286 Common appA oligopeptide ABC transporter, substrate-binding protein CD2672 205 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 126697753 Common - hypothetical protein CD0180 1 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 126700737 Common - putative transcriptional regulator CD3120 36 COG1476 COG1476, Predicted transcriptional regulators Transcription 126698331 Common - amino acid ABC transporter, permease protein CD0751 174 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 126701088 Common - hypothetical protein CD3465 153 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 126697798 Common - hypothetical protein CD0227 19 COG1728 COG1728, Uncharacterized protein conserved in bacteria Function unknown 126698913 Common ribC riboflavin biosynthesis protein CD1315 211 COG0196 RibF, FAD synthase Coenzyme metabolism 126700536 Common - scaffold protein CD2917 1 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 126697983 Pathogen - putative single-strand binding protein CD0413 2 None None None 126700754 Common bglA3 6-phospho-beta-glucosidase CD3136 102 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 126698466 Common speD S-adenosylmethionine decarboxylase proenzyme CD0889 73 COG1586 SpeD, S-adenosylmethionine decarboxylase Amino acid transport and metabolism 126698832 Pathogen - hypothetical protein CD1235 1 None None None 126700938 Common - hypothetical protein CD3319 27 COG0392 COG0392, Predicted integral membrane protein Function unknown 126699555 Common - AraC-family transcriptional regulator CD1946 11 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 126700647 Common malY putative bifunctional protein: repressor/cystathionine beta-lyase CD3029 228 COG1168 MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities Amino acid transport and metabolism 126700380 Common - putative hydrolase CD2764 126 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 126698609 Common potB spermidine/putrescine ABC transporter, permease protein CD1025 213 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 126699124 Pathogen - hypothetical protein CD1520 1 None None None 126698197 Common - hypothetical protein CD0619 2 None None None 126698874 Common - putative acetyltransferase CD1277 7 COG3393 COG3393, Predicted acetyltransferase General function prediction only 126700866 Common prdC putative electron transfer protein CD3247 125 COG4656 RnfC, Predicted NADH:ubiquinone oxidoreductase, subunit RnfC Energy production and conversion 126699868 Common - hypothetical protein CD2250 195 COG0628 PerM, Predicted permease General function prediction only 126698736 Common rnfB electron transport complex protein CD1142 133 COG2878 COG2878, Predicted NADH:ubiquinone oxidoreductase, subunit RnfB Energy production and conversion 126701114 Common spoIIE stage II sporulation protein e CD3490 55 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 126699318 Common - hypothetical protein CD1711 107 COG0393 COG0393, Uncharacterized conserved protein Function unknown 126698945 Common - hypothetical protein CD1346 6 COG4709 COG4709, Predicted membrane protein Function unknown 126698962 Pathogen - hypothetical protein CD1362 1 None None None 126698865 Common - ABC transporter, ATP-binding protein CD1268 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126697893 Common - hypothetical protein CD0321 6 None None None 126700723 Common - putative phopho-sugar aldolase CD3106 124 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 126699716 Common - putative molybdenum-binding subunit of oxidoreductase CD2099 113 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 126700041 Common - butyrate kinase CD2426 136 COG3426 COG3426, Butyrate kinase Energy production and conversion 126698582 Common - hypothetical protein CD0998 73 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 126698917 Common comR polynucleotide phosphorylase/polyadenylase CD1318 239 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 126698352 Common sigF RNA polymerase sigma-F factor CD0772 216 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 126699059 Common rpoD1 RNA polymerase sigma factor (sigma-43) CD1455 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 126701181 Common - pantothenate kinase CD3555 132 COG1521 COG1521, Putative transcriptional regulator, homolog of Bvg accessory factor Transcription 126697613 Common ispD 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CD0047 193 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 126697670 Common rplQ 50S ribosomal protein L17 CD0099 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 126698401 Common - two-component sensor histidine kinase CD0821 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126698157 Common - TetR-family transcriptional regulator CD0579 29 COG1309 AcrR, Transcriptional regulator Transcription 126699158 Common hisI histidine biosynthesis bifunctional protein CD1554 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 126699752 Common uppS undecaprenyl pyrophosphate synthetase CD2136 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 126700064 Common - histidine triad nucleotide-binding protein CD2447 236 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 126697593 Common radA DNA repair protein RadA CD0027 239 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 126699896 Common - PTS system, IIb component CD2281 9 COG3414 SgaB, Phosphotransferase system, galactitol-specific IIB component Carbohydrate transport and metabolism 126699277 Common - two-component sensor histidine kinase CD1672 209 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126699976 Common - hypothetical protein CD2360 5 None None None 126700524 Pathogen - phage lipoprotein CD2907 1 None None None 126698660 Common - GntR-family transcriptional regulator CD1073 145 COG2188 PhnF, Transcriptional regulators Transcription 126699245 Common - hypothetical protein CD1641 24 None None None 126698565 Pathogen - hypothetical protein CD0981 1 None None None 126700037 Common acp sodium/proton-dependent alanine carrier protein CD2422 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 126697962 Common - hypothetical protein CD0393 2 COG4720 COG4720, Predicted membrane protein Function unknown 126698143 Common - putative ATP-binding protein CD0564 107 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 126698649 Pathogen - hypothetical protein CD1063B 1 None None None 126698428 Common - hypothetical protein CD0848 3 None None None 126699236 Common asnB asparagine synthetase CD1632 154 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 126699660 Common - putative hydrolase CD2043 8 None None None 126698512 Pathogen - hypothetical protein CD0934 1 None None None 126698547 Common - phage protein CD0963 6 None None None 126699377 Common - hypothetical protein CD1768 6 None None None 126700305 Common hpt putative phosphoribosyltransferase CD2691 160 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 126698349 Common - putative formate dehydrogenase CD0769 182 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 126700508 Pathogen - hypothetical protein CD2892 1 None None None 126699257 Common - putative lipoprotein CD1653 100 COG1464 NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen Inorganic ion transport and metabolism 126697862 Common - hypothetical protein CD0290 4 None None None 126700231 Common - hypothetical protein CD2617 75 COG1284 COG1284, Uncharacterized conserved protein Function unknown 126700702 Common - alpha-mannosidase CD3085 51 COG0383 AMS1, Alpha-mannosidase Carbohydrate transport and metabolism 126698396 Common - PTS system, IIabc component CD0816 60 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 126697818 Common fliE flagellar hook-basal body protein FliE CD0247 52 COG1677 FliE, Flagellar hook-basal body protein Cell motility and secretion / Intracellular trafficking and secretion 126699153 Common hisC putative histidinol-phosphate aminotransferase CD1549 241 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 126700882 Common - putative phosphate ABC transporter, permease protein CD3263 225 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 126697870 Common rbsR putative ribose operon repressor CD0298 130 COG1609 PurR, Transcriptional regulators Transcription 126698632 Common - phosphodiesterase CD1048 50 COG0622 COG0622, Predicted phosphoesterase General function prediction only 126700501 Common - GntR-family transcriptional regulator CD2885 132 COG2188 PhnF, Transcriptional regulators Transcription 126697695 Common murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase CD0123 213 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 126699867 Common - putative ATPase CD2249 96 COG0714 COG0714, MoxR-like ATPases General function prediction only 126700843 Common dapA1 dihydrodipicolinate synthase CD3223 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 126700653 Common - hypothetical protein CD3035 123 COG0384 COG0384, Predicted epimerase, PhzC/PhzF homolog General function prediction only 126700475 Common - putative D-aminoacylase CD2859 62 COG3653 COG3653, N-acyl-D-aspartate/D-glutamate deacylase Secondary metabolites biosynthesis, transport, and catabolism 126698695 Common - putative DNA primase CD1105 30 COG4227 COG4227, Antirestriction protein DNA replication, recombination, and repair 126698643 Common thlA1 acetyl-CoA acetyltransferase CD1059 187 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 126700818 Common - putative ABC transporter, permease protein CD3199 2 None None None 126700920 Common lon ATP-dependent protease La CD3301 215 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 126700639 Common - putative transporter CD3019 52 COG1275 TehA, Tellurite resistance protein and related permeases Inorganic ion transport and metabolism 126700927 Common rph ribonuclease Ph CD3308 238 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 126700249 Common - hypothetical protein CD2635 9 None None None 126701139 Common gcaD bifunctional protein CD3515 238 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 126699458 Common - putative conjugal transfer protein CD1849 73 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 126700905 Common - putative sodium-dependent phosphate transporter CD3286 153 COG1283 NptA, Na+/phosphate symporter Inorganic ion transport and metabolism 126699216 Common - putative amidohydrolase CD1612 88 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 126699264 Common - hypothetical protein CD1660 53 COG3123 COG3123, Uncharacterized protein conserved in bacteria Function unknown 126697843 Common fliN putative flagellar motor switch protein CD0271 116 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 126697969 Common etfB1 electron transfer flavoprotein beta-subunit CD0400 152 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 126700467 Common dltC D-alanine--poly(phosphoribitol) ligase subunit 2 (D-alanyl carrier protein) CD2851 11 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 126700595 Common - putative acetyltransferase CD2973 54 COG0456 RimI, Acetyltransferases General function prediction only 126698190 Common - putative ABC transporter, permease protein CD0612 11 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126699740 Common - putative multiprotein-complex assembly protein CD2123 130 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 126698381 Common - probable permease CD0801 61 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 126697577 Common sigB RNA polymerase sigma-B factor CD0011 216 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 126699704 Common - putative xanthine dehydrogenase CD2087 120 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 126697845 Common htpG heat shock protein 90 CD0273 149 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 126700513 Pathogen - hypothetical protein CD2896 1 None None None 126699811 Common - ferritin CD2195 85 COG1528 Ftn, Ferritin-like protein Inorganic ion transport and metabolism 126697806 Common fliS1 flagellar protein FliS CD0235 52 COG1516 FliS, Flagellin-specific chaperone FliS Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 126699204 Common thiK hydroxyethylthiazole kinase CD1600 79 COG2145 ThiM, Hydroxyethylthiazole kinase, sugar kinase family Coenzyme metabolism 126698421 Common - 5-aminoimidazole-4-carboxamide ribonucleotide transformylase CD0841 218 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 126699760 Common - putative transcriptional regulator CD2143 2 COG3339 COG3339, Uncharacterized conserved protein Function unknown 126700357 Common - putative hydrolase CD2742 225 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 126698129 Common - hypothetical protein CD0550 5 None None None 126697867 Common - putative iron-sulfur-binding protein CD0295 29 COG2768 COG2768, Uncharacterized Fe-S center protein General function prediction only 126698488 Common - putative phage regulatory protein CD0911 2 COG3655 COG3655, Predicted transcriptional regulator Transcription 126698856 Common - branched-chain amino acid transport system carrier protein CD1259 50 COG1114 BrnQ, Branched-chain amino acid permeases Amino acid transport and metabolism 126699364 Common def1 peptide deformylase 1 CD1756 213 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 126701156 Common phnM putative amidohydrolase CD3532 55 COG3454 COG3454, Metal-dependent hydrolase involved in phosphonate metabolism Inorganic ion transport and metabolism 126698122 Common - hypothetical protein CD0543 29 None None None 126697588 Common - putative translation elongation factor CD0022 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 126699029 Pathogen - hypothetical protein CD1424 1 None None None 126697884 Common - ArsR-family transcriptional regulator CD0312 160 COG0640 ArsR, Predicted transcriptional regulators Transcription 126698029 Pathogen - hypothetical protein CD0453B 1 None None None 126697715 Common secA1 preprotein translocase SecA subunit CD0143 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 126697971 Common - sigma-54-dependent transcriptional regulator CD0402 168 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 126698306 Common - acetyl-CoA decarbonylase/synthase complex subunit gamma CD0726 22 COG1456 CdhE, CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) Energy production and conversion 126701173 Common - putative DNA polymerase III, delta' subunit CD3549 243 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 126698818 Common xerD1 putative tyrosine recombinase CD1222 206 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 126699531 Common - putative ethanolamine utilization/propanediol conserved hypothetical protein CD1921 5 None None None 126700452 Common - putative peptidase CD2836 169 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 126701270 Common - dihydroorotase CD3643 26 COG3964 COG3964, Predicted amidohydrolase General function prediction only 126701232 Common - putative phosphatase CD3605 158 COG0546 Gph, Predicted phosphatases General function prediction only 126700690 Common - hypothetical protein CD3073 15 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 126697918 Common - putative phosphoesterase CD0346 17 COG1768 COG1768, Predicted phosphohydrolase General function prediction only 126699178 Common - hypothetical protein CD1575 32 COG3584 COG3584, Uncharacterized protein conserved in bacteria Function unknown 126700266 Common ftsW cell division/stage V sporulation protein CD2652 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 126700630 Common - putative cytochrome C biogenesis protein CD3010 182 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 126700207 Common rpoZ DNA-directed RNA polymerase omega chain CD2587A 20 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 126698849 Common ffh signal recognition particle protein CD1252 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 126700381 Common - putative penicillin-binding protein repressor CD2765 61 COG1316 LytR, Transcriptional regulator Transcription 126701225 Common luxS S-ribosylhomocysteinase CD3598 56 COG1854 LuxS, LuxS protein involved in autoinducer AI2 synthesis Signal transduction mechanisms 126699986 Common nadB L-aspartate oxidase CD2371 226 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 126701013 Common - conjugative transposon protein CD3391 6 None None None 126699171 Common - hypothetical protein CD1568 105 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 126698690 Pathogen - hypothetical protein CD1103 1 None None None 126701026 Common - putative formate/nitrite transporter CD3403 100 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 126698203 Common - putative phage-related replicative helicase CD0626 218 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 126700680 Common - hypothetical protein CD3063 7 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 126699506 Pathogen - putative lipoprotein CD1896 1 None None None 126698101 Common - two-component sensor histidine kinase CD0520 221 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 126700312 Common - hypothetical protein CD2698 12 COG0700 SpmB, Uncharacterized membrane protein Function unknown 126699790 Common - probable amino-acid ABC transporter,substrate-binding protein CD2174 161 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 126700729 Common - putative amidohydrolase CD3112 168 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 126700126 Common - PTS system, IIbc component CD2510 54 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 126699370 Common - hypothetical protein CD1761 106 COG0384 COG0384, Predicted epimerase, PhzC/PhzF homolog General function prediction only 126700956 Common - putative cell wall hydrolase CD3336 131 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 126699372 Common - hypothetical protein CD1763 11 COG3326 COG3326, Predicted membrane protein Function unknown 126700720 Common - putative PTS syste, IIa component CD3103 60 COG2190 NagE, Phosphotransferase system IIA components Carbohydrate transport and metabolism 126698117 Common - putative methyl accpeting chemotaxis protein CD0538 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 126699294 Common - two-component response regulator CD1688 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126701106 Common - putative zinc transporter CD3483 120 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 126699036 Common - putative ribonuclease CD1432 24 COG3341 COG3341, Predicted double-stranded RNA/RNA-DNA hybrid binding protein General function prediction only 126698709 Pathogen - hypothetical protein CD1117 1 None None None 126699297 Common trxB1 thioredoxin reductase CD1691 245 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 126698997 Pathogen - hypothetical protein CD1395 1 None None None 126699608 Common - putative proline iminopeptidase CD1997 26 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 126700627 Common - probable alcohol dehydrogenase CD3006 173 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 126700364 Common - putative radical SAM family protein CD2749 111 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 126698532 Common - phage protein CD0951 1 None None None 126697728 Common - putative membrane-associated CAAX amino terminal protease CD0156 35 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 126700874 Common - two-component response regulator CD3255 138 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 126698587 Common fumA fumarate hydratase CD1003 148 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 126699096 Common - putative two-component sensor histidine kinase CD1492 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126697771 Common - LysR-family transcriptional regulator (partial) CD0200 3 COG0583 LysR, Transcriptional regulator Transcription 126699014 Common - hypothetical protein CD1411 3 None None None 126699875 Common - hypothetical protein CD2258 9 None None None 126700853 Common - putative sigma-54 interacting protein CD3233 172 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 126699991 Common - hypothetical protein CD2376 131 COG0628 PerM, Predicted permease General function prediction only 126697712 Common - putative peptidase CD0140 127 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 126698760 Common - hypothetical protein CD1165 76 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 126698508 Pathogen - hypothetical protein CD0930A 1 None None None 126700130 Common tdcB threonine dehydratase catabolic CD2514 223 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 126699406 Common - putative pyridine nucleotide-disulfide oxidoreductase CD1797 245 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 126699643 Common - putative acetyltransferase CD2026 31 COG3153 COG3153, Predicted acetyltransferase General function prediction only 126698059 Common spaK putative lantibiotic resistance two-component sensor kinase CD0482 221 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 126697938 Common - two-component system, response regulator CD0368 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126698783 Common - hypothetical protein CD1187 7 None None None 126700082 Common - amino acid transporter CD2465 194 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 126698683 Common - putative lantibiotic ABC transporter,ATP-binding protein CD1097 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126700056 Common - hypothetical protein CD2440 203 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 126701193 Common - putative cell wall hydrolase CD3567 7 COG3858 COG3858, Predicted glycosyl hydrolase General function prediction only 126699308 Common thiC thiamine biosynthesis protein ThiC CD1702 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 126698597 Common - two-component system response regulator CD1013 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126698769 Common - hypothetical protein CD1174 25 COG1323 COG1323, Predicted nucleotidyltransferase General function prediction only 126700139 Common - hypothetical protein CD2522 199 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 126699080 Common - putative signaling protein CD1476 177 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 126699816 Common - putative oxidoreductase, ferredoxin subunit CD2199A 53 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 126699721 Common - putative ABC transporter, permease protein CD2104 10 None None None 126698674 Common zupT zinc transporter ZupT CD1087 84 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 126700861 Common prdB proline reductase CD3241 14 None None None 126698934 Common - MarR-family transcriptional regulator CD1335 48 COG1846 MarR, Transcriptional regulators Transcription 126699072 Common - putative iron-sulfur protein CD1468 58 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 126699137 Common - putative ABC transporter, permease protein CD1533 17 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 126698750 Common - hypothetical protein CD1155 1 None None None 126697778 Common - PTS system, IIc component CD0207 67 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 126700135 Common - cell surface protein CD2518 5 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126698656 Common - putative phosphatase CD1069 41 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 126701074 Common lacC putative tagatose-6-phosphate kinase CD3451 111 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 126697996 Common - putative mobilization protein CD0425 11 None None None 126699280 Common - putative transcriptional regulator CD1675 135 COG1733 COG1733, Predicted transcriptional regulators Transcription 126698957 Pathogen - hypothetical protein CD1358 1 None None None 126701213 Common - two-component sensor histidine kinase CD3586 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126700423 Common ruvC crossover junction endodeoxyribonuclease RuvC CD2807 197 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 126700530 Common - phage protein CD2911 2 None None None 126698476 Common dinB DNA polymerase IV CD0899 185 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 126700318 Common - putative permease CD2704 144 COG2252 COG2252, Permeases General function prediction only 126699900 Common - GntR-family transcriptional regulator CD2285 169 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 126698539 Pathogen - phage protein CD0956A 1 None None None 126699821 Common - probable esterase CD2204 75 COG0627 COG0627, Predicted esterase General function prediction only 126701200 Pathogen - hypothetical protein CD3573 1 None None None 126700185 Common - PTS system, IIa component CD2566 101 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 126698359 Common - putative amidohydrolase CD0779 163 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 126697828 Common motA chemotaxis protein CD0256 102 COG1291 MotA, Flagellar motor component Cell motility and secretion 126700015 Common cotJB2 putative spore-coat protein CD2400 9 None None None 126700784 Common - hypothetical protein CD3165 22 COG4335 COG4335, DNA alkylation repair enzyme DNA replication, recombination, and repair 126700426 Common - hypothetical protein CD2810 12 COG4905 COG4905, Predicted membrane protein Function unknown 126698131 Common sleB putative spore-cortex-lytic protein CD0552 33 COG2339 COG2339, Predicted membrane protein Function unknown 126700768 Common - hypothetical protein CD3151 7 None None None 126699270 Common cysK cysteine synthase A CD1665 221 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 126700559 Common - putative phage single stranded DNA binding protein CD2941 148 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 126701188 Common murI glutamate racemase CD3562 189 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 126699107 Common - ABC transporter, ATP-binding protein CD1504 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126697855 Common - putative transcription antiterminator CD0283 160 COG1221 PspF, Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain Transcription / Signal transduction mechanisms 126700901 Common pflD putative formate acetyltransferase CD3282 59 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 126699442 Common aroB 3-dehydroquinate synthase CD1833 205 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 126700982 Common - ABC transporter, permease protein CD3362 32 COG3694 COG3694, ABC-type uncharacterized transport system, permease component General function prediction only 126699104 Common tlpB transposase-like protein B CD1500 74 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 126697584 Common recD recombination protein CD0018 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 126699540 Common dinR SOS regulatory protein CD1931 172 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 126698378 Common - hypothetical protein CD0798 12 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 126698013 Common - cell surface protein CD0440 6 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126700484 Common - putative oxidoreductase CD2868 91 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 126698994 Common - putative endoribonuclease CD1392 131 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 126699018 Pathogen - hypothetical protein CD1415 1 COG3247 HdeD, Uncharacterized conserved protein Function unknown 126698572 Pathogen - hypothetical protein CD0988 1 None None None 126700456 Common serS2 seryl-tRNA synthetase CD2840 243 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 126700407 Common - cell surface protein (putative S-layer protein precursor) CD2791 7 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126699374 Common - Nudix-family hydrolase CD1765 13 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 126698136 Common - putative phosphoribulokinase/uridine kinase CD0557 156 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 126700119 Common - cation-transporting ATPase CD2503 232 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 126699580 Common - hypothetical protein CD1971 5 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 126699333 Pathogen - hypothetical protein CD1727 1 None None None 126699775 Common - hypothetical protein CD2159 12 COG4905 COG4905, Predicted membrane protein Function unknown 126699343 Common - putative transcriptional regulator CD1736 120 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 126699487 Common vexP3 ABC transporter, permease protein CD1875 15 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126700740 Common - ArsR-family transcriptional regulator CD3122 48 COG0640 ArsR, Predicted transcriptional regulators Transcription 126699940 Common tkt transketolase CD2322 223 COG3959 COG3959, Transketolase, N-terminal subunit Carbohydrate transport and metabolism 126699626 Common erm1(B) rRNA adenine N-6-methyltransferase (erythromycin resistance protein) CD2010 216 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 126701274 Common - PTS system, IIa component CD3647 32 COG1447 CelC, Phosphotransferase system cellobiose-specific component IIA Carbohydrate transport and metabolism 126701147 Common ksgA dimethyladenosine transferase CD3523 247 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 126698384 Common - electron transfer flavoprotein beta-subunit CD0804 152 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 126699144 Common - ABC transporter, permease protein CD1540 18 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126699359 Common - TetR-family transcriptional regulator CD1752 12 COG1309 AcrR, Transcriptional regulator Transcription 126697668 Common rpsD 30S ribosomal protein S4 CD0097 248 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 126699198 Common cysM putative O-acetylserine sulfhydrylase CD1594 229 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 126698741 Common mreC putative rod shape-determining protein CD1146 83 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 126699390 Common - putative lipoprotein CD1781 2 None None None 126698270 Common - putative short chain dehydrogenase CD0691 228 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 126698083 Common - group II intron reverse transcriptase/maturase CD0506 91 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 126698895 Common - hypothetical protein CD1298 20 COG3874 COG3874, Uncharacterized conserved protein Function unknown 126700264 Common - putative cell division protein CD2650 34 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 126698189 Common - two-component response regulator CD0611 146 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 126701098 Common atpI ATP synthase protein I CD3475 3 None None None 126698258 Common - hypothetical protein CD0679 5 None None None 126698160 Common - putative PEP-utilising kinase CD0582 185 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 126700975 Common - putative nitroreductase CD3355 58 COG0778 NfnB, Nitroreductase Energy production and conversion 126698959 Common - putative phage repressor CD1360 28 COG1476 COG1476, Predicted transcriptional regulators Transcription 126697742 Common - putative ABC transporter, ATP-binding protein CD0170 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 126697957 Common bglF PTS system, beta-glucoside-specific IIabc component CD0388 60 COG2190 NagE, Phosphotransferase system IIA components Carbohydrate transport and metabolism 126700993 Common - conjugative transposon protein CD3371 6 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 126700162 Common - cellulose synthase catalytic subunit (UDP-forming) CD2545 118 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 126698218 Pathogen - hypothetical protein CD0640 2 None None None 126698050 Common - putative iron-sulfur protein CD0474 22 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 126699191 Common - putative ribose ABC transporter, ATP-binding protein CD1587 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 126700735 Pathogen - hypothetical protein CD3118 1 None None None 126699657 Common - MerR-family transcriptional regulator CD2040 60 COG0789 SoxR, Predicted transcriptional regulators Transcription 126698371 Common - hypothetical protein CD0791 132 COG1739 COG1739, Uncharacterized conserved protein Function unknown 126699673 Common - hypothetical protein CD2056 7 None None None 126700400 Common - cell surface protein CD2784 172 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 126699601 Common - putative lipoprotein CD1992 1 None None None 126700792 Common tpi triosephosphate isomerase CD3172 223 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 126698967 Common - hypothetical protein CD1366 1 COG5412 COG5412, Phage-related protein Function unknown 126698073 Common orf22 conjugative transposon protein CD0497 6 None None None 126698979 Common - putative phage regulatory protein CD1378 15 None None None 126698423 Common - putative glycosyl transferase CD0843 140 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 126700832 Common - hypothetical protein CD3213 2 None None None 126700590 Common - putative AMP-binding protein CD2969 201 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 126700915 Common - putative type IV pilus-assembly protein CD3296 215 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 126699911 Pathogen - putative surface protein (partial) CD2295A 1 None None None 126699708 Common - putative xanthine/uracile permease CD2091 127 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 126698774 Common plsX fatty acid/phospholipid synthesis protein CD1178 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 126698804 Common - putative RNA methyltransferase CD1208 133 COG1189 COG1189, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 126700175 Common - hypothetical protein CD2557 33 None None None 126697782 Common licC CTP:phosphocholine cytidylyltransferase CD0211 165 COG4750 LicC, CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes Cell envelope biogenesis, outer membrane 126698416 Common - putative acetyltransferase CD0836 23 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 126697633 Common rpoB DNA-directed RNA polymerase subunit beta CD0066 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 126699631 Common ilvD dihydroxy-acid dehydratase CD2014 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 126699711 Common - putative restriction enzyme CD2094 41 COG1401 McrB, GTPase subunit of restriction endonuclease Defense mechanisms 126699807 Common - putative phosphoesterase CD2191 41 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 126698043 Common - putative hydrolase CD0467 90 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 126699319 Common moaB putative molybdenum cofactor biosynthesis protein CD1712 190 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 126700197 Common stk serine/threonine-protein kinase and phosphatase CD2578 167 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 126699389 Common - putative methylase CD1780 138 COG0116 COG0116, Predicted N6-adenine-specific DNA methylase DNA replication, recombination, and repair 126698078 Common orf18 conjugative transposon protein CD0500 15 COG4734 ArdA, Antirestriction protein General function prediction only 126698980 Common - putative phage regulatory protein CD1378A 5 COG3093 VapI, Plasmid maintenance system antidote protein General function prediction only 126700649 Common - transcription antiterminator CD3031 29 COG3711 BglG, Transcriptional antiterminator Transcription 126701091 Common atpD F0F1 ATP synthase subunit beta CD3468 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 126697945 Pathogen - conjugative transposon protein CD0375 7 None None None 126698062 Common - two-component sensor histidine kinase CD0485 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126699056 Common folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin e pyrophosphokinase CD1452 202 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 126698474 Common - hypothetical protein CD0897 1 None None None 126699558 Common - putative two-component sensor histidine kinase CD1949 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126700096 Common - hypothetical protein CD2479 93 COG1179 COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Coenzyme metabolism 126698181 Pathogen - hypothetical protein CD0603 1 None None None 126699691 Common pucC1 putative FAD-binding subunit of xanthine dehydrogenase dehydrogenase CD2074 17 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 126700954 Common - hypothetical protein CD3334 3 COG3708 COG3708, Uncharacterized protein conserved in bacteria Function unknown 126698491 Pathogen - hypothetical protein CD0914 1 None None None 126699616 Common effR MarR-family transcriptional regulator CD2004 39 COG1846 MarR, Transcriptional regulators Transcription 126698534 Common - hypothetical protein CD0953 2 None None None 126698814 Common - putative glycosyltransferase CD1218 13 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 126700350 Common - cell surface protein CD2735 21 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126697591 Common - ATP:guanido phosphotransferase CD0025 25 COG3869 COG3869, Arginine kinase Amino acid transport and metabolism 126701216 Common pyrAA1 carbamoyl phosphate synthase small subunit CD3589 233 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 126700749 Common - AraC-family transcriptional regulator CD3131 57 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 126698223 Common - putative lantibiotic ABC transporter,ATP-binding protein CD0645 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126697657 Common rpsE 30S ribosomal protein S5 CD0088 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 126699424 Common cmk cytidylate kinase CD1816 206 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 126699395 Pathogen - hypothetical protein CD1786 1 None None None 126697921 Pathogen - hypothetical protein CD0351 1 None None None 126698092 Pathogen orf5 conjugative transposon protein (partial) CD0510B 2 None None None 126700445 Common - hypothetical protein CD2829 57 COG2510 COG2510, Predicted membrane protein Function unknown 126700751 Common - transcription antiterminator CD3133 31 COG3711 BglG, Transcriptional antiterminator Transcription 126698440 Common - PTS system, IIa component CD0863 29 COG1447 CelC, Phosphotransferase system cellobiose-specific component IIA Carbohydrate transport and metabolism 126700775 Common - hypothetical protein CD3156B 1 None None None 126698926 Common pgsA CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase CD1327 202 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 126698320 Common - putative aminotransferase CD0740 161 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 126700603 Common - hypothetical protein CD2982 9 COG1583 COG1583, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 126700430 Common - GntR-family transcriptional regulator CD2814 129 COG1802 GntR, Transcriptional regulators Transcription 126701204 Common mdeA methionine gamma-lyase CD3577 217 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 126698563 Pathogen - putative phage regulatory protein CD0978 1 COG3682 COG3682, Predicted transcriptional regulator Transcription 126700815 Common - putative penicillin-binding protein CD3196 84 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 126698851 Common - hypothetical protein CD1254 68 COG1837 COG1837, Predicted RNA-binding protein (contains KH domain) General function prediction only 126699112 Common - putative iron-sulfur cluster-binding protein CD1508 78 COG0348 NapH, Polyferredoxin Energy production and conversion 126697697 Common - putative cell wall endopeptidase CD0125 102 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 126698295 Common - putative phosphate butyryltransferase CD0715 133 COG0280 Pta, Phosphotransacetylase Energy production and conversion 126698361 Common - penicillin-binding protein CD0781 204 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 126697765 Common cls cardiolipin synthetase CD0192 145 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 126698253 Pathogen - hypothetical protein CD0674 1 None None None 126697829 Common motB chemotaxis protein CD0257 159 COG1360 MotB, Flagellar motor protein Cell motility and secretion 126698842 Common efp elongation factor P CD1246 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 126700884 Common - two-component response regulator CD3265 218 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126701128 Common - putative type IV prepilin leader peptidase CD3504 121 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 126700667 Common - putative PTS system, IIb component CD3049 26 COG1440 CelA, Phosphotransferase system cellobiose-specific component IIB Carbohydrate transport and metabolism 126697909 Common - ABC transporter, permease protein CD0337 20 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126699464 Common - putative conjugative transposon membrane protein CD1855 4 None None None 126700299 Common - putative regulatory protein CD2685 108 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 126698906 Common - hypothetical protein CD1307A 58 COG2740 COG2740, Predicted nucleic-acid-binding protein implicated in transcription termination Transcription 126700549 Common - phage protein CD2931 17 COG4570 Rus, Holliday junction resolvase DNA replication, recombination, and repair 126698758 Common rpmA 50S ribosomal protein L27 CD1163 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 126700073 Common - ABC transporter, ATP-binding protein CD2456 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 126697608 Common - PTS system, IIb component CD0042 18 COG3414 SgaB, Phosphotransferase system, galactitol-specific IIB component Carbohydrate transport and metabolism 126698670 Common - PTS system, IIb component CD1083 18 COG3414 SgaB, Phosphotransferase system, galactitol-specific IIB component Carbohydrate transport and metabolism 126700821 Common - two-component sensor histidine kinase CD3202 222 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 126697934 Common - putative lantibiotic ABC transporter,ATP-binding protein CD0364 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126700655 Common - putative regulatory protein CD3037 4 COG1329 COG1329, Transcriptional regulators, similar to M. xanthus CarD Transcription 126700246 Common - putative GTP-binding protein CD2632 229 COG1160 COG1160, Predicted GTPases General function prediction only 126697731 Common - putative lantibiotic ABC transporter,ATP-binding protein CD0161 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 126700223 Common - putative response regulator CD2603 11 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 126699093 Common metN D-methionine ABC transporter, ATP-binding protein CD1489 249 COG1135 AbcC, ABC-type metal ion transport system, ATPase component Inorganic ion transport and metabolism 126698577 Common - putative thioesterase CD0993 23 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 126699272 Common - probable sugar O-acetyltransferase CD1667 109 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 126698368 Common - putative ATP/GTP-binding protein CD0788 227 COG2262 HflX, GTPases General function prediction only 126700375 Common - hypothetical protein CD2759 2 COG1959 COG1959, Predicted transcriptional regulator Transcription 126700810 Common - putative oxidoreductase CD3191 40 COG1453 COG1453, Predicted oxidoreductases of the aldo/keto reductase family General function prediction only 126700251 Common - two-component sensor histidine kinase CD2637 223 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 126697755 Pathogen - hypothetical protein CD0182 1 None None None 126701300 Common soj sporulation initiation inhibitor CD3672 227 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 126700611 Common - ABC transporter, ATP-binding protein CD2990 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 126700669 Common anmK anhydro-N-acetylmuramic acid kinase CD3051 120 COG2377 COG2377, Predicted molecular chaperone distantly related to HSP70-fold metalloproteases Posttranslational modification, protein turnover, chaperones 126700891 Common - hypothetical protein CD3272 17 COG4769 COG4769, Predicted membrane protein Function unknown 126699835 Common int integrase (partial) CD2218 90 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 126697873 Common rbsA ribose ABC transporter, ATP-binding protein CD0301 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 126701124 Common prsA putative foldase lipoprotein (late stage protein export lipoprotein) CD3500 163 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 126698765 Common - hypothetical protein CD1170 29 COG3875 COG3875, Uncharacterized conserved protein Function unknown 126698471 Common - iron-dependent hydrogenase CD0894 54 COG4624 COG4624, Iron only hydrogenase large subunit, C-terminal domain General function prediction only 126700144 Common - TetR-family transcriptional regulator CD2527 58 COG1309 AcrR, Transcriptional regulator Transcription 126698727 Pathogen - hypothetical protein CD1133 1 None None None 126699519 Common pduV putative ethanolamine/propanediol utilization protein CD1909 19 COG4917 EutP, Ethanolamine utilization protein Amino acid transport and metabolism 126700413 Pathogen - hypothetical protein CD2797 5 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 126700228 Common - hypothetical protein CD2614 52 COG1307 DegV, Uncharacterized protein conserved in bacteria Function unknown 126699837 Common - putative cAMP-binding regulatory protein CD2220 15 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 126699892 Common - sugar phosphate aldolase CD2277 159 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 126700478 Common - putative dipeptidase CD2862 103 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 126697628 Common rplK 50S ribosomal protein L11 CD0061 247 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 126699005 Common - putative nonribosomal peptide synthetase CD1403 202 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 126699592 Common - NUDIX-family protein CD1984 113 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 126697621 Common - putative tRNA/rRNA methyltransferase CD0055 215 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 126697570 Common recF DNA replication and repair protein CD0004 175 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 126701191 Common - GntR-family transcriptional regulator CD3565 146 COG1802 GntR, Transcriptional regulators Transcription 126700804 Common dpaL2 diaminopropionate ammonia-lyase CD3184 171 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 126698678 Pathogen xis excisionase CD1092 2 None None None 126700284 Common appF oligopeptide ABC transporter, ATP-binding protein CD2670 249 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 126698038 Common - two-component response regulator CD0462 211 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126700987 Pathogen - hypothetical protein CD3367 1 None None None 126697756 Common - putative cell wall hydrolase CD0183 135 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 126701170 Common - putative corrin/porphyrin methyltransferase CD3546 210 COG0313 COG0313, Predicted methyltransferases General function prediction only 126698111 Common - hypothetical protein CD0532 13 COG3708 COG3708, Uncharacterized protein conserved in bacteria Function unknown 126699877 Common - probable proton-dependent oligopeptide transporter CD2260 88 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 126699566 Common - two-component response regulator CD1957 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126699794 Common - putative iron-sulfur subunit of hydrogenase CD2178 169 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 126699326 Common tlpB transposase-like protein B CD1719 75 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 126697791 Common purF amidophosphoribosyltransferase CD0220 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 126698553 Common - hypothetical protein CD0969 1 None None None 126701103 Common rpiB2 ribose-5-phosphate isomerase 2 CD3480 129 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 126701264 Common - hypothetical protein CD3637 42 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 126697927 Pathogen - hypothetical protein CD0356A 1 None None None 126700711 Common - putative sigma-54-dependent transcriptional regulator CD3094 169 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 126699400 Pathogen - hypothetical protein CD1791 1 None None None 126699639 Pathogen - hypothetical protein CD2022 1 None None None 126697838 Common fliA RNA polymerase sigma factor for flagellar operon CD0266 216 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 126700361 Common recJ putative single-stranded-DNA-specific exonuclease CD2746 194 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 126700047 Common - putative nitrite/sulphite reductase CD2431 162 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 126699782 Common msrAB peptide methionine sulfoxide reductase CD2166 206 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 126698000 Common - hypothetical protein CD0429 11 None None None 126699494 Common - AraC-family transcriptional regulator CD1883 114 COG3708 COG3708, Uncharacterized protein conserved in bacteria Function unknown 126701081 Common - hypothetical protein CD3458 19 COG3949 COG3949, Uncharacterized membrane protein Function unknown 126698522 Pathogen - hypothetical protein CD0942 1 None None None 126700886 Common - two-component response regulator CD3267 215 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126700023 Common - putative multidrug efflux pump, outer membrane protein CD2408 5 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 126701235 Common - hypothetical protein CD3607 172 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 126700290 Common thlA2 putative acetyl-CoA acetyltransferase CD2676 183 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 126701057 Common cbiA cobyrinic acid a,c-diamide synthase CD3434 136 COG1797 CobB, Cobyrinic acid a,c-diamide synthase Coenzyme metabolism 126699180 Common pgm1 putative phosphoglucomutase CD1577 238 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 126698434 Common oppC oligopeptide ABC transporter, permease protein CD0854 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 126701242 Common - potassium/proton antiporter CD3616 132 COG3263 COG3263, NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain Inorganic ion transport and metabolism 126697732 Common - Radical SAM-family protein CD0162 86 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 126700660 Common - hypothetical protein CD3042 9 COG4129 COG4129, Predicted membrane protein Function unknown 126700217 Common lspA lipoprotein signal peptidase CD2597 94 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 126700945 Common - integrase CD3326 125 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 126699599 Common cspC cold shock protein CD1990B 180 COG1278 CspC, Cold shock proteins Transcription 126698009 Common - integrase (partial) CD0437 2 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 126699789 Common - putative peptidase CD2173 168 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 126701135 Common - type IV pilus assembly protein CD3511 139 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 126697864 Common - DNA-binding protein CD0292 18 COG1396 HipB, Predicted transcriptional regulators Transcription 126700393 Common - putative polysaccharide polymerase CD2777 3 None None None 126697789 Common purE phosphoribosylaminoimidazole carboxylase catalytic subunit CD0218 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 126698829 Common - cell surface protein CD1233 6 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126701066 Common - PTS system, IIc component CD3443 38 COG1455 CelB, Phosphotransferase system cellobiose-specific component IIC Carbohydrate transport and metabolism 126699987 Common nadA quinolinate synthetase CD2372 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 126697646 Common rpsC 30S ribosomal protein S3 CD0079 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 126701289 Common rpsR 30S ribosomal protein S18 CD3661A 213 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 126699163 Common - hypothetical protein CD1559 12 None None None 126697679 Common nrdD anaerobic ribonucleoside triphosphate reductase CD0108 107 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 126698685 Common - two-component response regulator CD1099 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126699520 Common - two-component response regulator CD1910 222 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 126697661 Common adk adenylate kinase CD0091 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 126701058 Common cbiP cobyric acid synthase CD3435 152 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 126698797 Common nusB N utilization substance protein B CD1201 148 COG0781 NusB, Transcription termination factor Transcription 126699087 Common ssuB putative aliphatic sulfonates ABC transporter,ATP-binding protein CD1483 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 126697745 Common fdxA ferredoxin CD0172A 193 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 126699366 Common - radical SAM-superfamily protein CD1758 106 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 126698485 Common - phage protein CD0908 12 None None None 126698637 Common - putative regulatory protein CD1053 96 COG2606 EbsC, Uncharacterized conserved protein Function unknown 126699218 Common - putative sodium extrusion ABC transporter,ATP-binding protein CD1614 249 COG4555 NatA, ABC-type Na+ transport system, ATPase component Energy production and conversion / Inorganic ion transport and metabolism 126699064 Common - putative phosphohydrolase CD1460 11 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 126698549 Common - phage protein CD0965 4 COG4385 gpI, Bacteriophage P2-related tail formation protein General function prediction only 126698343 Common gutM glucitol operon activator protein CD0763 14 COG4578 GutM, Glucitol operon activator Transcription 126699880 Common - putative protein export chaperone CD2263 156 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 126699926 Common - putative transcriptional regulator CD2308 53 COG1476 COG1476, Predicted transcriptional regulators Transcription 126699658 Common - putative regulatory protein CD2041 17 COG1396 HipB, Predicted transcriptional regulators Transcription 126699238 Common - tellurium resistance protein CD1634 31 COG2310 TerZ, Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 Signal transduction mechanisms 126697841 Common flgG flagellar basal body rod protein FlgG CD0269 126 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 126700465 Common - bifunctional protein CD2849 192 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 126698883 Common - hypothetical protein CD1286 20 None None None 126698514 Common - phage modification methylase CD0935 70 COG0338 Dam, Site-specific DNA methylase DNA replication, recombination, and repair 126700200 Common rsmB ribosomal RNA small subunit methyltransferase CD2581 210 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 126697889 Common - putative ABC transporter, permease protein CD0317 7 COG4200 COG4200, Uncharacterized protein conserved in bacteria Function unknown 126700002 Common - probable dehydrogenase CD2387 114 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 126699290 Common - radical SAM-superfamily protein CD1684 3 COG1244 COG1244, Predicted Fe-S oxidoreductase General function prediction only 126700307 Common - putative sodium:dicarboxylate symporter CD2693 128 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 126700253 Common - hypothetical protein CD2639 172 COG1496 COG1496, Uncharacterized conserved protein Function unknown 126699476 Common - putative conjugative transposon DNA recombination protein CD1865 46 COG3593 COG3593, Predicted ATP-dependent endonuclease of the OLD family DNA replication, recombination, and repair 126699231 Common - putative D-alanyl-D-alanine carboxypeptidase CD1627 31 COG1876 VanY, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 126699255 Common - putative signaling protein CD1651 166 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 126700519 Common - phage protein CD2902 2 None None None 126700907 Pathogen - hypothetical protein CD3288 1 None None None 126697898 Common cbiQ cobalt transport protein CD0326 39 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 126698195 Common - hypothetical protein CD0617 7 None None None 126699266 Common tlpB transposase-like protein B CD1661 75 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 126700460 Common - MarR-family transcriptional regulator CD2844 47 COG1846 MarR, Transcriptional regulators Transcription 126701244 Common - hypothetical protein CD3618 12 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 126699865 Common cspBA putative germination-specific protease CD2247 38 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 126701005 Pathogen - conjugative transposon membrane protein CD3384 7 None None None 126699161 Common - putative peptidyl-prolyl isomerase CD1557 157 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 126698328 Common - putative signaling protein CD0748 177 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 126698350 Common spoIIAA anti-sigma F factor antagonist CD0770 61 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 126698456 Common - putative carbohydrate kinase CD0879 222 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 126698953 Common - hypothetical protein CD1354 8 None None None 126701068 Common - PTS system, IIa component CD3445 30 COG1447 CelC, Phosphotransferase system cellobiose-specific component IIA Carbohydrate transport and metabolism 126700327 Common - cell surface protein CD2713 99 COG5263 COG5263, FOG: Glucan-binding domain (YG repeat) General function prediction only 126701101 Common - hypothetical protein CD3478 24 COG3608 COG3608, Predicted deacylase General function prediction only 126698095 Common - cell surface protein (putative hemagglutinin/adhesin) CD0514 145 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126697579 Common - putative mechanosensitive ion channel protein CD0013 215 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 126701198 Common - hypothetical protein CD3571 2 COG3318 COG3318, Predicted metal-binding protein related to the C-terminal domain of SecA General function prediction only 126699078 Common - putative ruberythrin CD1474 21 COG1592 COG1592, Rubrerythrin Energy production and conversion 126700031 Common - putative transcription antiterminator CD2416 33 COG3711 BglG, Transcriptional antiterminator Transcription 126698150 Common - hypothetical protein CD0572 14 None None None 126701237 Pathogen - hypothetical protein CD3609 1 None None None 126698828 Common - putative lipoprotein CD1232 8 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 126700922 Common chrA' chromate transport protein CD3303 98 COG2059 ChrA, Chromate transport protein ChrA Inorganic ion transport and metabolism 126698779 Common acpP acyl carrier protein CD1183 210 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 126701039 Common - ABC transporter, permease protein CD3416 151 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 126698240 Common tcdA toxin A CD0663 24 COG5263 COG5263, FOG: Glucan-binding domain (YG repeat) General function prediction only 126698280 Common - hypothetical protein CD0701 14 COG3027 COG3027, Uncharacterized protein conserved in bacteria Function unknown 126700816 Common - MerR-family transcriptional regulator CD3197 31 COG0789 SoxR, Predicted transcriptional regulators Transcription 126699746 Common - putative membrane-associated protease CD2129 221 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 126700021 Common - putative lipoprotein CD2406 171 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 126700608 Common - two-component system histidine kinase CD2987 214 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126700142 Common recX recombination regulator RecX CD2525 23 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 126701308 Common rpmH 50S ribosomal protein L34 CD3680 192 None None None 126698357 Common - hypothetical protein CD0777 22 None None None 126700601 Common - hypothetical protein CD2980 11 COG1857 COG1857, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 126697796 Common purL formylglycinamidine ribonucleotide synthetase CD0225 233 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 126700534 Pathogen - hypothetical protein CD2915 1 None None None 126698468 Common speB putative agmatinase CD0891 147 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 126699973 Common grdX putative glycine reductase complex component CD2357 6 None None None 126700756 Common - transcription antiterminator CD3138 29 COG3711 BglG, Transcriptional antiterminator Transcription 126698734 Common rnfE electron transport complex protein CD1140 76 COG4660 RnfE, Predicted NADH:ubiquinone oxidoreductase, subunit RnfE Energy production and conversion 126699285 Common - putative flavodoxin CD1679 5 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 126698844 Common rnc putative ribonuclease III CD1248 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 126700951 Common - TetR-family transcriptional regulator CD3332 18 COG1309 AcrR, Transcriptional regulator Transcription 126700193 Common - putative thiamine pyrophosphokinase CD2574 49 COG1564 THI80, Thiamine pyrophosphokinase Coenzyme metabolism 126697824 Common fliK putative flagellar hook-length control protein CD0253 4 COG3144 FliK, Flagellar hook-length control protein Cell motility and secretion 126697882 Common - hypothetical protein CD0310 2 None None None 126701086 Common alr alanine racemase CD3463 200 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 126698947 Pathogen - putative lipoprotein CD1348 1 None None None 126699154 Common hisB imidazoleglycerol-phosphate dehydratase CD1550 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 126699433 Common cysD putative O-acetylhomoserine sulfhydrylase CD1825 206 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 126699316 Common - putative molybdopterin-guanine biosynthesis protein CD1709 116 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 126698867 Common - two-component sensor histidine kinase CD1270 131 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 126700822 Common - two-component response regulator CD3203 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126701015 Common - putative collagen-binding surface protein CD3392 9 COG4932 COG4932, Predicted outer membrane protein Cell envelope biogenesis, outer membrane 126700727 Common - 6-phosphofructokinase CD3110 158 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 126700764 Common - putative DNA-methyltransferase CD3147 100 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 126699937 Common rpe putative ribulose-phosphate 3-epimerase CD2319 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 126698838 Pathogen - hypothetical protein CD1242 1 None None None 126700689 Common - hypothetical protein CD3072 10 COG5418 COG5418, Predicted secreted protein Function unknown 126700622 Common - putative isomerase/hydrolase CD3001 177 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 126698964 Common - hypothetical protein CD1364 6 None None None 126698103 Common - putative signaling protein CD0522 180 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 126698141 Common - putative endonuclease CD0562 4 COG4570 Rus, Holliday junction resolvase DNA replication, recombination, and repair 126700039 Common - putative aminotransferase CD2424 228 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 126698155 Common - hypothetical protein CD0577 31 COG2316 COG2316, Predicted hydrolase (HD superfamily) General function prediction only 126700159 Common - hypothetical protein CD2542 2 None None None 126700132 Common - putative L-asparaginase CD2516 137 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 126698936 Common - RpiR-family transcriptional regulator CD1337 107 COG1737 RpiR, Transcriptional regulators Transcription 126697960 Common - asparagine synthetase (glutamine-hydrolyzing) CD0391 150 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 126699910 Pathogen - hypothetical protein CD2295 1 None None None 126700526 Common - phage protein CD2908 6 None None None 126698154 Common - two-component sensor histidine kinase CD0576 10 COG2972 COG2972, Predicted signal transduction protein with a C-terminal ATPase domain Signal transduction mechanisms 126697626 Common secE preprotein translocase SecE subunit CD0059 28 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 126698287 Common pepD putative aminoacyl-histidine dipeptidase CD0708 60 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 126699930 Common modB ABC transporter, permease protein CD2312 223 COG0555 CysU, ABC-type sulfate transport system, permease component Posttranslational modification, protein turnover, chaperones 126698911 Common tlpB transposase-like protein B CD1312 74 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 126699471 Common - putative conjugative transposon conserved hypothetical protein CD1860 51 COG4804 COG4804, Uncharacterized conserved protein Function unknown 161723227 Common rpsL 30S ribosomal protein S12 CD0068 245 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 126697707 Common - PTS system, IIa component CD0135 32 COG1447 CelC, Phosphotransferase system cellobiose-specific component IIA Carbohydrate transport and metabolism 126699061 Common - hypothetical protein CD1457 115 COG3323 COG3323, Uncharacterized protein conserved in bacteria Function unknown 126701183 Common - putative peptidase CD3557 52 COG3191 DmpA, L-aminopeptidase/D-esterase Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 126698120 Common cheR chemotaxis protein methyltransferase CD0541 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 126700137 Common - hypothetical protein CD2520 5 COG4767 VanZ, Glycopeptide antibiotics resistance protein Defense mechanisms 126697686 Common - putative ATP/GTP-binding protein CD0114 15 None None None 126700090 Common rpsT 30S ribosomal protein S20 CD2473 189 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 126699404 Common - hypothetical protein CD1795 6 None None None 126700557 Pathogen - hypothetical protein CD2939 1 None None None 126699984 Common - hypothetical protein CD2369 10 None None None 126698663 Common - PTS system, IIb component CD1076 40 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 126699826 Common - putative GTP-binding protein CD2209 214 COG2262 HflX, GTPases General function prediction only 126697598 Common - putative beta-glucosidase CD0032 11 COG2730 BglC, Endoglucanase Carbohydrate transport and metabolism 126698315 Common - hypothetical protein CD0735 11 None None None 126699954 Common - putative toxic anion resistance protein CD2336 32 COG3853 TelA, Uncharacterized protein involved in tellurite resistance Inorganic ion transport and metabolism 126698501 Pathogen - hypothetical protein CD0924 2 None None None 126700276 Common - putative GTP-binding protein CD2662 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 126700632 Common - putative glycosyl hydrolase CD3012 40 COG0383 AMS1, Alpha-mannosidase Carbohydrate transport and metabolism 126699455 Common - hypothetical protein CD1846 23 COG4283 COG4283, Uncharacterized conserved protein Function unknown 126700863 Common prdA proline reductase subunit proprotein CD3244 8 None None None 126698081 Common orf15 conjugative transposon membrane protein CD0503 14 COG4372 COG4372, Uncharacterized protein conserved in bacteria with the myosin-like domain Function unknown 126699022 Common - putative integrase (partial) CD1418A 33 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 126698650 Pathogen - hypothetical protein CD1063C 1 None None None 126699135 Common - two-component response regulator CD1531 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126700388 Common tuaG putative teichuronic acid biosynthesis glycosyl transferase CD2772 217 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 126697822 Common fliI flagellum-specific ATP synthase CD0251 247 COG1157 FliI, Flagellar biosynthesis/type III secretory pathway ATPase Cell motility and secretion / Intracellular trafficking and secretion 126700575 Common ntpA V-type ATP synthase subunit A CD2956 247 COG1155 NtpA, Archaeal/vacuolar-type H+-ATPase subunit A Energy production and conversion 126699569 Common - two-component sensor histidine kinase CD1960 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126700339 Common - probable polysaccharide deacetylase CD2724 97 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 126701254 Common - putative sugar-phosphate isomerase CD3628 167 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 126699282 Common - hypothetical protein CD1677 27 COG3817 COG3817, Predicted membrane protein Function unknown 126701021 Common - putative DNA repair protein (nucleotide pyrophosphatase) CD3398 62 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 126699959 Common abfD gamma-aminobutyrate metabolism dehydratase/isomerase CD2341 50 COG2368 COG2368, Aromatic ring hydroxylase Secondary metabolites biosynthesis, transport, and catabolism 126700498 Common celF 6-phospho-beta-glucosidase CD2882 54 COG1486 CelF, Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases Carbohydrate transport and metabolism 126698872 Common codY transcriptional repressor CodY CD1275 20 COG4465 CodY, Pleiotropic transcriptional repressor Transcription 126700349 Common mleN putative malate-2H(+)/Na(+)-lactate antiporter CD2734 53 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 126699538 Common - hypothetical protein CD1929 73 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 126700511 Common - phage holin CD2894A 1 None None None 126697847 Common spl spore photoproduct lyase CD0275 27 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 126698333 Common iscS1 putative cysteine desulfurase CD0753 239 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 126699082 Common feoA1 putative ferrous iron transport protein A CD1478 58 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 126701116 Pathogen - putative septum formation protein CD3492 1 None None None 126698269 Common - putative nucleotide phosphodiesterase CD0690 93 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 126701049 Common cbiF precorrin-4 C(11)-methyltransferase CD3426 202 COG2875 CobM, Precorrin-4 methylase Coenzyme metabolism 126700593 Pathogen - hypothetical protein CD2972 1 None None None 126698461 Common glgA glycogen synthase CD0884 139 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 126700766 Common - putative DNA helicase CD3149 28 COG1205 COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster General function prediction only 126699902 Common - hypothetical protein CD2287 23 COG4392 COG4392, Predicted membrane protein Function unknown 126698053 Pathogen tlpB' transposase-like protein B (remnant) CD0476A 1 None None None 126698221 Common - two-component response regulator CD0643 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126699843 Common sat streptogramin A acetyltransferase CD2226 164 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 126698388 Pathogen - hypothetical protein CD0808 1 None None None 126700782 Common - hypothetical protein CD3163 11 None None None 126700183 Common - MerR-family transcriptional regulator CD2564 112 COG0789 SoxR, Predicted transcriptional regulators Transcription 126699662 Common - putative transcriptional regulator CD2045 51 COG3655 COG3655, Predicted transcriptional regulator Transcription 126697869 Common - putative biotin synthase CD0297 184 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 126700302 Common sspA small acid-soluble spore protein A CD2688 15 None None None 126698795 Common spoIIIAH putative stage III sporulation protein AH CD1199 15 None None None 126697681 Common - hypothetical protein CD0110 67 COG1624 COG1624, Uncharacterized conserved protein Function unknown 126698397 Common tlpB putative transposase-like protein B CD0817 74 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 126699917 Pathogen - hypothetical protein CD2301 1 None None None 126699358 Common - cell surface protein (putative cell surface-associated cysteine protease) CD1751 21 COG4870 COG4870, Cysteine protease Posttranslational modification, protein turnover, chaperones 126699962 Common - hypothetical protein CD2344 57 COG2985 COG2985, Predicted permease General function prediction only 126697644 Common rpsS 30S ribosomal protein S19 CD0077 239 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 126699422 Common - putative phosphoglycerate mutase CD1814 187 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 126697655 Common rplF 50S ribosomal protein L6 CD0086 238 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 126699517 Common pduQ putative ethanolamine/propanediol utilization propanol dehydrogenase CD1907 175 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 126698780 Common fabF 3-oxoacyl-[acyl-carrier-protein] synthase II CD1184 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 126700868 Common sspB small acid-soluble spore protein B CD3249 14 None None None 126700672 Common - putative ABC transporter, permease protein CD3055 17 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126697586 Common - hypothetical protein CD0020 2 None None None 126697977 Pathogen - hypothetical protein CD0408A 1 None None None 126697955 Pathogen - hypothetical protein CD0385A 1 None None None 126700013 Common - hypothetical protein CD2398 162 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 126700114 Common - D-alanyl-D-alanine carboxypeptidase (putative sporulation-specific penicillin-binding protein) CD2498 156 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 126699175 Common tlpB transposase-like protein B CD1572 73 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 126698805 Common recN DNA repair protein CD1209 225 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 126700128 Common - PTS system, IIa component CD2512 60 COG2190 NagE, Phosphotransferase system IIA components Carbohydrate transport and metabolism 126700550 Pathogen - hypothetical protein CD2932 1 None None None 126698706 Pathogen - hypothetical protein CD1114 1 None None None 126699027 Common - MerR-family transcriptional regulator CD1422 103 COG0789 SoxR, Predicted transcriptional regulators Transcription 126699038 Pathogen - hypothetical protein CD1434 1 None None None 126701076 Common agaA N-acetylglucosamine-6-phosphate deacetylase CD3453 118 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 126699173 Common - putative lysophospholipase CD1570 81 COG2267 PldB, Lysophospholipase Lipid metabolism 126698027 Common - putative phosphohydrolase CD0453 87 COG0546 Gph, Predicted phosphatases General function prediction only 126700366 Common agrB accessory gene regulator CD2750 3 COG4512 AgrB, Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Transcription 126698167 Pathogen - hypothetical protein CD0589 2 COG4987 CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 126699418 Common - putative regulatory protein CD1810 18 COG3682 COG3682, Predicted transcriptional regulator Transcription 126698785 Common - putative amino acid permease CD1189 182 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 126700917 Common - putative ATP/GTP-binding protein CD3298 10 None None None 126698700 Common - putative DNA-repair protein CD1108 7 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 126698550 Common - putative phage tail fiber protein CD0966 23 COG5301 COG5301, Phage-related tail fibre protein General function prediction only 126700570 Common - phage protein CD2951 7 None None None 126700973 Common - GntR-family transcriptional regulator CD3353 179 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 126699510 Pathogen - hypothetical protein CD1900 1 None None None 126699299 Common - putative dinitrogenase iron-molybdenum cofactor CD1693 13 COG1433 COG1433, Uncharacterized conserved protein Function unknown 126698599 Common - putative signaling protein CD1015 179 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126699305 Common ribB riboflavin synthase subunit alpha CD1699 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 126698205 Common - putative ferredoxin CD0627A 85 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 126700009 Common - putative DNA polymerase III, epsilon chain CD2394 65 COG2176 PolC, DNA polymerase III, alpha subunit (gram-positive type) DNA replication, recombination, and repair 126700613 Pathogen - hypothetical protein CD2992 2 None None None 126699279 Common - putative NADPH-dependent FMN reductase CD1674 43 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 126700704 Common - phosphosugar-binding transcriptional regulator CD3087 54 COG1737 RpiR, Transcriptional regulators Transcription 126699993 Common - hypothetical protein CD2378 33 COG2364 COG2364, Predicted membrane protein Function unknown 126700237 Common - putative alanine racemase CD2623 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 126700929 Common - putative D-isomer specific 2-hydroxyacid dehydrogenase CD3310 229 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 126697721 Common - putative ATP/GTP hydrolase CD0149 209 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 126699126 Common - putative polysaccharide deacetylase CD1522 83 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 126700876 Common - putative polysaccharide deacetylase CD3257 86 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 126700088 Common - hypothetical protein CD2471 16 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 126700311 Common - putative amidohydrolase CD2697 170 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 126701028 Common hymA putative iron-only hydrogenase,electron-transferring subunit CD3405 157 COG1905 NuoE, NADH:ubiquinone oxidoreductase 24 kD subunit Energy production and conversion 126699571 Common - ABC transporter, permease protein CD1962 23 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126700061 Common - probale sensory protein CD2445 53 COG3476 COG3476, Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) Signal transduction mechanisms 126698762 Common - putative integrase/recombinase CD1167 9 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 126698808 Common bltD spermine/spermidine acetyltransferase CD1212 20 COG0456 RimI, Acetyltransferases General function prediction only 126700336 Common - two-component sensor histidine kinase CD2721 178 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126699805 Common pgmB beta-phosphoglucomutase CD2189 151 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 126698679 Common - conjugative transposon protein CD1092A 6 None None None 126698718 Common - nitroreductase-family protein CD1125 5 COG0778 NfnB, Nitroreductase Energy production and conversion 126698005 Common - putative drug/sodium antiporter CD0434 148 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 126700939 Common - two-component response regulator CD3320 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126697739 Common - putative sigma-54-dependent transcriptional regulator CD0167 168 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 126697975 Common - putative tRNA (Uracil-5-)-methyltransferase CD0406 159 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 126697762 Common - LysR-family transcriptional regulator CD0189 192 COG0583 LysR, Transcriptional regulator Transcription 126699825 Common - MarR-family transcriptional regulator CD2208 7 COG1846 MarR, Transcriptional regulators Transcription 126699243 Common - putative tellurite resistance protein CD1639 38 COG3853 TelA, Uncharacterized protein involved in tellurite resistance Inorganic ion transport and metabolism 126700678 Common glvC PTS system, IIbc component CD3061 53 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 126697836 Common flhF flagellar biosynthesis regulator FlhF CD0264 247 COG1419 FlhF, Flagellar GTP-binding protein Cell motility and secretion 126698903 Common dnaF DNA polymerase III PolC-type CD1305 219 COG2176 PolC, DNA polymerase III, alpha subunit (gram-positive type) DNA replication, recombination, and repair 126700296 Common nifJ pyruvate-flavodoxin oxidoreductase CD2682 115 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 126700659 Common pepI proline iminopeptidase CD3041 127 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 126698037 Common - two-component sensor histidine kinase CD0461 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126697622 Common - hypothetical protein CD0056 29 COG3688 COG3688, Predicted RNA-binding protein containing a PIN domain General function prediction only 126700918 Common - probable transporter CD3299 201 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 126700395 Common manC putative mannose-1-phosphate guanylyltransferase CD2779 161 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 126698007 Pathogen - hypothetical protein CD0435A 1 None None None 126698227 Common - putative peptidase CD0649 104 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 126700943 Common - hypothetical protein CD3324 6 None None None 126701273 Common - GntR-family transcriptional regulator CD3646 131 COG2188 PhnF, Transcriptional regulators Transcription 126698611 Common potD spermidine/putrescine ABC transporter,substrate-binding lipoprotein CD1027 139 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 126701164 Common metG methionyl-tRNA synthetase CD3540 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126698149 Common - hypothetical protein CD0571 3 None None None 126698588 Common fumB putative fumarate hydratase, subunit B CD1004 147 COG1838 FumA, Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain Energy production and conversion 126697673 Common - ABC transporter, permease protein CD0102 88 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 126697943 Common - conjugative transposon protein CD0373 6 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 126698313 Common - putative biotin/lipoate-protein ligase CD0733 79 COG0095 LplA, Lipoate-protein ligase A Coenzyme metabolism 126700888 Common pepF putative endopeptidase CD3269 86 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 126700662 Common - putative phosphosugar-binding transcriptional regulator CD3044 123 COG1737 RpiR, Transcriptional regulators Transcription 126700933 Common hydA hydrogenase CD3314 51 COG4624 COG4624, Iron only hydrogenase large subunit, C-terminal domain General function prediction only 126698791 Common spoIIIAD stage III sporulation protein AD CD1195 15 None None None 126698713 Common dhaB2 glycerol dehydratase activator CD1121 73 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 126699053 Common folE putative GTP cyclohydrolase I CD1449 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 126698843 Common - hypothetical protein CD1247 10 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 126700671 Common - two-component system response regulator CD3054 206 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126698992 Common - hypothetical protein CD1390 28 COG5505 COG5505, Predicted integral membrane protein Function unknown 126699545 Common accA acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha CD1936 179 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 126698323 Common - DeoR-family transcriptional regulator CD0743 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 126701211 Common - putative ABC transporter, permease protein CD3584 22 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126701055 Common cobD pthreonine-phosphate decarboxylase CD3432 230 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 126700640 Pathogen - hypothetical protein CD3022 1 None None None 126699739 Common - putative cations transporter CD2122 85 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 126701263 Pathogen - putative phage-related protein CD3636A 1 None None None 126697823 Common fliJ flagellar protein CD0252 3 COG2882 FliJ, Flagellar biosynthesis chaperone Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 126699574 Common - hypothetical protein CD1965 15 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 126700865 Common - putative surface protein CD3246 18 None None None 126700490 Common - putative drug/sodium antiporter CD2874 140 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 126698569 Common - putative drug/sodium antiporter CD0985 162 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 126697688 Common - 2-ketoisovalerate ferredoxin reductase CD0116 126 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 126697900 Common pcrA ATP-dependent DNA helicase CD0328 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 126699117 Common panB 3-methyl-2-oxobutanoate hydroxymethyltransferase CD1513 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 126697606 Common - putative transcription antiterminator CD0040 168 COG1221 PspF, Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain Transcription / Signal transduction mechanisms 126699207 Common - ABC transporter, permease protein CD1603 120 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 126700374 Common - putative DNA modification methylase CD2758 54 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 126700713 Common ascB1 6-phospho-beta-glucosidase CD3096 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 126698504 Common - putative DNA methylase CD0927 122 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 126698046 Common blaR putative beta-lactamase-inducing penicillin-binding protein CD0470 52 COG2602 COG2602, Beta-lactamase class D Defense mechanisms 126699878 Common - peptidase CD2261 162 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 126699974 Common - putative oligoendopeptidase CD2358 54 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 126697901 Common - putative aminopeptidase 2 CD0329 44 COG1362 LAP4, Aspartyl aminopeptidase Amino acid transport and metabolism 126698871 Common topA DNA topoisomerase I CD1274 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 126699918 Pathogen - hypothetical phage protein (partial) CD2301A 1 None None None 126698109 Common - hypothetical protein CD0530 22 None None None 126701126 Common pth peptidyl-tRNA hydrolase CD3502 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 126701102 Common upp uracil phosphoribosyltransferase CD3479 165 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 126701069 Common celM endoglucanase CD3446 77 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 126701236 Common - ABC transporter, ATP-binding protein CD3608 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 126699275 Common - putative ABC transporter, permease protein CD1670 1 None None None 126701207 Common - hypothetical protein CD3580 8 None None None 126700805 Common - probable sigma54-dependent transcriptional regulator CD3186 168 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 126699164 Common - hypothetical protein CD1560 9 None None None 126701306 Common - hypothetical protein CD3678A 185 COG0759 COG0759, Uncharacterized conserved protein Function unknown 126700075 Common - probable transporter CD2458 193 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 126701249 Common - putative ABC transporter, ATP-binding protein CD3623 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126698275 Common - probable cation transport protein CD0696 125 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 126698230 Common - GntR-family transcriptional regulator CD0652 126 COG1725 COG1725, Predicted transcriptional regulators Transcription 126698335 Pathogen - fimbrial protein (pilin) CD0755 1 COG4969 PilA, Tfp pilus assembly protein, major pilin PilA Cell motility and secretion / Intracellular trafficking and secretion 126700085 Pathogen - hypothetical protein CD2468 1 None None None 126698425 Common - putative nuclease CD0845 13 None None None 126698672 Common - hypothetical protein CD1085 7 COG0786 GltS, Na+/glutamate symporter Amino acid transport and metabolism 126697744 Common - hypothetical protein CD0172 37 COG2191 COG2191, Formylmethanofuran dehydrogenase subunit E Energy production and conversion 126700370 Common - putative signaling protein CD2754 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126699758 Common - D-alanyl-D-alanine carboxypeptidase CD2141 155 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 126699833 Pathogen - hypothetical protein CD2216 1 None None None 126698680 Common - conjugative transposon protein CD1094 8 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 126700594 Common - conserved hypothetical protein (partial) CD2972A 10 None None None 126700117 Common - putative hydrolase CD2501 145 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 126698054 Pathogen - hypothetical protein CD0477 1 None None None 126700289 Common - LysR-family transcriptional regulator CD2675 176 COG0583 LysR, Transcriptional regulator Transcription 126701218 Common pyrAA2 carbamoyl phosphate synthase small subunit CD3591 235 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 126699141 Common aspB putative oxidoreductase CD1537 196 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 126698405 Common rbr rubrerythrin CD0825 80 COG1592 COG1592, Rubrerythrin Energy production and conversion 126697907 Common - hypothetical protein CD0335 2 None None None 126698971 Common - phage protein CD1370 4 None None None 126700542 Pathogen - hypothetical protein CD2924 1 None None None 126699183 Common hom2 homoserine dehydrogenase CD1580 216 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 126700432 Common - hypothetical protein CD2816 1 None None None 126700547 Common - hypothetical protein CD2929 1 None None None 126697582 Common dnaH DNA polymerase III subunits gamma and tau CD0016 249 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 126701122 Common spoIIIF stage V sporulation protein B CD3498 47 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 126698556 Common - phage endolysin CD0972 13 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 126698743 Common - putative penicillin-binding protein CD1148 203 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 126699890 Common - DNA topoisomerase III CD2275 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 126699401 Common - putative L-threonine dehydrogenase CD1792 172 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 126700881 Common - putative phosphateABC transporter, permease protein CD3262 234 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 126699644 Common - N-carbamoyl-L-amino acid hydrolase CD2027 84 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 126700418 Common tgt queuine tRNA-ribosyltransferase CD2802 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 126700574 Common ntpB V-type ATP synthase subunit B CD2955 247 COG1156 NtpB, Archaeal/vacuolar-type H+-ATPase subunit B Energy production and conversion 126699362 Common - putative ABC transporter, permease protein CD1755 6 None None None 126700415 Common - cell surface protein CD2799 9 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126699795 Common - putative formate dehydrogenase CD2179 183 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 126698724 Common - putative transglycosylase CD1130 168 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 126698983 Common - putative transporter CD1380 177 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 126699697 Common pucC2 putative FAD-binding subunit of xanthine dehydrogenase CD2080 23 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 126699045 Common - hypothetical protein CD1441 59 COG1284 COG1284, Uncharacterized conserved protein Function unknown 126699904 Common - two-component system response regulator CD2289 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126700098 Common ung uracil-DNA glycosylase CD2481 129 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 126698755 Common cafA ribonuclease g CD1160 184 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 126698627 Common sbcC exonuclease subunit C CD1043 131 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 126700586 Common adhE aldehyde-alcohol dehydrogenase [includes: alcohol dehydrogenase and pyruvate-formate-lyase deactivase CD2966 194 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 126699223 Common - putative ABC transporter, peremase protein CD1619 5 None None None 126697923 Common - hypothetical protein CD0353 3 COG1650 COG1650, Uncharacterized protein conserved in archaea Function unknown 126700278 Common murE putative UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelat e ligase CD2664 213 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 126699496 Common - putative acetyl xylan esterase CD1885 11 None None None 126697851 Common - hypothetical protein CD0279 12 COG5015 COG5015, Uncharacterized conserved protein Function unknown 126698925 Common - radical SAM-superfamily protein CD1326 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 126698069 Common - PTS system, IIb component CD0492 40 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 126698450 Common - ABC transporter, substrate-binding lipoprotein CD0873 58 COG2984 COG2984, ABC-type uncharacterized transport system, periplasmic component General function prediction only 126699899 Common - hypothetical protein CD2284 1 None None None 126701153 Common - putative iron ABC transporter, permease protein CD3529 188 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 126699011 Common ddl D-alanine--D-alanine ligase CD1408 219 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 126700080 Common hrcA heat-inducible transcription repressor CD2463 151 COG1420 HrcA, Transcriptional regulator of heat shock gene Transcription 126698894 Pathogen - hypothetical protein CD1297 1 None None None 126700499 Common celB PTS system, lichenan-specific IIc component CD2883 38 COG1455 CelB, Phosphotransferase system cellobiose-specific component IIC Carbohydrate transport and metabolism 126699568 Common - two-component system response regulator CD1959 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126699384 Common - amino acid ABC transporter, permease protein CD1775 175 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 126697654 Common rpsH 30S ribosomal protein S8 CD0085 247 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 126699467 Pathogen - hypothetical protein CD1857A 1 None None None 126699101 Pathogen - hypothetical protein CD1497 2 None None None 126699084 Pathogen - hypothetical protein CD1480 1 None None None 126699936 Common - putative phosphoglucomutase CD2318 243 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 126698123 Common - ornithine cyclodeaminase CD0544 101 COG2423 COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog Amino acid transport and metabolism 126699946 Common - putative sigma-54 interacting transcription antiterminator CD2328 166 COG1221 PspF, Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain Transcription / Signal transduction mechanisms 126700718 Common - PTS system, IIbc component CD3101 49 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 126701240 Common - hypothetical protein CD3614 29 COG5483 COG5483, Uncharacterized conserved protein Function unknown 126698060 Common - ABC transporter, permease protein CD0483 6 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126698187 Common - hypothetical protein CD0609 32 COG2320 GrpB, Uncharacterized conserved protein Function unknown 126700960 Common - putative conjugative transposon antirestriction protein CD3340 17 None None None 126700195 Common - putative ATP/GTP-binding protein CD2576 163 COG1162 COG1162, Predicted GTPases General function prediction only 126698222 Common - two-component sensor histidine kinase CD0644 222 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 126701280 Common - hypothetical protein CD3653 5 COG3935 DnaD, Putative primosome component and related proteins DNA replication, recombination, and repair 126699611 Common ispD major intracellular serine protease CD2000 151 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 126699546 Common accD acetyl-coenzyme A carboxylase carboxyl transferase subunit beta CD1937 221 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 126699706 Common - probable amidohydrolase CD2089 178 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 126700101 Common - putative aminotransferase CD2484 232 COG1168 MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities Amino acid transport and metabolism 126700443 Common - putative MarR-family regulatory protein CD2827 47 COG1846 MarR, Transcriptional regulators Transcription 126700437 Common - hypothetical protein CD2821 11 COG3314 COG3314, Uncharacterized protein conserved in bacteria Function unknown 126698498 Pathogen - hypothetical protein CD0921 1 None None None 126701043 Common hemD porphyrin biosynthesis protein CD3420 205 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 126700258 Common spoIIGA sporulation sigma-E factor processing peptidase CD2644 9 None None None 126698687 Common - putative conjugative transposon protein CD1100 3 None None None 126698570 Common - putative 30S ribosomal protein S1 CD0986 218 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 126700831 Common - hypothetical protein CD3212 14 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 126699417 Common - putative pyridoxal-dependent decarboxylase CD1808 218 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 126700505 Pathogen - hypothetical protein CD2889 1 None None None 126697993 Common - hypothetical protein CD0422 15 None None None 126700772 Common - putative phage repressor CD3154 12 COG1396 HipB, Predicted transcriptional regulators Transcription 126700412 Common - cell surface protein CD2796 10 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126699675 Pathogen - hypothetical protein CD2058 1 None None None 126697950 Common - putative conjugative transposon replication initiation factor CD0381 8 COG2946 COG2946, Putative phage replication protein RstA DNA replication, recombination, and repair 126699637 Common clpB chaperone CD2020 219 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 126700317 Common - conserved hypothetical pentapeptide repeat protein CD2703 32 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 126698459 Common glgC glucose-1-phosphate adenylyltransferase CD0882 223 COG0448 GlgC, ADP-glucose pyrophosphorylase Carbohydrate transport and metabolism 126700070 Common - hypothetical protein CD2453 5 COG1857 COG1857, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 126700838 Common hslO chaperonin CD3219 116 COG1281 COG1281, Disulfide bond chaperones of the HSP33 family Posttranslational modification, protein turnover, chaperones 126699589 Common - ABC transporter, permease protein CD1980 171 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 126700358 Common dtd putative D-tyrosyl-tRNA protein CD2743 139 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 126699127 Common - hypothetical protein CD1523 113 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 126699718 Common - putative FAD-binding subunit of oxidoreductase CD2101 33 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 126697639 Common rpsJ 30S ribosomal protein S10 CD0072 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 126699602 Pathogen - hypothetical protein CD1992A 1 None None None 126698376 Common - LacI-family transcriptional regulator CD0796 103 COG1609 PurR, Transcriptional regulators Transcription 126698635 Pathogen - putative ABC transporter, permease protein CD1051 1 None None None 126700909 Common - putative protein translocase CD3290 8 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 126697959 Common bglG beta-glucoside bgl operon transcription antiterminator CD0390 29 COG3711 BglG, Transcriptional antiterminator Transcription 126699040 Common - hypothetical protein CD1436 36 COG2720 COG2720, Uncharacterized vancomycin resistance protein Defense mechanisms 126698778 Common fabG 3-oxoacyl-[acyl-carrier protein] reductase CD1182 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 126700486 Common kdgT 2-keto-3-deoxygluconate permease CD2870 27 None None None 126700949 Common - putative transposon-related DNA-binding protein CD3330 4 COG1476 COG1476, Predicted transcriptional regulators Transcription 126700459 Common - putative zinc-binding dehydrogenase CD2843 136 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 126700517 Common - putative phage tail protein CD2900 9 COG3299 XkdT, Uncharacterized homolog of phage Mu protein gp47 Function unknown 126700408 Common secA2 preprotein translocase SecA subunit CD2792 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 126698691 Pathogen - hypothetical protein CD1103A 1 None None None 126701141 Common purR purine operon repressor CD3517 74 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 126699192 Common - putative ribose ABC transporter, permease protein CD1588 113 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 126700657 Common - hypothetical protein CD3039 29 COG0714 COG0714, MoxR-like ATPases General function prediction only 126697662 Common map1 methionine aminopeptidase CD0092 249 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 126698272 Common - MerR-family transcriptional regulator CD0693 92 COG0789 SoxR, Predicted transcriptional regulators Transcription 126698019 Common oraS D-ornithine aminomutase S component CD0445 7 None None None 126700791 Common gpmI phosphoglyceromutase CD3171 127 COG0696 GpmI, Phosphoglyceromutase Carbohydrate transport and metabolism 126700991 Common - putative conjugative transposon recombinase CD3370 82 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 126697569 Common - putative RNA-binding mediating protein CD0003 59 COG2501 COG2501, Uncharacterized conserved protein Function unknown 126697711 Common - glycosylasparaginase CD0139 84 COG1446 COG1446, Asparaginase Amino acid transport and metabolism 126698162 Common - putative signaling protein CD0584 174 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126699815 Common - putative subunit of oxidoreductase CD2199 116 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 126699331 Common - AraC-family transcriptional regulator CD1725 58 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 126700300 Pathogen - hypothetical protein CD2686 1 None None None 126699415 Common scrK putative fructokinase CD1806 181 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 126700563 Common - phage protein CD2945 12 None None None 126698881 Common - hypothetical protein CD1284 9 None None None 126698237 Common tcdD putative transcriptional regulator CD0659 2 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 126698484 Common - putative phage regulatory protein CD0907A 2 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 126699773 Pathogen - hypothetical protein CD2157 1 None None None 126697773 Pathogen - hypothetical protein CD0202 1 None None None 126699047 Common - hypothetical protein CD1443 72 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 126700983 Common - ABC transporter, permease protein CD3363 27 COG4587 COG4587, ABC-type uncharacterized transport system, permease component General function prediction only 126698180 Common - putative plasmid-related protein CD0602 2 None None None 126700045 Common - putative oxidoreductase ferredoxin subunit CD2429A 44 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 126698211 Common - hypothetical protein CD0633 36 COG4335 COG4335, DNA alkylation repair enzyme DNA replication, recombination, and repair 126699628 Pathogen - putative plasmid conserved protein (partial) CD2010B 1 None None None 126698620 Common - cell surface protein (putative N-acetylmuramoyl-L-alanine amidase) CD1036 174 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 126698608 Common potA spermidine/putrescine ABC transporter,ATP-binding protein CD1024 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 126699092 Common - putative transcriptional regulator CD1488 91 COG2378 COG2378, Predicted transcriptional regulator Transcription 126701078 Common - putative exported carboxy-terminal processing protease CD3455 188 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 126699420 Common - putative two-component system response regulator (partial) CD1812 3 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 126699665 Common - RpiR-family transcriptional regulator CD2048 98 COG1737 RpiR, Transcriptional regulators Transcription 126700694 Common - phosphosugar-binding transcriptional regulator CD3077 15 COG1737 RpiR, Transcriptional regulators Transcription 126699324 Common - hypothetical protein CD1717 34 COG3535 COG3535, Uncharacterized conserved protein Function unknown 126699960 Common sucD succinate-semialdehyde dehydrogenase (NAD(P)+) CD2342 184 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 126698657 Common - putative aminotransferase CD1070 209 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 126701110 Common rpmE 50S ribosomal protein L31 CD3486A 158 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 126701134 Common - putaive membrane protein CD3510 1 COG4972 PilM, Tfp pilus assembly protein, ATPase PilM Cell motility and secretion / Intracellular trafficking and secretion 126697944 Common - conjugative transposon protein CD0374 17 COG0433 COG0433, Predicted ATPase General function prediction only 126699858 Common nanE N-acetylmannosamine-6-phosphate 2-epimerase CD2241 47 COG3010 NanE, Putative N-acetylmannosamine-6-phosphate epimerase Carbohydrate transport and metabolism 126700340 Common - putative UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase CD2725 25 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 126701253 Common - putative dihydrodipicolinate synthase CD3627 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 126699712 Pathogen - hypothetical protein CD2095 1 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 126700439 Common - hypothetical protein CD2823 8 None None None 126698782 Common - putative sigma-54 dependent transcriptional regulator CD1186 168 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 126700262 Common - hypothetical protein CD2648 25 COG3879 COG3879, Uncharacterized protein conserved in bacteria Function unknown 126700004 Common - putative beta-lactamase inducer CD2389 22 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 126701022 Common - hypothetical protein CD3399 98 COG0391 COG0391, Uncharacterized conserved protein Function unknown 126700770 Common - putative phage transcriptional regulator CD3152A 21 COG1476 COG1476, Predicted transcriptional regulators Transcription 126700271 Pathogen - hypothetical protein CD2657 1 None None None 126698667 Pathogen - putative lipoprotein CD1080 1 None None None 126699177 Pathogen - hypothetical protein CD1574 7 None None None 126700453 Common - hypothetical protein CD2837 24 COG3949 COG3949, Uncharacterized membrane protein Function unknown 126700209 Common - hypothetical protein CD2589 137 COG1561 COG1561, Uncharacterized stress-induced protein Function unknown 126698630 Common pepT peptidase T CD1046 63 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 126699907 Pathogen - hypothetical protein CD2292 1 None None None 126700879 Common phoU putative phosphate transport system protein CD3260 198 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 126697719 Common - putative riboflavin transporter CD0147 21 COG3601 COG3601, Predicted membrane protein Function unknown 126698744 Common minC septum site-determining protein CD1149 51 COG0850 MinC, Septum formation inhibitor Cell division and chromosome partitioning 126700344 Common - putative regulator of the sigma(E) factor CD2729 16 COG3086 RseC, Positive regulator of sigma E activity Signal transduction mechanisms 126700762 Common - putative serine-aspartate-rich surface anchored fibrinogen-binding protein CD3145 71 None None None 126699512 Pathogen - putative transposase (partial) CD1902 2 None None None 126699535 Common eutQ putative ethanolamine/propanediol utilization protein CD1925 19 COG4766 EutQ, Ethanolamine utilization protein Amino acid transport and metabolism 126700471 Common - putative oxidoreductase CD2855 163 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 126698020 Common oraE D-ornithine aminomutase E component CD0446 23 COG5012 COG5012, Predicted cobalamin binding protein General function prediction only 126700854 Pathogen - hypothetical protein CD3234 1 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 126700156 Common elaC ribonuclease Z CD2539 113 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 126700152 Common - two-component sensor histidine kinase CD2535 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126698207 Common - putative transcriptional regulator CD0629 96 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 126698025 Common - hypothetical protein CD0451 7 None None None 126698985 Common glpK2 glycerol kinase CD1382 178 COG0554 GlpK, Glycerol kinase Energy production and conversion 126698261 Common - putative sodium:solute symporter CD0682 148 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 126700235 Common - hypothetical protein CD2621 31 None None None 126698704 Common - hypothetical protein CD1112 4 None None None 126698590 Common - conserved acetyltransferase CD1006 10 COG3153 COG3153, Predicted acetyltransferase General function prediction only 126698169 Common - putative cation transporting ATPase CD0591 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 126698788 Common spoIIIAA stage III sporulation protein AA CD1192 32 COG3854 SpoIIIAA, ncharacterized protein conserved in bacteria Function unknown 126697705 Common - putative phosphoribosyl transferase (putative competence protein) CD0133 77 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 126697965 Common hadI activator of 2-hydroxyisocaproyl-CoA dehydratase CD0396 65 COG1924 COG1924, Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) Lipid metabolism 126698247 Common - two-component response regulator CD0668 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126699287 Common - TetR-family transcriptional regulator CD1681 12 COG1309 AcrR, Transcriptional regulator Transcription 126701287 Common - hypothetical protein CD3660 8 COG4241 COG4241, Predicted membrane protein Function unknown 126700202 Common - hypothetical protein CD2583 31 COG1852 COG1852, Uncharacterized conserved protein Function unknown 126701177 Pathogen - hypothetical protein CD3551B 1 None None None 126700745 Common - PTS system, IIabc component CD3127 43 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 126700334 Common - polysaccharide deacetylase CD2719 105 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 126698560 Common - hypothetical protein CD0976 2 COG1952 SecB, Preprotein translocase subunit SecB Intracellular trafficking and secretion 126699779 Common - putative RNA-binding protein CD2163 206 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126698593 Common - GntR-family transcriptional regulator CD1009 129 COG2188 PhnF, Transcriptional regulators Transcription 126700555 Pathogen - hypothetical protein CD2937 1 None None None 126699293 Pathogen - putative lipoprotein CD1687 1 None None None 126699003 Common - hypothetical protein CD1401 18 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 126700134 Pathogen - hypothetical protein CD2517A 1 None None None 126698088 Pathogen orf9 putative conjugative transposon regulatory protein CD0509 3 COG1476 COG1476, Predicted transcriptional regulators Transcription 126698896 Common - MarR-family transcriptional regulator CD1299 12 COG1846 MarR, Transcriptional regulators Transcription 126701295 Common - hypothetical protein CD3667 26 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 126699221 Common - GntR-family transcriptional regulator CD1617 15 COG1725 COG1725, Predicted transcriptional regulators Transcription 126700851 Common hpt hypoxanthine phosphoribosyltransferase CD3231 154 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 126699981 Common - hypothetical protein CD2366 3 None None None 126698693 Common - hypothetical protein CD1104A 1 COG1571 COG1571, Predicted DNA-binding protein containing a Zn-ribbon domain General function prediction only 126700967 Pathogen - hypothetical protein CD3347 1 None None None 126700161 Common - hypothetical protein CD2544 1 None None None 126697913 Common - hypothetical protein CD0341 5 None None None 126699068 Common - two-component response regulator CD1464 220 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126700012 Common - putative exonuclease CD2397 9 COG5018 KapD, Inhibitor of the KinA pathway to sporulation, predicted exonuclease General function prediction only 126700427 Common - hypothetical protein CD2811 19 COG3395 COG3395, Uncharacterized protein conserved in bacteria Function unknown 126698664 Common - PTS system, IIc component CD1077 39 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 126701000 Common mgtA magnesium transporting ATPase, P-type 1 CD3377 230 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 126699543 Common - hypothetical protein CD1934 20 COG3603 COG3603, Uncharacterized conserved protein Function unknown 126698041 Common - RpiR-family transcriptional regulator CD0465 32 COG1737 RpiR, Transcriptional regulators Transcription 126698135 Common - putative endonuclease CD0556 5 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 126700893 Common feoB3 putative ferrous iron transport protein B CD3274 156 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 126699771 Common - biotin synthase CD2155 39 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 126699669 Pathogen - putative lipoprotein CD2052 1 None None None 126699111 Pathogen - hypothetical protein CD1507A 1 None None None 126700828 Common - PadR-family transcriptional regulator CD3209 45 COG1695 COG1695, Predicted transcriptional regulators Transcription 126699490 Common - hypothetical protein CD1878 3 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 126698106 Common - metallo-beta-lactamase superfamily hydrolase CD0527 42 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 126700051 Common recO DNA repair protein CD2435 69 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 126698481 Common - phage protein CD0905 18 COG5185 HEC1, Protein involved in chromosome segregation, interacts with SMC proteins Cell division and chromosome partitioning 126699288 Common iunH inosine-uridine preferring nucleoside hydrolase CD1682 87 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 126697572 Common gyrA DNA gyrase subunit A CD0006 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 126697724 Common gcp probable glycoprotease CD0152 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 126700173 Common - phosphotransferase system, B component CD2555 30 COG3414 SgaB, Phosphotransferase system, galactitol-specific IIB component Carbohydrate transport and metabolism 126700241 Common - hypothetical protein CD2627 37 COG3830 COG3830, ACT domain-containing protein Signal transduction mechanisms 126699845 Common - hypothetical protein CD2228 13 None None None 126698757 Common - hypothetical protein CD1162 18 COG2868 COG2868, Predicted ribosomal protein Translation, ribosomal structure and biogenesis 126698446 Common modA putative molybdenum ABC transporter,substrate-binding protein CD0869 161 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 126699439 Common - putative cation transport-related, membrane protein CD1831 106 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 126699886 Common - putative transcriptional antiterminator CD2271 37 COG3711 BglG, Transcriptional antiterminator Transcription 126701226 Common - two-component sensor histidine kinase CD3599 222 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 126697629 Common rplA 50S ribosomal protein L1 CD0062 221 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 126699314 Common - putative C4-dicarboxylate anaerobic carrier CD1707 38 COG1288 COG1288, Predicted membrane protein Function unknown 126699947 Common tal1 putative translaldolase CD2329 168 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 126699156 Common hisA putative 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylidene amino] imidazole-4-carboxamide isomerase CD1552 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 126698130 Common sleC putative spore cortex-lytic enzyme pre-pro-form (putative spore peptidoglycan hydrolase) CD0551 4 COG3409 COG3409, Putative peptidoglycan-binding domain-containing protein Cell envelope biogenesis, outer membrane 126698732 Common rnfD electron transport complex protein CD1138 76 COG4658 RnfD, Predicted NADH:ubiquinone oxidoreductase, subunit RnfD Energy production and conversion 126699965 Common - putative Xaa-Pro dipeptidase CD2347 248 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 126697970 Common etfA1 electron transfer flavoprotein alpha-subunit CD0401 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 126698836 Common vanZ putative teicoplanin resistance protein CD1240 3 COG4767 VanZ, Glycopeptide antibiotics resistance protein Defense mechanisms 126699132 Common - ABC transporter, ATP-binding protein CD1528 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126698939 Common - putative galactose-1-phosphate uridylyltransferase CD1340 79 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 126698878 Common trmU putative tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase CD1281 217 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 126698542 Pathogen - hypothetical protein CD0958 1 None None None 126700321 Common - putative transport protein CD2707 37 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 126697801 Common - putative flagellar biosynthesis protein CD0230 2 None None None 126700060 Common - putative sigma 54 modulation protein CD2444 137 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 126698148 Common - putative outer membrane lipoprotein CD0570 101 COG1744 Med, Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein General function prediction only 126700191 Common - putative nitroreductase CD2572 64 COG0778 NfnB, Nitroreductase Energy production and conversion 126698152 Common thrS threonyl-tRNA synthetase CD0574 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126700329 Common gtaB UTP--glucose-1-phosphate uridylyltransferase CD2715 232 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 126699876 Common - hypothetical protein CD2259 18 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 126699118 Common - hypothetical protein CD1514 41 COG5495 COG5495, Uncharacterized conserved protein Function unknown 126699273 Common - hypothetical protein CD1668 1 None None None 126701131 Pathogen - putative type IV pilin CD3507 1 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 126701062 Common cobT nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase CD3439 118 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 126700528 Common - phage protein CD2910 6 None None None 126700539 Common - phage portal protein CD2921 11 None None None 126698940 Common exoA putative exodeoxyribonuclease CD1341 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 126701018 Common pfkA 6-phosphofructokinase CD3395 160 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 126700028 Common - hypothetical protein CD2413 36 COG4091 COG4091, Predicted homoserine dehydrogenase Amino acid transport and metabolism 126700115 Common - hypothetical protein CD2499 2 None None None 126698739 Common radC DNA repair protein CD1144 179 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 126700687 Common - PTS system, IIc component CD3070 36 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 126697617 Common gltX glutamyl-tRNA synthetase CD0051 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 126700971 Common clpP2 ATP-dependent Clp protease proteolytic subunit CD3351 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 126700005 Common - putative beta-lactamase repressor CD2390 19 COG3682 COG3682, Predicted transcriptional regulator Transcription 126697985 Common - hypothetical protein CD0415 4 None None None 126700981 Common - putative multidrug efflux protein CD3361 100 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 126698833 Pathogen - hypothetical protein CD1236 1 None None None 126698242 Common cdd1 hypothetical protein CD0664A 9 None None None 126697746 Common - putative lipoprotein CD0173 69 COG2843 PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) Cell envelope biogenesis, outer membrane 126699700 Common - D-hydantoinase CD2083 196 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 126698340 Common - Ca2+/Na+ antiporter CD0760 114 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 126698300 Common folD FolD bifunctional protein CD0720 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 126699688 Common - hypothetical protein CD2071 13 None None None 126700211 Common ltaE low-specificity L-threonine aldolase CD2591 116 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 126697794 Common purH bifunctional purine biosynthesis protein CD0223 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 126699128 Common - putative rubrerythrin CD1524 20 COG1592 COG1592, Rubrerythrin Energy production and conversion 126699303 Common ribH riboflavin synthase beta chain (6,7-dimethyl-8-ribityllumazine synthase) CD1697 229 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 126700588 Common spoVFB dipicolinate synthase subunit B CD2967 29 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 126700599 Common - hypothetical protein CD2978 91 COG1203 COG1203, Predicted helicases General function prediction only 126698869 Common - putative competence protein (putative magnesium chelatase) CD1272 198 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 126698642 Common hbd 3-hydroxybutyryl-CoA dehydrogenase CD1058 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 126699514 Common - ABC transporter, permease protein CD1904 156 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 126699430 Common bcp putative thiol peroxidase (bacterioferritin comigratory protein) CD1822 229 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 126699863 Common - hypothetical protein CD2245A 1 None None None 126700386 Common - putative capsular polysaccharide biosynthesis glycosyl transferase CD2770 221 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 126698289 Common - hypothetical protein CD0710 65 COG1683 COG1683, Uncharacterized conserved protein Function unknown 126698640 Common etfA2 electron transfer flavoprotein alpha-subunit CD1056 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 126700283 Common - putative Na(+)/H(+) antiporter CD2669a 103 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 126700034 Common - AraC-family transcriptional regulator CD2419 130 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 126700143 Common gbeA glycogen branching enzyme CD2526 160 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 126700232 Common ileS isoleucyl-tRNA synthetase CD2618 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126699444 Common aroC chorismate synthase CD1835 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 126697814 Common - hypothetical protein CD0243 16 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 126698370 Common - putative NUDIX-family hydrolase CD0790 6 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 126700180 Common - hypothetical protein CD2562 29 COG1302 COG1302, Uncharacterized protein conserved in bacteria Function unknown 126701243 Common - hypothetical protein CD3617 5 COG5504 COG5504, Predicted Zn-dependent protease Posttranslational modification, protein turnover, chaperones 126699924 Common - hypothetical protein CD2306 2 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 126699597 Pathogen - hypothetical protein CD1989 1 None None None 126700846 Common dapB1 dihydrodipicolinate reductase CD3226 215 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 126699473 Common - putative conjugative transposon DNA recombination protein CD1862 59 COG4646 COG4646, DNA methylase Transcription / DNA replication, recombination, and repair 126699162 Common sigV RNA polymerase sigma factor CD1558 156 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 126699480 Common - putative conjugative transposon mobilization protein CD1869 9 COG5022 COG5022, Myosin heavy chain Cytoskeleton 126697980 Pathogen - hypothetical protein CD0411 3 None None None 126698032 Common - putative antibiotic resistance ABC transporter,ATP-binding protein CD0456 246 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 126699360 Common - ABC transporter, ATP-binding protein CD1753 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126699764 Common - putative serine/threonine protein kinase CD2148 109 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 126698647 Pathogen - hypothetical protein CD1063 1 None None None 126698517 Common - hypothetical protein CD0938 1 None None None 126699020 Common - putative ATP-binding protein CD1417 53 COG2102 COG2102, Predicted ATPases of PP-loop superfamily General function prediction only 126699744 Pathogen - hypothetical protein CD2127 1 None None None 126700958 Common - conjugative transposon conserved hypothetical protein CD3338 16 COG0433 COG0433, Predicted ATPase General function prediction only 126699921 Common - putative regulatory protein CD2304 1 COG3682 COG3682, Predicted transcriptional regulator Transcription 126700856 Common - hypothetical protein CD3236 13 COG0730 COG0730, Predicted permeases General function prediction only 126699457 Pathogen - putative conjugative transposon protein CD1848 2 None None None 126699522 Common eutA reactivating factor for ethanolamine ammonia lyase CD1912 17 COG4819 EutA, Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition Amino acid transport and metabolism 126698173 Common - hypothetical protein CD0595 17 COG1475 Spo0J, Predicted transcriptional regulators Transcription 126699200 Common map2 methionine aminopeptidase CD1596 246 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 126698377 Common - putative hydroxymethylglutaryl-CoA lyase CD0797 196 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 126698165 Common - hypothetical protein CD0587 9 None None None 126700635 Common - PTS system, IIa component CD3015 145 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 126701033 Common uvrC excinuclease ABC subunit C CD3410 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 126699547 Common accC biotin carboxylase (acetyl-CoA carboxylase subunit A) CD1938 237 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 126698862 Common - putative regulatory protein CD1265 49 COG1329 COG1329, Transcriptional regulators, similar to M. xanthus CarD Transcription 126701168 Common - AsnC-family transcriptional regulator CD3544 160 COG1522 Lrp, Transcriptional regulators Transcription 126699121 Common feoB2 putative ferrous ion transport protein CD1517 165 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 126698193 Common - TetR-family transcriptional regulator CD0615 7 COG1309 AcrR, Transcriptional regulator Transcription 126699501 Common - hypothetical protein CD1890 4 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 126700606 Common - ABC transporter, ATP-binding protein CD2985 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126699646 Pathogen - putative lipoprotein CD2029 2 None None None 126699226 Common - putative lipoprotein CD1622 12 COG3212 COG3212, Predicted membrane protein Function unknown 126699253 Common - putative iron compound ABC transporter,ATP-binding protein CD1649 249 COG4604 CeuD, ABC-type enterochelin transport system, ATPase component Inorganic ion transport and metabolism 126700924 Common clpP1 ATP-dependent Clp protease proteolytic subunit CD3305 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 126698463 Common - putative alpha-amylase CD0886 160 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 126699478 Common - conjugative transposon conserved hypothetical protein CD1867 3 None None None 126698949 Common - putative lantibiotic ABC transporter, permease protein CD1350 6 None None None 126697849 Common - hypothetical protein CD0277 7 None None None 126698581 Common - putative signaling protein CD0997 194 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126698821 Common deoA pyrimidine-nucleoside phosphorylase CD1225 123 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 126699732 Common - putative copper-transporting P-type ATPase CD2115 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 126697858 Pathogen - putative PTS system, IIa component CD0286 1 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 126697807 Common fliS2 flagellar protein CD0236 19 COG1516 FliS, Flagellin-specific chaperone FliS Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 126699368 Pathogen - conserved hypothetical protein (partial) CD1759A 1 None None None 126699213 Pathogen - hypothetical protein CD1609 1 None None None 126697760 Common pyrE orotate phosphoribosyltransferase CD0187 75 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 126698125 Common - hypothetical protein CD0546 9 COG5523 COG5523, Predicted integral membrane protein Function unknown 126698846 Common smc chromosome partition protein CD1250 219 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 126699748 Common - putative regulatory protein CD2132 9 COG3655 COG3655, Predicted transcriptional regulator Transcription 126698282 Common - protease CD0703 141 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 126698399 Common - putative transcription antiterminator CD0819 29 COG3711 BglG, Transcriptional antiterminator Transcription 126700814 Common - putative excinuclease ABC subunit A CD3195 242 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 126701003 Common - putative cell wall hydrolase CD3380 130 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 126697896 Common cbiM putative cobalt transport protein CD0324 83 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 126700384 Common - putative cell-wall hydrolase CD2768 137 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 126699115 Common - hypothetical protein CD1511 5 None None None 126699166 Common - hypothetical protein CD1562 144 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 126700546 Pathogen - hypothetical protein CD2928 1 None None None 126697769 Common guaA bifunctional GMP synthase/glutamine amidotransferase protein CD0198 239 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 126699524 Common eutC ethanolamine ammonia-lyase small subunit CD1914 52 COG4302 EutC, Ethanolamine ammonia-lyase, small subunit Amino acid transport and metabolism 126698390 Common floX putative flavodoxin CD0810 53 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 126698930 Common sip3 signal peptidase I CD1331 183 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 126699823 Common aldH aldehyde dehydrogenase CD2206 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 126699595 Common - cell surface protein CD1987 7 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126697905 Common ppaC putative manganese-dependent inorganic pyrophosphatase CD0333 53 COG1227 PPX1, Inorganic pyrophosphatase/exopolyphosphatase Energy production and conversion 126697604 Common acoC E2 component of acetoin dehydrogenase enzyme system (dihydrolipoamide acetyltransferase) CD0038 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 126699001 Common - putative muramoyltetrapeptide carboxypeptidase CD1399 86 COG1619 LdcA, Uncharacterized proteins, homologs of microcin C7 resistance protein MccF Defense mechanisms 126700825 Pathogen - hypothetical protein CD3206 1 None None None 126698506 Common - phage protein CD0929 8 None None None 126698567 Common - putative hydrolase CD0983 14 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 126699809 Common - cell surface protein CD2193 15 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126698529 Common - putative phage major capsid protein CD0948 4 None None None 126701247 Common - hypothetical protein CD3621 35 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 126697642 Common rplW 50S ribosomal protein L23 CD0075 212 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 126699508 Common - putative phage-related cell wall hydrolase (endolysin) CD1898 28 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 126700685 Common - PTS system, IIb component CD3068 41 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 126701209 Common - putative pseudouridylate synthase CD3582 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 126698920 Common - hypothetical protein CD1321 14 COG1873 COG1873, Uncharacterized conserved protein Function unknown 126700493 Common fhuB putative ferrichrome ABC transporter, permease protein CD2877 191 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 126699818 Common - lactose permease CD2201 38 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 126700372 Common ptsH PTS system, phosphocarrier protein CD2756 159 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 126700287 Common appB oligopeptide ABC transporter, permease protein CD2673 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 126698250 Common - putative glyoxalase CD0671 9 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 126698403 Common - putative lantibiotic ABC transporter, permease protein CD0823 2 COG4200 COG4200, Uncharacterized protein conserved in bacteria Function unknown 126698277 Common - putative RNA methylase CD0698 210 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 126698057 Common spaG putative lantibiotic ABC transporter, permease protein CD0480 4 COG4200 COG4200, Uncharacterized protein conserved in bacteria Function unknown 126698923 Common ftsK putative DNA translocase CD1324 199 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 126698364 Common - putative N-acetylmuramoyl-L-alanine amidase CD0784 135 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 126699797 Common - putative aromatic compounds hydrolase CD2181 103 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 126699065 Common - hypothetical protein CD1461 7 COG4194 COG4194, Predicted membrane protein General function prediction only 126699354 Common add adenosine deaminase CD1747 114 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 126701120 Common hupA DNA-binding protein HU CD3496 211 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 126700806 Common tdcF putative regulatory endoribonuclease CD3187 186 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 126699143 Common - ABC transporter, ATP-binding protein CD1539 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126700140 Common - putative metal dependent phosphohydrolase CD2523 43 COG1713 COG1713, Predicted HD superfamily hydrolase involved in NAD metabolism Coenzyme metabolism 126699604 Common - hypothetical protein CD1994 18 COG5658 COG5658, Predicted integral membrane protein Function unknown 126699831 Common - putative regulatory protein CD2214 37 COG1476 COG1476, Predicted transcriptional regulators Transcription 126699185 Common hisD histidinol dehydrogenase CD1582 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 126700091 Common - hypothetical protein CD2474 52 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 126700187 Common - PTS system, IIC component CD2568 67 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 126701222 Common - aminopeptidase CD3595 56 COG2309 AmpS, Leucyl aminopeptidase (aminopeptidase T) Amino acid transport and metabolism 126699460 Pathogen - putative conjugal transfer protein (putative single-stranded dna binding protein) CD1851 2 None None None 126700110 Common selB selenocysteine-specific elongation factor CD2493 249 COG3276 SelB, Selenocysteine-specific translation elongation factor Translation, ribosomal structure and biogenesis 126699309 Pathogen thiS putative thiamine biosynthesis protein CD1702A 1 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 126700628 Common - hypothetical protein CD3007 16 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 126699008 Common - ABC transporter, ATP-binding protein CD1405 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 126699838 Common - putative plasmid-related protein (partial) CD2221 5 None None None 126700308 Pathogen - hypothetical protein CD2694 1 COG3339 COG3339, Uncharacterized conserved protein Function unknown 126700356 Common - coproporphyrinogen III oxidase CD2741 185 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 126700676 Pathogen - hypothetical protein CD3059 1 None None None 126700067 Common prmA ribosomal protein L11 methyltransferase CD2450 144 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 126701014 Pathogen - hypothetical protein CD3391A 1 None None None 126699043 Common - hypothetical protein CD1439 7 COG1380 COG1380, Putative effector of murein hydrolase LrgA General function prediction only 126699737 Common - putative 2-nitropropane dioxygenase CD2120 135 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 126700616 Common nrdE ribonucleoside-diphosphate reductase alpha chain CD2995 214 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 126699498 Common - RNA polymerase sigma factor CD1887 134 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 126700294 Common - putative permease CD2680 50 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 126698003 Common - ABC transporter, ATP-binding/permease protein CD0432 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 126700280 Common crr PTS system, glucose-specific IIa component CD2666 60 COG2190 NagE, Phosphotransferase system IIA components Carbohydrate transport and metabolism 126697750 Common - cyclopropane-fatty-acyl-phospholipid synthase CD0177 141 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 126698115 Common cheW chemotaxis protein CD0536 122 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 126699619 Common - putative topoisomerase (partial) CD2006 18 COG1933 COG1933, Archaeal DNA polymerase II, large subunit DNA replication, recombination, and repair 126701096 Common atpE ATP synthase C chain CD3473 34 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 126699248 Common - putative transcriptional regulator CD1644 116 COG1396 HipB, Predicted transcriptional regulators Transcription 126700365 Pathogen agrD autoinducer prepeptide CD2749A 1 None None None 126700204 Common def2 peptide deformylase 2 CD2585 207 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 126698452 Common - ABC transporter, permease protein CD0875 122 COG4120 COG4120, ABC-type uncharacterized transport system, permease component General function prediction only 126699561 Common - LysR-family transcriptional regulator CD1952 193 COG0583 LysR, Transcriptional regulator Transcription 126699469 Common - conjugative transposon DNA topoisomerase CD1859 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 126697675 Common rplM 50S ribosomal protein L13 CD0104 226 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 126697878 Common - hypothetical protein CD0306 5 None None None 126697810 Common fliC flagellin subunit CD0239 122 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 126699441 Common - 3-deoxy-7-phosphoheptulonate synthase CD1832 187 COG2876 AroA, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 126699897 Common - PTS system, IIbc component CD2282 37 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 126699013 Common - putative hydrolase CD1410 104 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 126697737 Common - putative amino acid transporter CD0165 154 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 126699768 Common - putative glutamyl-aminopeptidase CD2152 81 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 126701175 Common speA putative arginine decarboxylase CD3551 85 COG1982 LdcC, Arginine/lysine/ornithine decarboxylases Amino acid transport and metabolism 126697866 Common - putative ABC transporter, permease protein CD0294 4 None None None 126697834 Common flhB bifunctional flagellar biosynthesis protein FliR/FlhB CD0262 130 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 126700935 Pathogen - hypothetical protein CD3315A 1 None None None 126698520 Pathogen - hypothetical protein CD0940A 1 None None None 126698857 Common - branched chain amino acid transport system carrier protein CD1260 50 COG1114 BrnQ, Branched-chain amino acid permeases Amino acid transport and metabolism 126697589 Common ctsR transcriptional regulator CD0023 22 COG4463 CtsR, Transcriptional repressor of class III stress genes Transcription 126700492 Common fhuG putative ferrichrome ABC transporter, permease protein CD2876 192 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 126698198 Common - hypothetical protein CD0620 7 None None None 126698972 Common - phage protein CD1371 31 COG3299 XkdT, Uncharacterized homolog of phage Mu protein gp47 Function unknown 126700030 Pathogen - hypothetical protein CD2415 1 COG4578 GutM, Glucitol operon activator Transcription 126698355 Common spoVAE stage V sporulation protein AE CD0775 15 None None None 126700078 Common dnaK chaperone protein CD2461 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 126700397 Common mviN putative transmembrane virulence factor MviN family protein CD2781 186 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 126699098 Common - putative transcriptional regulator CD1494 106 COG3837 COG3837, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 126700026 Common - hypothetical protein CD2411 112 COG1806 COG1806, Uncharacterized protein conserved in bacteria Function unknown 126699051 Common pabC putative aminodeoxychorismate lyase CD1447 145 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 126700579 Common ntpK V-type ATP synthase subunit K CD2959 18 None None None 126700042 Common - putative oxidoreductase subunit CD2427 74 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 126700664 Common murQ N-acetylmuramic acid-6-phosphate etherase CD3046 93 COG2103 COG2103, Predicted sugar phosphate isomerase General function prediction only 126701269 Common - putative selenocysteine synthase CD3642 75 COG1921 SelA, Selenocysteine synthase [seryl-tRNASer selenium transferase] Amino acid transport and metabolism 126698293 Common - hypothetical protein CD0714 22 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 126699408 Common - tellurium resistance protein CD1799 29 COG2310 TerZ, Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 Signal transduction mechanisms 126700379 Pathogen - putative lipoprotein CD2763 1 None None None 126700474 Common - putative transporter CD2858 218 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 126697759 Common pyrD dihydroorotate dehydrogenase 1B CD0186 200 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 126699576 Pathogen - hypothetical protein CD1967 1 None None None 126698030 Common - AraC-family transcriptional regulator CD0454 127 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 126700433 Common - ABC transporter, ATP-binding/permease protein CD2817 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 126701052 Common cbiD cobalt-precorrin-6A synthase CD3429 90 COG1903 CbiD, Cobalamin biosynthesis protein CbiD Coenzyme metabolism 126698110 Common - DeoR-family transcriptional regulator CD0531 83 COG2378 COG2378, Predicted transcriptional regulator Transcription 126700213 Common - putative antibiotic resistance ABC transporter,ATP-binding protein CD2593 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 126698850 Common rpsP 30S ribosomal protein S16 CD1253 213 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 126699586 Common mutS DNA mismatch repair protein CD1977 206 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 126699725 Common - putative drug/sodium antiporter CD2108 180 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 126700642 Pathogen - hypothetical protein CD3024 1 None None None 126698826 Common sigK sporulation sigma factor SigK CD1230 216 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 126700480 Common - putative esterase/halogenase CD2864 139 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 126700457 Common - putative amidohydrolase CD2841 115 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 126699635 Common - AraC-family transcriptional regulator CD2018 142 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 126700171 Common tlpB transposase-like protein B CD2553a 73 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 126698746 Common minE cell division topological specificity factor CD1151 39 COG0851 MinE, Septum formation topological specificity factor Cell division and chromosome partitioning 126697941 Common - conjugative transposon protein CD0371 6 None None None 126699074 Common - putative phage shock protein CD1470 142 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 126700488 Common uxaA putative altronate hydrolase CD2872 73 COG2721 UxaA, Altronate dehydratase Carbohydrate transport and metabolism 126699429 Common tlpB transposase-like protein B CD1821 74 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 126698347 Common srlB PTS system, glucitol/sorbitol-specific IIa component CD0767 19 COG3731 SrlB, Phosphotransferase system sorbitol-specific component IIA Carbohydrate transport and metabolism 126698793 Common spoiIIIAF putative stage III sporulation protein AF CD1197 4 None None None 126699916 Common - hypothetical protein CD2300 2 None None None 126698633 Common - putative inorganic polyphosphate/ATP-NAD kinase CD1049 240 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 126700019 Common - putative DNA topoisomerase CD2404 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 126700947 Common - congative transposon conserved hypothetical protein CD3328 6 None None None 126698393 Common - putative PTS system, IIb component CD0813 4 COG1445 FrwB, Phosphotransferase system fructose-specific component IIB Carbohydrate transport and metabolism 126698412 Common aksA trans-homoaconitate synthase CD0832 193 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 126700106 Common - transcriptional antiterminator CD2489 42 COG3711 BglG, Transcriptional antiterminator Transcription 126701009 Pathogen - conjugative transposon protein CD3387A 5 None None None 126700103 Common - PTS system, IIc component CD2486 67 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 126699355 Common - hypothetical protein CD1748 8 None None None 126700072 Common - hypothetical protein CD2455 6 COG1583 COG1583, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 126698374 Common nadE NH3-dependent NAD(+) synthetase CD0794 219 COG0171 NadE, NAD synthase Coenzyme metabolism 126699108 Pathogen - putative ABC transporter, permease protein CD1505 1 None None None 126698284 Common - putative DNA repair protein CD0705 32 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 126698899 Pathogen - hypothetical protein CD1301A 1 None None None 126697637 Common fusA translation elongation factor G CD0070 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 126701297 Common - hypothetical protein CD3669 2 None None None 126698274 Common - putative exported peptidase CD0695 34 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 126700899 Common - putative transcription antiterminator CD3280 161 COG3933 COG3933, Transcriptional antiterminator Transcription 126700406 Pathogen - hypothetical protein CD2790 2 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 126699413 Common scrR putative sucrose operon repressor (LacI-family transcriptional regulator) CD1804 129 COG1609 PurR, Transcriptional regulators Transcription 126698586 Common - putative regulatory protein CD1002 103 COG2606 EbsC, Uncharacterized conserved protein Function unknown 126697664 Common infA translation initiation factor IF-1 CD0094 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 126700404 Common - putative cell wall teichoic acid glycosylation protein CD2788 18 COG2246 COG2246, Predicted membrane protein Function unknown 126700410 Common - surface surface protein CD2794 12 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 126697567 Common dnaA chromosomal replication initiator protein CD0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 126698817 Pathogen - hypothetical protein CD1221 1 None None None 126698698 Common - hypothetical protein CD1107 2 None None None 126700911 Pathogen - hypothetical protein CD3292 1 None None None 126701143 Pathogen - hypothetical protein CD3519 1 COG5245 DYN1, Dynein, heavy chain Cytoskeleton 126699642 Common - putative ABC transporter, permease protein CD2025 4 None None None 126698213 Common - hypothetical protein CD0635 76 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 126698419 Pathogen - putative membrane-associated CAAX amino terminal protease CD0839 1 None None None 126699583 Common hfQ HfQ protein CD1974 127 COG1923 Hfq, Uncharacterized host factor I protein General function prediction only 126699677 Common - putative lipid kinase CD2060 115 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 126699972 Common trxB3 thioredoxin reductase CD2356 246 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 126698164 Common - hypothetical protein CD0586 2 None None None 126698017 Common - hypothetical protein CD0443 7 None None None 126699337 Common - putative ATP-binding protein CD1730 229 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 126697935 Common - putative lantibiotic ABC transporter, permease protein CD0365 6 COG4200 COG4200, Uncharacterized protein conserved in bacteria Function unknown 126701034 Common uvrA excinuclease ABC subunit A CD3411 245 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 126700565 Pathogen - hypothetical protein CD2947 1 None None None 126698235 Common cdu2 putative Na(+)/H(+) antiporter CD0657 14 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 126699813 Common - putative subunit of oxidoreductase CD2197 71 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 126701117 Common - hypothetical protein CD3493 8 None None None 126701094 Common atpH ATP synthase subunit delta CD3471 184 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 126700730 Common - putative amidohydrolase CD3113 153 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 126698329 Common - putative ATP-dependent DNA helicase CD0749 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 126699756 Common tsf elongation factor Ts CD2139 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 126700985 Common - putative signaling protein CD3365 174 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126700540 Common - phage terminase large subunit CD2922 17 COG1783 XtmB, Phage terminase large subunit General function prediction only 126699241 Common - putative calcium-transporting ATPase CD1637 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 126700796 Common glnF RNA polymerase sigma-54 factor CD3176 145 COG1508 RpoN, DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog Transcription 126698478 Common opuCC glycine betaine/carnitine/choline ABC transporter, substrate-binding protein CD0901 179 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 126699347 Common grdG sarcosine reductase complex component B alpha subunit CD1740 8 None None None 126699525 Common eutL putative ethanolamine/propanediol utilization protein CD1915 15 COG4816 EutL, Ethanolamine utilization protein Amino acid transport and metabolism 126698770 Common ackA acetate kinase CD1175 162 COG0282 ackA, Acetate kinase Energy production and conversion 126699573 Common - hypothetical protein CD1964 7 COG1309 AcrR, Transcriptional regulator Transcription 126699613 Common - hypothetical protein CD2002 3 COG1813 COG1813, Predicted transcription factor, homolog of eukaryotic MBF1 Transcription 126698432 Common - MarR-family transcriptional regulator CD0852 66 COG1846 MarR, Transcriptional regulators Transcription 126697624 Common tufA elongation factor Tu CD0058 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 126698298 Common fhs formate--tetrahydrofolate ligase CD0718 89 COG2759 MIS1, Formyltetrahydrofolate synthetase Nucleotide transport and metabolism 126699622 Pathogen - conserved hypothetical plasmid protein CD2007A 1 None None None 126698444 Pathogen - hypothetical protein CD0867 1 None None None 126699386 Common - putative arsenate reductase CD1777 110 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 126698102 Common - two-component response regulator CD0521 208 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126700650 Common - putative aminotransferase CD3032 235 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 126700998 Common mgtC Magnesium transporting ATPase protein C CD3375 118 COG1285 SapB, Uncharacterized membrane protein Function unknown 126700836 Common snorO putative nogalamycin resistance protein CD3217 245 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 126700691 Common gatY tagatose-bisphosphate aldolase CD3074 176 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 126699849 Common asrB anaerobic sulfite reductase subunit B CD2232 117 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 126700149 Common - putative aminotransferase CD2532 151 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 126698753 Common - radical SAM-superfamily protein CD1158 63 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 126700584 Common - hypothetical protein CD2964 26 COG3382 COG3382, Uncharacterized conserved protein Function unknown 126699194 Common - hypothetical protein CD1590 30 COG1284 COG1284, Uncharacterized conserved protein Function unknown 126698991 Common - putative chloromuconate cycloisomerase CD1389 152 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 126700331 Common - hypothetical protein CD2716 4 None None None 126698074 Common orf21 conjugative transposon FtsK/SpoIIIE-family protein CD0498 89 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 126698892 Common scpA segregation and condensation protein A CD1295 101 COG1354 COG1354, Uncharacterized conserved protein Function unknown 126697652 Common rplE 50S ribosomal protein L5 CD0084 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 126697749 Common - putative oxidoreductase, NAD/FAD binding subunit CD0176 241 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 126699032 Pathogen - hypothetical protein CD1428A 1 None None None 126698810 Common spo0A stage 0 sporulation protein A CD1214 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126698067 Common - putative sugar-phosphate dehydrogenase CD0490 217 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 126701239 Common - hypothetical protein CD3613 1 None None None 126699803 Common - putative phage-related cell wall hydrolase CD2187 69 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 126701304 Common jag SpoIIIJ-associated protein CD3677 70 COG1847 Jag, Predicted RNA-binding protein General function prediction only 126699944 Common gatB PTS system, galactitol-specific IIb component CD2326 18 COG3414 SgaB, Phosphotransferase system, galactitol-specific IIB component Carbohydrate transport and metabolism 126700962 Pathogen - conjugative transposon conserved hypothetical protein CD3342A 6 None None None 126698220 Common - putative transcriptional regulator CD0642 40 COG1476 COG1476, Predicted transcriptional regulators Transcription 126700739 Common - putative flavodoxin CD3121 16 COG1145 NapF, Ferredoxin Energy production and conversion 126701271 Common - hypothetical protein CD3644 17 COG3589 COG3589, Uncharacterized conserved protein Function unknown 126700145 Common - hypothetical protein CD2528 3 None None None 126700441 Common - putative flavodoxin CD2825 7 COG0716 FldA, Flavodoxins Energy production and conversion 126697630 Common rplJ 50S ribosomal protein L10 CD0063 210 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 126697952 Common - conjugative transposon FtsK/SpoIIIE-related protein CD0383 42 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 126698617 Common mnaA UDP-N-acetylglucosamine 2-epimerase CD1033 151 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 126698496 Pathogen - hypothetical protein CD0919 1 None None None 126697917 Common - putative guanosine 3',5'-bis-pyrophosphate (ppGpp) synthesis/degradation protein CD0345 33 COG2357 COG2357, Uncharacterized protein conserved in bacteria Function unknown 126700755 Common - PTS system, IIabc component CD3137 60 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 126699650 Common argJ arginine biosynthesis bifunctional protein ArgJ CD2033 167 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 126698048 Common - putative iron-sulfur flavoprotein CD0472 35 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 126700844 Common asd aspartate-semialdehyde dehydrogenase CD3224 236 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 126700779 Pathogen - putative ABC transporter, permease protein CD3160 2 None None None 126699554 Common - putative glyoxalase CD1945 8 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 126700698 Common - PTS system, IIc component CD3081 37 COG1455 CelB, Phosphotransferase system cellobiose-specific component IIC Carbohydrate transport and metabolism 126700449 Common - putative transport-related ATPase CD2833 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 126698449 Common maa maltose O-acetyltransferase CD0872 124 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 126698185 Common tlpB' putative transposase-like protein B CD0607a 10 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 126700760 Common - hypothetical protein CD3143 26 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 126699695 Common - putative amidohydrolase CD2078 161 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 126699532 Common eutN putative ethanolamine/propanediol utilization protein CD1922 25 COG4576 CcmL, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 126698330 Common - amino acid ABC transporter, substrate-binding protein CD0750 177 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 126701045 Common cbiK sirohydrochlorin cobaltochelatase CD3422 128 COG4822 CbiK, Cobalamin biosynthesis protein CbiK, Co2+ chelatase Coenzyme metabolism 126699391 Common - two-component response regulator CD1782 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126698815 Common - hypothetical protein CD1219 12 None None None 126699766 Common - putative endonuclease/exonuclease/phosphatase CD2150 33 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 126699958 Common - hypothetical protein CD2340 1 None None None 126701195 Common - putative peptidase CD3569 11 None None None 126700553 Common - hypothetical protein CD2935 1 COG4728 COG4728, Uncharacterized protein conserved in bacteria Function unknown 126699139 Common sseA putative 3-mercaptopyruvate sulfurtransferase CD1535 142 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 126699702 Common dpaL1 diaminopropionate ammonia-lyase CD2085 158 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 126700163 Common - endoglucanase (cellulase) CD2546 29 COG2730 BglC, Endoglucanase Carbohydrate transport and metabolism 126698319 Pathogen - hypothetical protein CD0739 1 None None None 126700708 Common treA trehalose-6-phosphate hydrolase CD3091 160 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 126699034 Common - putative exported polysaccharide deacetylase CD1430 99 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 126700560 Pathogen - putative phage resolvase/integrase (partial) CD2942 1 None None None 126700969 Common bclA3 putative exosporium glycoprotein CD3349 5 None None None 126698595 Common glmD glucosamine-6-phosphate deaminase CD1011 81 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 126698086 Common tetM conjugative transposon tetracycline resistance protein CD0508 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 126698645 Common - hypothetical protein CD1061 8 None None None 126697683 Pathogen - hypothetical protein CD0111A 1 None None None 126697991 Common - putative cell surface protein CD0420 3 COG2433 COG2433, Uncharacterized conserved protein Function unknown 126697911 Common - two-component response regulator CD0339 219 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 126698530 Pathogen - hypothetical protein CD0949 1 None None None 126700198 Common stp serine/threonine phosphatase CD2579 128 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 126700743 Common - PTS system, IIabc component CD3125 60 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 126701172 Common - putative signal peptidase II CD3548 58 COG1774 COG1774, Uncharacterized homolog of PSP1 Function unknown 126700254 Common - putative ATP-binding protein CD2640 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 126700978 Common - AsnC-family transcriptional regulator CD3358 165 COG1522 Lrp, Transcriptional regulators Transcription 126699349 Common - two-component response regulator CD1743 109 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 126700421 Common ruvB Holliday junction DNA helicase B CD2805 240 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 126697595 Common - hypothetical protein CD0029 46 COG4956 COG4956, Integral membrane protein (PIN domain superfamily) General function prediction only 126698600 Common - MerR-family transcriptional regulator CD1016 58 COG0789 SoxR, Predicted transcriptional regulators Transcription 126698864 Common - putative ABC transporter, permease protein CD1267 5 None None None 126698901 Common - NAD-dependent deacetylase CD1303 152 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 126701151 Common - putative iron ABC transporter, ATP-binding protein CD3527 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 126698108 Common - hypothetical protein CD0529 20 None None None 126701258 Common - putative isochorismatase CD3632 68 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 126700551 Common - hypothetical protein CD2933 8 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 126700701 Common garK glycerate kinase CD3084 81 COG1929 COG1929, Glycerate kinase Carbohydrate transport and metabolism 126701221 Common - hypothetical protein CD3594 5 None None None 126699847 Common nirC putative nitrite transporter CD2230 98 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 126699541 Common - putative tyrosine recombinase CD1932 201 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 126697826 Common flgE flagellar hook protein CD0255 126 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 126699928 Common cspD cold shock protein CD2310 180 COG1278 CspC, Cold shock proteins Transcription 126700780 Common - putative ABC transporter, permease permease CD3161 3 None None None 126699375 Pathogen - putative lipoprotein CD1766 1 None None None 126697574 Pathogen - hypothetical protein CD0008 1 None None None 126698342 Common - putative transcription antiterminator CD0762 34 COG3711 BglG, Transcriptional antiterminator Transcription 126700243 Common spoIVA stage IV sporulation protein A CD2629 15 None None None 126699996 Common iorA indolepyruvate oxidoreductase subunit CD2381 116 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 126700521 Common - putative phage cell wall hydrolase CD2904 13 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 126699202 Common - putative endonuclease CD1598 68 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 126698268 Common - putative nucleotide phosphodiesterase CD0689 85 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 126699079 Common - putative hydrolase CD1475 21 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 126698023 Common - Na+/H+ antiporter CD0449 67 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 126699427 Common - hypothetical protein CD1819 9 None None None 126700725 Common - hypothetical protein CD3108 11 COG1284 COG1284, Uncharacterized conserved protein Function unknown 126697803 Common flgL flagellar hook-associated protein CD0232 83 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 126699906 Common - putative transcriptional regulator CD2291 56 COG1476 COG1476, Predicted transcriptional regulators Transcription 126698146 Common - hypothetical protein CD0567 54 COG1307 DegV, Uncharacterized protein conserved in bacteria Function unknown 126699130 Common pyrC dihydroorotase CD1526 213 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 126698703 Common - hypothetical protein CD1111 4 None None None 126699786 Common - putative cNMP-binding regulatory protein CD2170 80 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 126701027 Common cls putative cardiolipin synthetase CD3404 153 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 126701108 Common hemK protein methyltransferase CD3485 233 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 126701230 Common - putative exported phosphoesterase CD3603 102 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 126698312 Common - putative radical SAM superfamily protein CD0732 44 COG2516 COG2516, Biotin synthase-related enzyme General function prediction only 126699209 Common - hypothetical protein CD1605 9 COG4978 COG4978, Transcriptional regulator, effector-binding domain/component Transcription / Signal transduction mechanisms 126698410 Common - hypothetical protein CD0830 8 COG3949 COG3949, Uncharacterized membrane protein Function unknown 126697775 Common - putative signaling protein CD0204 163 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 126699533 Common - putative ethanolamine/propanediol utilization protein CD1923 16 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 126697853 Pathogen - hypothetical protein CD0281 1 None None None 126699179 Common - putative arylesterase CD1576 99 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 126698465 Common speA arginine decarboxylase CD0888 104 COG1982 LdcC, Arginine/lysine/ornithine decarboxylases Amino acid transport and metabolism 126699723 Common - putative ATP-dependent RNA helicase CD2106 238 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 126700942 Common - hypothetical protein CD3323 10 COG4332 COG4332, Uncharacterized protein conserved in bacteria Function unknown 126700017 Common - putative cell wall hydrolase CD2402 149 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 126698537 Common - phage protein CD0955 5 None None None 126701024 Common - putative phosphoesterase CD3401 90 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 126701257 Common - putative transcription antiterminator CD3631 45 COG3711 BglG, Transcriptional antiterminator Transcription 126698544 Common - putative phage cell wall hydrolase CD0960 13 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 126700260 Common ftsZ cell division protein CD2646 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 126701046 Common cbiJ cobalt-precorrin-6a reductase CD3423 75 COG2099 CobK, Precorrin-6x reductase Coenzyme metabolism 126699086 Common ssuC putative aliphatic sulfonate ABC transporter,permease protein CD1482 188 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 126700532 Common - phage protein CD2913 1 None None None 126699607 Common - AraC-family transcriptional regulator CD1996 109 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 126701112 Common gtaB utp--glucose-1-phosphate uridylyltransferase (general stress protein 33) CD3488 234 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 126701251 Common - putative signaling protein CD3625 182 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126700714 Common - PTS system, IIabc component CD3097 60 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 126700158 Common - sodium:dicarboxylate symporter family protein CD2541 157 COG1823 COG1823, Predicted Na+/dicarboxylate symporter General function prediction only 126700789 Pathogen secG putative subunit of preprotein translocase CD3169A 1 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 126698417 Common - putative reductase CD0837 42 COG0778 NfnB, Nitroreductase Energy production and conversion 126700346 Pathogen - hypothetical protein CD2731 1 None None None 126699854 Pathogen - hypothetical protein CD2237 1 None None None 126701084 Common - putative regulator of cell growth CD3461 62 COG2337 MazF, Growth inhibitor Signal transduction mechanisms 126699681 Pathogen - hypothetical protein CD2064 1 None None None 126700363 Common - putative transferase CD2748 215 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 126697649 Common rpsQ 30S ribosomal protein S17 CD0081 226 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 126698579 Common serA putative D-3-phosphoglycerate dehydrogenase CD0995 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 126699621 Common erm2(B) rRNA adenine N-6-methyltransferase (erythromycin resistance protein) CD2007 216 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 126700732 Common bglA2 6-phospho-beta-glucosidase BglA CD3115 102 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 126700268 Common mraY phospho-N-acetylmuramoyl-pentapeptide-transferas e CD2654 227 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 126700625 Common - 2-keto-3-deoxygluconate permease CD3004 27 COG2855 COG2855, Predicted membrane protein Function unknown 126698986 Common - GntR-family transcriptional regulator CD1383 15 COG0490 COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels Inorganic ion transport and metabolism 126697785 Common - hypothetical protein CD0214 2 None None None 126698602 Common - putative ABC transporter, permease/ATP-binding protein CD1018 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 126698249 Common - putative regulatory protein CD0670 11 COG3682 COG3682, Predicted transcriptional regulator Transcription 126697717 Common - putative RNA-binding protein CD0145 147 COG2183 Tex, Transcriptional accessory protein Transcription 126699667 Common rluB putative 23S RNA and tRNA pseudouridine synthase CD2050 205 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 126698304 Common - putative carbon monoxide dehydrogenase/acetyl-CoA synthase complex,nickel-inserting subunit CD0724 33 COG3640 CooC, CO dehydrogenase maturation factor Cell division and chromosome partitioning 126698121 Common - putative chemotaxis-related protein-glutamate methylesterase CD0542 151 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 126698264 Common infC translation initiation factor IF-3 CD0685 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 126700342 Common - hypothetical protein CD2727 45 COG2966 COG2966, Uncharacterized conserved protein Function unknown 126701278 Common - putative metallo-beta-lactamase superfamily protein CD3651 60 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 126699492 Common - hypothetical protein CD1880 5 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 126700044 Common - putative oxidoreductase subunit CD2429 111 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 126700858 Common - hypothetical protein CD3238 2 None None None 126697776 Common - putative transcription antiterminator CD0205 28 COG3711 BglG, Transcriptional antiterminator Transcription 126699734 Common trxB2 thioredoxin reductase CD2117 249 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 126700154 Common - putative membrane-associated 5'-nucleotidase/phosphoesterase CD2537 143 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 126700913 Common - putative type IV pilin CD3294 17 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 126698201 Common - putative phage-related regulatory protein CD0624 3 COG5566 COG5566, Uncharacterized conserved protein Function unknown 126700282 Common licT putative transcription antiterminator CD2668 29 COG3711 BglG, Transcriptional antiterminator Transcription 126699475 Common - putative conjugative transposon egulatory protein CD1864 8 COG3655 COG3655, Predicted transcriptional regulator Transcription 126700314 Common - putative sigma54-interacting regulatory protein CD2700 168 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 126697816 Common flgB flagellar basal-body rod protein CD0245 13 COG1815 FlgB, Flagellar basal body protein Cell motility and secretion 126698430 Common - hypothetical protein CD0850 87 COG0694 COG0694, Thioredoxin-like proteins and domains Posttranslational modification, protein turnover, chaperones 126699828 Common - ABC transporter, ATP-binding/permease protein CD2211 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 126700089 Common - hypothetical protein CD2472 6 COG3398 COG3398, Uncharacterized protein conserved in archaea Function unknown 126698621 Common - hypothetical protein CD1037 1 None None None 126698171 Common - hypothetical protein CD0593 1 None None None 126699861 Common - putative signaling protein CD2244 176 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126699873 Pathogen - hypothetical protein CD2255 1 None None None 126698519 Common - phage protein CD0940 7 None None None 126699251 Common - putative iron compound ABC transporter, permease protein CD1647 189 COG4606 CeuB, ABC-type enterochelin transport system, permease component Inorganic ion transport and metabolism 126699228 Common vanR two-component response regulator CD1624 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126698950 Common - putative lantibiotic ABC transporter, permease protein CD1351 4 COG4200 COG4200, Uncharacterized protein conserved in bacteria Function unknown 126700637 Common - putative sugar uptake protein CD3017 11 COG4975 GlcU, Putative glucose uptake permease Carbohydrate transport and metabolism 126700604 Common - hypothetical protein CD2983 56 COG2378 COG2378, Predicted transcriptional regulator Transcription 126700872 Common folC putative folylpolyglutamate synthase CD3253 217 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 126699215 Common - hypothetical protein CD1611 5 None None None 126701064 Common - putative aminotransferas CD3441 228 COG1168 MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities Amino acid transport and metabolism 126699123 Common - putative acetyltransferase CD1519 80 COG2153 ElaA, Predicted acyltransferase General function prediction only 126701166 Common spmA spore maturation protein A CD3542 39 COG2715 SpmA, Uncharacterized membrane protein, required for spore maturation in B.subtilis. General function prediction only 126698137 Common glsA glutaminase CD0558 72 COG2066 GlsA, Glutaminase Amino acid transport and metabolism 126700036 Common - putative peptidase CD2421 164 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 126697894 Common - hypothetical protein CD0322 44 COG0714 COG0714, MoxR-like ATPases General function prediction only 126698823 Common - putative O-methyltransferase CD1227 115 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 126697698 Common spoIIID stage III sporulation protein D CD0126 15 None None None 126700696 Common ascB 6-phospho-beta-glucosidase CD3079 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 126698191 Common - ABC transporter, ATP-binding protein CD0613 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126700812 Common - putative phage-related protein CD3193 7 None None None 126698510 Common - hypothetical protein CD0932 1 None None None 126700464 Common - hypothetical protein CD2848 4 None None None 126700753 Common - hypothetical protein CD3135 176 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 126701186 Common - putative ATPase CD3560 224 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 126700926 Common - putative phosphoesterase CD3307 52 COG0622 COG0622, Predicted phosphoesterase General function prediction only 126699437 Common kdpD two-component sensor histidine kinase CD1829 223 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 126699150 Common - putative hemolysin-like membrane protein CD1546 102 COG1272 COG1272, Predicted membrane protein, hemolysin III homolog General function prediction only 126699516 Pathogen - hypothetical protein CD1906 1 None None None 126697691 Common - phosphoglucomutase/phosphomannomutase mutase CD0119 242 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 126698919 Common - putative peptidase CD1320 201 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 126701011 Common - putative conjugative transposon FtsK_SpoIIIE-related protein CD3389 38 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 126699025 Common - putative signaling protein CD1420 175 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126698158 Common gapN NADP-dependent glyceraldehyde-3-phosphate dehydrogenase CD0580 223 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 126699719 Common - putative Na(+)/H(+) antiporter CD2102 134 COG3263 COG3263, NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain Inorganic ion transport and metabolism 126700227 Common - probable peptidase CD2613 248 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 126699963 Common - LysR-family regulatory protein CD2345 153 COG0583 LysR, Transcriptional regulator Transcription 126699489 Common vncS two-component system, sensor histidine kinase CD1877 154 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126699268 Common guaD guanine deaminase CD1663 152 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 126699741 Common - putative transporter CD2124 142 COG0679 COG0679, Predicted permeases General function prediction only 126698915 Common rpsO 30S ribosomal protein S15 CD1316 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 126698848 Common - hypothetical protein CD1251A 26 COG2739 COG2739, Uncharacterized protein conserved in bacteria Function unknown 126697610 Pathogen - hypothetical protein CD0044 1 None None None 126699258 Common lplA putative lipoate-protein ligase CD1654 87 COG0095 LplA, Lipoate-protein ligase A Coenzyme metabolism 126699261 Common - putative bi-functional glycine dehydrogenase/aminomethyl transferase protein CD1657 179 COG0403 GcvP, Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain Amino acid transport and metabolism 126698960 Common - putative phage regulatory protein CD1360A 32 COG1476 COG1476, Predicted transcriptional regulators Transcription 126700323 Common - putative NADH-dependent flavin oxidoreductase CD2709 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 126697886 Common - hypothetical protein CD0314 105 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 126698876 Common iscS2 cysteine desulfurase CD1279 240 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 126698159 Common - TetR-family transcriptional regulator CD0581 101 COG1309 AcrR, Transcriptional regulator Transcription 126699699 Common - probable amidohydrolase CD2082 179 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 126697981 Common - putative conjugal transfer protein CD0412 74 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 126698969 Common - putative phage cell wall hydrolase CD1368 144 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 126699234 Common - putative membrane-associated metal-dependent hydrolase CD1630 32 COG1988 COG1988, Predicted membrane-bound metal-dependent hydrolases General function prediction only 126697832 Common fliP flagellar biosynthesis protein FliP CD0260 128 COG1338 FliP, Flagellar biosynthesis pathway, component FliP Cell motility and secretion / Intracellular trafficking and secretion 126698353 Common spoVAC stage V sporulation protein AC CD0773 15 None None None 126701228 Common - D-alanyl-D-alanine carboxypeptidase CD3601 39 COG1876 VanY, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 126699884 Common - PTS system, IIbc component CD2269 143 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 126698662 Common - hypothetical protein CD1075 35 COG0434 SgcQ, Predicted TIM-barrel enzyme General function prediction only 126700826 Common - putative Na+ driven multidrug efflux pump CD3207 135 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 126699909 Pathogen - hypothetical protein CD2294 1 None None None 126700239 Common - hypothetical protein CD2625 8 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 126698234 Common - putative chloride ion channel protein CD0656 159 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 126698302 Common - putative methylenetetrahydrofolate reductase CD0722 56 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 126699933 Pathogen - hypothetical protein CD2315 1 None None None 126701162 Common phnG putative phosphonate metabolism protein CD3538 11 COG3624 PhnG, Uncharacterized enzyme of phosphonate metabolism Inorganic ion transport and metabolism 126699682 Common - putative regulatory protein CD2065 17 COG3682 COG3682, Predicted transcriptional regulator Transcription 126698711 Pathogen - putative lipoprotein CD1119 2 None None None 126700058 Common spoIV putative stage IV sporulation protein CD2442 15 None None None 126699148 Pathogen - hypothetical protein CD1543A 1 None None None 126698665 Common - PTS system, IId component CD1078 41 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 126699856 Common - putative sodium:solute symporter CD2239 162 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 126698831 Pathogen - hypothetical protein CD1234 1 None None None 126698723 Common coaE putative dephospho-CoA kinase CD1129 197 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 126697619 Common - hypothetical protein CD0053 38 COG1939 COG1939, Uncharacterized protein conserved in bacteria Function unknown 126699388 Common - hypothetical protein CD1779 74 COG1606 COG1606, ATP-utilizing enzymes of the PP-loop superfamily General function prediction only 126699446 Common aroE shikimate dehydrogenase CD1837 224 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 126697703 Common - hypothetical protein CD0131 20 COG3949 COG3949, Uncharacterized membrane protein Function unknown 126697792 Common purG phosphoribosylformylglycinamidine cyclo-ligase CD0221 233 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 126700537 Pathogen - hypothetical protein CD2919 1 None None None 126697987 Common - hypothetical protein CD0417 4 None None None 126701158 Common phnK phosphonate ABC transporter, ATP-binding protein CD3534 249 COG4107 PhnK, ABC-type phosphonate transport system, ATPase component Inorganic ion transport and metabolism 126697693 Common - putative thiosulfate sulfurtransferase CD0121 111 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 126697871 Common rbsK putative ribokinase CD0299 187 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 126700218 Common - putative oligosaccharide deacetylase CD2598 124 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 126698730 Common - hypothetical protein CD1136 3 None None None 126698400 Common - two-component response regulator CD0820 220 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126699063 Common - putative 5-nitroimidazole reductase CD1459 29 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 126701129 Common - putative type IV pilus retraction protein (putative twitching mobility protein) CD3505 209 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 126699302 Common - putative sodium:amino acid symporter CD1696 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 126700049 Common glyQ glycyl-tRNA synthetase subunit alpha CD2433 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 126701157 Common phnL phosphonate ABC transporter, ATP-binding protein CD3533 249 COG4778 PhnL, ABC-type phosphonate transport system, ATPase component Inorganic ion transport and metabolism 126697671 Common - ABC transporter, ATP-binding protein CD0100 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 126701016 Common - putative RNA methyltransferase CD3393 198 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 126701199 Pathogen - hypothetical protein CD3572 1 None None None 126699448 Common tyrC putative prephenate dehydrogenase CD1839 140 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 126700621 Common - putative dihydrodipicolinate synthase CD3000 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 126701182 Common - hypothetical protein CD3556 12 COG4684 COG4684, Predicted membrane protein Function unknown 126699874 Common - putative PTS system, EIIc component CD2256 17 COG3641 PfoR, Predicted membrane protein, putative toxin regulator General function prediction only 126700652 Common - putative sugar-specific transcriptional regulator CD3034 28 COG1378 COG1378, Predicted transcriptional regulators Transcription 126700523 Pathogen - phage protein CD2906 1 None None None 126699975 Common - putative hydrolase CD2359 142 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 126699169 Common ilvB putative acetolactate synthase large subunit CD1566 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 126698998 Common - putative amino acid amidase CD1396 35 COG2362 DppA, D-aminopeptidase Amino acid transport and metabolism 126700038 Common - probable transporter CD2423 49 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 126698096 Common - D-alanyl-D-alanine carboxypeptidase CD0515 156 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 126700032 Common srlE PTS system, glucitol/sorbitol-specific IIbc component CD2417 22 COG3732 SrlE, Phosphotransferase system sorbitol-specific component IIBC Carbohydrate transport and metabolism 126699159 Common - putative amino acid permease CD1555 183 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 126699278 Common - hypothetical protein CD1673 9 None None None 126698737 Pathogen - hypothetical protein CD1142A 1 None None None 126699729 Pathogen - hypothetical protein CD2112 1 None None None 126698156 Common - putative efflux protein CD0578 82 None None None 126698751 Common - hypothetical protein CD1156 1 COG5279 CYK3, Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain Cell division and chromosome partitioning 126700016 Common cotJC2 putative spore-coat protein CD2401 44 COG3546 COG3546, Mn-containing catalase Inorganic ion transport and metabolism 126699895 Common - PTS system, IIc component CD2280 19 COG3775 GatC, Phosphotransferase system, galactitol-specific IIC component Carbohydrate transport and metabolism 126698929 Common - hypothetical protein CD1330 16 COG3972 COG3972, Superfamily I DNA and RNA helicases General function prediction only 126697706 Common - putative transcription antiterminator CD0134 33 COG3711 BglG, Transcriptional antiterminator Transcription 126700024 Common - hypothetical protein CD2409 2 None None None 126700330 Pathogen - hypothetical protein CD2715A 1 None None None 126697989 Common - hypothetical protein CD0419 4 None None None 126698942 Common glnA glutamine synthetase CD1343 221 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 126699961 Common cat1 succinyl-CoA:coenzyme A transferase CD2343 95 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 126698651 Common ccpA LacI-family transcriptional regulator (catabolite control protein) CD1064 129 COG1609 PurR, Transcriptional regulators Transcription 126698916 Common - hypothetical protein CD1317 53 COG1307 DegV, Uncharacterized protein conserved in bacteria Function unknown 126699556 Common - ABC transporter, ATP-binding protein CD1947 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126697928 Pathogen - conjugative transposon conserved hypothetical protein CD0358 4 None None None 126699317 Common - hypothetical protein CD1710 15 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 126699088 Common ssuA putative aliphatic sulfonates ABC transporter,substrate-binding lipoprotein CD1484 103 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 126698344 Common gutA PTS system, glucitol/sorbitol-specific IIc2 component CD0764 22 COG3730 SrlA, Phosphotransferase system sorbitol-specific component IIC Carbohydrate transport and metabolism 126698912 Common truB tRNA pseudouridine synthase B CD1314 245 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 126699785 Common - iron-sulfur binding protein CD2169 36 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 126699883 Common - putative oxidoreductase CD2266 118 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 126700435 Common - putative amino acid racemase CD2819 68 COG3616 COG3616, Predicted amino acid aldolase or racemase Amino acid transport and metabolism 126700646 Common - putative phosphosugar isomerase CD3028 158 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 126698830 Pathogen - hypothetical protein CD1233A 1 None None None 126699791 Common - probable amino-acid ABC transporter, permease protein CD2175 178 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 126699730 Common - two-component sensor histidine kinase CD2113 218 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 126697694 Common - hypothetical protein CD0122 5 None None None 126697974 Common - putative RNA pseudouridine synthase CD0405 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 126697854 Common - putative hydrolase CD0282 35 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 126698646 Common acpP acyl carrier protein CD1062 209 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 126699459 Common - AraC-family transcriptional regulator CD1850 94 COG3708 COG3708, Uncharacterized protein conserved in bacteria Function unknown 126697600 Common - putative xylose transporter CD0034 79 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 126699450 Common - putative signaling protein CD1841 194 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126699307 Common recQ ATP-dependent DNA helicase CD1701 233 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 126698467 Common speE spermidine synthase CD0890 125 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 126701089 Common acpS 4'-phosphopantetheinyl transferase CD3466 161 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 126699033 Common - hypothetical protein CD1429 7 COG3393 COG3393, Predicted acetyltransferase General function prediction only 126699436 Common ftsH1 cell division protein CD1828 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 126699230 Common vanG putative D-alanine:D-alanine ligase (putative vancomycin/teicoplanin A-type resistance protein) CD1626 214 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 126699265 Common tlpA transposase-like protein A CD1660A 2 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 126697578 Common - putative small-molecule-binding protein CD0012 16 COG1827 COG1827, Predicted small molecule binding protein (contains 3H domain) General function prediction only 126697892 Common - two-component response regulator CD0320 226 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126698773 Common fapR fatty acid biosynthesis transcriptional regulator CD1177 18 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 126697844 Common - hypothetical protein CD0272 1 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 126700348 Common - putative aminotransferase CD2733 233 COG1168 MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities Amino acid transport and metabolism 126699542 Common - hypothetical protein CD1933 6 None None None 126699217 Pathogen - hypothetical protein CD1613 1 None None None 126700921 Common chrA chromate transport protein CD3302 115 COG2059 ChrA, Chromate transport protein ChrA Inorganic ion transport and metabolism 126698952 Common - putative pyridoxine kinase CD1353 87 COG2240 PdxK, Pyridoxal/pyridoxine/pyridoxamine kinase Coenzyme metabolism 126700638 Common - hypothetical protein CD3018 15 None None None 126701100 Common - putative cytidine and deoxycytidylate deaminase CD3477 97 COG2131 ComEB, Deoxycytidylate deaminase Nucleotide transport and metabolism 126701060 Common cobS cobalamin synthase CD3437 151 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 126700514 Pathogen - hypotheticalphage protein CD2897 1 COG5281 COG5281, Phage-related minor tail protein Function unknown 126699855 Common - hypothetical protein CD2238 33 COG2731 EbgC, Beta-galactosidase, beta subunit Carbohydrate transport and metabolism 126700468 Common dltB D-alanyl transferase CD2852 85 COG1696 DltB, Predicted membrane protein involved in D-alanine export Cell envelope biogenesis, outer membrane 126701138 Common prs ribose-phosphate pyrophosphokinase CD3514 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 126700382 Common - putative penicillin-binding protein repressor CD2766 62 COG1316 LytR, Transcriptional regulator Transcription 126698527 Pathogen - hypothetical protein CD0946A 1 None None None 126697963 Common ldhA (R)-2-hydroxyisocaproate dehydrogenase CD0394 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 126698140 Common - putative aldo/keto reductase CD0561 166 COG1453 COG1453, Predicted oxidoreductases of the aldo/keto reductase family General function prediction only 126699652 Common - hypothetical protein CD2035 39 COG0628 PerM, Predicted permease General function prediction only 126698601 Common - putative ABC transporter, permease/ATP-binding protein CD1017 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 126699549 Pathogen - hypothetical protein CD1940 1 None None None 126700315 Common - putative lipoprotein CD2701 6 None None None 126697979 Common - hypothetical protein CD0410 65 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 126700867 Common - probable polysaccharide deacetylase CD3248 125 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 126701189 Common - putative spore cortex-lytic enzyme CD3563 33 COG3773 SleB, Cell wall hydrolyses involved in spore germination Cell envelope biogenesis, outer membrane 126700429 Common garR tartronate semialdehyde reductase CD2813 197 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 126697984 Common - putativel membrane protein CD0414 3 None None None 126698509 Pathogen - hypothetical protein CD0931 1 None None None 126698837 Pathogen - putative phage-related DNA-directed RNA polymerase 7 kDa polypeptide CD1240A 1 None None None 126697612 Common - putative lipoate-protein ligase CD0046 65 COG0095 LplA, Lipoate-protein ligase A Coenzyme metabolism 126699761 Common - hypothetical protein CD2144 14 COG1971 COG1971, Predicted membrane protein Function unknown 126698303 Common - putative carbon monoxide dehydrogenase/acetyl-CoA synthase complex, dihydrolipoyl dehydrogenase subunit CD0723 242 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 126700619 Common - putative iron ABC transporter, permease protein CD2998 192 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 126698177 Common - transcriptional regulator (partial) CD0599 9 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 126699237 Common - putative serine protease CD1633 220 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 126699735 Common thrC threonine synthase CD2118 132 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 126699363 Common - putative transcriptional regulator CD1755A 61 COG1476 COG1476, Predicted transcriptional regulators Transcription 126698827 Common - site-specific recombinase CD1231 75 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 126697777 Common - PTS system, IIa component CD0206 117 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 126699069 Common - two-component sensor kinase CD1465 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126700757 Common - putative transcriptional regulator CD3139 61 COG1476 COG1476, Predicted transcriptional regulators Transcription 126698373 Common - hypothetical protein CD0793 22 COG0730 COG0730, Predicted permeases General function prediction only 126698513 Pathogen - phage protein CD0934A 1 None None None 126700000 Common - putative signaling protein CD2385 174 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126699256 Common - putative tellurium resistance protein CD1652 20 COG4110 COG4110, Uncharacterized protein involved in stress response General function prediction only 126700458 Common - nitrilase (carbon-nitrogen hydrolase) CD2842 140 COG0388 COG0388, Predicted amidohydrolase General function prediction only 126701192 Common ipk 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase CD3566 197 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 126700324 Common - hypothetical protein CD2710 21 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 126698546 Common - phage protein CD0962 2 None None None 126697817 Common flgC flagellar basal-body rod protein CD0246 126 COG1558 FlgC, Flagellar basal body rod protein Cell motility and secretion 126698395 Common - probable transporter CD0815 41 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 126698616 Common - hypothetical protein CD1032 7 None None None 126698144 Common nth endonuclease III CD0565 240 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 126698855 Common - putative GTPase CD1258 153 COG1161 COG1161, Predicted GTPases General function prediction only 126698427 Common - hypothetical protein CD0847 2 None None None 126698366 Common - hypothetical protein CD0786 7 COG4478 COG4478, Predicted membrane protein Function unknown 126700683 Common xylR xylose repressor CD3066 120 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 126697861 Common - PTS system, IId component CD0289 40 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 126699866 Common - hypothetical protein CD2248 58 COG3825 COG3825, Uncharacterized protein conserved in bacteria Function unknown 126700230 Pathogen - hypothetical protein CD2616 1 COG4531 ZnuA, ABC-type Zn2+ transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 126697997 Common - putative mobilization protein CD0426 5 None None None 126698696 Common - DNA topoisomerase CD1106 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 126698382 Common - putative CoA-transferase CD0802 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 126698937 Common glvG maltose-6'-phosphate glucosidase CD1338 53 COG1486 CelF, Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases Carbohydrate transport and metabolism 126698866 Common - two-component response regulator CD1269 218 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 126699477 Common - putative conjugative transposon conserved hypothetical protein CD1866 13 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 126698585 Common - ABC transporter, ATP-binding protein CD1001 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 126698631 Common - cell surface protein CD1047 9 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126700007 Common - hypothetical protein CD2392 38 COG3382 COG3382, Uncharacterized conserved protein Function unknown 126699371 Common - hypothetical protein CD1762 9 None None None 126700476 Common - hypothetical protein CD2860 7 None None None 126697990 Pathogen - hypothetical protein CD0419A 1 None None None 126698666 Common - LysR-family transcriptional regulator CD1079 191 COG0583 LysR, Transcriptional regulator Transcription 126701255 Common - ascorbate-specific PTS system enzyme IIC CD3629 36 COG3037 SgaT, Uncharacterized protein conserved in bacteria Function unknown 126698204 Pathogen - putative phage positive regulator of late transcription CD0627 1 COG5566 COG5566, Uncharacterized conserved protein Function unknown 126698118 Common cheA chemotaxis protein CD0539 165 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 126700726 Common - putative pentose-5-phosphate 3-epimerase CD3109 205 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 126698708 Common - hypothetical protein CD1116 5 None None None 126698266 Common rplT 50S ribosomal protein L20 CD0687 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 126698104 Common - putative transcriptional regulator CD0523 7 None None None 126699295 Common - two-component sensor histidine kinase CD1689 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126698139 Common nfo endonuclease IV CD0560 107 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 126698301 Common - hypothetical protein CD0721 18 None None None 126700533 Pathogen - hypothetical protein CD2914 1 None None None 126699609 Common - TetR-family transcriptional regulator CD1998 101 COG1309 AcrR, Transcriptional regulator Transcription 126698010 Pathogen - hypothetical protein CD0437A 1 None None None 126700267 Common murD UDP-N-acetylmuramoylalanine--D-glutamate ligase CD2653 208 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 126700184 Common - putative transcriptional antiterminator CD2565 34 COG3711 BglG, Transcriptional antiterminator Transcription 126700367 Common - hypothetical protein CD2751 6 None None None 126700877 Common - iron-only hydrogenase CD3258 28 COG4624 COG4624, Iron only hydrogenase large subunit, C-terminal domain General function prediction only 126697599 Common - putative beta-xylosidase CD0033 39 COG3507 XynB, Beta-xylosidase Carbohydrate transport and metabolism 126699170 Common - putative manganese-containing catalase CD1567 47 COG3546 COG3546, Mn-containing catalase Inorganic ion transport and metabolism 126698145 Common - putative RNA methylase CD0566 156 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 126701160 Common phnI putative phosphonate metabolism protein CD3536 45 COG3626 PhnI, Uncharacterized enzyme of phosphonate metabolism Inorganic ion transport and metabolism 126700833 Common - AraC-family transcriptional regulator CD3214 118 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 126700206 Common coaBC coenzyme A biosynthesis bifunctional protein CD2587 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 126697722 Common - putative glycoprotease CD0150 192 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 126701233 Common - ferredoxin CD3605A 33 COG1141 Fer, Ferredoxin Energy production and conversion 126697910 Common - two-component sensor histidine kinase CD0338 54 COG3290 CitA, Signal transduction histidine kinase regulating citrate/malate metabolism Signal transduction mechanisms 126697827 Common - putative flagellar protein CD0255A 25 COG1582 FlgEa, Uncharacterized protein, possibly involved in motility Cell motility and secretion 126697587 Common pyc pyruvate carboxylase CD0021 240 COG1038 PycA, Pyruvate carboxylase Energy production and conversion 126700010 Common - hypothetical protein CD2395 25 COG4642 COG4642, Uncharacterized protein conserved in bacteria Function unknown 126697915 Common - hypothetical protein CD0343 2 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 126699953 Common guaB inositol-5-monophosphate dehydrogenase CD2335 233 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 126701105 Common - hypothetical protein CD3482 240 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 126698847 Common ftsY putative signal recognition particle CD1251 246 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 126697787 Common - transposase CD0216 55 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 126700675 Common - PTS system, IIa component CD3058 59 COG2190 NagE, Phosphotransferase system IIA components Carbohydrate transport and metabolism 126698166 Pathogen - hypothetical protein CD0588 1 None None None 126698028 Pathogen - hypothetical protein CD0453A 1 None None None 126700716 Common - putative amidohydrolase CD3099 166 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 126701065 Common - putative peptidase CD3442 239 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 126700842 Common sdaB L-serine dehydratase CD3222 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 126698701 Common - modification DNA methylase CD1109 99 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 126700809 Common - MerR-family transcriptional regulator CD3190 128 COG0789 SoxR, Predicted transcriptional regulators Transcription 126701075 Common - GntR-family transcriptional regulator CD3452 127 COG2188 PhnF, Transcriptional regulators Transcription 126700578 Common ntpE V-type sodium ATP synthase subunit E CD2958 19 COG1390 NtpE, Archaeal/vacuolar-type H+-ATPase subunit E Energy production and conversion 126699077 Common - ABC transporter, ATP-binding/permease protein CD1473 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 126700721 Common - putative hydrolase CD3104 146 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 126700273 Common lgt prolipoprotein diacylglyceryl transferase CD2659 200 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 126697647 Common rplP 50S ribosomal protein L16 CD0080 220 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 126700424 Common - hypothetical protein CD2808 3 None None None 126700955 Pathogen - conjugative tyransposon conserved hypothetical protein CD3335 6 None None None 126698196 Common - putative transcriptional regulator CD0618 12 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 126699281 Common pcp pyrrolidone-carboxylate peptidase CD1676 54 COG2039 Pcp, Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase) Posttranslational modification, protein turnover, chaperones 126698243 Common - hypothetical protein CD0664B 3 None None None 126701004 Common - conjugative transposon protein CD3383 17 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 126699683 Common - integrase CD2066 148 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 126698327 Common - putative lipoprotein CD0747 16 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 126700817 Common cme multidrug resistance protein CD3198 113 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 126698134 Common sip2 singal peptidase I CD0555 169 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 126698533 Common - phage protein CD0952 2 None None None 126699857 Common nanA N-acetylneuraminate lyase CD2240 234 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 126697687 Common - ferredoxin CD0115 66 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 126699663 Pathogen - hypothetical protein CD2046 1 None None None 126700703 Common hrsA 2-O-a-mannosyl-D-glycerate specific PTS transporten components IIABC CD3086 107 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 126700904 Common pgi glucose-6-phosphate isomerase CD3285 202 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 126700928 Common dnaL DNA ligase CD3309 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 126699914 Pathogen - hypothetical protein CD2298 1 None None None 126697770 Common - putative membrane-associated nucleotidase CD0199 86 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 126698863 Common - putative ABC transporter, permease protein CD1266 2 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 126699203 Common thiD putative phosphomethylpyrimidine kinase CD1599 222 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 126700785 Common - putative transcriptional regulator CD3166 124 COG1733 COG1733, Predicted transcriptional regulators Transcription 126700902 Common pflE putative pyruvate formate-lyase 3 activating enzyme CD3283 69 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 126699271 Common - putative glycerophosphoryl diester phosphodiesterase CD1666 155 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 126699840 Pathogen - putative conjugative transposon protein CD2223 6 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 126699090 Pathogen - putative lipoprotein CD1486 1 None None None 126700940 Common - hypothetical protein CD3321 7 None None None 126699640 Common - GntR-family transcriptional regulator CD2023 129 COG1725 COG1725, Predicted transcriptional regulators Transcription 126700081 Common hemN oxygen-independent coproporphyrinogen III oxidase CD2464 209 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 126698420 Common - putative hydrolase CD0840 177 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 126699340 Common - putative methyltransferase CD1733 12 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 126699405 Common - putative nitrite and sulfite reductase subunit CD1796 136 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 126698840 Pathogen - hypothetical protein CD1244 1 None None None 126698761 Common hom1 homoserine dehydrogenase CD1166 217 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 126698084 Pathogen orf13 putative conjugative transposon exported protein CD0507 6 None None None 126698707 Common - putative conjugal transfer protein CD1115 68 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 126701113 Common - putative oligopeptidase CD3489 84 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 126698684 Common - two-component sensor histidine kinase CD1098 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126698518 Pathogen - hypothetical protein CD0939 1 None None None 126698963 Common - hypothetical protein CD1363 6 None None None 126698334 Common thiI putative thiamine biosynthesis protein CD0754 98 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 126699114 Common - hypothetical protein CD1510 21 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 126698596 Pathogen - hypothetical protein CD1012 1 None None None 126700136 Common - integrase CD2519 49 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 126699817 Common - putative histidinol-phosphate aminotransferase CD2200 242 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 126701224 Common - hypothetical protein CD3597 13 None None None 126698655 Common - putative polysaccharide biosynthesis/sporulation protein CD1068 38 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 126701150 Common - putative iron ABC transporter, permease protein CD3526 204 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 126700055 Common - putative membrane-associated kinase and phosphatase CD2439 79 COG0818 DgkA, Diacylglycerol kinase Cell envelope biogenesis, outer membrane 126697625 Common rpmG 50S ribosomal protein L33 CD0058A 48 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 126699136 Common - ABC transporter, ATP-binding protein CD1532 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126699615 Common effD putative efflux pump CD2003 166 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 126699425 Common - putative acyltransferase CD1817 58 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 126700693 Common tagK putative tagatose (1)-phosphate-kinase CD3076 102 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 126699806 Common - cyclomaltodextrinase (maltogenic alpha-amylase) CD2190 163 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 126698875 Common - RRF2-family transcriptional regulator CD1278 167 COG1959 COG1959, Predicted transcriptional regulator Transcription 126699685 Common - ABC transporter, ATP-binding protein CD2068 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 126700589 Common dpaA dipicolinate synthase subunit A CD2968 13 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 126699692 Common pbuX xanthine permease CD2075 124 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 126697788 Common - putative nitroreductase CD0217 100 COG0778 NfnB, Nitroreductase Energy production and conversion 126701119 Common - putative RNA-binding protein CD3495 46 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 126699526 Common - putative ethanolamine/propanediol utilisation protein CD1916 48 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 126700148 Common - hypothetical protein CD2531 15 COG4720 COG4720, Predicted membrane protein Function unknown 126697954 Common - conjugative transposon protein CD0385 6 None None None 126699351 Pathogen - hypothetical protein CD1745 1 None None None 126700736 Common - putative glycosyltransferase CD3119 43 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 126700799 Common - putative dihydroorotate dehydrogenase, catalytic subunit CD3179 150 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 126699407 Common - LysR-family transcriptional regulator CD1798 192 COG0583 LysR, Transcriptional regulator Transcription 126698245 Common cdd3 putative lantibiotic ABC transporter, peremase protein CD0666 7 COG4200 COG4200, Uncharacterized protein conserved in bacteria Function unknown 126698239 Pathogen tcdE putative cell wall hydrolase protein CD0661 1 COG4824 COG4824, Phage-related holin (Lysis protein) General function prediction only 126700795 Common cggR central glycolytic genes regulator CD3175 44 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 126698775 Common fabH 3-oxoacyl-[acyl-carrier-protein] synthase III CD1179 223 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 126700598 Common - hypothetical protein CD2977 34 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 126699941 Common - putative carbohydrate dehydrogenase CD2323 211 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 126701007 Pathogen - conjugative transposon protein CD3386 5 None None None 126698499 Pathogen - hypothetical protein CD0922 1 None None None 126700093 Common - hypothetical protein CD2476 28 COG4552 Eis, Predicted acetyltransferase involved in intracellular survival and related acetyltransferases General function prediction only 126698014 Pathogen - regulatory protein (partial) CD0440A 1 None None None 126698337 Common - putative signaling protein CD0757 180 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 126699468 Common - putative cell surface protein CD1858 3 COG2433 COG2433, Uncharacterized conserved protein Function unknown 126699342 Common - putative hydrolase CD1735 95 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 126697939 Pathogen - hypothetical protein CD0369 1 None None None 126698441 Common - 6-phospho-alpha-glucosidase CD0864 53 COG1486 CelF, Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases Carbohydrate transport and metabolism 126698439 Common - PTS system, IIc component CD0862 38 COG1455 CelB, Phosphotransferase system cellobiose-specific component IIC Carbohydrate transport and metabolism 126700849 Common dapB2 dihydrodipicolinate reductase CD3229 217 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 126699412 Common - cell surface protein CD1803 5 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126701090 Common atpC ATP synthase epsilon chain (partial) CD3467 79 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 126698729 Common - putative cell wall hydrolase CD1135 138 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 126698299 Common fchA methenyltetrahydrofolate cyclohydrolase CD0719 37 COG3404 COG3404, Methenyl tetrahydrofolate cyclohydrolase Amino acid transport and metabolism 126698956 Common - putative peptidyl-prolyl isomerase CD1357 162 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 126701298 Common - putative selenocysteine lyase CD3670 243 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 126699539 Common - hypothetical protein CD1930 125 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 126698811 Common - putative pyrophosphokinase CD1215 21 COG4825 COG4825, Uncharacterized membrane-anchored protein conserved in bacteria Function unknown 126698475 Common - hypothetical protein CD0898 7 COG4868 COG4868, Uncharacterized protein conserved in bacteria Function unknown 126698044 Common malL oligo-1,6-glucosidase CD0468 164 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 126698079 Pathogen orf17 conjugative transposon membrane protein CD0501 6 None None None 126700448 Common - putative cation efflux protein CD2832 219 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 126698226 Common - GntR-family transcriptional regulator CD0648 101 COG1802 GntR, Transcriptional regulators Transcription 126700896 Common - PTS system, IIc component CD3277 40 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 126699023 Pathogen - hypothetical protein CD1418B 1 None None None 126698682 Common - putative lantibiotic ABC transporter, permease protein CD1096 2 COG4200 COG4200, Uncharacterized protein conserved in bacteria Function unknown 126699530 Common - putative propanediol/ethanolamine utilization protein CD1920 36 COG4869 PduL, Propanediol utilization protein Secondary metabolites biosynthesis, transport, and catabolism 126699443 Common aroA 3-phosphoshikimate 1-carboxyvinyltransferase CD1834 234 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 126698184 Common - chloride ion channel protein CD0606 168 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 126697658 Common rpmD 50S ribosomal protein L30 CD0088A 91 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 126700787 Common - hypothetical protein CD3168 29 None None None 126700178 Common recG ATP-dependent DNA helicase CD2560 221 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 126697701 Common - hypothetical protein CD0129 14 None None None 126699819 Common - putative sodium/solute symporter CD2202 105 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 126701284 Common dnaB replicative DNA helicase CD3657 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 126700165 Common - putative sugar transporter, permease protein CD2548 167 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 126698494 Common - putative phage recombination protein CD0917 10 None None None 126701208 Common - hypothetical protein CD3581 119 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 126698255 Common - hypothetical protein CD0676 1 None None None 126698995 Common - hypothetical protein CD1393 60 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 126700571 Common - phage site-specific recombinase CD2952 126 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 126701277 Common - putative signaling protein CD3650 169 COG1455 CelB, Phosphotransferase system cellobiose-specific component IIC Carbohydrate transport and metabolism 126698801 Common ispA geranyltranstransferase CD1205 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 126698215 Common - putative acetyltransferase CD0637 21 COG0456 RimI, Acetyltransferases General function prediction only 126699335 Common - putative sodium/phosphate cotransporter CD1729 97 COG1283 NptA, Na+/phosphate symporter Inorganic ion transport and metabolism 126699197 Common kdpC potassium-transporting ATPase C chain CD1593 95 COG2156 KdpC, K+-transporting ATPase, c chain Inorganic ion transport and metabolism 126699798 Common - hypothetical protein CD2182 2 None None None 126699584 Common miaA tRNA delta(2)-isopentenylpyrophosphate transferase CD1975 214 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 126700996 Pathogen - hypothetical protein CD3374 1 None None None 126698629 Common - hypothetical protein CD1045 57 COG0628 PerM, Predicted permease General function prediction only 126700748 Common acsB3 putative 6-phospho-beta-glucosidase CD3130 101 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 126699381 Common - hypothetical protein CD1772 2 None None None 126698888 Common dacF D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein) CD1291 155 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 126697667 Common rpsK 30S ribosomal protein S11 CD0096 247 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 126699593 Common - hypothetical protein CD1985 2 None None None 126700759 Pathogen - hypothetical protein CD3141 1 None None None 126700160 Common - putative polysaccharide O-acetylase CD2543 85 COG1696 DltB, Predicted membrane protein involved in D-alanine export Cell envelope biogenesis, outer membrane 126698232 Pathogen - putative ABC transporter, permease protein CD0654 2 None None None 126699321 Common moaC molybdenum cofactor biosynthesis protein C CD1714 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 126698385 Common - electron transfer flavoprotein alpha-subunit CD0805 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 126698056 Common spaE putative lantibiotic ABC transporter, permease protein CD0479 5 COG4200 COG4200, Uncharacterized protein conserved in bacteria Function unknown 126701268 Common - hypothetical protein CD3641 15 None None None 126699346 Common - two-component response regulator CD1739 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 126698749 Common - PadR-family transcriptional regulator CD1154 65 COG1695 COG1695, Predicted transcriptional regulators Transcription 126699581 Common - hypothetical protein CD1972 196 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 126700481 Common - putative bacterioferritin CD2865 9 COG3546 COG3546, Mn-containing catalase Inorganic ion transport and metabolism 126699632 Common - hypothetical protein CD2015 13 COG4767 VanZ, Glycopeptide antibiotics resistance protein Defense mechanisms 126700489 Common - putative signaling protein CD2873 164 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 126700914 Common - putative type IV pilus-assembly protein CD3295 145 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 126700835 Common - putative osmoprotectant ABC transporter,substrate-binding/permease protein CD3216 163 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 126700293 Common bdhA D-beta-hydroxybutyrate dehydrogenase CD2679 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 126699190 Pathogen - hypothetical protein CD1586 1 None None None 126699263 Common - probable cation-transporting ATPase CD1659 232 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 126697634 Common rpoC DNA-directed RNA polymerase subunit beta' CD0067 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 126701037 Common - ABC transporter, solute-binding protein CD3414 118 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 126700111 Common fdhA selenocysteine synthase CD2495 75 COG1921 SelA, Selenocysteine synthase [seryl-tRNASer selenium transferase] Amino acid transport and metabolism 126699015 Common - sigma-54 dependent regulatory protein CD1412 174 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 126700516 Common - phage protein CD2899 4 COG4385 gpI, Bacteriophage P2-related tail formation protein General function prediction only 126699334 Common - hypothetical protein CD1728 2 None None None 126697708 Common - PTS system, IIb component CD0136 30 COG1440 CelA, Phosphotransferase system cellobiose-specific component IIB Carbohydrate transport and metabolism 126700567 Common - putative phage anti-repressor CD2948 11 None None None 126699119 Common - putative signaling protein CD1515 175 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 126699801 Common - hypothetical protein CD2185 2 None None None 126698286 Common - putative signaling protein CD0707 188 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126700247 Common - hypothetical protein CD2633 32 COG1625 COG1625, Fe-S oxidoreductase, related to NifB/MoaA family Energy production and conversion 126700074 Common - hypothetical protein CD2457 21 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 126700100 Common - hypothetical protein CD2483 132 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 126699985 Common nadC nicotinate-nucleotide pyrophosphorylase (carboxylating) CD2370 204 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 126699654 Common - putative acetyltransferase CD2037 7 None None None 126699579 Common - putative cyclase CD1970 113 COG1878 COG1878, Predicted metal-dependent hydrolase General function prediction only 126700677 Common glvA putative maltose-6'-phosphate glucosidase CD3060 54 COG1486 CelF, Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases Carbohydrate transport and metabolism 126700392 Common - putative glycosyl transferase CD2776 62 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 126700105 Common - pts system, IIa component CD2488 38 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 126700497 Common - hypothetical protein CD2881 42 COG3394 COG3394, Uncharacterized protein conserved in bacteria Function unknown 126699853 Common - putative glucokinase CD2236 110 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 126699889 Pathogen - hypothetical protein CD2274 1 None None None 126697949 Pathogen - conjugative transposon protein CD0380 1 None None None 126699998 Common - putative sigma-54 interacting regulatory protein CD2383 168 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 126700399 Common - putative glycosyltransferase CD2783 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 126700376 Common - putative signaling protein CD2760 164 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 126698603 Common - hypothetical protein CD1019 11 None None None 126699778 Common - putative acetyltransferase CD2162 8 COG0456 RimI, Acetyltransferases General function prediction only 126698796 Common - hypothetical protein CD1200 39 COG1302 COG1302, Uncharacterized protein conserved in bacteria Function unknown 126699482 Common - hypothetical protein CD1871 18 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 126697961 Common - Radical SAM-superfamily protein CD0392 19 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 126700369 Common - putative signaling protein CD2753 161 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 126701238 Common - putative glyoxalase CD3610 15 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 126697968 Common acdB acyl-CoA dehydrogenase, short-chain specific CD0399 166 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 126698988 Common - probable transporter CD1385 36 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 126697953 Common - conjugative transposon protein CD0384 6 None None None 126697733 Common - hypothetical protein CD0163 1 None None None 126698618 Common - putative mannosyl-glycoprotein endo-beta-N-acetylglucosamidase CD1034 70 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 126698001 Common - hypothetical protein CD0430 21 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 126700462 Common - hypothetical protein CD2846 3 None None None 126700731 Common - hypothetical protein CD3114 7 None None None 126699612 Pathogen - hypothetical protein CD2001 3 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126700222 Common - two-component sensor histidine kinase CD2602 105 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 126700214 Common uraA uracil permease CD2594 123 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 126701048 Common cbiG cobalamin biosynthesis protein CbiG CD3425 91 COG2073 CbiG, Cobalamin biosynthesis protein CbiG Coenzyme metabolism 126700930 Pathogen - hypothetical protein CD3311 1 None None None 126699753 Pathogen - hypothetical protein CD2136A 1 None None None 126698759 Common obg Spo0B-associated GTP-binding protein CD1164 249 COG0536 Obg, Predicted GTPase General function prediction only 126699396 Common - MerR-family transcriptional regulator CD1787 51 COG0789 SoxR, Predicted transcriptional regulators Transcription 126700774 Common - phage integrase CD3156 56 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 126698210 Pathogen - hypothetical protein CD0632 1 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 126700803 Common - peptidase CD3183 212 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 126698525 Common - phage portal protein CD0945 11 None None None 126700355 Common hisS putative histidyl-tRNA synthetase CD2740 245 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126699246 Common - hypothetical protein CD1642 24 None None None 126699727 Common fsaB fructose-6-phosphate aldolase 2 CD2110 144 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 126698554 Common - hypothetical protein CD0970 2 None None None 126700121 Common - TetR-family transcriptional regulator CD2505 21 COG1309 AcrR, Transcriptional regulator Transcription 126700333 Common - putative sortase B CD2718 5 COG4509 COG4509, Uncharacterized protein conserved in bacteria Function unknown 126701082 Common tkt' transketolase, pyridine binding subunit CD3459 231 COG3958 COG3958, Transketolase, C-terminal subunit Carbohydrate transport and metabolism 126698112 Common cheB chemotaxis protein CD0533 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 126701261 Pathogen - hypothetical protein CD3635 1 None None None 126697839 Pathogen - hypothetical protein CD0267 1 None None None 126699328 Pathogen - putative transcriptional regulator CD1722 1 None None None 126698981 Pathogen - hypothetical protein CD1378B 1 None None None 126699044 Common - hypothetical protein CD1440 84 COG1346 LrgB, Putative effector of murein hydrolase Cell envelope biogenesis, outer membrane 126699181 Common - putative membrane-associated ribonuclease CD1578 79 COG1295 Rbn, Predicted membrane protein Function unknown 126699055 Common folB dihydroneopterin aldolase CD1451 68 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 126697868 Pathogen - hypothetical protein CD0296 1 None None None 126700066 Common - hypothetical protein CD2449 186 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 126699678 Common - hypothetical protein CD2061 21 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 126697812 Common - phosphoserine phosphatase CD0241 84 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 126699495 Pathogen - hypothetical protein CD1884 1 None None None 126697640 Common rplC 50S ribosomal protein L3 CD0073 249 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 126700883 Common - hypothetical protein CD3264 2 None None None 126698279 Common pheT phenylalanyl-tRNA synthetase subunit beta CD0700 249 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 126698689 Common - putative mobilization protein CD1102 10 None None None 126699188 Common - putative sugar metabolism repressor CD1584 93 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 126697754 Common - putative membrane-associated metalloprotease CD0181 17 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 126697899 Common cbiO cobalt ABC transporter, ATP-binding protein CD0327 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 126699970 Common grdE glycine reductase complex component B alpha and beta subunits CD2354 8 None None None 126698091 Common orf8 conjugative transposon protein CD0510A 6 None None None 126700668 Pathogen - hypothetical protein CD3050 2 None None None 126701301 Common - putative stage 0 sporulation protein CD3673 188 COG1475 Spo0J, Predicted transcriptional regulators Transcription 126698317 Common hisK histidinol-phosphatase CD0737 20 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 126700414 Common - cell surface protein CD2798 5 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126698541 Pathogen - putative phage lipoprotein CD0957 1 None None None 126698740 Common mreB2 rod shape-determining protein CD1145 236 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 126698976 Pathogen - putative phage-related protein CD1375 1 None None None 126698278 Common pheS phenylalanyl-tRNA synthetase alpha chain CD0699 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 126698717 Pathogen - hypothetical protein CD1124A 1 None None None 126697602 Common acoA acetoin:2,6-dichlorophenolindophenol oxidoreductase alpha subunit CD0036 154 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 126697820 Common fliG flagellar motor switch protein CD0249 123 COG1536 FliG, Flagellar motor switch protein Cell motility and secretion 126698175 Common cotJB1 putative spore-coat protein CD0597 9 None None None 126700823 Common - hypothetical protein CD3204 142 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 126698254 Common - putative acetyltransferase CD0675 46 COG0456 RimI, Acetyltransferases General function prediction only 126699006 Common - putative oligopeptide transporter CD1404 39 COG1297 COG1297, Predicted membrane protein Function unknown 126697766 Common groES 10 kDa chaperonin CD0193 211 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 126699186 Common - hypothetical protein CD1583 85 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 126697830 Common fliL flagellar basal body-associated protein CD0258 13 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 126697743 Common - redox-sensing transcriptional repressor Rex CD0171 56 COG2344 COG2344, AT-rich DNA-binding protein General function prediction only 126698332 Common - amino acid ABC transporter, ATP-binding protein CD0752 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 126698413 Common - aconitate hydratase CD0833 223 COG1048 AcnA, Aconitase A Energy production and conversion 126699145 Common - putative drug/sodium antiporter CD1541 166 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 126698766 Common etfB3 electron transfer flavoprotein beta-subunit CD1171 152 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 126698653 Pathogen - hypothetical protein CD1066 1 COG5593 COG5593, Nucleic-acid-binding protein possibly involved in ribosomal biogenesis Translation, ribosomal structure and biogenesis 126697676 Common rpsI 30S ribosomal protein S9 CD0105 247 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 126698409 Common - metallo-beta-lactamase superfamily protein CD0829 56 COG1237 COG1237, Metal-dependent hydrolases of the beta-lactamase superfamily II General function prediction only 126700963 Common - putative conjugative transposon replication initiation factor CD3343 8 COG2946 COG2946, Putative phage replication protein RstA DNA replication, recombination, and repair 126698360 Common - hypothetical protein CD0780 14 None None None 126700644 Common - hypothetical protein CD3026 10 COG3860 COG3860, Uncharacterized protein conserved in bacteria Function unknown 126697799 Common fliN flagellar motor switch protein CD0228 95 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 126699551 Common - tRNA guanine-N(7)-methyltransferase CD1942 164 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 126701215 Common carB carbamoyl phosphate synthase large subunit CD3588 237 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 126697781 Common - putative hydrolase CD0210 100 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 126697940 Common - putative transcriptional regulator CD0370 66 COG1476 COG1476, Predicted transcriptional regulators Transcription 126700496 Common celC PTS system, lichenan-specific IIa component CD2880 32 COG1447 CelC, Phosphotransferase system cellobiose-specific component IIA Carbohydrate transport and metabolism 126701203 Common - probable transporter CD3576 93 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 126699955 Common - hypothetical protein CD2337 2 COG4915 XpaC, 5-bromo-4-chloroindolyl phosphate hydrolysis protein General function prediction only 126698321 Common glpK1 glycerol kinase CD0741 179 COG0554 GlpK, Glycerol kinase Energy production and conversion 126698909 Common rbfA ribosome-binding factor A CD1310 192 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 126701071 Common gatY tagatose-bisphosphate aldolase CD3448 177 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 126697660 Common prlA preprotein translocase SecY subunit CD0090 239 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 126700507 Common - hypothetical protein CD2891 2 COG1952 SecB, Preprotein translocase subunit SecB Intracellular trafficking and secretion 126698675 Common - hypothetical protein CD1088 2 None None None 126697926 Pathogen xis excisionase CD0356 2 None None None 126699567 Common - putative reductive dehalogenase CD1958 31 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 126698296 Common cooS putative bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase CD0716 32 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 126698367 Common - putative metal-binding protein CD0787 10 COG2158 COG2158, Uncharacterized protein containing a Zn-finger-like domain General function prediction only 126700666 Common - PTS system, IIc component CD3048 38 COG1455 CelB, Phosphotransferase system cellobiose-specific component IIC Carbohydrate transport and metabolism 126701291 Common rpsF 30S ribosomal protein S6 CD3663 198 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 126698391 Common - putative signaling protein CD0811 166 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 126699210 Common - GntR-family transcriptional regulator CD1606 53 COG1725 COG1725, Predicted transcriptional regulators Transcription 126698310 Common - putative iron-sulfur protein CD0730 83 COG3894 COG3894, Uncharacterized metal-binding protein General function prediction only 126700544 Common - hypothetical protein CD2926 7 None None None 126698070 Common - PTS system, IIc component CD0493 36 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 126700256 Common sigG sporulation sigma factor SigG CD2642 216 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 126699518 Common pduU putative ethanolamine/propanediol utilization protein CD1908 20 COG4810 EutS, Ethanolamine utilization protein Amino acid transport and metabolism 126698290 Common argS arginyl-tRNA synthetase CD0711 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126697933 Common - putative lantibiotic ABC transporter, membrane protein CD0363 16 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 126698576 Common leuB 3-isopropylmalate dehydrogenase CD0992 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 126697685 Common buk butyrate kinase CD0113 131 COG3426 COG3426, Butyrate kinase Energy production and conversion 126700614 Common - hypothetical protein CD2993 23 COG4832 COG4832, Uncharacterized conserved protein Function unknown 126697576 Common rsbW anti-sigma-B factor (serine-protein kinase) CD0010 40 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 126700562 Common - putative phage essential recombination function protein CD2944 3 None None None 126699463 Pathogen - putative conjugative transposon membrane exported protein CD1854 1 None None None 126700500 Common licB PTS system, lichenan-specific IIb component CD2884 30 COG1440 CelA, Phosphotransferase system cellobiose-specific component IIB Carbohydrate transport and metabolism 126697800 Common flgM negative regulator of flagellin synthesis (anti-sigma-d factor) CD0229 2 COG2747 FlgM, Negative regulator of flagellin synthesis (anti-sigma28 factor) Transcription / Cell motility and secretion / Intracellular trafficking and secretion 126699225 Common - putative mechanosensitive ion channel protein CD1621 200 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 126697842 Common fliM putative flagellar motor switch protein CD0270 47 COG1868 FliM, Flagellar motor switch protein Cell motility and secretion 126697888 Common - putative ABC transporter, permease protein CD0316 3 COG4200 COG4200, Uncharacterized protein conserved in bacteria Function unknown 126698380 Common crt1 3-hydroxybutyryl-CoA dehydratase (crotonase) CD0800 188 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 126698457 Common - hypothetical protein CD0880 32 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 126699160 Common - putative polysaccharide deacetylase CD1556 84 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 126699220 Common - putative signaling protein CD1616 172 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 126701080 Common - hypothetical protein CD3457 2 None None None 126701245 Common - putative acetyltransferase CD3619 46 COG0456 RimI, Acetyltransferases General function prediction only 126700052 Common - putative Mg2+ transporter CD2436 187 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 126698168 Common - hypothetical protein CD0590 12 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 126699479 Common - conjugative transposon conserved hypothetical protein CD1868 3 None None None 126698021 Common - putative component of D-ornithine aminomutase CD0447 21 COG1649 COG1649, Uncharacterized protein conserved in bacteria Function unknown 126699267 Common - hypothetical protein CD1662 5 None None None 126699205 Common thiE1 thiamine-phosphate pyrophosphorylase CD1601 207 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 126698422 Common - hypothetical protein CD0842 7 None None None 126698854 Common rplS 50S ribosomal protein L19 CD1257 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 126700326 Common - hypothetical protein CD2712 6 None None None 126700869 Common - hypothetical protein CD3250 4 None None None 126699470 Common - putative conjugative transposon regulatory protein CD1859A 2 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 126699774 Common gabT 4-aminobutyrate aminotransferase CD2158 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 126698756 Common rplU 50S ribosomal protein L21 CD1161 209 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 126701067 Common - PTS system, IIb component CD3444 29 COG1440 CelA, Phosphotransferase system cellobiose-specific component IIB Carbohydrate transport and metabolism 126697678 Common aspC aspartate aminotransferase CD0107 239 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 126699745 Common ispG 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase CD2128 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 126701197 Pathogen - hypothetical protein CD3570A 1 None None None 126700959 Pathogen - conjugative transposon membrane protein CD3339 6 None None None 126701180 Common dusB tRNA-dihydrouridine synthase CD3554 221 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 126699722 Common - ABC transporter, ATP-binding protein CD2105 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126699749 Pathogen - hypothetical protein CD2133 4 None None None 126699365 Common - hypothetical protein CD1757 6 None None None 126697890 Common - ABC transporter, ATP-binding protein CD0318 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126697856 Common - PTS system, IIa component CD0284 68 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 126697863 Common - putative peptidase CD0291 121 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 126698288 Common - putative DNA mismatch repair protein CD0709 201 COG1193 COG1193, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 126698669 Common mobB molybdopterin-guanine dinucleotide biosynthesis protein B CD1082 112 COG1763 MobB, Molybdopterin-guanine dinucleotide biosynthesis protein Coenzyme metabolism 126700999 Common - putative transcriptional regulator CD3376 201 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126699219 Common - putative sodium extrusion ABC transporter,permease protein CD1615 37 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 126699070 Common - ABC transporter, ATP-binding protein CD1466 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126700937 Common fdhF formate dehydrogenase H CD3317 200 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 126698558 Pathogen - hypothetical protein CD0974 1 None None None 126698486 Pathogen - hypothetical protein CD0909 1 None None None 126698873 Common - recombination factor protein RarA CD1276 244 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 126699703 Common - putative iron-sulfur flavoprotein CD2086 44 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 126699232 Common vanTG serine/alanine racemase CD1628 202 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 126699239 Common - tellurium resistance protein CD1635 29 COG2310 TerZ, Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 Signal transduction mechanisms 126699869 Pathogen - hypothetical protein CD2251 1 None None None 126698429 Common abgB2 putative aminobenzoyl-glutamate utilization protein CD0849 127 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 126700029 Common srlB PTS system, IIa component CD2414 20 COG3731 SrlB, Phosphotransferase system sorbitol-specific component IIA Carbohydrate transport and metabolism 126700192 Common - probable hydrolase CD2573 25 COG0546 Gph, Predicted phosphatases General function prediction only 126700182 Common - conserved hypothetical protein (partial) CD2563 11 None None None 126699152 Common hisG putative ATP phosphoribosyltransferase CD1548 211 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 126698515 Common - putative phage endonuclease CD0936 17 COG4570 Rus, Holliday junction resolvase DNA replication, recombination, and repair 126697797 Common - putative transglycosylase CD0226 171 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 126699310 Common thiF putative thiamine biosynthesis protein CD1703 223 COG1179 COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Coenzyme metabolism 126700860 Common - hypothetical protein CD3240 6 None None None 126698735 Common rnfA electron transport complex protein CD1141 76 COG4657 RnfA, Predicted NADH:ubiquinone oxidoreductase, subunit RnfA Energy production and conversion 126700001 Common - hypothetical protein CD2386 1 None None None 126699254 Common - putative iron compound ABC transporter,substrate-binding protein CD1650 84 COG4607 CeuA, ABC-type enterochelin transport system, periplasmic component Inorganic ion transport and metabolism 126697846 Common dhaT putative 1,3-propanediol dehydrogenase CD0274 175 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 126700063 Common rpsU 30S ribosomal protein S21 CD2446a 101 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 126700623 Common - probable carbohydrate hydrolase CD3002 73 COG2721 UxaA, Altronate dehydratase Carbohydrate transport and metabolism 126699536 Common - AraC-family transcriptional regulator (partial) CD1926 106 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 126699938 Common rpiB1 ribose-5-phosphate isomerase 1 CD2320 128 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 126698142 Common - putative iron-sulfur cluster protein CD0563 134 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 126700596 Common - hypothetical protein CD2975 23 COG1343 COG1343, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 126698965 Common - hypothetical protein CD1365 1 None None None 126698996 Common - putative oxidoreductase CD1394 144 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 126699062 Common wrbA putative flavoprotein CD1458 100 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 126699871 Common - GntR-family transcriptioanl regulator CD2253 177 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 126697805 Common csrA carbon storage regulator CD0234 82 COG1551 CsrA, Carbon storage regulator (could also regulate swarming and quorum sensing) Signal transduction mechanisms 126700525 Pathogen - hypothetical protein CD2907A 1 None None None 126697571 Common gyrB DNA gyrase subunit B CD0005 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 126701031 Common - putative DNA mismatch repair protein CD3408 194 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 126701190 Common spoIIR stage II sporulation protein CD3564 15 None None None 126698153 Common - hypothetical protein CD0575 20 None None None 126700688 Common - glycosyl hydrolase CD3071 82 COG1501 COG1501, Alpha-glucosidases, family 31 of glycosyl hydrolases Carbohydrate transport and metabolism 126700022 Common - putative multidrug efflux pump, membrane protein CD2407 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 126698039 Common - TetR-family transcriptional regulator CD0463 61 COG1309 AcrR, Transcriptional regulator Transcription 126697627 Common nusG transcription antitermination protein CD0060 215 COG0250 NusG, Transcription antiterminator Transcription 126700609 Common - two-component system esponse regulator CD2988 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126697620 Common thyX FAD-dependent thymidylate synthase CD0054 58 COG1351 THY1, Predicted alternative thymidylate synthase Nucleotide transport and metabolism 126700654 Common - proton-dependent oligopeptide transporter CD3036 78 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 126699951 Common mtlR putative transcription antiterminator CD2333 35 COG3711 BglG, Transcriptional antiterminator Transcription 126698358 Common - hypothetical protein CD0778 21 None None None 126700141 Common nadD nicotinate-nucleotide adenylyltransferase CD2524 150 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 126699155 Common hisH putative imidazole glycerol phosphate synthase subunit CD1551 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 126698613 Common - putative cell wall anchored protein CD1029 11 COG5298 COG5298, Uncharacterized protein conserved in bacteria Function unknown 126701184 Common birA BirA bifunctional protein [includes: biotin operon repressor and biotin--[acetyl-CoA-carboxylase] synthetase CD3558 224 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 126701109 Common - hypothetical protein CD3486 31 COG3872 COG3872, Predicted metal-dependent enzyme General function prediction only 126698469 Common cspA cold shock protein CD0892 181 COG1278 CspC, Cold shock proteins Transcription 126699783 Common - patatin-like phospholipase CD2167 35 COG3621 COG3621, Patatin General function prediction only 126697614 Common ispF 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase CD0048 189 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 126700695 Common - hypothetical protein CD3078 2 COG2364 COG2364, Predicted membrane protein Function unknown 126699125 Common tyrR tyrosyl-tRNA synthetase CD1521 243 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126698910 Common - putative RNA-binding protein CD1311 83 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 126701087 Common - putative lipoprotein CD3464 4 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 126699419 Pathogen - putative two-component sensor histidine kinase (partial) CD1811 1 None None None 126699452 Common - hypothetical protein CD1843 9 COG5015 COG5015, Uncharacterized conserved protein Function unknown 126699881 Common - hypothetical protein CD2264 2 None None None 126698644 Common - putative pseudouridylate synthase CD1060 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 126698841 Pathogen - hypothetical protein CD1245 1 None None None 126698944 Common - PadR-family transcriptional regulator CD1345 63 COG1695 COG1695, Predicted transcriptional regulators Transcription 126699035 Common - putative exonuclease CD1431 137 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 126699315 Common - hypothetical protein CD1708 14 COG2357 COG2357, Uncharacterized protein conserved in bacteria Function unknown 126700179 Common - putative phosphatase CD2561 50 COG1461 COG1461, Predicted kinase related to dihydroxyacetone kinase General function prediction only 126697696 Common spoIIC stage II sporulation protein D CD0124 46 COG2385 SpoIID, Sporulation protein and related proteins Cell division and chromosome partitioning 126697972 Common fba putative fructose-bisphosphate aldolase CD0403 176 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 126700503 Common - putative signaling protein CD2887 133 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126701130 Pathogen - hypothetical protein CD3506 1 None None None 126697881 Common - putative phosphoserine phosphatase CD0309 43 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 126699434 Common metA homoserine O-succinyltransferase CD1826 64 COG1897 MetA, Homoserine trans-succinylase Amino acid transport and metabolism 126701020 Common - hypothetical protein CD3397 54 COG1481 COG1481, Uncharacterized protein conserved in bacteria Function unknown 126699509 Common - putative phage-related deoxycytidylate deaminase (putative late competence protein) CD1899 92 COG2131 ComEB, Deoxycytidylate deaminase Nucleotide transport and metabolism 126697995 Pathogen - putative single-strand binding protein CD0424 2 None None None 126697680 Common nrdG anaerobic ribonucleoside-triphosphate reductase activating protein CD0109 74 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 126699075 Common - putative membrane protein (putative phage infection protein) CD1471 36 COG1511 COG1511, Predicted membrane protein Function unknown 126700420 Common queA S-adenosylmethionine:tRNA ribosyltransferase-isomerase CD2804 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 126697590 Common - putative DNA repair protein CD0024 20 COG3880 COG3880, Uncharacterized protein with conserved CXXC pairs Function unknown 126697821 Common fliH flagellar assembly protein CD0250 16 COG1317 FliH, Flagellar biosynthesis/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 126700681 Common xylA xylose isomerase CD3064 68 COG2115 XylA, Xylose isomerase Carbohydrate transport and metabolism 126701029 Common hymB putative iron-only hydrogenase,electron-transferring subunit CD3406 182 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 126700053 Common era GTP-binding protein CD2437 239 COG1159 Era, GTPase General function prediction only 126700319 Common - putative amidohydrolas CD2705 174 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 126698535 Common - hypothetical protein CD0953A 1 None None None 126697729 Common - putative glyoxalase CD0159 8 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 126701115 Common - putative exopolyphosphatase CD3491 178 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 126700906 Common - hypothetical protein CD3287 81 COG2509 COG2509, Uncharacterized FAD-dependent dehydrogenases General function prediction only 126698194 Common - MerR-family transcriptional regulator CD0616 56 COG0789 SoxR, Predicted transcriptional regulators Transcription 126698281 Common - hypothetical protein CD0702 14 COG3619 COG3619, Predicted membrane protein Function unknown 126700127 Common - transcriptional antiterminator CD2511 29 COG3711 BglG, Transcriptional antiterminator Transcription 126700769 Pathogen - hypothetical protein CD3152 1 None None None 126699491 Pathogen - hypothetical protein CD1878b 2 None None None 126698224 Common - putative lantibiotic ABC transporter, permease protein CD0646 2 None None None 126699212 Common - putative ABC transporter, permease protein CD1608 3 None None None 126699670 Common lysA diaminopimelate decarboxylase CD2053 218 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 126700900 Common proC2 pyrroline-5-carboxylate reductase CD3281 216 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 126700953 Common - hypothetical protein CD3333A 2 None None None 126699901 Common - hypothetical protein CD2286 95 COG1296 AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) Amino acid transport and metabolism 126698325 Common - putative chemotaxis protein CD0745 159 COG1360 MotB, Flagellar motor protein Cell motility and secretion 126700425 Common - hypothetical protein CD2809 2 None None None 126700783 Common rnr ribonuclease R CD3164 193 COG0557 VacB, Exoribonuclease R Transcription 126700095 Common - metallo beta-lactamase superfamily lipoprotein CD2478 122 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 126699481 Common - putative conjugative transposon mobilization protein CD1870 5 None None None 126698389 Common - hypothetical protein CD0809 7 None None None 126699842 Pathogen - integrase (partial) CD2225 2 None None None 126700829 Common - hypothetical protein CD3210 8 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 126699537 Common - hypothetical protein CD1928 18 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 126698346 Common srlE' PTS system, glucitol/sorbitol-specific IIc component CD0766 22 COG3732 SrlE, Phosphotransferase system sorbitol-specific component IIBC Carbohydrate transport and metabolism 126698784 Common - putative glutamine amidotransferase CD1188 142 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 126698093 Common tndX conjugative transposon site-specific recombinase CD0511 84 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 126697897 Common cbiN cobalt transport protein CD0325 41 COG1930 CbiN, ABC-type cobalt transport system, periplasmic component Inorganic ion transport and metabolism 126699283 Common - hypothetical protein CD1678 28 COG3819 COG3819, Predicted membrane protein Function unknown 126698954 Common cspB putative cold shock protein CD1355 181 COG1278 CspC, Cold shock proteins Transcription 126700087 Common gpr germination protease CD2470 15 None None None 126698305 Common - acetyl-CoA decarbonylase/synthase complex subunit delta CD0725 20 COG2069 CdhD, CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein) Energy production and conversion 126701146 Common - hypothetical protein CD3522 2 COG4547 CobT, Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) Coenzyme metabolism 126700705 Common - putative cellobiose-phosphate degrading protein CD3088 25 COG3394 COG3394, Uncharacterized protein conserved in bacteria Function unknown 126700304 Common - putative membrane-associated phosphatase CD2690 95 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 126700014 Pathogen - hypothetical protein CD2399 1 None None None 126700558 Pathogen - hypothetical protein CD2940 1 None None None 126700793 Common pgk phosphoglycerate kinase CD3173 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 126698098 Common - hypothetical protein CD0517 54 COG2966 COG2966, Uncharacterized conserved protein Function unknown 126700389 Common - putative beta-glycosyltransferase CD2773 148 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 126698316 Common - hypothetical protein CD0736 4 COG4531 ZnuA, ABC-type Zn2+ transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 126698835 Common - putative regulatory protein CD1239 15 COG3682 COG3682, Predicted transcriptional regulator Transcription 126701002 Common - conjugative transposon protein CD3379 6 None None None 126699067 Pathogen - hypothetical protein CD1463 1 None None None 126699081 Common - putative ferrous iron transport protein CD1477 6 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 126700746 Common pgmB beta-phosphoglucomutase CD3128 156 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 126699827 Common - ABC transporter, ATP-binding/permease protein CD2210 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 126700965 Common - conjugative transposon conserved hypothetical protein CD3345 6 None None None 126699983 Common - hypothetical protein CD2368 3 None None None 126698905 Common nusA transcription elongation protein CD1307 225 COG0195 NusA, Transcription elongation factor Transcription 126698206 Common - hypothetical protein CD0628 10 None None None 126697779 Common - PTS system, IIb component CD0208 68 COG1445 FrwB, Phosphotransferase system fructose-specific component IIB Carbohydrate transport and metabolism 126699763 Common - hypothetical protein CD2146 119 COG1690 RtcB, Uncharacterized conserved protein Function unknown 126700313 Common - hypothetical protein CD2699 11 COG3314 COG3314, Uncharacterized protein conserved in bacteria Function unknown 126700275 Common - probable peptidase CD2661 102 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 126700138 Common leuS leucyl-tRNA synthetase CD2521 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126698575 Common leuD 3-isopropylmalate dehydratase small subunit CD0991 206 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 126699403 Pathogen - hypothetical protein CD1794 1 None None None 126698170 Pathogen - hypothetical protein CD0592 1 None None None 126699300 Common - hypothetical protein CD1694 1 None None None 126698082 Common orf14 putative cell wall hydrolase CD0504 131 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 126697946 Common - conjugative tranposon protein CD0376 15 COG4734 ArdA, Antirestriction protein General function prediction only 126698806 Pathogen - hypothetical protein CD1210 1 None None None 126700576 Common ntpG V-type ATP synthase subunit F CD2956A 10 COG1436 NtpG, Archaeal/vacuolar-type H+-ATPase subunit F Energy production and conversion 126698625 Common addA ATP-dependent nuclease subunit A CD1041 228 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 126699296 Common trxA1 thioredoxin CD1690 235 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 126700338 Common - hypothetical protein CD2723 19 COG0392 COG0392, Predicted integral membrane protein Function unknown 126699134 Common - two-component sensor histidine kinase CD1530 201 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126698820 Common deoD purine nucleoside phosphorylase CD1224 145 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 126698598 Common - two-component system sensor histidine kinase CD1014 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126699017 Common - putative radical SAM-superfamily protein CD1414 88 COG1242 COG1242, Predicted Fe-S oxidoreductase General function prediction only 126700310 Common - putative aminotransferase CD2696 231 COG1168 MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities Amino acid transport and metabolism 126699992 Common - NUDIX-family protein CD2377 25 COG1443 Idi, Isopentenyldiphosphate isomerase Lipid metabolism 126699030 Common - hypothetical protein CD1425 20 COG1285 SapB, Uncharacterized membrane protein Function unknown 126697720 Common - hypothetical protein CD0148 7 None None None 126698052 Pathogen - hypothetical protein CD0476 1 None None None 126698551 Pathogen - hypothetical protein CD0967 1 COG5281 COG5281, Phage-related minor tail protein Function unknown 126698460 Common glgD glycogen biosynthesis protein CD0883 119 COG0448 GlgC, ADP-glucose pyrophosphorylase Carbohydrate transport and metabolism 126699028 Pathogen - hypothetical protein CD1423 1 None None None 126698260 Common - probable transporter CD0681 178 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 126697597 Common - AraC-family transcriptional regulator CD0031 60 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 126698229 Common - hypothetical protein CD0651 7 None None None 126700706 Common - PTS system, IIabc component CD3089 52 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 126698705 Common - putative conjugative transfer protein CD1113 3 None None None 126700236 Common - hypothetical protein CD2622 52 COG1799 COG1799, Uncharacterized protein conserved in bacteria Function unknown 126698012 Pathogen - hypothetical protein CD0439 1 None None None 126698351 Common spoIIAB anti-sigma F factor CD0771 30 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 126700852 Common - hypothetical protein CD3232 35 COG3681 COG3681, Uncharacterized conserved protein Function unknown 126700633 Common - PTS system, IIc component CD3013 67 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 126701155 Common - putative phophoesterase CD3531 116 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 126698543 Common - putative phage tail tape measure protein CD0959 29 COG5281 COG5281, Phage-related minor tail protein Function unknown 126698026 Common - putative DNA repair protein CD0452 63 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 126699172 Common - MarR-family transcriptional regulator CD1569 26 COG1846 MarR, Transcriptional regulators Transcription 126700265 Common murG UDP-N-acetylglucosamine--N-acetylmuramyl-(penta peptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase CD2651 212 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 126700440 Pathogen - hypothetical protein CD2824 1 None None None 126699291 Common - hypothetical protein CD1685 10 COG4912 COG4912, Predicted DNA alkylation repair enzyme DNA replication, recombination, and repair 126699925 Pathogen - hypothetical protein CD2307 1 None None None 126701227 Common - two-component response regulator CD3600 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126698502 Pathogen - hypothetical protein CD0925 1 None None None 126697645 Common rplV 50S ribosomal protein L22 CD0078 239 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 126699174 Common tlpA transposase-like protein A CD1571 2 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 126701077 Common - putative regulatory protein CD3454 26 COG3760 COG3760, Uncharacterized conserved protein Function unknown 126700673 Common - ABC transporter, ATP-binding protein CD3056 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126699373 Common - hypothetical protein CD1764 41 COG3382 COG3382, Uncharacterized conserved protein Function unknown 126699199 Common cysA serine acetyltransferase CD1595 219 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 126698372 Common - hypothetical protein CD0792 6 COG0730 COG0730, Predicted permeases General function prediction only 126699627 Pathogen ermC 23S rRNA methylase leader peptide CD2010A 1 None None None 126699330 Common - hypothetical protein CD1724 3 None None None 126701293 Common - hypothetical protein CD3665 29 COG4481 COG4481, Uncharacterized protein conserved in bacteria Function unknown 126700658 Common - hypothetical protein CD3040 5 None None None 126700285 Common appD oligopeptide transporter, ATP-binding protein CD2671 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 126698720 Common - putative transcriptional regulator CD1126A 77 COG1476 COG1476, Predicted transcriptional regulators Transcription 126701275 Common - PTS system, IIb component CD3648 31 COG1440 CelA, Phosphotransferase system cellobiose-specific component IIB Carbohydrate transport and metabolism 126698383 Common - putative acyl-CoA dehydrogenase CD0803 166 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 126701099 Common atpZ putative ATP synthase protein CD3476 4 None None None 126699504 Common - putative plasmid-related protein CD1894 2 None None None 126700741 Common - putative nitroreductase CD3123 87 COG0778 NfnB, Nitroreductase Energy production and conversion 126700946 Common - conjugative transposon conserved hypothetical protein CD3327 5 None None None 126697632 Common - NADP-dependent 7-alpha-hydroxysteroid dehydrogenase CD0065 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 126700510 Common - putative phage endolysin CD2894 13 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 126698886 Common - metallo beta-lactamase superfamily protein CD1289 159 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 126700976 Common - putative transcriptional regulator CD3356 138 COG1733 COG1733, Predicted transcriptional regulators Transcription 126699656 Common - hypothetical protein CD2039 10 COG1102 Cmk, Cytidylate kinase Nucleotide transport and metabolism 126698058 Common spaR putative lantibiotic resistance two-component response regulator CD0481 221 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126698257 Common - putative transcriptional regulator CD0678 2 None None None 126698217 Common - hypothetical protein CD0639 16 None None None 126697585 Common - putative glycosyl transferase CD0019 38 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 126699344 Common - putative gluconate permease CD1737 67 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 126697669 Common rpoA DNA-directed RNA polymerase alpha chain CD0098 217 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 126697922 Common - putative transcriptional regulator CD0352 105 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 126698051 Common - hypothetical protein CD0475 3 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 126699600 Common - integrase (partial) CD1991 5 None None None 126699750 Common - putative signaling protein CD2134 172 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 126698398 Common - putative 6-phospho-beta-glucosidase CD0818 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 126700994 Pathogen - hypothetical protein CD3372 1 None None None 126698742 Common - hypothetical protein CD1147 8 None None None 126699690 Common xdhA1 xanthine dehydrogenase, molybdenum binding subunit CD2073 118 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 126701010 Common - putative conjugative transposon replication initiation factor CD3388 8 COG2946 COG2946, Putative phage replication protein RstA DNA replication, recombination, and repair 126699630 Common hydR TetR-family transcriptional regulator CD2013 75 COG1309 AcrR, Transcriptional regulator Transcription 126698500 Pathogen - hypothetical protein CD0923 1 None None None 126699410 Common - hypothetical protein CD1801 75 COG1284 COG1284, Uncharacterized conserved protein Function unknown 126699049 Common pabA para-aminobenzoate synthase glutamine amidotransferase component II CD1445 238 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 126700541 Common - phage protein CD2923 6 COG5484 COG5484, Uncharacterized conserved protein Function unknown 126700107 Common - putative peptidase CD2490 59 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 126699339 Common - putative corrinoid protein CD1732 165 COG5012 COG5012, Predicted cobalamin binding protein General function prediction only 126700076 Common glcK glucokinase CD2459 119 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 126699037 Common - putative bifunctional protein: peroxiredoxin/chitinase CD1433 220 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 126699105 Common deoC putative deoxyribose-phosphate aldolase CD1502 138 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 126697763 Common - hypothetical protein CD0190 118 COG2855 COG2855, Predicted membrane protein Function unknown 126701212 Common - ABC transporter, ATP-binding protein CD3585 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126700048 Common glyS glycyl-tRNA synthetase beta chain CD2432 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 126699649 Common argB acetylglutamate kinase CD2032 220 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 126700895 Common - PTS system, IId component CD3276 41 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 126700569 Common - putative phage repressor CD2950 4 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 126701148 Common - putative DNA-binding protein CD3524 21 COG1658 COG1658, Small primase-like proteins (Toprim domain) DNA replication, recombination, and repair 126700113 Common comE putative competence protein CD2497 64 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 126697783 Common - putative choline sulfatase CD0212 6 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 126700196 Common - probable short chain dehydrogenase CD2577 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 126700923 Common clpX ATP-dependent protease ATP-binding subunit CD3304 231 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 126699776 Common - hypothetical protein CD2160 7 COG4767 VanZ, Glycopeptide antibiotics resistance protein Defense mechanisms 126699638 Pathogen - hypothetical protein CD2021 1 None None None 126700631 Common - putative transcriptional regulator CD3011 98 COG1733 COG1733, Predicted transcriptional regulators Transcription 126700916 Common - hypothetical protein CD3297 18 COG3879 COG3879, Uncharacterized protein conserved in bacteria Function unknown 126697713 Common - putative copper homeostasis protein CD0141 59 COG3142 CutC, Uncharacterized protein involved in copper resistance Inorganic ion transport and metabolism 126700125 Common - probable 6-phospho-alpha-glucosidase CD2509 49 COG1486 CelF, Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases Carbohydrate transport and metabolism 126700587 Pathogen - hypothetical protein CD2966A 1 None None None 126698128 Pathogen - hypothetical protein CD0549 1 None None None 126698455 Common - ABC transporter, permease protein CD0878 122 COG4120 COG4120, ABC-type uncharacterized transport system, permease component General function prediction only 126699672 Pathogen - hypothetical protein CD2055 1 None None None 126700079 Common grpE heat shock protein CD2462 232 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 126700455 Common - putative two-component sensor histidine kinase CD2839 103 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 126700582 Pathogen - hypothetical protein CD2962 1 None None None 126700483 Common tldD putative regulatory protease CD2867 169 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 126698492 Pathogen - hypothetical protein CD0915 1 None None None 126699617 Pathogen - hypothetical protein CD2005 6 None None None 126699484 Common - putative iron-sulfur-binding membrane protein CD1872 74 COG0348 NapH, Polyferredoxin Energy production and conversion 126699423 Common - hypothetical protein CD1815 142 COG2081 COG2081, Predicted flavoproteins General function prediction only 126699932 Common - hypothetical protein CD2314 10 COG2014 COG2014, Uncharacterized conserved protein Function unknown 126699624 Common - putative topoisomerase (partial) CD2009 18 COG1933 COG1933, Archaeal DNA polymerase II, large subunit DNA replication, recombination, and repair 126699398 Common - hypothetical protein CD1789 69 COG2323 COG2323, Predicted membrane protein Function unknown 126700591 Common - putative thiolase CD2970 168 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 126698624 Common addB ATP-dependent nuclease subunit B CD1040 29 COG3857 AddB, ATP-dependent nuclease, subunit B DNA replication, recombination, and repair 126697656 Common rplR 50S ribosomal protein L18 CD0087 218 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 126697592 Common clpC ATP-dependent Clp protease CD0026 239 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 126698379 Common act putative beta-alanine CoA-transferase CD0799 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 126699357 Common hgdC putative (R)-2-hydroxyglutaryl-CoA dehydratase alpha-subunit CD1750 65 COG1924 COG1924, Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) Lipid metabolism 126700847 Common dapD 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase CD3227 139 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 126700353 Common - putative cytosine permease CD2738 63 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 126699714 Common - hypothetical protein CD2097 18 COG4708 COG4708, Predicted membrane protein Function unknown 126697956 Common - putative collagen-binding surface protein CD0386 9 COG4932 COG4932, Predicted outer membrane protein Cell envelope biogenesis, outer membrane 126698065 Common sugE quaternary ammonium compound-resistance protein CD0488 131 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 126698966 Pathogen - hypothetical protein CD1365A 1 None None None 126698677 Common int integrase CD1091 195 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 126699021 Common - putative drug/sodium antiporter CD1418 116 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 126699912 Common - hypothetical protein CD2296 1 None None None 126698415 Common - MarR-family transcriptional regulator CD0835 45 COG1846 MarR, Transcriptional regulators Transcription 126698978 Pathogen - hypothetical protein CD1377 1 None None None 126701092 Common atpG ATP synthase subunit gamma CD3469 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 126698407 Common rbo rubredoxin oxidoreductase (desulfoferrodoxin) CD0827 28 COG2033 COG2033, Desulfoferrodoxin Energy production and conversion 126700734 Common bglG putative beta-glucoside bgl operon transcription antiterminator CD3117 29 COG3711 BglG, Transcriptional antiterminator Transcription 126699497 Common - PadR-family transcriptional regulator CD1886 7 COG1695 COG1695, Predicted transcriptional regulators Transcription 126699939 Common tkt' transketolase CD2321 231 COG3958 COG3958, Transketolase, C-terminal subunit Carbohydrate transport and metabolism 126700176 Common coaD phosphopantetheine adenylyltransferase CD2558 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 126697764 Common - putative DNA glycosylase (DNA repair protein) CD0191 33 COG0122 AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 126699042 Common - putative multiprotein complex assembly protein CD1438 1 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 126700840 Common - small acid-soluble spore protein CD3220A 8 None None None 126698924 Common - tRNA 2-selenouridine synthase CD1325 65 COG2603 COG2603, Predicted ATPase General function prediction only 126698497 Pathogen - hypothetical protein CD0920 1 None None None 126699707 Common - putative xanthine/uracile permease CD2090 126 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 126698072 Common orf23 conjugative transposon protein CD0496 6 None None None 126698803 Common dxs 1-deoxy-D-xylulose 5-phosphate synthase CD1207 226 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 126698958 Common - putative phage-related protein CD1359 2 None None None 126698473 Pathogen - hypothetical protein CD0896 1 None None None 126698573 Common leuA 2-isopropylmalate synthase CD0989 211 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 126698437 Common - hypothetical protein CD0860 4 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 126699557 Common - putative ABC transporter, permease protein CD1948 52 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126699686 Common - putative molybdopterin biosynthesis protein CD2069 83 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 126700820 Common - ABC transporter, ATP-binding protein CD3201 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126698813 Common - putative glycosyltransferase CD1217 190 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 126698042 Common - RpiR-family transcriptional regulator CD0466 28 COG1737 RpiR, Transcriptional regulators Transcription 126701282 Common purA adenylosuccinate synthetase CD3655 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 126698859 Common rnhB ribonuclease HII CD1262 225 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 126699834 Common aroD 3-dehydroquinate dehydratase CD2217 54 COG0710 AroD, 3-dehydroquinate dehydratase Amino acid transport and metabolism 126698182 Common - hypothetical protein CD0604 10 None None None 126700612 Common - putative ABC transporter, permease protein CD2991 196 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 126701123 Common spoVT stage V sporulation protein T CD3499 16 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 126700811 Common - cell surface protein CD3192 7 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126697883 Pathogen - hypothetical protein CD0311 1 None None None 126699793 Common - probable amino-acid ABC transporter,substrate-binding protein CD2177 162 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 126699432 Common - putative cations-transporting ATPase CD1824 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 126700259 Common - putative extracellular solute-binding protein CD2645 100 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 126700446 Common - hypothetical protein CD2830 2 None None None 126700250 Common - hypothetical protein CD2636 9 None None None 126701217 Common carB carbamoyl phosphate synthase large subunit CD3590 237 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 126700477 Common - hypothetical protein CD2861 7 None None None 126697876 Common - hypothetical protein CD0304 14 COG5426 COG5426, Uncharacterized membrane protein Function unknown 126699919 Common tlpB' transposase-like protein B CD2302 72 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 126698034 Common - putative beta-lactamase CD0458 38 COG2602 COG2602, Beta-lactamase class D Defense mechanisms 126700416 Common - hypothetical protein CD2800 1 None None None 126699147 Common - putative acyl carrier protein phosphodiesterase CD1543 67 COG1182 AcpD, Acyl carrier protein phosphodiesterase Lipid metabolism 126700988 Common - putative GTPase CD3368 162 COG1162 COG1162, Predicted GTPases General function prediction only 126697757 Common pyrB aspartate carbamoyltransferase catalytic chain CD0184 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 126698764 Common - GntR-family transcriptional regulator CD1169 150 COG2186 FadR, Transcriptional regulators Transcription 126699591 Common - putative transcriptional regulator CD1981 138 COG1733 COG1733, Predicted transcriptional regulators Transcription 126699529 Common eutT putative ethanolamine/propanediol utilization cobalamin adenosyltransferase CD1919 12 COG4812 EutT, Ethanolamine utilization cobalamin adenosyltransferase Amino acid transport and metabolism 126697710 Common - hypothetical protein CD0138 9 None None None 126698339 Common plfB formate acetyltransferase CD0759 58 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 126701041 Common - putative siroheme synthase CD3418 114 COG1648 CysG, Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) Coenzyme metabolism 126699004 Common glpQ glycerophosphoryl diester phosphodiesterase CD1402 165 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 126700411 Common - cell surface protein CD2795 12 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 126698715 Common - putative phosphoesterase CD1123 100 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 126699528 Common eutM putative ethanolamine/propanediol utilization protein CD1918 46 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 126698927 Common recA RecA protein (recombinase A) CD1328 216 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 126698907 Common - putative ribosomal protein CD1308 30 COG1358 RPL8A, Ribosomal protein HS6-type (S12/L30/L7a) Translation, ribosomal structure and biogenesis 126701205 Common - putative resolvase CD3578 117 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 126698294 Common - probable sugar O-acetyltransferase (partial) CD0714A 76 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 126700602 Common - hypothetical protein CD2981 6 None None None 126699893 Common araD L-ribulose-5-phosphate 4-epimerase CD2278 119 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 126697609 Common - PTS system, IIc component CD0043 19 COG3775 GatC, Phosphotransferase system, galactitol-specific IIC component Carbohydrate transport and metabolism 126701073 Common - putative oxidoreductase CD3450 148 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 126701307 Common rnpA ribonuclease P CD3679 104 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 126699788 Common - probable amino-acid ABC transporter, ATP-binding protein CD2172 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 126699781 Common - hypothetical protein CD2165 42 COG2856 COG2856, Predicted Zn peptidase Amino acid transport and metabolism 126697730 Common - putative two-component response regulator CD0160 86 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 126701050 Common cbiT cobalt-precorrin-6Y C(15)-methyltransferase CD3427 120 COG2242 CobL, Precorrin-6B methylase 2 Coenzyme metabolism 126700518 Common - phage protein CD2901 6 None None None 126700656 Common - hypothetical protein CD3038 19 COG3864 COG3864, Uncharacterized protein conserved in bacteria Function unknown 126698362 Common - hypothetical protein CD0782 14 None None None 126699603 Common - putative decarboxylase CD1993 69 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 126697903 Common ppiB peptidyl-prolyl cis-trans isomerase CD0331 201 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 126699465 Common - putative conjugal transfer protein CD1856 45 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 126700502 Common - putative drug/sodium antiporter CD2886 187 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 126699968 Common grdB glycine reductase complex component B gamma subunit CD2351 8 None None None 126698868 Common - hypothetical protein CD1271 144 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 126699864 Common cspC putative germination-specific protease CD2246 8 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 126700887 Common - putative phosphate ABC transporter,substrate-binding protein CD3268 178 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 126701038 Common - ABC transporter, permease protein CD3415 147 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 126700216 Common - putative pseudouridylate synthase CD2596 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 126697580 Common serS1 seryl-tRNA synthetase CD0014 243 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 126700765 Pathogen - hypothetical protein CD3148 1 None None None 126700470 Common dltD putative D-alanine transferase CD2854 13 COG3966 DltD, Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) Cell envelope biogenesis, outer membrane 126700885 Common - two-component sensor histidine kinase CD3266 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126698583 Common - ABC transporter, substrate-binding lipoprotein CD0999 33 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 126698008 Common - putative recombinase CD0436 87 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 126697726 Pathogen hpdC 4-hydroxyphenylacetate decarboxylase, regulatory subunit CD0154 1 None None None 126698726 Common - putative heavy-metal binding protein CD1132 21 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 126699751 Common cdsA putative phosphatidate cytidylyltransferase CD2135 215 COG4589 COG4589, Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase General function prediction only 126698523 Common - putative phage DNA-binding protein CD0943 6 COG5484 COG5484, Uncharacterized conserved protein Function unknown 126700890 Pathogen - hypothetical protein CD3271 1 None None None 126699598 Common - hypothetical protein CD1990 2 None None None 126700719 Common - putative dipeptidase CD3102 70 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 126701127 Common - putative type IV prepilin leader peptidase CD3503 4 None None None 126700390 Common - putative teichuronic acid biosynthesis glycosyl transferase CD2774 211 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 126700661 Common - hypothetical protein CD3043 1 COG5279 CYK3, Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain Cell division and chromosome partitioning 126700220 Common - putative carbon starvation CD2600 109 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 126700167 Common - putative sugar transporter, substrate-binding lipoprotein CD2550 107 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 126698448 Common modC putative molybdenum ABC transporter, ATP-binding protein CD0871 249 COG1118 CysA, ABC-type sulfate/molybdate transport systems, ATPase component Inorganic ion transport and metabolism 126701179 Common greA transcription elongation factor CD3553 203 COG0782 GreA, Transcription elongation factor Transcription 126698548 Common - phage protein CD0964 9 COG3299 XkdT, Uncharacterized homolog of phage Mu protein gp47 Function unknown 126698798 Common gcp probable O-sialoglycoprotein endopeptidase CD1202 92 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 126699332 Common - hypothetical protein CD1726 1 None None None 126700932 Common hydN1 electron transport protein CD3313 143 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 126701136 Common - type IV pilus assembly protein CD3512 218 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 126700394 Common - putative polysaccharide biosynthesis protein CD2778 10 COG3774 OCH1, Mannosyltransferase OCH1 and related enzymes Cell envelope biogenesis, outer membrane 126699099 Common proC1 pyrroline-5-carboxylate reductase CD1495 214 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 126697819 Common fliF flagellar MS-ring protein CD0248 125 COG1766 FliF, Flagellar biosynthesis/type III secretory pathway lipoprotein Cell motility and secretion / Intracellular trafficking and secretion 126701234 Common - putative amidohydrolase CD3606 35 COG3964 COG3964, Predicted amidohydrolase General function prediction only 126700123 Common - hypothetical protein CD2507 10 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 126700509 Pathogen - hypothetical protein CD2893 1 None None None 126701169 Common - hypothetical protein CD3545 17 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 126701059 Common - putative cobalamin biosynthesis phosphoglycerate mutase CD3436 102 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 126698852 Common rimM putative 16S rRNA processing protein CD1255 194 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 126698777 Common fabD malonyl CoA-acyl carrier protein transacylase CD1181 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 126699113 Pathogen - putative lipoprotein CD1509 1 None None None 126698212 Common - hypothetical protein CD0634 4 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 126700291 Common ctfA butyrate--acetoacetate CoA-transferase subunit A CD2677 98 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 126698552 Pathogen - hypothetical protein CD0968 1 None None None 126700710 Common - putative glutamine amidotransferase CD3093 128 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 126699988 Common - putative carbon starvation protein CD2373 104 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 126700208 Common gmk guanylate kinase CD2588 214 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 126697790 Common purC phosphoribosylaminoimidazole-succinocarboxamide synthase CD0219 210 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 126698562 Pathogen - hypothetical protein CD0977A 1 None None None 126699570 Common - ABC transporter, ATP-binding protein CD1961 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126699244 Common - hypothetical protein CD1640 23 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 126701266 Common - LysR-family transcriptional regulator CD3639 191 COG0583 LysR, Transcriptional regulator Transcription 126700438 Common - putative peptidase CD2822 170 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 126701265 Common - hypothetical protein CD3638 16 COG5276 COG5276, Uncharacterized conserved protein Function unknown 126701104 Common - low molecular weight protein-tyrosine-phosphatase CD3481 133 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 126699445 Common pheA P-protein CD1836 214 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 126699836 Common - conjugative transposon protein (partial) CD2219 12 None None None 126699850 Common asrA anaerobic sulfite reductase subunit A CD2233 31 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 126698308 Common - bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta CD0728 19 COG1614 CdhC, CO dehydrogenase/acetyl-CoA synthase beta subunit Energy production and conversion 126698898 Common - hypothetical protein CD1301 1 COG5522 COG5522, Predicted integral membrane protein Function unknown 126698606 Common - hypothetical protein CD1022 29 COG2364 COG2364, Predicted membrane protein Function unknown 126700229 Common - TetR-family trancscriptional regulator CD2615 67 COG1309 AcrR, Transcriptional regulator Transcription 126699804 Common mapA maltose phosphorylase CD2188 50 COG1554 ATH1, Trehalose and maltose hydrolases (possible phosphorylases) Carbohydrate transport and metabolism 126699094 Common metI putative D-methionine ABC transporter, permease protein CD1490 129 COG2011 AbcD, ABC-type metal ion transport system, permease component Inorganic ion transport and metabolism 126698114 Common cheD chemotaxis protein CD0535 86 COG1871 CheD, Chemotaxis protein; stimulates methylation of MCP proteins Cell motility and secretion / Signal transduction mechanisms 126697967 Common hadC subunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase CD0398 36 COG1775 HgdB, Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB Amino acid transport and metabolism 126697837 Common fleN flagellar number regulator CD0265 232 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 126700989 Common - hypothetical protein CD3368A 5 None None None 126698462 Common glgP glycogen phosphorylase CD0885 135 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 126700151 Common - ABC transporter ATP-binding protein CD2534 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126700855 Common - single-strand DNA-binding protein CD3235 13 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 126697718 Common - putative amidohydrolase CD0146 49 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 126699298 Common - ArsR-family transcriptional regulator CD1692 88 COG0640 ArsR, Predicted transcriptional regulators Transcription 126698536 Common - phage protein CD0954 6 None None None 126699511 Common - putative phage repressor CD1901 23 COG1396 HipB, Predicted transcriptional regulators Transcription 126700878 Common - hypothetical protein CD3259 7 COG4129 COG4129, Predicted membrane protein Function unknown 126701259 Common - hypothetical protein CD3633 22 None None None 126700472 Common - hypothetical protein CD2856 12 COG4905 COG4905, Predicted membrane protein Function unknown 126698776 Common fabK trans-2-enoyl-ACP reductase CD1180 148 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 126699743 Common - hypothetical protein CD2126 7 None None None 126700699 Common - PTS system, IIb component CD3082 32 COG1440 CelA, Phosphotransferase system cellobiose-specific component IIB Carbohydrate transport and metabolism 126699252 Common - putative iron compound ABC transporter, permease protein CD1648 174 COG4605 CeuC, ABC-type enterochelin transport system, permease component Inorganic ion transport and metabolism 126700778 Common - putative acetyltransferase CD3159 8 COG0456 RimI, Acetyltransferases General function prediction only 126699284 Pathogen - hypothetical protein CD1678A 1 None None None 126698262 Common - LacI-family transcriptional regulator CD0683 129 COG1609 PurR, Transcriptional regulators Transcription 126698311 Common - putative radical SAM superfamily protein CD0731 17 COG1856 COG1856, Uncharacterized homolog of biotin synthetase Function unknown 126701178 Common lysS lysyl-tRNA synthetase CD3552 248 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 126700345 Common - hypothetical protein CD2730 114 COG1937 COG1937, Uncharacterized protein conserved in bacteria Function unknown 126698113 Common cheC chemotaxis protein CheC CD0534 36 COG1776 CheC, Chemotaxis protein CheC, inhibitor of MCP methylation Cell motility and secretion / Signal transduction mechanisms 126698592 Common - hypothetical protein CD1008 44 COG2996 COG2996, Uncharacterized protein conserved in bacteria Function unknown 126699379 Common ogt2 methylated-DNA--protein-cysteine methyltransferase 2 CD1770 212 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 126700234 Common - putative RNA-binding cell division protein CD2620 32 COG2302 COG2302, Uncharacterized conserved protein, contains S4-like domain Function unknown 126698386 Common - putative sigma-54-dependent transcriptional regulator CD0806 166 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 126698263 Common - putative ATP-dependent peptidase CD0684 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 126700155 Common - putative lipoprotein CD2538 9 None None None 126698787 Common fbp putative fructose-1,6-bisphosphatase CD1191 18 COG3855 Fbp, Uncharacterized protein conserved in bacteria Carbohydrate transport and metabolism 126698208 Common - putative drug/sodium antiporter CD0630 126 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 126700788 Common - putative transporter CD3169 144 COG0679 COG0679, Predicted permeases General function prediction only 126700201 Common - putative membrane-associated neutral zinc metallopeptidase CD2582 42 COG2738 COG2738, Predicted Zn-dependent protease General function prediction only 126698786 Common - putative acetyltransferase CD1190 64 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 126699091 Common - hypothetical protein CD1487 6 None None None 126700263 Common - hypothetical protein CD2649 19 COG3879 COG3879, Uncharacterized protein conserved in bacteria Function unknown 126699957 Common abfT 4-hydroxybutyrate CoA transferase CD2339 104 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 126700129 Common - putative translation inhibitor endoribonuclease CD2513 200 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 126701133 Pathogen - putative type IV pilus assembly protein CD3509 1 None None None 126699323 Common - probable permease CD1716 71 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 126698882 Common - putative holliday junction resolvase CD1285 183 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 126699500 Common - ABC transporter, ATP-binding protein CD1889 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126697727 Common hpdA 4-hydroxyphenylacetate decarboxylase, activating subunit CD0155 60 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 126699687 Common - putative molybdopterin-guanine dinucleotide biosynthesis protein CD2070 39 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 126698105 Common - putative peptidase CD0524 105 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 126699416 Common - putative NADPH-dependent FMN reductase CD1807 44 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 126700341 Common glyA putative serine hydroxymethyltransferase CD2726 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 126700830 Common - hypothetical protein CD3211 5 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 126700992 Common - putative conjugative transposon excisionase CD3370A 4 None None None 126700316 Common brnQ putative branched-chain amino acid transport system carrier protein CD2702 50 COG1114 BrnQ, Branched-chain amino acid permeases Amino acid transport and metabolism 126700707 Common treR GntR-family transcriptional regulator CD3090 102 COG2188 PhnF, Transcriptional regulators Transcription 126699397 Common - hypothetical protein CD1788 5 None None None 126701229 Common - putative ATPase CD3602 161 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 126700360 Common apt adenine phosphoribosyltransferase CD2745 189 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 126701252 Common kdgA 2-keto-3-deoxy-6-phospho-gluconate aldolase CD3626 126 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 126699799 Common csdA ATP-dependent RNA helicase CD2183 239 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 126697887 Pathogen - hypothetical protein CD0315 1 None None None 126697772 Common - putative chromate transporter CD0201 68 COG2059 ChrA, Chromate transport protein ChrA Inorganic ion transport and metabolism 126700454 Common - putative two-component response regulator CD2838 210 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 126697919 Pathogen - hypothetical protein CD0347 1 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 126698369 Common - hypothetical protein CD0789 3 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 126700908 Pathogen - hypothetical protein CD3289 1 None None None 126699780 Common ldh L-lactate dehydrogenase CD2164 158 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 126697994 Common - putative helicase CD0423 60 COG4646 COG4646, DNA methylase Transcription / DNA replication, recombination, and repair 126699214 Common - hypothetical protein CD1610 3 None None None 126697895 Common - hypothetical protein CD0323 12 COG4548 NorD, Nitric oxide reductase activation protein Inorganic ion transport and metabolism 126698138 Common - hypothetical protein CD0559 10 COG4189 COG4189, Predicted transcriptional regulator Transcription 126701001 Pathogen - hypothetical protein CD3378 1 None None None 126699102 Common rpoD2 RNA polymerase sigma factor rpoD CD1498 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 126700059 Pathogen - hypothetical protein CD2443 1 None None None 126700610 Common - ABC transporter, substrate-binding protein CD2989 104 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 126699110 Common - putative thioredoxin CD1507 50 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 126701154 Common - putative iron ABC transporter, ATP-binding protein CD3530 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 126700979 Common - ABC transporter, ATP-binding protein CD3359 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 126699176 Common - putative transcriptional regulator CD1573 27 COG1476 COG1476, Predicted transcriptional regulators Transcription 126699376 Common gapA glyceraldehyde-3-phosphate dehydrogenase 1 CD1767 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 126700131 Common aspD aspartate aminotransferase CD2515 131 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 126700240 Common - hypothetical protein CD2626 48 COG2848 COG2848, Uncharacterized conserved protein Function unknown 126699844 Common - putative radical SAM superfamily lipoprotein CD2227 74 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 126699929 Common - ABC transporter, substrate-binding protein0 CD2311 86 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 126699668 Common - hypothetical protein CD2051 195 COG0628 PerM, Predicted permease General function prediction only 126700479 Common - putative sigma-54-dependent transcriptional regulator CD2863 168 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 126697850 Common - putative transcriptional regulator CD0278 148 COG1733 COG1733, Predicted transcriptional regulators Transcription 126700520 Common - putative phage cell wall hydrolase CD2903 126 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 126698659 Common - putative aminopeptidase 1 CD1072 44 COG1362 LAP4, Aspartyl aminopeptidase Amino acid transport and metabolism 126699812 Common - putative acetyl-CoA synthetase CD2196 140 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 126700303 Common - putative lipoprotein CD2689 142 COG2081 COG2081, Predicted flavoproteins General function prediction only 126699039 Pathogen - hypothetical protein CD1435 1 None None None 126698725 Common - putative solute-binding lipoprotein CD1131 167 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 126701079 Common - putative 5-formyltetrahydrofolate cyclo-ligase CD3456 191 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 126698248 Common - two-component sensor histidine kinase CD0669 212 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126698638 Common bcd2 butyryl-CoA dehydrogenase CD1054 170 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 126698561 Pathogen - hypothetical protein CD0977 1 None None None 126700600 Common - hypothetical protein CD2979 8 COG1688 COG1688, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 126699083 Common feoB1 ferrous iron transport protein B CD1479 173 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 126697795 Common purD phosphoribosylamine--glycine ligase CD0224 235 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 126700952 Common - hypothetical protein CD3333 8 COG3070 TfoX, Regulator of competence-specific genes Transcription 126698893 Common scpB segregation and condensation protein B CD1296 149 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 126699903 Common - two-component sensor histidine kinase CD2288 218 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 126700428 Common - putative gluconate permease CD2812 79 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 126700556 Pathogen - hypothetical protein CD2938 1 None None None 126700566 Pathogen - hypothetical protein CD2947A 1 None None None 126698733 Common rnfG electron transport complex protein CD1139 41 COG4659 RnfG, Predicted NADH:ubiquinone oxidoreductase, subunit RnfG Energy production and conversion 126699431 Common - hypothetical protein CD1823 84 COG3022 COG3022, Uncharacterized protein conserved in bacteria Function unknown 126699222 Common - ABC transporter, ATP-binding protein CD1618 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126700306 Common - putative aminotransferase CD2692 236 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 126699696 Common xdhA2 xanthine dehydrogenase, molybdenum binding subunit CD2079 112 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 126700968 Common - hypothetical protein CD3348 14 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 126700109 Common - putative sensor histidine kinase CD2492 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126697914 Pathogen - hypothetical protein CD0342 1 None None None 126698694 Pathogen - hypothetical protein CD1104B 1 None None None 126700531 Common - phage protein CD2912 2 None None None 126699705 Common cutS putative carbon monoxide dehydrogenase,iron-sulfur-binding subunit CD2088 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 126700252 Common - two-component response regulator CD2638 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126700744 Common bglG2 transcription antiterminator CD3126 29 COG3711 BglG, Transcriptional antiterminator Transcription 126701167 Common - putative nicotinate phosphribosyltransferase CD3543 105 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 126698356 Common - LacI-family transcriptional regulator CD0776 123 COG1609 PurR, Transcriptional regulators Transcription 126700190 Common - two-component response regulator CD2571 219 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126699120 Common - MerR-family transcriptional activator CD1516 47 COG0789 SoxR, Predicted transcriptional regulators Transcription 126699206 Common - PTS system, IIb component CD1602 31 COG1440 CelA, Phosphotransferase system cellobiose-specific component IIB Carbohydrate transport and metabolism 126699306 Common ribD riboflavin biosynthesis protein CD1700 233 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 126700491 Common fhuC putative ferrichrome ABC transporter,ATP-binding protein CD2875 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 126700020 Common - MarR-family transcriptional regulator CD2405 1 COG1846 MarR, Transcriptional regulators Transcription 126700686 Common - PTS system, IId component CD3069 40 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 126697616 Common - prolyl-tRNA synthetase CD0050 157 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126697848 Common - AraC-family transcriptional regulator CD0276 134 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 126700873 Common - putative serine protease CD3254 36 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 126698860 Common - putative FMN-dependent dehydrogenase CD1263 166 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 126697986 Pathogen - hypothetical protein CD0416 1 None None None 126698307 Common - putative carbon monoxide dehydrogenase/acetyl-CoA synthase complex,methyltransferase subunit CD0727 159 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 126698941 Common - putative exonuclease CD1342 9 COG5018 KapD, Inhibitor of the KinA pathway to sporulation, predicted exonuclease General function prediction only 126700697 Common - PTS system, IIa component CD3080 31 COG1447 CelC, Phosphotransferase system cellobiose-specific component IIA Carbohydrate transport and metabolism 126699747 Common dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase CD2130 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 126698870 Common - putative competence protein CD1273 211 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 126699887 Common - hypothetical protein CD2272 50 COG2365 COG2365, Protein tyrosine/serine phosphatase Signal transduction mechanisms 126698641 Common crt2 3-hydroxybutyryl-CoA dehydratase CD1057 189 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 126699421 Common - hypothetical protein CD1813 1 COG4728 COG4728, Uncharacterized protein conserved in bacteria Function unknown 126700750 Common - PTS system, IIa component CD3132 126 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 126699923 Common - transposase (partial) CD2305A 8 None None None 126697808 Common fliD flagellar cap protein CD0237 46 COG1345 FliD, Flagellar capping protein Cell motility and secretion 126698946 Pathogen - hypothetical protein CD1347 1 None None None 126698151 Common - putative membrane protin CD0573 24 COG4399 COG4399, Uncharacterized protein conserved in bacteria Function unknown 126700221 Common - two-component response regulator CD2601 198 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 126697966 Common hadB subunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase CD0397 14 COG1775 HgdB, Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB Amino acid transport and metabolism 126700724 Common - putative transcription antiterminator CD3107 32 COG3711 BglG, Transcriptional antiterminator Transcription 126699948 Common xpt xanthine phosphoribosyltransferase CD2330 61 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 126697702 Common metE S-adenosylmethionine synthetase CD0130 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 126700624 Common - probable carbohydrate hydrolase (N-terminus) CD3003 63 COG2721 UxaA, Altronate dehydratase Carbohydrate transport and metabolism 126698605 Common - hypothetical protein CD1021 20 COG5337 CotH, Spore coat assembly protein Cell envelope biogenesis, outer membrane 126699742 Common - putative acetyltransferase CD2125 99 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 126699966 Common grdD glycine/sarcosine/betaine reductase complex component C alpha subunit CD2348 14 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 126698970 Pathogen - hypothetical protein CD1369 1 None None None 126699851 Common - cAMP-binding regulatory protein CD2234 121 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 126698545 Common - putative phage cell wall hydrolase CD0961 126 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 126698968 Common - hypothetical protein CD1367 5 None None None 126700320 Common - hypothetical protein CD2706 9 None None None 126699870 Common kamA L-lysine 2,3-aminomutase CD2252 127 COG1509 KamA, Lysine 2,3-aminomutase Amino acid transport and metabolism 126700747 Common - putative glycosyl hydrolase CD3129 50 COG1554 ATH1, Trehalose and maltose hydrolases (possible phosphorylases) Carbohydrate transport and metabolism 126699259 Common - putative Na+/H+ antiporter CD1655 69 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 126700270 Common spoVD stage V sporulation protein D (sporulation specific penicillin-binding protein) CD2656 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 126699767 Common - hypothetical protein CD2151 27 COG5505 COG5505, Predicted integral membrane protein Function unknown 126700592 Common bioY putative biotin synthase CD2971 94 COG1268 BioY, Uncharacterized conserved protein General function prediction only 126701132 Pathogen - putative type IV pilin CD3508 1 COG4795 PulJ, Type II secretory pathway, component PulJ Intracellular trafficking and secretion 126699534 Common eutH putative ethanolamine/propanediol transporter CD1924 19 COG3192 EutH, Ethanolamine utilization protein Amino acid transport and metabolism 126700580 Common ntpI V-type sodium ATP synthase subunit I CD2960 51 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 126698080 Common orf16 conjugative transposon ATP/GTP-binding protein CD0502 18 COG0433 COG0433, Predicted ATPase General function prediction only 126699454 Pathogen - putative membrane protein (partial) CD1845 1 None None None 126701032 Common hprK HPr kinase/phosphorylase CD3409 75 COG1493 HprK, Serine kinase of the HPr protein, regulates carbohydrate metabolism Signal transduction mechanisms 126700634 Common - PTS system, IIb component CD3014 68 COG1445 FrwB, Phosphotransferase system fructose-specific component IIB Carbohydrate transport and metabolism 126699787 Common - putative Sodium:dicarboxylate symporter CD2171 155 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 126699502 Common - hypothetical protein CD1892 102 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 126700050 Common - hypothetical protein CD2434 6 None None None 126697840 Common flgG flagellar basal body rod protein FlgG CD0268 125 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 126698822 Common - putative exported aminodeoxychorismate lyase CD1226 186 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 126701163 Common - putative deoxyribonuclease CD3539 239 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 126698834 Pathogen - hypothetical protein CD1238 1 None None None 126700925 Common tig trigger factor CD3306 215 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 126699488 Common vncR two-component system, response regulator CD1876 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126700027 Common - hypothetical protein CD2412 46 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 126697699 Common mreB1 rod shape-determining protein CD0127 226 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 126700512 Common - hypothetical protein CD2895 2 None None None 126701023 Common - hypothetical protein CD3400 140 COG1660 COG1660, Predicted P-loop-containing kinase General function prediction only 126698580 Common - hypothetical protein CD0996 48 COG4198 COG4198, Uncharacterized conserved protein Function unknown 126699647 Common argF ornithine carbamoyltransferase CD2030 238 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 126700607 Common bacA2 undecaprenyl pyrophosphate phosphatase CD2986 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 126699157 Common hisF putative imidazole glycerol phosphate synthase subunit CD1553 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 126699822 Common - hypothetical protein CD2205 167 COG0628 PerM, Predicted permease General function prediction only 126700827 Common - MarR-family transcriptional regulator CD3208 60 COG1846 MarR, Transcriptional regulators Transcription 126699227 Common - putative nitric oxide reductase flavoprotein CD1623 243 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 126700974 Common - hypothetical protein CD3354 3 COG3382 COG3382, Uncharacterized conserved protein Function unknown 126699367 Common - hypothetical protein CD1759 86 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 126697802 Common flgK putative flagellar hook-associated protein CD0231 128 COG1256 FlgK, Flagellar hook-associated protein Cell motility and secretion 126700700 Common - transcription antiterminator CD3083 36 COG3711 BglG, Transcriptional antiterminator Transcription 126700309 Common asnA asparagine synthetase AsnA CD2695 31 COG2502 AsnA, Asparagine synthetase A Amino acid transport and metabolism 126699260 Common - hypothetical protein CD1656 4 None None None 126697596 Common - hypothetical protein CD0030 9 None None None 126698993 Common - putative esterase CD1391 70 COG2936 COG2936, Predicted acyl esterases General function prediction only 126701185 Common ftsH2 cell division protein CD3559 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 126699493 Common - site-specific recombinase CD1882 89 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 126698089 Pathogen orf10 putative conjugative transposon protein CD0509A 1 None None None 126697857 Common - PTS system, IIb component CD0285 40 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 126700857 Common prdF putative proline racemase CD3237 47 COG3938 COG3938, Proline racemase Amino acid transport and metabolism 126700862 Common - hypothetical protein CD3243 2 None None None 126699472 Common - conjugative transposon O-methyltransferase CD1861 31 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 126699862 Common asnC asparaginyl-tRNA synthetase CD2245 238 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 126698933 Common - adenylosuccinate lyase CD1334 203 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 126700957 Common - conjugative transposon membrane protein CD3337 6 COG5438 COG5438, Predicted multitransmembrane protein Function unknown 126700328 Common galE UDP-glucose 4-epimerase CD2714 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 126701196 Common - probable dipeptidase CD3570 104 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 126700387 Common rkpK putative UDP-glucose 6-dehydrogenase CD2771 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 126700164 Common - hypothetical protein CD2547 6 None None None 126700062 Common GatB/Yqey putative tRNA binding protein CD2446 151 COG1610 COG1610, Uncharacterized conserved protein Function unknown 126699060 Common - hypothetical protein CD1456 29 COG2384 COG2384, Predicted SAM-dependent methyltransferase General function prediction only 126699765 Common - hypothetical protein CD2149 37 COG2720 COG2720, Uncharacterized vancomycin resistance protein Defense mechanisms 126697573 Common - hypothetical protein CD0007 2 COG4980 GvpP, Gas vesicle protein General function prediction only 126697978 Common - putative replication initiation protein CD0409 8 None None None 126697813 Common - hypothetical protein CD0242 14 COG1213 COG1213, Predicted sugar nucleotidyltransferases Cell envelope biogenesis, outer membrane 126698387 Pathogen - hypothetical protein CD0807 1 None None None 126699233 Common - hypothetical protein CD1629 6 COG0398 COG0398, Uncharacterized conserved protein Function unknown 126699731 Common - two-component system response regulator CD2114 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126700003 Common - putative peptidoglycan-binding/hydrolysing protein CD2388 29 COG3409 COG3409, Putative peptidoglycan-binding domain-containing protein Cell envelope biogenesis, outer membrane 126699590 Common - hypothetical protein CD1980A 26 COG0011 COG0011, Uncharacterized conserved protein Function unknown 126698719 Common - AraC-family transcriptional regulator CD1126 84 COG3708 COG3708, Uncharacterized protein conserved in bacteria Function unknown 126699146 Common - hypothetical protein CD1542 26 COG3177 COG3177, Uncharacterized conserved protein Function unknown 126697611 Common - putative sugar-phosphate aldolase CD0045 139 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 126698200 Pathogen - hypothetical protein CD0623 1 None None None 126698424 Common - cell surface protein CD0844 6 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126700297 Common - putative propanediol utilization protein CD2683 36 COG4869 PduL, Propanediol utilization protein Secondary metabolites biosynthesis, transport, and catabolism 126699313 Common thiE2 putative thiamine biosynthesis protein CD1706 65 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 126700463 Common - hypothetical protein CD2847 4 None None None 126700033 Common srlA PTS system, glucitol/sorbitol-specific IIc2 component CD2418 22 COG3730 SrlA, Phosphotransferase system sorbitol-specific component IIC Carbohydrate transport and metabolism 126699720 Common - putative ABC transporter, permease protein CD2103 21 COG0392 COG0392, Predicted integral membrane protein Function unknown 126701012 Common - conjugative transposon protein CD3390 6 None None None 126697880 Common - hypothetical protein CD0308 2 None None None 126698614 Common - putative glycosyl transferase CD1030 201 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 126697930 Common - putative transcriptional regulator CD0360 10 COG1725 COG1725, Predicted transcriptional regulators Transcription 126698006 Common - putative sigma factor CD0435 4 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 126701142 Common murC UDP-N-acetylmuramate--L-alanine ligase CD3518 210 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 126700934 Common hydN2 electron transport protein CD3315 153 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 126698126 Common - putative penicillin-binding protein repressor CD0547 34 COG3682 COG3682, Predicted transcriptional regulator Transcription 126699605 Common - ArsR-family transcriptional regulator CD1994A 85 COG0640 ArsR, Predicted transcriptional regulators Transcription 126698800 Common xseB exodeoxyribonuclease VII small subunit CD1204 58 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 126700118 Common - putative histidinol-phosphate aminotransferase CD2502 239 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 126699548 Common accB biotin carboxyl carrier protein of acetyl-CoA carboxylase CD1939 181 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 126697638 Common tufB elongation factor Tu CD0071 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 126699097 Common - putative 3-methyladenine DNA glycosylase CD1493 80 COG2094 Mpg, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 126700931 Common - probable transporter CD3312 83 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 126697631 Common rplL 50S ribosomal protein L7/L12 CD0064 214 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 126698033 Pathogen - hypothetical protein CD0457 1 None None None 126701149 Common - putative iron ABC transporter, solute-binding protein CD3525 113 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 126699486 Common vexP2 ABC transporter, ATP-binding protein CD1874 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126701121 Common - bifunctional protein CD3497 157 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 126698199 Common - hypothetical protein CD0622 7 None None None 126698626 Common sbcD nuclease subunit D CD1042 115 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 126698619 Common - cell surface protein (putative N-acetylmuramoyl-L-alanine amidase) CD1035 168 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 126700641 Pathogen - hypothetical protein CD3023 1 None None None 126699054 Common folP dihydropteroate synthase CD1450 218 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 126700944 Common - hypothetical protein CD3325 13 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 126700663 Common - putative acyl-CoA reductase/dehydratase CD3045 62 COG2971 COG2971, Predicted N-acetylglucosamine kinase Carbohydrate transport and metabolism 126699242 Common - hypothetical protein CD1638 4 None None None 126700545 Common - putative phage DNA-binding protein CD2927 52 COG2856 COG2856, Predicted Zn peptidase Amino acid transport and metabolism 126697929 Common - conjugative transposon conserved hypothetical protein CD0359 7 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 126700670 Common - two-component system sensor histidine kinase CD3053 205 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126700417 Common - putative protein translocase subunit CD2801 175 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 126697761 Common - putative ketopantoate reductase CD0188 106 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 126701056 Common cbiB cobalamin biosynthesis protein CD3433 149 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 126698973 Common - phage protein CD1372 4 None None None 126699575 Common - putative acyl-CoA thioesterase CD1966 18 COG1647 COG1647, Esterase/lipase General function prediction only 126699674 Common - hypothetical protein CD2057 5 None None None 126698571 Common - putative hydrolase CD0987 62 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 126700434 Common - ABC transporter, ATP-binding/permease protein CD2818 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 126697643 Common rplB 50S ribosomal protein L2 CD0076 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 126697976 Pathogen - hypothetical protein CD0408 1 None None None 126699499 Common - hypothetical protein CD1888 1 None None None 126700219 Common - putative general stress protein CD2599 52 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 126699757 Common rpsB 30S ribosomal protein S2 CD2140 247 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 126698528 Common - putative phage scaffold protein CD0947 1 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 126698116 Common - putative chemosensory protein CD0537 208 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 126699994 Common - butyrate kinase CD2379 101 COG3426 COG3426, Butyrate kinase Energy production and conversion 126700648 Common malX PTS system, maltose and glucose-specific IIbc component CD3030 51 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 126699447 Common aroK shikimate kinase CD1838 200 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 126697738 Common - putative amidohydrolase/peptidase CD0166 172 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 126698807 Common - putative acetyltransferase CD1211 21 COG0456 RimI, Acetyltransferases General function prediction only 126700712 Common bglA1 6-phospho-beta-glucosidase CD3095 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 126699596 Common trpP putative tryptophan transport protein CD1988 6 None None None 126700077 Common dnaJ chaperone protein CD2460 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 126701030 Common hymC putative iron-only hydrogenase, catalytic subunit CD3407 182 COG4624 COG4624, Iron only hydrogenase large subunit, C-terminal domain General function prediction only 126699521 Common - two-component sensor histidine kinase CD1911 97 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 126700351 Common - LysR-family transcriptional regulator CD2736 191 COG0583 LysR, Transcriptional regulator Transcription 126701017 Common pykF pyruvate kinase CD3394 234 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 126697835 Common flhA flagellar biosynthesis protein A CD0263 127 COG1298 FlhA, Flagellar biosynthesis pathway, component FlhA Cell motility and secretion / Intracellular trafficking and secretion 126701176 Common - hypothetical protein CD3551A 22 COG2155 COG2155, Uncharacterized conserved protein Function unknown 126699736 Common thrB homoserine kinase CD2119 123 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 126698228 Common - putative peptidase CD0650 107 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 126697672 Common - ABC transporter, ATP-binding protein CD0101 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 126700385 Common - capsular polysaccharide biosynthesis protein CD2769 166 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 126697879 Common - putative 'four-disulfide core' protein CD0307 1 None None None 126698004 Common - ABC transporter, ATP-binding/permease protein CD0433 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 126700086 Common spoIIP putative stage II sporulation protein P CD2469 15 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 126699304 Common ribA riboflavin biosynthesis protein CD1698 232 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 126701219 Common pyrF orotidine 5'-phosphate decarboxylase CD3592 164 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 126698426 Pathogen - hypothetical protein CD0846 1 None None None 126698336 Common - putative reductase CD0756 82 COG0778 NfnB, Nitroreductase Energy production and conversion 126698472 Common - metallo-beta-lactamase superfamily exported protein CD0895 98 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 126699002 Common - hypothetical protein CD1400 1 None None None 126698671 Common - ABC transporter, ATP-binding/permease protein CD1084 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 126697908 Common - ABC transporter, ATP-binding protein CD0336 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126699140 Common - ferredoxin--NADP(+) reductase subunit alpha CD1536 94 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 126697902 Common - hypothetical protein CD0330 18 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 126699824 Common - putative flavodoxin CD2207 7 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 126698055 Common spaF putative lantibiotic ABC transporter,ATP-binding protein CD0478 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126698938 Common - aspartate aminotransferase CD1339 240 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 126697747 Common - putative oxidoreductase, acetyl-CoA synthase subunit CD0174 26 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 126697583 Common - hypothetical protein CD0017 190 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 126700767 Common - hypothetical protein CD3150 25 None None None 126700548 Common - putative phage anti-repressor protein CD2930 16 COG3561 COG3561, Phage anti-repressor protein Transcription 126700504 Common - ABC transporter, permease protein CD2888 197 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 126697852 Common - hypothetical protein CD0279A 3 None None None 126698326 Pathogen - hypothetical protein CD0746 1 None None None 126698511 Pathogen - hypothetical protein CD0933 1 None None None 126699009 Common - hypothetical protein CD1406 12 None None None 126699182 Common - putative two-component histidine kinase CD1579 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126700431 Pathogen - hypothetical protein CD2815 1 None None None 126698445 Common - hypothetical protein CD0868 70 COG1910 COG1910, Periplasmic molybdate-binding protein/domain Inorganic ion transport and metabolism 126699952 Common mtlA PTS system, mannitol-specific IIbc component CD2334 41 COG2213 MtlA, Phosphotransferase system, mannitol-specific IIBC component Carbohydrate transport and metabolism 126699832 Common - putative regulatory protein CD2215 21 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 126699402 Common - hypothetical protein CD1793 1 None None None 126700573 Common ntpD V-type ATP synthase subunit D CD2954 44 COG1394 NtpD, Archaeal/vacuolar-type H+-ATPase subunit D Energy production and conversion 126699103 Common - putative membrane protein (virulence factor (MviN) homologue) CD1499 180 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 126700373 Common - putative phospholipase CD2757 56 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 126698406 Common - putative oxidative stress regulatory protein CD0826 170 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 126697689 Common - putative subunit of oxidoreductase CD0117 106 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 126698363 Common - putative stage IV sporulation protein CD0783 15 None None None 126700181 Common rpmB 50S ribosomal protein L28 CD2562A 65 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 126698479 Common - putative cation efflux rotein CD0902 196 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 126700194 Common - ribulose-phosphate 3-epimerase CD2575 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 126700864 Common prdR sigma-54-dependent transcriptional activator CD3245 195 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 126699770 Common - putative ATP/GTP-binding protein CD2154 223 COG1160 COG1160, Predicted GTPases General function prediction only 126700813 Common - AraC-family transcriptional regulator CD3194 139 COG3449 COG3449, DNA gyrase inhibitor DNA replication, recombination, and repair 126698503 Pathogen - hypothetical protein CD0926 1 None None None 126698568 Common - hypothetical protein CD0984 18 COG2426 COG2426, Predicted membrane protein Function unknown 126700444 Common - aspartate aminotransferase CD2828 240 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 126700469 Common dltA D-alanine--poly(phosphoribitol) ligase subunit 1 (D-alanine-activating enzyme) CD2853 202 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 126700527 Common - phage protein CD2909 5 None None None 126698712 Common dhaB1 glycerol dehydratase CD1120 59 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 126698192 Pathogen - hypothetical protein CD0614 1 None None None 126699808 Common - hypothetical protein CD2192 1 None None None 126698955 Common - putative regulatory protein CD1356 10 COG0517 COG0517, FOG: CBS domain General function prediction only 126701305 Common oxaA1 putative sporulation membrane protein CD3678 214 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 126700889 Common - putative cation transporter CD3270 119 COG1285 SapB, Uncharacterized membrane protein Function unknown 126697758 Common pyrK dihydroorotate dehydrogenase electron transfer subunit CD0185 86 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 126699879 Common - probable proton-dependent oligopeptide transporter CD2262 81 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 126698922 Common tepA translocation-enhancing protein TepA CD1323 82 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 126699274 Common - ABC transporter, ATP-binding protein CD1669 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126697607 Common - PTS system, IIa component CD0041 22 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 126701248 Common phnA putative phosphonoacetate hydrolase CD3622 82 COG2824 PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism Inorganic ion transport and metabolism 126699971 Common trxA2 thioredoxin CD2355 226 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 126700174 Common - bifunctional protein CD2556 39 COG3711 BglG, Transcriptional antiterminator Transcription 126698040 Common - putative hydrolase CD0464 135 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 126697958 Common bglA 6-phospho-beta-glucosidase CD0389 102 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 126701281 Common - DNA replication protein DnaC CD3654 15 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 126699717 Common - putative [2Fe-2S]-binding subunit of oxidoreductase CD2100 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 126698904 Common - hypothetical protein CD1306 175 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 126699165 Common - putative dehydrogenase accessory protein CD1561 119 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 126699945 Common gatA PTS system, galactitol-specific IIa component CD2327 36 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 126700102 Common - Xaa-Pro dipeptidase CD2485 248 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 126698495 Common - phage protein CD0918 3 None None None 126700892 Common feoA3 putative ferrous iron transport protein A CD3273 49 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 126701125 Common mfd transcription-repair coupling factor CD3501 241 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 126701294 Common - hypothetical protein CD3666 6 None None None 126699560 Common - putative acetyltransferase CD1951 89 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 126699891 Common - putative sodium:solute symporter CD2276 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 126698879 Common alaS alanyl-tRNA synthetase CD1282 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126697784 Common - putative spore coat protein CD0213 2 COG5577 COG5577, Spore coat protein Cell envelope biogenesis, outer membrane 126701288 Common - hypothetical protein CD3661 5 None None None 126697924 Common - hypothetical protein CD0354A 3 COG2510 COG2510, Predicted membrane protein Function unknown 126699651 Common argC N-acetyl-gamma-glutamyl-phosphate reductase CD2034 206 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 126698490 Pathogen - hypothetical protein CD0913 1 None None None 126701042 Common hemB delta-aminolevulinic acid dehydratase CD3419 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 126699289 Common - hypothetical protein CD1683 18 None None None 126698686 Common - hypothetical protein CD1099A 5 None None None 126700715 Common bglG1 transcription antiterminator CD3098 29 COG3711 BglG, Transcriptional antiterminator Transcription 126701093 Common atpA ATP synthase alpha chain CD3470 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 126699572 Common - hypothetical protein CD1963 24 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 126698754 Common - hypothetical protein CD1159 35 COG5011 COG5011, Uncharacterized protein conserved in bacteria Function unknown 126698982 Common - putative phage regulatory protein CD1379 12 None None None 126700773 Common - hypothetical protein CD3155 32 COG3177 COG3177, Uncharacterized conserved protein Function unknown 126698771 Common - hypothetical protein CD1176 26 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 126700097 Common - hypothetical protein CD2480 26 COG3584 COG3584, Uncharacterized protein conserved in bacteria Function unknown 126699249 Common - hypothetical protein CD1645 28 COG5505 COG5505, Predicted integral membrane protein Function unknown 126700277 Common - putative signaling protein CD2663 176 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 126698047 Common blaI penicillinase repressor CD0471 44 COG3682 COG3682, Predicted transcriptional regulator Transcription 126700919 Common engB probable GTP-binding protein CD3300 197 COG0218 COG0218, Predicted GTPase General function prediction only 126698068 Common - PTS system, IIa component CD0491 90 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 126698018 Common - putative pyridoxal-phosphate dependent enzyme CD0444 185 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 126700298 Common - putative iron-sulfur flavoprotein CD2684 38 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 126700169 Common - hypothetical protein CD2552 18 COG4821 COG4821, Uncharacterized protein containing SIS (Sugar ISomerase) phosphosugar binding domain General function prediction only 126699383 Common - amino acid ABC transporter, substrate-binding protein CD1774 169 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 126700585 Common - putative signaling protein CD2965 168 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 126698075 Pathogen - conjugative transposon hypothetical protein CD0498A 1 None None None 126699802 Common - putative phage-related hypothetical protein CD2186 1 None None None 126699935 Common - two-component sensor histidine kinase CD2317 219 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 126698063 Common - two-component response regulator CD0486 226 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126699629 Common hydD putative hydrolase CD2012 98 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 126699193 Common - putative ribose ABC transporter,substrate-binding lipoprotein CD1589 106 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 126700984 Common - ABC transporter, ATP-binding protein CD3364 249 COG4586 COG4586, ABC-type uncharacterized transport system, ATPase component General function prediction only 126698219 Pathogen - hypothetical protein CD0641 1 None None None 126700092 Common - putative competence membrane protein CD2475 137 COG0658 ComEC, Predicted membrane metal-binding protein General function prediction only 126700405 Common cwp66 cell surface protein CD2789 10 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126698161 Common - putative signaling protein CD0583 176 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126699089 Common - hypothetical protein CD1485 8 None None None 126700564 Pathogen - hypothetical protein CD2946 1 None None None 126698271 Common - hypothetical protein CD0692 11 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 126697663 Common - putative ribosomal protein CD0093 3 COG2163 RPL14A, Ribosomal protein L14E/L6E/L27E Translation, ribosomal structure and biogenesis 126700910 Pathogen - hypothetical protein CD3291 1 None None None 126698745 Common divIVB septum site-determining protein (cell division inhibitor) CD1150 166 COG2894 MinD, Septum formation inhibitor-activating ATPase Cell division and chromosome partitioning 126700403 Common cwp84 cell surface protein (putative cell surface-associated cysteine protease) CD2787 24 COG4870 COG4870, Cysteine protease Posttranslational modification, protein turnover, chaperones 126698345 Common srlE PTS system, glucitol/sorbitol-specific IIb component CD0765 22 COG3732 SrlE, Phosphotransferase system sorbitol-specific component IIBC Carbohydrate transport and metabolism 126699814 Common - putative subunit of oxidoreductase CD2198 109 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 126698238 Common tcdB toxin B CD0660 19 COG5263 COG5263, FOG: Glucan-binding domain (YG repeat) General function prediction only 126698483 Common - putative phage regulatory protein CD0907 26 COG1476 COG1476, Predicted transcriptional regulators Transcription 126700763 Common - putative transposase (partial) CD3146A 3 None None None 126699588 Common - ABC transporter, substrate-binding protein CD1979 103 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 126700337 Common - two-component response regulator CD2722 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126697704 Common - putative DNA-binding protein CD0132 143 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 126699587 Common - ABC transporter, ATP-binding protein CD1978 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 126699325 Common - putative hydantoinase CD1718 112 COG0145 HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 126700046 Common - IclR-family transcriptional regulator CD2430 114 COG1414 IclR, Transcriptional regulator Transcription 126698259 Common - hypothetical protein CD0680 7 COG5485 COG5485, Predicted ester cyclase General function prediction only 126699076 Common - ABC transporter, ATP-binding/permease protein CD1472 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 126698458 Common - hypothetical protein CD0881 221 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 126698100 Common - hypothetical protein CD0519 6 None None None 126698699 Common - hypothetical protein CD1107A 2 None None None 126698188 Common - two-component sensor histidine kinase CD0610 16 COG2972 COG2972, Predicted signal transduction protein with a C-terminal ATPase domain Signal transduction mechanisms 126699356 Common - putative 2-hydroxyacyl-CoA dehydratase CD1749 38 COG1775 HgdB, Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB Amino acid transport and metabolism 126699338 Pathogen - putative acetyltransferase CD1731 2 COG4552 Eis, Predicted acetyltransferase involved in intracellular survival and related acetyltransferases General function prediction only 126698559 Pathogen - hypothetical protein CD0975 1 None None None 126699664 Common - putative two-component response regulator CD2047 214 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126699636 Common - probable transporter CD2019 217 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 126697874 Common rbsC ribose ABC transporter, permease protein CD0302 112 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 126700485 Common - putative sigma-54 dependent regulatory protein CD2869 171 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 126699915 Pathogen - hypothetical protein CD2299A 1 None None None 126699659 Common - putative transcriptional regulator CD2042 20 COG1309 AcrR, Transcriptional regulator Transcription 126700839 Common - putative methyltransferase CD3220 105 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 126698097 Common - putative transcription antiterminator CD0516 161 COG3933 COG3933, Transcriptional antiterminator Transcription 126700466 Common - DeoR-family transcriptional regulator CD2850 115 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 126698214 Common - putative radical SAM superfamily protein CD0636 107 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 126700997 Pathogen - hypothetical protein CD3374A 1 None None None 126697653 Common rpsN 30S ribosomal protein S14 CD0084A 186 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 126698884 Common fur ferric uptake regulation protein CD1287 210 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 126698792 Common spoIIIAE stage III sporulation-related protein CD1196 15 None None None 126697725 Common hpdB 4-hydroxyphenylacetate decarboxylase, catalytic subunit CD0153 59 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 126700522 Common - phage membrane protein CD2905 29 COG5281 COG5281, Phage-related minor tail protein Function unknown 126697594 Common - putative DNA-binding protein CD0028 29 COG1623 COG1623, Predicted nucleic-acid-binding protein (contains the HHH domain) General function prediction only 126700819 Common - putative ABC transporter, permease protein CD3200 2 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 126699550 Common - hypothetical protein CD1941 2 None None None 126700335 Common - hypothetical protein CD2720 14 None None None 126701152 Common - putative iron ABC transporter, solute-binding lipoprotein CD3528 114 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 126697682 Common - hypothetical protein CD0111 17 COG4856 COG4856, Uncharacterized protein conserved in bacteria Function unknown 126699848 Common asrC anaerobic sulfite reductase subunit C CD2231 126 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 126700255 Common - hypothetical protein CD2641 14 COG1873 COG1873, Uncharacterized conserved protein Function unknown 126700242 Pathogen - hypothetical protein CD2628 1 COG4547 CobT, Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) Coenzyme metabolism 126701006 Common - conjugative transposon protein CD3385 15 COG4734 ArdA, Antirestriction protein General function prediction only 126698285 Common - putative reductase CD0706 29 COG0778 NfnB, Nitroreductase Energy production and conversion 126697825 Common flgD putative basal-body rod modification protein CD0254 72 COG1843 FlgD, Flagellar hook capping protein Cell motility and secretion 126698267 Common - hypothetical protein CD0688 6 None None None 126699846 Common - hypothetical protein CD2229 29 COG1289 COG1289, Predicted membrane protein Function unknown 126699927 Pathogen - hypothetical protein CD2309 1 None None None 126701187 Common - hypothetical protein CD3561 2 COG4506 COG4506, Uncharacterized protein conserved in bacteria Function unknown 126699208 Common - ABC transporter, ATP-binding protein CD1604 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126698480 Common - phage integrase CD0904 79 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 126701220 Common - hypothetical protein CD3593 16 COG4887 COG4887, Uncharacterized metal-binding protein conserved in archaea General function prediction only 126698022 Common - putative amino acid racemase CD0448 19 COG3457 COG3457, Predicted amino acid racemase Amino acid transport and metabolism 126698607 Common - putative transcriptional regulator CD1023 113 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 126698987 Common - hypothetical protein CD1384 100 COG1540 COG1540, Uncharacterized proteins, homologs of lactam utilization protein B General function prediction only 126698186 Common - hypothetical protein CD0608 51 COG3665 COG3665, Uncharacterized conserved protein Function unknown 126700279 Common - AraC-family transcriptional regulator CD2665 59 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 126698681 Common - putative lantibiotic ABC transporter, permease protein CD1095 3 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 126697964 Common hadA isocaprenoyl-CoA:2-hydroxyisocaproate CoA-transferase CD0395 115 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 126698900 Common - putative pyrophosphohydrolase CD1302 10 None None None 126698338 Common plfA pyruvate formate-lyase activating enzyme CD0758 92 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 126700133 Common - putative regulatory protein CD2517 12 COG3682 COG3682, Predicted transcriptional regulator Transcription 126700552 Pathogen - hypothetical protein CD2934 1 None None None 126700166 Common - putative sugar transporter, permease protein CD2549 163 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 126699666 Common - hypothetical protein CD2049 35 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 126700742 Common ascB2 6-phospho-beta-glucosidase CD3124 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 126699138 Common - putative gamma-glutamyltranspeptidase CD1534 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 126700554 Common - hypothetical protein CD2936 8 None None None 126699905 Common - putative regulatory protein CD2290 11 COG3682 COG3682, Predicted transcriptional regulator Transcription 126699841 Pathogen - putative conjugative transposon protein CD2224 6 None None None 126699085 Common - hypothetical protein CD1481 21 COG2013 COG2013, Uncharacterized conserved protein Function unknown 126698487 Pathogen - hypothetical protein CD0910 1 None None None 126698564 Common - putative phage regulatory protein CD0979 8 COG3682 COG3682, Predicted transcriptional regulator Transcription 126699428 Common ade adenine deaminase CD1820 84 COG1001 AdeC, Adenine deaminase Nucleotide transport and metabolism 126698594 Common nagA N-acetylglucosamine-6-phosphate deacetylase CD1010 128 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 126699322 Common - putative molybdenum cofactor sulfurase CD1715 38 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 126700057 Common - PhoH-like protein CD2441a 199 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 126700568 Common - putative phage repressor CD2949 1 None None None 126698531 Pathogen - hypothetical protein CD0950 1 None None None 126700950 Pathogen - hypothetical protein CD3331 2 None None None 126699392 Common - two-component sensor histidine kinase CD1783 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126698636 Pathogen - hypothetical protein CD1052 1 None None None 126700301 Pathogen - hypothetical protein CD2687 1 None None None 126700018 Common dut deoxyuridine 5'-triphosphate nucleotidohydrolase CD2403 177 COG0756 Dut, dUTPase Nucleotide transport and metabolism 126697999 Common - AraC-family transcriptional regulator CD0428 77 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 126700850 Pathogen bclA2 exosporium glycoprotein CD3230 1 None None None 126698516 Common - putative phage anti-repressor CD0937 20 COG3561 COG3561, Phage anti-repressor protein Transcription 126698816 Common nudF ADP-ribose pyrophosphatase CD1220 167 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 126700011 Common - hypothetical protein CD2396 13 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 126699950 Common mtlF PTS system, mannitol-specific IIa component CD2332 88 COG4668 MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain Carbohydrate transport and metabolism 126700977 Common - putative protease CD3357 96 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 126698661 Common - PTS system, IIa component CD1074 28 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 126698935 Common malX PTS system, maltose and glucose-specific IIbc component CD1336 57 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 126699109 Common - putative drug/sodium antiporters CD1506 140 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 126699456 Common - putative conjugative transposon protein CD1847 15 None None None 126699071 Common - ABC transporter, permease protein CD1467 15 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126698692 Common - hypothetical protein CD1104 5 None None None 126699982 Common - putative permease CD2367 111 COG0701 COG0701, Predicted permeases General function prediction only 126701111 Common rho transcription termination factor Rho CD3487 210 COG1158 Rho, Transcription termination factor Transcription 126698435 Common oppA oligopeptide ABC transporter, substrate-binding lipoprotein CD0855 212 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 126700157 Common nox coenzyme A disulfide reductase CD2540 248 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 126700347 Common - putative sigma-54-interacting regulatory protein CD2732 169 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 126699329 Common - probable acyltransferase CD1723 86 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 126700362 Common ubiB probable ubiquinone biosynthesis protein CD2747 186 COG0661 AarF, Predicted unusual protein kinase General function prediction only 126698094 Pathogen - hypothetical protein CD0513 1 None None None 126699995 Common iorB indolepyruvate oxidoreductase subunit B CD2380 68 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 126701063 Common - putative aldose epimerase CD3440 43 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 126698438 Common - PTS system, IIb component CD0861 25 COG1440 CelA, Phosphotransferase system cellobiose-specific component IIB Carbohydrate transport and metabolism 126697912 Common - hypothetical protein CD0340 10 None None None 126698578 Common - putative aminotransferase CD0994 174 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 126700733 Common bglF PTS system, beta-glucoside-specific IIabc component CD3116 59 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 126698418 Pathogen - putative DNA-binding protein CD0838 2 COG2512 COG2512, Uncharacterized membrane-associated protein/domain Function unknown 126699620 Pathogen - conserved plasmid hypothetical protein CD2006A 1 None None None 126697774 Common - putative DNA repair protein CD0203 239 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 126700203 Common fmt methionyl-tRNA formyltransferase CD2584 220 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 126697931 Common - two-component system, sensor histidine kinase CD0361 208 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126699276 Common - two-component response regulator CD1671 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126699680 Common - hypothetical protein CD2063 1 None None None 126697716 Common prfB peptide chain release factor 2 CD0144 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 126700153 Common - two-component response regulator CD2536 218 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126698431 Common - hypothetical protein CD0851 4 None None None 126700875 Common valS valyl-tRNA synthetase CD3256 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126701159 Common phnJ putative phosphonate metabolism protein CD3535 45 COG3627 PhnJ, Uncharacterized enzyme of phosphonate metabolism Inorganic ion transport and metabolism 126700269 Common murF UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alan ine ligase CD2655 212 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 126698265 Common rpmI 50S ribosomal protein L35 CD0686 28 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 126698591 Common - hypothetical protein CD1007 11 None None None 126699689 Common - putative transposase CD2072 24 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 126701250 Common - putative ABC transporter, permease protein CD3624 8 COG4652 COG4652, Uncharacterized protein conserved in bacteria Function unknown 126700722 Common - alcohol dehydrogenase CD3105 169 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 126699133 Common - putative ABC transporter, permease protein CD1529 30 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 126698702 Common - putative conjugal transfer protein CD1110 29 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 126700709 Common - putative amino acid permease CD3092 183 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 126701285 Common rplI 50S ribosomal protein L9 CD3658 215 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 126699859 Common - hypothetical protein CD2242 4 None None None 126701047 Common cbiH cobalt-precorrin-3b c(17)-methyltransferase CD3424 127 COG1010 CobJ, Precorrin-3B methylase Coenzyme metabolism 126698658 Common - hypothetical protein CD1071 13 COG4224 COG4224, Uncharacterized protein conserved in bacteria Function unknown 126698880 Common - hypothetical protein CD1283 24 COG4472 COG4472, Uncharacterized protein conserved in bacteria Function unknown 126699292 Pathogen - putative DNA-binding protein CD1686 2 COG0856 COG0856, Orotate phosphoribosyltransferase homologs Nucleotide transport and metabolism 126701107 Common prfA peptide chain release factor 1 CD3484 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 126700781 Common - ABC transporter, ATP-binding protein CD3162 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126701231 Common - hypothetical protein CD3604 21 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 126698789 Common spoIIIAB stage III sporulation protein AB CD1193 4 None None None 126697665 Common rpmJ 50S ribosomal protein L36 CD0094A 137 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 126700941 Pathogen - hypothetical protein CD3322 1 None None None 126697992 Common - putative DNA topoisomerase CD0421 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 126701025 Common murB UDP-N-acetylenolpyruvoylglucosamine reductase CD3402 208 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 126698464 Common - GntR-family transcriptional regulator CD0887 128 COG1802 GntR, Transcriptional regulators Transcription 126700261 Common sbp hypothetical protein CD2647 25 COG3856 Sbp, Uncharacterized conserved protein (small basic protein) Function unknown 126700272 Common mraW S-adenosyl-methyltransferase CD2658 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 126698781 Common - putative signaling protein CD1185 182 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126699908 Pathogen - hypothetical protein CD2293 1 None None None 126698011 Common - hypothetical protein CD0438 3 None None None 126700422 Common ruvA holliday junction DNA helicase CD2806 210 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 126701256 Common - putative PTS system, IIb component CD3630 18 COG3414 SgaB, Phosphotransferase system, galactitol-specific IIB component Carbohydrate transport and metabolism 126698648 Pathogen - hypothetical protein CD1063A 1 None None None 126701019 Common dnaE DNA polymerase III DnaE CD3396 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 126699830 Common - putative carbonic anhydrase CD2213 40 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 126699129 Common - putative iron-sulfur protein CD1525 49 COG2006 COG2006, Uncharacterized conserved protein Function unknown 126697833 Common fliQ flagellar export protein CD0261 107 COG1987 FliQ, Flagellar biosynthesis pathway, component FliQ Cell motility and secretion / Intracellular trafficking and secretion 126699559 Common - hypothetical protein CD1950 59 COG1284 COG1284, Uncharacterized conserved protein Function unknown 126698132 Common - putative methylase CD0553 206 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 126698824 Common - putative protease CD1228 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 126699820 Common - TetR-family transcriptional regulator CD2203 44 COG1309 AcrR, Transcriptional regulator Transcription 126700972 Common - AraC-family transcriptional regulator CD3352 125 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 126698622 Common - putative helicase CD1038 225 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 126698861 Pathogen - hypothetical protein CD1264 1 None None None 126699709 Common - putative sigma-54-dependent transcriptional regulator CD2092 170 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 126698887 Pathogen - putative small acid-soluble spore protein CD1290 1 None None None 126697859 Common - PTS system, IIb component CD0287 41 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 126701070 Common - putative transcription antiterminator CD3447 30 COG3711 BglG, Transcriptional antiterminator Transcription 126699201 Common - hypothetical protein CD1597 2 None None None 126698241 Common dtxA hypothetical protein CD0664 4 COG4499 COG4499, Predicted membrane protein Function unknown 126701085 Common - CopG-family transcriptional regulator CD3462 14 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 126700025 Common ppdK pyruvate phosphate dikinase CD2410 235 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 126698453 Common - ABC transporter, substrate-binding lipoprotein CD0876 59 COG2984 COG2984, ABC-type uncharacterized transport system, periplasmic component General function prediction only 126700605 Common - ABC transporter, permease protein CD2984 17 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126699369 Common - putative iron-sulfur protein CD1760 10 COG1145 NapF, Ferredoxin Energy production and conversion 126699661 Pathogen - hypothetical protein CD2044 1 None None None 126700343 Common - hypothetical protein CD2728 19 COG3610 COG3610, Uncharacterized conserved protein Function unknown 126697690 Common - putative subunit of oxidoreductase CD0118 80 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 126700325 Common - LysR-family transcriptional regulator CD2711 191 COG0583 LysR, Transcriptional regulator Transcription 126699810 Common - putative regulator of a specific sugar metabolism CD2194 157 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 126699515 Common - site-specific recombinases CD1905 137 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 126699378 Common - hypothetical protein CD1769 66 COG3581 COG3581, Uncharacterized protein conserved in bacteria Function unknown 126699544 Common spoVS stage V sporulation protein S CD1935 24 COG2359 SpoVS, Uncharacterized protein conserved in bacteria Function unknown 126700615 Common nrdF ribonucleoside-diphosphate reductase beta chain CD2994 156 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 126699438 Common kdpE two-component response regulator CD1830 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126700281 Common ptsG PTS system, glucose-specific IIbc component CD2667 51 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 126697804 Common - hypothetical protein CD0233 38 COG1699 COG1699, Uncharacterized protein conserved in bacteria Function unknown 126701161 Common phnH putative phosphonate metabolism protein CD3537 18 COG3625 PhnH, Uncharacterized enzyme of phosphonate metabolism Inorganic ion transport and metabolism 126698087 Common orf6 conjugative transposon protein CD0508A 2 None None None 126699474 Pathogen - putative conjugative transposon conserved hypothetical protein CD1863 2 None None None 126699922 Pathogen - putative pilin protein CD2305 1 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 126697575 Common rsbV anti-sigma-B factor antagonist CD0009 61 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 126698202 Common - putative phage-related regulatory protein CD0625 7 None None None 126700043 Common - putative oxidoreductase subunit CD2428 108 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 126700859 Common - hypothetical protein CD3239 2 None None None 126699483 Pathogen - hypothetical protein CD1871A 2 None None None 126700035 Common - hypothetical protein CD2420 15 COG4927 COG4927, Predicted choloylglycine hydrolase General function prediction only 126699311 Common thiG thiazole synthase CD1704 166 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 126699829 Common - MarR-family transcriptional regulator CD2212 62 COG1846 MarR, Transcriptional regulators Transcription 126700233 Common - cell-division initiation protein CD2619 38 COG3599 DivIVA, Cell division initiation protein Cell division and chromosome partitioning 126700461 Common rbr rubrerythrin CD2845 76 COG1592 COG1592, Rubrerythrin Energy production and conversion 126701194 Common Veg hypothetical protein CD3568 18 COG4466 Veg, Uncharacterized protein conserved in bacteria Function unknown 126699250 Common - putative dipeptidase CD1646 104 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 126699860 Pathogen - hypothetical protein CD2243 1 None None None 126701165 Common spmB spore maturation protein B CD3541 39 COG0700 SpmB, Uncharacterized membrane protein Function unknown 126698179 Common ogt1 methylated-DNA--protein-cysteine methyltransferase 1 CD0601 215 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 126699262 Common gcvPB glycine dehydrogenase subunit 2 CD1658 173 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 126698961 Pathogen - hypothetical protein CD1361 1 None None None 126699235 Common sodA superoxide dismutase (Mn) CD1631 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 126699229 Common vanS two-component sensor histidine kinase CD1625 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126699361 Common - putative ABC transporter, permease protein CD1754 4 None None None 126700529 Common - hypothetical protein CD2910A 1 None None None 126700248 Common - hypothetical protein CD2634 4 None None None 126698738 Common maf septum formation protein CD1143 199 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 126698233 Common - metallo-beta-lactamase superfamily protein CD0655 19 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 126700006 Pathogen - hypothetical protein CD2391 1 None None None 126699149 Common - hypothetical protein CD1545 8 None None None 126700238 Pathogen - hypothetical protein CD2624 1 None None None 126698943 Common - putative cell wall biosynthesis protein CD1344 21 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 126700186 Common - PTS system, IIb component CD2567 66 COG1445 FrwB, Phosphotransferase system fructose-specific component IIB Carbohydrate transport and metabolism 126699010 Common - GntR-family transcriptional regulator CD1407 201 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 126698538 Common - phage protein CD0956 6 None None None 126699885 Common fruK putative 1-phosphofructokinase CD2270 114 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 126697815 Common - putative CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase CD0244 15 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 126698722 Common polA DNA polymerase I CD1128 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 126698948 Common - putative lantibiotic ABC transporter,ATP-binding protein CD1349 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126700210 Common dapF diaminopimelate epimerase CD2590 203 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 126699733 Common bipA GTP-binding protein CD2116 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 126700451 Common abgT putative aminobenzoyl-glutamate transport protein CD2835 38 COG2978 AbgT, Putative p-aminobenzoyl-glutamate transporter Coenzyme metabolism 126699969 Common grdA glycine/sarcosine/betaine reductase complex protein A CD2352 7 None None None 126697692 Common glmS glucosamine--fructose-6-phosphate aminotransferase (isomerizing) CD0120 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 126697793 Common purN phosphoribosylglycinamide formyltransferase CD0222 223 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 126700538 Common - phage protein CD2920 11 COG2369 COG2369, Uncharacterized protein, homolog of phage Mu protein gp30 Function unknown 126698341 Common - putative ATP-dependent RNA helicase CD0761 241 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 126698731 Common rnfC electron transport complex protein CD1137 116 COG4656 RnfC, Predicted NADH:ubiquinone oxidoreductase, subunit RnfC Energy production and conversion 126699286 Common - putative FMN-binding exported protein CD1680 6 COG3976 COG3976, Uncharacterized protein conserved in bacteria Function unknown 126697988 Common - putative conjugal transfer protein CD0418 47 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 126698845 Common - radical SAM-superfamily protein CD1249 96 COG1243 ELP3, Histone acetyltransferase Transcription / Chromatin structure and dynamics 126699934 Common - two-component response regulator CD2316 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126700645 Common crr PTS system, glucose-specific IIa component CD3027 60 COG2190 NagE, Phosphotransferase system IIA components Carbohydrate transport and metabolism 126699380 Common - hypothetical protein CD1771 1 None None None 126698839 Pathogen - hypothetical protein CD1243 1 None None None 126697700 Common fabZ (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase CD0128 188 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 126700786 Common - putative phosphatidylethanolamine-binding regulatory protein CD3167 63 COG1881 COG1881, Phospholipid-binding protein General function prediction only 126701290 Common ssb single-strand binding protein CD3662 195 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 126697809 Common - hypothetical protein CD0238 1 None None None 126697618 Common cysS cysteinyl-tRNA synthetase CD0052 242 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126697982 Pathogen - hypothetical protein CD0412A 1 None None None 126700535 Common - putative phage major capsid protein CD2916 4 None None None 126698309 Common gcvH putative glycine cleavage system H protein CD0729 187 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 126698147 Common - putative outer membrane lipoprotein CD0569 103 COG1744 Med, Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein General function prediction only 126699461 Common - putative conjugative transposon membrane protein CD1852 3 None None None 126700170 Common ulaA ascorbate-specific PTS system enzyme IIC CD2553 36 COG3037 SgaT, Uncharacterized protein conserved in bacteria Function unknown 126698507 Common - phage protein CD0930 26 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 126697768 Common - hypothetical protein CD0195 64 COG1691 COG1691, NCAIR mutase (PurE)-related proteins General function prediction only 126700752 Common - PTS system, IIabc component CD3134 110 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 126699769 Common - hypothetical protein CD2153 14 None None None 126700226 Common - putative amino acid permease CD2612 152 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 126700626 Common - IclR-family transcriptional regulator CD3005 113 COG1414 IclR, Transcriptional regulator Transcription 126699964 Pathogen - hypothetical protein CD2346 1 None None None 126699026 Common - putative signaling protein CD1421 170 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 126700728 Common - hypothetical protein CD3111 5 None None None 126698951 Common - lantibiotic two-component sensor histidine kinase CD1352 217 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126700684 Common - PTS system, IIa component CD3067 67 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 126699066 Common - GntR-family transcriptional regulator CD1462 86 COG1725 COG1725, Predicted transcriptional regulators Transcription 126698668 Common moeA molybdopterin biosynthesis protein CD1081 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 126700322 Common ydiB shikimate 5-dehydrogenase CD2708 225 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 126700354 Common aspS putative aspartyl-tRNA synthetase CD2739 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126697885 Common - putative heavy-metal-transporting ATPase CD0313 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 126698877 Common - NifU-like protein CD1280 156 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 126700396 Common pgm2 putative phosphomannomutase/phosphoglycerate mutase CD2780 241 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 126698354 Common spoVAD stage V sporulation protein AD CD0774 15 None None None 126698918 Common - putative polysaccharide deacetylase CD1319 49 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 126698716 Pathogen - hypothetical protein CD1124 1 None None None 126699872 Common - putative amino acid recemase CD2254 85 COG1794 RacX, Aspartate racemase Cell envelope biogenesis, outer membrane 126698914 Pathogen - hypothetical protein CD1315A 1 None None None 126700122 Common - putative transporter CD2506 208 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 126699505 Pathogen - hypothetical protein CD1895 1 COG4980 GvpP, Gas vesicle protein General function prediction only 126698688 Common - putative mobilization protein CD1101 5 None None None 126698178 Pathogen - hypothetical protein CD0600 1 None None None 126700083 Common - putative poly(A) polymerase CD2466 214 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 126697752 Common gluD NAD-specific glutamate dehydrogenase CD0179 174 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 126698589 Common - NAD-dependent malic enzyme CD1005 199 COG0281 SfcA, Malic enzyme Energy production and conversion 126700288 Common appC oligopeptide ABC transporter, permease protein CD2674 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 126698174 Pathogen - hypothetical protein CD0596 1 None None None 126700807 Pathogen - hypothetical protein CD3188 1 None None None 126698639 Common etfB2 electron transfer flavoprotein beta-subunit CD1055 152 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 126699269 Common - putative transcriptional regulator CD1664 97 COG3837 COG3837, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 126701201 Pathogen - hypothetical protein CD3574 1 None None None 126697751 Common - putative ATP-binding protein CD0178 11 None None None 126698404 Common - putative lantibiotic ABC transporter, permease protein CD0824 7 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 126698710 Common - hypothetical protein CD1118 14 None None None 126699142 Common - putative signaling protein CD1538 168 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 126700419 Common - hypothetical protein CD2803 3 None None None 126701210 Common - MerR-family transcriptional regulator CD3583 41 COG0789 SoxR, Predicted transcriptional regulators Transcription 126701262 Pathogen - hypothetical protein CD3636 1 None None None 126700682 Common xylB xylulose kinase CD3065 180 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 126700473 Common - putative hydrolase CD2857 206 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 126701097 Common atpB ATP synthase A chain CD3474 189 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 126698252 Common - hypothetical protein CD0673 25 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 126699007 Common - hypothetical protein CD1404A 6 None None None 126700188 Common - alpha-mannosidase CD2569 51 COG0383 AMS1, Alpha-mannosidase Carbohydrate transport and metabolism 126699151 Common hisZ putative ATP phosphoribosyltransferase regulatory subunit CD1547 127 COG3705 HisZ, ATP phosphoribosyltransferase involved in histidine biosynthesis Amino acid transport and metabolism 126700099 Common - putative lipoprotein CD2482 15 COG5341 COG5341, Uncharacterized protein conserved in bacteria Function unknown 126697872 Common rbsB D-ribose ABC transporter, substrate-binding protein CD0300 112 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 126700506 Pathogen - hypothetical protein CD2890 1 None None None 126699184 Pathogen - hypothetical protein CD1581 1 None None None 126701303 Common trmE putative tRNA modification GTPase CD3676 228 COG0486 ThdF, Predicted GTPase General function prediction only 126700543 Common - hypothetical protein CD2925 6 None None None 126698324 Common - putative chemotaxis protein CD0744 117 COG1291 MotA, Flagellar motor component Cell motility and secretion 126700295 Common - putative Calcium-chelating exported protein CD2681 87 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 126698799 Common xseA exodeoxyribonuclease VII large subunit CD1203 205 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 126699116 Common panC putative pantoate--beta-alanine ligase CD1512 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 126697951 Pathogen - hypothetical protein CD0382 1 None None None 126700371 Common ptsI phosphoenolpyruvate-protein phosphotransferase CD2755 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 126700212 Common fbpA fibronectin-binding protein CD2592 92 COG1293 COG1293, Predicted RNA-binding protein homologous to eukaryotic snRNP Transcription 126700797 Common xdhA3 xanthine dehydrogenase, molybdenum binding and iron-sulfur binding subunits CD3177 123 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 126699759 Common - hypothetical protein CD2142 9 None None None 126697736 Pathogen - hypothetical protein CD0164 1 None None None 126701206 Common - hypothetical protein CD3579 2 None None None 126698505 Pathogen - hypothetical protein CD0928 1 None None None 126700679 Common glvR phosphosugar-binding transcriptional regulator CD3062 42 COG1737 RpiR, Transcriptional regulators Transcription 126700120 Common - putative D-alanyl-D-alanine carboxypeptidase CD2504 38 COG1876 VanY, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 126700494 Common fhuD putative ferrichrome ABC transporter,substrate-binding protein CD2878 74 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 126699409 Common - tellurium resistance protein CD1800 29 COG2310 TerZ, Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 Signal transduction mechanisms 126700359 Common relA putative GTP pyrophosphokinase CD2744 209 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 126700224 Common trpS tryptophanyl-tRNA synthetase CD2610 237 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126697605 Common acoL E3 component of acetoin dehydrogenase enzyme system (dihydrolipoyl dehydrogenase) CD0039 244 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 126697865 Common - ABC transporter, ATP-binding protein CD0293 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126700245 Common - hypothetical protein CD2631 170 COG0344 COG0344, Predicted membrane protein Function unknown 126700378 Common uppS undecaprenyl pyrophosphate synthetase CD2762 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 126700837 Pathogen - hypothetical protein CD3218 1 None None None 126698521 Common - phage protein CD0941 6 None None None 126698921 Common dapG aspartate kinase I CD1322 238 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 126699167 Pathogen - hypothetical protein CD1564 1 None None None 126698763 Common - hypothetical protein CD1168 15 COG3314 COG3314, Uncharacterized protein conserved in bacteria Function unknown 126699507 Common - hypothetical protein CD1897 2 None None None 126701246 Common - hypothetical protein CD3620 3 None None None 126698673 Common - putative peptidase CD1086 169 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 126698566 Common - phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase CD0982 59 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 126698768 Common - putative FAD/FMN-containing dehydrogenase CD1173 202 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 126700800 Common pbuX xanthine permease CD3180 127 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 126698314 Common - hypothetical protein CD0734 5 COG1532 COG1532, Predicted RNA-binding protein General function prediction only 126700880 Common phoT phosphate import ABC transporter, ATP-binding protein CD3261 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 126699095 Common metQ putative D-methionine ABC transporter,substrate-binding lipoprotein CD1491 100 COG1464 NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen Inorganic ion transport and metabolism 126699618 Pathogen - conserved hypothetical protein (partial) CD2005A 1 None None None 126700205 Common priA putative primosomal protein N' CD2586 213 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 126700398 Common - cell surface protein CD2782 10 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 126699019 Common - hypothetical protein CD1416 12 COG3238 COG3238, Uncharacterized protein conserved in bacteria Function unknown 126698902 Common acd putative mannosyl-glycoprotein endo-beta-N-acetylglucosamidase CD1304 26 COG4193 LytD, Beta- N-acetylglucosaminidase Carbohydrate transport and metabolism 126700116 Common argH argininosuccinate lyase CD2500 235 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 126700629 Common - putative pyridine-nucleotide-disulfide oxidoreductase CD3009 244 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 126697973 Common - hypothetical protein CD0404 10 None None None 126700665 Common - hypothetical protein CD3047 17 COG3589 COG3589, Uncharacterized conserved protein Function unknown 126701053 Common cbiC precorrin-8X methylmutase CD3430 119 COG2082 CobH, Precorrin isomerase Coenzyme metabolism 126698557 Pathogen - hypothetical protein CD0973 1 None None None 126699052 Pathogen - hypothetical protein CD1448 2 None None None 126699240 Common - tellurium resistance protein CD1636 29 COG2310 TerZ, Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 Signal transduction mechanisms 126699122 Common feoA2 putative ferrous ion transport protein CD1518 13 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 126701054 Common - putative cobalamin biosynthesis kinase CD3431 26 COG4542 PduX, Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase Secondary metabolites biosynthesis, transport, and catabolism 126697651 Common rplX 50S ribosomal protein L24 CD0083 213 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 126699301 Common - putative arsenical pump membrane protein CD1695 191 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 126699513 Common - putative lipoprotein signal peptidase CD1903 1 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 126701140 Common spoVG stage V sporulation protein G CD3516 24 COG2088 SpoVG, Uncharacterized protein, involved in the regulation of septum location Cell envelope biogenesis, outer membrane 126698031 Common - hypothetical protein CD0455 45 COG3973 COG3973, Superfamily I DNA and RNA helicases General function prediction only 126699565 Common - two-component sensor histidine kinase CD1956 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126700776 Common smpB SsrA-binding protein CD3157 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 126700069 Common - hypothetical protein CD2452 2 COG1688 COG1688, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 126698584 Common - ABC transporter, permease protein CD1000 147 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 126699577 Common - hypothetical protein CD1968 48 COG1811 COG1811, Uncharacterized membrane protein, possible Na+ channel or pump General function prediction only 126699050 Common pabB para-aminobenzoate synthase component I CD1446 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 126699755 Common pyrH uridylate kinase CD2138 237 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 126699523 Common eutB putative ethanolamine/propanediol ammonia-lyase heavy chain CD1913 55 COG4303 EutB, Ethanolamine ammonia-lyase, large subunit Amino acid transport and metabolism 126699898 Common - putative sigma-54 interacting transcription antiterminator CD2283 161 COG1221 PspF, Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain Transcription / Signal transduction mechanisms 126700617 Common - hypothetical protein CD2996 56 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 126700643 Common - putative iron-sulfur-binding protein CD3025 38 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 126698292 Common - putative adenosylcobamide-dependent radical SAM superfamily protein CD0713 109 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 126697998 Common - putative DNA-binding protein CD0427 42 COG1476 COG1476, Predicted transcriptional regulators Transcription 126698002 Common - ABC transporter, ATP-binding protein CD0431 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 126700401 Common - hypothetical protein CD2785 18 COG4299 COG4299, Uncharacterized protein conserved in bacteria Function unknown 126698016 Common - putative oxidoreductase CD0442 27 COG3804 COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase Function unknown 126700383 Common - cell surface protein CD2767 46 COG1649 COG1649, Uncharacterized protein conserved in bacteria Function unknown 126699594 Common - putative radical SAM protein CD1986 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 126699738 Common - hypothetical protein CD2121 19 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 126699451 Common - hypothetical protein CD1842 27 COG1434 COG1434, Uncharacterized conserved protein Function unknown 126699449 Common - putative signaling protein CD1840 171 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 126697674 Common truA1 tRNA pseudouridine synthase 1 CD0103 237 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 126700636 Common - putative transcriptional antiterminator CD3016 38 COG3711 BglG, Transcriptional antiterminator Transcription 126697877 Common abgB1 putative aminobenzoyl-glutamate utilization protein CD0305 77 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 126699979 Common - hypothetical protein CD2364 2 None None None 126698999 Common - hypothetical protein CD1397 94 COG1720 COG1720, Uncharacterized conserved protein Function unknown 126699466 Common - putative conjugative transposon cell wall hydrolase CD1857 110 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 126701174 Common - putative thymidylate kinase CD3550 43 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 126698276 Common - putative cation transport protein CD0697 143 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 126700068 Common - probable ATP-dependent helicase CD2451 83 COG1203 COG1203, Predicted helicases General function prediction only 126697623 Common sigH RNA polymerase factor sigma-70 CD0057 56 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 126698036 Common - ABC transporter, permease protein CD0460 63 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126700964 Common - conjugative transposon-related FtsK/SpoIII-relatd protein CD3344 82 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 126697581 Common - putative cytosine/adenosine deaminase CD0015 216 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 126698858 Common - putative ribonucleotide-diphosphate reductase CD1261 227 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 126697568 Common dnaN DNA polymerase III subunit beta CD0002 216 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 126699414 Common sacA putative sucrose-6-phosphate hydrolase CD1805 53 COG1621 SacC, Beta-fructosidases (levanase/invertase) Carbohydrate transport and metabolism 126699195 Common kdpA potassium-transporting ATPase subunit A CD1591 96 COG2060 KdpA, K+-transporting ATPase, A chain Inorganic ion transport and metabolism 126699048 Common - putative exported polysaccharide deacetylase CD1444 129 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 126701241 Common - MerR-family transcriptional regulator CD3615 63 COG0789 SoxR, Predicted transcriptional regulators Transcription 126699046 Common - hypothetical protein CD1442 28 COG4642 COG4642, Uncharacterized protein conserved in bacteria Function unknown 126700912 Common - hypothetical protein CD3293 5 COG4972 PilM, Tfp pilus assembly protein, ATPase PilM Cell motility and secretion / Intracellular trafficking and secretion 126698470 Common - iron-dependent hydrogenase CD0893 66 COG4624 COG4624, Iron only hydrogenase large subunit, C-terminal domain General function prediction only 126698990 Common - putative allophanate hydrolase subunit 2 CD1387 115 COG1984 DUR1, Allophanate hydrolase subunit 2 Amino acid transport and metabolism 126700936 Common fdhD formate dehydrogenase accessory protein CD3316 137 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 126698273 Common - TetR-family transcriptional regulator CD0694 2 COG1309 AcrR, Transcriptional regulator Transcription 126700845 Common dapA2 dihydrodipicolinate synthase CD3225 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 126700790 Common eno enolase CD3170 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 126698489 Pathogen - putative phage DNA-binding protein CD0912 1 None None None 126698365 Common - ABC transporter, ATP-binding protein CD0785 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 126698236 Common cdu1 putative regulatory protein CD0658 4 COG3682 COG3682, Predicted transcriptional regulator Transcription 126698163 Common - GntR-family transcriptional regulator CD0585 18 COG2186 FadR, Transcriptional regulators Transcription 126699645 Common racX probable amino acid racemase CD2028 47 COG1794 RacX, Aspartate racemase Cell envelope biogenesis, outer membrane 126698526 Common - putative phage minor head protein CD0946 11 COG2369 COG2369, Uncharacterized protein, homolog of phage Mu protein gp30 Function unknown 126700986 Common - hypothetical protein CD3366 2 COG5279 CYK3, Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain Cell division and chromosome partitioning 126700761 Common - putative transcriptional regulator CD3144 97 COG2378 COG2378, Predicted transcriptional regulator Transcription 126701061 Common cobU bifunctional adenosylcobalamin biosynthesis protein CD3438 129 COG2087 CobU, Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase Coenzyme metabolism 126701035 Common uvrB excinuclease ABC subunit B CD3412 234 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 126700990 Pathogen - hypothetical protein CD3369 1 None None None 126697936 Common - putative lantibiotic ABC transporter,ATP-binding protein CD0366 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126699796 Common - putative helicase CD2180 143 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 126698697 Pathogen - hypothetical protein CD1106A 2 None None None 126701279 Common - putative peptidase CD3652 105 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 126700961 Pathogen - putative phage membrane protein CD3342 1 None None None 126698099 Common - hypothetical protein CD0518 19 COG3610 COG3610, Uncharacterized conserved protein Function unknown 126698482 Common - putative phage DNA-binding protein CD0906 2 None None None 126700071 Pathogen - hypothetical protein CD2454 1 None None None 126698825 Common - putative penicillin-binding protein CD1229 208 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 126699336 Common - putative transcriptional regulator (partial) CD1729A 58 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 126699726 Common - putative sodium:sulfate symporter CD2109 32 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 126699073 Common - cell surface protein (putative penicillin-binding protein) CD1469 139 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 126701118 Common - hypothetical protein CD3494 13 None None None 126699676 Common glnS glutaminyl-tRNA synthetase CD2059 247 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 126700487 Common uxaA' altronate hydrolase (N-terminus) CD2871 62 COG2721 UxaA, Altronate dehydratase Carbohydrate transport and metabolism 126698628 Common - putative modulator of ions transport CD1044 218 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 126699348 Common grdF sarcosine reductase complex component b beta subunit CD1741 8 None None None 126697741 Common - putative drug/sodium antiporter CD0169 165 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 126697636 Common rpsG 30S ribosomal protein S7 CD0069 249 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 126700948 Pathogen - conjugative transposon conserved hypothetical protein CD3329 6 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 126698348 Common gutD sorbitol-6-phosphate dehydrogenase CD0768 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 126698794 Common spoIIIAG stage III sporulation protein AG CD1198 15 None None None 126698283 Common - putative phosphohydrolase CD0704 31 COG2316 COG2316, Predicted hydrolase (HD superfamily) General function prediction only 126699634 Common - putative phage regulatory protein CD2017 35 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 126698375 Common - hypothetical protein CD0795 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 126700515 Common - putative phage tail fiber protein CD2898 23 COG5301 COG5301, Phage-related tail fibre protein General function prediction only 126698394 Common - GntR-family transcriptional regulator CD0814 106 COG2186 FadR, Transcriptional regulators Transcription 126698889 Common - hypothetical protein CD1292 12 COG4954 COG4954, Uncharacterized protein conserved in bacteria Function unknown 126699610 Common fldX flavodoxin CD1999 15 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 126698790 Common spoIIIAC stage III sporulation protein AC CD1194 15 None None None 126701144 Common - putative cation efflux protein CD3520 211 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 126699440 Pathogen - hypothetical protein CD1831A 1 None None None 126701008 Pathogen - conjugative transposon hypothetical protein CD3387 2 None None None 126699553 Common - hypothetical protein CD1944 9 None None None 126699943 Common gatC PTS system, galactitol-specific IIc component CD2325 19 COG3775 GatC, Phosphotransferase system, galactitol-specific IIC component Carbohydrate transport and metabolism 126699562 Common - hypothetical protein CD1953 6 COG1478 COG1478, Uncharacterized conserved protein Function unknown 126701272 Common - PTS system, IIc component CD3645 38 COG1455 CelB, Phosphotransferase system cellobiose-specific component IIC Carbohydrate transport and metabolism 126700898 Common - PTS system, IIb component CD3279 41 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 126700146 Pathogen - hypothetical protein CD2529 1 None None None 126699715 Pathogen - hypothetical protein CD2098 1 None None None 126700870 Common - hypothetical protein CD3251 63 COG3391 COG3391, Uncharacterized conserved protein Function unknown 126698411 Common - putative ATP-dependent RNA helicase CD0831 239 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 126699977 Common - putative aliphatic sulfonate ABC transporter,ATP-binding protein CD2361 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 126697735 Pathogen - hypothetical protein CD0163B 1 None None None 126697942 Common - putative cell wall hydrolase CD0372 129 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 126699057 Common - chorismate biosynthesis-related protein CD1453 186 COG2876 AroA, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 126700738 Pathogen - hypothetical protein CD3120A 1 None None None 126700104 Common - PTS system, IIb component CD2487 65 COG1445 FrwB, Phosphotransferase system fructose-specific component IIB Carbohydrate transport and metabolism 126700442 Common - putative oxidoreductase (FAD-binding domain) CD2826 176 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 126698612 Common - putative signaling protein CD1028 26 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126699353 Common gltC sodium/glutamate symporter CD1746 52 COG0786 GltS, Na+/glutamate symporter Amino acid transport and metabolism 126698049 Common - MarR-family transcriptional regulator CD0473 90 COG1846 MarR, Transcriptional regulators Transcription 126699653 Common - putative peptidylarginine deiminase CD2036 22 COG2957 COG2957, Peptidylarginine deiminase and related enzymes Amino acid transport and metabolism 126697786 Common - transposase CD0215 73 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 126698931 Common bacA1 undecaprenyl-diphosphatase CD1332 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 126699350 Common - two-component sensor histidine kinase CD1744 16 COG3290 CitA, Signal transduction histidine kinase regulating citrate/malate metabolism Signal transduction mechanisms 126698493 Common - phage protein CD0916 10 None None None 126698975 Common - hypothetical protein CD1374 32 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 126701223 Common - putative homocysteine S-methyltransferase CD3596 180 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 126701095 Common atpF ATP synthase B chain CD3472 134 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 126698984 Common - TetR-family transcriptional regulator CD1381 32 COG1309 AcrR, Transcriptional regulator Transcription 126699772 Common thiH thiamine biosynthesis protein ThiH CD2156 56 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 126698024 Common - hypothetical protein CD0450 10 COG4978 COG4978, Transcriptional regulator, effector-binding domain/component Transcription / Signal transduction mechanisms 126699399 Common - putative exonuclease CD1790 5 COG5018 KapD, Inhibitor of the KinA pathway to sporulation, predicted exonuclease General function prediction only 126699224 Common - putative permease CD1620 162 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 126700717 Common - putative C4-dicarboxylate anaerobic carrier CD3100 42 COG1288 COG1288, Predicted membrane protein Function unknown 126699394 Common argG argininosuccinate synthase CD1785 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 126698402 Common - putative lantibiotic ABC transporter,ATP-binding protein CD0822 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126698451 Common - ABC transporter, ATP-binding protein CD0874 249 COG1101 PhnK, ABC-type uncharacterized transport system, ATPase component General function prediction only 126698477 Common opuCA glycine betaine/carnitine/choline ABC transporter, ATP-binding protein CD0900 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 126698077 Pathogen orf19 conjugative transposon protein CD0499A 5 None None None 126698747 Common mrdB rod shape-determining protein CD1152 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 126699694 Common pyrD dihydroorotate dehydrogenase, catalytic subunit CD2077 162 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 126700583 Common - putative peptidoglycan-binding exported protein CD2963 14 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 126698891 Common - putative membrane-associated peptidase CD1294 85 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 126701286 Common - putative RNA/single-stranded DNA exonuclease CD3659 77 COG3887 COG3887, Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain Signal transduction mechanisms 126700771 Common - putative phage DNA-binding protein CD3153 22 COG1476 COG1476, Predicted transcriptional regulators Transcription 126701044 Common hemC porphobilinogen deaminase CD3421 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 126698107 Common - putative amidohydrolase CD0528 107 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 126697748 Common - putative oxidoreductase, electron transfer subunit CD0175 155 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 126700651 Common - thioredoxin CD3033 235 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 126699623 Common - putative plasmid replication protein CD2008 199 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 126699012 Common - competence damage-inducible protein A CD1409 213 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 126698752 Common norV putative anaerobic nitric oxide reductase flavorubredoxin CD1157 85 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 126699385 Common - amino acid ABC transporter, ATP-binding protein CD1776 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 126700172 Common tlpA transposase-like protein A CD2554 2 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 126697906 Common adhE aldehyde-alcohol dehydrogenase [includes: alcohol dehydrogenase; acetaldehyde dehydrogenase [acetylating]; pyruvate-formate-lyase deactivase CD0334 210 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 126698433 Common oppB oligopeptide ABC transporter, permease protein CD0853 218 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 126699031 Common - putative transcriptional regulator CD1428 123 COG1733 COG1733, Predicted transcriptional regulators Transcription 126698443 Common - hypothetical protein CD0866 58 COG1073 COG1073, Hydrolases of the alpha/beta superfamily General function prediction only 126698244 Common cdd2 putative lantibiotic ABC transporter, permease protein CD0665 13 COG4200 COG4200, Uncharacterized protein conserved in bacteria Function unknown 126698634 Common - ABC transporter, ATP-binding protein CD1050 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126699000 Common - putative peptidase CD1398 168 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 126699100 Common - hypothetical protein CD1496 12 COG4086 COG4086, Predicted secreted protein Function unknown 126699710 Common - hypothetical protein CD2093 24 COG4268 McrC, McrBC 5-methylcytosine restriction system component Defense mechanisms 126701171 Common - hypothetical protein CD3547 69 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 126698061 Common - ABC transporter, ATP-binding protein CD0484 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126698124 Pathogen - putative lipoprotein CD0545 1 None None None 126701296 Common - putative transcriptional regulator CD3668 46 None None None 126699999 Common - putative signaling protein CD2384 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 126698066 Common - putative phosphoribosylaminoimidazole-succinocarboxamide synthase CD0489 147 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism