Thermofilum pendens Hrk 5, complete genome NC_008698 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 119719162 Common rpl24p 50S ribosomal protein L24P Tpen_0244 38 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 119719907 Nonpathogen - hypothetical protein Tpen_0999 3 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 119720513 Nonpathogen - transcriptional regulator, AbrB family Tpen_1610 8 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 119719330 Common - putative deoxyhypusine synthase Tpen_0413 61 COG1899 DYS1, Deoxyhypusine synthase Posttranslational modification, protein turnover, chaperones 119719621 Nonpathogen - putative transcriptional regulator, RpiR family Tpen_0711 2 COG1737 RpiR, Transcriptional regulators Transcription 119720319 Nonpathogen - PaREP8 domain containing protein Tpen_1414 4 None None None 119719534 Nonpathogen - putative DNA primase, small subunit Tpen_0622 32 COG1467 PRI1, Eukaryotic-type DNA primase, catalytic (small) subunit DNA replication, recombination, and repair 119719339 Nonpathogen - ribosomal protein S6e Tpen_0422 32 COG2125 RPS6A, Ribosomal protein S6E (S10) Translation, ribosomal structure and biogenesis 119719221 Nonpathogen - hypothetical protein Tpen_0303 2 None None None 119719399 Nonpathogen - hypothetical protein Tpen_0482 5 None None None 119720310 Nonpathogen - hypothetical protein Tpen_1405 2 None None None 119719853 Common - PEBP family protein Tpen_0945 128 COG1881 COG1881, Phospholipid-binding protein General function prediction only 119720727 Common - dihydrolipoamide dehydrogenase Tpen_1824 235 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 119720351 Nonpathogen - ABC-2 type transporter Tpen_1446 2 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 119719498 Nonpathogen - protein of unknown function, ATP binding Tpen_0585 15 COG1100 COG1100, GTPase SAR1 and related small G proteins General function prediction only 119719748 Nonpathogen - Xylose isomerase domain protein TIM barrel Tpen_0839 4 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 119720101 Common - LmbE family protein Tpen_1195 82 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 119719050 Common - membrane protein-like Tpen_0132 15 COG1470 COG1470, Predicted membrane protein Function unknown 119720359 Common - alpha amylase, catalytic region Tpen_1454 152 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 119719403 Nonpathogen - ribosomal protein L29 Tpen_0487 2 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 119719276 Nonpathogen - Ribonucleoprotein complex SRP, Srp19 component Tpen_0359 27 COG1400 SEC65, Signal recognition particle 19 kDa protein Intracellular trafficking and secretion 119720614 Nonpathogen - hypothetical protein Tpen_1711 1 None None None 119720654 Common - ABC transporter related Tpen_1751 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 119720127 Nonpathogen - zinc finger, RanBP2-type Tpen_1221 1 None None None 119719021 Common - methionyl-tRNA synthetase, beta subunit Tpen_0103 184 COG0073 ARC1, EMAP domain General function prediction only 119719548 Nonpathogen - hypothetical protein Tpen_0637 1 None None None 119719522 Common - putative endoribonuclease L-PSP Tpen_0610 191 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 119720152 Common - binding-protein-dependent transport systems inner membrane component Tpen_1246 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 119719094 Common - Aldehyde ferredoxin oxidoreductase Tpen_0176 59 COG2414 COG2414, Aldehyde:ferredoxin oxidoreductase Energy production and conversion 119719551 Nonpathogen - Oligosaccharyl transferase, STT3 subunit Tpen_0640 13 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 119719637 Common - type II secretion system protein E Tpen_0727 29 COG0630 VirB11, Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis Cell motility and secretion / Intracellular trafficking and secretion 119719800 Common - mevalonate kinase Tpen_0891 52 COG1577 ERG12, Mevalonate kinase Lipid metabolism 119719962 Common - molybdenum cofactor synthesis domain Tpen_1054 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 119720235 Nonpathogen - hypothetical protein Tpen_1330 1 None None None 119720615 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Tpen_1712 166 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 119719123 Common - glycosyl transferase, family 2 Tpen_0205 159 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 119719059 Common - HhH-GPD family protein Tpen_0141 237 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 119719671 Nonpathogen - hypothetical protein Tpen_0761 4 None None None 119719993 Common - proton-translocating NADH-quinone oxidoreductase, chain M Tpen_1086 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 119719159 Nonpathogen rps14P 30S ribosomal protein S14P Tpen_0241 33 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 119718998 Common - small GTP-binding protein Tpen_0080 12 COG1100 COG1100, GTPase SAR1 and related small G proteins General function prediction only 119719487 Common - thiamine pyrophosphate enzyme domain protein TPP-binding Tpen_0574 107 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 119719673 Common - deoxyribose-phosphate aldolase Tpen_0763 137 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 119719882 Common - FeoA family protein Tpen_0974 61 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 119718920 Common - Cellulase Tpen_0002 90 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 119719067 Common - solute binding protein-like protein Tpen_0149 19 COG3889 COG3889, Predicted solute binding protein General function prediction only 119720696 Common - ABC-type tungstate transport system permease component-like Tpen_1793 62 COG2998 TupB, ABC-type tungstate transport system, permease component Coenzyme metabolism 119719593 Common - protein of unknown function DUF355 Tpen_0683 33 COG1839 COG1839, Uncharacterized conserved protein Function unknown 119720178 Nonpathogen - CRISPR-associated protein, MJ1666 family Tpen_1272 3 COG1517 COG1517, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 119719946 Common - L-lactate permease-like Tpen_1038 70 COG1620 LldP, L-lactate permease Energy production and conversion 119720024 Nonpathogen - metallophosphoesterase Tpen_1118 1 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 119719455 Common - pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit Tpen_0541 77 COG1144 COG1144, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit Energy production and conversion 119719285 Nonpathogen - tRNA adenylyltransferase Tpen_0368 34 COG1746 CCA1, tRNA nucleotidyltransferase (CCA-adding enzyme) Translation, ribosomal structure and biogenesis 119719519 Common - Geranyltranstransferase Tpen_0606 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 119720056 Common - binding-protein-dependent transport systems inner membrane component Tpen_1150 154 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 119720144 Nonpathogen - hypothetical protein Tpen_1238 1 None None None 119720706 Common - hypothetical protein Tpen_1803 39 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 119719460 Nonpathogen rpl10e 50S ribosomal protein L10e Tpen_0546 34 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 119719795 Nonpathogen - protein of unknown function DUF437 Tpen_0886 11 COG2411 COG2411, Uncharacterized conserved protein Function unknown 119720333 Nonpathogen - cytochrome c biogenesis protein, transmembrane region Tpen_1428 5 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 119720228 Nonpathogen - DEAD/DEAH box helicase domain protein Tpen_1323 2 COG1203 COG1203, Predicted helicases General function prediction only 119719660 Common - ATP-dependent DNA ligase Tpen_0750 110 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 119719686 Nonpathogen - helix-turn-helix domain protein Tpen_0776 29 COG1709 COG1709, Predicted transcriptional regulator Transcription 119720294 Nonpathogen - hypothetical protein Tpen_1389 5 None None None 119720525 Common - carbohydrate kinase, FGGY Tpen_1622 185 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 119719543 Nonpathogen - hypothetical protein Tpen_0631 1 None None None 119719012 Common - Aldehyde ferredoxin oxidoreductase Tpen_0094 59 COG2414 COG2414, Aldehyde:ferredoxin oxidoreductase Energy production and conversion 119720449 Common - cobalt transport protein Tpen_1545 55 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 119720171 Common - hypothetical protein Tpen_1265 20 COG1892 COG1892, Uncharacterized protein conserved in archaea Function unknown 119719669 Nonpathogen - hypothetical protein Tpen_0759 3 COG0170 SEC59, Dolichol kinase Lipid metabolism 119719461 Nonpathogen - hypothetical protein Tpen_0547 9 COG4879 COG4879, Uncharacterized protein conserved in archaea Function unknown 119719146 Common - Ribosomal protein L25/L23 Tpen_0228 154 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 119719529 Common - adenosylhomocysteinase Tpen_0617 178 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 119719234 Common - ribose-phosphate pyrophosphokinase Tpen_0317 243 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 119720632 Common - hypothetical protein Tpen_1729 9 COG1470 COG1470, Predicted membrane protein Function unknown 119719956 Nonpathogen - transcription regulator, MarR family Tpen_1048 4 COG1510 COG1510, Predicted transcriptional regulators Transcription 119720109 Common - Citrate transporter Tpen_1203 127 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 119719108 Common - formate dehydrogenase, alpha subunit Tpen_0190 203 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 119719565 Nonpathogen - hypothetical protein Tpen_0655 1 None None None 119719916 Nonpathogen - DNA polymerase, beta domain protein region Tpen_1008 2 None None None 119720010 Nonpathogen - hypothetical protein Tpen_1103 2 None None None 119719699 Nonpathogen - hypothetical protein Tpen_0789 1 None None None 119719219 Nonpathogen - hypothetical protein Tpen_0301 19 COG2090 COG2090, Uncharacterized protein conserved in archaea Function unknown 119719429 Nonpathogen rps15p 30S ribosomal protein S15P Tpen_0515 34 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 119719152 Nonpathogen rpl15p 50S ribosomal protein L15P Tpen_0234 35 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 119719816 Nonpathogen - hypothetical protein Tpen_0907 6 None None None 119720195 Nonpathogen - hypothetical protein Tpen_1289 4 COG1337 COG1337, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 119719771 Common - TIP49-like Tpen_0862 20 COG1224 TIP49, DNA helicase TIP49, TBP-interacting protein Transcription 119720451 Common - ABC transporter related Tpen_1547 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 119720582 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Tpen_1679 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 119719349 Nonpathogen - hypothetical protein Tpen_0432 1 None None None 119719723 Nonpathogen - hypothetical protein Tpen_0814 1 None None None 119719116 Nonpathogen - protein of unknown function DUF75 Tpen_0198 28 COG2047 COG2047, Uncharacterized protein (ATP-grasp superfamily) General function prediction only 119719387 Nonpathogen - 30S ribosomal protein S19e Tpen_0470 34 COG2238 RPS19A, Ribosomal protein S19E (S16A) Translation, ribosomal structure and biogenesis 119719923 Nonpathogen - hypothetical protein Tpen_1015 1 None None None 119719868 Nonpathogen - hypothetical protein Tpen_0960 2 None None None 119719619 Nonpathogen - protein of unknown function DUF127 Tpen_0709 31 COG1303 COG1303, Uncharacterized protein conserved in archaea Function unknown 119718991 Common - Radical SAM domain protein Tpen_0073 66 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 119720639 Common - protein of unknown function DUF86 Tpen_1736 31 COG2445 COG2445, Uncharacterized conserved protein Function unknown 119720645 Common - ABC transporter related Tpen_1742 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 119719186 Common - 30S ribosomal protein S7P Tpen_0268 240 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 119719931 Nonpathogen - Rad51-like Tpen_1023 34 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 119719888 Nonpathogen - hypothetical protein Tpen_0980 1 None None None 119720729 Common - Glycosyltransferases probably involved in cell wall biogenesis-like Tpen_1826 33 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 119720097 Common - protein of unknown function DUF763 Tpen_1191 32 COG1415 COG1415, Uncharacterized conserved protein Function unknown 119720628 Nonpathogen - glycosyl transferase, group 1 Tpen_1725 20 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 119720066 Common - oxidoreductase FAD/NAD(P)-binding domain protein Tpen_1160 85 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 119719005 Common - glycosyl transferase, family 2 Tpen_0087 76 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 119720285 Nonpathogen - hypothetical protein Tpen_1380 4 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 119719257 Nonpathogen - V-type ATPase, D subunit Tpen_0340 16 COG1394 NtpD, Archaeal/vacuolar-type H+-ATPase subunit D Energy production and conversion 119719896 Nonpathogen - hypothetical protein Tpen_0988 1 None None None 119719902 Nonpathogen - hypothetical protein Tpen_0994 1 None None None 119720135 Nonpathogen - hypothetical protein Tpen_1229 1 None None None 119719224 Common - Proteasome endopeptidase complex Tpen_0307 48 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 119718934 Nonpathogen - hypothetical protein Tpen_0016 1 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 119720116 Common - ABC transporter related Tpen_1210 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 119720211 Nonpathogen - hypothetical protein Tpen_1305 1 None None None 119719561 Nonpathogen - nucleotidyltransferase of the DNA polymerase beta superfamily Tpen_0651 12 COG2413 COG2413, Predicted nucleotidyltransferase General function prediction only 119719045 Nonpathogen - hypothetical protein Tpen_0127 3 COG0622 COG0622, Predicted phosphoesterase General function prediction only 119719422 Nonpathogen - hypothetical protein Tpen_0507 1 None None None 119720503 Nonpathogen - phosphate uptake regulator, PhoU Tpen_1600 26 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 119720017 Common - glycoside hydrolase, family 1 Tpen_1110 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 119719765 Common - 2-oxoacid ferredoxin oxidoreductase subunit beta Tpen_0856 118 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 119719324 Common - ornithine carbamoyltransferase Tpen_0407 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 119719325 Common - seryl-tRNA synthetase Tpen_0408 243 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 119720327 Nonpathogen - DNA polymerase, beta domain protein region Tpen_1422 22 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 119719763 Common - protein of unknown function DUF91 Tpen_0854 37 COG1637 COG1637, Predicted nuclease of the RecB family DNA replication, recombination, and repair 119719106 Common - NADH dehydrogenase (quinone) Tpen_0188 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 119720472 Nonpathogen - hypothetical protein Tpen_1569 2 None None None 119720034 Common - glycerol kinase Tpen_1128 178 COG0554 GlpK, Glycerol kinase Energy production and conversion 119718953 Nonpathogen - hypothetical protein Tpen_0035 1 COG1378 COG1378, Predicted transcriptional regulators Transcription 119720580 Common - binding-protein-dependent transport systems inner membrane component Tpen_1677 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 119719474 Nonpathogen - RNAse P, Rpr2/Rpp21 subunit Tpen_0560 21 COG2023 RPR2, RNase P subunit RPR2 Translation, ribosomal structure and biogenesis 119719982 Nonpathogen - NADH-ubiquinone oxidoreductase, chain 4L Tpen_1075 1 None None None 119718950 Nonpathogen - metallopeptidase-like Tpen_0032 7 COG4900 COG4900, Predicted metallopeptidase General function prediction only 119720246 Nonpathogen - hypothetical protein Tpen_1341 1 None None None 119720360 Common - pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit Tpen_1455 110 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 119719733 Common - GTP-binding protein, HSR1-related Tpen_0824 105 COG1161 COG1161, Predicted GTPases General function prediction only 119720673 Common - short-chain dehydrogenase/reductase SDR Tpen_1770 229 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 119720405 Common - hypothetical protein Tpen_1500 8 None None None 119720369 Nonpathogen - transcriptional regulator, PadR-like family Tpen_1464 5 COG1695 COG1695, Predicted transcriptional regulators Transcription 119719007 Nonpathogen - hypothetical protein Tpen_0089 3 None None None 119719716 Common - hypothetical protein Tpen_0807 5 None None None 119720002 Nonpathogen - hypothetical protein Tpen_1095 5 None None None 119719738 Nonpathogen - protein of unknown function DUF92, transmembrane Tpen_0829 9 COG1836 COG1836, Predicted membrane protein Function unknown 119720719 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Tpen_1816 172 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 119719649 Common - protein of unknown function RIO1 Tpen_0739 66 COG0478 COG0478, RIO-like serine/threonine protein kinase fused to N-terminal HTH domain Signal transduction mechanisms 119719584 Nonpathogen - hypothetical protein Tpen_0674 1 None None None 119718979 Nonpathogen - methyltransferase FkbM family Tpen_0061 18 COG2520 COG2520, Predicted methyltransferase General function prediction only 119720379 Nonpathogen - ABC-2 type transporter Tpen_1474 6 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 119718969 Common - protein of unknown function DUF81 Tpen_0051 27 COG0730 COG0730, Predicted permeases General function prediction only 119719357 Nonpathogen - hypothetical protein Tpen_0440 1 None None None 119719193 Nonpathogen - hypothetical protein Tpen_0275 1 None None None 119720344 Nonpathogen - hypothetical protein Tpen_1439 9 None None None 119719806 Nonpathogen - transcriptional regulator, Fis family Tpen_0897 1 COG4372 COG4372, Uncharacterized protein conserved in bacteria with the myosin-like domain Function unknown 119720587 Common - cation diffusion facilitator family transporter Tpen_1684 196 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 119719226 Common - beta-lactamase domain protein Tpen_0309 164 COG1782 COG1782, Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain General function prediction only 119719595 Common - Pseudouridylate synthase Tpen_0685 87 COG0585 COG0585, Uncharacterized conserved protein Function unknown 119720572 Nonpathogen - magnesium-dependent phosphatase-1 Tpen_1669 8 COG4996 COG4996, Predicted phosphatase General function prediction only 119720599 Nonpathogen - PaREP8 domain containing protein Tpen_1696 6 None None None 119719707 Common - protein of unknown function DUF126 Tpen_0797 38 COG1786 COG1786, Uncharacterized conserved protein Function unknown 119719342 Common - Thioredoxin domain Tpen_0425 229 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 119720275 Nonpathogen - PaREP8 domain containing protein Tpen_1370 6 None None None 119719700 Nonpathogen - hypothetical protein Tpen_0790 1 None None None 119719205 Nonpathogen rpoH DNA-directed RNA polymerase subunit H Tpen_0287 33 COG2012 RPB5, DNA-directed RNA polymerase, subunit H, RpoH/RPB5 Transcription 119719279 Nonpathogen - 30S ribosomal protein S30e Tpen_0362 1 COG4919 COG4919, Ribosomal protein S30 Translation, ribosomal structure and biogenesis 119720578 Common - glycoside hydrolase, family 1 Tpen_1675 102 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 119719690 Nonpathogen - hypothetical protein Tpen_0780 3 None None None 119719651 Nonpathogen - Methyltransferase type 11 Tpen_0741 11 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 119720130 Nonpathogen - ABC-2 type transporter Tpen_1224 3 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 119718965 Common - phosphoribosyltransferase Tpen_0047 164 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 119719530 Common - 5'-methylthioadenosine phosphorylase II Tpen_0618 167 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 119719634 Nonpathogen - hypothetical protein Tpen_0724 1 None None None 119719443 Nonpathogen - hypothetical protein Tpen_0529 1 None None None 119718946 Nonpathogen - PilT protein domain protein Tpen_0028 8 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 119719015 Common - protein of unknown function UPF0153 Tpen_0097 20 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 119719640 Nonpathogen - hypothetical protein Tpen_0730 1 None None None 119720376 Common - hypothetical protein Tpen_1471 20 COG2014 COG2014, Uncharacterized conserved protein Function unknown 119719989 Common - respiratory-chain NADH dehydrogenase, subunit 1 Tpen_1082 188 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 119719999 Common - phosphoenolpyruvate-protein phosphotransferase Tpen_1092 223 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 119720592 Nonpathogen - DNA polymerase, beta domain protein region Tpen_1689 10 None None None 119720073 Common - glycerophosphoryl diester phosphodiesterase Tpen_1167 174 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 119720661 Nonpathogen - hypothetical protein Tpen_1758 2 None None None 119720414 Nonpathogen - transcriptional regulator, TrmB Tpen_1509 5 COG3398 COG3398, Uncharacterized protein conserved in archaea Function unknown 119719364 Nonpathogen - heat shock protein Hsp20 Tpen_0447 36 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 119719965 Common - binding-protein-dependent transport systems inner membrane component Tpen_1057 208 COG3833 MalG, ABC-type maltose transport systems, permease component Carbohydrate transport and metabolism 119719140 Nonpathogen rplP0 acidic ribosomal protein P0 Tpen_0222 36 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 119719236 Common - peptidase M28 Tpen_0319 41 COG2234 Iap, Predicted aminopeptidases General function prediction only 119719503 Nonpathogen - hypothetical protein Tpen_0590 3 None None None 119720042 Common - ABC transporter related Tpen_1136 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 119719080 Nonpathogen - hypothetical protein Tpen_0162 1 None None None 119720663 Common - Radical SAM domain protein Tpen_1760 45 COG0731 COG0731, Fe-S oxidoreductases Energy production and conversion 119720607 Nonpathogen - hypothetical protein Tpen_1704 2 None None None 119720686 Nonpathogen - hypothetical protein Tpen_1783 1 None None None 119719948 Common - protoheme IX farnesyltransferase Tpen_1040 164 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 119720325 Nonpathogen - hypothetical protein Tpen_1420 1 None None None 119719951 Common - major facilitator superfamily MFS_1 Tpen_1043 120 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 119719418 Common - beta-lactamase domain protein Tpen_0503 81 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 119720552 Common - PfkB domain protein Tpen_1649 189 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 119719438 Common - putative circadian clock protein, KaiC Tpen_0524 67 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 119720484 Common - glycerophosphoryl diester phosphodiesterase Tpen_1581 184 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 119718956 Nonpathogen - putative adenylyl cyclase CyaB Tpen_0038 32 COG1437 CyaB, Adenylate cyclase, class 2 (thermophilic) Nucleotide transport and metabolism 119719042 Nonpathogen - putative transcriptional regulator, CopG family Tpen_0124 6 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 119719298 Nonpathogen - hypothetical protein Tpen_0381 4 COG3863 COG3863, Uncharacterized distant relative of cell wall-associated hydrolases Function unknown 119719785 Common - protein of unknown function DUF59 Tpen_0876 142 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 119719283 Nonpathogen - putative transcriptional regulator, AsnC family Tpen_0366 8 COG1522 Lrp, Transcriptional regulators Transcription 119720538 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Tpen_1635 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 119719609 Nonpathogen - Protein of unknown function DUF373 Tpen_0699 29 COG2237 COG2237, Predicted membrane protein Function unknown 119720304 Nonpathogen - ABC-2 type transporter Tpen_1399 2 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 119719510 Common - putative molybdenum cofactor biosynthesis protein A Tpen_0597 204 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 119720180 Nonpathogen - hypothetical protein Tpen_1274 3 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 119719089 Common - transglutaminase domain protein Tpen_0171 9 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 119720331 Common - ABC transporter related Tpen_1426 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 119720490 Nonpathogen - hypothetical protein Tpen_1587 1 None None None 119720161 Common - binding-protein-dependent transport systems inner membrane component Tpen_1255 139 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 119720165 Nonpathogen - hypothetical protein Tpen_1259 2 None None None 119719753 Nonpathogen - hypothetical protein Tpen_0844 1 None None None 119720173 Common - ATPase Tpen_1267 11 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 119720394 Nonpathogen - hypothetical protein Tpen_1489 1 None None None 119719138 Nonpathogen - protein of unknown function DUF434 Tpen_0220 13 COG2454 COG2454, Uncharacterized conserved protein Function unknown 119720189 Nonpathogen - hypothetical protein Tpen_1283 1 None None None 119719302 Common - initiation factor 2B related Tpen_0385 132 COG1184 GCD2, Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 119719377 Nonpathogen - protein of unknown function DUF358 Tpen_0460 3 COG1901 COG1901, Uncharacterized conserved protein Function unknown 119720453 Common - binding-protein-dependent transport systems inner membrane component Tpen_1549 159 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 119719586 Nonpathogen - hypothetical protein Tpen_0676 1 None None None 119720103 Common - MscS Mechanosensitive ion channel Tpen_1197 53 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 119718988 Nonpathogen - transcriptional regulator, TrmB Tpen_0070 10 COG1378 COG1378, Predicted transcriptional regulators Transcription 119719180 Nonpathogen - hypothetical protein Tpen_0262 1 None None None 119719573 Nonpathogen - hypothetical protein Tpen_0663 2 None None None 119719187 Common - protein of unknown function UPF0027 Tpen_0269 119 COG1690 RtcB, Uncharacterized conserved protein Function unknown 119720094 Nonpathogen - hypothetical protein Tpen_1188 2 None None None 119720089 Nonpathogen - hypothetical protein Tpen_1183 3 COG2445 COG2445, Uncharacterized conserved protein Function unknown 119719577 Common - DNA topoisomerase VI subunit A Tpen_0667 34 COG1697 COG1697, DNA topoisomerase VI, subunit A DNA replication, recombination, and repair 119719628 Common - geranylgeranyl reductase Tpen_0718 139 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 119720563 Common - Myo-inositol-1-phosphate synthase, GAPDH domain protein Tpen_1660 60 COG1260 INO1, Myo-inositol-1-phosphate synthase Lipid metabolism 119720465 Common - transcriptional regulator, TrmB Tpen_1562 35 COG1378 COG1378, Predicted transcriptional regulators Transcription 119719356 Common - type II secretion system protein E Tpen_0439 223 COG0630 VirB11, Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis Cell motility and secretion / Intracellular trafficking and secretion 119719553 Nonpathogen rps27e 30S ribosomal protein S27e Tpen_0643 32 COG2051 RPS27A, Ribosomal protein S27E Translation, ribosomal structure and biogenesis 119720291 Nonpathogen - Methyltransferase type 12 Tpen_1386 4 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 119720426 Common - Abortive infection protein Tpen_1521 6 None None None 119719167 Nonpathogen - hypothetical protein Tpen_0249 1 None None None 119718922 Common - major facilitator superfamily MFS_1 Tpen_0004 41 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 119718948 Nonpathogen - hypothetical protein Tpen_0030 1 None None None 119720424 Nonpathogen - Dinitrogenase iron-molybdenum cofactor biosynthesis Tpen_1519 8 COG1433 COG1433, Uncharacterized conserved protein Function unknown 119719839 Common - DEAD/H associated domain protein Tpen_0930 219 COG1201 Lhr, Lhr-like helicases General function prediction only 119719512 Common - ABC transporter related Tpen_0599 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 119719995 Common - NADH dehydrogenase (quinone) Tpen_1088 205 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 119720437 Common - Citrate transporter Tpen_1533 71 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 119719675 Common - acetyl-CoA acetyltransferase Tpen_0765 101 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 119719809 Nonpathogen - hypothetical protein Tpen_0900 1 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 119720668 Nonpathogen - glyceraldehyde-3-phosphate dehydrogenase Tpen_1765 35 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 119720118 Common - Methionine synthase Tpen_1212 173 COG5012 COG5012, Predicted cobalamin binding protein General function prediction only 119720112 Common - FeS assembly protein SufB Tpen_1206 182 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 119719894 Nonpathogen - hypothetical protein Tpen_0986 1 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 119719253 Common - CoA-binding domain protein Tpen_0336 142 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 119719047 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Tpen_0129 22 COG1141 Fer, Ferredoxin Energy production and conversion 119720486 Nonpathogen - hypothetical protein Tpen_1583 4 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 119720133 Common rbcL ribulose bisophosphate carboxylase Tpen_1227 68 COG1850 RbcL, Ribulose 1,5-bisphosphate carboxylase, large subunit Carbohydrate transport and metabolism 119719684 Nonpathogen - protein of unknown function DUF75 Tpen_0774 30 COG1938 COG1938, Archaeal enzymes of ATP-grasp superfamily General function prediction only 119720505 Nonpathogen - CRISPR-associated protein Cas4 Tpen_1602 4 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 119719274 Nonpathogen - protein of unknown function DUF75 Tpen_0357 23 COG1938 COG1938, Archaeal enzymes of ATP-grasp superfamily General function prediction only 119720742 Common - pyrroline-5-carboxylate reductase Tpen_1839 213 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 119719070 Nonpathogen - hypothetical protein Tpen_0152 8 COG4998 COG4998, Predicted endonuclease (RecB family) DNA replication, recombination, and repair 119719260 Nonpathogen - hypothetical protein Tpen_0343 1 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 119720474 Nonpathogen - hypothetical protein Tpen_1571 5 None None None 119719434 Nonpathogen - methyltransferase small Tpen_0520 32 COG2263 COG2263, Predicted RNA methylase Translation, ribosomal structure and biogenesis 119720447 Nonpathogen - hypothetical protein Tpen_1543 1 COG3859 COG3859, Predicted membrane protein Function unknown 119719079 Common - Anion-transporting ATPase Tpen_0161 89 COG0003 ArsA, Predicted ATPase involved in chromosome partitioning Cell division and chromosome partitioning 119719264 Nonpathogen - hypothetical protein Tpen_0347 3 None None None 119720081 Common - binding-protein-dependent transport systems inner membrane component Tpen_1175 143 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 119720430 Nonpathogen - hypothetical protein Tpen_1526 5 COG5306 COG5306, Uncharacterized conserved protein Function unknown 119719467 Nonpathogen - hypothetical protein Tpen_0553 3 None None None 119720338 Nonpathogen - DNA polymerase, beta domain protein region Tpen_1433 10 COG1708 COG1708, Predicted nucleotidyltransferases General function prediction only 119719823 Nonpathogen - hypothetical protein Tpen_0914 10 None None None 119720407 Nonpathogen - hypothetical protein Tpen_1502 1 COG2034 COG2034, Predicted membrane protein Function unknown 119719960 Common - acylphosphatase Tpen_1052 95 COG1254 AcyP, Acylphosphatases Energy production and conversion 119720701 Nonpathogen - hypothetical protein Tpen_1798 2 None None None 119720163 Common - extracellular solute-binding protein, family 1 Tpen_1257 60 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 119720353 Nonpathogen - hypothetical protein Tpen_1448 6 COG5550 COG5550, Predicted aspartyl protease Posttranslational modification, protein turnover, chaperones 119720659 Nonpathogen - hypothetical protein Tpen_1756 1 None None None 119720617 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Tpen_1714 49 COG4934 COG4934, Predicted protease Posttranslational modification, protein turnover, chaperones 119719746 Common - Fructose-bisphosphate aldolase Tpen_0837 80 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 119720001 Common - glutamine amidotransferase, class-II Tpen_1094 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 119719458 Nonpathogen - membrane protein-like Tpen_0544 21 COG3356 COG3356, Predicted membrane protein Function unknown 119719231 Common - molybdopterin biosynthesis MoaE Tpen_0314 134 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 119720119 Nonpathogen - hypothetical protein Tpen_1213 6 None None None 119720154 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Tpen_1248 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 119720249 Nonpathogen - ATPase Tpen_1344 5 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 119718929 Nonpathogen - hypothetical protein Tpen_0011 5 None None None 119719160 Common rpl5p 50S ribosomal protein L5P Tpen_0242 248 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 119719485 Common - pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit Tpen_0572 92 COG1144 COG1144, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit Energy production and conversion 119719985 Nonpathogen - NADH dehydrogenase subunit A Tpen_1078 1 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 119719128 Common - glycoside hydrolase, family 57 Tpen_0210 42 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 119720282 Nonpathogen - hypothetical protein Tpen_1377 1 None None None 119719125 Common - Hydroxypyruvate reductase Tpen_0207 86 COG2379 GckA, Putative glycerate kinase Carbohydrate transport and metabolism 119719830 Nonpathogen - hypothetical protein Tpen_0921 1 None None None 119720230 Nonpathogen - hypothetical protein Tpen_1325 2 None None None 119719027 Common - hypothetical protein Tpen_0109 138 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 119720675 Common - THUMP domain protein Tpen_1772 17 COG1818 COG1818, Predicted RNA-binding protein, contains THUMP domain General function prediction only 119719173 Common - aminotransferase, class I and II Tpen_0255 241 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 119720511 Common - hypothetical protein Tpen_1608 24 COG1720 COG1720, Uncharacterized conserved protein Function unknown 119719886 Common - PIN domain protein Tpen_0978 7 None None None 119720652 Nonpathogen - hypothetical protein Tpen_1749 1 None None None 119718996 Nonpathogen - hypothetical protein Tpen_0078 1 None None None 119720606 Common - hypothetical protein Tpen_1703 18 COG4938 COG4938, Uncharacterized conserved protein Function unknown 119718971 Common - amino acid permease-associated region Tpen_0053 102 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 119719937 Nonpathogen - AIR synthase related protein domain protein Tpen_1029 36 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 119720237 Common - ABC-type transport system involved in multi-copper enzyme maturation permease component-like Tpen_1332 20 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 119719147 Nonpathogen rpl4lp 50S ribosomal protein L4P Tpen_0229 34 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 119719346 Common - signal recognition particle-docking protein FtsY Tpen_0429 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 119719222 Common - AAA family ATPase, CDC48 subfamily Tpen_0304 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 119719315 Nonpathogen - nucleic acid binding, OB-fold, tRNA/helicase-type Tpen_0398 1 COG5235 RFA2, Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit DNA replication, recombination, and repair 119720218 Common - ABC-type sulfate/molybdate transport systems ATPase component-like Tpen_1313 133 COG1118 CysA, ABC-type sulfate/molybdate transport systems, ATPase component Inorganic ion transport and metabolism 119719132 Nonpathogen - THUMP domain protein Tpen_0214 10 COG1818 COG1818, Predicted RNA-binding protein, contains THUMP domain General function prediction only 119720708 Common - Creatininase Tpen_1805 88 COG1402 COG1402, Uncharacterized protein, putative amidase General function prediction only 119719359 Nonpathogen - hypothetical protein Tpen_0442 1 None None None 119719728 Common - beta-lactamase domain protein Tpen_0819 80 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 119719904 Common - Cobyrinic acid a,c-diamide synthase Tpen_0996 53 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 119719010 Nonpathogen - hypothetical protein Tpen_0092 8 COG4755 COG4755, Uncharacterized protein conserved in archaea Function unknown 119718932 Common - ABC transporter related Tpen_0014 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 119718974 Nonpathogen - hypothetical protein Tpen_0056 1 None None None 119719667 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Tpen_0757 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 119719322 Nonpathogen - NusG antitermination factor Tpen_0405 34 COG0250 NusG, Transcription antiterminator Transcription 119719767 Nonpathogen - protein of unknown function DUF123 Tpen_0858 40 COG1833 COG1833, Uncharacterized conserved protein Function unknown 119719929 Nonpathogen - hypothetical protein Tpen_1021 2 None None None 119720458 Common - extracellular solute-binding protein, family 1 Tpen_1554 84 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 119719213 Common - Extracellular ligand-binding receptor Tpen_0295 128 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 119720288 Nonpathogen - hypothetical protein Tpen_1383 1 COG3462 COG3462, Predicted membrane protein Function unknown 119719944 Nonpathogen - hypothetical protein Tpen_1036 18 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 119719928 Nonpathogen - hypothetical protein Tpen_1020 1 None None None 119719958 Nonpathogen - hypothetical protein Tpen_1050 1 None None None 119720037 Nonpathogen - HEPN domain protein Tpen_1131 7 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 119719930 Nonpathogen - hypothetical protein Tpen_1022 1 None None None 119719664 Common - threonyl-tRNA synthetase Tpen_0754 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 119719695 Nonpathogen - hypothetical protein Tpen_0785 2 None None None 119719603 Common - thermosome Tpen_0693 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 119719217 Nonpathogen - hypothetical protein Tpen_0299 6 None None None 119719350 Common - hypothetical protein Tpen_0433 34 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 119720225 Common - CRISPR-associated RAMP protein, Cmr4 family Tpen_1320 23 COG1336 COG1336, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 119720060 Common - transcriptional regulator, TrmB Tpen_1154 39 COG1378 COG1378, Predicted transcriptional regulators Transcription 119719811 Common cysS cysteinyl-tRNA synthetase Tpen_0902 246 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 119720634 Nonpathogen - transcriptional regulator, Fis family Tpen_1731 1 None None None 119720076 Nonpathogen - hypothetical protein Tpen_1170 3 None None None 119720570 Common - AIR synthase related protein domain protein Tpen_1667 215 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 119719243 Common - Glutaredoxin-like domain protein Tpen_0326 64 COG3634 AhpF, Alkyl hydroperoxide reductase, large subunit Posttranslational modification, protein turnover, chaperones 119720022 Common - protein of unknown function DUF498 Tpen_1116 12 COG1504 COG1504, Uncharacterized conserved protein Function unknown 119719818 Nonpathogen - peptidase M50 Tpen_0909 23 None None None 119719248 Common - DEAD/DEAH box helicase domain protein Tpen_0331 149 COG1205 COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster General function prediction only 119719721 Nonpathogen - V-type H+-transporting ATPase subunit E Tpen_0812 1 None None None 119720192 Nonpathogen - hypothetical protein Tpen_1286 2 None None None 119719084 Nonpathogen - hypothetical protein Tpen_0166 1 None None None 119720467 Common - anion transporter Tpen_1564 105 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 119719203 Common - DNA-directed RNA polymerase subunit alpha Tpen_0285 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 119719019 Common - 5-formyltetrahydrofolate cyclo-ligase Tpen_0101 22 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 119719154 Common rps5p 30S ribosomal protein S5P Tpen_0236 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 119719597 Nonpathogen - hypothetical protein Tpen_0687 1 COG1145 NapF, Ferredoxin Energy production and conversion 119720636 Nonpathogen - hypothetical protein Tpen_1733 1 None None None 119720370 Common - class II aldolase/adducin family protein Tpen_1465 176 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 119718977 Common - amidohydrolase Tpen_0059 163 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 119719390 Nonpathogen - Ribosomal protein L31e Tpen_0473 29 COG2097 RPL31A, Ribosomal protein L31E Translation, ribosomal structure and biogenesis 119720400 Nonpathogen - transcriptional regulator, AbrB family Tpen_1495 3 None None None 119719697 Nonpathogen - hypothetical protein Tpen_0787 1 None None None 119718967 Nonpathogen - hypothetical protein Tpen_0049 1 None None None 119720492 Common - binding-protein-dependent transport systems inner membrane component Tpen_1589 154 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 119720576 Nonpathogen - hypothetical protein Tpen_1673 3 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 119719773 Nonpathogen - peptidase M50 Tpen_0864 48 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 119720590 Common - HEPN domain protein Tpen_1687 20 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 119720721 Common - sugar fermentation stimulation protein A Tpen_1818 105 COG1489 SfsA, DNA-binding protein, stimulates sugar fermentation General function prediction only 119719305 Nonpathogen - RNase P/RNase MRP subunit p30-like Tpen_0388 1 COG1603 RPP1, RNase P/RNase MRP subunit p30 Translation, ribosomal structure and biogenesis 119720156 Common - Nucleotidyl transferase Tpen_1250 27 COG1213 COG1213, Predicted sugar nucleotidyltransferases Cell envelope biogenesis, outer membrane 119720546 Nonpathogen - hypothetical protein Tpen_1643 1 None None None 119720732 Common - Nucleotidyl transferase Tpen_1829 233 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 119719441 Common - SMC domain protein Tpen_0527 90 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 119720410 Common - Cytochrome bd-type quinol oxidase subunit 1-like Tpen_1505 24 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 119719416 Common - DNA primase Tpen_0501 36 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 119720412 Nonpathogen - hypothetical protein Tpen_1507 4 None None None 119719502 Common - hydrogenase maturation protease Tpen_0589 13 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 119719142 Common - ribosomal protein L11 Tpen_0224 240 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 119720075 Common - NAD-dependent epimerase/dehydratase Tpen_1169 237 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 119720380 Common - ABC transporter related Tpen_1475 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 119720244 Nonpathogen - hypothetical protein Tpen_1339 2 None None None 119719655 Nonpathogen - protein of unknown function DUF814 Tpen_0745 34 COG1293 COG1293, Predicted RNA-binding protein homologous to eukaryotic snRNP Transcription 119719702 Common - Starch synthase Tpen_0792 185 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 119720146 Common - uridine phosphorylase Tpen_1240 98 COG2820 Udp, Uridine phosphorylase Nucleotide transport and metabolism 119720558 Nonpathogen - hypothetical protein Tpen_1655 29 COG1633 COG1633, Uncharacterized conserved protein Function unknown 119720507 Common - ParB domain protein nuclease Tpen_1604 12 COG1475 Spo0J, Predicted transcriptional regulators Transcription 119720527 Common - 2-dehydro-3-deoxyglucarate aldolase Tpen_1624 74 COG3836 HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase Carbohydrate transport and metabolism 119719582 Nonpathogen - hypothetical protein Tpen_0672 1 None None None 119720396 Nonpathogen - BioY protein Tpen_1491 1 COG1268 BioY, Uncharacterized conserved protein General function prediction only 119719632 Nonpathogen - hypothetical protein Tpen_0722 1 None None None 119720597 Nonpathogen - PilT protein domain protein Tpen_1694 4 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 119720589 Nonpathogen - DNA polymerase, beta domain protein region Tpen_1686 7 COG1708 COG1708, Predicted nucleotidyltransferases General function prediction only 119720055 Common - ABC transporter related Tpen_1149 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 119720694 Common - methylpurine-DNA glycosylase (MPG) Tpen_1791 57 COG2094 Mpg, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 119720317 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Tpen_1412 153 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 119719709 Nonpathogen - hypothetical protein Tpen_0799 1 None None None 119719255 Nonpathogen - H+-transporting two-sector ATPase, C subunit Tpen_0338 1 None None None 119719149 Nonpathogen - Protein of unknown function DUF171 Tpen_0231 21 COG2106 COG2106, Uncharacterized conserved protein Function unknown 119720362 Common - Rubredoxin-type Fe(Cys)4 protein Tpen_1457 123 COG1773 COG1773, Rubredoxin Energy production and conversion 119719340 Nonpathogen - hypothetical protein Tpen_0423 1 None None None 119720604 Nonpathogen - hypothetical protein Tpen_1701 2 COG5550 COG5550, Predicted aspartyl protease Posttranslational modification, protein turnover, chaperones 119719333 Common - DNA-cytosine methyltransferase Tpen_0416 109 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 119720346 Nonpathogen - hypothetical protein Tpen_1441 1 None None None 119719891 Nonpathogen - hypothetical protein Tpen_0983 6 COG1483 COG1483, Predicted ATPase (AAA+ superfamily) General function prediction only 119719612 Nonpathogen - hypothetical protein Tpen_0702 11 COG4046 COG4046, Uncharacterized protein conserved in archaea Function unknown 119720383 Nonpathogen - transcriptional regulator, AbrB family Tpen_1478 1 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 119719304 Nonpathogen - hypothetical protein Tpen_0387 1 None None None 119719082 Common - ATPase associated with various cellular activities, AAA_3 Tpen_0164 176 COG0714 COG0714, MoxR-like ATPases General function prediction only 119719626 Nonpathogen - hypothetical protein Tpen_0716 1 None None None 119720440 Common - protein of unknown function DUF554 Tpen_1536 47 COG1811 COG1811, Uncharacterized membrane protein, possible Na+ channel or pump General function prediction only 119718939 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Tpen_0021 102 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 119719280 Nonpathogen - hypothetical protein Tpen_0363 3 None None None 119719379 Nonpathogen - 50S ribosomal protein L14e Tpen_0462 18 COG2163 RPL14A, Ribosomal protein L14E/L6E/L27E Translation, ribosomal structure and biogenesis 119720167 Nonpathogen - Alba, DNA/RNA-binding protein Tpen_1261 1 COG1581 Ssh10b, Archaeal DNA-binding protein Transcription 119719166 Common - peptidase M24 Tpen_0248 248 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 119720531 Common - glycoside hydrolase, family 38 Tpen_1628 51 COG0383 AMS1, Alpha-mannosidase Carbohydrate transport and metabolism 119719751 Nonpathogen - hypothetical protein Tpen_0842 1 None None None 119719851 Nonpathogen - Protein of unknown function DUF650, N-terminal domain Tpen_0943 32 COG1602 COG1602, Uncharacterized conserved protein Function unknown 119720626 Common - glycosyl transferase, group 1 Tpen_1723 230 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 119719833 Nonpathogen - thiamineS protein Tpen_0924 1 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 119719545 Nonpathogen - hypothetical protein Tpen_0634 1 COG4023 SBH1, Preprotein translocase subunit Sec61beta Intracellular trafficking and secretion 119720044 Nonpathogen - putative ABC-2 type transport system permease protein Tpen_1138 2 None None None 119719428 Nonpathogen - phosphoesterase, RecJ domain protein Tpen_0514 31 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 119720568 Nonpathogen - hypothetical protein Tpen_1665 3 None None None 119720125 Nonpathogen - hypothetical protein Tpen_1219 1 None None None 119719430 Common - transcriptional regulator, Fis family Tpen_0516 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 119719037 Common - Carbamoyl-phosphate synthase L chain, ATP-binding Tpen_0119 235 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 119719495 Nonpathogen - exosome complex RNA-binding protein Rrp4 Tpen_0582 24 COG1097 RRP4, RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain) Translation, ribosomal structure and biogenesis 119720092 Nonpathogen - hypothetical protein Tpen_1186 1 None None None 119720336 Common - PHP C-terminal domain protein Tpen_1431 34 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 119720648 Common - glycosyl transferase, family 2 Tpen_1745 73 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 119719523 Common - threonine dehydratase Tpen_0611 207 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 119719182 Nonpathogen - hypothetical protein Tpen_0264 1 None None None 119720550 Common - carbohydrate kinase, YjeF related protein Tpen_1647 222 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 119719953 Nonpathogen - hypothetical protein Tpen_1045 1 None None None 119720263 Nonpathogen - transcriptional regulator, TrmB Tpen_1358 5 COG3355 COG3355, Predicted transcriptional regulator Transcription 119719718 Nonpathogen - protein of unknown function Met10 Tpen_0809 35 COG2520 COG2520, Predicted methyltransferase General function prediction only 119720302 Nonpathogen - DNA polymerase, beta domain protein region Tpen_1397 4 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 119719578 Nonpathogen - putative transcriptional regulator, AsnC family Tpen_0668 14 COG1522 Lrp, Transcriptional regulators Transcription 119719878 Nonpathogen - hypothetical protein Tpen_0970 1 None None None 119719431 Common - succinyl-CoA synthetase, alpha subunit Tpen_0517 220 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 119720255 Common - amidohydrolase Tpen_1350 136 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 119720250 Nonpathogen - hypothetical protein Tpen_1345 1 None None None 119719647 Common - S-adenosylmethionine synthetase Tpen_0737 43 COG1812 MetK, Archaeal S-adenosylmethionine synthetase Amino acid transport and metabolism 119720731 Nonpathogen - hypothetical protein Tpen_1828 2 None None None 119719971 Common - GMP reductase Tpen_1064 235 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 119720684 Nonpathogen - Protein of unknown function DUF650, N-terminal domain Tpen_1781 32 COG1602 COG1602, Uncharacterized conserved protein Function unknown 119719096 Common - molybdopterin-guanine dinucleotide biosynthesis protein Tpen_0178 53 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 119720595 Nonpathogen - DNA polymerase, beta domain protein region Tpen_1692 8 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 119719558 Common rps10p 30S ribosomal protein S10P Tpen_0648 238 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 119720206 Nonpathogen - HEPN domain protein Tpen_1300 10 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 119719465 Nonpathogen - hypothetical protein Tpen_0551 1 None None None 119719196 Common - ribosomal protein L13 Tpen_0278 159 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 119720190 Common - Ankyrin Tpen_1284 127 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 119720418 Common - amino acid permease-associated region Tpen_1513 116 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 119720270 Nonpathogen - hypothetical protein Tpen_1365 2 None None None 119719726 Common - prolyl-tRNA synthetase Tpen_0817 240 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 119720227 Nonpathogen - CRISPR-associated protein Cas2 Tpen_1322 2 COG1343 COG1343, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 119720062 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Tpen_1156 36 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 119719392 Nonpathogen - Radical SAM domain protein Tpen_0475 27 COG1031 COG1031, Uncharacterized Fe-S oxidoreductase Energy production and conversion 119718995 Nonpathogen - hypothetical protein Tpen_0077 1 None None None 119719599 Nonpathogen - diphthine synthase Tpen_0689 34 COG1798 DPH5, Diphthamide biosynthesis methyltransferase Translation, ribosomal structure and biogenesis 119719913 Common - protein of unknown function DUF265 Tpen_1005 24 COG1618 COG1618, Predicted nucleotide kinase Nucleotide transport and metabolism 119718961 Common - peptidase U62, modulator of DNA gyrase Tpen_0043 169 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 119719451 Nonpathogen - hypothetical protein Tpen_0537 1 None None None 119720635 Nonpathogen - hypothetical protein Tpen_1732 7 COG5625 COG5625, Predicted transcription regulator containing HTH domain Transcription 119719821 Common - binding-protein-dependent transport systems inner membrane component Tpen_0912 139 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 119719981 Nonpathogen - hypothetical protein Tpen_1074 1 None None None 119719249 Nonpathogen - hypothetical protein Tpen_0332 6 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 119719214 Nonpathogen rpl40e 50S ribosomal protein L40e Tpen_0296 14 COG1552 RPL40A, Ribosomal protein L40E Translation, ribosomal structure and biogenesis 119719406 Nonpathogen rpl37ae 50S ribosomal protein L37Ae Tpen_0491 34 COG1997 RPL43A, Ribosomal protein L37AE/L43A Translation, ribosomal structure and biogenesis 119720232 Nonpathogen - hypothetical protein Tpen_1327 1 None None None 119718982 Common - hypothetical protein Tpen_0064 14 COG4720 COG4720, Predicted membrane protein Function unknown 119718930 Common - hypothetical protein Tpen_0012 6 COG4754 COG4754, Uncharacterized conserved protein Function unknown 119720028 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Tpen_1122 168 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 119719238 Nonpathogen - 50S ribosomal protein L35Ae Tpen_0321 9 COG2451 COG2451, Ribosomal protein L35AE/L33A Translation, ribosomal structure and biogenesis 119719060 Common - stationary-phase survival protein SurE Tpen_0142 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 119720204 Common - hypothetical protein Tpen_1298 2 None None None 119720679 Common - protein of unknown function DUF214 Tpen_1776 140 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 119719320 Nonpathogen - hypothetical protein Tpen_0403 1 None None None 119720641 Nonpathogen - polysaccharide biosynthesis protein Tpen_1738 1 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 119719381 Common - Radical SAM domain protein Tpen_0464 34 COG2108 COG2108, Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme General function prediction only 119719102 Common - NADH dehydrogenase (quinone) Tpen_0184 207 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 119719440 Nonpathogen - hypothetical protein Tpen_0526 1 COG2136 IMP4, Predicted exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component, contains IMP4 domain Translation, ribosomal structure and biogenesis / RNA processing and modification 119720323 Nonpathogen - hypothetical protein Tpen_1418 1 None None None 119719363 Common - beta-lactamase domain protein Tpen_0446 191 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 119720433 Nonpathogen - major facilitator superfamily MFS_1 Tpen_1529 4 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 119719850 Nonpathogen - putative signal transduction protein with CBS domains Tpen_0942 48 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 119719892 Nonpathogen - hypothetical protein Tpen_0984 1 None None None 119720460 Nonpathogen - HEPN domain protein Tpen_1556 9 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 119720179 Common - ABC transporter related Tpen_1273 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 119719388 Nonpathogen - DNA-binding TFAR19-related protein Tpen_0471 31 COG2118 COG2118, DNA-binding protein General function prediction only 119719321 Common - UbiD family decarboxylases Tpen_0404 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 119719927 Nonpathogen - hypothetical protein Tpen_1019 1 None None None 119719642 Nonpathogen - hypothetical protein Tpen_0732 1 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 119719189 Common - protein of unknown function DUF101 Tpen_0271 36 COG1371 COG1371, Uncharacterized conserved protein Function unknown 119720532 Nonpathogen - hypothetical protein Tpen_1629 1 None None None 119719383 Common - regulatory protein, ArsR Tpen_0466 85 COG4189 COG4189, Predicted transcriptional regulator Transcription 119720456 Common - protein of unknown function DUF187 Tpen_1552 12 COG1649 COG1649, Uncharacterized protein conserved in bacteria Function unknown 119719812 Nonpathogen - hypothetical protein Tpen_0903 1 None None None 119720488 Common - GCN5-related N-acetyltransferase Tpen_1585 50 COG0456 RimI, Acetyltransferases General function prediction only 119720040 Common - protein of unknown function DUF340, membrane Tpen_1134 48 COG2431 COG2431, Predicted membrane protein Function unknown 119719165 Nonpathogen - protein of unknown function DUF99 Tpen_0247 29 COG1628 COG1628, Uncharacterized conserved protein Function unknown 119719069 Nonpathogen - hypothetical protein Tpen_0151 1 None None None 119720170 Nonpathogen - hypothetical protein Tpen_1264 2 None None None 119720398 Common - beta-lactamase domain protein Tpen_1493 118 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 119719568 Common - Radical SAM domain protein Tpen_0658 108 COG2100 COG2100, Predicted Fe-S oxidoreductase General function prediction only 119719314 Common - hypothetical protein Tpen_0397 23 COG0433 COG0433, Predicted ATPase General function prediction only 119720217 Nonpathogen - hypothetical protein Tpen_1312 7 COG1992 COG1992, Uncharacterized conserved protein Function unknown 119719834 Nonpathogen - protein of unknown function UPF0044 Tpen_0925 8 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 119720131 Common - peptidase M1, membrane alanine aminopeptidase Tpen_1225 168 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 119720348 Nonpathogen - hypothetical protein Tpen_1443 2 None None None 119720220 Nonpathogen - hypothetical protein Tpen_1315 1 None None None 119719470 Nonpathogen - eRF1 domain 3 protein Tpen_0556 34 COG1537 PelA, Predicted RNA-binding proteins General function prediction only 119719991 Nonpathogen - conserved hypothetical NADH-plastoquinone oxidoreductase subunit 6 Tpen_1084 5 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 119719127 Nonpathogen - protein of unknown function DUF95, transmembrane Tpen_0209 20 COG1300 SpoIIM, Uncharacterized membrane protein Function unknown 119720007 Common - PTS system mannose/fructose/sorbose family IID component Tpen_1100 40 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 119720699 Common - Periplasmic molybdate-binding protein/domain-like Tpen_1796 60 COG1910 COG1910, Periplasmic molybdate-binding protein/domain Inorganic ion transport and metabolism 119720013 Nonpathogen - glutamine amidotransferase class-I Tpen_1106 4 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 119720268 Nonpathogen - hypothetical protein Tpen_1363 2 COG1567 COG1567, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 119719537 Nonpathogen - transcription termination factor Tfs Tpen_0625 32 COG1594 RPB9, DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS Transcription 119720337 Nonpathogen - hypothetical protein Tpen_1432 2 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 119720251 Nonpathogen - putative transcriptional regulator, CopG family Tpen_1346 2 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 119719790 Common - Radical SAM domain protein Tpen_0881 51 COG1313 PflX, Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins General function prediction only 119719178 Nonpathogen - hypothetical protein Tpen_0260 1 None None None 119719155 Nonpathogen rpl18p 50S ribosomal protein L18P Tpen_0237 34 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 119719122 Common - amine oxidase Tpen_0204 59 COG1232 HemY, Protoporphyrinogen oxidase Coenzyme metabolism 119720052 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Tpen_1146 30 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 119720677 Nonpathogen - hypothetical protein Tpen_1774 1 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 119719997 Common - hypothetical protein Tpen_1090 18 COG4821 COG4821, Uncharacterized protein containing SIS (Sugar ISomerase) phosphosugar binding domain General function prediction only 119720113 Common - SufBD protein Tpen_1207 60 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 119720341 Nonpathogen - hypothetical protein Tpen_1436 7 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 119719016 Nonpathogen - protein of unknown function DUF120 Tpen_0098 32 COG1339 COG1339, Transcriptional regulator of a riboflavin/FAD biosynthetic operon Transcription / Coenzyme metabolism 119720477 Nonpathogen - SMC domain protein Tpen_1574 11 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 119719757 Common - asparaginyl-tRNA synthetase Tpen_0848 249 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 119719464 Nonpathogen - hypothetical protein Tpen_0550 1 None None None 119719719 Common - Phosphomannomutase Tpen_0810 240 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 119719861 Nonpathogen - transcriptional regulator, MarR family Tpen_0953 5 COG1846 MarR, Transcriptional regulators Transcription 119719514 Common - inner-membrane translocator Tpen_0601 161 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 119719114 Common - protein of unknown function DUF100 Tpen_0196 38 COG1980 COG1980, Archaeal fructose 1,6-bisphosphatase Carbohydrate transport and metabolism 119719039 Common - periplasmic solute binding protein Tpen_0121 36 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 119719281 Nonpathogen - transcriptional regulator, Fis family Tpen_0364 12 COG1761 RPB11, DNA-directed RNA polymerase, subunit L Transcription 119719024 Common - phage integrase family protein Tpen_0106 231 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 119719500 Common - tryptophanyl-tRNA synthetase Tpen_0587 102 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 119720544 Common - major facilitator superfamily MFS_1 Tpen_1641 168 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 119718924 Common - ABC transporter related Tpen_0006 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 119720650 Nonpathogen - hypothetical protein Tpen_1747 4 None None None 119720315 Nonpathogen - formate dehydrogenase, cytochrome b556 subunit (formate dehydrogenase gamma subunit) Tpen_1410 3 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 119719682 Nonpathogen - hypothetical protein Tpen_0772 1 None None None 119720122 Nonpathogen - hypothetical protein Tpen_1216 1 None None None 119719479 Nonpathogen - hypothetical protein Tpen_0565 1 None None None 119719680 Nonpathogen - hypothetical protein Tpen_0770 1 None None None 119719775 Nonpathogen - holliday junction resolvase Tpen_0866 1 COG1591 COG1591, Holliday junction resolvase - archaeal type DNA replication, recombination, and repair 119719288 Nonpathogen - protein of unknown function, ATP binding Tpen_0371 15 COG1100 COG1100, GTPase SAR1 and related small G proteins General function prediction only 119719652 Nonpathogen - hypothetical protein Tpen_0742 2 None None None 119719262 Nonpathogen - hypothetical protein Tpen_0345 1 None None None 119719334 Nonpathogen - hypothetical protein Tpen_0417 1 None None None 119720428 Nonpathogen - hypothetical protein Tpen_1524 2 None None None 119720140 Nonpathogen - hypothetical protein Tpen_1234 1 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 119720105 Common - geranylgeranyl reductase Tpen_1199 84 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 119719484 Common - pyruvate/ketoisovalerate oxidoreductase, gamma subunit Tpen_0571 62 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 119719845 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Tpen_0937 7 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 119719233 Common - succinyl-diaminopimelate desuccinylase Tpen_0316 179 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 119719119 Common - phosphodiesterase, MJ0936 family Tpen_0201 39 COG0622 COG0622, Predicted phosphoesterase General function prediction only 119719112 Common - hypothetical protein Tpen_0194 116 COG2110 COG2110, Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 General function prediction only 119720355 Nonpathogen - phosphatidate cytidylyltransferase Tpen_1450 1 COG0170 SEC59, Dolichol kinase Lipid metabolism 119720445 Common - ABC transporter related Tpen_1541 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 119719532 Common - phosphoribosyltransferase Tpen_0620 75 COG2236 COG2236, Predicted phosphoribosyltransferases General function prediction only 119719710 Nonpathogen - hypothetical protein Tpen_0800 1 None None None 119719075 Nonpathogen - hypothetical protein Tpen_0157 1 COG1984 DUR1, Allophanate hydrolase subunit 2 Amino acid transport and metabolism 119719032 Common - FAD dependent oxidoreductase Tpen_0114 101 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 119719994 Common - proton-translocating NADH-quinone oxidoreductase, chain L Tpen_1087 206 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 119720308 Common - protein of unknown function DUF214 Tpen_1403 140 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 119720529 Common - hypothetical protein Tpen_1626 30 COG1416 COG1416, Uncharacterized conserved protein Function unknown 119718987 Nonpathogen - conserved hypothetical phosphomethylpyrimidine kinase Tpen_0069 22 COG1992 COG1992, Uncharacterized conserved protein Function unknown 119719294 Nonpathogen - fibrillarin Tpen_0377 34 COG1889 NOP1, Fibrillarin-like rRNA methylase Translation, ribosomal structure and biogenesis 119719143 Common rps19p 30S ribosomal protein S19P Tpen_0225 246 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 119720712 Nonpathogen - hypothetical protein Tpen_1809 6 None None None 119720184 Nonpathogen - hypothetical protein Tpen_1278 1 None None None 119719976 Common - phosphate uptake regulator, PhoU Tpen_1069 30 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 119720321 Nonpathogen - hypothetical protein Tpen_1416 1 None None None 119719972 Nonpathogen - phosphate uptake regulator, PhoU Tpen_1065 26 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 119719797 Nonpathogen - phosphoesterase, DHHA1 Tpen_0888 2 COG2404 COG2404, Predicted phosphohydrolase (DHH superfamily) General function prediction only 119720188 Nonpathogen - hypothetical protein Tpen_1282 1 None None None 119719614 Nonpathogen - hypothetical protein Tpen_0704 1 None None None 119719935 Common - phospholipase D/Transphosphatidylase Tpen_1027 53 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 119719828 Nonpathogen - hypothetical protein Tpen_0919 1 None None None 119719492 Common - putative transcriptional regulator, AsnC family Tpen_0579 177 COG1522 Lrp, Transcriptional regulators Transcription 119720469 Common - beta-lactamase domain protein Tpen_1566 121 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 119720239 Common - membrane protein-like Tpen_1334 15 COG1470 COG1470, Predicted membrane protein Function unknown 119720593 Nonpathogen - HEPN domain protein Tpen_1690 13 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 119720692 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Tpen_1789 88 COG0348 NapH, Polyferredoxin Energy production and conversion 119719761 Common - major facilitator superfamily MFS_1 Tpen_0852 51 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 119720169 Nonpathogen - putative CRISPR-associated protein, APE2256 family Tpen_1263 13 COG4006 COG4006, Uncharacterized protein conserved in archaea Function unknown 119720534 Common - Formate dehydrogenase Tpen_1631 178 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 119719557 Common - elongation factor 1-alpha Tpen_0647 249 COG5256 TEF1, Translation elongation factor EF-1alpha (GTPase) Translation, ribosomal structure and biogenesis 119720737 Nonpathogen - hypothetical protein Tpen_1834 1 None None None 119719183 Nonpathogen - cell division control protein 6 Tpen_0265 31 COG1474 CDC6, Cdc6-related protein, AAA superfamily ATPase DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones 119720253 Nonpathogen - hypothetical protein Tpen_1348 1 None None None 119720520 Common - binding-protein-dependent transport systems inner membrane component Tpen_1617 176 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 119719624 Common - ABC transporter related Tpen_0714 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 119719581 Nonpathogen - hypothetical protein Tpen_0671 1 None None None 119718940 Nonpathogen - hypothetical protein Tpen_0022 7 COG1693 COG1693, Uncharacterized protein conserved in archaea Function unknown 119719768 Common - Quinolinate phosphoribosyl transferase Tpen_0859 120 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 119719677 Nonpathogen - hypothetical protein Tpen_0767 15 COG3357 COG3357, Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon Transcription 119720038 Nonpathogen - DNA polymerase, beta domain protein region Tpen_1132 3 None None None 119719692 Common - pyruvate ferredoxin/flavodoxin oxidoreductase Tpen_0782 92 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 119719035 Common - Polyprenyl synthetase Tpen_0117 242 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 119719157 Nonpathogen - Ribosomal protein L32e Tpen_0239 34 COG1717 RPL32, Ribosomal protein L32E Translation, ribosomal structure and biogenesis 119719229 Common - molybdenum cofactor synthesis domain Tpen_0312 188 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 119719493 Common - exosome complex RNA-binding protein Rrp42 Tpen_0580 41 COG2123 COG2123, RNase PH-related exoribonuclease Translation, ribosomal structure and biogenesis 119718949 Common - NAD-dependent epimerase/dehydratase Tpen_0031 235 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 119720555 Common - nitroreductase Tpen_1652 125 COG0778 NfnB, Nitroreductase Energy production and conversion 119719414 Common - translation initiation factor IF-2 Tpen_0499 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 119719372 Nonpathogen - hypothetical protein Tpen_0455 2 COG2412 COG2412, Uncharacterized conserved protein Function unknown 119720082 Common - binding-protein-dependent transport systems inner membrane component Tpen_1176 140 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 119719412 Nonpathogen - MCM family protein Tpen_0497 34 COG1241 MCM2, Predicted ATPase involved in replication control, Cdc46/Mcm family DNA replication, recombination, and repair 119719509 Common - ATPase involved in chromosome partitioning, ParA/MinD family, Mrp-like Tpen_0596 228 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 119719368 Nonpathogen - hypothetical protein Tpen_0451 1 None None None 119719890 Common - protein of unknown function DUF1156 Tpen_0982 39 COG1743 COG1743, Adenine-specific DNA methylase containing a Zn-ribbon DNA replication, recombination, and repair 119720702 Nonpathogen - hypothetical protein Tpen_1799 1 None None None 119719843 Nonpathogen - hypothetical protein Tpen_0934 3 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 119719737 Nonpathogen - hypothetical protein Tpen_0828 7 None None None 119720265 Nonpathogen - hypothetical protein Tpen_1360 2 COG5551 COG5551, Uncharacterized conserved protein Function unknown 119720517 Common - hypothetical protein Tpen_1614 11 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 119720584 Common - glycoside hydrolase, family 12 Tpen_1681 6 None None None 119720431 Nonpathogen - hypothetical protein Tpen_1527 2 None None None 119720497 Common - daunorubicin resistance ABC transporter ATPase subunit Tpen_1594 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 119719744 Nonpathogen - hypothetical protein Tpen_0835 1 None None None 119719172 Common - Roadblock/LC7 family protein Tpen_0254 10 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 119719876 Nonpathogen - hypothetical protein Tpen_0968 2 None None None 119720385 Common - K+-transporting ATPase, B subunit Tpen_1480 232 COG2216 KdpB, High-affinity K+ transport system, ATPase chain B Inorganic ion transport and metabolism 119720242 Nonpathogen - hypothetical protein Tpen_1337 1 None None None 119720298 Nonpathogen - hypothetical protein Tpen_1393 1 None None None 119719814 Common - polar amino acid ABC transporter, inner membrane subunit Tpen_0905 172 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 119719090 Common - carbamate kinase Tpen_0172 69 COG0549 ArcC, Carbamate kinase Amino acid transport and metabolism 119719054 Common - Inorganic diphosphatase Tpen_0136 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 119720281 Common - competence damage-inducible protein A Tpen_1376 166 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 119720047 Common - flavin reductase domain protein, FMN-binding Tpen_1141 58 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 119719638 Nonpathogen - helicase c2 Tpen_0728 1 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 119719704 Common - hypothetical protein Tpen_0794 76 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 119718975 Nonpathogen - hypothetical protein Tpen_0057 1 None None None 119719062 Nonpathogen - hypothetical protein Tpen_0144 1 None None None 119718937 Nonpathogen - hypothetical protein Tpen_0019 1 None None None 119720160 Common - Radical SAM domain protein Tpen_1254 78 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 119718997 Nonpathogen - hypothetical protein Tpen_0079 1 None None None 119719003 Common - D-fructose-6-phosphate amidotransferase Tpen_0085 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 119719307 Nonpathogen - 50S ribosomal protein L15e Tpen_0390 34 COG1632 RPL15A, Ribosomal protein L15E Translation, ribosomal structure and biogenesis 119720279 Common - hypothetical protein Tpen_1374 3 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 119720624 Common - glycosyl transferase, group 1 Tpen_1721 59 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 119719201 Nonpathogen - ribosomal protein L7Ae/L30e/S12e/Gadd45 Tpen_0283 30 COG1911 RPL30, Ribosomal protein L30E Translation, ribosomal structure and biogenesis 119719802 Common - acetyl-CoA synthetase Tpen_0893 218 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 119719433 Nonpathogen - peptide chain release factor 1 Tpen_0519 35 COG1503 eRF1, Peptide chain release factor 1 (eRF1) Translation, ribosomal structure and biogenesis 119720734 Common - major facilitator superfamily MFS_1 Tpen_1831 40 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 119719783 Nonpathogen - hypothetical protein Tpen_0874 1 None None None 119720079 Nonpathogen - ABC-2 type transporter Tpen_1173 6 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 119720438 Common - protein of unknown function DUF1393 Tpen_1534 6 COG4720 COG4720, Predicted membrane protein Function unknown 119719644 Nonpathogen - ribosomal protein L13 Tpen_0734 8 COG4352 RPL13, Ribosomal protein L13E Translation, ribosomal structure and biogenesis 119720574 Nonpathogen - hypothetical protein Tpen_1671 3 None None None 119719347 Nonpathogen - prefoldin, alpha subunit Tpen_0430 29 COG1730 GIM5, Predicted prefoldin, molecular chaperone implicated in de novo protein folding Posttranslational modification, protein turnover, chaperones 119720481 Common - inner-membrane translocator Tpen_1578 153 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 119720601 Nonpathogen - HEPN domain protein Tpen_1698 19 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 119719615 Nonpathogen - hypothetical protein Tpen_0705 1 None None None 119720149 Nonpathogen - hypothetical protein Tpen_1243 1 None None None 119719525 Common - elongation factor EF-2 Tpen_0613 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 119720591 Nonpathogen - HEPN domain protein Tpen_1688 6 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 119719028 Common - DegT/DnrJ/EryC1/StrS aminotransferase Tpen_0110 194 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 119719327 Nonpathogen - phosphopantetheine adenylyltransferase Tpen_0410 21 COG1019 COG1019, Predicted nucleotidyltransferase General function prediction only 119719104 Common - NADH-ubiquinone oxidoreductase, chain 4L Tpen_0186 34 COG4237 HyfE, Hydrogenase 4 membrane component (E) Energy production and conversion 119719014 Nonpathogen - hypothetical protein Tpen_0096 1 None None None 119719786 Common - ERCC4 domain protein Tpen_0877 35 COG1948 MUS81, ERCC4-type nuclease DNA replication, recombination, and repair 119720435 Common - SufBD protein Tpen_1531 173 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 119720086 Common - Radical SAM domain protein Tpen_1180 157 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 119719588 Nonpathogen - TGS domain protein Tpen_0678 38 COG1163 DRG, Predicted GTPase General function prediction only 119719566 Nonpathogen - Prefoldin beta- domain protein Tpen_0656 30 COG1382 GimC, Prefoldin, chaperonin cofactor Posttranslational modification, protein turnover, chaperones 119720043 Nonpathogen - ABC-2 type transporter Tpen_1137 19 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 119720051 Nonpathogen - hypothetical protein Tpen_1145 1 None None None 119719541 Nonpathogen - zinc finger, SWIM domain protein Tpen_0629 2 COG5431 COG5431, Uncharacterized metal-binding protein Function unknown 119719663 Nonpathogen - hypothetical protein Tpen_0753 8 None None None 119719370 Common - Mn2+-dependent serine/threonine protein kinase Tpen_0453 45 COG3642 COG3642, Mn2+-dependent serine/threonine protein kinase Signal transduction mechanisms 119719911 Common - ATPases involved in chromosome partitioning-like Tpen_1003 11 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 119720213 Nonpathogen - paREP6 Tpen_1307 3 None None None 119720335 Common - Redoxin domain protein Tpen_1430 200 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 119719385 Nonpathogen - hypothetical protein Tpen_0468 1 None None None 119719925 Common radA DNA repair and recombination protein RadA Tpen_1017 123 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 119719917 Common - histidine triad (HIT) protein Tpen_1009 234 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 119719311 Nonpathogen - hypothetical protein Tpen_0394 6 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 119719318 Common - putative signal-transduction protein with CBS domains Tpen_0401 154 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 119720272 Nonpathogen - hypothetical protein Tpen_1367 1 None None None 119720215 Nonpathogen - hypothetical protein Tpen_1310 1 COG5551 COG5551, Uncharacterized conserved protein Function unknown 119719424 Nonpathogen rpoP DNA-directed RNA polymerase subunit P Tpen_0510 7 COG1996 RPC10, DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger) Transcription 119720704 Common - protein of unknown function DUF1641 Tpen_1801 12 COG2427 COG2427, Uncharacterized conserved protein Function unknown 119720725 Common - UBA/THIF-type NAD/FAD binding protein Tpen_1822 225 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 119719855 Nonpathogen - hypothetical protein Tpen_0947 5 COG5306 COG5306, Uncharacterized conserved protein Function unknown 119719210 Nonpathogen - putative phage repressor Tpen_0292 4 COG2932 COG2932, Predicted transcriptional regulator Transcription 119719227 Nonpathogen - PUA domain containing protein Tpen_0310 34 COG2016 COG2016, Predicted RNA-binding protein (contains PUA domain) Translation, ribosomal structure and biogenesis 119720198 Nonpathogen - hypothetical protein Tpen_1292 2 None None None 119719600 Nonpathogen tfb transcription initiation factor IIB Tpen_0690 34 COG1405 SUA7, Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB Transcription 119719247 Common - Pyruvate kinase Tpen_0330 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 119719755 Nonpathogen - membrane protein-like Tpen_0846 6 COG4920 COG4920, Predicted membrane protein Function unknown 119719724 Nonpathogen - protein of unknown function DUF343 Tpen_0815 10 COG2835 COG2835, Uncharacterized conserved protein Function unknown 119719400 Common rpl14p 50S ribosomal protein L14P Tpen_0483 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 119719118 Common - Inositol-phosphate phosphatase Tpen_0200 201 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 119720258 Nonpathogen - hypothetical protein Tpen_1353 1 COG2254 COG2254, Predicted HD superfamily hydrolase, possibly a nuclease DNA replication, recombination, and repair 119720120 Nonpathogen - hypothetical protein Tpen_1214 2 None None None 119720670 Nonpathogen - polysaccharide biosynthesis protein Tpen_1767 2 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 119720470 Common - phosphonopyruvate decarboxylase-related protein Tpen_1567 51 COG3635 COG3635, Predicted phosphoglycerate mutase, AP superfamily Carbohydrate transport and metabolism 119718980 Common - purine and other phosphorylases, family 1 Tpen_0062 86 COG2820 Udp, Uridine phosphorylase Nucleotide transport and metabolism 119719983 Common - proton-translocating NADH-quinone oxidoreductase, chain L Tpen_1076 206 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 119720483 Common - ABC transporter related Tpen_1580 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 119720193 Nonpathogen - CRISPR-associated RAMP protein, SSO1426 family Tpen_1287 11 COG1337 COG1337, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 119718993 Nonpathogen - hypothetical protein Tpen_0075 1 None None None 119719905 Common - Cobyrinic acid a,c-diamide synthase Tpen_0997 47 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 119719940 Nonpathogen - hypothetical protein Tpen_1032 4 COG2888 COG2888, Predicted Zn-ribbon RNA-binding protein with a function in translation Translation, ribosomal structure and biogenesis 119719648 Nonpathogen - Protein of unknown function DUF460 Tpen_0738 26 COG2433 COG2433, Uncharacterized conserved protein Function unknown 119720588 Common - hypothetical protein Tpen_1685 27 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 119719408 Nonpathogen rpl7ae 50S ribosomal protein L7Ae Tpen_0493 35 COG1358 RPL8A, Ribosomal protein HS6-type (S12/L30/L7a) Translation, ribosomal structure and biogenesis 119719516 Common - protein of unknown function UPF0047 Tpen_0603 139 COG0432 COG0432, Uncharacterized conserved protein Function unknown 119719290 Common - Uncharacterized coiled-coil protein Tpen_0373 122 COG1340 COG1340, Uncharacterized archaeal coiled-coil protein Function unknown 119720176 Nonpathogen - hypothetical protein Tpen_1270 2 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 119719826 Nonpathogen - hypothetical protein Tpen_0917 1 None None None 119719286 Common - 2'-5' RNA ligase Tpen_0369 124 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 119719150 Nonpathogen - putative transcriptional regulator Tpen_0232 3 None None None 119719679 Nonpathogen - hypothetical protein Tpen_0769 3 None None None 119720421 Common - Alcohol dehydrogenase GroES domain protein Tpen_1516 172 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 119719489 Common - nicotinamide-nucleotide adenylyltransferase Tpen_0576 47 COG1056 NadR, Nicotinamide mononucleotide adenylyltransferase Coenzyme metabolism 119719910 Nonpathogen - hypothetical protein Tpen_1002 2 None None None 119719506 Nonpathogen - hypothetical protein Tpen_0593 5 None None None 119720509 Common - Rubrerythrin Tpen_1606 80 COG1592 COG1592, Rubrerythrin Energy production and conversion 119718926 Nonpathogen - hypothetical protein Tpen_0008 4 None None None 119720107 Nonpathogen - hypothetical protein Tpen_1201 1 COG1162 COG1162, Predicted GTPases General function prediction only 119720542 Nonpathogen - major facilitator superfamily MFS_1 Tpen_1639 15 None None None 119719462 Nonpathogen - 30S ribosomal protein S26e Tpen_0548 10 COG4830 RPS26B, Ribosomal protein S26 Translation, ribosomal structure and biogenesis 119720637 Nonpathogen - hypothetical protein Tpen_1734 1 COG5428 COG5428, Uncharacterized conserved small protein Function unknown 119720287 Common - Spermine synthase Tpen_1382 133 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 119719476 Common - histidine triad (HIT) protein Tpen_0562 94 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 119719081 Nonpathogen - hypothetical protein Tpen_0163 1 None None None 119719546 Nonpathogen - hypothetical protein Tpen_0635 1 None None None 119719799 Common - tryptophan synthase subunit beta Tpen_0890 225 COG1350 COG1350, Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) General function prediction only 119719607 Nonpathogen - hypothetical protein Tpen_0697 1 None None None 119719552 Common - translation initiation factor IF-2 subunit alpha Tpen_0642 37 COG1093 SUI2, Translation initiation factor 2, alpha subunit (eIF-2alpha) Translation, ribosomal structure and biogenesis 119719689 Nonpathogen - hypothetical protein Tpen_0779 1 None None None 119719968 Common - phosphate ABC transporter, inner membrane subunit PstA Tpen_1060 222 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 119719477 Common - translation initiation factor IF-2 subunit gamma Tpen_0563 249 COG5257 GCD11, Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase) Translation, ribosomal structure and biogenesis 119720295 Nonpathogen - PilT protein domain protein Tpen_1390 12 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 119720357 Common - binding-protein-dependent transport systems inner membrane component Tpen_1452 144 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 119719482 Nonpathogen - hypothetical protein Tpen_0569 1 None None None 119720443 Nonpathogen - hypothetical protein Tpen_1539 4 None None None 119719835 Nonpathogen - phosphoesterase, putative Tpen_0926 35 COG1407 COG1407, Predicted ICC-like phosphoesterases General function prediction only 119719043 Nonpathogen - hypothetical protein Tpen_0125 16 COG1590 COG1590, Uncharacterized conserved protein Function unknown 119720019 Common - galactose-1-phosphate uridylyltransferase Tpen_1112 79 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 119719712 Nonpathogen - hypothetical protein Tpen_0802 1 None None None 119720390 Common - extracellular solute-binding protein, family 1 Tpen_1485 72 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 119719163 Nonpathogen - hypothetical protein Tpen_0245 1 None None None 119719077 Nonpathogen - hypothetical protein Tpen_0159 1 None None None 119719805 Nonpathogen - sec-independent translocation protein mttA/Hcf106 Tpen_0896 3 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 119719299 Nonpathogen - hypothetical protein Tpen_0382 1 COG3091 SprT, Uncharacterized protein conserved in bacteria Function unknown 119720549 Nonpathogen - hypothetical protein Tpen_1646 3 None None None 119720021 Common - GHMP kinase Tpen_1114 109 COG0153 GalK, Galactokinase Carbohydrate transport and metabolism 119720222 Common - CRISPR-associated RAMP protein, Cmr6 family Tpen_1317 17 COG1604 COG1604, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 119720343 Nonpathogen - hypothetical protein Tpen_1438 1 None None None 119720209 Common - major facilitator superfamily MFS_1 Tpen_1303 76 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 119719889 Nonpathogen - hypothetical protein Tpen_0981 1 None None None 119719863 Nonpathogen - hypothetical protein Tpen_0955 2 None None None 119719859 Common pheT phenylalanyl-tRNA synthetase subunit beta Tpen_0951 204 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 119719129 Nonpathogen - DNA-binding protein Alba Tpen_0211 28 COG1581 Ssh10b, Archaeal DNA-binding protein Transcription 119720158 Nonpathogen - DNA polymerase, beta domain protein region Tpen_1252 7 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 119719857 Common - cysteine desulfurases, SufS subfamily Tpen_0949 243 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 119720656 Nonpathogen - hypothetical protein Tpen_1753 1 None None None 119719273 Common - tRNA-guanine transglycosylases, various specificities Tpen_0356 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 119720500 Nonpathogen - hypothetical protein Tpen_1597 13 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 119719176 Common rps4p 30S ribosomal protein S4 Tpen_0258 123 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 119719874 Nonpathogen - hypothetical protein Tpen_0966 1 None None None 119719023 Common - isochorismatase hydrolase Tpen_0105 144 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 119719401 Nonpathogen - ribosomal protein S17 Tpen_0484 34 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 119719884 Common - ferrous iron transport protein B Tpen_0976 155 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 119719658 Common - AMMECR1 domain protein Tpen_0748 76 COG2078 AMMECR1, Uncharacterized conserved protein Function unknown 119720479 Common - Extracellular ligand-binding receptor Tpen_1576 138 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 119720612 Nonpathogen - hypothetical protein Tpen_1709 5 None None None 119720129 Nonpathogen - ABC-2 type transporter Tpen_1223 1 None None None 119720151 Common - extracellular solute-binding protein, family 5 Tpen_1245 134 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 119720068 Common - metal dependent phosphohydrolase Tpen_1162 67 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 119720462 Common - L-fucose isomerase and related proteins-like Tpen_1559 10 COG2407 FucI, L-fucose isomerase and related proteins Carbohydrate transport and metabolism 119720739 Nonpathogen - hypothetical protein Tpen_1836 1 None None None 119720536 Common - SPP-like hydrolase Tpen_1633 55 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 119720392 Common - binding-protein-dependent transport systems inner membrane component Tpen_1487 220 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 119719636 Nonpathogen - hypothetical protein Tpen_0726 1 None None None 119720502 Common - major facilitator superfamily MFS_1 Tpen_1599 48 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 119719435 Nonpathogen - RNA binding S1 domain protein Tpen_0521 22 COG1096 COG1096, Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain) Translation, ribosomal structure and biogenesis 119719092 Nonpathogen - MoaD family protein Tpen_0174 6 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 119720138 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Tpen_1232 208 COG0388 COG0388, Predicted amidohydrolase General function prediction only 119719300 Common - phosphoribosyltransferase Tpen_0383 108 COG2236 COG2236, Predicted phosphoribosyltransferases General function prediction only 119719942 Nonpathogen - hypothetical protein Tpen_1034 3 None None None 119719622 Common - cobalt transport protein Tpen_0712 75 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 119719136 Common - CDP-alcohol phosphatidyltransferase Tpen_0218 118 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 119720300 Common - Pyridoxal-5'-phosphate-dependent enzyme, beta subunit Tpen_1395 219 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 119719631 Nonpathogen - hypothetical protein Tpen_0721 1 None None None 119719507 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Tpen_0594 105 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 119720665 Common - type III restriction enzyme, res subunit Tpen_1762 132 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 119720293 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Tpen_1388 145 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 119719185 Common rfc replication factor C small subunit Tpen_0267 238 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 119719571 Nonpathogen ef1B elongation factor 1-beta Tpen_0661 14 COG2092 EFB1, Translation elongation factor EF-1beta Translation, ribosomal structure and biogenesis 119720091 Common - multiple antibiotic resistance (MarC)-related proteins Tpen_1185 90 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 119719879 Nonpathogen - hypothetical protein Tpen_0971 6 None None None 119719086 Common - peptidase U62, modulator of DNA gyrase Tpen_0168 166 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 119720644 Nonpathogen - cobalt transport protein Tpen_1741 1 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 119719575 Common - hypothetical protein Tpen_0665 150 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 119720032 Common - succinate dehydrogenase and fumarate reductase iron-sulfur protein Tpen_1126 208 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 119719934 Common - dTMP kinase Tpen_1026 229 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 119719345 Nonpathogen - hypothetical protein Tpen_0428 17 COG2248 COG2248, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 119720084 Nonpathogen - metal dependent phosphohydrolase Tpen_1178 14 COG1896 COG1896, Predicted hydrolases of HD superfamily General function prediction only 119720098 Common - protein of unknown function DUF6, transmembrane Tpen_1192 42 COG2510 COG2510, Predicted membrane protein Function unknown 119720629 Common - Nucleotidyl transferase Tpen_1726 100 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 119720306 Common - transcriptional regulator, PadR-like family Tpen_1401 15 COG1695 COG1695, Predicted transcriptional regulators Transcription 119719521 Common - ribosomal protein L6 Tpen_0608 212 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 119720714 Nonpathogen - hypothetical protein Tpen_1811 1 None None None 119720565 Nonpathogen - hypothetical protein Tpen_1662 1 None None None 119719656 Nonpathogen - hypothetical protein Tpen_0746 1 None None None 119718985 Common - ABC transporter related Tpen_0067 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 119720658 Nonpathogen - von Willebrand factor, type A Tpen_1755 2 None None None 119720328 Common - formylmethanofuran dehydrogenase, subunit E region Tpen_1423 39 COG2191 COG2191, Formylmethanofuran dehydrogenase subunit E Energy production and conversion 119719099 Common - NADH ubiquinone oxidoreductase, 20 kDa subunit Tpen_0181 192 COG3260 COG3260, Ni,Fe-hydrogenase III small subunit Energy production and conversion 119719419 Common - heat shock protein Hsp20 Tpen_0504 126 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 119719245 Nonpathogen - hypothetical protein Tpen_0328 1 None None None 119718942 Nonpathogen - hypothetical protein Tpen_0024 1 None None None 119719730 Common - Alcohol dehydrogenase GroES domain protein Tpen_0821 204 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 119720560 Nonpathogen - hypothetical protein Tpen_1657 1 None None None 119720234 Nonpathogen - hypothetical protein Tpen_1329 1 None None None 119719030 Common - Phosphopyruvate hydratase Tpen_0112 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 119720182 Common - hypothetical protein Tpen_1276 16 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 119720553 Common - protein of unknown function DUF125, transmembrane Tpen_1650 32 COG1814 COG1814, Uncharacterized membrane protein Function unknown 119719974 Nonpathogen - hypothetical protein Tpen_1067 1 None None None 119720026 Nonpathogen - hypothetical protein Tpen_1120 1 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 119720202 Nonpathogen - hypothetical protein Tpen_1296 1 None None None 119718958 Common - glucose-inhibited division protein A Tpen_0040 246 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 119719742 Common - hypothetical protein Tpen_0833 5 None None None 119719945 Nonpathogen - hypothetical protein Tpen_1037 1 None None None 119720186 Nonpathogen - hypothetical protein Tpen_1280 1 None None None 119719041 Common - ABC-3 protein Tpen_0123 17 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 119719714 Common - type II secretion system protein Tpen_0805 26 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 119719872 Common - hypothetical protein Tpen_0964 18 COG3410 COG3410, Uncharacterized conserved protein Function unknown 119720688 Common - hypothetical protein Tpen_1785 14 COG3375 COG3375, Uncharacterized conserved protein Function unknown 119719770 Common - DEAD/DEAH box helicase domain protein Tpen_0861 233 COG1205 COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster General function prediction only 119720273 Nonpathogen - hypothetical protein Tpen_1368 1 None None None 119718973 Nonpathogen - hypothetical protein Tpen_0055 2 None None None 119720313 Common - Formate dehydrogenase Tpen_1408 184 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 119719001 Nonpathogen - hypothetical protein Tpen_0083 2 None None None 119719361 Nonpathogen - hypothetical protein Tpen_0444 30 COG1936 COG1936, Predicted nucleotide kinase (related to CMP and AMP kinases) Nucleotide transport and metabolism 119720374 Nonpathogen - hypothetical protein Tpen_1469 3 None None None 119719555 Nonpathogen - hypothetical protein Tpen_0645 1 None None None 119720049 Nonpathogen - hypothetical protein Tpen_1143 1 None None None 119720058 Common - extracellular solute-binding protein, family 1 Tpen_1152 104 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 119719792 Common - Xylose isomerase domain protein TIM barrel Tpen_0883 34 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 119718944 Nonpathogen - hypothetical protein Tpen_0026 3 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 119719008 Nonpathogen - helix-turn-helix domain protein Tpen_0090 21 COG2522 COG2522, Predicted transcriptional regulator General function prediction only 119720367 Common - ABC transporter related Tpen_1462 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 119720142 Common - putative transcriptional regulator, CopG family Tpen_1236 58 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 119720416 Common - Alpha-galactosidase Tpen_1511 53 COG1486 CelF, Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases Carbohydrate transport and metabolism 119720697 Common - binding-protein-dependent transport systems inner membrane component Tpen_1794 69 COG4662 TupA, ABC-type tungstate transport system, periplasmic component Coenzyme metabolism 119720579 Common - extracellular solute-binding protein, family 5 Tpen_1676 196 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 119719145 Common rpl2p 50S ribosomal protein L2P Tpen_0227 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 119719978 Common - NADH-ubiquinone oxidoreductase, chain 49kDa Tpen_1071 193 COG3261 HycE, Ni,Fe-hydrogenase III large subunit Energy production and conversion 119719374 Common - Radical SAM domain protein Tpen_0457 62 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 119719354 Common - protein of unknown function DUF711 Tpen_0437 36 COG2848 COG2848, Uncharacterized conserved protein Function unknown 119719064 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Tpen_0146 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 119720690 Common - peptidase S16, lon domain protein Tpen_1787 48 COG1750 COG1750, Archaeal serine proteases General function prediction only 119719269 Nonpathogen - RNA polymerase Rpb4 Tpen_0352 7 COG1460 COG1460, Uncharacterized protein conserved in archaea Function unknown 119719720 Nonpathogen - hypothetical protein Tpen_0811 1 COG1436 NtpG, Archaeal/vacuolar-type H+-ATPase subunit F Energy production and conversion 119719781 Nonpathogen - Pyruvoyl-dependent arginine decarboxylase Tpen_0872 29 COG1945 COG1945, Uncharacterized conserved protein Function unknown 119719987 Common - NADH dehydrogenase (ubiquinone), 30 kDa subunit Tpen_1080 28 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 119719617 Nonpathogen - helix-turn-helix domain protein Tpen_0707 10 COG1813 COG1813, Predicted transcription factor, homolog of eukaryotic MBF1 Transcription 119719517 Nonpathogen - domain of unknown function DUF1743 Tpen_0604 33 COG1571 COG1571, Predicted DNA-binding protein containing a Zn-ribbon domain General function prediction only 119719208 Nonpathogen - RNA polymerase Rpb6 Tpen_0290 31 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 119719133 Nonpathogen - hypothetical protein Tpen_0215 1 COG1617 COG1617, Uncharacterized conserved protein Function unknown 119720070 Common - hypothetical protein Tpen_1164 5 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 119719837 Nonpathogen - Abortive infection protein Tpen_0928 1 None None None 119720386 Nonpathogen - hypothetical protein Tpen_1481 2 COG2156 KdpC, K+-transporting ATPase, c chain Inorganic ion transport and metabolism 119719259 Common - V-type ATP synthase subunit A Tpen_0342 247 COG1155 NtpA, Archaeal/vacuolar-type H+-ATPase subunit A Energy production and conversion 119719536 Nonpathogen - proliferating cell nuclear antigen PcnA Tpen_0624 34 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 119719151 Nonpathogen - preprotein translocase subunit SecY Tpen_0233 35 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 119719454 Common - pyruvate/ketoisovalerate oxidoreductase, gamma subunit Tpen_0540 52 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 119718955 Nonpathogen - hypothetical protein Tpen_0037 1 None None None 119719590 Common - methionine aminopeptidase Tpen_0680 170 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 119719337 Nonpathogen rpl37e 50S ribosomal protein L37e Tpen_0420 29 COG2126 RPL37A, Ribosomal protein L37E Translation, ribosomal structure and biogenesis 119719777 Nonpathogen - hypothetical protein Tpen_0868 1 None None None 119719296 Nonpathogen - tRNA (guanine-N(2)-)-methyltransferase Tpen_0379 39 COG1867 TRM1, N2,N2-dimethylguanosine tRNA methyltransferase Translation, ribosomal structure and biogenesis 119719735 Common - phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I Tpen_0826 197 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 119719169 Nonpathogen - hypothetical protein Tpen_0251 1 COG3351 FlaD, Putative archaeal flagellar protein D/E Cell motility and secretion 119720586 Common - major facilitator superfamily MFS_1 Tpen_1683 165 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 119720515 Nonpathogen - hypothetical protein Tpen_1612 2 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 119720403 Nonpathogen - hypothetical protein Tpen_1498 22 COG4880 COG4880, Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats General function prediction only 119719841 Common - glycoside hydrolase, family 57 Tpen_0932 30 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 119719052 Nonpathogen - hypothetical protein Tpen_0134 1 None None None 119719448 Nonpathogen - hypothetical protein Tpen_0534 4 None None None 119719788 Nonpathogen - peptidase A24A, prepilin type IV Tpen_0879 1 None None None 119719394 Nonpathogen - hypothetical protein Tpen_0477 1 None None None 119720622 Common - UDP-glucose 6-dehydrogenase Tpen_1719 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 119720499 Nonpathogen - hypothetical protein Tpen_1596 2 None None None 119719235 Common - (NiFe) hydrogenase maturation protein HypF Tpen_0318 115 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 119718963 Common - Uncharacterized protein involved in formate dehydrogenase formation-like Tpen_0045 23 COG3058 FdhE, Uncharacterized protein involved in formate dehydrogenase formation Posttranslational modification, protein turnover, chaperones 119720240 Nonpathogen - hypothetical protein Tpen_1335 2 None None None 119719963 Common - extracellular solute-binding protein, family 1 Tpen_1055 103 COG2182 MalE, Maltose-binding periplasmic proteins/domains Carbohydrate transport and metabolism 119720522 Common - extracellular solute-binding protein, family 1 Tpen_1619 25 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 119719198 Nonpathogen - RNA polymerase, insert Tpen_0280 34 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 119720004 Common - PTS system sorbose subfamily IIB component Tpen_1097 36 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 119719706 Common - protein of unknown function DUF521 Tpen_0796 39 COG1679 COG1679, Uncharacterized conserved protein Function unknown 119720388 Nonpathogen - hypothetical protein Tpen_1483 1 None None None 119719256 Nonpathogen - hypothetical protein Tpen_0339 1 COG1527 NtpC, Archaeal/vacuolar-type H+-ATPase subunit C Energy production and conversion 119720003 Common - oxidoreductase domain protein Tpen_1096 183 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 119720378 Nonpathogen - hypothetical protein Tpen_1473 2 None None None 119719715 Common - Uncharacterized protein probably involved in trehalose biosynthesis-like Tpen_0806 25 COG3281 Ble, Uncharacterized protein, probably involved in trehalose biosynthesis Carbohydrate transport and metabolism 119720693 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Tpen_1790 128 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 119719358 Common - S-adenosylmethionine decarboxylase related Tpen_0441 75 COG1586 SpeD, S-adenosylmethionine decarboxylase Amino acid transport and metabolism 119718968 Nonpathogen - hypothetical protein Tpen_0050 12 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 119719225 Nonpathogen - hypothetical protein Tpen_0308 1 None None None 119719343 Nonpathogen - flap endonuclease-1 Tpen_0426 35 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 119719576 Common - DNA topoisomerase VI subunit B Tpen_0666 34 COG1389 COG1389, DNA topoisomerase VI, subunit B DNA replication, recombination, and repair 119718935 Nonpathogen - nucleoside 2-deoxyribosyltransferase Tpen_0017 4 COG3613 COG3613, Nucleoside 2-deoxyribosyltransferase Nucleotide transport and metabolism 119720345 Common - protein of unknown function DUF87 Tpen_1440 65 COG0433 COG0433, Predicted ATPase General function prediction only 119719657 Common - protein of unknown function DUF82 Tpen_0747 44 COG1656 COG1656, Uncharacterized conserved protein Function unknown 119719840 Nonpathogen - aminopeptidase Iap family-like Tpen_0931 5 COG4882 COG4882, Predicted aminopeptidase, Iap family General function prediction only 119719473 Nonpathogen - hypothetical protein Tpen_0559 1 None None None 119720284 Nonpathogen - hypothetical protein Tpen_1379 2 None None None 119719199 Common rps12P 30S ribosomal protein S12P Tpen_0281 149 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 119720088 Nonpathogen - hypothetical protein Tpen_1182 2 None None None 119720368 Nonpathogen - hypothetical protein Tpen_1463 1 None None None 119720674 Common - hypothetical protein Tpen_1771 5 None None None 119719175 Common rps11p 30S ribosomal protein S11P Tpen_0257 218 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 119719732 Common - Glyoxylate reductase Tpen_0823 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 119720363 Common - alpha amylase, catalytic region Tpen_1458 160 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 119720264 Nonpathogen - Protein of unknown function DUF1626 Tpen_1359 9 COG5493 COG5493, Uncharacterized conserved protein containing a coiled-coil domain Function unknown 119719772 Nonpathogen - putative phage repressor Tpen_0863 4 COG2932 COG2932, Predicted transcriptional regulator Transcription 119720061 Common - Kojibiose phosphorylase Tpen_1155 50 COG1554 ATH1, Trehalose and maltose hydrolases (possible phosphorylases) Carbohydrate transport and metabolism 119719646 Nonpathogen - Like-Sm ribonucleoprotein, core Tpen_0736 22 COG1958 LSM1, Small nuclear ribonucleoprotein (snRNP) homolog Transcription 119719901 Nonpathogen - hypothetical protein Tpen_0993 2 None None None 119720072 Nonpathogen - hypothetical protein Tpen_1166 3 None None None 119719784 Common - putative methylase Tpen_0875 63 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 119720415 Nonpathogen - hypothetical protein Tpen_1510 2 None None None 119719998 Common - Phosphotransferase system, phosphocarrier protein HPr Tpen_1091 140 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 119719006 Nonpathogen - hypothetical protein Tpen_0088 4 None None None 119719966 Common - phosphate ABC transporter, periplasmic phosphate-binding protein Tpen_1058 150 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 119719504 Common - hydrogenase (NiFe) small subunit HydA Tpen_0591 77 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 119720191 Nonpathogen - hypothetical protein Tpen_1285 6 None None None 119718970 Nonpathogen - hypothetical protein Tpen_0052 1 None None None 119719988 Common - NADH dehydrogenase subunit D Tpen_1081 191 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 119719088 Nonpathogen - hypothetical protein Tpen_0170 1 None None None 119719237 Common - thiamine biosynthesis protein ThiI Tpen_0320 117 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 119720045 Common - ferredoxin-dependent glutamate synthase Tpen_1139 204 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 119719271 Nonpathogen - pseudouridylate synthase Tpen_0354 33 COG1258 COG1258, Predicted pseudouridylate synthase Translation, ribosomal structure and biogenesis 119720381 Nonpathogen - hypothetical protein Tpen_1476 1 None None None 119719444 Nonpathogen - actin/actin family protein Tpen_0530 3 COG5277 COG5277, Actin and related proteins Cytoskeleton 119719641 Nonpathogen - hypothetical protein Tpen_0731 3 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 119720371 Common - UspA domain protein Tpen_1466 105 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 119719528 Common - RNA modification enzyme, MiaB family Tpen_0616 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 119718964 Common - protein of unknown function DUF89 Tpen_0046 42 COG1578 COG1578, Uncharacterized conserved protein Function unknown 119719915 Common - 5-formyltetrahydrofolate cyclo-ligase Tpen_1007 21 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 119719278 Common - glutamyl-tRNA(Gln) amidotransferase subunit D Tpen_0361 135 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 119720540 Common - binding-protein-dependent transport systems inner membrane component Tpen_1637 213 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 119719807 Common - cytidyltransferase-related domain Tpen_0898 48 COG1056 NadR, Nicotinamide mononucleotide adenylyltransferase Coenzyme metabolism 119719204 Common - DNA-directed RNA polymerase subunit beta Tpen_0286 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 119720557 Common - hypothetical protein Tpen_1654 12 COG2407 FucI, L-fucose isomerase and related proteins Carbohydrate transport and metabolism 119719691 Common - thiamine pyrophosphate enzyme domain protein TPP-binding Tpen_0781 123 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 119720547 Nonpathogen - GCN5-related N-acetyltransferase Tpen_1644 2 COG0456 RimI, Acetyltransferases General function prediction only 119720145 Nonpathogen - protein of unknown function DUF125, transmembrane Tpen_1239 1 None None None 119719432 Common - uridylate kinase, putative Tpen_0518 154 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 119719747 Nonpathogen - protein of unknown function DUF369 Tpen_0838 10 COG2164 COG2164, Uncharacterized conserved protein Function unknown 119719396 Common - sugar isomerase (SIS) Tpen_0479 47 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 119719979 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Tpen_1072 81 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 119718957 Nonpathogen - hypothetical protein Tpen_0039 1 None None None 119719282 Common - putative RNA methylase Tpen_0365 21 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 119719572 Nonpathogen - Protein of unknown function DUF1610 Tpen_0662 32 COG2888 COG2888, Predicted Zn-ribbon RNA-binding protein with a function in translation Translation, ribosomal structure and biogenesis 119719053 Common - Alpha-amylase Tpen_0135 25 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 119719244 Common - ribose 5-phosphate isomerase Tpen_0327 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 119719601 Nonpathogen - PilT protein domain protein Tpen_0691 1 COG1412 COG1412, Uncharacterized proteins of PilT N-term./Vapc superfamily General function prediction only 119719608 Nonpathogen - hypothetical protein Tpen_0698 1 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 119720716 Common - Sua5/YciO/YrdC/YwlC family protein Tpen_1813 240 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 119720464 Common - ABC-2 type transporter Tpen_1561 152 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 119720524 Nonpathogen - Bacterio-opsin activator, HTH domain protein Tpen_1621 14 COG3413 COG3413, Predicted DNA binding protein General function prediction only 119719611 Nonpathogen - hypothetical protein Tpen_0701 1 None None None 119719947 Nonpathogen - hypothetical protein Tpen_1039 1 None None None 119720669 Common - putative glutamate synthase subunit beta Tpen_1766 230 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 119719952 Common - NAD+ synthetase Tpen_1044 218 COG0171 NadE, NAD synthase Coenzyme metabolism 119719499 Nonpathogen - AAA ATPase Tpen_0586 31 COG1474 CDC6, Cdc6-related protein, AAA superfamily ATPase DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones 119720395 Common - ABC transporter related Tpen_1490 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 119720274 Nonpathogen - hypothetical protein Tpen_1369 16 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 119720685 Common - Radical SAM domain protein Tpen_1782 106 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 119719450 Common - Nucleotide binding protein, PINc Tpen_0536 56 COG1855 COG1855, ATPase (PilT family) General function prediction only 119718947 Nonpathogen - hypothetical protein Tpen_0029 1 None None None 119720514 Common - AMP-dependent synthetase and ligase Tpen_1611 199 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 119719579 Nonpathogen - hypothetical protein Tpen_0669 1 None None None 119719410 Nonpathogen rps28e 30S ribosomal protein S28e Tpen_0495 33 COG2053 RPS28A, Ribosomal protein S28E/S33 Translation, ribosomal structure and biogenesis 119719192 Common rps2P 30S ribosomal protein S2 Tpen_0274 69 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 119720485 Common - Radical SAM domain protein Tpen_1582 20 COG5014 COG5014, Predicted Fe-S oxidoreductase General function prediction only 119720551 Common - fructose-bisphosphate aldolase Tpen_1648 81 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 119720608 Common - hypothetical protein Tpen_1705 9 COG5493 COG5493, Uncharacterized conserved protein containing a coiled-coil domain Function unknown 119720640 Common - hypothetical protein Tpen_1737 65 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 119720095 Nonpathogen - hypothetical protein Tpen_1189 1 None None None 119719161 Nonpathogen - Ribosomal protein S4E, central Tpen_0243 34 COG1471 RPS4A, Ribosomal protein S4E Translation, ribosomal structure and biogenesis 119720660 Nonpathogen - hypothetical protein Tpen_1757 12 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 119719036 Common - hydrolase, TatD family Tpen_0118 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 119720625 Common - glycosyl transferase, group 1 Tpen_1722 169 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 119718952 Nonpathogen - hypothetical protein Tpen_0034 1 None None None 119719095 Common - Cellulase Tpen_0177 91 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 119719490 Common - putative transcriptional regulator, AsnC family Tpen_0577 35 COG1522 Lrp, Transcriptional regulators Transcription 119720247 Nonpathogen - putative CRISPR-associated protein, APE2256 family Tpen_1342 10 COG4006 COG4006, Uncharacterized protein conserved in archaea Function unknown 119720537 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Tpen_1634 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 119720401 Nonpathogen - hypothetical protein Tpen_1496 2 None None None 119720569 Common - dihydrodipicolinate synthase Tpen_1666 234 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 119719083 Common - protein of unknown function DUF58 Tpen_0165 72 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 119720162 Common - binding-protein-dependent transport systems inner membrane component Tpen_1256 131 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 119719877 Nonpathogen - hypothetical protein Tpen_0969 3 COG5550 COG5550, Predicted aspartyl protease Posttranslational modification, protein turnover, chaperones 119720166 Nonpathogen - Uncharacterized membrane-associated protein/domain-like Tpen_1260 3 COG2512 COG2512, Uncharacterized membrane-associated protein/domain Function unknown 119720493 Common - binding-protein-dependent transport systems inner membrane component Tpen_1590 152 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 119719752 Common - Glu/Leu/Phe/Val dehydrogenase, C terminal Tpen_0843 180 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 119718976 Nonpathogen - thioredoxin/glutaredoxin-like Tpen_0058 7 COG5494 COG5494, Predicted thioredoxin/glutaredoxin Posttranslational modification, protein turnover, chaperones 119719137 Nonpathogen - ubiquitin-associated- domain-containing protein Tpen_0219 28 COG1308 EGD2, Transcription factor homologous to NACalpha-BTF3 Transcription 119719854 Nonpathogen - hypothetical protein Tpen_0946 1 None None None 119720174 Common - PP-loop domain protein Tpen_1268 146 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 119719301 Common - translation initiation factor IF-2B subunit delta Tpen_0384 130 COG1184 GCD2, Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 119719764 Nonpathogen - hypothetical protein Tpen_0855 1 None None None 119719376 Nonpathogen - hypothetical protein Tpen_0459 1 None None None 119719367 Nonpathogen - hypothetical protein Tpen_0450 1 None None None 119720128 Common - ABC transporter related Tpen_1222 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 119720096 Nonpathogen - hypothetical protein Tpen_1190 1 None None None 119719542 Nonpathogen - nucleic acid binding, OB-fold, tRNA/helicase-type Tpen_0630 3 COG1599 RFA1, Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins DNA replication, recombination, and repair 119719865 Nonpathogen - hypothetical protein Tpen_0957 3 None None None 119719880 Nonpathogen - PaREP8 domain containing protein Tpen_0972 7 None None None 119719468 Nonpathogen - hypothetical protein Tpen_0554 1 None None None 119719550 Nonpathogen - hypothetical protein Tpen_0639 1 None None None 119719950 Common ubiA prenyltransferase Tpen_1042 54 COG1575 MenA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase Coenzyme metabolism 119720653 Common - ATPase associated with various cellular activities, AAA_3 Tpen_1750 174 COG0714 COG0714, MoxR-like ATPases General function prediction only 119719020 Nonpathogen - putative transcriptional regulator, CopG family Tpen_0102 5 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 119719105 Common - respiratory-chain NADH dehydrogenase, subunit 1 Tpen_0187 138 COG0650 HyfC, Formate hydrogenlyase subunit 4 Energy production and conversion 119719124 Nonpathogen - single-strand DNA-binding protein Tpen_0206 15 COG1599 RFA1, Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins DNA replication, recombination, and repair 119719058 Common dcd deoxycytidine triphosphate deaminase Tpen_0140 159 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 119719029 Common - metal dependent phosphohydrolase Tpen_0111 19 COG3294 COG3294, Uncharacterized conserved protein Function unknown 119720616 Nonpathogen - hypothetical protein Tpen_1713 3 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 119720200 Nonpathogen - hypothetical protein Tpen_1294 1 None None None 119719620 Nonpathogen - Transcription factor TFIIE, alpha subunit Tpen_0710 32 COG1675 TFA1, Transcription initiation factor IIE, alpha subunit Transcription 119720110 Nonpathogen - hypothetical protein Tpen_1204 1 None None None 119719331 Nonpathogen - DNA-directed RNA polymerase subunit E, RpoE2 Tpen_0414 32 COG2093 COG2093, DNA-directed RNA polymerase, subunit E'' Transcription 119719153 Nonpathogen rpl30p 50S ribosomal protein L30P Tpen_0235 34 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 119719336 Nonpathogen - 154aa long hypothetical protein Tpen_0419 12 COG4080 COG4080, RecB-family nuclease DNA replication, recombination, and repair 119719535 Nonpathogen - DNA primase, large subunit Tpen_0623 26 COG2219 PRI2, Eukaryotic-type DNA primase, large subunit DNA replication, recombination, and repair 119720224 Nonpathogen - CRISPR-associated protein, Cmr5 family Tpen_1319 2 COG3337 COG3337, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 119719740 Nonpathogen - hypothetical protein Tpen_0831 1 None None None 119719654 Nonpathogen - hypothetical protein Tpen_0744 1 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 119719893 Common - helicase domain protein Tpen_0985 169 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 119719810 Common - ROK family protein Tpen_0901 173 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 119719371 Nonpathogen - NMD3 Tpen_0454 32 COG1499 NMD3, NMD protein affecting ribosome stability and mRNA decay Translation, ribosomal structure and biogenesis 119719842 Nonpathogen - hypothetical protein Tpen_0933 3 None None None 119720229 Nonpathogen - hypothetical protein Tpen_1324 2 None None None 119719754 Nonpathogen - hypothetical protein Tpen_0845 1 None None None 119719856 Common - Thymidylate synthase-like Tpen_0948 28 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 119720454 Common - extracellular solute-binding protein, family 1 Tpen_1550 19 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 119720350 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Tpen_1445 206 COG0388 COG0388, Predicted amidohydrolase General function prediction only 119719051 Nonpathogen - cytochrome c biogenesis protein, transmembrane region Tpen_0133 1 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 119719749 Nonpathogen - Auxin Efflux Carrier Tpen_0840 6 COG0679 COG0679, Predicted permeases General function prediction only 119720153 Common - binding-protein-dependent transport systems inner membrane component Tpen_1247 218 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 119720358 Common - extracellular solute-binding protein, family 1 Tpen_1453 119 COG2182 MalE, Maltose-binding periplasmic proteins/domains Carbohydrate transport and metabolism 119720504 Nonpathogen - hypothetical protein Tpen_1601 1 None None None 119719437 Common - NAD(+) kinase Tpen_0523 228 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 119719220 Nonpathogen - flap endonuclease-1 Tpen_0302 34 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 119719292 Nonpathogen - gar1 - like small nucleolar rnp Tpen_0375 5 COG3277 GAR1, RNA-binding protein involved in rRNA processing Translation, ribosomal structure and biogenesis 119719110 Nonpathogen - transcriptional regulator, Fis family Tpen_0192 1 COG2005 ModE, N-terminal domain of molybdenum-binding protein General function prediction only 119720741 Nonpathogen - hypothetical protein Tpen_1838 1 None None None 119720143 Common - YbaK/prolyl-tRNA synthetase associated region Tpen_1237 83 COG2606 EbsC, Uncharacterized conserved protein Function unknown 119719961 Common - MoeA domain protein, domain I and II Tpen_1053 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 119720111 Common - ABC transporter related Tpen_1205 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 119719687 Nonpathogen - type II secretion system protein Tpen_0777 13 COG1955 FlaJ, Archaeal flagella assembly protein J Cell motility and secretion / Intracellular trafficking and secretion 119720526 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Tpen_1623 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 119719168 Common - Galactose-1-phosphate uridylyltransferase-like Tpen_0250 21 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 119719885 Nonpathogen - hypothetical protein Tpen_0977 4 None None None 119719794 Common - DNA topoisomerase Tpen_0885 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 119720080 Common - extracellular solute-binding protein, family 1 Tpen_1174 34 COG2182 MalE, Maltose-binding periplasmic proteins/domains Carbohydrate transport and metabolism 119720330 Common - transport system permease protein Tpen_1425 187 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 119718990 Nonpathogen - hypothetical protein Tpen_0072 1 None None None 119720177 Common - beta-lactamase domain protein Tpen_1271 58 COG1237 COG1237, Metal-dependent hydrolases of the beta-lactamase superfamily II General function prediction only 119719066 Common - binding-protein-dependent transport systems inner membrane component Tpen_0148 218 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 119719071 Nonpathogen - phosphoadenosine phosphosulfate reductase Tpen_0153 13 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 119719469 Common - putative RNA methylase Tpen_0555 37 COG0116 COG0116, Predicted N6-adenine-specific DNA methylase DNA replication, recombination, and repair 119720423 Nonpathogen - phosphoesterase, DHHA1 Tpen_1518 9 COG2404 COG2404, Predicted phosphohydrolase (DHH superfamily) General function prediction only 119719670 Nonpathogen - Redoxin domain protein Tpen_0760 2 None None None 119720261 Nonpathogen - CRISPR-associated autoregulator, DevR family Tpen_1356 14 COG1857 COG1857, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 119719672 Common - undecaprenyl diphosphate synthase Tpen_0762 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 119720695 Nonpathogen - hypothetical protein Tpen_1792 7 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 119720117 Nonpathogen - monomethylamine methyltransferase Tpen_1211 2 None None None 119720102 Common - amino acid permease-associated region Tpen_1196 186 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 119719456 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Tpen_0542 113 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 119719206 Common - glycyl-tRNA synthetase Tpen_0288 88 COG0423 GRS1, Glycyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 119719480 Nonpathogen - hypothetical protein Tpen_0567 6 None None None 119719592 Common - Deoxyribonuclease V Tpen_0682 73 COG1515 Nfi, Deoxyinosine 3'endonuclease (endonuclease V) DNA replication, recombination, and repair 119720025 Common - cation diffusion facilitator family transporter Tpen_1119 174 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 119719277 Common - glutamyl-tRNA(Gln) amidotransferase subunit E Tpen_0360 214 COG2511 GatE, Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain) Translation, ribosomal structure and biogenesis 119719475 Nonpathogen - protein of unknown function DUF402 Tpen_0561 16 None None None 119719903 Nonpathogen - hypothetical protein Tpen_0995 2 COG1433 COG1433, Uncharacterized conserved protein Function unknown 119719252 Common - anaerobic ribonucleoside triphosphate reductase Tpen_0335 89 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 119719048 Common - isoleucyl-tRNA synthetase Tpen_0130 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 119720672 Nonpathogen - hypothetical protein Tpen_1769 2 None None None 119719446 Nonpathogen - hypothetical protein Tpen_0532 1 None None None 119719100 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Tpen_0182 189 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 119719560 Nonpathogen - hypothetical protein Tpen_0650 10 COG1645 COG1645, Uncharacterized Zn-finger containing protein General function prediction only 119719817 Common - MRP protein-like Tpen_0908 233 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 119718933 Nonpathogen - hypothetical protein Tpen_0015 1 None None None 119719860 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Tpen_0952 59 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 119719924 Nonpathogen - 30S ribosomal protein S25e Tpen_1016 9 COG4901 COG4901, Ribosomal protein S25 Translation, ribosomal structure and biogenesis 119719722 Nonpathogen - H+-transporting two-sector ATPase, E subunit Tpen_0813 5 COG1390 NtpE, Archaeal/vacuolar-type H+-ATPase subunit E Energy production and conversion 119719402 Nonpathogen - Ribonuclease P, Rpp29 Tpen_0486 23 COG1588 POP4, RNase P/RNase MRP subunit p29 Translation, ribosomal structure and biogenesis 119719661 Nonpathogen - hypothetical protein Tpen_0751 4 None None None 119720620 Common - glycosyl transferase, group 1 Tpen_1717 227 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 119719323 Nonpathogen - hypothetical protein Tpen_0406 1 COG2443 Sss1, Preprotein translocase subunit Sss1 Intracellular trafficking and secretion 119719115 Common - ATPase, P-type (transporting), HAD superfamily, subfamily IC Tpen_0197 232 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 119719779 Nonpathogen - hypothetical protein Tpen_0870 3 None None None 119719943 Common - hypothetical protein Tpen_1035 44 COG4260 COG4260, Putative virion core protein (lumpy skin disease virus) Function unknown 119719348 Nonpathogen - Ribosomal LX protein Tpen_0431 14 COG2157 RPL20A, Ribosomal protein L20A (L18A) Translation, ribosomal structure and biogenesis 119719899 Nonpathogen - DNA polymerase, beta domain protein region Tpen_0991 11 COG5260 TRF4, DNA polymerase sigma DNA replication, recombination, and repair 119719939 Common - Methyltransferase type 11 Tpen_1031 36 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 119720196 Nonpathogen - metal dependent phosphohydrolase Tpen_1290 3 COG1353 COG1353, Predicted hydrolase of the HD superfamily (permuted catalytic motifs) General function prediction only 119720236 Nonpathogen - hypothetical protein Tpen_1331 1 None None None 119720473 Common - Peroxidase Tpen_1570 227 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 119719602 Nonpathogen - hypothetical protein Tpen_0692 21 COG2403 COG2403, Predicted GTPase General function prediction only 119719955 Nonpathogen - 4-vinyl reductase, 4VR Tpen_1047 1 COG1719 COG1719, Predicted hydrocarbon binding protein (contains V4R domain) General function prediction only 119720347 Nonpathogen - hypothetical protein Tpen_1442 2 COG3432 COG3432, Predicted transcriptional regulator Transcription 119719824 Common - hypothetical protein Tpen_0915 31 COG0778 NfnB, Nitroreductase Energy production and conversion 119719870 Nonpathogen - hypothetical protein Tpen_0962 1 None None None 119720011 Common - cobalt transport protein Tpen_1104 33 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 119720709 Common - ABC transporter related Tpen_1806 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 119720219 Nonpathogen - Quinolinate phosphoribosyl transferase Tpen_1314 12 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 119719242 Common - valyl-tRNA synthetase Tpen_0325 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 119719858 Common pheS phenylalanyl-tRNA synthetase subunit alpha Tpen_0950 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 119720571 Common - protein of unknown function DUF1393 Tpen_1668 15 COG4720 COG4720, Predicted membrane protein Function unknown 119719909 Common - HhH-GPD family protein Tpen_1001 232 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 119719564 Common - phosphoesterase, DHHA1 Tpen_0654 30 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 119720311 Nonpathogen - hypothetical protein Tpen_1406 3 COG2898 COG2898, Uncharacterized conserved protein Function unknown 119720210 Nonpathogen - hypothetical protein Tpen_1304 1 None None None 119719384 Common - Methyltransferase type 11 Tpen_0467 65 COG2519 GCD14, tRNA(1-methyladenosine) methyltransferase and related methyltransferases Translation, ribosomal structure and biogenesis 119719666 Nonpathogen - hypothetical protein Tpen_0756 2 COG1531 COG1531, Uncharacterized protein conserved in archaea Function unknown 119719316 Nonpathogen - hypothetical protein Tpen_0399 1 None None None 119719107 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Tpen_0189 168 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 119720018 Nonpathogen - Uncharacterized membrane-associated protein/domain-like Tpen_1111 5 COG2512 COG2512, Uncharacterized membrane-associated protein/domain Function unknown 119720466 Common - putative circadian clock protein, KaiC Tpen_1563 56 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 119720631 Nonpathogen - hypothetical protein Tpen_1728 2 None None None 119719267 Nonpathogen - hypothetical protein Tpen_0350 1 None None None 119719585 Nonpathogen - hypothetical protein Tpen_0675 1 None None None 119719729 Common - Xylose isomerase domain protein TIM barrel Tpen_0820 51 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 119719932 Nonpathogen - hypothetical protein Tpen_1024 1 None None None 119719567 Nonpathogen - hypothetical protein Tpen_0657 1 None None None 119719696 Common - lysyl-tRNA synthetase Tpen_0786 76 COG1384 LysS, Lysyl-tRNA synthetase (class I) Translation, ribosomal structure and biogenesis 119720627 Common - glycosyl transferase, group 1 Tpen_1724 218 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 119719216 Common - DNA polymerase I Tpen_0298 63 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 119720646 Common - glycosyl transferase, group 1 Tpen_1743 34 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 119720326 Nonpathogen - hypothetical protein Tpen_1421 1 None None None 119719004 Common - sugar-phosphate nucleotidyl transferase Tpen_0086 59 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 119720292 Common - alpha/beta hydrolase fold Tpen_1387 140 COG2267 PldB, Lysophospholipase Lipid metabolism 119719013 Nonpathogen - thiamineS protein Tpen_0095 1 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 119719556 Nonpathogen - hypothetical protein Tpen_0646 1 None None None 119720413 Common - hydrogenase maturation protease Tpen_1508 15 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 119719373 Common - putative circadian clock protein, KaiC Tpen_0456 63 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 119720411 Common - cytochrome bd ubiquinol oxidase, subunit I Tpen_1506 153 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 119720556 Common - major facilitator superfamily MFS_1 Tpen_1653 146 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 119720277 Common - Alkylglycerone-phosphate synthase Tpen_1372 193 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 119720683 Nonpathogen - hypothetical protein Tpen_1780 2 None None None 119720633 Common - glycosyl transferase, family 2 Tpen_1730 195 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 119720074 Common - transglutaminase domain protein Tpen_1168 75 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 119720373 Common - Methionine synthase Tpen_1468 167 COG5012 COG5012, Predicted cobalamin binding protein General function prediction only 119719442 Nonpathogen - hypothetical protein Tpen_0528 1 None None None 119720718 Common - putative signal-transduction protein with CBS domains Tpen_1815 32 COG0517 COG0517, FOG: CBS domain General function prediction only 119719391 Nonpathogen - translation initiation factor IF-6 Tpen_0474 33 COG1976 TIF6, Translation initiation factor 6 (eIF-6) Translation, ribosomal structure and biogenesis 119719472 Nonpathogen - hypothetical protein Tpen_0558 1 None None None 119719202 Common - DNA-directed RNA polymerase, subunit A'' Tpen_0284 232 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 119719295 Nonpathogen - helix-turn-helix domain protein Tpen_0378 31 COG1395 COG1395, Predicted transcriptional regulator Transcription 119720147 Common - sugar-phosphate isomerases, RpiB/LacA/LacB family Tpen_1241 128 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 119719365 Nonpathogen - Ribosomal protein S24e Tpen_0448 25 COG2004 RPS24A, Ribosomal protein S24E Translation, ribosomal structure and biogenesis 119720316 Nonpathogen - hypothetical protein Tpen_1411 3 None None None 119720720 Common - Aldehyde ferredoxin oxidoreductase Tpen_1817 58 COG2414 COG2414, Aldehyde:ferredoxin oxidoreductase Energy production and conversion 119718966 Nonpathogen - transcriptional regulator, Fis family Tpen_0048 1 None None None 119719351 Nonpathogen - hypothetical protein Tpen_0434 1 None None None 119720299 Common - protein of unknown function DUF87 Tpen_1394 89 COG0433 COG0433, Predicted ATPase General function prediction only 119720495 Nonpathogen - glycosyl transferase, group 1 Tpen_1592 29 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 119719847 Nonpathogen - hypothetical protein Tpen_0939 1 COG4343 COG4343, Uncharacterized protein conserved in archaea Function unknown 119719194 Nonpathogen - DNA-directed RNA polymerase subunit N Tpen_0276 34 COG1644 RPB10, DNA-directed RNA polymerase, subunit N (RpoN/RPB10) Transcription 119719254 Common - V-type ATPase, 116 kDa subunit Tpen_0337 48 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 119720408 Nonpathogen - hypothetical protein Tpen_1503 1 None None None 119719708 Common - phage SPO1 DNA polymerase-related protein Tpen_0798 151 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 119720382 Nonpathogen - PilT protein domain protein Tpen_1477 4 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 119719141 Common - ribosomal protein L1 Tpen_0223 248 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 119719539 Nonpathogen - Ribosomal protein L34e Tpen_0627 17 COG2174 RPL34A, Ribosomal protein L34E Translation, ribosomal structure and biogenesis 119720015 Nonpathogen - hypothetical protein Tpen_1108 1 None None None 119719332 Nonpathogen - DNA-directed RNA polymerase subunit E' Tpen_0415 34 COG1095 RPB7, DNA-directed RNA polymerase, subunit E' Transcription 119719613 Common - Radical SAM domain protein Tpen_0703 152 COG1964 COG1964, Predicted Fe-S oxidoreductases General function prediction only 119720054 Common - orotate phosphoribosyltransferase Tpen_1148 179 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 119719341 Nonpathogen - translation initiation factor eIF-1A Tpen_0424 34 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 119719701 Common - glycoside hydrolase, family 57 Tpen_0791 14 COG1543 COG1543, Uncharacterized conserved protein Function unknown 119720276 Nonpathogen - hypothetical protein Tpen_1371 1 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 119718951 Nonpathogen - hypothetical protein Tpen_0033 3 COG1592 COG1592, Rubrerythrin Energy production and conversion 119720064 Common - aspartate carbamoyltransferase regulatory subunit Tpen_1158 64 COG1781 PyrI, Aspartate carbamoyltransferase, regulatory subunit Nucleotide transport and metabolism 119719936 Nonpathogen - hypothetical protein Tpen_1028 1 None None None 119720139 Nonpathogen - Haloacid dehalogenase domain protein hydrolase Tpen_1233 18 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 119719148 Common rpl3p 50S ribosomal protein L3P Tpen_0230 154 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 119720245 Nonpathogen - transcriptional regulator, AbrB family Tpen_1340 4 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 119719131 Nonpathogen - DNA-directed RNA polymerase, M/15 kDa subunit Tpen_0213 7 COG1594 RPB9, DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS Transcription 119720397 Common - hypothetical protein Tpen_1492 105 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 119720506 Nonpathogen - hypothetical protein Tpen_1603 2 None None None 119719635 Nonpathogen - ATPases involved in chromosome partitioning-like Tpen_0725 1 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 119719583 Nonpathogen - hypothetical protein Tpen_0673 1 None None None 119720577 Nonpathogen - hypothetical protein Tpen_1674 3 None None None 119720365 Common - protein of unknown function DUF1130 Tpen_1460 38 COG5483 COG5483, Uncharacterized conserved protein Function unknown 119719739 Common - protein of unknown function DUF107 Tpen_0830 40 COG1030 NfeD, Membrane-bound serine protease (ClpP class) Posttranslational modification, protein turnover, chaperones 119718928 Common - adenylate kinases Tpen_0010 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 119720093 Nonpathogen - PilT protein domain protein Tpen_1187 5 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 119719496 Nonpathogen - Shwachman-Bodian-Diamond syndrome protein Tpen_0583 34 COG1500 COG1500, Predicted exosome subunit Translation, ribosomal structure and biogenesis 119719181 Common - Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein Tpen_0263 133 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 119719852 Common - aldo/keto reductase Tpen_0944 195 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 119720567 Common - aminotransferase, class I and II Tpen_1664 241 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 119720539 Common - binding-protein-dependent transport systems inner membrane component Tpen_1636 218 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 119719439 Nonpathogen - hypothetical protein Tpen_0525 3 COG2892 COG2892, Uncharacterized protein conserved in archaea Function unknown 119720303 Nonpathogen - ABC-2 type transporter Tpen_1398 42 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 119719026 Nonpathogen - hypothetical protein Tpen_0108 2 None None None 119720164 Common - formate dehydrogenase family accessory protein FdhD Tpen_1258 132 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 119720562 Nonpathogen - tyrosyl-tRNA synthetase Tpen_1659 38 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 119719420 Common - translation initiation factor SUI1 Tpen_0505 77 COG0023 SUI1, Translation initiation factor 1 (eIF-1/SUI1) and related proteins Translation, ribosomal structure and biogenesis 119720647 Common - glycosyl transferase, group 1 Tpen_1744 163 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 119720339 Nonpathogen - hypothetical protein Tpen_1434 2 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 119718921 Common - conserved hypothetical 2-acetyl-1-alkylglycerophosph ocholine esterase Tpen_0003 94 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 119719097 Nonpathogen - hypothetical protein Tpen_0179 1 None None None 119719427 Common - protein of unknown function RIO1 Tpen_0513 66 COG1718 RIO1, Serine/threonine protein kinase involved in cell cycle control Signal transduction mechanisms / Cell division and chromosome partitioning 119719417 Common - GTP-binding signal recognition particle SRP54, G- domain Tpen_0502 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 119720448 Common - ABC transporter related Tpen_1544 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 119720623 Common - Nucleotidyl transferase Tpen_1720 231 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 119719303 Common - ribose-phosphate pyrophosphokinase Tpen_0386 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 119719378 Common - putative rRNA pseudouridine synthase Tpen_0461 240 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 119719745 Common - regulatory protein, ArsR Tpen_0836 21 COG1777 COG1777, Predicted transcriptional regulators Transcription 119719750 Common - peptidase T2, asparaginase 2 Tpen_0841 84 COG1446 COG1446, Asparaginase Amino acid transport and metabolism 119720441 Common - threonine synthase Tpen_1537 195 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 119720168 Common - ATPase, AAA superfamily Tpen_1262 51 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 119720530 Nonpathogen - hypothetical protein Tpen_1627 1 None None None 119719970 Nonpathogen - amidohydrolase Tpen_1063 2 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 119720559 Common - NUDIX hydrolase Tpen_1656 93 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 119720711 Common - extracellular solute-binding protein, family 1 Tpen_1808 53 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 119718989 Common - Radical SAM domain protein Tpen_0071 42 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 119720596 Nonpathogen - protein of unknown function DUF86 Tpen_1693 3 COG2445 COG2445, Uncharacterized conserved protein Function unknown 119719034 Common - Methyltransferase type 11 Tpen_0116 17 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 119719398 Nonpathogen - hypothetical protein Tpen_0481 1 None None None 119720207 Nonpathogen - DNA polymerase, beta domain protein region Tpen_1301 10 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 119720324 Common - ABC transporter related Tpen_1419 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 119718931 Common - binding-protein-dependent transport systems inner membrane component Tpen_0013 120 COG4986 COG4986, ABC-type anion transport system, duplicated permease component Inorganic ion transport and metabolism 119719627 Common - oxidoreductase domain protein Tpen_0717 137 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 119720730 Nonpathogen - hypothetical protein Tpen_1827 2 None None None 119719954 Common - phosphonopyruvate decarboxylase-related protein Tpen_1046 55 COG3635 COG3635, Predicted phosphoglycerate mutase, AP superfamily Carbohydrate transport and metabolism 119719808 Common - ribonuclease HII Tpen_0899 67 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 119720512 Nonpathogen - PilT protein domain protein Tpen_1609 2 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 119720667 Nonpathogen - hypothetical protein Tpen_1764 1 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 119720124 Common - peptidase M48, Ste24p Tpen_1218 187 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 119720266 Nonpathogen - hypothetical protein Tpen_1361 4 COG1353 COG1353, Predicted hydrolase of the HD superfamily (permuted catalytic motifs) General function prediction only 119720254 Common - Xylose isomerase domain protein TIM barrel Tpen_1349 15 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 119719188 Nonpathogen - hypothetical protein Tpen_0270 2 COG4190 COG4190, Predicted transcriptional regulator Transcription 119719497 Common - proteasome subunit alpha Tpen_0584 36 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 119719717 Common - type II secretion system protein E Tpen_0808 185 COG0630 VirB11, Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis Cell motility and secretion / Intracellular trafficking and secretion 119720487 Common - ATPase Tpen_1584 13 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 119719759 Common - ferrous iron transport protein B Tpen_0850 224 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 119719230 Common - molybdenum cofactor biosynthesis protein C Tpen_0313 196 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 119720023 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Tpen_1117 1 None None None 119719822 Common - ABC transporter related Tpen_0913 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 119719914 Common - iron-containing alcohol dehydrogenase Tpen_1006 173 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 119720489 Common - pyrrolidone-carboxylate peptidase Tpen_1586 56 COG2039 Pcp, Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase) Posttranslational modification, protein turnover, chaperones 119719056 Common - protein of unknown function DUF72 Tpen_0138 116 COG1801 COG1801, Uncharacterized conserved protein Function unknown 119720352 Common - ABC transporter related Tpen_1447 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 119719275 Nonpathogen - 30S ribosomal protein S8e Tpen_0358 34 COG2007 RPS8A, Ribosomal protein S8E Translation, ribosomal structure and biogenesis 119720283 Nonpathogen - hypothetical protein Tpen_1378 8 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 119720205 Nonpathogen - hypothetical protein Tpen_1299 3 None None None 119719265 Nonpathogen - Transcription factor CBF/NF-Y histone Tpen_0348 9 COG2036 HHT1, Histones H3 and H4 Chromatin structure and dynamics 119719425 Common - Methyltransferase type 11 Tpen_0511 20 COG2521 COG2521, Predicted archaeal methyltransferase General function prediction only 119719073 Common - biotin/lipoyl attachment domain-containing protein Tpen_0155 145 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 119720199 Nonpathogen - protein of unknown function DUF324 Tpen_1293 3 COG1337 COG1337, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 119720710 Common - binding-protein-dependent transport systems inner membrane component Tpen_1807 207 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 119719559 Nonpathogen - ZPR1-related zinc finger protein Tpen_0649 29 COG1779 COG1779, C4-type Zn-finger protein General function prediction only 119719511 Common - ABC transporter related Tpen_0598 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 119720425 Common - thioesterase superfamily protein Tpen_1520 28 COG5496 COG5496, Predicted thioesterase General function prediction only 119719685 Common - heat shock protein Hsp20 Tpen_0775 21 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 119719849 Common - beta-lactamase domain protein Tpen_0941 72 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 119719126 Common - ornithine cyclodeaminase Tpen_0208 93 COG2423 COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog Amino acid transport and metabolism 119720104 Common - TrkA-N domain protein Tpen_1198 171 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 119720427 Nonpathogen - hypothetical protein Tpen_1522 1 None None None 119719674 Common - hypothetical protein Tpen_0764 206 COG3425 PksG, 3-hydroxy-3-methylglutaryl CoA synthase Lipid metabolism 119720031 Nonpathogen - succinate dehydrogenase cytochrome b-556 subunit Tpen_1125 2 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 119720436 Common - phosphoenolpyruvate carboxykinase Tpen_1532 59 COG1274 PckA, Phosphoenolpyruvate carboxykinase (GTP) Energy production and conversion 119720077 Nonpathogen - hypothetical protein Tpen_1171 1 None None None 119720452 Common - binding-protein-dependent transport systems inner membrane component Tpen_1548 126 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 119720256 Common - Abortive infection protein Tpen_1351 10 None None None 119719174 Nonpathogen - hypothetical protein Tpen_0256 1 None None None 119720126 Nonpathogen - hypothetical protein Tpen_1220 1 None None None 119720248 Common - Chromosome segregation ATPases-like Tpen_1343 11 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 119719239 Nonpathogen - hypothetical protein Tpen_0322 1 None None None 119719831 Nonpathogen - hypothetical protein Tpen_0922 1 None None None 119719544 Common - geranylgeranylglyceryl phosphate synthase-like protein Tpen_0633 40 COG1646 COG1646, Predicted phosphate-binding enzymes, TIM-barrel fold General function prediction only 119719867 Nonpathogen - transcriptional regulator, AbrB family Tpen_0959 1 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 119720681 Common - glycosyl transferase, group 1 Tpen_1778 145 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 119719261 Nonpathogen - hypothetical protein Tpen_0344 1 None None None 119719801 Nonpathogen - hypothetical protein Tpen_0892 1 None None None 119720243 Nonpathogen - CRISPR-associated protein DxTHG motif Tpen_1338 4 COG1517 COG1517, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 119719061 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Tpen_0143 249 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 119719992 Nonpathogen - NADH-ubiquinone oxidoreductase, chain 4L Tpen_1085 2 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 119720510 Nonpathogen - hypothetical protein Tpen_1607 2 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 119718923 Common - ABC transporter related Tpen_0005 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 119720009 Nonpathogen - phosphoribosyltransferase Tpen_1102 11 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 119720406 Nonpathogen - PaREP8 domain containing protein Tpen_1501 6 None None None 119720519 Common - carbohydrate kinase, FGGY Tpen_1616 177 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 119720318 Common - Aldehyde ferredoxin oxidoreductase Tpen_1413 56 COG2414 COG2414, Aldehyde:ferredoxin oxidoreductase Energy production and conversion 119720446 Common - paREP7 Tpen_1542 42 COG4372 COG4372, Uncharacterized protein conserved in bacteria with the myosin-like domain Function unknown 119720000 Common - N-acetylglucosamine-6-phosphate deacetylase Tpen_1093 118 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 119719533 Common - beta-lactamase domain protein Tpen_0621 81 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 119720700 Common - transporter Tpen_1797 6 COG4956 COG4956, Integral membrane protein (PIN domain superfamily) General function prediction only 119719179 Nonpathogen - hypothetical protein Tpen_0261 1 None None None 119720651 Common - hypothetical protein Tpen_1748 31 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 119720226 Common - CRISPR-associated protein Cas1 Tpen_1321 34 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 119719338 Nonpathogen - Like-Sm ribonucleoprotein, core Tpen_0421 31 COG1958 LSM1, Small nuclear ribonucleoprotein (snRNP) homolog Transcription 119720618 Common - UDP-N-acetylglucosamine 2-epimerase Tpen_1715 151 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 119720450 Nonpathogen - hypothetical protein Tpen_1546 1 None None None 119719212 Common - ribosomal-protein-alanine acetyltransferase Tpen_0294 131 COG0456 RimI, Acetyltransferases General function prediction only 119720349 Common - NAD+ synthetase Tpen_1444 236 COG0171 NadE, NAD synthase Coenzyme metabolism 119720136 Common - flavin reductase domain protein, FMN-binding Tpen_1230 39 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 119719386 Nonpathogen - hypothetical protein Tpen_0469 1 None None None 119720459 Common - binding-protein-dependent transport systems inner membrane component Tpen_1555 181 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 119719897 Common - Protein of unknown function DUF1626 Tpen_0989 53 COG5493 COG5493, Uncharacterized conserved protein containing a coiled-coil domain Function unknown 119719694 Nonpathogen - transcriptional regulator, PadR-like family Tpen_0784 1 COG1695 COG1695, Predicted transcriptional regulators Transcription 119719018 Nonpathogen - peptidase, zinc-dependent Tpen_0100 30 COG1913 COG1913, Predicted Zn-dependent proteases General function prediction only 119720036 Nonpathogen - ATPase Tpen_1130 10 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 119719938 Common - Threonyl/alanyl tRNA synthetase, SAD Tpen_1030 170 COG2872 COG2872, Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain General function prediction only 119720083 Common - ABC transporter related Tpen_1177 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 119720605 Nonpathogen - hypothetical protein Tpen_1702 2 None None None 119719120 Nonpathogen - zinc finger, SWIM domain protein Tpen_0202 1 None None None 119718999 Common - aminotransferase, class I and II Tpen_0081 241 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 119719594 Nonpathogen - peptidyl-tRNA hydrolase Tpen_0684 34 COG1990 COG1990, Uncharacterized conserved protein Function unknown 119719250 Nonpathogen - hypothetical protein Tpen_0333 1 None None None 119720581 Common - binding-protein-dependent transport systems inner membrane component Tpen_1678 213 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 119720598 Nonpathogen - hypothetical protein Tpen_1695 1 None None None 119719488 Common - reverse gyrase Tpen_0575 241 COG1110 COG1110, Reverse gyrase DNA replication, recombination, and repair 119719540 Common - aspartyl-tRNA synthetase Tpen_0628 249 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 119719109 Common - formate/nitrite transporter Tpen_0191 94 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 119719223 Common - peptidylprolyl isomerase, FKBP-type Tpen_0305 49 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 119719869 Common - hypothetical protein Tpen_0961 22 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 119719044 Common - purine and other phosphorylases, family 1 Tpen_0126 99 COG2820 Udp, Uridine phosphorylase Nucleotide transport and metabolism 119719727 Common - ribosomal-protein-alanine acetyltransferase Tpen_0818 212 COG0456 RimI, Acetyltransferases General function prediction only 119719819 Common - extracellular solute-binding protein, family 1 Tpen_0910 132 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 119719404 Common - ribosomal protein S3 Tpen_0488 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 119719085 Common - adenylate kinases Tpen_0167 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 119719766 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Tpen_0857 106 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 119718919 Common - phosphoesterase, PA-phosphatase related Tpen_0001 12 None None None 119719078 Common - methylated-DNA--protein-cysteine methyltransferase Tpen_0160 216 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 119719466 Nonpathogen - transcriptional regulator, HxlR family Tpen_0552 1 COG4742 COG4742, Predicted transcriptional regulator Transcription 119720475 Common - protein of unknown function DUF87 Tpen_1572 102 COG0433 COG0433, Predicted ATPase General function prediction only 119719922 Common - DEAD/DEAH box helicase domain protein Tpen_1014 236 COG1201 Lhr, Lhr-like helicases General function prediction only 119720067 Common - dihydroorotate dehydrogenase family protein Tpen_1161 192 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 119719665 Common - Radical SAM domain protein Tpen_0755 22 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 119720722 Nonpathogen - Methionine synthase, vitamin-B12 independent Tpen_1819 10 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 119719957 Nonpathogen - Protein of unknown function DUF998 Tpen_1049 8 COG3371 COG3371, Predicted membrane protein Function unknown 119719562 Common - type III restriction enzyme, res subunit Tpen_0652 141 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 119720155 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Tpen_1249 249 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 119720238 Common - ABC transporter related Tpen_1333 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 119719604 Nonpathogen - dephospho-CoA kinase Tpen_0694 36 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 119719240 Nonpathogen - hypothetical protein Tpen_0323 1 None None None 119719949 Common - NUDIX hydrolase Tpen_1041 49 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 119720016 Common - major facilitator superfamily MFS_1 Tpen_1109 200 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 119720518 Common - hydrogenase formation HypD protein Tpen_1615 109 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 119720594 Nonpathogen - DNA polymerase, beta domain protein region Tpen_1691 12 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 119719975 Common - GCN5-related N-acetyltransferase Tpen_1068 31 COG0456 RimI, Acetyltransferases General function prediction only 119720008 Common - HAD-superfamily hydrolase, subfamily IIB Tpen_1101 56 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 119719087 Common - peptidase U62, modulator of DNA gyrase Tpen_0169 166 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 119720468 Nonpathogen - hypothetical protein Tpen_1565 1 None None None 119720187 Nonpathogen - hypothetical protein Tpen_1281 1 None None None 119720603 Nonpathogen - PaREP8 domain containing protein Tpen_1700 6 None None None 119720566 Common - cyclase family protein Tpen_1663 114 COG1878 COG1878, Predicted metal-dependent hydrolase General function prediction only 119719653 Nonpathogen - Rad51-like Tpen_0743 34 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 119719111 Nonpathogen - hypothetical protein Tpen_0193 1 None None None 119719605 Nonpathogen - hypothetical protein Tpen_0695 24 COG1931 COG1931, Uncharacterized protein conserved in archaea Function unknown 119719743 Nonpathogen - hypothetical protein Tpen_0834 1 None None None 119720528 Common - hypothetical protein Tpen_1625 6 None None None 119719057 Nonpathogen - Protein of unknown function DUF429 Tpen_0139 14 COG2410 COG2410, Uncharacterized conserved protein Function unknown 119719596 Common - protein of unknown function DUF699, ATPase putative Tpen_0686 48 COG1444 COG1444, Predicted P-loop ATPase fused to an acetyltransferase General function prediction only 119720689 Common - glycerophosphoryl diester phosphodiesterase Tpen_1786 137 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 119719864 Nonpathogen - Water Stress and Hypersensitive response Tpen_0956 2 COG5608 COG5608, Conserved secreted protein Function unknown 119719610 Common - putative RNA methylase Tpen_0700 37 COG1041 COG1041, Predicted DNA modification methylase DNA replication, recombination, and repair 119718986 Common - ABC transporter, permease protein Tpen_0068 24 COG4721 COG4721, Predicted membrane protein Function unknown 119720183 Nonpathogen - DNA polymerase, beta domain protein region Tpen_1277 2 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 119719033 Common - transcriptional regulator, PadR-like family Tpen_0115 42 COG1695 COG1695, Predicted transcriptional regulators Transcription 119719494 Common - exosome complex exonuclease 1 Tpen_0581 233 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 119719426 Nonpathogen - KH, type 1, domain protein Tpen_0512 34 COG1094 COG1094, Predicted RNA-binding protein (contains KH domains) General function prediction only 119720267 Nonpathogen - CRISPR-associated RAMP protein, Csm5 family Tpen_1362 2 None None None 119719375 Common - metal dependent phosphohydrolase Tpen_0458 87 COG1078 COG1078, HD superfamily phosphohydrolases General function prediction only 119720666 Nonpathogen - protein of unknown function DUF134 Tpen_1763 6 COG1342 COG1342, Predicted DNA-binding proteins General function prediction only 119720736 Common - asparagine synthetase A Tpen_1833 134 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 119719251 Nonpathogen - bis(5'nucleosyl)-tetraphosphatase, ApaH Tpen_0334 14 COG0639 ApaH, Diadenosine tetraphosphatase and related serine/threonine protein phosphatases Signal transduction mechanisms 119719009 Common - 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases-like Tpen_0091 110 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 119720391 Common - ABC transporter related Tpen_1486 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 119719353 Nonpathogen - hypothetical protein Tpen_0436 1 None None None 119719501 Common - phosphoenolpyruvate synthase Tpen_0588 235 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 119720030 Common - putative succinate dehydrogenase cytochrome b subunit Tpen_1124 6 COG2142 SdhD, Succinate dehydrogenase, hydrophobic anchor subunit Energy production and conversion 119720114 Common - sugar binding protein of ABC transporter Tpen_1208 73 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 119719703 Nonpathogen - hypothetical protein Tpen_0793 13 COG1318 COG1318, Predicted transcriptional regulators Transcription 119720545 Common - multiple antibiotic resistance (MarC)-related proteins Tpen_1642 157 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 119720085 Common - UbiA prenyltransferase Tpen_1179 23 COG1575 MenA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase Coenzyme metabolism 119719760 Common - anaerobic ribonucleoside-triphosphate reductase activating protein Tpen_0851 54 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 119720733 Nonpathogen - Desulfoferrodoxin, ferrous iron-binding region Tpen_1830 19 COG2033 COG2033, Desulfoferrodoxin Energy production and conversion 119719436 Nonpathogen - hypothetical protein Tpen_0522 2 COG3286 COG3286, Uncharacterized protein conserved in archaea Function unknown 119720257 Common - DEAD/DEAH box helicase domain protein Tpen_1352 237 COG1201 Lhr, Lhr-like helicases General function prediction only 119720533 Common - protein of unknown function DUF84 Tpen_1630 34 COG1986 COG1986, Uncharacterized conserved protein Function unknown 119719625 Common - translation-associated GTPase Tpen_0715 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 119720682 Common - zinc/iron permease Tpen_1779 109 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 119719091 Common - putative transcriptional regulator, ModE family Tpen_0173 91 COG2005 ModE, N-terminal domain of molybdenum-binding protein General function prediction only 119719554 Nonpathogen rpl44e 50S ribosomal protein L44e Tpen_0644 19 COG1631 RPL42A, Ribosomal protein L44E Translation, ribosomal structure and biogenesis 119720090 Nonpathogen - hypothetical protein Tpen_1184 1 None None None 119719306 Nonpathogen - Protein of unknown function DUF54 Tpen_0389 24 COG1325 COG1325, Predicted exosome subunit Translation, ribosomal structure and biogenesis 119718941 Nonpathogen - hypothetical protein Tpen_0023 1 None None None 119720561 Common - Rhomboid family protein Tpen_1658 156 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 119720713 Common - metallophosphoesterase Tpen_1810 20 COG1409 Icc, Predicted phosphohydrolases General function prediction only 119719693 Nonpathogen - monooxygenase, FAD-binding Tpen_0783 34 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 119720039 Nonpathogen - Haloacid dehalogenase domain protein hydrolase Tpen_1133 2 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 119719789 Common - triosephosphate isomerase Tpen_0880 74 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 119720141 Common - Radical SAM domain protein Tpen_1235 69 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 119720364 Nonpathogen - DNA polymerase, beta domain protein region Tpen_1459 12 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 119720384 Common - potassium-transporting ATPase subunit A Tpen_1479 96 COG2060 KdpA, K+-transporting ATPase, A chain Inorganic ion transport and metabolism 119720280 Common - FAD dependent oxidoreductase Tpen_1375 98 COG0579 COG0579, Predicted dehydrogenase General function prediction only 119720399 Common - glycoside hydrolase, family 3 domain protein Tpen_1494 130 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 119719447 Nonpathogen - hypothetical protein Tpen_0533 1 None None None 119720078 Common - ABC transporter related Tpen_1172 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 119719209 Common - thermosome Tpen_0291 246 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 119720703 Common - ATP-dependent protease La Tpen_1800 29 COG4930 COG4930, Predicted ATP-dependent Lon-type protease Posttranslational modification, protein turnover, chaperones 119719832 Common - PP-loop domain protein Tpen_0923 160 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 119719776 Common - protein of unknown function DUF354 Tpen_0867 21 COG1817 COG1817, Uncharacterized protein conserved in archaea Function unknown 119720583 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Tpen_1680 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 119719101 Common - NADH dehydrogenase (ubiquinone), 30 kDa subunit Tpen_0183 198 COG3261 HycE, Ni,Fe-hydrogenase III large subunit Energy production and conversion 119719736 Common - Nucleotidyl transferase Tpen_0827 193 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 119719871 Nonpathogen - hypothetical protein Tpen_0963 1 None None None 119719171 Common - protein of unknown function, ATP binding Tpen_0253 34 COG2229 COG2229, Predicted GTPase General function prediction only 119719362 Nonpathogen - type II secretion system protein Tpen_0445 21 COG1955 FlaJ, Archaeal flagella assembly protein J Cell motility and secretion / Intracellular trafficking and secretion 119719098 Common - hydrogenase 4 subunit D Tpen_0180 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 119720387 Nonpathogen - hypothetical protein Tpen_1482 10 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 119720554 Nonpathogen - protein of unknown function UPF0153 Tpen_1651 13 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 119720496 Common - daunorubicin resistance ABC transporter, inner membrane subunit B Tpen_1593 206 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 119718960 Nonpathogen - dual specificity protein phosphatase Tpen_0042 3 COG2453 CDC14, Predicted protein-tyrosine phosphatase Signal transduction mechanisms 119720439 Common - cobalt transport protein Tpen_1535 38 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 119719645 Nonpathogen - hypothetical protein Tpen_0735 1 None None None 119720297 Nonpathogen - hypothetical protein Tpen_1392 4 None None None 119718994 Common - 6-phosphogluconate dehydrogenase, NAD-binding Tpen_0076 160 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 119720372 Nonpathogen - trimethylamine methyltransferase Tpen_1467 12 COG5598 COG5598, Trimethylamine:corrinoid methyltransferase Coenzyme metabolism 119719782 Nonpathogen - hypothetical protein Tpen_0873 2 None None None 119719344 Common - DNA ligase I, ATP-dependent Dnl1 Tpen_0427 106 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 119720071 Common - ABC transporter related Tpen_1165 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 119719393 Common - Thiamine-phosphate kinase Tpen_0476 192 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 119720575 Common - Glycoside hydrolase, family 42, N-terminal domain protein Tpen_1672 16 COG3934 COG3934, Endo-beta-mannanase Carbohydrate transport and metabolism 119720723 Common - molybdopterin-guanine dinucleotide biosynthesis protein B Tpen_1820 74 COG1763 MobB, Molybdopterin-guanine dinucleotide biosynthesis protein Coenzyme metabolism 119719415 Nonpathogen - Ribosomal protein L24E Tpen_0500 30 COG2075 RPL24A, Ribosomal protein L24E Translation, ribosomal structure and biogenesis 119720602 Nonpathogen - hypothetical protein Tpen_1699 2 None None None 119719524 Nonpathogen - PfkB domain protein Tpen_0612 11 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 119720290 Nonpathogen - major facilitator superfamily MFS_1 Tpen_1385 2 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 119719134 Common - protein of unknown function DUF62 Tpen_0216 74 COG1912 COG1912, Uncharacterized conserved protein Function unknown 119720309 Common - ABC transporter related Tpen_1404 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 119719844 Common - FAD dependent oxidoreductase Tpen_0935 113 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 119719200 Nonpathogen - NusA family KH domain protein Tpen_0282 32 COG0195 NusA, Transcription elongation factor Transcription 119719002 Nonpathogen - hypothetical protein Tpen_0084 1 None None None 119718938 Nonpathogen - hypothetical protein Tpen_0020 1 None None None 119720046 Common - asparagine synthetase A Tpen_1140 149 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 119719297 Nonpathogen - Translation initiation factor IF5 Tpen_0380 34 COG1601 GCD7, Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain Translation, ribosomal structure and biogenesis 119719459 Common - RNA methyltransferase, TrmH family, group 1 Tpen_0545 152 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 119720375 Common - Radical SAM domain protein Tpen_1470 82 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 119720419 Nonpathogen - hypothetical protein Tpen_1514 1 None None None 119720059 Nonpathogen - glycosidase, PH1107-related Tpen_1153 10 COG2152 COG2152, Predicted glycosylase Carbohydrate transport and metabolism 119720740 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Tpen_1837 152 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 119720278 Common - carbohydrate kinase, FGGY Tpen_1373 174 COG0554 GlpK, Glycerol kinase Energy production and conversion 119719803 Common - Glycerol kinase Tpen_0894 183 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 119719195 Common rps9p 30S ribosomal protein S9P Tpen_0277 248 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 119720402 Common - peptidase U34, dipeptidase Tpen_1497 23 COG4690 PepD, Dipeptidase Amino acid transport and metabolism 119719072 Common - hypothetical protein Tpen_0154 104 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 119720621 Nonpathogen - glycosyl transferase, family 39 Tpen_1718 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 119719919 Common - Radical SAM domain protein Tpen_1011 106 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 119720014 Common - putative ATP binding protein Tpen_1107 46 COG2102 COG2102, Predicted ATPases of PP-loop superfamily General function prediction only 119719215 Nonpathogen - hypothetical protein Tpen_0297 2 None None None 119719921 Common - oxidoreductase domain protein Tpen_1013 185 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 119719452 Common - putative transcriptional regulator, XRE family Tpen_0538 37 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 119719920 Nonpathogen - hypothetical protein Tpen_1012 1 None None None 119720148 Nonpathogen - hypothetical protein Tpen_1242 1 None None None 119718983 Nonpathogen - hypothetical protein Tpen_0065 1 None None None 119719984 Common - NADH dehydrogenase (quinone) Tpen_1077 206 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 119719197 Nonpathogen - 50S ribosomal protein L18e Tpen_0279 34 COG1727 RPL18A, Ribosomal protein L18E Translation, ribosomal structure and biogenesis 119720029 Common - Polysulphide reductase, NrfD Tpen_1123 8 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 119719662 Common - PfkB domain protein Tpen_0752 205 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 119720676 Nonpathogen - hypothetical protein Tpen_1773 5 None None None 119719063 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Tpen_0145 249 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 119719616 Nonpathogen - PUA domain containing protein Tpen_0706 29 COG1370 COG1370, Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit Posttranslational modification, protein turnover, chaperones 119719241 Nonpathogen - protein of unknown function DUF437 Tpen_0324 12 COG2411 COG2411, Uncharacterized conserved protein Function unknown 119718925 Common - cobalt transport protein Tpen_0007 46 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 119720444 Nonpathogen - hypothetical protein Tpen_1540 4 None None None 119719959 Nonpathogen - GHMP kinase Tpen_1051 1 COG1829 COG1829, Predicted archaeal kinase (sugar kinase superfamily) General function prediction only 119719813 Common - ABC transporter related Tpen_0904 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 119719457 Common - thiamine pyrophosphate enzyme domain protein TPP-binding Tpen_0543 109 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 119719246 Nonpathogen - Protein of unknown function DUF431 Tpen_0329 8 COG2428 COG2428, Uncharacterized conserved protein Function unknown 119719046 Nonpathogen - hypothetical protein Tpen_0128 2 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 119720041 Nonpathogen - major facilitator superfamily MFS_1 Tpen_1135 5 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 119720457 Common - spermidine/putrescine ABC transporter ATPase subunit Tpen_1553 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 119719319 Nonpathogen - hypothetical protein Tpen_0402 1 None None None 119720197 Nonpathogen - protein of unknown function DUF324 Tpen_1291 3 COG1337 COG1337, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 119720216 Nonpathogen - hypothetical protein Tpen_1311 19 COG1992 COG1992, Uncharacterized conserved protein Function unknown 119719312 Nonpathogen - hypothetical protein Tpen_0395 9 None None None 119719471 Nonpathogen - ribosome biogenesis protein Tpen_0557 18 COG1756 Mra1, Uncharacterized conserved protein Function unknown 119719563 Nonpathogen - 30S ribosomal protein S3Ae Tpen_0653 34 COG1890 RPS1A, Ribosomal protein S3AE Translation, ribosomal structure and biogenesis 119718972 Nonpathogen - hypothetical protein Tpen_0054 2 None None None 119719011 Common - putative thymidine phosphorylase Tpen_0093 144 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 119719352 Nonpathogen - hypothetical protein Tpen_0435 2 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 119719313 Nonpathogen - hypothetical protein Tpen_0396 1 None None None 119719068 Common - putative transcriptional regulator, AsnC family Tpen_0150 157 COG1522 Lrp, Transcriptional regulators Transcription 119719589 Common - AAA family ATPase, CDC48 subfamily Tpen_0679 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 119719329 Common - glycosyl transferase, family 4 Tpen_0412 190 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 119720494 Common - transcriptional regulator, TrmB Tpen_1591 40 COG1378 COG1378, Predicted transcriptional regulators Transcription 119719486 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Tpen_0573 112 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 119719328 Nonpathogen - hypothetical protein Tpen_0411 1 None None None 119720322 Common - aminotransferase, class I and II Tpen_1417 237 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 119720642 Common - cobalamin (vitamin B12) biosynthesis CbiM protein Tpen_1739 90 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 119719211 Nonpathogen - TATA-box binding Tpen_0293 34 COG2101 SPT15, TATA-box binding protein (TBP), component of TFIID and TFIIIB Transcription 119720203 Common - glycoside hydrolase, family 20 Tpen_1297 16 COG3525 Chb, N-acetyl-beta-hexosaminidase Carbohydrate transport and metabolism 119720638 Nonpathogen - hypothetical protein Tpen_1735 3 None None None 119719898 Common - protein of unknown function DUF74 Tpen_0990 104 COG0393 COG0393, Uncharacterized conserved protein Function unknown 119719918 Nonpathogen - ATP-cone domain protein Tpen_1010 3 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 119719139 Common alaS alanyl-tRNA synthetase Tpen_0221 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 119719405 Nonpathogen - ribosomal protein L22 Tpen_0489 33 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 119720432 Common - peptidase S1 and S6, chymotrypsin/Hap Tpen_1528 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 119720461 Nonpathogen - permease, major facilitator superfamily Tpen_1558 4 None None None 119719389 Nonpathogen - ribosomal protein L39e Tpen_0472 4 COG2167 RPL39, Ribosomal protein L39E Translation, ribosomal structure and biogenesis 119720409 Nonpathogen - hypothetical protein Tpen_1504 1 None None None 119719725 Common gltX glutamyl-tRNA synthetase Tpen_0816 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 119719862 Nonpathogen - hypothetical protein Tpen_0954 1 None None None 119720611 Nonpathogen - transcriptional regulator/antitoxin, MazE Tpen_1708 5 COG2336 MazE, Growth regulator Signal transduction mechanisms 119720680 Nonpathogen - Methyltransferase type 11 Tpen_1777 23 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 119720157 Nonpathogen - hypothetical protein Tpen_1251 5 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 119719875 Nonpathogen - hypothetical protein Tpen_0967 1 None None None 119720429 Nonpathogen - hypothetical protein Tpen_1525 1 None None None 119719711 Nonpathogen - hypothetical protein Tpen_0801 2 COG5283 COG5283, Phage-related tail protein Function unknown 119719906 Nonpathogen - DNA polymerase, beta domain protein region Tpen_0998 4 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 119719848 Nonpathogen - hypothetical protein Tpen_0940 1 None None None 119720687 Nonpathogen - zinc finger, SWIM domain protein Tpen_1784 2 None None None 119720020 Nonpathogen - hypothetical protein Tpen_1113 2 None None None 119720619 Common - methyltransferase FkbM family Tpen_1716 70 COG2520 COG2520, Predicted methyltransferase General function prediction only 119720610 Nonpathogen - hypothetical protein Tpen_1707 1 None None None 119719113 Nonpathogen - GTPase or GTP-binding protein Tpen_0195 17 COG1341 COG1341, Predicted GTPase or GTP-binding protein General function prediction only 119720476 Common - metallophosphoesterase Tpen_1573 101 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 119719758 Nonpathogen - FeoA family protein Tpen_0849 22 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 119720715 Common - DEAD_2 domain protein Tpen_1812 87 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 119720724 Common - short chain dehydrogenase Tpen_1821 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 119720231 Nonpathogen - hypothetical protein Tpen_1326 1 None None None 119720065 Common - dihydroorotase, multifunctional complex type Tpen_1159 209 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 119720340 Nonpathogen - hypothetical protein Tpen_1435 3 None None None 119720006 Common - hypothetical protein Tpen_1099 12 None None None 119719463 Nonpathogen - protein of unknown function DUF358 Tpen_0549 10 COG1901 COG1901, Uncharacterized conserved protein Function unknown 119719633 Nonpathogen - hypothetical protein Tpen_0723 1 None None None 119719335 Nonpathogen - hypothetical protein Tpen_0418 1 None None None 119719538 Common - cytidylate kinase Tpen_0626 47 COG1102 Cmk, Cytidylate kinase Nucleotide transport and metabolism 119719912 Common - stationary-phase survival protein SurE Tpen_1004 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 119720053 Common - orotidine 5'-phosphate decarboxylase Tpen_1147 48 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 119719836 Common - hydroxymethylglutaryl-CoA reductase, degradative Tpen_0927 51 COG1257 HMG1, Hydroxymethylglutaryl-CoA reductase Lipid metabolism 119720221 Nonpathogen - hypothetical protein Tpen_1316 14 COG1353 COG1353, Predicted hydrolase of the HD superfamily (permuted catalytic motifs) General function prediction only 119720252 Common - protein of unknown function DUF917 Tpen_1347 31 COG3535 COG3535, Uncharacterized conserved protein Function unknown 119720657 Common - von Willebrand factor, type A Tpen_1754 42 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 119719164 Common - eIF-2B alpha/beta/delta-related uncharacterized proteins Tpen_0246 132 COG0182 COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 119720134 Common - Radical SAM domain protein Tpen_1228 80 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 119719606 Common - ribonuclease Z Tpen_0696 91 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 119719449 Nonpathogen - DNA-binding protein Alba Tpen_0535 28 COG1581 Ssh10b, Archaeal DNA-binding protein Transcription 119719796 Nonpathogen - hypothetical protein Tpen_0887 1 None None None 119719827 Nonpathogen - hypothetical protein Tpen_0918 1 None None None 119719272 Nonpathogen - 50S ribosomal protein L21e Tpen_0355 26 COG2139 RPL21A, Ribosomal protein L21E Translation, ribosomal structure and biogenesis 119720334 Nonpathogen - Protein of unknown function DUF1626 Tpen_1429 6 COG5493 COG5493, Uncharacterized conserved protein containing a coiled-coil domain Function unknown 119720123 Common - protein of unknown function DUF72 Tpen_1217 28 COG1801 COG1801, Uncharacterized conserved protein Function unknown 119719074 Common - carboxyl transferase Tpen_0156 216 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 119720508 Common - Pyridoxal-5'-phosphate-dependent enzyme, beta subunit Tpen_1605 219 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 119719883 Nonpathogen - FeoA family protein Tpen_0975 25 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 119720354 Nonpathogen - UbiA prenyltransferase Tpen_1449 36 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 119719263 Nonpathogen - peptidase M48, Ste24p Tpen_0346 3 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 119720691 Nonpathogen - hypothetical protein Tpen_1788 1 None None None 119720630 Common - glycosyl transferase, family 2 Tpen_1727 151 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 119719156 Nonpathogen rpl19e 50S ribosomal protein L19e Tpen_0238 34 COG2147 RPL19A, Ribosomal protein L19E Translation, ribosomal structure and biogenesis 119719483 Common - histone deacetylase superfamily Tpen_0570 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 119720543 Common - amino acid permease-associated region Tpen_1640 167 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 119719513 Common - inner-membrane translocator Tpen_0600 102 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 119719232 Nonpathogen - MoaD family protein Tpen_0315 11 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 119719423 Common - putative agmatinase Tpen_0509 158 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 119719681 Nonpathogen - hypothetical protein Tpen_0771 1 None None None 119719676 Common - protein of unknown function DUF35 Tpen_0766 60 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 119719547 Common ubiA prenyltransferase Tpen_0636 71 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 119719683 Common - Phosphoglycerate kinase Tpen_0773 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 119720286 Nonpathogen - AAA ATPase Tpen_1381 4 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 119720420 Nonpathogen - hypothetical protein Tpen_1515 1 COG3388 COG3388, Uncharacterized protein conserved in archaea Function unknown 119719289 Common - Orotidine 5'-phosphate decarboxylase Tpen_0372 47 COG0269 SgbH, 3-hexulose-6-phosphate synthase and related proteins Carbohydrate transport and metabolism 119719688 Common - Amidohydrolase 3 Tpen_0778 109 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 119719774 Nonpathogen - Metal-dependent hydrolases of the beta-lactamase superfamily II-like Tpen_0865 8 COG1237 COG1237, Metal-dependent hydrolases of the beta-lactamase superfamily II General function prediction only 119719508 Common - hydrogenase expression/synthesis, HypA Tpen_0595 52 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 119720099 Common - Threonyl/alanyl tRNA synthetase, SAD Tpen_1193 213 COG2872 COG2872, Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain General function prediction only 119720643 Nonpathogen - cobalamin biosynthesis protein Tpen_1740 4 None None None 119719933 Nonpathogen - hypothetical protein Tpen_1025 1 None None None 119720106 Nonpathogen - hypothetical protein Tpen_1200 1 None None None 119720269 Common - CRISPR-associated RAMP protein, Csm3 family Tpen_1364 29 COG1337 COG1337, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 119719413 Common - DEAD/DEAH box helicase domain protein Tpen_0498 145 COG1204 COG1204, Superfamily II helicase General function prediction only 119720033 Common - FAD dependent oxidoreductase Tpen_1127 136 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 119719630 Nonpathogen - hypothetical protein Tpen_0720 2 COG0433 COG0433, Predicted ATPase General function prediction only 119720455 Common - transcriptional regulator, TrmB Tpen_1551 18 COG1378 COG1378, Predicted transcriptional regulators Transcription 119719411 Nonpathogen - Protein of unknown function DUF1288 Tpen_0496 1 COG1711 COG1711, Uncharacterized protein conserved in archaea Function unknown 119719049 Common - protein of unknown function DUF72 Tpen_0131 91 COG1801 COG1801, Uncharacterized conserved protein Function unknown 119719969 Common - ABC transporter related Tpen_1061 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 119720735 Nonpathogen - protein of unknown function DUF6, transmembrane Tpen_1832 6 COG2510 COG2510, Predicted membrane protein Function unknown 119719762 Nonpathogen - Wyosine base formation Tpen_0853 33 COG0731 COG0731, Fe-S oxidoreductases Energy production and conversion 119718936 Common - putative transcriptional regulator, AsnC family Tpen_0018 175 COG1522 Lrp, Transcriptional regulators Transcription 119719308 Common - small GTP-binding protein Tpen_0391 144 COG1084 COG1084, Predicted GTPase General function prediction only 119719941 Nonpathogen - hypothetical protein Tpen_1033 4 None None None 119720069 Common - CTP synthetase Tpen_1163 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 119720535 Nonpathogen - 4-vinyl reductase, 4VR Tpen_1632 3 COG1719 COG1719, Predicted hydrocarbon binding protein (contains V4R domain) General function prediction only 119719623 Common - ABC transporter related Tpen_0713 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 119719820 Common - binding-protein-dependent transport systems inner membrane component Tpen_0911 193 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 119719170 Nonpathogen - hypothetical protein Tpen_0252 1 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 119720521 Common - binding-protein-dependent transport systems inner membrane component Tpen_1618 181 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 119718978 Common - purine and other phosphorylases, family 1 Tpen_0060 104 COG2820 Udp, Uridine phosphorylase Nucleotide transport and metabolism 119719135 Common - RNA-3'-phosphate cyclase Tpen_0217 47 COG0430 RCL1, RNA 3'-terminal phosphate cyclase RNA processing and modification 119719093 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Tpen_0175 75 COG1148 HdrA, Heterodisulfide reductase, subunit A and related polyferredoxins Energy production and conversion 119720329 Common - periplasmic binding protein Tpen_1424 56 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 119719130 Common - putative ATPase RIL Tpen_0212 249 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 119720738 Nonpathogen - protein of unknown function DUF369 Tpen_1835 6 COG2164 COG2164, Uncharacterized conserved protein Function unknown 119719973 Common - ParB domain protein nuclease Tpen_1066 15 COG1475 Spo0J, Predicted transcriptional regulators Transcription 119720262 Nonpathogen - hypothetical protein Tpen_1357 1 None None None 119720609 Nonpathogen - hypothetical protein Tpen_1706 3 COG5550 COG5550, Predicted aspartyl protease Posttranslational modification, protein turnover, chaperones 119718959 Common - Radical SAM domain protein Tpen_0041 106 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 119719491 Nonpathogen - hypothetical protein Tpen_0578 15 COG1909 COG1909, Uncharacterized protein conserved in archaea Function unknown 119720320 Nonpathogen - DNA polymerase, beta domain protein region Tpen_1415 3 COG1708 COG1708, Predicted nucleotidyltransferases General function prediction only 119720404 Nonpathogen - transcriptional regulator, TrmB Tpen_1499 5 COG4189 COG4189, Predicted transcriptional regulator Transcription 119720201 Nonpathogen - hypothetical protein Tpen_1295 1 None None None 119719713 Nonpathogen - hypothetical protein Tpen_0804 1 None None None 119720516 Common - hydrogenase expression/formation protein HypE Tpen_1613 157 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 119719207 Nonpathogen - hypothetical protein Tpen_0289 3 None None None 119719040 Common - ABC transporter related Tpen_0122 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 119719000 Nonpathogen - hypothetical protein Tpen_0082 1 None None None 119719055 Common - elongation factor Tu, domain 2 protein Tpen_0137 247 COG5258 GTPBP1, GTPase General function prediction only 119719574 Nonpathogen - hypothetical protein Tpen_0664 3 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 119719395 Common - DEAD_2 domain protein Tpen_0478 46 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 119720185 Nonpathogen - Queuine tRNA-ribosyltransferases contain PUA domain-like Tpen_1279 9 COG1549 COG1549, Queuine tRNA-ribosyltransferases, contain PUA domain Translation, ribosomal structure and biogenesis 119719778 Nonpathogen - putative transcriptional regulator, AsnC family Tpen_0869 21 COG1522 Lrp, Transcriptional regulators Transcription 119719731 Common - Creatininase Tpen_0822 76 COG1402 COG1402, Uncharacterized protein, putative amidase General function prediction only 119720301 Nonpathogen - HEPN domain protein Tpen_1396 7 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 119719445 Nonpathogen - hypothetical protein Tpen_0531 2 None None None 119719866 Common - AAA ATPase Tpen_0958 110 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 119719293 Nonpathogen - Pre-mRNA processing ribonucleoprotein, binding region Tpen_0376 34 COG1498 SIK1, Protein implicated in ribosomal biogenesis, Nop56p homolog Translation, ribosomal structure and biogenesis 119720307 Nonpathogen - hypothetical protein Tpen_1402 4 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 119720393 Common - biotin--acetyl-CoA-carboxylase ligase Tpen_1488 213 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 119719650 Common - metallophosphoesterase Tpen_0740 19 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 119719520 Common - aspartate/glutamate/uridylate kinase Tpen_0607 39 COG1608 COG1608, Predicted archaeal kinase General function prediction only 119719031 Common - Nucleotidyl transferase Tpen_0113 221 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 119719977 Common - NADH-quinone oxidoreductase, B subunit Tpen_1070 192 COG3260 COG3260, Ni,Fe-hydrogenase III small subunit Energy production and conversion 119718984 Common - cobalt transport protein Tpen_0066 28 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 119719184 Common - replication factor C large subunit Tpen_0266 134 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 119720296 Common - beta-lactamase domain protein Tpen_1391 58 COG1237 COG1237, Metal-dependent hydrolases of the beta-lactamase superfamily II General function prediction only 119720600 Nonpathogen - DNA polymerase, beta domain protein region Tpen_1697 2 COG5260 TRF4, DNA polymerase sigma DNA replication, recombination, and repair 119719643 Nonpathogen - hypothetical protein Tpen_0733 1 None None None 119720698 Common - ABC transporter related Tpen_1795 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 119720573 Common - aldo/keto reductase Tpen_1670 206 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 119720181 Nonpathogen - hypothetical protein Tpen_1275 4 None None None 119720417 Nonpathogen - hypothetical protein Tpen_1512 1 None None None 119720662 Nonpathogen - hypothetical protein Tpen_1759 2 None None None 119719065 Common - binding-protein-dependent transport systems inner membrane component Tpen_0147 183 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 119720241 Nonpathogen - DNA polymerase, beta domain protein region Tpen_1336 1 None None None 119719769 Nonpathogen - regulatory protein, ArsR Tpen_0860 5 COG3398 COG3398, Uncharacterized protein conserved in archaea Function unknown 119719228 Nonpathogen - tRNA intron endonuclease domain protein Tpen_0311 21 COG1676 SEN2, tRNA splicing endonuclease Translation, ribosomal structure and biogenesis 119719355 Nonpathogen - hypothetical protein Tpen_0438 4 COG2019 AdkA, Archaeal adenylate kinase Nucleotide transport and metabolism 119718962 Common - peptidase U62, modulator of DNA gyrase Tpen_0044 159 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 119719618 Common - small GTP-binding protein Tpen_0708 210 COG2262 HflX, GTPases General function prediction only 119719518 Nonpathogen - hypothetical protein Tpen_0605 1 None None None 119719780 Nonpathogen - AAA ATPase Tpen_0871 31 COG1474 CDC6, Cdc6-related protein, AAA superfamily ATPase DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones 119720664 Common - protein of unknown function DUF790 Tpen_1761 25 COG3372 COG3372, Uncharacterized conserved protein Function unknown 119719453 Common - 4-aminobutyrate aminotransferase Tpen_0539 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 119719258 Common - V-type ATP synthase subunit B Tpen_0341 247 COG1156 NtpB, Archaeal/vacuolar-type H+-ATPase subunit B Energy production and conversion 119720159 Nonpathogen - protein of unknown function DUF86 Tpen_1253 3 COG2445 COG2445, Uncharacterized conserved protein Function unknown 119719793 Common - KH, type 1, domain protein Tpen_0884 184 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 119719591 Nonpathogen - Translin Tpen_0681 24 COG2178 COG2178, Predicted RNA-binding protein of the translin family Translation, ribosomal structure and biogenesis 119720498 Common - transcriptional regulator, PadR-like family Tpen_1595 19 COG1695 COG1695, Predicted transcriptional regulators Transcription 119719580 Nonpathogen - hypothetical protein Tpen_0670 1 None None None 119720048 Nonpathogen - hypothetical protein Tpen_1142 1 None None None 119720377 Nonpathogen - PilT protein domain protein Tpen_1472 3 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 119720057 Common - binding-protein-dependent transport systems inner membrane component Tpen_1151 150 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 119720491 Common - extracellular solute-binding protein, family 1 Tpen_1588 79 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 119718945 Common - alanine aminotransferase Tpen_0027 241 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 119719268 Nonpathogen - hypothetical protein Tpen_0351 1 None None None 119720366 Nonpathogen - hypothetical protein Tpen_1461 3 None None None 119719144 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Tpen_0226 219 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 119719964 Common - binding-protein-dependent transport systems inner membrane component Tpen_1056 149 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 119719570 Common - bifunctional phosphoglucose/phosphomannose isomerase Tpen_0660 20 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 119720005 Nonpathogen - PTS system fructose subfamily IIA component Tpen_1098 1 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 119720050 Common - putative circadian clock protein, KaiC Tpen_1144 110 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 119719980 Common - respiratory-chain NADH dehydrogenase, subunit 1 Tpen_1073 180 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 119719705 Nonpathogen - cytochrome c biogenesis protein, transmembrane region Tpen_0795 6 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 119719639 Nonpathogen - hypothetical protein Tpen_0729 1 None None None 119720480 Common - inner-membrane translocator Tpen_1577 122 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 119720705 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Tpen_1802 113 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 119719526 Nonpathogen - hypothetical protein Tpen_0614 1 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 119719369 Common - O-sialoglycoprotein endopeptidase Tpen_0452 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 119719734 Nonpathogen - N-glycosylase/DNA lyase Tpen_0825 12 COG4047 COG4047, Uncharacterized protein conserved in archaea Function unknown 119719838 Nonpathogen - hypothetical protein Tpen_0929 2 COG3601 COG3601, Predicted membrane protein Function unknown 119720564 Nonpathogen - hypothetical protein Tpen_1661 8 COG4879 COG4879, Uncharacterized protein conserved in archaea Function unknown 119720361 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Tpen_1456 108 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 119719986 Common - NADH-quinone oxidoreductase, B subunit Tpen_1079 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 119720671 Common - NUDIX hydrolase Tpen_1768 162 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 119719741 Common - band 7 protein Tpen_0832 217 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 119720312 Nonpathogen - hypothetical protein Tpen_1407 2 None None None 119720063 Common pyrB aspartate carbamoyltransferase catalytic subunit Tpen_1157 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 119720585 Nonpathogen - HEPN domain protein Tpen_1682 2 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 119719360 Nonpathogen - hypothetical protein Tpen_0443 1 None None None 119719190 Common - isopentenyl-diphosphate delta-isomerase, type 2 Tpen_0272 93 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 119720389 Common - Mg2+ transporter protein, CorA family protein Tpen_1484 100 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 119718954 Nonpathogen - hypothetical protein Tpen_0036 1 None None None 119720707 Nonpathogen - hypothetical protein Tpen_1804 9 COG2210 COG2210, Uncharacterized conserved protein Function unknown 119718992 Nonpathogen - hypothetical protein Tpen_0074 1 None None None 119720332 Common - plasma-membrane proton-efflux P-type ATPase Tpen_1427 232 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 119720121 Common - UDP-glucose/GDP-mannose dehydrogenase Tpen_1215 12 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 119719926 Nonpathogen - hypothetical protein Tpen_1018 1 None None None 119719382 Nonpathogen - hypothetical protein Tpen_0465 1 None None None 119720214 Nonpathogen - PaREP8 domain containing protein Tpen_1309 6 None None None 119720212 Nonpathogen - hypothetical protein Tpen_1306 3 None None None 119720172 Nonpathogen - hypothetical protein Tpen_1266 1 None None None 119719317 Nonpathogen - hypothetical protein Tpen_0400 1 None None None 119720132 Nonpathogen - hypothetical protein Tpen_1226 5 COG5625 COG5625, Predicted transcription regulator containing HTH domain Transcription 119719629 Nonpathogen - transcriptional regulator, HxlR family Tpen_0719 2 COG1733 COG1733, Predicted transcriptional regulators Transcription 119719900 Nonpathogen - HEPN domain protein Tpen_0992 5 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 119719266 Nonpathogen - Ribosomal protein S17e Tpen_0349 33 COG1383 RPS17A, Ribosomal protein S17E Translation, ribosomal structure and biogenesis 119719380 Nonpathogen - hypothetical protein Tpen_0463 28 COG1698 COG1698, Uncharacterized protein conserved in archaea Function unknown 119719569 Common - histidyl-tRNA synthetase Tpen_0659 249 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 119720548 Common - Sec-independent periplasmic protein translocase Tpen_1645 202 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 119719887 Nonpathogen - hypothetical protein Tpen_0979 1 None None None 119719587 Nonpathogen - hypothetical protein Tpen_0677 1 None None None 119720434 Common - ABC transporter related Tpen_1530 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 119719549 Nonpathogen - hypothetical protein Tpen_0638 1 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 119719908 Nonpathogen - hypothetical protein Tpen_1000 2 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 119719117 Common - TatD-related deoxyribonuclease Tpen_0199 229 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 119720087 Nonpathogen - hypothetical protein Tpen_1181 1 None None None 119718981 Nonpathogen - hypothetical protein Tpen_0063 3 None None None 119719527 Common - methionyl-tRNA synthetase Tpen_0615 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 119720482 Common - ABC transporter related Tpen_1579 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 119720305 Common - daunorubicin resistance ABC transporter ATPase subunit Tpen_1400 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 119720471 Nonpathogen - hypothetical protein Tpen_1568 3 COG5550 COG5550, Predicted aspartyl protease Posttranslational modification, protein turnover, chaperones 119720233 Common - ABC transporter related Tpen_1328 25 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 119719815 Common - extracellular solute-binding protein, family 3 Tpen_0906 191 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 119719598 Common - cytidyltransferase-related domain Tpen_0688 88 COG0615 TagD, Cytidylyltransferase Cell envelope biogenesis, outer membrane / Lipid metabolism 119720678 Common - ABC transporter related Tpen_1775 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 119720012 Common - ABC transporter related Tpen_1105 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 119719284 Nonpathogen - putative serine/threonine protein kinase Tpen_0367 14 COG2112 COG2112, Predicted Ser/Thr protein kinase Signal transduction mechanisms 119720137 Common - 3-dehydroquinate synthase Tpen_1231 53 COG0371 GldA, Glycerol dehydrogenase and related enzymes Energy production and conversion 119720271 Nonpathogen - hypothetical protein Tpen_1366 1 None None None 119720194 Nonpathogen - CRISPR-associated RAMP protein, SSO1426 family Tpen_1288 11 COG1337 COG1337, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 119719407 Common - ribosomal RNA adenine methylase transferase Tpen_0492 246 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 119719103 Common - NADH dehydrogenase (quinone) Tpen_0185 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 119720726 Common - major facilitator superfamily MFS_1 Tpen_1823 45 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 119719076 Common - glycosyl transferase, family 2 Tpen_0158 97 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 119720649 Common - glycosyl transferase, group 1 Tpen_1746 227 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 119720259 Common - CRISPR-associated helicase Cas3 Tpen_1354 57 COG1203 COG1203, Predicted helicases General function prediction only 119719996 Common - Glutamate--ammonia ligase Tpen_1089 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 119719481 Common leuS leucyl-tRNA synthetase Tpen_0568 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 119719421 Nonpathogen - hypothetical protein Tpen_0506 1 None None None 119719895 Common - partition protein, ParA-like Tpen_0987 185 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 119720356 Common - binding-protein-dependent transport systems inner membrane component Tpen_1451 141 COG3833 MalG, ABC-type maltose transport systems, permease component Carbohydrate transport and metabolism 119720027 Common - molybdopterin oxidoreductase Tpen_1121 182 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 119720442 Common - protein of unknown function DUF1611 Tpen_1538 38 COG3367 COG3367, Uncharacterized conserved protein Function unknown 119720100 Common - Methyltransferase type 11 Tpen_1194 149 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 119719017 Nonpathogen - hypothetical protein Tpen_0099 1 None None None 119719191 Common - protein of unknown function DUF52 Tpen_0273 67 COG1355 COG1355, Predicted dioxygenase General function prediction only 119720150 Nonpathogen - hypothetical protein Tpen_1244 1 None None None 119720260 Nonpathogen - hypothetical protein Tpen_1355 1 None None None 119719804 Common - transferase hexapeptide repeat containing protein Tpen_0895 216 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 119719158 Common - ribosomal protein S8 Tpen_0240 227 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 119720289 Common - ferredoxin Tpen_1384 71 COG3894 COG3894, Uncharacterized metal-binding protein General function prediction only 119719668 Nonpathogen - metallophosphoesterase Tpen_0758 7 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 119719756 Nonpathogen - methyltransferase small Tpen_0847 4 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 119719881 Common - iron dependent repressor Tpen_0973 98 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 119719967 Common - binding-protein-dependent transport systems inner membrane component Tpen_1059 216 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 119719825 Common - non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family Tpen_0916 224 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 119719291 Nonpathogen - Zinc finger, TFIIB-type domain protein Tpen_0374 34 COG1405 SUA7, Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB Transcription 119719025 Common - protein of unknown function DUF151 Tpen_0107 72 COG1259 COG1259, Uncharacterized conserved protein Function unknown 119719531 Nonpathogen - tRNA-splicing endonuclease subunit alpha Tpen_0619 33 COG1676 SEN2, tRNA splicing endonuclease Translation, ribosomal structure and biogenesis 119720541 Common - extracellular solute-binding protein, family 5 Tpen_1638 207 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 119719787 Nonpathogen rpl12p 50S ribosomal protein L12P Tpen_0878 33 COG2058 RPP1A, Ribosomal protein L12E/L44/L45/RPP1/RPP2 Translation, ribosomal structure and biogenesis 119719287 Nonpathogen - hypothetical protein Tpen_0370 22 COG2512 COG2512, Uncharacterized membrane-associated protein/domain Function unknown 119720175 Nonpathogen - glycoside hydrolase, family 57 Tpen_1269 1 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 119720523 Common - dihydrodipicolinate synthetase Tpen_1620 232 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 119719515 Common - CoA-binding domain protein Tpen_0602 170 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 119719505 Common - nickel-dependent hydrogenase, large subunit Tpen_0592 96 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 119719798 Nonpathogen - amino acid-binding ACT domain protein Tpen_0889 21 COG2150 COG2150, Predicted regulator of amino acid metabolism, contains ACT domain General function prediction only 119719478 Common argS arginyl-tRNA synthetase Tpen_0564 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 119720463 Common - ABC transporter related Tpen_1560 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 119718943 Nonpathogen - hypothetical protein Tpen_0025 1 None None None 119719270 Nonpathogen - putative nucleotide binding protein Tpen_0353 33 COG1491 COG1491, Predicted RNA-binding protein Translation, ribosomal structure and biogenesis 119719218 Nonpathogen - hypothetical protein Tpen_0300 2 None None None 119719829 Nonpathogen - hypothetical protein Tpen_0920 1 None None None 119720422 Nonpathogen - hypothetical protein Tpen_1517 4 None None None 119719309 Common - Proteasome endopeptidase complex Tpen_0392 43 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 119720478 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Tpen_1575 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 119720655 Nonpathogen - hypothetical protein Tpen_1752 1 None None None 119719121 Nonpathogen - hypothetical protein Tpen_0203 1 None None None 119719873 Nonpathogen - hypothetical protein Tpen_0965 1 None None None 119719177 Common rps13p 30S ribosomal protein S13P Tpen_0259 111 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 119719698 Nonpathogen - chemotaxis sensory transducer Tpen_0788 7 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 119719791 Nonpathogen - diphthamide biosynthesis protein Tpen_0882 34 COG1736 DPH2, Diphthamide synthase subunit DPH2 Translation, ribosomal structure and biogenesis 119720115 Common - inner-membrane translocator Tpen_1209 111 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 119720108 Common - Saccharopine dehydrogenase Tpen_1202 39 COG1748 LYS9, Saccharopine dehydrogenase and related proteins Amino acid transport and metabolism 119720717 Common - phosphoribosyltransferase Tpen_1814 73 COG1926 COG1926, Predicted phosphoribosyltransferases General function prediction only 119719659 Nonpathogen - hypothetical protein Tpen_0749 1 COG5373 COG5373, Predicted membrane protein Function unknown 119719022 Nonpathogen - hypothetical protein Tpen_0104 1 COG4742 COG4742, Predicted transcriptional regulator Transcription 119719846 Common - HI0933 family protein Tpen_0938 87 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 119720501 Nonpathogen - hypothetical protein Tpen_1598 1 None None None 119719326 Nonpathogen - translation initiation factor IF-5A Tpen_0409 34 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 119719990 Common - NADH dehydrogenase subunit I Tpen_1083 190 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 119719366 Nonpathogen - Ribosomal protein S27a Tpen_0449 12 COG1998 RPS31, Ribosomal protein S27AE Translation, ribosomal structure and biogenesis 119720613 Nonpathogen - hypothetical protein Tpen_1710 1 None None None 119720208 Nonpathogen - hypothetical protein Tpen_1302 2 None None None 119720223 Nonpathogen - hypothetical protein Tpen_1318 2 None None None 119719038 Common - spermidine synthase Tpen_0120 128 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 119719409 Common - Fmu (Sun) domain protein Tpen_0494 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 119720342 Nonpathogen - hypothetical protein Tpen_1437 2 None None None 119720728 Common - signal peptide peptidase SppA, 36K type Tpen_1825 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 119719397 Nonpathogen - hypothetical protein Tpen_0480 1 None None None 119718927 Common - transglutaminase domain protein Tpen_0009 39 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 119719310 Common - DNA polymerase II Tpen_0393 68 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 119720035 Common - thioredoxin Tpen_1129 234 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 119719678 Common - Fmu (Sun) domain protein Tpen_0768 194 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 119720314 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Tpen_1409 165 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion