Actinobacillus pleuropneumoniae L20, complete genome NC_009053 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 126209495 Common - hypothetical protein APL_2041 52 COG2912 COG2912, Uncharacterized conserved protein Function unknown 126209006 Common xerD site-specific tyrosine recombinase XerD APL_1542 230 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 126208241 Common perM putative permease perM-like protein APL_0763 174 COG0628 PerM, Predicted permease General function prediction only 126207685 Pathogen - hypothetical protein APL_0197 1 None None None 126208208 Common ilvH acetolactate synthase 3 regulatory subunit APL_0728 191 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 126209464 Common hbpA Heme-binding protein A APL_2010 211 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 126209479 Common hisH imidazole glycerol phosphate synthase subunit HisH APL_2025 220 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 126208366 Common - hypothetical protein APL_0890 26 COG0679 COG0679, Predicted permeases General function prediction only 126208442 Common - hypothetical protein APL_0968 22 COG3112 COG3112, Uncharacterized protein conserved in bacteria Function unknown 126207881 Common lcfA long-chain-fatty-acid--CoA ligase APL_0397 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 126208489 Common deoC deoxyribose-phosphate aldolase APL_1015 136 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 126208944 Common - DNA-binding transcriptional repressor FabR APL_1480 54 COG1309 AcrR, Transcriptional regulator Transcription 126209283 Common rpmE2 50S ribosomal protein L31 type B APL_1821 80 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 126208654 Common - putative transcriptional regulator APL_1186 179 COG0583 LysR, Transcriptional regulator Transcription 126208474 Common mrp putative ATPase APL_1000 229 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 126208973 Common secB preprotein translocase subunit SecB APL_1509 107 COG1952 SecB, Preprotein translocase subunit SecB Intracellular trafficking and secretion 126208719 Common - putative sodium/sulphate transporter APL_1253 189 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 126208500 Common - putative glycosyltransferase APL_1026 75 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 126209081 Common ureB urease subunit beta APL_1617 96 COG0832 UreB, Urea amidohydrolase (urease) beta subunit Amino acid transport and metabolism 126208946 Common - hybrid peroxiredoxin HyPrx5 APL_1482 112 COG0678 AHP1, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 126209181 Common nusG transcription antitermination protein NusG APL_1717 214 COG0250 NusG, Transcription antiterminator Transcription 126207855 Common lnt apolipoprotein N-acyltransferase APL_0371 163 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 126207995 Common - hypothetical protein APL_0511 9 COG5471 COG5471, Uncharacterized conserved protein Function unknown 126208481 Common hemY HemY-like protein APL_1007 41 COG3071 HemY, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 126207753 Common dnaX DNA polymerase III subunits gamma and tau APL_0265 248 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 126209251 Common rimM 16S rRNA-processing protein APL_1787 173 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 126208993 Common frdA fumarate reductase flavoprotein subunit APL_1529 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 126208064 Common sotB sugar efflux transporter APL_0582 128 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 126208930 Pathogen - hypothetical protein APL_1466 1 None None None 126208430 Pathogen - hypothetical protein APL_0954 1 None None None 126207830 Common glgB glycogen branching enzyme APL_0346 150 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 126208793 Common hypE hydrogenase isoenzymes formation protein HypE APL_1329 145 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 126208891 Common napH quinol dehydrogenase membrane component APL_1427 89 COG0348 NapH, Polyferredoxin Energy production and conversion 126208909 Common apxIC RTX-I toxin-activating lysine-acyltransferase ApxIC APL_1445 16 COG2994 HlyC, ACP:hemolysin acyltransferase (hemolysin-activating protein) Posttranslational modification, protein turnover, chaperones 126208545 Common - hypothetical protein APL_1073 63 COG2128 COG2128, Uncharacterized conserved protein Function unknown 126208567 Common purM phosphoribosylaminoimidazole synthetase APL_1095 232 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 126208637 Common rplI 50S ribosomal protein L9 APL_1169 181 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 126209168 Common araD L-ribulose-5-phosphate 4-epimerase APL_1704 118 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 126208052 Common frr ribosome recycling factor APL_0570 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 126207729 Common mutT mutator mutT protein APL_0241 97 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 126208461 Common htpG heat shock protein 90 APL_0987 151 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 126208412 Common - hypothetical protein APL_0936 15 None None None 126207828 Common fruK 1-phosphofructokinase APL_0344 136 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 126208531 Common - hypothetical transposase-like protein APL_1059 138 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 126207591 Common nrfD nitrite reductase transmembrane protein APL_0103 30 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 126207964 Common - hypothetical protein APL_0480 98 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 126208035 Common tadZ flp operon protein D APL_0553 8 COG4963 CpaE, Flp pilus assembly protein, ATPase CpaE Intracellular trafficking and secretion 126207783 Common - hypothetical protein APL_0299 138 COG0824 FcbC, Predicted thioesterase General function prediction only 126208116 Common hsdS3 putative type I restriction system specificity protein APL_0634 69 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 126209200 Common hslV ATP-dependent protease peptidase subunit APL_1736 149 COG5405 HslV, ATP-dependent protease HslVU (ClpYQ), peptidase subunit Posttranslational modification, protein turnover, chaperones 126209312 Common birA Bifunctional protein birA APL_1850 182 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 126208024 Common lepB Signal peptidase I APL_0542 206 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 126207847 Common - hypothetical protein APL_0363 19 COG2990 VirK, Uncharacterized protein conserved in bacteria Function unknown 126207901 Common pgpB phosphatidylglycerophosphatase B APL_0417 19 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 126207630 Common glxK glycerate kinase APL_0142 81 COG1929 COG1929, Glycerate kinase Carbohydrate transport and metabolism 126207588 Common nrfA cytochrome c nitrite reductase APL_0100 40 COG3303 NrfA, Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit Inorganic ion transport and metabolism 126208307 Common - predicted membrane-bound metallopeptidase APL_0831 172 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 126208602 Common kdtA 3-deoxy-D-manno-octulosonic-acid transferase APL_1132 128 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 126208195 Common - ABC transport system permease protein APL_0715 191 COG4606 CeuB, ABC-type enterochelin transport system, permease component Inorganic ion transport and metabolism 126208889 Common napC cytochrome c-type protein NapC APL_1425 49 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 126208771 Common gnd 6-phosphogluconate dehydrogenase APL_1305 182 COG0362 Gnd, 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 126209427 Pathogen - hypothetical protein APL_1973 1 None None None 126208292 Common mltA murein transglycosylase A APL_0816 93 COG2821 MltA, Membrane-bound lytic murein transglycosylase Cell envelope biogenesis, outer membrane 126209071 Common - putative drug resistance protein APL_1607 135 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 126208928 Common wzm ABC transporter integral membrane subunit APL_1464 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 126207510 Common ftsA cell division protein FtsA APL_0022 183 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 126208468 Common galT galactose-1-phosphate uridylyltransferase APL_0994 78 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 126207716 Common - hypothetical protein APL_0228 219 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 126208352 Common coaE dephospho-CoA kinase APL_0876 207 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 126208386 Common plpA outer membrane lipoprotein 1 precursor APL_0910 100 COG1464 NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen Inorganic ion transport and metabolism 126208872 Common gshA bifunctional glutamate--cysteine ligase/glutathione synthetase APL_1408 97 COG2918 GshA, Gamma-glutamylcysteine synthetase Coenzyme metabolism 126209448 Common - hypothetical protein APL_1994 67 COG1636 COG1636, Uncharacterized protein conserved in bacteria Function unknown 126209037 Common - 2,3-diketo-L-gulonate reductase APL_1573 66 COG2055 COG2055, Malate/L-lactate dehydrogenases Energy production and conversion 126208875 Common - hypothetical protein APL_1411 15 COG3691 COG3691, Uncharacterized protein conserved in bacteria Function unknown 126207892 Common fabZ (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase APL_0408 187 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 126209452 Common - hypothetical protein APL_1998 21 COG2259 COG2259, Predicted membrane protein Function unknown 126208201 Common - hypothetical protein APL_0721 9 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 126207866 Common ribD riboflavin biosynthesis protein APL_0382 231 COG1985 RibD, Pyrimidine reductase, riboflavin biosynthesis Coenzyme metabolism 126207505 Common ftsW cell division protein FtsW APL_0017 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 126207551 Common dppA periplasmic dipeptide transport protein APL_0063 210 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 126208799 Common hyaD predicted maturation element for hydrogenase 2 APL_1335 78 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 126209209 Common - hypothetical protein APL_1745 38 COG3636 COG3636, Predicted transcriptional regulator Transcription 126209395 Common hemH Ferrochelatase APL_1937 169 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 126209019 Common hemL glutamate-1-semialdehyde 2,1-aminomutase APL_1555 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 126209485 Common - hypothetical protein APL_2031 3 None None None 126209156 Common - putative ABC transporter, permease protein, amino acid APL_1692 175 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 126207616 Common yfeC putative iron transport system membrane protein APL_0128 186 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 126207745 Common - probable outer membrane protein APL_0257 111 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 126207936 Common sucC succinyl-CoA synthetase beta chain APL_0452 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 126208801 Common hybG hydrogenase 2 accessory protein HypG APL_1337 74 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 126209226 Common rplW 50S ribosomal protein L23 APL_1762 134 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 126207706 Common - hypothetical protein APL_0218 18 None None None 126208587 Common - hypothetical protein APL_1115 6 COG4316 COG4316, Uncharacterized protein conserved in bacteria Function unknown 126207511 Common ftsZ cell division protein FtsZ APL_0023 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 126209024 Common rsmB ribosomal RNA small subunit methyltransferase B APL_1560 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 126209410 Common - hypothetical protein APL_1956 3 None None None 126208647 Common argH argininosuccinate lyase APL_1179 237 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 126207861 Common glpT glycerol-3-phosphate transporter APL_0377 82 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 126208765 Common - predicted TonB dependent/Ligand-Gated channel APL_1299 73 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 126208666 Common - putative NAD(P)H nitroreductase APL_1198 109 COG0778 NfnB, Nitroreductase Energy production and conversion 126209413 Common adhI alcohol dehydrogenase APL_1959 213 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 126207921 Common mreD rod shape-determining protein MreD APL_0437 60 COG2891 MreD, Cell shape-determining protein Cell envelope biogenesis, outer membrane 126207614 Common - HIT-like protein APL_0126 219 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 126208722 Common phoR phosphate regulon sensor protein PhoR APL_1256 222 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 126208621 Common - hypothetical protein APL_1151 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 126208955 Common - hypothetical protein APL_1491 48 COG2848 COG2848, Uncharacterized conserved protein Function unknown 126209206 Common srp54 signal recognition particle protein (sigma-54 like protein) APL_1742 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 126209281 Common acpP acyl carrier protein APL_1819 179 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 126207577 Common rhaT hypothetical protein APL_0089 173 COG2510 COG2510, Predicted membrane protein Function unknown 126208826 Common - hypothetical protein APL_1362 44 COG3107 LppC, Putative lipoprotein General function prediction only 126209136 Common rbsB D-ribose transporter subunit RbsB APL_1672 129 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 126207746 Common - hypothetical protein APL_0258 65 COG2914 COG2914, Uncharacterized protein conserved in bacteria Function unknown 126209232 Common rpmC 50S ribosomal protein L29 APL_1768 148 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 126209401 Common - ADP-ribose pyrophosphatase APL_1943 89 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 126207661 Common - hypothetical protein APL_0173 65 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 126208682 Common - hypothetical protein APL_1214 40 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 126209409 Common proA gamma-glutamyl phosphate reductase APL_1951 189 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 126208729 Common - hypothetical protein APL_1263 63 COG3019 COG3019, Predicted metal-binding protein General function prediction only 126209054 Common trkH Trk system potassium uptake protein TrkH APL_1590 142 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 126208293 Common xseA exodeoxyribonuclease VII large subunit APL_0817 205 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 126207555 Common dppD dipeptide transporter ATP-binding subunit APL_0067 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 126208288 Common res type III restriction enzyme APL_0812 44 COG3587 COG3587, Restriction endonuclease Defense mechanisms 126208291 Common - hypothetical protein APL_0815 6 None None None 126208486 Common groEL 60 kDa chaperonin APL_1012 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 126207519 Common - integral membrane protein APL_0031 10 COG3152 COG3152, Predicted membrane protein Function unknown 126209218 Common nanA N-acetylneuraminate lyase APL_1754 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 126207766 Common - putative Mg-dependent deoxyribonuclease APL_0278 170 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 126209123 Common - hypothetical protein APL_1659 2 None None None 126208186 Common - putative HTH-type transcriptional regulator APL_0706 127 COG1737 RpiR, Transcriptional regulators Transcription 126208264 Common - hypothetical protein APL_0786 5 None None None 126209486 Common scrR Sucrose operon repressor (Scr operon regulatory protein) APL_2032 123 COG1609 PurR, Transcriptional regulators Transcription 126207642 Common nqrE Na(+)-translocating NADH-quinone reductase subunit E APL_0154 76 COG2209 NqrE, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE Energy production and conversion 126207734 Common - truncated transferrin-binding protein 1 precursor APL_0246 89 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 126207620 Common - nucleotidase APL_0132 84 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 126208821 Common - putative HTH-type transcriptional regulator APL_1357 6 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 126208359 Common folA dihydrofolate reductase APL_0883 146 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 126209304 Common cysI Sulfite reductase [NADPH] hemoprotein beta-component (SIR-HP) (SIRHP) APL_1842 149 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 126208811 Common - putative methylase APL_1347 204 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 126208675 Common - hypothetical protein APL_1207 17 COG2161 StbD, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 126208083 Common rpsI 30S ribosomal protein S9 APL_0601 241 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 126208925 Common menA 1,4-dihydroxy-2-naphthoate octaprenyltransferase APL_1461 107 COG1575 MenA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase Coenzyme metabolism 126207694 Common suhB Inositol-1-monophosphatase (IMPase) APL_0206 210 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 126209093 Common mtlD mannitol-1-phosphate 5-dehydrogenase APL_1629 85 COG0246 MtlD, Mannitol-1-phosphate/altronate dehydrogenases Carbohydrate transport and metabolism 126209114 Common atpF F0F1 ATP synthase subunit B APL_1650 136 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 126209263 Common torC pentahemic c-type cytochrome APL_1799 23 None None None 126208003 Common - predicted phage minor tail protein APL_0519 7 COG4718 COG4718, Phage-related protein Function unknown 126209244 Common rpmJ 50S ribosomal protein L36 APL_1780 137 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 126209325 Common - predicted glycosyltransferase APL_1863 7 COG3774 OCH1, Mannosyltransferase OCH1 and related enzymes Cell envelope biogenesis, outer membrane 126207795 Common moeB molybdopterin biosynthesis protein MoeB APL_0311 224 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 126208721 Common parE DNA topoisomerase IV subunit B APL_1255 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 126209292 Common syp prolyl-tRNA synthetase APL_1830 249 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126207497 Common - hypothetical protein APL_0009 144 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 126208505 Common - hypothetical protein APL_1031 76 COG1434 COG1434, Uncharacterized conserved protein Function unknown 126207601 Common - hypothetical protein APL_0113 26 COG3068 COG3068, Uncharacterized protein conserved in bacteria Function unknown 126208800 Common hybE hydrogenase 2-specific chaperone APL_1336 18 None None None 126208690 Common - aspartate-semialdehyde dehydrogenase APL_1222 92 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 126208886 Common - hypothetical protein APL_1422 202 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 126209493 Common ldhA glycerate dehydrogenase APL_2039 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 126208375 Common dapA dihydrodipicolinate synthase APL_0899 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 126208226 Common aroC chorismate synthase APL_0748 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 126209057 Common lipA lipoyl synthase APL_1593 192 COG0320 LipA, Lipoate synthase Coenzyme metabolism 126208695 Common aphA AphA-like protein APL_1229 17 COG3726 AhpA, Uncharacterized membrane protein affecting hemolysin expression General function prediction only 126208788 Common crr glucose-specific PTS system component APL_1324 60 COG2190 NagE, Phosphotransferase system IIA components Carbohydrate transport and metabolism 126208968 Common - putative acetyltransferase APL_1504 95 COG2153 ElaA, Predicted acyltransferase General function prediction only 126208525 Common kefBC glutathione-regulated potassium-efflux system protein APL_1053 204 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 126207821 Common - hypothetical protein APL_0337 60 COG1934 COG1934, Uncharacterized protein conserved in bacteria Function unknown 126207972 Common - predicted phage integrase family protein APL_0488 18 None None None 126208426 Common - hypothetical protein APL_0950 25 COG2856 COG2856, Predicted Zn peptidase Amino acid transport and metabolism 126209088 Common cbiK putative periplasmic binding protein CbiK APL_1624 8 COG5266 CbiK, ABC-type Co2+ transport system, periplasmic component Inorganic ion transport and metabolism 126208213 Common - hypothetical protein APL_0733 47 COG1811 COG1811, Uncharacterized membrane protein, possible Na+ channel or pump General function prediction only 126208869 Common oapA opacity associated protein A APL_1405 4 COG3061 OapA, Cell envelope opacity-associated protein A Cell envelope biogenesis, outer membrane 126208170 Common moaA molybdenum cofactor biosynthesis protein A APL_0690 199 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 126207985 Common - possible DNA methylase APL_0501 7 None None None 126209412 Common mutL DNA mismatch repair protein APL_1958 191 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 126208582 Common - hypothetical protein APL_1110 101 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 126208210 Common - hypothetical protein APL_0730 61 COG3028 COG3028, Uncharacterized protein conserved in bacteria Function unknown 126208847 Common trmB tRNA (guanine-N(7))-methyltransferase APL_1383 179 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 126208453 Common lbgB putative D-glycero-D-manno-heptosyl transferase APL_0979 32 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 126208742 Common - antitoxin YefM APL_1276 54 COG2161 StbD, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 126208072 Common - hypothetical protein APL_0590 7 COG3955 COG3955, Exopolysaccharide biosynthesis protein Cell envelope biogenesis, outer membrane 126209197 Common - hypothetical protein APL_1733 14 COG4902 COG4902, Uncharacterized protein conserved in archaea Function unknown 126208396 Pathogen - hypothetical protein APL_0920 1 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 126209106 Common tusD hypothetical protein APL_1642 44 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 126207541 Common typA GTP-binding protein APL_0053 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 126209365 Common dnaJ Chaperone protein dnaJ APL_1905 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 126208134 Common alaS alanyl-tRNA synthetase APL_0654 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126209157 Common - putative amino-acid ABC transporter ATP-binding protein APL_1693 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 126209383 Common pgaC N-glycosyltransferase PgaC APL_1923 218 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 126208592 Common rluD 23S rRNA pseudouridine synthase D APL_1122 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 126208077 Common ftsH cell division protease FtsH-like protein APL_0595 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 126208958 Common ftpA fine tangled pili major subunit APL_1494 105 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 126209277 Pathogen - hypothetical protein APL_1815 4 COG3713 OmpV, Outer membrane protein V Cell envelope biogenesis, outer membrane 126208365 Common - hypothetical protein APL_0889 18 COG5339 COG5339, Uncharacterized protein conserved in bacteria Function unknown 126209494 Common kdsA 2-dehydro-3-deoxyphosphooctonate aldolase APL_2040 186 COG2877 KdsA, 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase Cell envelope biogenesis, outer membrane 126209344 Common recC Exodeoxyribonuclease V gamma chain APL_1884 69 COG1330 RecC, Exonuclease V gamma subunit DNA replication, recombination, and repair 126209473 Common hisG ATP phosphoribosyltransferase APL_2019 208 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 126208141 Common purK phosphoribosylaminoimidazole carboxylase ATPase subunit APL_0661 192 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 126207528 Common obgE GTPase ObgE APL_0040 249 COG0536 Obg, Predicted GTPase General function prediction only 126208306 Common - hypothetical protein APL_0830 62 COG2861 COG2861, Uncharacterized protein conserved in bacteria Function unknown 126208989 Common lysA diaminopimelate decarboxylase APL_1525 217 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 126208980 Common - cytochrome c biogenesis factor-like protein APL_1516 40 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 126207678 Common fis DNA-binding protein Fis APL_0190 97 COG2901 Fis, Factor for inversion stimulation Fis, transcriptional activator Transcription / DNA replication, recombination, and repair 126208618 Common - putative periplasmic protein APL_1148 33 COG3439 COG3439, Uncharacterized conserved protein Function unknown 126208964 Common - hypothetical protein APL_1500 20 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 126208407 Common iscS cysteine desulfurase APL_0931 240 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 126207806 Common nhaB sodium/proton antiporter APL_0322 26 COG3067 NhaB, Na+/H+ antiporter Inorganic ion transport and metabolism 126208755 Common - hypothetical protein APL_1289 73 COG2854 Ttg2D, ABC-type transport system involved in resistance to organic solvents, auxiliary component Secondary metabolites biosynthesis, transport, and catabolism 126208046 Common afuB_2 Ferric transport system permease protein APL_0564 212 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 126208994 Common poxA lysyl-tRNA synthetase APL_1530 222 COG2269 COG2269, Truncated, possibly inactive, lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 126207636 Common rnr1 ribonucleotide-diphosphate reductase subunit alpha APL_0148 214 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 126209141 Common - twin-argninine leader-binding protein DmsD APL_1677 25 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 126208425 Common - hypothetical protein APL_0949 3 None None None 126209211 Common comM Competence protein comM APL_1747 207 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 126208572 Pathogen - hypothetical protein APL_1100 1 None None None 126208842 Common phnA alkylphosphonate uptake protein APL_1378 76 COG2824 PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism Inorganic ion transport and metabolism 126208564 Common - hypothetical protein APL_1092 33 COG3326 COG3326, Predicted membrane protein Function unknown 126208122 Common rbfA ribosome-binding factor A APL_0640 173 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 126208863 Common fusA elongation factor G APL_1399 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 126208704 Common malF maltose transporter membrane protein APL_1238 144 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 126209252 Common trmD tRNA (guanine-N(1)-)-methyltransferase APL_1788 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 126209150 Common fucU fucose operon FucU protein APL_1686 39 COG4154 FucU, Fucose dissimilation pathway protein FucU Carbohydrate transport and metabolism 126207928 Common - hypothetical protein APL_0444 75 COG1556 COG1556, Uncharacterized conserved protein Function unknown 126209062 Common mrdB rod shape-determining protein APL_1598 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 126207777 Common - putative type I site-specific restriction-modification system, R (restriction) subunit APL_0293 136 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 126208164 Common dapB dihydrodipicolinate reductase APL_0684 217 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 126209067 Common - putative amino-acid ABC transporter ATP-binding protein APL_1603 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 126208232 Common yecO S-adenosyl-L-methionine-dependent methyltransferase APL_0754 52 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 126207908 Common cvpA colicin V production protein APL_0424 119 COG1286 CvpA, Uncharacterized membrane protein, required for colicin V production General function prediction only 126209419 Common crp cAMP-regulatory protein APL_1965 165 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 126208069 Common acrB acriflavine resistance protein APL_0587 180 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 126207790 Common djlA Dna-J like membrane chaperone protein APL_0306 74 COG1076 DjlA, DnaJ-domain-containing proteins 1 Posttranslational modification, protein turnover, chaperones 126209055 Common - hypothetical protein APL_1591 32 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 126207757 Common thrCA putative threonine synthase APL_0269 209 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 126208619 Common aspS aspartyl-tRNA synthetase APL_1149 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126208810 Common ftsY cell division protein FtsY-like protein APL_1346 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 126208892 Common napG quinol dehydrogenase periplasmic component APL_1428 54 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 126209160 Common hcsB capsule polysaccharide modification protein HcsB APL_1696 30 COG3562 KpsS, Capsule polysaccharide export protein Cell envelope biogenesis, outer membrane 126208568 Common - hypothetical protein APL_1096 47 COG3525 Chb, N-acetyl-beta-hexosaminidase Carbohydrate transport and metabolism 126207728 Common - tetratricopeptide repeat (TPR) family protein APL_0240 43 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 126208429 Pathogen - hypothetical protein APL_0953 2 None None None 126207846 Common ung uracil-DNA glycosylase APL_0362 128 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 126208452 Common ilvY DNA-binding transcriptional regulator IlvY APL_0978 180 COG0583 LysR, Transcriptional regulator Transcription 126208628 Common rluB ribosomal large subunit pseudouridine synthase B APL_1160 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 126209337 Common - hypothetical protein APL_1875 4 None None None 126208920 Common slyD FKBP-type peptidyl-prolyl cis-trans isomerase SlyD APL_1456 112 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 126208053 Common gntR HTH-type transcriptional regulator APL_0571 159 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 126208890 Common napB nitrate reductase cytochrome c-type subunit APL_1426 41 COG3043 NapB, Nitrate reductase cytochrome c-type subunit Energy production and conversion 126208636 Common - hypothetical protein APL_1168 37 COG2841 COG2841, Uncharacterized protein conserved in bacteria Function unknown 126207797 Common - deoxyguanosinetriphosphate triphosphohydrolase-like protein APL_0313 159 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 126209311 Common lldD L-lactate dehydrogenase APL_1849 117 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 126209335 Common dapE succinyl-diaminopimelate desuccinylase APL_1873 217 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 126209189 Common - hypothetical protein APL_1725 6 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 126208718 Common - hypothetical protein APL_1252 166 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 126208209 Common pmbA antibiotic maturation factor APL_0729 156 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 126208244 Common rec2 recombination protein 2 APL_0766 141 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 126207560 Common ilvE branched-chain amino acid aminotransferase APL_0072 191 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 126207518 Common prfC peptide chain release factor 3 APL_0030 249 COG4108 PrfC, Peptide chain release factor RF-3 Translation, ribosomal structure and biogenesis 126209414 Common miaA tRNA delta(2)-isopentenylpyrophosphate transferase APL_1960 213 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 126208185 Common - putative methylation subunit, type III restriction-modification system APL_0705 75 COG2189 COG2189, Adenine specific DNA methylase Mod DNA replication, recombination, and repair 126207752 Common - putative ABC transporter ATP-binding protein APL_0264 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 126208848 Common fabH 3-oxoacyl-(acyl carrier protein) synthase III APL_1384 232 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 126208943 Common - thioredoxin-like protein APL_1479 53 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 126209282 Common rpe ribulose-phosphate 3-epimerase APL_1820 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 126208853 Common - hypothetical protein APL_1389 218 COG4536 CorB, Putative Mg2+ and Co2+ transporter CorB Inorganic ion transport and metabolism 126208150 Common - putative Fe2+/Pb2+ permease APL_0670 3 None None None 126208546 Common thiI thiamine biosynthesis protein ThiI APL_1074 94 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 126208774 Common pgl 6-phosphogluconolactonase APL_1310 138 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 126208285 Common lysS lysyl-tRNA synthetase APL_0809 249 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 126208715 Common sapF peptide transport system ATP-binding protein SapF APL_1249 249 COG4167 SapF, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126208673 Common - putative glutathione S-transferase APL_1205 96 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 126208830 Common - hypothetical protein APL_1366 74 COG4623 COG4623, Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein Cell envelope biogenesis, outer membrane 126208640 Common purD phosphoribosylamine--glycine ligase APL_1172 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 126209171 Common - hypothetical protein APL_1707 3 None None None 126208945 Common oxyR DNA-binding transcriptional regulator OxyR APL_1481 192 COG0583 LysR, Transcriptional regulator Transcription 126207580 Common sirA sulfurtransferase APL_0092 99 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 126208321 Common gmhB D,D-heptose 1,7-bisphosphate phosphatase APL_0845 132 COG0241 HisB, Histidinol phosphatase and related phosphatases Amino acid transport and metabolism 126209022 Common rpsT 30S ribosomal protein S20 APL_1558 51 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 126209080 Common ureC urease subunit alpha APL_1616 96 COG0804 UreC, Urea amidohydrolase (urease) alpha subunit Amino acid transport and metabolism 126207756 Common - putative translation initiation inhibitor APL_0268 168 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 126207684 Common - hypothetical protein APL_0196 3 COG4972 PilM, Tfp pilus assembly protein, ATPase PilM Cell motility and secretion / Intracellular trafficking and secretion 126208599 Common - hypothetical protein APL_1129 10 COG3783 CybC, Soluble cytochrome b562 Energy production and conversion 126208897 Common - transposase APL_1433 144 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 126209117 Common - F0F1 ATP synthase subunit I APL_1653 5 COG3312 AtpI, F0F1-type ATP synthase, subunit I Energy production and conversion 126207878 Common rpoE RNA polymerase sigma factor RpoE APL_0394 173 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 126208449 Common - hypothetical protein APL_0975 167 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 126209122 Common - hypothetical protein APL_1658 86 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 126209030 Pathogen - hypothetical protein APL_1566 1 None None None 126208517 Common - aminotransferase AlaT APL_1043 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 126209070 Common - regulator of cell morphogenesis and NO signaling APL_1606 44 COG2846 COG2846, Regulator of cell morphogenesis and NO signaling Cell division and chromosome partitioning 126208532 Common - hypothetical protein APL_1060 24 COG3111 COG3111, Uncharacterized conserved protein Function unknown 126209167 Common - putative L-xylulose 5-phosphate 3-epimerase APL_1703 27 COG3623 SgaU, Putative L-xylulose-5-phosphate 3-epimerase Carbohydrate transport and metabolism 126208565 Common - hypothetical protein APL_1093 36 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 126208604 Common orn oligoribonuclease APL_1134 88 COG1949 Orn, Oligoribonuclease (3'->5' exoribonuclease) RNA processing and modification 126208766 Common - hypothetical protein APL_1300 110 None None None 126207935 Common sucD succinyl-CoA ligase [ADP-forming] subunit alpha APL_0451 216 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 126209023 Common trkA potassium transporter peripheral membrane component APL_1559 138 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 126208033 Common tadB tight adherence protein B APL_0551 76 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 126207615 Common yfeD putative iron transport system membrane protein APL_0127 187 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 126208588 Common recQ ATP-dependent DNA helicase RecQ APL_1116 238 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 126207979 Common - putative DNA-methyltransferase APL_0495 55 COG0338 Dam, Site-specific DNA methylase DNA replication, recombination, and repair 126208163 Common metB cystathionine gamma-synthase APL_0683 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 126209149 Common fucK L-fuculokinase APL_1685 181 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 126209012 Common - hypothetical protein APL_1548 36 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 126207708 Common - putative lipoprotein APL_0220 30 COG1462 CsgG, Uncharacterized protein involved in formation of curli polymers Cell envelope biogenesis, outer membrane 126207860 Common lon ATP-dependent protease La APL_0376 220 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 126208406 Common nifU scaffold protein APL_0930 155 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 126208667 Common - hypothetical protein APL_1199 155 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 126209201 Common sfsA sugar fermentation stimulation-like protein APL_1737 108 COG1489 SfsA, DNA-binding protein, stimulates sugar fermentation General function prediction only 126209484 Common map methionine aminopeptidase APL_2030 249 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 126207744 Common gmk guanylate kinase APL_0256 214 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 126207504 Common murD UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase APL_0016 211 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 126207922 Common - recombination factor protein RarA APL_0438 239 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 126209151 Common fucA L-fuculose phosphate aldolase APL_1687 161 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 126207683 Common mrcA membrane carboxypeptidase/penicillin-binding protein APL_0195 201 COG5009 MrcA, Membrane carboxypeptidase/penicillin-binding protein Cell envelope biogenesis, outer membrane 126208839 Common oadG oxaloacetate decarboxylase subunit gamma APL_1375 8 COG3630 OadG, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, gamma subunit Energy production and conversion 126208603 Common coaD phosphopantetheine adenylyltransferase APL_1133 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 126208157 Pathogen - hypothetical protein APL_0677 3 None None None 126207567 Common glpE thiosulfate sulfurtransferase GlpE APL_0079 95 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 126208657 Common - hypothetical protein APL_1189 61 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 126209465 Common aldA Putative aldehyde dehydrogenase aldA APL_2011 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 126208196 Common - iron(III) ABC transporter, permease protein APL_0716 139 COG4605 CeuC, ABC-type enterochelin transport system, permease component Inorganic ion transport and metabolism 126208129 Common ompP2 Outer membrane protein P2 precursor (OMP P2) APL_0649 21 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 126207970 Common maeB NADP-dependent malic enzyme (NADP-ME) APL_0486 202 COG0281 SfcA, Malic enzyme Energy production and conversion 126208475 Common - putative binding protein APL_1001 127 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 126207944 Common plpD lipoprotein Plp4 APL_0460 93 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 126207624 Common pyrG CTP synthetase APL_0136 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 126207575 Common nudC NADH pyrophosphatase APL_0087 103 COG2816 NPY1, NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding DNA replication, recombination, and repair 126208970 Common - hypothetical protein APL_1506 56 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 126209360 Common - hypothetical protein APL_1900 112 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 126207717 Common rluA predicted RNA pseudouridine synthase APL_0229 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 126208177 Common - putative HTH-type transcriptional regulator APL_0697 169 COG0583 LysR, Transcriptional regulator Transcription 126208413 Common - hypothetical protein APL_0937 66 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 126209038 Common - hypothetical protein APL_1574 17 COG3545 COG3545, Predicted esterase of the alpha/beta hydrolase fold General function prediction only 126208670 Common - modification methylase APL_1202 103 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 126209454 Common rpmA 50S ribosomal protein L27 APL_2000 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 126209301 Common udp uridine phosphorylase APL_1839 98 COG2820 Udp, Uridine phosphorylase Nucleotide transport and metabolism 126208556 Common - hypothetical protein APL_1084 4 None None None 126207893 Common lpxD UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase APL_0409 166 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 126209447 Common fabD Malonyl CoA-acyl carrier protein transacylase (MCT) APL_1993 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 126209453 Common rplU 50S ribosomal protein L21 APL_1999 210 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 126207994 Common - putative Clp-like protease APL_0510 134 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 126207880 Common rseC putative sigma-E factor regulatory protein APL_0396 20 COG3086 RseC, Positive regulator of sigma E activity Signal transduction mechanisms 126207898 Common uppS undecaprenyl pyrophosphate synthetase APL_0414 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 126207695 Common dxs 1-deoxy-D-xylulose-5-phosphate synthase APL_0207 225 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 126207643 Common nqrF Na(+)-translocating NADH-quinone reductase subunit F APL_0155 161 COG2871 NqrF, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF Energy production and conversion 126207780 Common - hypothetical protein APL_0296 4 None None None 126208988 Common gst glutathione S-transferase APL_1524 89 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 126209229 Common rplV 50S ribosomal protein L22 APL_1765 218 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 126208683 Common - hypothetical ABC transporter ATP-binding protein APL_1215 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 126209394 Pathogen - hypothetical protein APL_1936 2 None None None 126209040 Common kpsF arabinose-5-phosphate isomerase APL_1576 166 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 126207807 Common fadR fatty acid metabolism regulator APL_0323 51 COG2186 FadR, Transcriptional regulators Transcription 126208390 Common ppiB peptidyl-prolyl cis-trans isomerase B APL_0914 201 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 126208737 Common ndh NADH dehydrogenase APL_1271 204 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 126207987 Common rusA predicted Endodeoxyribonuclease RusA APL_0503 7 COG4570 Rus, Holliday junction resolvase DNA replication, recombination, and repair 126208926 Common - hypothetical protein APL_1462 166 COG0316 IscA, Uncharacterized conserved protein Function unknown 126209091 Common - hypothetical protein APL_1627 167 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 126209262 Common torA Trimethylamine-N-oxide reductase precursor APL_1798 175 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 126208326 Common - ABC transporter, ATP-binding/permease APL_0850 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 126208590 Common gcp O-sialoglycoprotein endopeptidase APL_1120 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 126207530 Common rlmB 23S rRNA (guanosine-2'-O-)-methyltransferase APL_0042 216 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 126208275 Common - hypothetical protein APL_0799 5 None None None 126207857 Common - hypothetical protein APL_0373 9 COG3110 COG3110, Uncharacterized protein conserved in bacteria Function unknown 126207796 Common rumA 23S rRNA 5-methyluridine methyltransferase APL_0312 199 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 126209326 Common accB Biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP) APL_1864 174 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 126208414 Common bioD dithiobiotin synthetase APL_0938 156 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 126209276 Common macA probable macrolide-specific efflux protein APL_1814 147 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 126208787 Common ptsI phosphoenolpyruvate-protein phosphotransferase APL_1323 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 126209097 Pathogen - hypothetical protein APL_1633 1 COG3134 COG3134, Predicted outer membrane lipoprotein Function unknown 126208694 Common infA translation initiation factor IF-1 APL_1228 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 126208176 Common topA DNA topoisomerase I APL_0696 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 126208902 Common - hypothetical protein APL_1438 17 COG1755 COG1755, Uncharacterized protein conserved in bacteria Function unknown 126208234 Common - hypothetical protein APL_0756 22 COG3514 COG3514, Uncharacterized protein conserved in bacteria Function unknown 126208967 Pathogen - hypothetical protein APL_1503 2 None None None 126208128 Common cpdB bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein APL_0646 124 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 126208691 Common - putative inner membrane protein APL_1223 135 COG2252 COG2252, Permeases General function prediction only 126209092 Common mtlR mannitol repressor protein APL_1628 18 COG3722 MtlR, Transcriptional regulator Transcription 126208300 Common purB adenylosuccinate lyase APL_0824 234 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 126208553 Common - homocysteine/selenocysteine methylase APL_1081 91 COG2040 MHT1, Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) Amino acid transport and metabolism 126209184 Common rplJ 50S ribosomal protein L10 APL_1720 206 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 126208025 Common rnc ribonuclease III APL_0543 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 126209049 Common cpxA ATP-binding protein APL_1585 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 126207820 Common yhgB putative ABC transporter ATP-binding protein APL_0336 249 COG1137 YhbG, ABC-type (unclassified) transport system, ATPase component General function prediction only 126208908 Common apxIA RTX-I toxin determinant A APL_1444 81 COG2931 COG2931, RTX toxins and related Ca2+-binding proteins Secondary metabolites biosynthesis, transport, and catabolism 126207578 Pathogen - hypothetical protein APL_0090 3 COG3030 FxsA, Protein affecting phage T7 exclusion by the F plasmid General function prediction only 126208723 Common phoB phosphate regulon transcriptional regulatory protein PhoB APL_1257 221 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126209137 Common rbsK ribokinase APL_1673 189 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 126208315 Common - predicted inner membrane transport permease APL_0839 122 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 126208093 Common - putative lipoprotein APL_0611 139 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 126207735 Common rho transcription termination factor Rho APL_0247 208 COG1158 Rho, Transcription termination factor Transcription 126207978 Common rdgC recombination associated protein APL_0494 53 COG2974 RdgC, DNA recombination-dependent growth factor C DNA replication, recombination, and repair 126208822 Common - hypothetical protein APL_1358 4 COG4679 COG4679, Phage-related protein Function unknown 126207594 Common putA bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase APL_0106 220 COG4230 COG4230, Delta 1-pyrroline-5-carboxylate dehydrogenase Energy production and conversion 126209207 Common - Ser/Thr protein phosphatase family protein APL_1743 138 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 126208672 Common - esterase APL_1204 108 COG0627 COG0627, Predicted esterase General function prediction only 126209011 Common hcr HCP oxidoreductase, NADH-dependent APL_1547 155 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 126208796 Common hybA hydrogenase 2 protein HybA APL_1332 162 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 126208876 Common - putative oxidoreductase APL_1412 179 COG4989 COG4989, Predicted oxidoreductase General function prediction only 126209078 Common ureE urease accessory protein UreE APL_1614 18 COG2371 UreE, Urease accessory protein UreE Posttranslational modification, protein turnover, chaperones 126207664 Common pcnB putative poly(A) polymerase APL_0176 213 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 126207496 Common sohB predicted inner membrane peptidase APL_0008 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 126208212 Common ubiX aromatic acid decarboxylase APL_0732 152 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 126208140 Common ansB probable L-asparaginase APL_0660 139 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 126208825 Common - hypothetical protein APL_1361 209 COG0313 COG0313, Predicted methyltransferases General function prediction only 126208016 Common thiS thiamine biosynthesis protein ThiS APL_0534 21 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 126209366 Common dnaK Chaperone protein dnaK APL_1906 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 126207650 Common - putative phosphatase APL_0162 178 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 126208520 Common - lysine exporter protein APL_1046 121 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 126208259 Common - putative ATP-dependent helicase APL_0781 151 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 126208294 Common - transthyretin-like periplasmic protein APL_0818 63 COG2351 COG2351, Transthyretin-like protein General function prediction only 126208034 Common tadA tight adherence protein A APL_0552 161 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 126207552 Common dppA periplasmic dipeptide transport protein APL_0064 214 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 126208571 Common - hypothetical protein APL_1099 169 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 126207556 Common dppF dipeptide transporter ATP-binding subunit APL_0068 249 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 126208728 Common - transcriptional regulator MerR family APL_1262 145 COG0789 SoxR, Predicted transcriptional regulators Transcription 126208086 Common fieF cation-efflux pump FieF APL_0604 200 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 126209058 Common lipB lipoyltransferase APL_1594 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 126208620 Common ntpA dATP pyrophosphohydrolase APL_1150 49 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 126208732 Common - putative dehydrogenase APL_1266 234 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 126208358 Common - hypothetical protein APL_0882 10 None None None 126207984 Common - hypothetical protein APL_0500 3 None None None 126209439 Common tatA twin argininte translocase protein A APL_1985 49 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 126208149 Common - putative iron dependent peroxidase APL_0669 46 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 126208717 Common pgk phosphoglycerate kinase APL_1251 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 126207854 Common recB exodeoxyribonuclease V beta chain APL_0370 211 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 126208104 Common tdk thymidine kinase APL_0622 96 COG1435 Tdk, Thymidine kinase Nucleotide transport and metabolism 126209355 Common lgt Prolipoprotein diacylglyceryl transferase APL_1895 208 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 126207648 Common proC pyrroline-5-carboxylate reductase APL_0160 213 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 126207600 Common hemE uroporphyrinogen decarboxylase APL_0112 181 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 126208705 Common malG maltose transporter permease APL_1239 142 COG3833 MalG, ABC-type maltose transport systems, permease component Carbohydrate transport and metabolism 126209140 Common dmsC anaerobic dimethyl sulfoxide reductase chain C APL_1676 32 COG3302 DmsC, DMSO reductase anchor subunit General function prediction only 126209253 Common rplS 50S ribosomal protein L19 APL_1789 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 126208957 Common - hypothetical protein APL_1493 145 COG1741 COG1741, Pirin-related protein General function prediction only 126208448 Common - hypothetical protein APL_0974 23 COG3092 COG3092, Uncharacterized protein conserved in bacteria Function unknown 126209127 Common - hypothetical transposase-like protein APL_1663 144 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 126207609 Common - hypothetical protein APL_0121 74 COG2989 COG2989, Uncharacterized protein conserved in bacteria Function unknown 126208252 Common pyrD dihydroorotate dehydrogenase 2 APL_0774 232 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 126207950 Common fhs formyltetrahydrofolate synthetase APL_0466 89 COG2759 MIS1, Formyltetrahydrofolate synthetase Nucleotide transport and metabolism 126208374 Common - putative oxalate/formate antiporter APL_0898 95 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 126208557 Common argE acetylornithine deacetylase APL_1085 189 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 126208769 Common zipA cell division protein ZipA APL_1303 40 COG3115 ZipA, Cell division protein Cell division and chromosome partitioning 126207900 Common - N-acetyl-D-glucosamine kinase APL_0416 142 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 126208123 Common truB tRNA pseudouridine synthase B APL_0641 245 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 126209370 Common xylG D-xylose transport ATP-binding protein xylG APL_1910 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 126207883 Common ksgA dimethyladenosine transferase APL_0399 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 126209210 Common - hypothetical protein APL_1746 42 COG3657 COG3657, Uncharacterized protein conserved in bacteria Function unknown 126209061 Common - possible rare lipoprotein A RlpA-like protein APL_1597 137 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 126207776 Common - putative Type I restriction enzyme EcoR124II specificity protein APL_0290 45 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 126208231 Common - putative esterase/lipase APL_0753 80 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 126208338 Common truC tRNA pseudouridine synthase C APL_0862 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 126208809 Common fstE cell division ATP-binding protein FtsE APL_1345 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 126207907 Common rnhA ribonuclease H APL_0423 175 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 126208854 Common - hypothetical sodium-dependent transporter APL_1390 88 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 126208963 Common thrC threonine synthase APL_1499 187 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 126207546 Common yfhL putative ferredoxin APL_0058 104 COG2768 COG2768, Uncharacterized Fe-S center protein General function prediction only 126207957 Common polA DNA polymerase I APL_0473 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 126207879 Common rseA putative sigma-E factor negative regulatory protein APL_0395 22 COG3073 RseA, Negative regulator of sigma E activity Signal transduction mechanisms 126209233 Common rpsQ 30S ribosomal protein S17 APL_1769 236 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 126208579 Common plsB glycerol-3-phosphate acyltransferase APL_1107 48 COG2937 PlsB, Glycerol-3-phosphate O-acyltransferase Lipid metabolism 126208045 Common afuA_2 Fe3+ ABC transporter, iron-binding protein APL_0563 112 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 126209280 Common - hypothetical protein APL_1818 185 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 126209039 Common - hypothetical protein APL_1575 4 None None None 126208974 Common gpsA NAD(P)H-dependent glycerol-3-phosphate dehydrogenase APL_1510 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 126209428 Common argD diaminobutyrate--2-oxoglutarate aminotransferase APL_1974 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 126208635 Common - hypothetical protein APL_1167 13 None None None 126209377 Common metJ transcriptional repressor protein MetJ APL_1917 23 COG3060 MetJ, Transcriptional regulator of met regulon Transcription / Amino acid transport and metabolism 126209472 Common purC phosphoribosylaminoimidazole-succinocarboxamide synthase APL_2018 189 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 126208808 Common ftsX cell division protein FtsX APL_1344 122 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 126207675 Common pykA pyruvate kinase APL_0187 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 126209289 Common recG ATP-dependent DNA helicase recG APL_1827 218 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 126207885 Common pyrR pyrimidine regulatory protein PyrR APL_0401 114 COG2065 PyrR, Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase Nucleotide transport and metabolism 126208591 Common - putative lipoprotein APL_1121 123 COG4105 ComL, DNA uptake lipoprotein General function prediction only 126209100 Common - hypothetical protein APL_1636 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 126207965 Common - hypothetical protein APL_0481 32 None None None 126207542 Common grxA glutaredoxin 1 APL_0054 69 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 126209400 Common icc cyclic 3',5'-adenosine monophosphate phosphodiesterase APL_1942 91 COG1409 Icc, Predicted phosphohydrolases General function prediction only 126209196 Common - hypothetical protein APL_1732 10 COG3059 COG3059, Predicted membrane protein Function unknown 126208344 Common serS seryl-tRNA synthetase APL_0868 244 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 126207933 Common - putative integral membrane protein APL_0449 66 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 126208351 Common yacG putative zinc-binding protein APL_0875 59 COG3024 COG3024, Uncharacterized protein conserved in bacteria Function unknown 126208487 Common groES 10 kDa chaperonin APL_1013 216 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 126208779 Common hslO Hsp33-like chaperonin APL_1315 137 COG1281 COG1281, Disulfide bond chaperones of the HSP33 family Posttranslational modification, protein turnover, chaperones 126208395 Common irp iron-regulated outer membrane protein APL_0919 60 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 126209323 Common dapD 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase APL_1861 150 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 126209384 Common pgaD biofilm PGA synthesis protein pgaD APL_1924 1 None None None 126208263 Common - hypothetical protein APL_0785 26 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 126209219 Common nagB glucosamine-6-phosphate deaminase APL_1755 82 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 126209338 Common folP Dihydropteroate synthase APL_1876 218 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 126209245 Common rpsM 30S ribosomal protein S13 APL_1781 244 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 126209343 Common ptrA protease 3 precursor APL_1883 189 COG1025 Ptr, Secreted/periplasmic Zn-dependent peptidases, insulinase-like Posttranslational modification, protein turnover, chaperones 126208533 Common - hypothetical protein APL_1061 20 COG3111 COG3111, Uncharacterized conserved protein Function unknown 126208678 Common - hypothetical protein APL_1210 80 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 126208151 Common trpH TrpH-like protein APL_0671 128 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 126207502 Common murF UDP-MurNAc-pentapeptide synthetase APL_0014 208 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 126209388 Common - hypothetical protein APL_1928 54 COG1238 COG1238, Predicted membrane protein Function unknown 126208441 Common gltS sodium/glutamate symport carrier protein APL_0967 51 COG0786 GltS, Na+/glutamate symporter Amino acid transport and metabolism 126207704 Common - hypothetical protein APL_0216 21 None None None 126208193 Common dnaB replicative DNA helicase APL_0713 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 126208089 Common nfnB putative NAD(P)H nitroreductase APL_0607 102 COG0778 NfnB, Nitroreductase Energy production and conversion 126209398 Common - hypothetical protein APL_1940 183 COG0759 COG0759, Uncharacterized conserved protein Function unknown 126208158 Common efp elongation factor P APL_0678 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 126209432 Common - hypothetical protein APL_1978 23 COG3085 COG3085, Uncharacterized protein conserved in bacteria Function unknown 126209007 Common wecG putative UDP-N-acetyl-D-mannosaminuronic acid transferase APL_1543 109 COG1922 WecG, Teichoic acid biosynthesis proteins Cell envelope biogenesis, outer membrane 126207772 Common ruvB Holliday junction DNA helicase B APL_0284 221 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 126207714 Common - hypothetical protein APL_0226 3 COG4639 COG4639, Predicted kinase General function prediction only 126208466 Common nrdA ribonucleotide-diphosphate reductase subunit alpha APL_0992 197 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 126208345 Common abgB aminobenzoyl-glutamate utilization-like protein APL_0869 172 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 126207539 Common - 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase APL_0051 105 COG1778 COG1778, Low specificity phosphatase (HAD superfamily) General function prediction only 126208172 Common moaD molybdopterin-converting factor subunit 1 APL_0692 73 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 126209307 Common sbp sulfate-binding protein precursor APL_1845 88 COG1613 Sbp, ABC-type sulfate transport system, periplasmic component Inorganic ion transport and metabolism 126208322 Common bcp thioredoxin-dependent thiol peroxidase APL_0846 212 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 126208874 Common tnaB tTryptophan-specific transport protein APL_1410 31 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 126207760 Common yfeA iron (chelated) ABC transporter, periplasmic-binding protein APL_0272 172 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 126207890 Common dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase APL_0406 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 126208626 Common metR HTH-type transcriptional regulator MetR APL_1158 188 COG0583 LysR, Transcriptional regulator Transcription 126209483 Common - hypothetical protein APL_2029 85 COG1738 COG1738, Uncharacterized conserved protein Function unknown 126208144 Common - hypothetical protein APL_0664 56 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 126209158 Common - antigenic protein, ABC transporter-like protein APL_1694 185 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 126209411 Common - Lipoprotein_5 domain containing protein APL_1957 3 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 126207738 Common thrA bifunctional aspartokinase I/homeserine dehydrogenase I APL_0250 235 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 126208767 Common galE UDP-glucose 4-epimerase APL_1301 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 126208115 Common hsdM3 putative type I modification enzyme APL_0633 160 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 126208165 Common mtfA putative RNA 2'-O-ribose methyltransferase MtfA APL_0685 45 COG2933 COG2933, Predicted SAM-dependent methyltransferase General function prediction only 126208265 Common - putative ATPase APL_0787 29 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 126209302 Common ubiC 4-hydroxybenzoate synthetase (chorismate lyase) APL_1840 26 COG3161 UbiC, 4-hydroxybenzoate synthetase (chorismate lyase) Coenzyme metabolism 126209235 Common rplE 50S ribosomal protein L5 APL_1771 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 126207623 Common ansB L-asparaginase II APL_0135 140 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 126207810 Common prfB peptide chain release factor 2 APL_0326 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 126209000 Common murQ N-acetylmuramic acid-6-phosphate etherase APL_1536 103 COG2103 COG2103, Predicted sugar phosphate isomerase General function prediction only 126207672 Common tyrA bifunctional chorismate mutase/prephenate dehydrogenase APL_0184 96 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 126207924 Common - hypothetical protein APL_0440 72 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 126207927 Common - autotransporter adhesin APL_0443 145 COG5295 Hia, Autotransporter adhesin Intracellular trafficking and secretion / Extracellular structures 126208510 Common pflB formate acetyltransferase APL_1036 58 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 126208661 Common - putative type I restriction-modification system, S subunit APL_1193 70 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 126207863 Common glpA sn-glycerol-3-phosphate dehydrogenase subunit A APL_0379 161 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 126208939 Common rpoD RNA polymerase sigma factor RpoD APL_1475 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 126208605 Common - hypothetical protein APL_1135 198 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 126208701 Common lamB maltoporin APL_1235 27 COG4580 LamB, Maltoporin (phage lambda and maltose receptor) Carbohydrate transport and metabolism 126208566 Common - putative transcription regulator protein APL_1094 187 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 126208888 Common oxaA putative inner membrane protein translocase component YidC APL_1424 213 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 126207503 Common mraY phospho-N-acetylmuramoyl-pentapeptide-transferase APL_0015 226 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 126207943 Common recJ single-stranded-DNA-specific exonuclease RecJ APL_0459 192 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 126208126 Common pta phosphate acetyltransferase APL_0644 175 COG0280 Pta, Phosphotransacetylase Energy production and conversion 126208246 Common dgkA diacylglycerol kinase APL_0768 113 COG0818 DgkA, Diacylglycerol kinase Cell envelope biogenesis, outer membrane 126208432 Common apxIIA RTX-II toxin determinant A APL_0956 66 COG2931 COG2931, RTX toxins and related Ca2+-binding proteins Secondary metabolites biosynthesis, transport, and catabolism 126208598 Common - membrane protein APL_1128 83 COG0628 PerM, Predicted permease General function prediction only 126208243 Common queA S-adenosylmethionine:tRNA ribosyltransferase-isomerase APL_0765 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 126208206 Common - carbonic anhydrase APL_0726 150 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 126207687 Common - hypothetical protein APL_0199 3 None None None 126209497 Common - hypothetical protein APL_2043 1 None None None 126208953 Common tpx putative thiol peroxidase APL_1489 104 COG2077 Tpx, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 126209368 Common xylA xylose isomerase APL_1908 68 COG2115 XylA, Xylose isomerase Carbohydrate transport and metabolism 126207751 Common - putative ABC transport system permease APL_0263 168 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 126208656 Common - hypothetical protein APL_1188 6 None None None 126207634 Common dusA tRNA-dihydrouridine synthase A APL_0146 208 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 126208380 Common kdkA 3-deoxy-D-manno-octulosonic-acid kinase APL_0904 21 COG3642 COG3642, Mn2+-dependent serine/threonine protein kinase Signal transduction mechanisms 126208975 Common cysE serine acetyltransferase APL_1511 206 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 126207874 Common - hypothetical protein APL_0390 100 COG0385 COG0385, Predicted Na+-dependent transporter General function prediction only 126208094 Common - putative transposase APL_0612 143 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 126207785 Common tolR colicin uptake protein TolR APL_0301 89 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 126208671 Common - hypothetical protein APL_1203 28 COG3124 COG3124, Uncharacterized protein conserved in bacteria Function unknown 126208410 Common ogt methylated-DNA--protein-cysteine S-methyltransferase APL_0934 216 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 126209194 Common - hypothetical protein APL_1730 24 COG4456 VagC, Virulence-associated protein and related proteins Function unknown 126208370 Common fdxH formate dehydrogenase, iron-sulfur subunit APL_0894 160 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 126208483 Common hemD putative uroporphyrinogen-III synthase APL_1009 57 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 126208971 Common tig trigger factor APL_1507 213 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 126207561 Common ydhD monothiol glutaredoxin-like protein APL_0073 126 COG0278 COG0278, Glutaredoxin-related protein Posttranslational modification, protein turnover, chaperones 126208948 Common - hypothetical protein APL_1484 7 None None None 126209221 Common fumC fumarate hydratase APL_1757 234 COG0114 FumC, Fumarase Energy production and conversion 126207997 Common - putative phage tail component APL_0513 5 None None None 126209345 Common - hypothetical protein APL_1885 4 None None None 126207517 Common - ABC transporter periplasmic protein APL_0029 191 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 126207656 Common - hypothetical protein APL_0168 133 COG2860 COG2860, Predicted membrane protein Function unknown 126208919 Common ilvA threonine dehydratase APL_1455 223 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 126209285 Common pbpB Penicillin-binding protein 1B (PBP1b) APL_1823 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 126208439 Common - hypothetical protein APL_0965 20 COG3078 COG3078, Uncharacterized protein conserved in bacteria Function unknown 126207755 Common - hypothetical protein APL_0267 48 COG2964 COG2964, Uncharacterized protein conserved in bacteria Function unknown 126207853 Common norM putative multidrug resistance protein NorM APL_0369 166 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 126207899 Common gloB putative hydroxyacylglutathione hydrolase APL_0415 182 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 126207971 Common rplY 50S ribosomal protein L25 APL_0487 149 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 126208070 Common glmU bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase APL_0588 231 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 126208464 Common - transposase APL_0990 117 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 126208995 Common dapF diaminopimelate epimerase APL_1531 203 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 126208184 Common - hypothetical protein APL_0704 14 None None None 126209121 Common - putative amino-acid ABC transporter-binding protein APL_1657 173 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 126208934 Common - hypothetical protein APL_1470 14 None None None 126209258 Common - pseudoazurin APL_1794 28 COG3794 PetE, Plastocyanin Energy production and conversion 126208005 Common - phage-related minor tail protein L APL_0521 14 COG4672 gp18, Phage-related protein Function unknown 126208932 Common - hypothetical protein APL_1468 4 None None None 126207916 Common leuB 3-isopropylmalate dehydrogenase APL_0432 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 126209172 Common - hypothetical protein APL_1708 12 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 126208639 Common rpsF 30S ribosomal protein S6 APL_1171 198 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 126209477 Common hisB imidazole glycerol-phosphate dehydratase/histidinol phosphatase APL_2023 217 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 126208503 Common - hypothetical protein APL_1029 3 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 126209310 Common cysA Sulfate/thiosulfate import ATP-binding protein cysA APL_1848 249 COG1118 CysA, ABC-type sulfate/molybdate transport systems, ATPase component Inorganic ion transport and metabolism 126209148 Common fucI L-fucose isomerase APL_1684 19 COG2407 FucI, L-fucose isomerase and related proteins Carbohydrate transport and metabolism 126207966 Common - predicted transcriptional regulator APL_0482 113 COG0640 ArsR, Predicted transcriptional regulators Transcription 126208121 Common infB translation initiation factor IF-2 APL_0639 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 126209403 Common - hypothetical protein APL_1945 9 COG2091 Sfp, Phosphopantetheinyl transferase Coenzyme metabolism 126208912 Common fbpC ferric transporter ATP-binding subunit APL_1448 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 126209336 Common arsC ArsC protein APL_1874 103 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 126207845 Common grcA autonomous glycyl radical cofactor GrcA APL_0361 52 COG3445 COG3445, Acid-induced glycyl radical enzyme General function prediction only 126207877 Common leuA 2-isopropylmalate synthase APL_0393 217 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 126208026 Common era GTP-binding protein Era APL_0544 232 COG1159 Era, GTPase General function prediction only 126207727 Common secA preprotein translocase subunit SecA APL_0239 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 126208792 Common hypD hydrogenase isoenzymes formation protein HypD APL_1328 109 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 126209112 Common atpA F0F1 ATP synthase subunit alpha APL_1648 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 126209381 Common pgaA biofilm PGA synthesis protein PgaA precursor APL_1921 14 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 126208215 Common - translation initiation factor Sui1 APL_0735 50 COG0023 SUI1, Translation initiation factor 1 (eIF-1/SUI1) and related proteins Translation, ribosomal structure and biogenesis 126207679 Common - predicted Na+-dependent transporters of the SNF family APL_0191 88 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 126209459 Common rsmC 16S ribosomal RNA m2G1207 methyltransferase APL_2005 122 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 126209359 Common ppa inorganic pyrophosphatase APL_1899 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 126208580 Common lexA LexA repressor APL_1108 166 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 126208540 Common secF preprotein translocase subunit SecF APL_1068 215 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 126209195 Common - hypothetical protein APL_1731 61 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 126209169 Common - FKBP-type peptidyl-prolyl cis-trans isomerase APL_1705 143 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 126209084 Common cbiO predicted ABC transport ATP-binding protein CbiO APL_1620 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 126208615 Common pabB para-aminobenzoate synthase component I APL_1145 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 126209346 Pathogen - hypothetical protein APL_1886 2 None None None 126208877 Common - putative long-chain-fatty-acid--CoA ligase APL_1413 211 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 126209101 Common mtn MTA/SAH nucleosidase APL_1637 98 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 126208394 Common - transposase APL_0918 114 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 126207838 Common rsuA ribosomal small subunit pseudouridine synthase A APL_0354 193 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 126207775 Common - hypothetical protein APL_0289 11 None None None 126207645 Common - hypothetical protein APL_0157 21 COG2991 COG2991, Uncharacterized protein conserved in bacteria Function unknown 126208669 Common - hypothetical protein APL_1201 15 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 126207652 Common - hypothetical protein APL_0164 14 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 126209367 Common xylB Xylulose kinase (Xylulokinase) APL_1907 183 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 126208308 Common gpmA 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase APL_0832 155 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 126207931 Common lctP putative L-lactate permease APL_0447 103 COG1620 LldP, L-lactate permease Energy production and conversion 126209471 Common - hypothetical protein APL_2017 15 COG4390 COG4390, Uncharacterized protein conserved in bacteria Function unknown 126209159 Common kpsC capsule polysaccharide modification protein LipA APL_1695 30 COG3563 KpsC, Capsule polysaccharide export protein Cell envelope biogenesis, outer membrane 126208075 Common guaB inositol-5-monophosphate dehydrogenase APL_0593 242 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 126208983 Common lspA lipoprotein signal peptidase APL_1519 154 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 126208616 Common rmuC DNA recombination protein RmuC-like protein APL_1146 131 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 126209324 Common aroQ 3-dehydroquinate dehydratase APL_1862 169 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 126208350 Common holA DNA polymerase III subunit delta APL_0874 71 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 126208367 Common fdhD formate dehydrogenase accessory protein-like protein APL_0891 135 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 126207726 Pathogen - hypothetical protein APL_0238 2 None None None 126208361 Common - hypothetical protein APL_0885 104 COG0730 COG0730, Predicted permeases General function prediction only 126209161 Common - hypothetical protein APL_1697 5 None None None 126207808 Common phoH PhoH-like protein APL_0324 199 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 126209376 Common ap2048 hypothetical protein APL_1916 15 COG3924 COG3924, Predicted membrane protein Function unknown 126209228 Common rpsS 30S ribosomal protein S19 APL_1764 246 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 126207939 Common kgd alpha-ketoglutarate decarboxylase APL_0455 149 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 126208900 Common rne ribonuclease E APL_1436 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 126208738 Common - predicted transcriptional accessory protein APL_1272 152 COG2183 Tex, Transcriptional accessory protein Transcription 126208753 Common - hypothetical protein APL_1287 51 COG5007 COG5007, Predicted transcriptional regulator, BolA superfamily Transcription 126208495 Common - alpha-glucosidase 2 APL_1021 82 COG1501 COG1501, Alpha-glucosidases, family 31 of glycosyl hydrolases Carbohydrate transport and metabolism 126208041 Common flp1 fimbrial protein Flp precursor APL_0559 4 COG3847 Flp, Flp pilus assembly protein, pilin Flp Intracellular trafficking and secretion 126208295 Common purR HTH-type transcriptional repressor PurR APL_0819 128 COG1609 PurR, Transcriptional regulators Transcription 126209354 Pathogen - hypothetical protein APL_1894 2 None None None 126208518 Common - hypothetical protein APL_1044 92 COG2962 RarD, Predicted permeases General function prediction only 126208274 Common gmhA phosphoheptose isomerase APL_0798 130 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 126208105 Common - hypothetical protein APL_0623 17 COG3074 COG3074, Uncharacterized protein conserved in bacteria Function unknown 126208120 Common nusA transcription elongation factor NusA APL_0638 216 COG0195 NusA, Transcription elongation factor Transcription 126208844 Common - hypothetical protein APL_1380 69 COG1872 COG1872, Uncharacterized conserved protein Function unknown 126209017 Common - hypothetical protein APL_1553 15 COG3765 WzzB, Chain length determinant protein Cell envelope biogenesis, outer membrane 126207564 Common tonB2 protein TonB2 APL_0076 8 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 126208490 Common - putative nucleoside transporter APL_1016 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 126209213 Common - acyl-CoA thioester hydrolase YfbB APL_1749 60 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 126208166 Common - hypothetical protein APL_0686 42 COG2363 COG2363, Uncharacterized small membrane protein Function unknown 126209128 Common - transposase APL_1664 20 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 126207904 Common pbpG penicillin-binding protein 7 precursor APL_0420 105 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 126208405 Common iscA iron-binding protein IscA APL_0929 165 COG0316 IscA, Uncharacterized conserved protein Function unknown 126209063 Common mrdA penicillin-binding protein 2 APL_1599 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 126209152 Common fucP L-fucose permease APL_1688 47 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 126207545 Common - hypothetical protein APL_0057 100 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 126207769 Common potB spermidine/putrescine ABC transporter membrane protein APL_0281 217 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 126208048 Common rpsB 30S ribosomal protein S2 APL_0566 216 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 126208411 Common - aerobic respiration control sensor protein APL_0935 224 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126209295 Common - putative sulfite oxidase subunit YedZ APL_1833 73 COG2717 COG2717, Predicted membrane protein Function unknown 126207660 Common msbB lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase APL_0172 83 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 126208702 Common malK maltose/maltodextrin transporter ATP-binding protein APL_1236 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 126208710 Common - hypothetical protein APL_1244 5 None None None 126208339 Common - hypothetical protein APL_0863 3 COG3140 COG3140, Uncharacterized protein conserved in bacteria Function unknown 126208179 Common aroA 3-phosphoshikimate 1-carboxyvinyltransferase APL_0699 228 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 126207996 Pathogen - hypothetical protein APL_0512 1 None None None 126208747 Common - hypothetical protein APL_1281 75 COG2166 COG2166, SufE protein probably involved in Fe-S center assembly General function prediction only 126209132 Common rbsR ribose operon repressor APL_1668 130 COG1609 PurR, Transcriptional regulators Transcription 126208282 Common xseB exodeoxyribonuclease VII small subunit APL_0806 83 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 126209183 Common rplA 50S ribosomal protein L1 APL_1719 243 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 126207587 Common ilvG Acetolactate synthase isozyme II large subunit (AHAS-II) APL_0099 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 126208918 Common mrsA phosphoglucosamine mutase APL_1454 241 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 126208258 Common - hypothetical protein APL_0780 25 COG1380 COG1380, Putative effector of murein hydrolase LrgA General function prediction only 126208708 Common - putative deoxyribonuclease APL_1242 235 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 126208724 Common pstB phosphate import ATP-binding protein PstB APL_1258 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 126207736 Common cysK cysteine synthase APL_0248 219 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 126208950 Common accA acetyl-CoA carboxylase carboxyltransferase subunit alpha APL_1486 210 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 126209234 Common rplX 50S ribosomal protein L24 APL_1770 210 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 126207869 Common ribH 6,7-dimethyl-8-ribityllumazine synthase APL_0385 230 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 126207525 Common slyB outer membrane lipoprotein APL_0037 20 COG3133 SlyB, Outer membrane lipoprotein Cell envelope biogenesis, outer membrane 126208011 Common - predicted ABC-type transport system, permease component APL_0527 38 COG2215 COG2215, ABC-type uncharacterized transport system, permease component General function prediction only 126208680 Common tehA potassium-tellurite ethidium and proflavin transporter APL_1212 36 COG1275 TehA, Tellurite resistance protein and related permeases Inorganic ion transport and metabolism 126209462 Common srmB ATP-dependent RNA helicase SrmB APL_2008 238 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 126208357 Common radA DNA repair protein RadA APL_0881 214 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 126208696 Common serB phosphoserine phosphatase APL_1230 152 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 126208099 Common lrp leucine-responsive transcriptional regulator APL_0617 148 COG1522 Lrp, Transcriptional regulators Transcription 162329625 Common secD preprotein translocase subunit SecD APL_1067 223 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 126208807 Common cdd cytidine deaminase APL_1343 44 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 126208066 Common - hypothetical protein APL_0584 20 COG3082 COG3082, Uncharacterized protein conserved in bacteria Function unknown 126208289 Common mod type III restriction-modification system methyltransferase APL_0813 93 COG2189 COG2189, Adenine specific DNA methylase Mod DNA replication, recombination, and repair 126207816 Common hlpB lipoprotein HlpB APL_0332 4 None None None 126209438 Common ubiB Probable ubiquinone biosynthesis protein ubiB APL_1984 185 COG0661 AarF, Predicted unusual protein kinase General function prediction only 126208488 Common deoD purine nucleoside phosphorylase DeoD-like protein APL_1014 96 COG0813 DeoD, Purine-nucleoside phosphorylase Nucleotide transport and metabolism 126207521 Common pth peptidyl-tRNA hydrolase APL_0033 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 126208440 Common - hypothetical protein APL_0966 57 COG2985 COG2985, Predicted permease General function prediction only 126209079 Common gst putative glutathione S-transferase APL_1615 65 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 126209271 Pathogen - hypothetical protein APL_1807 3 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 126207557 Common psiE phosphate-starvation-inducible protein PsiE APL_0069 20 COG3223 COG3223, Predicted membrane protein Function unknown 126209096 Common - predicted transcriptional regulator of sugar metabolism APL_1632 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 126208266 Common - transcriptional regulatory protein APL_0788 163 COG0583 LysR, Transcriptional regulator Transcription 126209178 Common ulaA ascorbate-specific PTS system enzyme IIC APL_1714 36 COG3037 SgaT, Uncharacterized protein conserved in bacteria Function unknown 126207553 Common dppB dipeptide transport system permease protein DppB APL_0065 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 126207842 Common nfo endonuclease IV APL_0358 102 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 126208330 Common metF 5,10-methylenetetrahydrofolate reductase APL_0854 144 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 126208050 Common - hypothetical protein APL_0568 57 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 126209478 Common - hypothetical protein APL_2024 49 COG4804 COG4804, Uncharacterized conserved protein Function unknown 126208627 Common - hypothetical protein APL_1159 5 None None None 126209246 Common rpsK 30S ribosomal protein S11 APL_1782 248 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 126207593 Common uraA putative uracil permease APL_0105 124 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 126208987 Common chuW coproporphyrinogen III oxidase APL_1523 203 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 126209265 Common - hypothetical protein APL_1801 46 COG2852 COG2852, Uncharacterized protein conserved in bacteria Function unknown 126208786 Common ptsH PTS system phosphocarrier protein HPr APL_1322 52 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 126208010 Common - hypothetical protein APL_0526 21 COG3683 COG3683, ABC-type uncharacterized transport system, periplasmic component General function prediction only 126209299 Common asnA asparagine synthetase AsnA APL_1837 31 COG2502 AsnA, Asparagine synthetase A Amino acid transport and metabolism 126208783 Common ptsB PTS system sucrose-specific EIIBC component APL_1319 45 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 126208727 Common pstS phosphate-binding periplasmic protein precursor APL_1261 102 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 126208720 Common - hypothetical protein APL_1254 125 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 126209059 Common - hypothetical protein APL_1595 29 COG2921 COG2921, Uncharacterized conserved protein Function unknown 126209090 Common - hypothetical protein APL_1626 1 None None None 126208223 Common secG preprotein translocase subunit SecG APL_0743 34 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 126208017 Common thiG thiazole biosynthesis protein ThiG APL_0535 167 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 126207974 Pathogen - hypothetical protein APL_0490 1 None None None 126208059 Common pnp polynucleotide phosphorylase/polyadenylase APL_0577 241 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 126208759 Common htrA probable periplasmic serine protease do/hhoA-like precursor APL_1293 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 126208851 Common - hypothetical protein APL_1387 36 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 126208534 Common - hypothetical protein APL_1062 26 COG3111 COG3111, Uncharacterized conserved protein Function unknown 126208778 Common hslR heat shock-like protein 15 APL_1314 106 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 126208328 Common - putative FAD flavoprotein oxidase APL_0852 213 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 126209399 Common glnA Glutamine synthetase APL_1941 229 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 126208312 Common - putative transcriptional regulator APL_0836 26 COG1309 AcrR, Transcriptional regulator Transcription 126209056 Common mscL large-conductance mechanosensitive channel APL_1592 142 COG1970 MscL, Large-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 126208428 Common - putative transposase APL_0952 32 COG3677 COG3677, Transposase and inactivated derivatives DNA replication, recombination, and repair 126208447 Common - hypothetical protein APL_0973 4 None None None 126209500 Common - hypothetical protein APL_2046 68 COG2391 COG2391, Predicted transporter component General function prediction only 126208813 Common hpaC 4-hydroxyphenylacetic acid hydroxylase putative coupling protein APL_1349 106 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 126207793 Common yheS putative ABC transporter ATP-binding protein YheS APL_0309 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 126208388 Common metN DL-methionine transporter ATP-binding subunit APL_0912 249 COG1135 AbcC, ABC-type metal ion transport system, ATPase component Inorganic ion transport and metabolism 126208037 Common rcpA rough colony protein A APL_0555 134 COG4964 CpaC, Flp pilus assembly protein, secretin CpaC Intracellular trafficking and secretion 126208907 Common apxIB toxin RTX-I translocation ATP-binding protein APL_1443 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 126208233 Common fabI enoyl-[acyl-carrier-protein] reductase (NADH) APL_0755 233 COG0623 FabI, Enoyl- acyl-carrier-protein 126208114 Common folC folylpolyglutamate synthase/dihydrofolate synthase APL_0632 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 126208301 Common - hypothetical protein APL_0825 41 COG2915 COG2915, Uncharacterized protein involved in purine metabolism General function prediction only 126208901 Common - hypothetical protein APL_1437 17 None None None 126207958 Common lolA outer-membrane lipoprotein carrier protein APL_0474 66 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 126209153 Common - L-1,2-propanediol oxidoreductase APL_1689 174 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 126207829 Common fruB fructose-specific PTS IIA/HPr components APL_0345 105 COG4668 MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain Carbohydrate transport and metabolism 126207818 Common - hypothetical protein APL_0334 140 COG1660 COG1660, Predicted P-loop-containing kinase General function prediction only 126208336 Common fic filamentation induced by cAMP protein Fic-like protein APL_0860 108 COG3177 COG3177, Uncharacterized conserved protein Function unknown 126207743 Common gpt xanthine-guanine phosphoribosyltransferase APL_0255 74 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 126207876 Common - hypothetical protein APL_0392 107 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 126208143 Common pepP Xaa-Pro aminopeptidase APL_0663 240 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 126208438 Common - hypothetical protein APL_0964 17 None None None 126208768 Common ligA NAD-dependent DNA ligase LigA APL_1302 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 126207522 Common engD translation-associated GTPase APL_0034 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 126209330 Common dsbA Thiol:disulfide interchange protein dsbA precursor APL_1868 69 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 126207655 Common rnfC electron transport complex protein RnfC APL_0167 88 COG4656 RnfC, Predicted NADH:ubiquinone oxidoreductase, subunit RnfC Energy production and conversion 126209451 Common - Hypothetical protein - predicted flavoprotein APL_1997 114 COG0431 COG0431, Predicted flavoprotein General function prediction only 126207896 Common ecfE putative zinc metalloprotease APL_0412 214 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 126207622 Pathogen - hypothetical protein APL_0134 4 None None None 126209236 Common rpsN 30S ribosomal protein S14 APL_1772 208 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 126207526 Common - hypothetical protein APL_0038 19 COG3102 COG3102, Uncharacterized protein conserved in bacteria Function unknown 126209010 Common hcp hydroxylamine reductase APL_1546 76 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 126209029 Common - putative gluconolactonase APL_1565 46 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 126207934 Common mglB D-galactose-binding periplasmic protein precursor APL_0450 76 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 126208420 Common greA transcription elongation factor GreA APL_0944 204 COG0782 GreA, Transcription elongation factor Transcription 126207548 Common - putative N6-adenine-specific DNA methylase APL_0060 153 COG0116 COG0116, Predicted N6-adenine-specific DNA methylase DNA replication, recombination, and repair 126207582 Common engB GTPase EngB APL_0094 179 COG0218 COG0218, Predicted GTPase General function prediction only 126207730 Common argC N-acetyl-gamma-glutamyl-phosphate reductase APL_0242 212 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 126209496 Common hemK HemK-like protein APL_2042 208 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 126207720 Common - hypothetical protein APL_0232 129 COG1678 COG1678, Putative transcriptional regulator Transcription 126207696 Common - putative transposase-like protein APL_0208 115 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 126208756 Common - hypothetical protein APL_1290 93 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 126208455 Common - hypothetical protein APL_0981 8 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 126208606 Common amiB putative N-acetylmuramoyl-L-alanine amidase AmiB precursor APL_1136 175 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 126208194 Common - ABC transport system periplasmic protein APL_0714 62 COG4607 CeuA, ABC-type enterochelin transport system, periplasmic component Inorganic ion transport and metabolism 126207569 Common dhaM PTS-dependent dihydroxyacetone kinase, phosphotransferase subunit DhaM APL_0081 42 COG3412 COG3412, Uncharacterized protein conserved in bacteria Function unknown 126207501 Common murE UDP-N-acetylmuramyl-tripeptide synthetase APL_0013 213 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 126207705 Common - hypothetical protein APL_0217 18 None None None 126209397 Common rnpA ribonuclease P APL_1939 56 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 126208996 Common dcuB anaerobic C4-dicarboxylate transporter APL_1532 36 COG2704 DcuB, Anaerobic C4-dicarboxylate transporter General function prediction only 126207647 Common hcaT putative 3-phenylpropionic acid transporter APL_0159 73 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 126209433 Common trmA tRNA (uracil-5-)-methyltransferase APL_1979 171 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 126209405 Common nhaA Na(+)/H(+) antiporter 1 (Sodium/proton antiporter 1) APL_1947 106 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 126207902 Common - hypothetical protein APL_0418 95 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 126207882 Common upp uracil phosphoribosyltransferase APL_0398 165 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 126209349 Common fabA 3-hydroxydecanoyl-(acyl carrier protein) dehydratase APL_1889 81 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 126207991 Common - hypothetical protein APL_0507 4 None None None 126209463 Common pdxH pyridoxamine 5'-phosphate oxidase APL_2009 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 126208404 Common hscB co-chaperone HscB APL_0928 55 COG1076 DjlA, DnaJ-domain-containing proteins 1 Posttranslational modification, protein turnover, chaperones 126209449 Common ispB octaprenyl-diphosphate synthase APL_1995 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 126208574 Pathogen - hypothetical protein APL_1102 1 None None None 126208127 Common ackA acetate kinase APL_0645 161 COG0282 ackA, Acetate kinase Energy production and conversion 126208679 Common - hypothetical protein APL_1211 72 COG1801 COG1801, Uncharacterized conserved protein Function unknown 126208159 Common glnS glutaminyl-tRNA synthetase APL_0679 239 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 126207715 Common - hypothetical protein APL_0227 4 None None None 126208012 Common - putative transporter APL_0528 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 126209308 Common cysT Sulfate transport system permease protein cysT APL_1846 238 COG0555 CysU, ABC-type sulfate transport system, permease component Posttranslational modification, protein turnover, chaperones 126207891 Common lpxA UDP-N-acetylglucosamine acyltransferase APL_0407 173 COG1043 LpxA, Acyl- acyl carrier protein 126209134 Common rbsA D-ribose transporter ATP binding protein APL_1670 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 126208063 Common mukB cell division protein MukB APL_0581 49 COG3096 MukB, Uncharacterized protein involved in chromosome partitioning Cell division and chromosome partitioning 126208473 Pathogen - hypothetical protein APL_0999 1 None None None 126208931 Common rfbD putative UDP-galactopyranose mutase APL_1467 59 COG0562 Glf, UDP-galactopyranose mutase Cell envelope biogenesis, outer membrane 126208558 Common ompW outer membrane protein W precursor APL_1086 67 COG3047 OmpW, Outer membrane protein W Cell envelope biogenesis, outer membrane 126207713 Common rplT 50S ribosomal protein L20 APL_0225 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 126207831 Common glgX glycogen operon protein GlgX APL_0347 163 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 126208866 Common rfaC ADP-heptose:LPS heptosyl transferase I APL_1402 84 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 126208469 Common galK galactokinase APL_0995 91 COG0153 GalK, Galactokinase Carbohydrate transport and metabolism 126207942 Common dsbC thiol:disulfide interchange protein DsbC precursor APL_0458 60 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 126208625 Common metE 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase APL_1155 142 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 126209380 Common - site-specific recombinase APL_1920 23 COG4389 COG4389, Site-specific recombinase DNA replication, recombination, and repair 126209005 Common tilS tRNA(Ile)-lysidine synthase APL_1541 211 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 126209173 Common - hypothetical protein APL_1709 9 None None None 126208933 Common - glycosyl transferase, family 2 APL_1469 39 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 126208906 Common apxID RTX-I toxin secretion component APL_1442 119 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 126207844 Common impA hypothetical protein APL_0360 24 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 126208812 Common - dsDNA-mimic protein APL_1348 18 COG3099 COG3099, Uncharacterized protein conserved in bacteria Function unknown 126207596 Common iclR putative HTH-type transcriptional regulator APL_0108 123 COG1414 IclR, Transcriptional regulator Transcription 126208302 Common cydC cysteine/glutathione ABC transporter membrane/ATP-binding component APL_0826 249 COG4987 CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 126207570 Common dhaL dihydroxyacetone kinase ADP-binding subunit APL_0082 76 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 126208638 Common priB primosomal replication protein N APL_1170 24 COG2965 PriB, Primosomal replication protein N DNA replication, recombination, and repair 126208004 Common - hypothetical protein APL_0520 13 None None None 126207589 Common nrfB cytochrome c-type protein NrfB APL_0101 21 None None None 126209018 Common wecA putative undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase APL_1554 167 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 126209476 Common - Transposase IS200-like protein APL_2022 30 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 126208512 Common - hypothetical protein APL_1038 73 COG1238 COG1238, Predicted membrane protein Function unknown 126209482 Common hisI Histidine biosynthesis bifunctional protein hisIE APL_2028 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 126208527 Common fabB 3-oxoacyl-(acyl carrier protein) synthase I APL_1055 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 126207967 Common - nitroreductase A APL_0483 98 COG0778 NfnB, Nitroreductase Energy production and conversion 126208236 Common - hypothetical protein APL_0758 29 COG1380 COG1380, Putative effector of murein hydrolase LrgA General function prediction only 126209042 Common kdsA 2-dehydro-3-deoxyphosphooctonate aldolase APL_1578 186 COG2877 KdsA, 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase Cell envelope biogenesis, outer membrane 126208976 Common tufB elongation factor Tu APL_1512 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 126208036 Pathogen rcpB rough colony protein B APL_0554 3 None None None 126208506 Common priA primosome assembly protein PriA APL_1032 213 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 126209086 Common cbiM cobalt transport protein CbiM APL_1622 21 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 126208221 Common cmkA cytidylate kinase APL_0741 206 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 126208885 Common ompA outer membrane protein P5 precursor APL_1421 109 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 126208791 Common hypB hydrogenase nickel incorporation protein HypB APL_1327 118 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 126207915 Common - hypothetical protein APL_0431 181 COG1496 COG1496, Uncharacterized conserved protein Function unknown 126208911 Common afuB Ferric transport system permease protein fbpB APL_1447 217 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 126208314 Common - hypothetical ABC transporter ATP-binding protein APL_0838 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 126209402 Common - phosphate-starvation-inducible protein PsiE APL_1944 20 COG3223 COG3223, Predicted membrane protein Function unknown 126208287 Common - hypothetical protein APL_0811 40 COG1944 COG1944, Uncharacterized conserved protein Function unknown 126208646 Common - putative integral membrane sulfate transporter APL_1178 168 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 126209032 Pathogen tbpB transferrin-binding protein APL_1568 3 None None None 126209437 Common - hypothetical protein APL_1983 27 COG3165 COG3165, Uncharacterized protein conserved in bacteria Function unknown 126209089 Common apuR putative LysR-type transcriptional regulator APL_1625 100 COG0583 LysR, Transcriptional regulator Transcription 126207750 Common modA molybdate-binding periplasmic protein precursor APL_0262 157 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 126208207 Common ilvI acetolactate synthase 3 catalytic subunit APL_0727 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 126208772 Pathogen - hypothetical protein APL_1306 2 None None None 126209119 Common gidA tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA APL_1655 192 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 126208245 Common - hypothetical symporter APL_0767 146 COG3633 SstT, Na+/serine symporter Amino acid transport and metabolism 126208940 Common tyrS tyrosyl-tRNA synthetase APL_1476 244 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126208499 Common lsgF putative glycosyl transferase APL_1025 96 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 126207562 Common recR recombination protein RecR APL_0074 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 126207613 Common - hypothetical protein APL_0125 5 COG5633 COG5633, Predicted periplasmic lipoprotein General function prediction only 126208947 Common - hypothetical protein APL_1483 5 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 126209020 Common - putative transport system permease protein APL_1556 10 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 126208152 Common - hypothetical protein APL_0672 12 COG3663 Mug, G:T/U mismatch-specific DNA glycosylase DNA replication, recombination, and repair 126209008 Common - putative enterobacterial common antigen polymerase APL_1544 13 None None None 126209396 Common rpmH 50S ribosomal protein L34 APL_1938 191 COG0230 RpmH, Ribosomal protein L34 Translation, ribosomal structure and biogenesis 126207852 Common potD2 spermidine/putrescine-binding periplasmic protein 1 precursor APL_0368 138 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 126208385 Common plpB outer membrane lipoprotein 2 precursor APL_0909 100 COG1464 NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen Inorganic ion transport and metabolism 126208280 Common - hypothetical protein APL_0804 71 COG1368 MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily Cell envelope biogenesis, outer membrane 126209135 Common rbsC ribose ABC transporter permease protein APL_1671 112 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 126209422 Common dut deoxyuridine 5'-triphosphate nucleotidohydrolase APL_1968 181 COG0756 Dut, dUTPase Nucleotide transport and metabolism 126208895 Common napF ferredoxin-type protein NapF APL_1431 56 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 126209284 Common rpmJ 50S ribosomal protein L36 APL_1822 65 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 126207811 Common selD selenide, water dikinase APL_0327 139 COG0709 SelD, Selenophosphate synthase Amino acid transport and metabolism 126208323 Common - coproporphyrinogen III oxidase APL_0847 205 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 126208084 Common - hypothetical protein APL_0602 85 COG3022 COG3022, Uncharacterized protein conserved in bacteria Function unknown 126207686 Pathogen - hypothetical protein APL_0198 2 None None None 126208431 Common apxIIB leukotoxin translocation ATP-binding protein LktB (apxIIB) APL_0955 26 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 126208794 Common hypF carbamoyltransferase HypF APL_1330 110 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 126209220 Common nagA N-acetylglucosamine-6-phosphate deacetylase APL_1756 119 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 126208972 Common - putative Rhodanese-related sulfurtransferase APL_1508 82 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 126209294 Common - putative sulfite oxidase subunit YedY APL_1832 120 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 126208360 Common proB gamma-glutamyl kinase APL_0884 193 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 126208106 Common glpX fructose 1,6-bisphosphatase II APL_0624 112 COG1494 GlpX, Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins Carbohydrate transport and metabolism 126208841 Common oadB oxaloacetate decarboxylase beta chain APL_1377 56 COG1883 OadB, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit Energy production and conversion 126207602 Common hupA DNA-binding protein HU APL_0114 214 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 126207754 Common apt adenine phosphoribosyltransferase APL_0266 191 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 126208496 Common - putative transcriptional regulator APL_1022 97 COG2186 FadR, Transcriptional regulators Transcription 126209353 Common gph phosphoglycolate phosphatase APL_1893 207 COG0546 Gph, Predicted phosphatases General function prediction only 126207909 Common purF amidophosphoribosyltransferase APL_0425 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 126208446 Common ispZ intracellular septation protein A APL_0972 90 COG2917 COG2917, Intracellular septation protein A Cell division and chromosome partitioning 126208515 Common - hypothetical protein APL_1041 49 COG2431 COG2431, Predicted membrane protein Function unknown 126209421 Common slmA nucleoid occlusion protein APL_1967 67 COG1309 AcrR, Transcriptional regulator Transcription 126208250 Common aceF dihydrolipoamide acetyltransferase APL_0772 201 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 126207768 Common potA putrescine/spermidine ABC transporter ATPase protein APL_0280 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 126208864 Common rpsG 30S ribosomal protein S7 APL_1400 237 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 126208040 Pathogen flp2 minor fimbrial protein APL_0558 1 COG3847 Flp, Flp pilus assembly protein, pilin Flp Intracellular trafficking and secretion 126208917 Common rpiA ribose-5-phosphate isomerase A APL_1453 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 126207903 Common lgtF UDP-glucose--lipooligosaccharide glucosyltransferase APL_0419 133 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 126208703 Common malE maltose ABC transporter periplasmic protein APL_1237 84 COG2182 MalE, Maltose-binding periplasmic proteins/domains Carbohydrate transport and metabolism 126209212 Common - Outer membrane lipoprotein A precursor APL_1748 9 None None None 126208376 Common lpxL lipid A biosynthesis lauroyl acyltransferase APL_0900 83 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 126208393 Common - transposase APL_0917 36 None None None 126208898 Common - hypothetical protein APL_1434 20 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 126208171 Common moaC molybdenum cofactor biosynthesis protein C APL_0691 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 126208597 Common - predicted Na+/alanine symporter APL_1127 115 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 126207595 Common putP sodium/proline symporter APL_0107 186 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 126209204 Common - hypothetical protein APL_1740 72 COG2924 COG2924, Uncharacterized protein conserved in bacteria Function unknown 126207839 Common proP bicyclomycin/multidrug efflux system APL_0355 184 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 126208984 Common ispH 4-hydroxy-3-methylbut-2-enyl diphosphate reductase APL_1520 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 126208617 Common trpG para-aminobenzoate synthase component II APL_1147 230 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 126208331 Common hbpA heme-binding protein A precursor APL_0855 213 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 126208910 Common afuA ABC-type Fe3+ transport system, periplasmic component APL_1446 108 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 126209470 Common - Ferrioxamine B receptor precursor APL_2016 110 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 126208368 Common fdxG formate dehydrogenase, nitrate-inducible, major subunit APL_0892 162 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 126209162 Common ulaD 3-keto-L-gulonate-6-phosphate decarboxylase APL_1698 53 COG0269 SgbH, 3-hexulose-6-phosphate synthase and related proteins Carbohydrate transport and metabolism 126208852 Common - predicted ABC-transport permease APL_1388 62 COG4137 COG4137, ABC-type uncharacterized transport system, permease component General function prediction only 126209087 Common cbiL putative cytoplasmic membrane protein CbiL APL_1623 3 None None None 126208569 Common queC queuosine biosynthesis protein QueC APL_1097 172 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 126208528 Common - transposase APL_1056 14 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 126209358 Common ap2029 hypothetical protein APL_1898 125 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 126208346 Common - putative C4-dicarboxylate transporter APL_0870 24 COG3069 DcuC, C4-dicarboxylate transporter Energy production and conversion 126209382 Common pgaB Biofilm PGA synthesis lipoprotein PgaB precursor APL_1922 75 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 126207800 Common ampD N-acetyl-anhydromuranmyl-L-alanine amidase APL_0316 107 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 126208559 Common clpB chaperone ClpB APL_1087 220 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 126209254 Common - Protein HI0396 APL_1790 57 COG2850 COG2850, Uncharacterized conserved protein Function unknown 126207641 Common nqrD Na(+)-translocating NADH-quinone reductase subunit D APL_0153 76 COG1347 NqrD, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD Energy production and conversion 126208871 Common psd phosphatidylserine decarboxylase APL_1407 96 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 126207651 Common - anaerobic ribonucleoside triphosphate reductase APL_0163 62 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 126207725 Common - hypothetical protein APL_0237 4 COG4701 COG4701, Uncharacterized protein conserved in bacteria Function unknown 126208051 Common pyrH uridylate kinase APL_0569 230 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 126207697 Common - putative transposase-like protein APL_0209 37 None None None 126208027 Common recO DNA repair protein RecO APL_0545 100 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 126207554 Common dppC dipeptide transport system permease protein DppC APL_0066 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 126208472 Common apxIVA RTX toxin protein APL_0998 91 COG2931 COG2931, RTX toxins and related Ca2+-binding proteins Secondary metabolites biosynthesis, transport, and catabolism 126208224 Common topB2 DNA topoisomerase III APL_0744 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 126209247 Common rpsD 30S ribosomal protein S4 APL_1783 225 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 126209075 Common ureD urease accessory protein UreD APL_1611 54 COG0829 UreH, Urease accessory protein UreH Posttranslational modification, protein turnover, chaperones 126209270 Common - hypothetical protein APL_1806 10 COG2832 COG2832, Uncharacterized protein conserved in bacteria Function unknown 126208777 Common nudE ADP-ribose diphosphatase NudE APL_1313 134 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 126207677 Common dus tRNA-dihydrouridine synthase B APL_0189 211 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 126208320 Common queF 7-cyano-7-deazaguanine reductase APL_0844 93 COG2904 COG2904, Uncharacterized protein conserved in bacteria Function unknown 126208019 Common - putative transcriptional activator APL_0537 74 COG0819 TenA, Putative transcription activator Transcription 126207670 Common dnaQ ribonuclease T APL_0182 80 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 126208730 Common - putative cation transport ATPase APL_1264 87 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 126209223 Common rpsJ 30S ribosomal protein S10 APL_1759 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 126208480 Common - hypothetical protein APL_1006 60 COG2354 COG2354, Uncharacterized protein conserved in bacteria Function unknown 126209113 Common atpH ATP synthase delta chain APL_1649 164 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 126208329 Common - methionine synthase II (cobalamin-independent) APL_0853 43 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 126209264 Common glyQ glycyl-tRNA synthetase subunit alpha APL_1800 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 126208018 Common thiH thiazole biosynthesis protein ThiH APL_0536 57 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 126209076 Common ureG urease accessory protein UreG APL_1612 152 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 126207782 Common cydB cytochrome oxidase subunit 2 APL_0298 155 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 126208113 Common accD acetyl-CoA carboxylase subunit beta APL_0631 219 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 126208047 Common cirA hypothetical ABC transporter ATP-binding protein APL_0565 249 COG4178 COG4178, ABC-type uncharacterized transport system, permease and ATPase components General function prediction only 126208178 Common argA N-acetylglutamate synthase APL_0698 203 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 126209021 Common mviN virulence factor-like MviN APL_1557 191 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 126208785 Common thiP thiamin transporter membrane protein APL_1321 144 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 126208820 Common - putative sodium/calcium exchange protein APL_1356 138 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 126209170 Pathogen - hypothetical protein APL_1706 4 None None None 126207635 Common - ribonucleoside-diphosphate reductase beta chain APL_0147 92 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 126207794 Common moeA molybdopterin biosynthesis protein MoeA APL_0310 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 126208356 Common apfA type 4 prepilin subunit ApfA precursor APL_0880 4 COG4969 PilA, Tfp pilus assembly protein, major pilin PilA Cell motility and secretion / Intracellular trafficking and secretion 126207739 Common sodA manganese superoxide dismutase APL_0251 207 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 126207737 Common thrB homoserine kinase APL_0249 133 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 126207499 Common ftsL cell division protein FtsL APL_0011 12 COG3116 FtsL, Cell division protein Cell division and chromosome partitioning 126207817 Common visC putative monooxygenase family protein APL_0333 128 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 126208135 Common uspA universal stress protein A-like protein APL_0655 31 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 126208257 Common - hypothetical protein APL_0779 84 COG1346 LrgB, Putative effector of murein hydrolase Cell envelope biogenesis, outer membrane 126208313 Common - hypothetical protein APL_0837 64 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 126207767 Common rep ATP-dependent DNA helicase APL_0279 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 126207868 Common ribA riboflavin biosynthesis protein APL_0384 232 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 126208522 Common hugZ heme utilization protein APL_1048 21 COG0748 HugZ, Putative heme iron utilization protein Inorganic ion transport and metabolism 126208878 Common mqo malate:quinone oxidoreductase APL_1414 58 COG0579 COG0579, Predicted dehydrogenase General function prediction only 126208956 Common - hypothetical protein APL_1492 39 COG3830 COG3830, ACT domain-containing protein Signal transduction mechanisms 126209238 Common rplF 50S ribosomal protein L6 APL_1774 235 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 126207646 Common trmU tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase APL_0158 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 126207662 Common tbpA thiamine-binding periplasmic protein precursor APL_0174 56 COG4143 TbpA, ABC-type thiamine transport system, periplasmic component Coenzyme metabolism 126209133 Common rbsD high affinity ribose transport protein RbsD APL_1669 46 COG1869 RbsD, ABC-type ribose transport system, auxiliary component Carbohydrate transport and metabolism 126208142 Common aspC aromatic amino acid aminotransferase APL_0662 71 COG1448 TyrB, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 126208573 Common pepA putative cytosol aminopeptidase APL_1101 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 126208273 Common tyrR transcriptional regulatory protein TyrR APL_0797 172 COG3283 TyrR, Transcriptional regulator of aromatic amino acids metabolism Transcription / Amino acid transport and metabolism 126209298 Pathogen - hypothetical protein APL_1836 1 None None None 126209293 Common - RNA polymerase sigma factor APL_1831 87 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 126208078 Common tyrP-A tyrosine-specific transport protein 1 APL_0596 41 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 126208748 Common dnaQ DNA polymerase III subunit epsilon APL_1282 188 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 126207558 Common - hypothetical protein APL_0070 3 None None None 126207721 Common - hypothetical protein APL_0233 203 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 126207982 Common - hypothetical protein APL_0498 8 None None None 126209430 Common yedF hypothetical protein APL_1976 33 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 126208309 Common - hypothetical protein APL_0833 83 COG1279 COG1279, Lysine efflux permease General function prediction only 126207774 Common gyrA DNA gyrase subunit A APL_0286 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 126208296 Common - putative membrane-associated protein APL_0820 157 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 126208709 Common gor glutathione reductase APL_1243 245 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 126207516 Common - ABC transporter permease protein APL_0028 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 126207840 Pathogen - hypothetical protein APL_0356 2 None None None 126207976 Pathogen - hypothetical protein APL_0492 1 None None None 126208916 Common serA D-3-phosphoglycerate dehydrogenase APL_1452 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 126208726 Common pstC phosphate transport system permease protein PstC APL_1260 225 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 126209110 Common atpD F0F1 ATP synthase subunit beta APL_1646 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 126208082 Common rplM 50S ribosomal protein L13 APL_0600 245 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 126208229 Common menE O-succinylbenzoic acid--CoA ligase APL_0751 215 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 126207632 Common - predicted ATP-dependent endonuclease of the OLD family APL_0144 31 COG3593 COG3593, Predicted ATP-dependent endonuclease of the OLD family DNA replication, recombination, and repair 126208596 Common - putative micrococcal nuclease (thermonuclease)-like protein APL_1126 67 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 126209321 Common - Probable NADH-dependent butanol dehydrogenase 1 APL_1859 168 COG1979 COG1979, Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family Energy production and conversion 126208222 Common degS protease DegS precursor APL_0742 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 126208182 Common serC phosphoserine aminotransferase APL_0702 119 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 126209347 Common pulJ hypothetical protein APL_1887 3 COG4795 PulJ, Type II secretory pathway, component PulJ Intracellular trafficking and secretion 126207887 Common engA GTP-binding protein EngA APL_0403 240 COG1160 COG1160, Predicted GTPases General function prediction only 126207515 Common - nickel transport system permease protein APL_0027 190 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 126207941 Common - hypothetical metalloprotease APL_0457 188 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 126209267 Common glyS glycyl-tRNA synthetase subunit beta APL_1803 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 126208097 Common mlc putative transcriptional repressor of carbohydrate metabolism APL_0615 37 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 126209225 Common rplD 50S ribosomal protein L4 APL_1761 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 126208745 Common clpX ATP-dependent protease ATP-binding subunit APL_1279 239 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 126207955 Common - hypothetical protein APL_0471 6 None None None 126209046 Common cpxD capsule polysaccharide export protein APL_1582 64 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 126208279 Common ispF 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase APL_0803 189 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 126209031 Common tbpA transferrin-binding protein 1 Tbp1 APL_1567 33 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 126207981 Common - hypothetical protein APL_0497 9 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 126207819 Common ptsN PTS system, nitrogen regulatory IIA-like protein APL_0335 115 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 126208419 Common - N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase APL_0943 213 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 126208133 Common csrA carbon storage regulator CsrA APL_0653 84 COG1551 CsrA, Carbon storage regulator (could also regulate swarming and quorum sensing) Signal transduction mechanisms 126208882 Common mglC beta-methylgalactoside transporter inner membrane component APL_1418 110 COG4211 MglC, ABC-type glucose/galactose transport system, permease component Carbohydrate transport and metabolism 126208130 Common - hypothetical protein APL_0650 4 COG3923 PriC, Primosomal replication protein N'' DNA replication, recombination, and repair 126208781 Common arcB ornithine carbamoyltransferase APL_1317 239 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 126208013 Common - putative ABC transporter permease protein APL_0531 138 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 126208509 Common pflA pyruvate formate lyase-activating enzyme 1 APL_1035 102 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 126208585 Common eno phosphopyruvate hydratase APL_1113 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 126208959 Common - putative transcriptional regulator APL_1495 22 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 126207912 Common smpA small protein A APL_0428 64 COG2913 SmpA, Small protein A (tmRNA-binding) Translation, ribosomal structure and biogenesis 126207953 Common trpB tryptophan synthase subunit beta APL_0469 225 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 126208960 Common - hypothetical protein APL_1496 21 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 126207523 Common - putative protein-S-isoprenylcysteine methyltransferase APL_0035 46 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 126207841 Common - hypothetical protein APL_0357 14 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 126208283 Common ispA geranyltranstransferase APL_0807 242 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 126208311 Common dcd deoxycytidine triphosphate deaminase APL_0835 154 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 126208757 Common - hypothetical protein APL_1291 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 126209077 Common ureF urease accessory protein UreF APL_1613 84 COG0830 UreF, Urease accessory protein UreF Posttranslational modification, protein turnover, chaperones 126207712 Common rpmI 50S ribosomal protein L35 APL_0224 30 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 126209313 Common murB UDP-N-acetylenolpyruvoylglucosamine reductase APL_1851 198 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 126207668 Common - hypothetical protein APL_0180 4 None None None 126209272 Common lpxH UDP-2,3-diacylglucosamine hydrolase APL_1808 82 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 126209286 Common menB naphthoate synthase APL_1824 175 COG0447 MenB, Dihydroxynaphthoic acid synthase Coenzyme metabolism 126208334 Common mnmC 5-methylaminomethyl-2-thiouridine methyltransferase APL_0858 84 COG4121 COG4121, Uncharacterized conserved protein Function unknown 126209429 Common ddc L-2,4-diaminobutyrate decarboxylase APL_1975 106 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 126208029 Common tadF tight adherence protein F APL_0547 5 None None None 126209107 Common - hypothetical protein APL_1643 35 COG2923 DsrF, Uncharacterized protein involved in the oxidation of intracellular sulfur Inorganic ion transport and metabolism 126207581 Common - hypothetical protein APL_0093 23 COG3076 COG3076, Uncharacterized protein conserved in bacteria Function unknown 126207848 Common ssa1 serotype-specific antigen 1 precursor APL_0364 70 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 126208686 Common fur ferric uptake regulation protein APL_1218 194 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 126209074 Common - hypothetical protein APL_1610 14 COG1359 COG1359, Uncharacterized conserved protein Function unknown 126208806 Common folB dihydroneopterin aldolase APL_1342 108 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 126207565 Common exbD2 biopolymer transport protein ExbD2 APL_0077 125 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 126208325 Common - inner membrane ABC transporter permease APL_0849 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 126209237 Common rpsH 30S ribosomal protein S8 APL_1773 245 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 126208780 Common dcuB2 anaerobic C4-dicarboxylate transporter APL_1316 36 COG2704 DcuB, Anaerobic C4-dicarboxylate transporter General function prediction only 126208139 Common purE phosphoribosylaminoimidazole carboxylase catalytic subunit APL_0659 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 126207654 Common rnfB electron transport complex protein RnfB APL_0166 114 COG2878 COG2878, Predicted NADH:ubiquinone oxidoreductase, subunit RnfB Energy production and conversion 126208153 Common sbcB exonuclease I APL_0673 51 COG2925 SbcB, Exonuclease I DNA replication, recombination, and repair 126208340 Common - hypothetical protein APL_0864 4 None None None 126208624 Common - putative zinc protease APL_1154 156 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 126208174 Common - hypothetical protein APL_0694 203 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 126209215 Common - hypothetical protein APL_1751 10 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 126207836 Common metG methionyl-tRNA synthetase APL_0352 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126207532 Common ileS isoleucyl-tRNA synthetase APL_0044 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126208297 Common gyrB DNA gyrase subunit B APL_0821 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 126208688 Common - LexA regulated protein APL_1220 21 None None None 126208843 Common ccp cytochrome c peroxidase APL_1379 93 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 126207770 Common potC spermidine/putrescine ABC transporter membrane protein APL_0282 170 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 126208378 Common truA tRNA pseudouridine synthase A APL_0902 235 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 126208630 Common - hypothetical protein APL_1162 56 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 126209186 Common - hypothetical protein APL_1722 5 None None None 126209102 Common dsbA_2 thiol disulfide oxidoreductase APL_1638 29 None None None 126208238 Common apaH diadenosine tetraphosphatase APL_0760 92 COG0639 ApaH, Diadenosine tetraphosphatase and related serine/threonine protein phosphatases Signal transduction mechanisms 126208857 Common ptnD mannose-specific PTS system protein IID APL_1393 41 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 126208990 Common frdD fumarate reductase subunit D APL_1526 20 COG3080 FrdD, Fumarate reductase subunit D Energy production and conversion 126208865 Common rpsL 30S ribosomal protein S12 APL_1401 240 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 126208614 Common - hypothetical protein APL_1144 13 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 126207762 Common - hypothetical protein APL_0274 116 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 126209436 Common ubiE Ubiquinone/menaquinone biosynthesis methyltransferase ubiE APL_1982 223 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 126208043 Pathogen - hypothetical protein APL_0561 2 None None None 126208369 Common fdxG formate dehydrogenase, nitrate-inducible, major subunit APL_0893 183 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 126209357 Common nudH dinucleoside polyphosphate hydrolase APL_1897 113 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 126207809 Common - hypothetical protein APL_0325 123 COG0679 COG0679, Predicted permeases General function prediction only 126208681 Common - hypothetical protein APL_1213 183 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 126208764 Common adk adenylate kinase APL_1298 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 126208576 Common - hypothetical protein APL_1104 126 COG0795 COG0795, Predicted permeases General function prediction only 126208100 Common ftsK DNA translocase FtsK APL_0618 197 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 126208493 Common kdgK 2-dehydro-3-deoxygluconokinase APL_1019 184 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 126209373 Common pepO neutral endopeptidase APL_1913 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 126208454 Common lbgA putative LPS biosynthesis protein APL_0980 24 COG3306 COG3306, Glycosyltransferase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 126208146 Common - hypothetical protein APL_0666 13 COG4456 VagC, Virulence-associated protein and related proteins Function unknown 126209361 Common rraA ribonuclease activity regulator protein RraA APL_1901 81 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 126207988 Common - hypothetical protein APL_0504 5 None None None 126209163 Common ulaC Ascorbate-specific phosphotransferase enzyme IIA component APL_1699 46 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 126208269 Common sapD peptide transport system ATP-binding protein SapD APL_0793 249 COG4170 SapD, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126208267 Common - dioxygenase APL_0789 125 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 126209154 Common - inner membrane protein APL_1690 16 COG3477 COG3477, Predicted periplasmic/secreted protein Function unknown 126207606 Common cspC cold shock-like protein CspC APL_0118 179 COG1278 CspC, Cold shock proteins Transcription 126209352 Common trpS Tryptophanyl-tRNA synthetase APL_1892 227 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126207742 Common pepD aminoacyl-histidine dipeptidase APL_0254 58 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 126208217 Common - hypothetical protein APL_0737 71 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 126208160 Common - hypothetical transport protein APL_0680 183 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 126207674 Common - ADP-heptose:LPS heptosyltransferase I APL_0186 112 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 126207536 Common arcA DNA-binding response regulator in two-component regulatory system with ArcB or CpxA APL_0048 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126208986 Common - hypothetical protein APL_1522 16 COG2910 COG2910, Putative NADH-flavin reductase General function prediction only 126208706 Common malQ 4-alpha-glucanotransferase APL_1240 120 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 126208978 Common dsbE thiol:disulfide interchange protein DsbE APL_1514 117 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 126208538 Common yajC preprotein translocase subunit YajC APL_1066 171 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 126207604 Common - hypothetical protein APL_0116 4 None None None 126208403 Common - hypothetical protein APL_0927 62 COG3238 COG3238, Uncharacterized protein conserved in bacteria Function unknown 126208560 Common - hypothetical protein APL_1088 125 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 126208214 Common - hypothetical protein APL_0734 18 COG3787 COG3787, Uncharacterized protein conserved in bacteria Function unknown 126209146 Common purL phosphoribosylformylglycinamidine synthase APL_1682 232 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 126208421 Common dacB D-alanyl-D-alanine carboxypeptidase/endopeptidase APL_0945 104 COG2027 DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) Cell envelope biogenesis, outer membrane 126208256 Common msbA lipid transporter ATP-binding/permease protein APL_0778 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 126208073 Common pgm phosphoglucomutase/phosphomannomutase APL_0591 241 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 126209297 Common glpT Glycerol-3-phosphate transporter APL_1835 44 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 126208977 Common coaA pantothenate kinase APL_1513 76 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 126208700 Common - maltose regulon periplasmic protein APL_1234 17 None None None 126207786 Common tolA cell envelope integrity inner membrane protein TolA APL_0302 8 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 126208521 Common hgbA hemoglobin-binding protein A precursor APL_1047 66 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 126208435 Common - hemagglutinin/hemolysin-like protein APL_0959 38 COG3210 FhaB, Large exoproteins involved in heme utilization or adhesion Intracellular trafficking and secretion 126207491 Common recF recombination protein F APL_0003 166 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 126207969 Common - hypothetical protein APL_0485 64 COG1434 COG1434, Uncharacterized conserved protein Function unknown 126208399 Common - hypothetical protein APL_0923 43 COG2975 COG2975, Uncharacterized protein conserved in bacteria Function unknown 126208575 Common - hypothetical protein APL_1103 105 COG0795 COG0795, Predicted permeases General function prediction only 126207498 Common mraW S-adenosyl-methyltransferase MraW APL_0010 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 126208235 Common rnb exoribonuclease II APL_0757 191 COG4776 Rnb, Exoribonuclease II Transcription 126209174 Common rfaD ADP-L-glycero-D-mannoheptose-6-epimerase APL_1710 224 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 126209499 Common sseA Probable thiosulfate sulfurtransferase APL_2045 133 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 126207930 Common ykgE putative dehydrogenase subunit APL_0446 157 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 126208248 Common - hypothetical protein APL_0770 5 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 126207977 Pathogen - hypothetical protein APL_0493 2 None None None 126209034 Common exbB biopolymer transport ExbB protein APL_1570 147 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 126207960 Common mtgA monofunctional biosynthetic peptidoglycan transglycosylase APL_0476 198 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 126209147 Common fucR L-fucose operon activator APL_1683 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 126208031 Common tadD tight adherence protein D APL_0549 7 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 126209461 Common rimI ribosomal-protein-alanine N-acetyltransferase APL_2007 195 COG0456 RimI, Acetyltransferases General function prediction only 126209440 Common tatB sec-independent translocase APL_1986 22 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 126209015 Common wecC UDP-N-acetyl-D-mannosamine dehydrogenase APL_1551 206 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 126208997 Common crcB camphor resistance-like protein CrcB APL_1533 28 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 126207812 Common mutT putative NTP pyrophosphohydrolase (MutT/Nudix family) APL_0328 51 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 126208498 Common - peptide methionine sulfoxide reductase MsrA APL_1024 205 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 126208952 Common plsC 1-acyl-sn-glycerol-3-phosphate acyltransferase APL_1488 138 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 126208462 Common hktE catalase APL_0988 127 COG0753 KatE, Catalase Inorganic ion transport and metabolism 126209431 Common yedE predicted inner membrane protein APL_1977 40 COG2391 COG2391, Predicted transporter component General function prediction only 126207500 Common ftsI peptidoglycan synthetase FtsI APL_0012 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 126208204 Common - hypothetical protein APL_0724 18 None None None 126208303 Common cydD cysteine/glutathione ABC transporter membrane/ATP-binding component APL_0827 247 COG4988 CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 126208198 Common - hypothetical protein APL_0718 37 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 126208923 Common - hypothetical protein APL_1459 94 COG1720 COG1720, Uncharacterized conserved protein Function unknown 126208028 Common tadG tight adherence protein G APL_0546 6 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 126208191 Common - hypothetical protein APL_0711 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 126209009 Common wecF 4-alpha-L-fucosyltransferase APL_1545 17 None None None 126208632 Common trpG anthranilate synthase component II APL_1164 229 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 126209435 Common corA magnesium/nickel/cobalt transporter CorA APL_1981 156 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 126209468 Common - ABC-type Fe3+-hydroxamate transport system, periplasmic component; FhuD APL_2014 39 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 126209116 Common atpB F0F1 ATP synthase subunit A APL_1652 207 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 126209268 Common - hypothetical protein APL_1804 4 None None None 126208611 Common - hypothetical protein APL_1141 17 COG3097 COG3097, Uncharacterized protein conserved in bacteria Function unknown 126209475 Common hisC histidinol-phosphate aminotransferase APL_2021 237 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 126208057 Common deaD cold-shock DEAD box protein A-like protein APL_0575 235 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 126208644 Common ispG 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase APL_1176 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 126208112 Common mazG predicted pyrophosphatase APL_0630 155 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 126207612 Common - hypothetical protein APL_0124 14 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 126207584 Common - zinc transporter family protein ZIP APL_0096 109 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 126207999 Common - hypothetical protein APL_0515 2 None None None 126207918 Common gapA glyceraldehyde-3-phosphate dehydrogenase APL_0434 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 126207905 Common waaQ heptosyltransferase APL_0421 42 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 126208905 Common - hypothetical protein APL_1441 5 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 126208060 Common parC DNA topoisomerase IV subunit A APL_0578 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 126208484 Common hemC porphobilinogen deaminase APL_1010 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 126208798 Common hyaB hydrogenase 2 large subunit APL_1334 105 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 126207872 Common pepB aminopeptidase B APL_0388 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 126209316 Common pqiA hypothetical protein APL_1854 51 COG2995 PqiA, Uncharacterized paraquat-inducible protein A Function unknown 126208969 Common holC DNA polymerase III subunit chi APL_1505 58 COG2927 HolC, DNA polymerase III, chi subunit DNA replication, recombination, and repair 126208659 Common namA NADPH dehydrogenase APL_1191 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 126209041 Common kdsB 3-deoxy-manno-octulosonate cytidylyltransferase APL_1577 142 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 126208318 Common pntA NAD(P) transhydrogenase subunit alpha APL_0842 165 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 126207990 Pathogen - hypothetical protein APL_0506 2 None None None 126208371 Common fdnI formate dehydrogenase, cytochrome b556 subunit APL_0895 70 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 126208740 Common - hypothetical protein APL_1274 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 126209239 Common rplR 50S ribosomal protein L18 APL_1775 217 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 126207731 Common argB acetylglutamate kinase (AGK) APL_0243 211 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 126208643 Common hisS histidyl-tRNA synthetase APL_1175 248 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126209255 Common - putative periplasmic iron/siderophore binding protein APL_1791 111 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 126208516 Common menF menaquinone-specific isochorismate synthase APL_1042 223 COG1169 MenF, Isochorismate synthase Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism 126209386 Common truD tRNA pseudouridine synthase D APL_1926 86 COG0585 COG0585, Uncharacterized conserved protein Function unknown 126209417 Common - hypothetical protein APL_1963 120 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 126208936 Common rfbB1 dTDP-glucose 4,6-dehydratase APL_1472 227 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 126209139 Common dmsB anaerobic dimethyl sulfoxide reductase chain B APL_1675 161 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 126209108 Common - hypothetical protein APL_1644 5 COG2168 DsrH, Uncharacterized conserved protein involved in oxidation of intracellular sulfur Inorganic ion transport and metabolism 126208832 Common ccmE cytochrome c-type biogenesis protein CcmE APL_1368 92 COG2332 CcmE, Cytochrome c-type biogenesis protein CcmE Posttranslational modification, protein turnover, chaperones 126209120 Common - hypothetical protein APL_1656 124 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 126208347 Common pepE peptidase E APL_0871 34 COG3340 PepE, Peptidase E Amino acid transport and metabolism 126208676 Common adhC putative alcohol dehydrogenase class 3 APL_1208 180 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 126207702 Common - hypothetical protein APL_0214 18 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 126208511 Common focA putative formate transporter APL_1037 95 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 126208735 Common - putative ribonuclease APL_1269 42 COG3719 Rna, Ribonuclease I Translation, ribosomal structure and biogenesis 126207724 Pathogen - putative lipoprotein APL_0236 3 COG3015 CutF, Uncharacterized lipoprotein NlpE involved in copper resistance Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism 126208000 Common - hypothetical protein APL_0516 1 None None None 126209392 Common - hypothetical protein APL_1934 18 COG0700 SpmB, Uncharacterized membrane protein Function unknown 126207827 Common fruA PTS system fructose-specific EIIBC component APL_0343 68 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 126208542 Common ftnB ferritin-like protein 2 APL_1070 84 COG1528 Ftn, Ferritin-like protein Inorganic ion transport and metabolism 126208183 Common - hypothetical ATP-dependent helicase APL_0703 175 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 126207547 Common narP nitrate/nitrite response regulator protein APL_0059 219 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 126207514 Common - ABC transporter ATP-binding protein APL_0026 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 126208805 Common - hypothetical protein APL_1341 170 COG0344 COG0344, Predicted membrane protein Function unknown 126209331 Common - hypothetical protein APL_1869 3 None None None 126209443 Common - hypothetical protein APL_1989 21 COG3671 COG3671, Predicted membrane protein Function unknown 126209222 Common - possible DNA transformation protein APL_1758 10 COG3070 TfoX, Regulator of competence-specific genes Transcription 126208030 Common tadE tight adherence protein E APL_0548 6 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 126207862 Common glpQ glycerophosphodiester phosphodiesterase APL_0378 98 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 126209309 Common cysW Sulfate transport system permease protein cysW APL_1847 192 COG4208 CysW, ABC-type sulfate transport system, permease component Inorganic ion transport and metabolism 126208088 Common - hypothetical symporter APL_0606 160 COG1823 COG1823, Predicted Na+/dicarboxylate symporter General function prediction only 126208272 Common sapA peptide transport periplasmic protein SapA precursor APL_0796 170 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 126208501 Common - hypothetical protein APL_1027 5 None None None 126209193 Pathogen - hypothetical protein APL_1729 1 None None None 126208402 Common - hypothetical protein APL_0926 8 None None None 126207628 Common - hypothetical protein APL_0140 39 COG3835 CdaR, Sugar diacid utilization regulator Transcription / Signal transduction mechanisms 126207897 Common cdsA phosphatidate cytidylyltransferase APL_0413 215 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 126208417 Common bioF 8-amino-7-oxononanoate synthase APL_0941 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 126208836 Common ccmA cytochrome c biogenesis ATP-binding export protein CcmA APL_1372 248 COG4133 CcmA, ABC-type transport system involved in cytochrome c biogenesis, ATPase component Posttranslational modification, protein turnover, chaperones 126207884 Common surA peptidyl-prolyl cis-trans isomerase SurA APL_0400 143 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 126209205 Common mltC murein transglycosylase C APL_1741 139 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 126207571 Common dhaK dihydroxyacetone kinase subunit DhaK APL_0083 77 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 126207621 Common cysB transcriptional regulator CysB APL_0133 191 COG0583 LysR, Transcriptional regulator Transcription 126208091 Common pheT phenylalanyl-tRNA synthetase subunit beta APL_0609 238 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 126207833 Common glgA glycogen synthase APL_0349 153 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 126208124 Common mltB membrane-bound lytic murein transglycosylase B APL_0642 103 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 126209002 Common - predicted acetyltransferase APL_1538 43 COG0456 RimI, Acetyltransferases General function prediction only 126208881 Common - hypothetical protein APL_1417 41 COG4125 COG4125, Predicted membrane protein Function unknown 126208337 Common - hypothetical protein APL_0861 31 COG3098 COG3098, Uncharacterized protein conserved in bacteria Function unknown 126208829 Common hly hypothetical protein APL_1365 68 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 126208335 Common trpCF bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase APL_0859 220 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 126208736 Common sprT hypothetical protein APL_1270 26 COG3091 SprT, Uncharacterized protein conserved in bacteria Function unknown 126208014 Common - predicted dinucleotide-utilizing enzyme involved in molybdopterin and thiamine biosynthesis APL_0532 219 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 126208006 Common - phage-related tail assembly protein K APL_0522 13 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 126207983 Common - hypothetical protein APL_0499 20 COG3645 COG3645, Uncharacterized phage-encoded protein Function unknown 126209489 Common sufI Copper-containing nitrite reductase precursor APL_2035 73 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 126208504 Common - hypothetical protein APL_1030 20 COG5039 COG5039, Exopolysaccharide biosynthesis protein Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 126208687 Common fldA flavodoxin FldA APL_1219 73 COG0716 FldA, Flavodoxins Energy production and conversion 126207980 Common - hypothetical protein APL_0496 12 COG1106 COG1106, Predicted ATPases General function prediction only 126208081 Common - hypothetical protein APL_0599 19 COG3105 COG3105, Uncharacterized protein conserved in bacteria Function unknown 126208132 Common manB phosphomannomutase APL_0652 241 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 126208784 Common thiQ thiamine transport ATP-binding protein ThiQ APL_1320 249 COG3840 ThiQ, ABC-type thiamine transport system, ATPase component Coenzyme metabolism 126209390 Common - Outer membrane antigenic lipoprotein B precursor APL_1930 165 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 126209050 Common modF putative molybdenum transport ATP-binding protein ModF APL_1586 249 COG1119 ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA Inorganic ion transport and metabolism 126207911 Common gdhA glutamate dehydrogenase APL_0427 170 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 126208594 Common pfkA 6-phosphofructokinase APL_1124 161 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 126208304 Common - hypothetical protein APL_0828 97 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 126208537 Common - hypothetical protein APL_1065 18 COG3054 COG3054, Predicted transcriptional regulator General function prediction only 126207598 Common - hypothetical protein APL_0110 33 COG3027 COG3027, Uncharacterized protein conserved in bacteria Function unknown 126208255 Common lolB outer membrane lipoprotein LolB APL_0777 30 COG3017 LolB, Outer membrane lipoprotein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 126207566 Common exbB2 biopolymer transport protein ExbB2 APL_0078 21 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 126208363 Common fadI 3-ketoacyl-CoA thiolase APL_0887 167 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 126208887 Common - hypothetical protein APL_1423 70 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 126209202 Common - lactoylglutathione lyase and related lyases APL_1738 49 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 126207784 Common tolQ colicin transport protein TolQ APL_0300 144 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 126207667 Common - hypothetical protein APL_0179 14 None None None 126209192 Common rpoC DNA-directed RNA polymerase subunit beta' APL_1728 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 126208038 Common rcpC flp operon protein C APL_0556 5 None None None 126209319 Common merP MerP APL_1857 11 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 126209404 Common - hypothetical protein APL_1946 63 COG2510 COG2510, Predicted membrane protein Function unknown 126207741 Common recD exodeoxyribonuclease V alpha chain APL_0253 124 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 126208138 Common sspA stringent starvation protein A-like protein APL_0658 104 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 126209176 Common smf Protein smf (DNA-processing chain A) APL_1712 210 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 126209248 Common rpoA DNA-directed RNA polymerase subunit alpha APL_1784 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 126208815 Common artM arginine transporter permease subunit ArtM APL_1351 171 COG4160 ArtM, ABC-type arginine/histidine transport system, permease component Amino acid transport and metabolism 126209045 Common - putative glycosyltransferase APL_1581 25 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 126209322 Common lysR LysR protein APL_1860 138 COG0583 LysR, Transcriptional regulator Transcription 126208707 Common - hypothetical protein APL_1241 109 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 126209044 Common cps5B region 2 capsular polysaccharide biosynthesis protein APL_1580 2 None None None 126208319 Common - hypothetical tRNA/rRNA methyltransferase APL_0843 156 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 126208387 Common metI D-methionine transport system permease protein MetI APL_0911 117 COG2011 AbcD, ABC-type metal ion transport system, permease component Inorganic ion transport and metabolism 126208698 Common malP maltodextrin phosphorylase APL_1232 148 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 126208284 Common - hypothetical protein APL_0808 53 COG3169 COG3169, Uncharacterized protein conserved in bacteria Function unknown 126208494 Common uxaC uronate isomerase APL_1020 51 COG1904 UxaC, Glucuronate isomerase Carbohydrate transport and metabolism 126208746 Common clpP ATP-dependent Clp protease proteolytic subunit APL_1280 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 126209224 Common rplC 50S ribosomal protein L3 APL_1760 239 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 126208861 Common - hypothetical protein APL_1397 6 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 126208789 Common - hypothetical protein APL_1325 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 126207669 Common gloA lactoylglutathione lyase APL_0181 128 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 126208929 Common - hypothetical protein APL_1465 4 None None None 126207956 Pathogen - hypothetical protein APL_0472 2 None None None 126207640 Common nqrC Na(+)-translocating NADH-quinone reductase subunit C APL_0152 46 COG2869 NqrC, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC Energy production and conversion 126208725 Common pstA phosphate transport system permease protein PstA APL_1259 227 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 126209490 Common lolE outer membrane-specific lipoprotein transporter subunit LolE APL_2036 194 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126207761 Common - putative dissimilatory sulfite reductase APL_0273 60 COG2920 DsrC, Dissimilatory sulfite reductase (desulfoviridin), gamma subunit Inorganic ion transport and metabolism 126208230 Common seqA replication initiation regulator SeqA APL_0752 23 COG3057 SeqA, Negative regulator of replication initiationR DNA replication, recombination, and repair 126207886 Common hldE bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase APL_0402 187 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 126209180 Common secE preprotein translocase subunit SecE APL_1716 65 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 126208021 Common thiD phosphomethylpyrimidine kinase APL_0539 211 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 126208278 Common ispD 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase APL_0802 196 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 126207923 Common znuB high-affinity zinc uptake system membrane protein ZnuB APL_0439 192 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 162329624 Common ulaA ascorbate-specific PTS system enzyme IIC/IIB APL_1700 36 COG3037 SgaT, Uncharacterized protein conserved in bacteria Function unknown 126207520 Common yhaH hypothetical protein APL_0032 42 COG3152 COG3152, Predicted membrane protein Function unknown 126208763 Pathogen - hypothetical protein APL_1297 1 None None None 126208042 Common rhlB ATP-dependent RNA helicase RhlB APL_0560 233 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 126208457 Common tktA transketolase APL_0983 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 126208858 Common - hypothetical protein APL_1394 16 COG4811 COG4811, Predicted membrane protein Function unknown 126208660 Common - hypothetical protein APL_1192 111 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 126208550 Common trxA thioredoxin APL_1078 236 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 126207932 Common hns DNA-binding protein H-NS APL_0448 32 COG2916 Hns, DNA-binding protein H-NS General function prediction only 126208076 Common rrmJ 23S rRNA methyltransferase J APL_0594 138 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 126207671 Common - predicted Mn2+ and Fe2+ transporters of the NRAMP family APL_0183 27 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 126209441 Common tatC Sec-independent protein translocase protein tatC APL_1987 205 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 126207605 Common bioB biotin synthase APL_0117 179 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 126208651 Common - hypothetical protein APL_1183 32 None None None 126208880 Common - hypothetical protein APL_1416 2 COG3134 COG3134, Predicted outer membrane lipoprotein Function unknown 126209065 Common - hypothetical protein APL_1601 197 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 126209362 Common yrhG Hypothetical transport protein yrhG APL_1902 94 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 126207531 Common pssA phosphatidylserine synthase APL_0043 30 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 126208216 Common pyrF orotidine 5'-phosphate decarboxylase APL_0736 174 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 126207954 Common trpA tryptophan synthase subunit alpha APL_0470 216 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 126209296 Common rpoH RNA polymerase factor sigma-32 APL_1834 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 126207698 Common - predicted transposase and inactivated derivatives APL_0210 20 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 126207801 Common yhiR hypothetical protein APL_0317 84 COG2961 ComJ, Protein involved in catabolism of external DNA General function prediction only 126208804 Common pepN aminopeptidase N APL_1340 161 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 126208145 Common - hypothetical protein APL_0665 57 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 126207732 Common argD acetylornithine aminotransferase (ACOAT) APL_0244 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 126208981 Common mogA molybdenum cofactor biosynthesis protein APL_1517 181 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 126207524 Pathogen - hypothetical protein APL_0036 1 None None None 126208108 Common macB putative macrolide-specific ABC-type efflux carrier APL_0626 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126209145 Common - hypothetical protein APL_1681 38 None None None 126207603 Common thyA thymidylate synthase APL_0115 135 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 126208101 Common - hypothetical protein APL_0619 86 COG2321 COG2321, Predicted metalloprotease General function prediction only 126207722 Common - putative lipoprotein APL_0234 14 COG3056 COG3056, Uncharacterized lipoprotein Cell envelope biogenesis, outer membrane 126207535 Common - hypothetical diadenosine tetraphosphatase APL_0047 8 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 126208985 Common - hypothetical protein APL_1521 40 COG2938 COG2938, Uncharacterized conserved protein Function unknown 126208107 Common - hypothetical protein APL_0625 107 COG0327 COG0327, Uncharacterized conserved protein Function unknown 126207583 Common - hypothetical protein APL_0095 13 COG3152 COG3152, Predicted membrane protein Function unknown 126208962 Common mgsA methylglyoxal synthase APL_1498 88 COG1803 MgsA, Methylglyoxal synthase Carbohydrate transport and metabolism 126208595 Common - putative cysteine desulfurase APL_1125 237 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 126209214 Common menD 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase APL_1750 82 COG1165 MenD, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Coenzyme metabolism 126208751 Common - hypothetical protein APL_1285 114 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 126208873 Common - predicted CueR-like transcriptional regulator APL_1409 18 COG0789 SoxR, Predicted transcriptional regulators Transcription 126208049 Common tsf elongation factor Ts APL_0567 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 126208689 Common - hypothetical protein APL_1221 123 COG2606 EbsC, Uncharacterized conserved protein Function unknown 126209374 Common - hypothetical protein APL_1914 4 None None None 126207875 Common macA probable macrolide-specific efflux protein APL_0391 184 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 126207773 Common ubiG 3-demethylubiquinone-9 3-methyltransferase APL_0285 177 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 126208237 Common - hypothetical protein APL_0759 84 COG1346 LrgB, Putative effector of murein hydrolase Cell envelope biogenesis, outer membrane 126207835 Common ndk nucleoside diphosphate kinase APL_0351 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 126208355 Common apfB fimbrial biogenesis protein APL_0879 216 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 126208362 Common nth endonuclease III APL_0886 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 126209266 Pathogen - hypothetical protein APL_1802 2 COG3680 COG3680, Uncharacterized protein conserved in bacteria Function unknown 126207837 Common menC O-succinylbenzoate synthase APL_0353 44 COG1441 MenC, O-succinylbenzoate synthase Coenzyme metabolism 126208868 Common oapB opacity associated protein B APL_1404 3 None None None 126208482 Common hemX putative uroporphyrin-III C-methyltransferase APL_1008 49 COG2959 HemX, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 126208819 Common - hypothetical protein APL_1355 110 COG1881 COG1881, Phospholipid-binding protein General function prediction only 126209256 Common - Fe(III) dicitrate ABC transporter, permease APL_1792 191 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 126207653 Common rnfA Na(+)-translocating NADH-quinone reductase subunit E APL_0165 76 COG4657 RnfA, Predicted NADH:ubiquinone oxidoreductase, subunit RnfA Energy production and conversion 126208586 Common - hypothetical protein APL_1114 48 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 126209387 Common surE 5'-nucleotidase surE APL_1927 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 126209185 Common rplL 50S ribosomal protein L7/L12 APL_1721 214 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 126209103 Common slyX hypothetical protein APL_1639 33 COG2900 SlyX, Uncharacterized protein conserved in bacteria Function unknown 126208377 Common - ribosome-associated inhibitor A APL_0901 49 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 126209095 Common glmS D-fructose-6-phosphate amidotransferase APL_1631 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 126208547 Common purA adenylosuccinate synthetase APL_1075 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 126209351 Common - hypothetical protein APL_1891 17 COG3120 COG3120, Uncharacterized protein conserved in bacteria Function unknown 126209315 Common ilvC ketol-acid reductoisomerase APL_1853 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 126208814 Common tehB tellurite resistance protein TehB APL_1350 40 COG3615 TehB, Uncharacterized protein/domain, possibly involved in tellurite resistance Inorganic ion transport and metabolism 126208445 Common - putative acyl CoA thioester hydrolase APL_0971 137 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 126209474 Common hisD histidinol dehydrogenase APL_2020 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 126208924 Common - hypothetical protein APL_1460 49 COG4804 COG4804, Uncharacterized conserved protein Function unknown 126208935 Common - putative sugar transferase APL_1471 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 126208220 Common rpsA 30S ribosomal protein S1 APL_0740 225 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 126209028 Common lyx putative L-xylulose kinase APL_1564 178 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 126208658 Common - putative transcriptional regulator LysR-like protein APL_1190 163 COG0583 LysR, Transcriptional regulator Transcription 126208485 Common adh2 aldehyde-alcohol dehydrogenase 2 APL_1011 176 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 126208065 Common - hypothetical protein APL_0583 31 COG3083 COG3083, Predicted hydrolase of alkaline phosphatase superfamily General function prediction only 126208899 Pathogen - hypothetical protein APL_1435 1 None None None 126207894 Common - hypothetical outer membrane protein APL_0410 12 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 126208668 Common - putative DNA mismatch endonuclease APL_1200 71 COG3727 Vsr, DNA G:T-mismatch repair endonuclease DNA replication, recombination, and repair 126207843 Common nlpC putative lipoprotein APL_0359 131 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 126209073 Common - hypothetical protein APL_1609 5 COG2979 COG2979, Uncharacterized protein conserved in bacteria Function unknown 126208020 Common - putative ABC transporter substrate-binding protein APL_0538 101 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 126207658 Common rnfG electron transport complex protein RnfG APL_0170 59 COG4659 RnfG, Predicted NADH:ubiquinone oxidoreductase, subunit RnfG Energy production and conversion 126209434 Common - hypothetical protein APL_1980 5 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 126209111 Common atpG F0F1 ATP synthase subunit gamma APL_1647 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 126207513 Common recN DNA repair protein RecN APL_0025 216 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 126207633 Common - hypothetical protein APL_0145 49 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 126208645 Common - hypothetical protein APL_1177 51 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 126208867 Common rfaF ADP-heptose:LPS heptosyltransferase II APL_1403 107 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 126208548 Common hflC protein HflC APL_1076 207 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 126207688 Common hofQ type II secretory pathway, component HofQ APL_0200 141 COG4796 HofQ, Type II secretory pathway, component HofQ Intracellular trafficking and secretion 126209126 Common - PTS system mannose-specific EIIAB component APL_1662 76 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 126208119 Common - hypothetical protein APL_0637 180 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 126208227 Common - potassium efflux protein KefA APL_0749 183 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 126208797 Common hybB predicted hydrogenase 2 cytochrome b type component APL_1333 30 COG5557 COG5557, Polysulphide reductase Energy production and conversion 126207973 Pathogen - hypothetical protein APL_0489 1 None None None 126207917 Common msrB methionine sulfoxide reductase B APL_0433 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 126208470 Common galM aldose 1-epimerase APL_0996 91 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 126208154 Common - hypothetical protein APL_0674 114 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 126208954 Common trmE tRNA modification GTPase TrmE APL_1490 234 COG0486 ThdF, Predicted GTPase General function prediction only 126207813 Common - 2-octaprenyl-6-methoxyphenol hydroxylase APL_0329 120 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 126209458 Common comF Competence protein F APL_2004 162 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 126208465 Common - hypothetical protein APL_0991 89 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 126209498 Common prfA peptide chain release factor 1 APL_2044 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 126207787 Common tolB translocation protein TolB precursor APL_0303 155 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 126208247 Common ushA bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor APL_0769 141 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 126209305 Common cysJ Sulfite reductase [NADPH] flavoprotein alpha-component (SIR-FP) APL_1843 107 COG0369 CysJ, Sulfite reductase, alpha subunit (flavoprotein) Inorganic ion transport and metabolism 126207490 Common dnaN DNA polymerase III subunit beta APL_0002 215 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 126208434 Common purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase APL_0958 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 126207850 Common - hypothetical protein APL_0366 17 COG2707 COG2707, Predicted membrane protein Function unknown 126208456 Common rpmE 50S ribosomal protein L31 APL_0982 204 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 126209260 Common - hypothetical protein APL_1796 18 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 126208497 Common - hypothetical protein APL_1023 49 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 126207611 Common - glyoxalase II family protein APL_0123 201 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 126209179 Common sgaB Phosphotransferase system, galactitol-specific IIB component APL_1715 32 COG3414 SgaB, Phosphotransferase system, galactitol-specific IIB component Carbohydrate transport and metabolism 126209175 Common def peptide deformylase APL_1711 215 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 126209259 Common - putative periplasmic iron/siderophore binding protein APL_1795 97 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 126207572 Common trxB thioredoxin reductase APL_0084 247 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 126208382 Common - putative acetyltransferase APL_0906 209 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 126208896 Common - putative NAD(P)H oxidoreductase APL_1432 93 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 126207657 Common rnfD electron transport complex protein RnfD APL_0169 78 COG4658 RnfD, Predicted NADH:ubiquinone oxidoreductase, subunit RnfD Energy production and conversion 126208998 Common - putative transport system permease protein APL_1534 22 None None None 126209131 Common gntR HTH-type transcriptional regulator APL_1667 128 COG1609 PurR, Transcriptional regulators Transcription 126208459 Common - transposase APL_0985 36 None None None 126209016 Common wecB UDP-N-acetylglucosamine 2-epimerase APL_1552 157 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 126207961 Common - hypothetical protein APL_0477 58 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 126208697 Common - nucleotide-binding protein APL_1231 107 COG1666 COG1666, Uncharacterized protein conserved in bacteria Function unknown 126208205 Common cspD cold shock-like protein CspD APL_0725 171 COG1278 CspC, Cold shock proteins Transcription 126208433 Common - hypothetical protein APL_0957 87 COG1444 COG1444, Predicted P-loop ATPase fused to an acetyltransferase General function prediction only 126208167 Common dld D-lactate dehydrogenase APL_0687 68 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 126208754 Common - hypothetical protein APL_1288 12 COG3113 COG3113, Predicted NTP binding protein (contains STAS domain) General function prediction only 126207629 Common - hypothetical protein APL_0141 53 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 126208087 Common - hypothetical protein APL_0605 13 COG5595 COG5595, Zn-ribbon-containing, possibly nucleic-acid-binding protein General function prediction only 126208271 Common sapB peptide transport system permease protein SapB APL_0795 215 COG4168 SapB, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 126207627 Common leuC isopropylmalate isomerase large subunit APL_0139 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 126208189 Common - hypothetical protein APL_0709 22 COG2926 COG2926, Uncharacterized protein conserved in bacteria Function unknown 126208770 Common cysZ putative sulfate transport protein CysZ APL_1304 40 COG2981 CysZ, Uncharacterized protein involved in cysteine biosynthesis Amino acid transport and metabolism 126208831 Common ccmF cytochrome c-type biogenesis protein CcmF APL_1367 146 COG1138 CcmF, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 126208240 Common - hypothetical protein APL_0762 153 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 126209375 Common panF sodium/panthothenate symporter APL_1915 178 COG4145 PanF, Na+/panthothenate symporter Coenzyme metabolism 126207563 Common ybaB uncharacterized protein YbaB APL_0075 172 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 126207865 Common glpC sn-glycerol-3-phosphate dehydrogenase subunit C APL_0381 180 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 126208422 Common - hypothetical protein APL_0946 7 COG2388 COG2388, Predicted acetyltransferase General function prediction only 126208401 Common hscA chaperone protein HscA APL_0925 234 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 126207929 Common ykgF putative electron transport protein APL_0445 95 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 126208862 Common tufB elongation factor Tu APL_1398 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 126208125 Common - hypothetical protein APL_0643 9 COG3422 COG3422, Uncharacterized conserved protein Function unknown 126207832 Common glgC glucose-1-phosphate adenylyltransferase APL_0348 163 COG0448 GlgC, ADP-glucose pyrophosphorylase Carbohydrate transport and metabolism 126208711 Common - hypothetical protein APL_1245 55 COG2862 COG2862, Predicted membrane protein Function unknown 126207509 Common ftsQ cell division protein FtsQ APL_0021 72 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 126209423 Common dfp bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase APL_1969 235 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 126209064 Common - hypothetical protein APL_1600 162 COG1576 COG1576, Uncharacterized conserved protein Function unknown 126208879 Pathogen - hypothetical protein APL_1415 1 None None None 126209442 Common hemB delta-aminolevulinic acid dehydratase APL_1988 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 126208058 Common nlpI lipoprotein NlpI APL_0576 65 COG4785 NlpI, Lipoprotein NlpI, contains TPR repeats General function prediction only 126208915 Common - hypothetical protein APL_1451 5 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 126208991 Common frdC fumarate reductase subunit C APL_1527 23 COG3029 FrdC, Fumarate reductase subunit C Energy production and conversion 126208199 Common - putative phosphate permease APL_0719 171 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 126209332 Common - hypothetical protein APL_1870 12 COG3087 FtsN, Cell division protein Cell division and chromosome partitioning 126207910 Common - hypothetical protein APL_0426 2 None None None 126208092 Common ihfA integration host factor, alpha chain APL_0610 198 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 126208835 Common ccmB heme exporter protein B APL_1371 80 COG2386 CcmB, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 126209369 Common xylF D-xylose transporter subunit XylF APL_1909 106 COG4213 XylF, ABC-type xylose transport system, periplasmic component Carbohydrate transport and metabolism 126207619 Common gcvA glycine cleavage system transcriptional activator-like protein APL_0131 185 COG0583 LysR, Transcriptional regulator Transcription 126208192 Common - hypothetical protein APL_0712 34 COG3100 COG3100, Uncharacterized protein conserved in bacteria Function unknown 126208039 Common tadV flp operon protein B APL_0557 28 COG4960 CpaA, Flp pilus assembly protein, protease CpaA Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 126209085 Common cbiQ putative ABC transport permease protein CbiQ APL_1621 17 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 126208281 Common - hypothetical protein APL_0805 52 COG3217 COG3217, Uncharacterized Fe-S protein General function prediction only 126209406 Common - hypothetical protein APL_1948 14 None None None 126208653 Common - hypothetical protein APL_1185 3 None None None 126208583 Common nagZ beta-hexosaminidase APL_1111 178 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 126208762 Common mdh malate dehydrogenase APL_1296 188 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 126209450 Common rssA hypothetical protein APL_1996 42 COG4667 COG4667, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 126208467 Common nrdB ribonucleotide-diphosphate reductase subunit beta APL_0993 150 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 126207926 Common sanA SanA protein APL_0442 43 COG2949 SanA, Uncharacterized membrane protein Function unknown 126208524 Common nrfE cytochrome c-type biogenesis protein NrfE APL_1052 141 COG1138 CcmF, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 126207703 Common - hypothetical protein APL_0215 19 None None None 126209391 Common tagI 3-methyladenine-DNA glycosidase APL_1931 133 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 126207949 Common - hypothetical protein APL_0465 89 COG0393 COG0393, Uncharacterized conserved protein Function unknown 126207998 Pathogen - hypothetical protein APL_0514 4 None None None 126207826 Common - hypothetical protein APL_0342 132 COG1704 LemA, Uncharacterized conserved protein Function unknown 126209418 Common - hypothetical protein APL_1964 7 COG1694 MazG, Predicted pyrophosphatase General function prediction only 126208608 Common - hypothetical protein APL_1138 52 COG2960 COG2960, Uncharacterized protein conserved in bacteria Function unknown 126209300 Common asnC DNA-binding transcriptional regulator AsnC APL_1838 159 COG1522 Lrp, Transcriptional regulators Transcription 126208173 Common moaE molybdopterin-converting factor subunit 2 APL_0693 159 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 126208663 Common - hypothetical protein APL_1195 48 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 126207993 Common - bacteriophage capsid protein APL_0509 37 COG5511 COG5511, Bacteriophage capsid protein General function prediction only 126207940 Common znuC high-affinity zinc uptake system ATP-binding protein ZnuC APL_0456 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 126208607 Common pgi glucose-6-phosphate isomerase APL_1137 197 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 126208677 Common betT putative choline-glycine betaine transporter APL_1209 96 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 126207579 Common pepQ Xaa-Pro dipeptidase APL_0091 106 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 126208514 Common dinP DNA polymerase IV APL_1040 185 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 126209469 Common fhuB iron-hydroxamate transporter permease subunit APL_2015 189 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 126207534 Common nadR nicotinamide-nucleotide adenylyltransferase APL_0046 28 COG3172 NadR, Predicted ATPase/kinase involved in NAD metabolism Coenzyme metabolism 126209104 Common fkpA putative FKBP-type peptidyl-prolyl cis-trans isomerase APL_1640 147 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 126208961 Common - putative integral membrane protein APL_1497 50 COG1289 COG1289, Predicted membrane protein Function unknown 126209188 Pathogen - hypothetical protein APL_1724 1 None None None 126208203 Common tgt queuine tRNA-ribosyltransferase APL_0723 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 126208578 Common purT phosphoribosylglycinamide formyltransferase 2 APL_1106 219 COG0027 PurT, Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) Nucleotide transport and metabolism 126207637 Common - predicted gluconate transport-associated protein APL_0149 69 COG0316 IscA, Uncharacterized conserved protein Function unknown 126208859 Common manA mannose-6-phosphate isomerase APL_1395 43 COG1482 ManA, Phosphomannose isomerase Carbohydrate transport and metabolism 126209217 Common nanK N-acetylmannosamine kinase APL_1753 159 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 126208373 Common folD bifunctional protein FolD APL_0897 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 126207802 Common pyrE orotate phosphoribosyltransferase APL_0318 133 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 126208290 Common - hypothetical protein APL_0814 58 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 126207666 Common - hypothetical protein APL_0178 8 None None None 126207538 Common - hypothetical protein APL_0050 6 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 126208354 Common apfC fimbrial biogenesis protein APL_0878 145 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 126208061 Common mukF condesin subunit F APL_0579 19 COG3006 MukF, Uncharacterized protein involved in chromosome partitioning Cell division and chromosome partitioning 126209363 Common - hypothetical protein APL_1903 32 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 126209240 Common rpsE 30S ribosomal protein S5 APL_1776 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 126208773 Common - putative permease APL_1309 76 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 126207733 Pathogen - transferrin binding protein-like solute binding protein APL_0245 3 None None None 126208641 Common pnuC nicotinamide mononucleotide transporter APL_1173 34 COG3201 PnuC, Nicotinamide mononucleotide transporter Coenzyme metabolism 126207804 Common metC cystathionine beta-lyase APL_0320 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 126207649 Common rdgC recombination associated protein APL_0161 53 COG2974 RdgC, DNA recombination-dependent growth factor C DNA replication, recombination, and repair 126207576 Common rluE ribosomal large subunit pseudouridine synthase E APL_0088 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 126207544 Common yicC hypothetical protein APL_0056 137 COG1561 COG1561, Uncharacterized stress-induced protein Function unknown 126209165 Common ulaG putative L-ascorbate 6-phosphate lactonase APL_1701 20 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 126208612 Common recX regulatory protein RecX APL_1142 42 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 126208855 Common - PTS system mannose-specific EIIAB component APL_1391 79 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 126209342 Common - hypothetical protein APL_1882 16 COG4947 COG4947, Uncharacterized protein conserved in bacteria Function unknown 126208849 Common plsX fatty acid/phospholipid synthesis protein APL_1385 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 126209481 Common hisF Imidazole glycerol phosphate synthase subunit hisF APL_2027 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 126208398 Common - hypothetical protein APL_0922 5 None None None 126208299 Common glpR glycerol-3-phosphate regulon repressor APL_0823 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 126207765 Common uvrC excinuclease ABC subunit C APL_0277 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 126209327 Common accC acetyl-CoA carboxylase biotin carboxylase subunit APL_1865 235 COG0439 AccC, Biotin carboxylase Lipid metabolism 126208071 Common - hypothetical protein APL_0589 14 COG4357 COG4357, Uncharacterized conserved protein Function unknown 126208502 Common - putative glycosyltransferase APL_1028 15 COG3306 COG3306, Glycosyltransferase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 126209350 Common lonH putative protease La-like protein APL_1890 99 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 126208008 Common - predicted phage tail protein APL_0524 24 COG4733 COG4733, Phage-related protein, tail component Function unknown 126208102 Common aroG phospho-2-dehydro-3-heoxyheptonate aldolase APL_0620 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 126208555 Common arcD putative arginine/ornithine antiporter APL_1083 116 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 126209371 Common xylH Xylose transport system permease protein xylH APL_1911 129 COG4214 XylH, ABC-type xylose transport system, permease component Carbohydrate transport and metabolism 126208491 Common - hypothetical protein APL_1017 35 COG2364 COG2364, Predicted membrane protein Function unknown 126207590 Common nrfC nitrate reductase APL_0102 166 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 126208080 Common glnD PII uridylyl-transferase APL_0598 123 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 126208593 Common - hypothetical protein APL_1123 8 None None None 126209060 Common dacA D-alanyl-D-alanine carboxypeptidase fraction A APL_1596 155 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 126207608 Common prc carboxy-terminal protease APL_0120 182 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 126208423 Common - transposase APL_0947 21 COG3677 COG3677, Transposase and inactivated derivatives DNA replication, recombination, and repair 126208845 Common - hypothetical protein APL_1381 47 COG0762 COG0762, Predicted integral membrane protein Function unknown 126208536 Common qseC sensor protein QseC APL_1064 215 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126207759 Common - putative chelated iron transport system ATP-binding protein APL_0271 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 126207778 Common uupA ABC transporter ATPase component APL_0294 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 126208840 Common oadA pyruvate carboxylase subunit B APL_1376 199 COG5016 COG5016, Pyruvate/oxaloacetate carboxyltransferase Energy production and conversion 126208364 Common fadJ putative fatty acid oxidation complex alpha subunit APL_0888 164 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 126209291 Common - hypothetical protein APL_1829 2 None None None 126209340 Common mscS Small-conductance mechanosensitive channel APL_1880 197 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 126208219 Common ihfB integration host factor beta-subunit APL_0739 202 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 126209203 Common mutY A/G-specific adenine glycosylase APL_1739 234 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 126208342 Common - hypothetical protein APL_0866 42 COG3106 COG3106, Predicted ATPase General function prediction only 126208803 Common mfd transcription-repair coupling factor APL_1339 224 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 126208162 Common hpt yypoxanthine phosphoribosyltransferase APL_0682 151 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 126209144 Common - hypothetical protein APL_1680 12 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 126207723 Common bolA stress-induced morphogen (activity unknown) APL_0235 97 COG0271 BolA, Stress-induced morphogen (activity unknown) Signal transduction mechanisms 126207549 Common yibK putative tRNA/rRNA methyltransferase APL_0061 161 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 126209320 Common - hypothetical protein APL_1858 4 COG1979 COG1979, Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family Energy production and conversion 126208828 Common gmhA putative phosphoheptose isomerase APL_1364 117 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 126208966 Common valS valyl-tRNA synthetase APL_1502 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126209279 Common tdk thymidylate kinase APL_1817 232 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 126208286 Common cafA ribonuclease G APL_0810 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 126208228 Common - potassium efflux protein KefA APL_0750 211 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 126209048 Common cpxB capsule polysaccharide export inner-membrane protein APL_1584 77 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 126208109 Common - two-component sensor protein APL_0627 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 126209094 Common mtlA PTS system mannitol-specific EIICBA component APL_1630 73 COG2213 MtlA, Phosphotransferase system, mannitol-specific IIBC component Carbohydrate transport and metabolism 126209099 Common - putative adhesin processing HmwC-like protein APL_1635 19 COG3914 Spy, Predicted O-linked N-acetylglucosamine transferase, SPINDLY family Posttranslational modification, protein turnover, chaperones 126207681 Common aroB 3-dehydroquinate synthase APL_0193 213 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 126208629 Common - hypothetical protein APL_1161 205 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 126208823 Common dipZ thiol:disulfide interchange protein precursor APL_1359 153 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 126209083 Common utp urea transport protein ApUT APL_1619 19 COG4413 Utp, Urea transporter Amino acid transport and metabolism 126208743 Common - hypothetical protein APL_1277 52 COG2835 COG2835, Uncharacterized conserved protein Function unknown 126208476 Common - hypothetical protein APL_1002 158 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 126207699 Common glyA serine hydroxymethyltransferase APL_0211 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 126208795 Common hyaA hydrogenase 2 small subunit APL_1331 77 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 126207798 Common hepA ATP-dependent helicase HepA APL_0314 121 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 126208623 Common ruvC Holliday junction resolvase APL_1153 195 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 126208750 Common - putative DNA-binding protein APL_1284 35 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 126208392 Common - transposase APL_0916 8 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 126209230 Common rpsC 30S ribosomal protein S3 APL_1766 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 126207495 Common lpxB lipid-A-disaccharide synthase APL_0007 139 COG0763 LpxB, Lipid A disaccharide synthetase Cell envelope biogenesis, outer membrane 126208850 Common rpmF 50S ribosomal protein L32 APL_1386 67 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 126208095 Common - hypothetical transposase APL_0613 19 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 126207859 Common glpK glycerol kinase APL_0375 178 COG0554 GlpK, Glycerol kinase Energy production and conversion 126208277 Common ftsB cell division protein FtsB-like protein APL_0801 60 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 126209033 Common exbD biopolymer transport ExbD protein APL_1569 139 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 126207663 Common dksA DnaK suppressor protein APL_0175 151 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 126209269 Common xerC site-specific tyrosine recombinase XerC APL_1805 230 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 126209446 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase APL_1992 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 126208570 Common - putative 6-pyruvoyl tetrahydrobiopterin synthase APL_1098 120 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 126208458 Common - putative transposase APL_0984 20 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 126209492 Common lolC Lipoprotein-releasing system transmembrane protein lolC APL_2038 147 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 126208444 Common - hypothetical protein APL_0970 59 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 126207889 Common relA GTP pyrophosphokinase APL_0405 205 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 126208739 Common - putative fimbrial biogenesis and twitching motility protein PilF-like protein APL_1273 58 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 126207690 Common thiL Thiamine-monophosphate kinase APL_0202 189 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 126208332 Common sdaC serine transporter APL_0856 36 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 126208733 Common - hypothetical protein APL_1267 89 COG0778 NfnB, Nitroreductase Energy production and conversion 126208982 Common glnB nitrogen regulatory protein P-II APL_1518 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 126208260 Common uvrA UvrABC system protein A APL_0782 242 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 126207639 Common nqrB Na(+)-translocating NADH-quinone reductase subunit B APL_0151 76 COG1805 NqrB, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB Energy production and conversion 126208262 Common - hypothetical protein APL_0784 7 None None None 126207597 Common - hypothetical protein APL_0109 196 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 126208650 Common - hypothetical protein APL_1182 48 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 126209275 Common - hypothetical protein APL_1811 7 None None None 126208305 Common - hypothetical protein APL_0829 122 COG0729 COG0729, Outer membrane protein Cell envelope biogenesis, outer membrane 126207489 Common dnaA chromosomal replication initiator protein APL_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 126209242 Common rplO 50S ribosomal protein L15 APL_1778 94 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 126207914 Common - hypothetical protein APL_0430 185 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 126208714 Common - AzlC family protein APL_1248 99 COG1296 AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) Amino acid transport and metabolism 126208684 Common luxS S-ribosylhomocysteinase APL_1216 55 COG1854 LuxS, LuxS protein involved in autoinducer AI2 synthesis Signal transduction mechanisms 126209043 Common cps5C region 2 capsular polysaccharide biosynthesis protein APL_1579 16 COG4421 COG4421, Capsular polysaccharide biosynthesis protein Carbohydrate transport and metabolism 126208118 Common hsdR3 putative type I site-specific restriction-modification system, restriction subunit APL_0636 134 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 126207710 Common - putative lipoprotein APL_0222 22 COG4380 COG4380, Uncharacterized protein conserved in bacteria Function unknown 126208693 Common - hypothetical protein APL_1227 6 None None None 126207529 Common - hypothetical protein APL_0041 6 None None None 126208760 Common - hypothetical protein APL_1294 112 COG1090 COG1090, Predicted nucleoside-diphosphate sugar epimerase General function prediction only 126207951 Common - hypothetical protein APL_0467 75 COG2983 COG2983, Uncharacterized conserved protein Function unknown 126208914 Common fbp fructose-1,6-bisphosphatase APL_1450 108 COG0158 Fbp, Fructose-1,6-bisphosphatase Carbohydrate transport and metabolism 126207692 Common - putative threonine efflux protein APL_0204 58 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 126209249 Common rplQ 50S ribosomal protein L17 APL_1785 215 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 126208316 Common - predicted outer membrane protein APL_0840 109 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 126209109 Common atpC F0F1 ATP synthase subunit epsilon APL_1645 182 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 126209318 Common - hypothetical protein APL_1856 17 None None None 126208519 Common - hypothetical protein APL_1045 85 COG2962 RarD, Predicted permeases General function prediction only 126208054 Common pdxS pyridoxine biosynthesis protein APL_0572 87 COG0214 SNZ1, Pyridoxine biosynthesis enzyme Coenzyme metabolism 126208818 Common artP arginine transporter ATP-binding subunit APL_1354 249 COG4161 ArtP, ABC-type arginine transport system, ATPase component Amino acid transport and metabolism 126209051 Common fmt methionyl-tRNA formyltransferase APL_1587 217 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 126209415 Common hfq RNA-binding protein Hfq APL_1961 127 COG1923 Hfq, Uncharacterized host factor I protein General function prediction only 126207568 Common - putative thioredoxin-like protein APL_0080 126 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 126208600 Common - putative protease APL_1130 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 126208155 Common asnC asparaginyl-tRNA synthetase APL_0675 230 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 126209208 Common ubiF 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase APL_1744 131 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 126209013 Common wecE TDP-4-oxo-6-deoxy-D-glucose transaminase APL_1549 195 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 126208137 Common sspB ClpXP protease specificity-enhancing factor APL_0657 64 COG2969 SspB, Stringent starvation protein B General function prediction only 126207707 Common thrS threonyl-tRNA synthetase APL_0219 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126207823 Common pepC phosphoenolpyruvate carboxylase APL_0339 116 COG2352 Ppc, Phosphoenolpyruvate carboxylase Energy production and conversion 126209455 Common - hypothetical protein APL_2001 107 COG2962 RarD, Predicted permeases General function prediction only 126207992 Common - predicted bacteriophage tail assembly protein APL_0508 35 COG5525 COG5525, Bacteriophage tail assembly protein General function prediction only 126208451 Common xthA exonuclease III APL_0977 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 126209288 Common rpoZ DNA-directed RNA polymerase subunit omega APL_1826 41 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 126208589 Common cyaY frataxin-like protein APL_1117 42 COG1965 CyaY, Protein implicated in iron transport, frataxin homolog Inorganic ion transport and metabolism 126208713 Common - hypothetical protein APL_1247 13 COG4541 COG4541, Predicted membrane protein Function unknown 126207512 Common lpxC UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase APL_0024 139 COG0774 LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase Cell envelope biogenesis, outer membrane 126207718 Common gpmB phosphoglycerate mutase/fructose-2, 6-bisphosphatase APL_0230 178 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 126209329 Common - hypothetical protein APL_1867 18 COG3084 COG3084, Uncharacterized protein conserved in bacteria Function unknown 126209257 Common - Fe(III) dicitrate ABC transporter, ATP-binding protein APL_1793 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 126207825 Common - hypothetical protein APL_0341 48 COG3762 COG3762, Predicted membrane protein Function unknown 126207700 Common pnnK probable inorganic polyphosphate/ATP-NAD kinase APL_0212 241 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 126207948 Common - putative deoxyribonucleotide triphosphate pyrophosphatase APL_0464 237 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 126208181 Common - O-acetylhomoserine (thiol)-lyase APL_0701 206 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 126208893 Common napA periplasmic nitrate reductase precursor APL_1429 183 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 126208529 Pathogen - transposase APL_1057 1 None None None 126208270 Common sapC peptide transport system permease protein SapC APL_0794 182 COG4171 SapC, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 126207626 Common leuD isopropylmalate isomerase small subunit APL_0138 209 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 126208298 Common ubiA 4-hydroxybenzoate octaprenyltransferase APL_0822 192 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 126207986 Common - hypothetical protein APL_0502 6 None None None 126209333 Common - hypothetical protein APL_1871 51 None None None 126209445 Common brnQ Branched-chain amino acid transport system carrier protein braB (Branched-chain amino acid uptake carrier braB) APL_1991 50 COG1114 BrnQ, Branched-chain amino acid permeases Amino acid transport and metabolism 126208513 Common htpX heat shock protein HtpX APL_1039 176 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 126208169 Common torY cytochrome c-type protein TorY APL_0689 54 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 126207864 Common glpB anaerobic glycerol-3-phosphate dehydrogenase subunit B APL_0380 32 COG3075 GlpB, Anaerobic glycerol-3-phosphate dehydrogenase Amino acid transport and metabolism 126207946 Common narQ nitrate/nitrite sensor protein NarQ APL_0462 133 COG3850 NarQ, Signal transduction histidine kinase, nitrate/nitrite-specific Signal transduction mechanisms 126209424 Common radC DNA repair protein RadC APL_1970 179 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 126208067 Common - hypothetical protein APL_0585 64 COG1309 AcrR, Transcriptional regulator Transcription 126208415 Common bioC biotin synthesis protein APL_0939 84 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 126208148 Common - hypothetical protein APL_0668 27 COG2822 COG2822, Predicted periplasmic lipoprotein involved in iron transport Inorganic ion transport and metabolism 126207508 Common ddl D-alanine--D-alanine ligase APL_0020 217 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 126208111 Common cpxR transcriptional regulatory protein CpxR APL_0629 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126209191 Common rpoB DNA-directed RNA polymerase subunit beta APL_1727 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 126208341 Common aape0934 hypothetical protein APL_0865 56 COG3025 COG3025, Uncharacterized conserved protein Function unknown 126208508 Common prlC oligopeptidase A APL_1034 125 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 126208549 Common hflK protein HflK APL_1077 216 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 126208631 Common trpE anthranilate synthase component 1 APL_1163 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 126208348 Common leuS leucyl-tRNA synthetase APL_0872 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126208383 Common - hypothetical protein APL_0907 65 COG1073 COG1073, Hydrolases of the alpha/beta superfamily General function prediction only 126207856 Common corC magnesium and cobalt efflux protein APL_0372 218 COG4535 CorC, Putative Mg2+ and Co2+ transporter CorC Inorganic ion transport and metabolism 126208478 Common nhaP Na(+)/H(+) exchanger beta-like protein APL_1004 104 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 126208942 Common vacB ribonuclease R APL_1478 198 COG0557 VacB, Exoribonuclease R Transcription 126208992 Common frdB fumarate reductase iron-sulfur subunit APL_1528 208 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 126207618 Common engC ribosome-associated GTPase APL_0130 164 COG1162 COG1162, Predicted GTPases General function prediction only 126208652 Common - hypothetical protein APL_1184 14 None None None 126207938 Common sucB dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E2) APL_0454 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 126208838 Common - hypothetical protein APL_1374 14 None None None 126208883 Common mglA galactose/methyl galaxtoside transporter ATP-binding protein APL_1419 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 126209378 Common vacJ lipoprotein VacJ-like protein precursor APL_1918 94 COG2853 VacJ, Surface lipoprotein Cell envelope biogenesis, outer membrane 126207788 Common palA outer membrane protein precursor PalA APL_0304 143 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 126208834 Common ccmC heme exporter protein C APL_1370 126 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 126208002 Common - hypothetical protein APL_0518 29 COG5281 COG5281, Phage-related minor tail protein Function unknown 126207814 Pathogen - hypothetical protein APL_0330 2 None None None 126207749 Common modB molybdate ABC transporter permease protein APL_0261 213 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 126208418 Common bioA adenosylmethionine--8-amino-7-oxononanoate transaminase APL_0942 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 126209491 Common lolD Lipoprotein-releasing system ATP-binding protein lolD APL_2037 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 126208979 Common - hypothetical protein APL_1515 86 COG3088 CcmH, Uncharacterized protein involved in biosynthesis of c-type cytochromes Posttranslational modification, protein turnover, chaperones 126208949 Common pdxY pyridoxamine kinase APL_1485 76 COG2240 PdxK, Pyridoxal/pyridoxine/pyridoxamine kinase Coenzyme metabolism 126208609 Common aroE shikimate 5-dehydrogenase APL_1139 222 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 126208437 Common hemN coproporphyrinogen III oxidase APL_0963 203 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 126208634 Common - putative ubiquinone/menaquinone biosynthesis methyltransferase APL_1166 76 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 126209407 Common dtd D-tyrosyl-tRNA deacylase APL_1949 139 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 126207493 Common asd aspartate-semialdehyde dehydrogenase APL_0005 200 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 126207740 Common alr alanine racemase APL_0252 200 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 126207849 Common hrpA ATP-dependent RNA helicase HrpA APL_0365 135 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 126208460 Common - hypothetical transposase-like protein APL_0986 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 126208664 Common - type I restriction enzyme, R subunit APL_1196 125 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 126208009 Common - hypothetical protein APL_0525 2 None None None 126208098 Common rnd ribonuclease D APL_0616 122 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 126207764 Common frpB iron-regulated outer membrane protein B APL_0276 70 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 126207682 Common aroK shikimate kinase APL_0194 199 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 126208535 Common qseB transcriptional regulatory protein QseB APL_1063 216 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 126207586 Common ilvM acetolactate synthase 2 regulatory subunit APL_0098 24 COG3978 COG3978, Acetolactate synthase (isozyme II), small (regulatory) subunit Function unknown 126207895 Common D15 protective surface antigen D15 precursor APL_0411 161 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 126209138 Common dmsA anaerobic dimethyl sulfoxide reductase chain A precursor APL_1674 184 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 126208999 Common anmK anhydro-N-acetylmuramic acid kinase APL_1535 120 COG2377 COG2377, Predicted molecular chaperone distantly related to HSP70-fold metalloproteases Posttranslational modification, protein turnover, chaperones 126209026 Common selA selenocysteine synthase APL_1562 72 COG1921 SelA, Selenocysteine synthase [seryl-tRNASer selenium transferase] Amino acid transport and metabolism 126208188 Common ppx exopolyphosphatase APL_0708 180 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 126208749 Common - putative ABC transporter ATP-binding protein APL_1283 246 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 126207779 Common - hypothetical protein APL_0295 222 COG1179 COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Coenzyme metabolism 126208543 Common - hypothetical protein APL_1071 136 COG2252 COG2252, Permeases General function prediction only 126207962 Common - hypothetical protein APL_0478 57 COG1275 TehA, Tellurite resistance protein and related permeases Inorganic ion transport and metabolism 126209118 Common gidB glucose-inhibited division protein B APL_1654 202 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 126209216 Common nanE N-acetylmannosamine-6-phosphate 2-epimerase APL_1752 43 COG3010 NanE, Putative N-acetylmannosamine-6-phosphate epimerase Carbohydrate transport and metabolism 126209314 Common ompA Outer membrane protein P5 precursor (OMP P5) APL_1852 135 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 126209290 Common - PilT protein-like protein APL_1828 36 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 126207573 Common kdsB 3-deoxy-manno-octulosonate cytidylyltransferase APL_0085 142 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 126209393 Common - hypothetical protein APL_1935 11 COG3314 COG3314, Uncharacterized protein conserved in bacteria Function unknown 126209466 Common - hypothetical protein APL_2012 50 COG1584 COG1584, Predicted membrane protein Function unknown 126208561 Common arsC arsenate reductase APL_1089 111 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 126209036 Common - hypothetical protein APL_1572 44 COG2431 COG2431, Predicted membrane protein Function unknown 126207644 Common apbE thiamine biosynthesis lipoprotein ApbE precursor APL_0156 139 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 126209003 Common - hypothetical protein APL_1539 25 COG4453 COG4453, Uncharacterized protein conserved in bacteria Function unknown 126208554 Common arcD putative arginine/ornithine antiporter APL_1082 147 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 126208085 Common - hypothetical protein APL_0603 4 None None None 126208648 Common - hypothetical oxidoreductase APL_1180 185 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 126208202 Common - hypothetical protein APL_0722 17 None None None 126208090 Common pheS phenylalanyl-tRNA synthetase subunit alpha APL_0608 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 126209389 Common - lipoprotein APL_1929 7 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 126208327 Common - ABC transporter, ATP-binding subunit APL_0851 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 126207533 Common ribF riboflavin biosynthesis protein APL_0045 211 COG0196 RibF, FAD synthase Coenzyme metabolism 126208716 Common fba fructose-bisphosphate aldolase APL_1250 149 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 126208761 Common argR arginine repressor APL_1295 79 COG1438 ArgR, Arginine repressor Transcription 126209488 Common scrK aminoimidazole riboside kinase APL_2034 160 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 126207781 Common cydA cytochrome oxidase subunit 1 APL_0297 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 126209027 Common mioC flavodoxin APL_1563 72 COG0716 FldA, Flavodoxins Energy production and conversion 126209072 Common - hypothetical protein APL_1608 15 COG3691 COG3691, Uncharacterized protein conserved in bacteria Function unknown 126209456 Common - hypothetical protein APL_2002 14 None None None 126209425 Common rpmB 50S ribosomal protein L28 APL_1971 153 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 126207610 Common - hypothetical protein APL_0122 64 COG3108 COG3108, Uncharacterized protein conserved in bacteria Function unknown 126208471 Common lacZ beta-galactosidase APL_0997 67 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 126208251 Common aceE pyruvate dehydrogenase subunit E1 APL_0773 164 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 126207791 Common dusC tRNA-dihydrouridine synthase C APL_0307 208 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 126207871 Common kpsF arabinose-5-phosphate isomerase APL_0387 175 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 126209306 Common cysN sulphate adenylate transferase subunit 1 APL_1844 157 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 126209420 Common - hypothetical protein APL_1966 23 COG3089 COG3089, Uncharacterized protein conserved in bacteria Function unknown 126208249 Common lpdA dihydrolipoamide dehydrogenase APL_0771 240 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 126209125 Common - mannose permease IIC component APL_1661 37 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 126208921 Common aqpZ aquaporin Z APL_1457 123 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 126208242 Common - hypothetical protein APL_0764 92 COG0391 COG0391, Uncharacterized conserved protein Function unknown 126208776 Common cysQ CysQ-like protein APL_1312 190 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 126208400 Common fdx 2Fe-2S ferredoxin APL_0924 112 COG0633 Fdx, Ferredoxin Energy production and conversion 126208903 Common ubiD 3-octaprenyl-4-hydroxybenzoate carboxy-lyase APL_1439 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 126207989 Common - putative endolysin APL_0505 41 COG3772 COG3772, Phage-related lysozyme (muraminidase) General function prediction only 126208044 Common - hypothetical protein APL_0562 80 COG0433 COG0433, Predicted ATPase General function prediction only 126209069 Common - hypothetical protein APL_1605 35 COG3681 COG3681, Uncharacterized conserved protein Function unknown 126208007 Common - putative phage tail assembly protein APL_0523 6 COG4723 COG4723, Phage-related protein, tail component Function unknown 126208544 Common - Maf-like protein APL_1072 196 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 126208662 Common - type I restriction-modification system, M subunit APL_1194 157 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 126208584 Common rumB 23S rRNA metyluridine methyltransferase APL_1112 158 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 126207494 Common ompP2A outer membrane protein P2 APL_0006 8 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 126208492 Common eda keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase APL_1018 126 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 126207758 Common - hypothetical protein APL_0270 36 COG2606 EbsC, Uncharacterized conserved protein Function unknown 126207599 Common - hypothetical protein APL_0111 33 COG3079 COG3079, Uncharacterized protein conserved in bacteria Function unknown 126208103 Common - putative M22-like peptidase APL_0621 206 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 126207925 Common metX homoserine O-acetyltransferase APL_0441 133 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 126209372 Common xylR xylose operon regulatory protein APL_1912 85 COG1609 PurR, Transcriptional regulators Transcription 126208218 Common - hypothetical protein APL_0738 11 COG3771 COG3771, Predicted membrane protein Function unknown 126207607 Common proQ putative solute/DNA competence effector APL_0119 27 COG3109 ProQ, Activator of osmoprotectant transporter ProP Signal transduction mechanisms 126208846 Common - hypothetical protein APL_1382 22 COG3171 COG3171, Uncharacterized protein conserved in bacteria Function unknown 126207803 Common - hypothetical protein APL_0319 56 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 126209198 Pathogen - hypothetical protein APL_1734 1 COG1480 COG1480, Predicted membrane-associated HD superfamily hydrolase General function prediction only 126208268 Common - hypothetical protein APL_0792 18 COG2315 MmcQ, Uncharacterized protein conserved in bacteria Function unknown 126208938 Common dnaG DNA primase APL_1474 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 126208074 Common guaA bifunctional GMP synthase/glutamine amidotransferase protein APL_0592 238 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 126209155 Common - putative ABC transporter, permease protein, amino acid APL_1691 176 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 126209142 Common - putative ferredoxin APL_1678 91 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 126208563 Common aspA aspartate ammonia-lyase APL_1091 224 COG1027 AspA, Aspartate ammonia-lyase Amino acid transport and metabolism 126207691 Common pgpA phosphatidylglycerophosphatase A APL_0203 99 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 126209143 Common - putative transcriptional regulator APL_1679 12 COG1476 COG1476, Predicted transcriptional regulators Transcription 126208860 Common - hypothetical protein APL_1396 3 None None None 126208655 Common - hypothetical protein APL_1187 24 COG4922 COG4922, Uncharacterized protein conserved in bacteria Function unknown 126208965 Common - transposase APL_1501 144 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 126207676 Common sixA possible phosphohistidine phosphatase APL_0188 45 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 126208913 Common mpl UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase APL_1449 207 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 126208577 Common dnaE DNA polymerase III subunit alpha APL_1105 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 126208552 Common metK S-adenosylmethionine synthetase APL_1080 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 126208079 Common tyrP-B tyrosine-specific transport protein 2 APL_0597 31 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 126208175 Common - hypothetical protein APL_0695 48 COG1444 COG1444, Predicted P-loop ATPase fused to an acetyltransferase General function prediction only 126208856 Common ptnC mannose permease IIC component APL_1392 38 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 126207975 Pathogen - hypothetical protein APL_0491 2 None None None 126209105 Common - hypothetical protein APL_1641 48 COG2964 COG2964, Uncharacterized protein conserved in bacteria Function unknown 126209379 Common - hypothetical protein APL_1919 52 COG0676 COG0676, Uncharacterized enzymes related to aldose 1-epimerase Carbohydrate transport and metabolism 126209356 Common - hypothetical protein APL_1896 137 COG0730 COG0730, Predicted permeases General function prediction only 126208692 Common - hypothetical protein APL_1224 25 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 126209385 Common tpiA triosephosphate isomerase APL_1925 222 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 126209187 Common - hypothetical protein APL_1723 52 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 126209250 Common rpsP 30S ribosomal protein S16 APL_1786 211 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 126207638 Common nqrA Na(+)-translocating NADH-quinone reductase subunit A APL_0150 44 COG1726 NqrA, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA Energy production and conversion 126207748 Common modC molybdate transporter ATP-binding protein APL_0260 249 COG4148 ModC, ABC-type molybdate transport system, ATPase component Inorganic ion transport and metabolism 126208379 Common folE GTP cyclohydrolase I APL_0903 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 126209241 Common rpmD 50S ribosomal protein L30 APL_1777 137 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 126209480 Common hisA 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase APL_2026 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 126209227 Common rplB 50S ribosomal protein L2 APL_1763 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 126207792 Common - hypothetical protein APL_0308 46 COG3768 COG3768, Predicted membrane protein Function unknown 126207540 Common - hypothetical protein APL_0052 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 126207543 Common rph ribonuclease PH APL_0055 201 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 126208397 Common - hypothetical protein APL_0921 13 None None None 126208239 Common - hypothetical protein APL_0761 19 COG3036 COG3036, Uncharacterized protein conserved in bacteria Function unknown 126209341 Common - hypothetical protein APL_1881 23 COG0439 AccC, Biotin carboxylase Lipid metabolism 126208613 Common recA recombinase A APL_1143 214 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 126208200 Common - hypothetical protein APL_0720 25 COG3103 COG3103, SH3 domain protein Signal transduction mechanisms 126209052 Common - predicted TRAP transporter solute receptor APL_1588 85 COG2358 Imp, TRAP-type uncharacterized transport system, periplasmic component General function prediction only 126208253 Common prsA ribose-phosphate pyrophosphokinase APL_0775 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 126207851 Common grpE heat shock protein (HSP-70 cofactor) APL_0367 225 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 126209243 Common secY preprotein translocase subunit SecY APL_1779 237 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 126207631 Common - putative acylphosphatase APL_0143 115 COG1254 AcyP, Acylphosphatases Energy production and conversion 126208782 Common arcC carbamate kinase APL_1318 65 COG0549 ArcC, Carbamate kinase Amino acid transport and metabolism 126208333 Common sdaA L-serine dehydratase APL_0857 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 126207550 Common mipB transaldolase B APL_0062 183 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 126209166 Common ulaR HTH-type transcriptional regulator ulaR APL_1702 115 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 126207913 Common - nucleoid-associated protein NdpA APL_0429 31 COG3081 COG3081, Nucleoid-associated protein General function prediction only 126208817 Common artI arginine-binding periplasmic protein precursor APL_1353 177 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 126209261 Common torD chaperone protein TorD APL_1797 13 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 126208685 Common - hypothetical protein APL_1217 56 COG3008 PqiB, Paraquat-inducible protein B General function prediction only 126208015 Common thiF predicted dinucleotide-utilizing enzyme involved in molybdopterin and thiamine biosynthesis APL_0533 191 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 126208117 Pathogen - hypothetical protein APL_0635 2 None None None 126207665 Common folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase APL_0177 200 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 126209317 Common - hypothetical protein APL_1855 29 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 126209274 Common - Putative Mg-dependent DNAse APL_1810 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 126207537 Pathogen - hypothetical protein APL_0049 2 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 126207822 Common - hypothetical protein APL_0338 25 COG3117 COG3117, Uncharacterized protein conserved in bacteria Function unknown 126207693 Common - predicted rRNA methyltransferase APL_0205 75 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 126208136 Common hlyX fumarate/nitrate reduction transcriptional regulator APL_0656 160 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 126208131 Common galU UTP--glucose-1-phosphate uridylyltransferase APL_0651 229 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 126208633 Common trpD anthranilate phosphoribosyltransferase APL_1165 218 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 126208731 Common copA copper-transporting P-type ATPase APL_1265 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 126208734 Common sppA protease 4 APL_1268 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 126207559 Common - hypothetical protein APL_0071 92 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 126209416 Common hflX GTP-binding protein hflX APL_1962 222 COG2262 HflX, GTPases General function prediction only 126208391 Common cca multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase APL_0915 195 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 126209278 Common holB DNA polymerase III subunit delta' APL_1816 215 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 126208187 Common - hypothetical protein APL_0707 24 COG2731 EbgC, Beta-galactosidase, beta subunit Carbohydrate transport and metabolism 126208951 Common sufI protein SufI precursor APL_1487 71 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 126208409 Common ompP1 putative outer membrane protein precursor APL_0933 66 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 126208526 Common cyaA adenylate cyclase APL_1054 25 COG3072 CyaA, Adenylate cyclase Nucleotide transport and metabolism 126208055 Common pdxT glutamine amidotransferase subunit PdxT APL_0573 90 COG0311 PDX2, Predicted glutamine amidotransferase involved in pyridoxine biosynthesis Coenzyme metabolism 126208827 Common - hypothetical protein APL_1363 116 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 126209339 Common rluC 23S rRNA pseudouridylate synthase C APL_1877 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 126208062 Common mukE condesin subunit E APL_0580 20 COG3095 MukE, Uncharacterized protein involved in chromosome partitioning Cell division and chromosome partitioning 126208324 Common - putative ABC transporter periplasmic binding protein APL_0848 201 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 126207959 Common trpR Trp operon repressor APL_0475 22 COG2973 TrpR, Trp operon repressor Transcription 126207680 Common dam DNA adenine methylase APL_0192 98 COG0338 Dam, Site-specific DNA methylase DNA replication, recombination, and repair 126208381 Common - hypothetical protein APL_0905 4 COG4925 COG4925, Uncharacterized conserved protein Function unknown 126207888 Common hemA glutamyl-tRNA reductase APL_0404 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 126208317 Common pntB pyridine nucleotide transhydrogenase APL_0841 123 COG1282 PntB, NAD/NADP transhydrogenase beta subunit Energy production and conversion 126209047 Common cpxC capsule polysaccharide export inner-membrane protein APL_1583 35 COG3524 KpsE, Capsule polysaccharide export protein Cell envelope biogenesis, outer membrane 126209098 Common - putative glycosyltransferase APL_1634 3 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 126207711 Common infC translation initiation factor IF-3 APL_0223 211 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 126208744 Common lpxK tetraacyldisaccharide 4'-kinase APL_1278 129 COG1663 LpxK, Tetraacyldisaccharide-1-P 4'-kinase Cell envelope biogenesis, outer membrane 126208824 Common - hypothetical protein APL_1360 31 COG3101 COG3101, Uncharacterized protein conserved in bacteria Function unknown 126209273 Common - hypothetical protein APL_1809 15 None None None 126208343 Common smpB SsrA-binding protein APL_0867 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 126208622 Common - hypothetical protein APL_1152 3 None None None 126209231 Common rplP 50S ribosomal protein L16 APL_1767 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 126208096 Common bioD dithiobiotin synthetase APL_0614 138 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 126208261 Common ssb single-strand DNA-binding protein APL_0783 213 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 126208443 Common glnE glutamate-ammonia-ligase adenylyltransferase APL_0969 119 COG1391 GlnE, Glutamine synthetase adenylyltransferase Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms 126208276 Common pckA phosphoenolpyruvate carboxykinase APL_0800 98 COG1866 PckA, Phosphoenolpyruvate carboxykinase (ATP) Energy production and conversion 126207763 Common pgsA phosphatidylglycerophosphate synthase APL_0275 194 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 126208927 Common - putative ABC-transporter APL_1463 112 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 126209348 Pathogen pulG hypothetical protein APL_1888 3 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 126209124 Common - mannose permease IID component APL_1660 40 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 126208023 Common lepA GTP-binding protein LepA APL_0541 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 126207689 Common nusB transcription antitermination protein NusB APL_0201 182 COG0781 NusB, Transcription termination factor Transcription 126209328 Common mobAB MobAB fusion protein APL_1866 137 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 126207858 Common glpF glycerol uptake facilitator protein APL_0374 132 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 126208530 Common - transposase APL_1058 37 None None None 126208837 Common - DNA replication initiation factor APL_1373 198 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 126208197 Common - iron(III) ABC transporter, ATP-binding protein APL_0717 249 COG4604 CeuD, ABC-type enterochelin transport system, ATPase component Inorganic ion transport and metabolism 126207625 Common - hypothetical protein APL_0137 6 COG5413 COG5413, Uncharacterized integral membrane protein Function unknown 126207506 Common murG N-acetylglucosaminyl transferase APL_0018 208 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 126209303 Common murI glutamate racemase APL_1841 192 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 126208110 Pathogen - hypothetical protein APL_0628 2 None None None 126208741 Common gltX glutamyl-tRNA synthetase APL_1275 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 126207507 Common murC UDP-N-acetylmuramate--L-alanine ligase APL_0019 209 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 126209014 Common wecD TDP-fucosamine acetyltransferase APL_1550 18 COG0456 RimI, Acetyltransferases General function prediction only 126208408 Common - putative HTH-type transcriptional regulator APL_0932 173 COG1959 COG1959, Predicted transcriptional regulator Transcription 126208752 Common murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase APL_1286 218 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 126208802 Common hybF putative hydrogenase nickel incorporation protein HybF APL_1338 90 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 126208168 Common torZ trimethylamine-N-oxide reductase precursor APL_0688 180 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 126207709 Common - hypothetical protein APL_0221 20 COG4259 COG4259, Uncharacterized protein conserved in bacteria Function unknown 126209334 Common - putative D-alanyl-D-alanine carboxypeptidase APL_1872 38 COG1876 VanY, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 126207659 Common rnfE SoxR-reducing system protein RsxE APL_0171 76 COG4660 RnfE, Predicted NADH:ubiquinone oxidoreductase, subunit RnfE Energy production and conversion 126208147 Common uvrB excinuclease ABC subunit B APL_0667 229 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 126209444 Common mutM formamidopyrimidine-DNA glycosylase APL_1990 182 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 126208477 Common ppiD peptidyl-prolyl cis-trans isomerase D APL_1003 172 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 126209001 Common prmA ribosomal protein L11 methyltransferase APL_1537 174 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 126207673 Common aroF phospho-2-dehydro-3-deoxyheptonate aldolase APL_0185 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 126208479 Common rpsO 30S ribosomal protein S15 APL_1005 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 126208833 Common ccmD heme exporter protein D APL_1369 10 COG3114 CcmD, Heme exporter protein D Intracellular trafficking and secretion 126207952 Common - probable NADP-dependent dehydrogenase APL_0468 224 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 126207617 Common rnhB ribonuclease HII APL_0129 215 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 126209066 Common mutS DNA mismatch repair protein APL_1602 203 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 126208665 Common - 3-hydroxyacid dehydrogenase APL_1197 180 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 126207906 Common argG argininosuccinate synthase APL_0422 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 126208349 Common rlpB putative rare lipoprotein B APL_0873 23 COG2980 RlpB, Rare lipoprotein B Cell envelope biogenesis, outer membrane 126207937 Common - hypothetical protein APL_0453 19 COG2990 VirK, Uncharacterized protein conserved in bacteria Function unknown 126207789 Common - hypothetical protein APL_0305 96 None None None 126207920 Common mreC rod shape-determining protein MreC APL_0436 150 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 126208642 Common - hypothetical protein APL_1174 61 COG2976 COG2976, Uncharacterized protein conserved in bacteria Function unknown 126208384 Common - putative transcriptional regulator APL_0908 187 COG0583 LysR, Transcriptional regulator Transcription 126208161 Common - putative soluble lytic murein transglycosylase precursor APL_0681 150 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 126209082 Common ureA urease subunit gamma APL_1618 96 COG0831 UreA, Urea amidohydrolase (urease) gamma subunit Amino acid transport and metabolism 126209068 Common - hypothetical amino-acid ABC transporter permease protein APL_1604 174 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 126209408 Common rbn ribonuclease BN APL_1950 156 COG1295 Rbn, Predicted membrane protein Function unknown 126208353 Pathogen apfD fimbrial leader peptidase APL_0877 3 None None None 126208254 Common ispE 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase APL_0776 193 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 126207527 Common argS arginyl-tRNA synthetase APL_0039 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126209287 Common spoT Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (ppGpp)ase) APL_1825 207 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 126208541 Common ftnA ferritin-like protein 1 APL_1069 83 COG1528 Ftn, Ferritin-like protein Inorganic ion transport and metabolism 126207824 Common - hypothetical protein APL_0340 88 COG1512 COG1512, Beta-propeller domains of methanol dehydrogenase type General function prediction only 126207968 Common rimK ribosomal protein S6 modification protein APL_0484 141 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 126209053 Common - hypothetical protein APL_1589 130 COG1739 COG1739, Uncharacterized conserved protein Function unknown 126208712 Common - hypothetical protein APL_1246 92 COG0778 NfnB, Nitroreductase Energy production and conversion 126207947 Common - predicted sortase and related acyltransferases APL_0463 88 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 126209460 Common holD DNA polymerase III subunit psi APL_2006 5 COG3050 HolD, DNA polymerase III, psi subunit DNA replication, recombination, and repair 126207747 Common - predicted oligoketide cyclase/lipid transport protein APL_0259 104 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 126208068 Common - putative RND efflux membrane fusion protein APL_0586 173 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 126207867 Common ribE riboflavin synthase subunit alpha APL_0383 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 126209130 Common gntK thermosensitive gluconokinase APL_1666 80 COG3265 GntK, Gluconate kinase Carbohydrate transport and metabolism 126207719 Common - Holliday junction resolvase-like protein APL_0231 180 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 126207771 Common ruvA Holliday junction DNA helicase motor protein APL_0283 211 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 126209129 Common gntP_1 gluconate permease APL_1665 76 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 126207945 Common - Predicted hydrolases of the HAD superfamily APL_0461 128 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 126208601 Common - hypothetical protein APL_1131 25 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 126207834 Common glgP glycogen phosphorylase APL_0350 137 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 126208870 Common comEA DNA uptake protein APL_1406 97 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 126207701 Common - hypothetical protein APL_0213 17 COG1203 COG1203, Predicted helicases General function prediction only 126208056 Common - tRNA-specific adenosine deaminase APL_0574 215 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 126208156 Common - hypothetical protein APL_0676 126 COG1509 KamA, Lysine 2,3-aminomutase Amino acid transport and metabolism 126207963 Pathogen - hypothetical protein APL_0479 1 None None None 126207592 Common - autotransporter adhesin APL_0104 142 COG5295 Hia, Autotransporter adhesin Intracellular trafficking and secretion / Extracellular structures 126209467 Common fhuC Ferrichrome transport ATP-binding protein fhuC APL_2013 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 126209004 Common tldD TldD-like protein APL_1540 170 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 126208551 Common - putative purine permease APL_1079 127 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 126208922 Common - hypothetical protein APL_1458 23 COG3471 COG3471, Predicted periplasmic/secreted protein Function unknown 126208816 Common artQ arginine transporter permease subunit ArtQ APL_1352 175 COG4215 ArtQ, ABC-type arginine transport system, permease component Amino acid transport and metabolism 126208610 Common - hypothetical protein APL_1140 176 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 126209487 Common scrB Sucrose-6-phosphate hydrolase (Sucrase) (Invertase) APL_2033 50 COG1621 SacC, Beta-fructosidases (levanase/invertase) Carbohydrate transport and metabolism 126208190 Common lysC aspartate kinase III APL_0710 235 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 126208225 Common mepA penicillin-insensitive murein endopeptidase APL_0747 40 COG3770 MepA, Murein endopeptidase Cell envelope biogenesis, outer membrane 126208427 Common - hypothetical protein APL_0951 4 None None None 126208758 Common - predicted ABC transporter ATP-binding protein APL_1292 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 126209190 Pathogen - hypothetical protein APL_1726 1 None None None 126207805 Common dsbB disulfide bond formation protein B APL_0321 46 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 126208790 Common uvrD DNA-dependent helicase II APL_1326 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 126208562 Common arsR putative transcriptional regulator APL_1090 80 COG0640 ArsR, Predicted transcriptional regulators Transcription 126208416 Common - hypothetical protein APL_0940 15 COG2830 COG2830, Uncharacterized protein conserved in bacteria Function unknown 126208581 Common mutH DNA mismatch repair protein APL_1109 28 COG3066 MutH, DNA mismatch repair protein DNA replication, recombination, and repair 126207870 Common greB transcription elongation factor GreB APL_0386 187 COG0782 GreA, Transcription elongation factor Transcription 126209457 Common ap2140 hypothetical protein APL_2003 113 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 126208022 Common thiE thiamine monophosphate synthase APL_0540 201 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 126208389 Common cysS cysteinyl-tRNA synthetase APL_0913 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 126207919 Common mreB rod shape-determining protein MreB APL_0435 235 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 126208310 Common udk uridine kinase APL_0834 83 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 126208649 Common kefB glutathione-regulated potassium-efflux system protein APL_1181 202 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 126208904 Common znuA high-affinity zinc transporter periplasmic component APL_1440 109 COG4531 ZnuA, ABC-type Zn2+ transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 126208775 Common zwf glucose-6-phosphate 1-dehydrogenase APL_1311 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 126209426 Common rpmG 50S ribosomal protein L33 APL_1972 140 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 126208372 Common fdhE formate dehydrogenase accessory protein FdhE APL_0896 40 COG3058 FdhE, Uncharacterized protein involved in formate dehydrogenase formation Posttranslational modification, protein turnover, chaperones 126207799 Common rluA ribosomal large subunit pseudouridine synthase A APL_0315 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 126208436 Common ostA organic solvent tolerance protein APL_0962 119 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 126208884 Common mglB D-galactose-binding periplasmic protein precursor APL_1420 97 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 126209182 Common rplK 50S ribosomal protein L11 APL_1718 247 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 126207585 Common ilvD dihydroxy-acid dehydratase APL_0097 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 126209035 Common tonB1 periplasmic protein APL_1571 2 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 126208463 Pathogen - transposase APL_0989 2 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 126207873 Common ompP4 lipoprotein E precursor APL_0389 25 COG2503 COG2503, Predicted secreted acid phosphatase General function prediction only 126209199 Common hslU ATP-dependent protease ATP-binding subunit APL_1735 212 COG1220 HslU, ATP-dependent protease HslVU (ClpYQ), ATPase subunit Posttranslational modification, protein turnover, chaperones 126207815 Pathogen hlp putative lipoprotein APL_0331 3 COG4982 COG4982, 3-oxoacyl- acyl-carrier protein 126208523 Common nrfX disulfide bound formation protein E (dsbE) APL_1051 105 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 126208941 Common - hypothetical protein APL_1477 3 None None None 126208507 Common pheA P-protein APL_1033 214 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 126209364 Common - hypothetical protein APL_1904 6 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 126207492 Common sodC superoxide dismutase [Cu-Zn] precursor APL_0004 85 COG2032 SodC, Cu/Zn superoxide dismutase Inorganic ion transport and metabolism 126208211 Common - hypothetical protein APL_0731 17 COG3094 COG3094, Uncharacterized protein conserved in bacteria Function unknown 126208450 Common - hypothetical protein APL_0976 32 COG2056 COG2056, Predicted permease General function prediction only 126209115 Common atpE F0F1 ATP synthase subunit C APL_1651 125 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 126208180 Common hisC histidinol-phosphate aminotransferase APL_0700 238 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 126208424 Common - transposase APL_0948 54 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 126208699 Common malT HTH-type transcriptional regulator MalT APL_1233 89 COG2909 MalT, ATP-dependent transcriptional regulator Transcription 126209025 Common selB selenocysteine-specific elongation factor APL_1561 249 COG3276 SelB, Selenocysteine-specific translation elongation factor Translation, ribosomal structure and biogenesis 126208001 Common - hypothetical protein APL_0517 1 None None None 126208894 Common napD putative napD protein APL_1430 18 COG3062 NapD, Uncharacterized protein involved in formation of periplasmic nitrate reductase Inorganic ion transport and metabolism 126208937 Common rpsU 30S ribosomal protein S21 APL_1473 126 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 126207574 Common - hypothetical protein APL_0086 33 COG3753 COG3753, Uncharacterized protein conserved in bacteria Function unknown 126208674 Common - plasmid stability-like protein APL_1206 51 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 126209177 Common - hypothetical protein APL_1713 43 COG1297 COG1297, Predicted membrane protein Function unknown 126208032 Common tadC tight adherence protein C APL_0550 34 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion