Mesorhizobium sp. BNC1 plasmid 1, complete sequence NC_008242 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 110346938 Common - periplasmic sensor signal transduction histidine kinase Meso_4124 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 110347076 Common - transcriptional regulator, Crp/Fnr family Meso_4277 164 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 110347085 Common - hypothetical protein Meso_4286 20 None None None 110347080 Common - protein of unknown function DUF59 Meso_4281 138 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 110347204 Common - type III restriction enzyme, res subunit Meso_4408 70 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 110346967 Common - protein of unknown function DUF1173 Meso_4154 16 None None None 110346995 Common - succinoglycan biosynthesis protein exoI-like Meso_4182 5 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 110347215 Common - cytochrome c, class II Meso_4420 10 COG3909 COG3909, Cytochrome c556 Energy production and conversion 110346945 Common - electron transport protein SCO1/SenC Meso_4131 103 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 110347132 Common - putative TraC conjugal transfer protein Meso_4333 6 None None None 110347099 Common - hemerythrin-like metal-binding protein Meso_4300 50 COG2703 COG2703, Hemerythrin Inorganic ion transport and metabolism 110347165 Common - Pyridoxal-5'-phosphate-dependent enzyme, beta subunit Meso_4366 225 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 110347055 Common - spermidine/putrescine ABC transporter ATPase subunit Meso_4252 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 110347139 Common - Conjugal transfer protein TrbG/VirB9/CagX Meso_4340 42 COG3504 VirB9, Type IV secretory pathway, VirB9 components Intracellular trafficking and secretion 110346971 Common - hypothetical protein Meso_4158 8 None None None 110347230 Common - ferric uptake regulator, Fur family Meso_4436 183 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 110346978 Common - hypothetical protein Meso_4165 3 None None None 110347042 Nonpathogen - hypothetical protein Meso_4237 1 None None None 110347183 Common - heavy metal efflux pump, CzcA family Meso_4386 178 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 110347100 Nonpathogen - hypothetical protein Meso_4301 2 None None None 110346923 Common - DSBA oxidoreductase Meso_4108 98 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 110347030 Common - hypothetical protein Meso_4225 21 None None None 110347094 Common - Putative lipid carrier protein-like Meso_4295 13 COG3154 COG3154, Putative lipid carrier protein Lipid metabolism 110347061 Common - transcriptional regulator, GntR family Meso_4258 38 COG1802 GntR, Transcriptional regulators Transcription 110347031 Common - transcriptional modulator of MazE/toxin, MazF Meso_4226 25 COG2337 MazF, Growth inhibitor Signal transduction mechanisms 110347155 Common - replication protein C Meso_4356 18 COG1414 IclR, Transcriptional regulator Transcription 110347107 Common - transposase, IS4 Meso_4308 17 None None None 110346959 Common - ParB-like nuclease Meso_4146 133 COG1475 Spo0J, Predicted transcriptional regulators Transcription 110347144 Common - type IV secretion system Meso_4345 22 None None None 110346933 Common - transcriptional regulator, MerR family Meso_4119 139 COG0789 SoxR, Predicted transcriptional regulators Transcription 110346981 Common - hypothetical protein Meso_4168 7 None None None 110347012 Common - major intrinsic protein Meso_4200 106 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 110346950 Common - hypothetical protein Meso_4137 10 None None None 110347019 Common - fatty acid alpha hydroxylase, cytochrome P450 Meso_4213 13 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 110347223 Common - polar amino acid ABC transporter, inner membrane subunit Meso_4428 173 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 110347121 Common - Domain of unknown function DUF1738 Meso_4322 48 COG4227 COG4227, Antirestriction protein DNA replication, recombination, and repair 110347083 Nonpathogen - hypothetical protein Meso_4284 1 None None None 110346989 Common - Lytic transglycosylase, catalytic Meso_4176 168 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 110347111 Common - protein of unknown function DUF1419 Meso_4312 8 None None None 110347208 Nonpathogen - hypothetical protein Meso_4413 2 None None None 110347153 Common - Cobyrinic acid a,c-diamide synthase Meso_4354 217 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 110347206 Common - Competence protein-like Meso_4410 8 COG4469 CoiA, Competence protein General function prediction only 110347087 Common - hypothetical protein Meso_4288 32 COG0348 NapH, Polyferredoxin Energy production and conversion 110347096 Common - peptidase U32 Meso_4297 46 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 110347161 Common - transcriptional regulator, GntR family Meso_4362 150 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 110347149 Common - hypothetical protein Meso_4350 9 None None None 110347172 Common - ABC transporter related Meso_4373 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 110347158 Common - hypothetical protein Meso_4359 5 None None None 110347193 Nonpathogen - hypothetical protein Meso_4397 5 None None None 110347079 Common - SEC-independent protein translocase protein TatC Meso_4280 44 COG2346 COG2346, Truncated hemoglobins General function prediction only 110347217 Common - multicopper oxidase, type 3 Meso_4422 109 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 110347219 Common - cation efflux protein Meso_4424 133 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 110347003 Common - Cobyrinic acid a,c-diamide synthase Meso_4190 211 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 110346947 Common - DSBA oxidoreductase Meso_4133 61 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 110347126 Nonpathogen - hypothetical protein Meso_4327 1 None None None 110346926 Common - ErfK/YbiS/YcfS/YnhG Meso_4112 72 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 110346965 Nonpathogen - hypothetical protein Meso_4152 2 None None None 110347027 Common - Integrase, catalytic region Meso_4222 59 None None None 110347063 Common - pyridine nucleotide-disulphide oxidoreductase dimerisation region Meso_4261 224 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 110347000 Common - methyltransferase FkbM family Meso_4187 10 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 110347109 Nonpathogen - hypothetical protein Meso_4310 7 None None None 110346924 Common - pseudoazurin Meso_4110 24 COG3794 PetE, Plastocyanin Energy production and conversion 110347185 Common - multicopper oxidase, type 3 Meso_4388 132 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 110347074 Common - NnrS Meso_4275 56 COG3213 NnrS, Uncharacterized protein involved in response to NO Inorganic ion transport and metabolism 110347163 Common - FAD dependent oxidoreductase Meso_4364 121 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 110347102 Nonpathogen - uncharacterized protein SCO1/SenC/PrrC Meso_4303 2 None None None 110347123 Nonpathogen - Rv0623-like transcription factor Meso_4324 3 COG4423 COG4423, Uncharacterized protein conserved in bacteria Function unknown 110347048 Nonpathogen - hypothetical protein Meso_4243 1 None None None 110347220 Nonpathogen - hypothetical protein Meso_4425 2 None None None 110346952 Common - ChrB domain protein Meso_4139 21 None None None 110346935 Nonpathogen - hypothetical protein Meso_4121 1 None None None 110347142 Common - TrbL/VirB6 plasmid conjugal transfer protein Meso_4343 31 COG3704 VirB6, Type IV secretory pathway, VirB6 components Intracellular trafficking and secretion 110347225 Common - extracellular solute-binding protein, family 3 Meso_4430 103 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 110346983 Common - type II secretion system protein E Meso_4170 223 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 110346996 Common - nuclease (SNase-like) Meso_4183 13 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 110346972 Common - protein of unknown function DUF736 Meso_4159 23 COG5489 COG5489, Uncharacterized conserved protein Function unknown 110347021 Common - Coenzyme F390 synthetase-like Meso_4216 79 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 110347212 Common - protein of unknown function DUF1612 Meso_4417 8 None None None 110347051 Common - hypothetical protein Meso_4248 4 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 110346949 Nonpathogen - hypothetical protein Meso_4135 1 None None None 110347156 Common - Resolvase-like Meso_4357 128 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 110347098 Common - isopentenyl-diphosphate delta-isomerase, type 1 Meso_4299 53 COG1443 Idi, Isopentenyldiphosphate isomerase Lipid metabolism 110347184 Nonpathogen - hypothetical protein Meso_4387 1 None None None 110347233 Common - transglutaminase-like cysteine peptidase, BTLCP Meso_4440 23 COG3672 COG3672, Predicted periplasmic protein Function unknown 110347072 Common - nitrite reductase, copper-containing Meso_4273 60 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 110346985 Common - Conjugal transfer protein TrbG/VirB9/CagX Meso_4172 56 COG3504 VirB9, Type IV secretory pathway, VirB9 components Intracellular trafficking and secretion 110347209 Common - lipoprotein signal peptidase Meso_4414 189 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 110347200 Common - DNA polymerase, beta-like region Meso_4404 13 COG1746 CCA1, tRNA nucleotidyltransferase (CCA-adding enzyme) Translation, ribosomal structure and biogenesis 110347151 Common - replication protein C Meso_4352 17 None None None 110347082 Common - hypothetical protein Meso_4283 26 None None None 110347198 Common - hypothetical protein Meso_4402 7 None None None 110347226 Common - Cys/Met metabolism pyridoxal-phosphate-dependent enzymes Meso_4431 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 110347128 Common - protein of unknown function DUF1173 Meso_4329 16 None None None 110347141 Common - putative type IV secretion system protein VirB7 Meso_4342 8 None None None 110347221 Common - transcriptional regulator, MerR family Meso_4426 128 COG0789 SoxR, Predicted transcriptional regulators Transcription 110346954 Common - hypothetical protein Meso_4141 3 None None None 110346937 Common - two component transcriptional regulator, winged helix family Meso_4123 218 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 110347125 Common - protein of unknown function DUF736 Meso_4326 26 COG5489 COG5489, Uncharacterized conserved protein Function unknown 110347016 Common - cytochrome c biogenesis protein, transmembrane region Meso_4210 92 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 110347046 Common - AAA ATPase, central region Meso_4241 78 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 110347104 Common - TniB Meso_4305 33 None None None 110347170 Common - polar amino acid ABC transporter, inner membrane subunit Meso_4371 172 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 110347114 Common - transposase IS116/IS110/IS902 Meso_4315 36 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 110347191 Common - hypothetical protein Meso_4395 8 None None None 110347020 Common - Co/Zn/Cd efflux system component Meso_4214 29 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 110347186 Common - protein of unknown function DUF411 Meso_4389 64 COG3019 COG3019, Predicted metal-binding protein General function prediction only 110347038 Nonpathogen - hypothetical protein Meso_4233 1 None None None 110347135 Common - Zeta toxin Meso_4336 14 None None None 110347179 Nonpathogen - hypothetical protein Meso_4382 3 None None None 110347169 Common - extracellular solute-binding protein, family 3 Meso_4370 151 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 110347009 Common - putative transcriptional regulator Meso_4197 140 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 110347043 Common - transcriptional regulator, XRE family Meso_4238 4 COG1396 HipB, Predicted transcriptional regulators Transcription 110347065 Common - glycine dehydrogenase Meso_4266 172 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 110346929 Common - ErfK/YbiS/YcfS/YnhG Meso_4115 39 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 110347060 Common - large subunit of N,N-dimethylformamidase Meso_4257 16 None None None 110347002 Common - periplasmic sensor signal transduction histidine kinase Meso_4189 83 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 110347023 Nonpathogen - hypothetical protein Meso_4218 1 None None None 110347130 Common - TRAG protein Meso_4331 60 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 110347026 Common - TniB Meso_4221 33 None None None 110347137 Common - type II secretion system protein E Meso_4338 155 COG0630 VirB11, Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis Cell motility and secretion / Intracellular trafficking and secretion 110347214 Nonpathogen - hypothetical protein Meso_4419 1 None None None 110347154 Common - parB-like partition proteins Meso_4355 117 COG1475 Spo0J, Predicted transcriptional regulators Transcription 110347106 Common - bifunctional deaminase-reductase-like Meso_4307 44 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 110347084 Common - conserved hypothetical membrane antigen Meso_4285 24 COG3470 Tpd, Uncharacterized protein probably involved in high-affinity Fe2+ transport Inorganic ion transport and metabolism 110347197 Nonpathogen - hypothetical protein Meso_4401 4 None None None 110346998 Nonpathogen - hypothetical protein Meso_4185 1 None None None 110346974 Common - WGR Meso_4161 17 COG3831 COG3831, Uncharacterized conserved protein Function unknown 110346991 Common - type IV secretory pathway, VirB3-like Meso_4178 14 COG3702 VirB3, Type IV secretory pathway, VirB3 components Intracellular trafficking and secretion 110346968 Common - putative methylase/helicase Meso_4155 24 None None None 110347006 Common - hypothetical protein Meso_4194 9 None None None 110346943 Common - heavy metal translocating P-type ATPase Meso_4129 231 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 110347089 Nonpathogen - hypothetical protein Meso_4290 3 None None None 110347057 Common - binding-protein-dependent transport systems inner membrane component Meso_4254 206 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 110347202 Common - AAA ATPase, central region Meso_4406 54 COG1223 COG1223, Predicted ATPase (AAA+ superfamily) General function prediction only 110346961 Common - hypothetical protein Meso_4148 4 None None None 110346918 Common - cytochrome c biogenesis protein, transmembrane region Meso_4103 166 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 110347177 Common - Resolvase-like Meso_4379 122 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 110347231 Common - UspA Meso_4438 35 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 110347116 Common - ParB-like nuclease Meso_4317 112 COG1475 Spo0J, Predicted transcriptional regulators Transcription 110346920 Common - Isoprenylcysteine carboxyl methyltransferase Meso_4105 40 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 110347033 Common - protein of unknown function DUF736 Meso_4228 24 COG5489 COG5489, Uncharacterized conserved protein Function unknown 110346977 Common - hypothetical protein Meso_4164 32 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 110346987 Common - TrbL/VirB6 plasmid conjugal transfer protein Meso_4174 23 COG3704 VirB6, Type IV secretory pathway, VirB6 components Intracellular trafficking and secretion 110347120 Common - hypothetical protein Meso_4321 8 None None None 110347018 Common - heavy metal translocating P-type ATPase Meso_4212 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 110346951 Common - Domain of unknown function DUF1738 Meso_4138 48 COG4227 COG4227, Antirestriction protein DNA replication, recombination, and repair 110346992 Common - VIRB2 type IV secretion Meso_4179 17 COG3838 VirB2, Type IV secretory pathway, VirB2 components (pilins) Intracellular trafficking and secretion 110346939 Common - HflK protein Meso_4125 148 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 110346930 Common - protein of unknown function DUF949 Meso_4116 46 COG3034 COG3034, Uncharacterized protein conserved in bacteria Function unknown 110347228 Common - hypothetical protein Meso_4433 8 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 110346956 Common - hypothetical protein Meso_4143 7 None None None 110347146 Common - type IV secretory pathway, VirB3-like Meso_4347 13 COG3702 VirB3, Type IV secretory pathway, VirB3 components Intracellular trafficking and secretion 110347077 Nonpathogen - hypothetical protein Meso_4278 7 None None None 110347041 Nonpathogen - hypothetical protein Meso_4236 5 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 110347008 Common - protein of unknown function DUF1403 Meso_4196 9 None None None 110347067 Common - glycine cleavage system T protein Meso_4268 178 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 110347118 Common - hypothetical protein Meso_4319 8 None None None 110347050 Nonpathogen - hypothetical protein Meso_4247 1 None None None 110347036 Common - phage integrase Meso_4231 16 None None None 110347167 Common - ornithine cyclodeaminase/mu-crystallin Meso_4368 88 COG2423 COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog Amino acid transport and metabolism 110347180 Common - TniB Meso_4383 33 None None None 110347143 Common - hypothetical protein Meso_4344 4 None None None 110347195 Nonpathogen - hypothetical protein Meso_4399 2 None None None 110347040 Nonpathogen - hypothetical protein Meso_4235 1 None None None 110347073 Nonpathogen - hypothetical protein Meso_4274 1 None None None 110347164 Common - Endoribonuclease L-PSP Meso_4365 186 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 110347175 Common - transposase IS3/IS911 Meso_4376 35 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 110346922 Common - hypothetical protein Meso_4107 33 COG3809 COG3809, Uncharacterized protein conserved in bacteria Function unknown 110347216 Common - putative metal cation transporter Meso_4421 9 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 110347039 Common - histone-like DNA-binding protein Meso_4234 173 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 110347034 Common - phage integrase-like SAM-like Meso_4229 13 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 110346980 Common - hypothetical protein Meso_4167 2 None None None 110347229 Common - heavy metal translocating P-type ATPase Meso_4435 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 110346988 Common - conjugal transfer protein Meso_4175 4 None None None 110346958 Common - hypothetical protein Meso_4145 11 None None None 110347011 Common - protein tyrosine phosphatase Meso_4199 113 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 110346953 Common - putative transporter Meso_4140 58 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 110347122 Common - hypothetical protein Meso_4323 7 COG1641 COG1641, Uncharacterized conserved protein Function unknown 110347005 Common - replication protein C Meso_4192 17 None None None 110347131 Common - Conjugal transfer TraD Meso_4332 7 None None None 110347070 Common - transcriptional regulator, LysR family Meso_4271 184 COG0583 LysR, Transcriptional regulator Transcription 110347203 Nonpathogen - hypothetical protein Meso_4407 9 None None None 110347086 Common - iron permease FTR1 Meso_4287 55 COG0672 FTR1, High-affinity Fe2+/Pb2+ permease Inorganic ion transport and metabolism 110346966 Nonpathogen - hypothetical protein Meso_4153 1 None None None 110346925 Common - potassium transporter (trk family) Meso_4111 71 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 110346994 Common - hypothetical protein Meso_4181 3 None None None 110346944 Common - protein of unknown function DUF461 Meso_4130 80 COG2847 COG2847, Uncharacterized protein conserved in bacteria Function unknown 110347192 Common - protein of unknown function DUF1612 Meso_4396 8 None None None 110347062 Common - hypothetical protein Meso_4260 7 COG0403 GcvP, Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain Amino acid transport and metabolism 110347091 Common - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Meso_4292 153 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 110346979 Common - hypothetical protein Meso_4166 9 None None None 110347075 Common - pseudoazurin Meso_4276 25 COG3794 PetE, Plastocyanin Energy production and conversion 110347028 Common - putative methylase/helicase Meso_4223 21 None None None 110347110 Common - hypothetical protein Meso_4311 10 None None None 110347101 Common - cytochrome b/b6-like Meso_4302 146 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 110347138 Common - conjugation TrbI-like protein Meso_4339 59 COG2948 VirB10, Type IV secretory pathway, VirB10 components Intracellular trafficking and secretion 110347108 Common - hypothetical protein Meso_4309 6 None None None 110347053 Common - aminotransferase class-III Meso_4250 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 110346955 Common - hypothetical protein Meso_4142 14 None None None 110347103 Nonpathogen - hypothetical protein Meso_4304 3 None None None 110347182 Common - efflux transporter, RND family, MFP subunit Meso_4385 144 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 110347071 Common - protein of unknown function DUF323 Meso_4272 67 COG1262 COG1262, Uncharacterized conserved protein Function unknown 110346932 Nonpathogen - hypothetical protein Meso_4118 2 COG2847 COG2847, Uncharacterized protein conserved in bacteria Function unknown 110347162 Common - Endoribonuclease L-PSP Meso_4363 105 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 110347010 Common - transcriptional regulator, ArsR family Meso_4198 63 COG4189 COG4189, Predicted transcriptional regulator Transcription 110347064 Common - L-serine dehydratase 1 Meso_4265 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 110347013 Common - arsenate reductase Meso_4201 113 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 110347224 Common - polar amino acid ABC transporter, inner membrane subunit Meso_4429 171 COG4597 BatB, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 110347124 Common - PilT protein-like Meso_4325 18 COG3742 COG3742, Uncharacterized protein conserved in bacteria Function unknown 110347032 Common - hypothetical protein Meso_4227 6 None None None 110347148 Common - Lytic transglycosylase, catalytic Meso_4349 22 None None None 110347047 Common - TRAG protein Meso_4242 60 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 110347088 Common - NnrS Meso_4289 54 COG3213 NnrS, Uncharacterized protein involved in response to NO Inorganic ion transport and metabolism 110346982 Common - TRAG protein Meso_4169 80 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 110346927 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Meso_4113 146 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 110346963 Common - hypothetical protein Meso_4150 10 None None None 110346997 Common - hypothetical protein Meso_4184 9 None None None 110347152 Common - hypothetical protein Meso_4353 9 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 110347004 Common - parB-like partition proteins Meso_4191 107 COG1475 Spo0J, Predicted transcriptional regulators Transcription 110347205 Common - hypothetical protein Meso_4409 21 COG3673 COG3673, Uncharacterized conserved protein Function unknown 110347207 Nonpathogen - hypothetical protein Meso_4412 3 COG2842 COG2842, Uncharacterized ATPase, putative transposase General function prediction only 110347112 Common - hypothetical protein Meso_4313 6 None None None 110347160 Common - hypothetical protein Meso_4361 5 None None None 110347211 Nonpathogen - hypothetical protein Meso_4416 3 None None None 110346970 Common - hypothetical protein Meso_4157 21 None None None 110347069 Common - glycine hydroxymethyltransferase Meso_4270 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 110347022 Common - transcriptional regulator, MerR family Meso_4217 137 COG0789 SoxR, Predicted transcriptional regulators Transcription 110347056 Common - binding-protein-dependent transport systems inner membrane component Meso_4253 215 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 110346946 Common - Disulphide bond formation protein DsbB Meso_4132 21 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 110346941 Common - HflK protein Meso_4127 117 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 110347133 Common - MobA/MobL protein Meso_4334 95 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 110346964 Nonpathogen - hypothetical protein Meso_4151 4 None None None 110347188 Common - hypothetical protein Meso_4392 17 None None None 110347093 Nonpathogen - hypothetical protein Meso_4294 2 None None None 110347218 Common - manganese transport regulator MntR Meso_4423 90 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 110347140 Common - VirB8 Meso_4341 36 COG3736 VirB8, Type IV secretory pathway, component VirB8 Intracellular trafficking and secretion 110347129 Nonpathogen - hypothetical protein Meso_4330 2 None None None 110346984 Common - conjugation TrbI-like protein Meso_4171 59 COG2948 VirB10, Type IV secretory pathway, VirB10 components Intracellular trafficking and secretion 110347066 Common - glycine cleavage system H protein Meso_4267 186 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 110347105 Common - Integrase, catalytic region Meso_4306 59 None None None 110346957 Common - phage integrase-like SAM-like Meso_4144 11 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 110347190 Common - Integrase, catalytic region Meso_4394 48 None None None 110347113 Common - Adenine-specific DNA methylase-like Meso_4314 16 COG0827 COG0827, Adenine-specific DNA methylase DNA replication, recombination, and repair 110347173 Common - transcriptional regulator, LysR family Meso_4374 187 COG0583 LysR, Transcriptional regulator Transcription 110347045 Nonpathogen - hypothetical protein Meso_4240 1 None None None 110347015 Common nadE NAD synthetase Meso_4206 178 COG0171 NadE, NAD synthase Coenzyme metabolism 110347234 Common - apolipoprotein N-acyltransferase Meso_4441 159 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 110347014 Common - transcriptional regulator, ArsR family Meso_4202 65 COG0640 ArsR, Predicted transcriptional regulators Transcription 110347001 Common - hypothetical protein Meso_4188 6 COG3915 COG3915, Uncharacterized protein conserved in bacteria Function unknown 110347168 Common - transcriptional regulator, LysR family Meso_4369 156 COG0583 LysR, Transcriptional regulator Transcription 110347178 Common - hypothetical protein Meso_4380 35 COG3970 COG3970, Fumarylacetoacetate (FAA) hydrolase family protein General function prediction only 110347037 Nonpathogen - hypothetical protein Meso_4232 1 None None None 110347189 Common - TniB Meso_4393 25 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 110346928 Common - DSBA oxidoreductase Meso_4114 94 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 110346934 Common - manganese transport protein MntH Meso_4120 102 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 110346940 Common - HflC protein Meso_4126 135 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 110346973 Nonpathogen - hypothetical protein Meso_4160 2 None None None 110347095 Common - peptidase U32 Meso_4296 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 110346999 Common - response regulator receiver protein Meso_4186 10 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 110347196 Nonpathogen - hypothetical protein Meso_4400 4 COG2856 COG2856, Predicted Zn peptidase Amino acid transport and metabolism 110346948 Common - protein of unknown function DUF1624 Meso_4134 32 COG3503 COG3503, Predicted membrane protein Function unknown 110346969 Common - hypothetical protein Meso_4156 37 COG4643 COG4643, Uncharacterized protein conserved in bacteria Function unknown 110347134 Nonpathogen - hypothetical protein Meso_4335 1 None None None 110347029 Common - hypothetical protein Meso_4224 42 COG4643 COG4643, Uncharacterized protein conserved in bacteria Function unknown 110347024 Nonpathogen - hypothetical protein Meso_4219 8 None None None 110347115 Common - Methyltransferase type 11 Meso_4316 39 COG4646 COG4646, DNA methylase Transcription / DNA replication, recombination, and repair 110347159 Common - transposase Meso_4360 47 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 110347147 Common - VIRB2 type IV secretion Meso_4348 10 COG3838 VirB2, Type IV secretory pathway, VirB2 components (pilins) Intracellular trafficking and secretion 110347090 Common - hypothetical protein Meso_4291 8 COG4309 COG4309, Uncharacterized conserved protein Function unknown 110347150 Common - hypothetical protein Meso_4351 6 None None None 110347176 Common - transposase Tn3 Meso_4378 56 COG4644 COG4644, Transposase and inactivated derivatives, TnpA family DNA replication, recombination, and repair 110347127 Common - WGR Meso_4328 12 COG3831 COG3831, Uncharacterized conserved protein Function unknown 110347213 Nonpathogen - hypothetical protein Meso_4418 1 None None None 110346962 Common - hypothetical protein Meso_4149 8 None None None 110347054 Common - peptidase S58, DmpA Meso_4251 37 COG3191 DmpA, L-aminopeptidase/D-esterase Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 110346919 Common - cell wall hydrolase, SleB Meso_4104 47 COG3773 SleB, Cell wall hydrolyses involved in spore germination Cell envelope biogenesis, outer membrane 110347227 Common - transcriptional regulator, LysR family Meso_4432 168 COG0583 LysR, Transcriptional regulator Transcription 110346976 Common - hypothetical protein Meso_4163 3 None None None 110347017 Common - lipoprotein signal peptidase Meso_4211 156 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 110346931 Common - transglutaminase-like cysteine peptidase, BTLCP Meso_4117 16 COG3672 COG3672, Predicted periplasmic protein Function unknown 110347058 Common - extracellular solute-binding protein, family 1 Meso_4255 127 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 110347171 Common - polar amino acid ABC transporter, inner membrane subunit Meso_4372 173 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 110346993 Common - Lytic transglycosylase, catalytic Meso_4180 127 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 110347222 Common - ABC transporter related Meso_4427 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 110347199 Nonpathogen - transcriptional regulator Meso_4403 3 None None None 110347187 Nonpathogen - hypothetical protein Meso_4391 1 None None None 110346986 Common - VirB8 Meso_4173 37 COG3736 VirB8, Type IV secretory pathway, component VirB8 Intracellular trafficking and secretion 110347049 Common - MobA/MobL protein Meso_4244 78 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 110347157 Common - phage integrase Meso_4358 56 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 110347166 Common - alanine racemase-like Meso_4367 67 COG3616 COG3616, Predicted amino acid aldolase or racemase Amino acid transport and metabolism 110347145 Common - type IV secretion/conjugal transfer ATPase, VirB4 family Meso_4346 64 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 110347092 Common - UbiD family decarboxylases Meso_4293 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 110347181 Common - Integrase, catalytic region Meso_4384 59 None None None 110347119 Common - hypothetical protein Meso_4320 6 None None None 110347078 Common - transcriptional regulator, BadM/Rrf2 family Meso_4279 144 COG1959 COG1959, Predicted transcriptional regulator Transcription 110347068 Common - dihydrolipoamide dehydrogenase Meso_4269 246 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 110347035 Common - hypothetical protein Meso_4230 13 None None None 110347044 Nonpathogen - hypothetical protein Meso_4239 1 None None None 110347210 Common - ErfK/YbiS/YcfS/YnhG Meso_4415 83 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 110347174 Common - Integrase, catalytic region Meso_4375 151 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 110347136 Nonpathogen - hypothetical protein Meso_4337 2 None None None 110347052 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Meso_4249 218 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 110347025 Nonpathogen - hypothetical protein Meso_4220 3 None None None 110347007 Common - phage integrase Meso_4195 52 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 110346942 Common - hypothetical protein Meso_4128 70 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 110346990 Common - type IV secretion/conjugal transfer ATPase, VirB4 family Meso_4177 60 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 110347059 Common - hypothetical protein Meso_4256 4 None None None 110346975 Common - hypothetical protein Meso_4162 4 None None None 110347081 Common - hypothetical protein Meso_4282 13 None None None 110346936 Common - Endonuclease/exonuclease/phosphatase Meso_4122 24 COG3021 COG3021, Uncharacterized protein conserved in bacteria Function unknown 110347097 Common - coproporphyrinogen III oxidase Meso_4298 203 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 110347232 Common - lipoprotein signal peptidase Meso_4439 88 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 110346960 Common - hypothetical protein Meso_4147 8 None None None 110347194 Common - hypothetical protein Meso_4398 10 None None None 110347201 Nonpathogen - hypothetical protein Meso_4405 4 None None None 110347117 Common - hypothetical protein Meso_4318 8 None None None 110346921 Common - protein of unknown function DUF204 Meso_4106 62 COG1971 COG1971, Predicted membrane protein Function unknown