Thiomicrospira crunogena XCL-2, complete genome NC_007520 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 78485150 Common - acetyl-CoA carboxylase, carboxyl transferase, beta subunit Tcr_0805 220 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 78486393 Common - Ham1-like protein Tcr_2054 235 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 78484693 Common - N-acetyl-gamma-glutamyl-phosphate reductase Tcr_0348 216 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 78485039 Nonpathogen - hypothetical protein Tcr_0694 1 None None None 78486023 Common - hypothetical protein Tcr_1682 9 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 78484903 Common - hypothetical protein Tcr_0558 147 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 78484881 Common - glutamine synthetase, type I Tcr_0536 226 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 78485351 Common - hypothetical protein Tcr_1007 8 None None None 78484679 Common - type I site-specific deoxyribonuclease, HsdR family Tcr_0334 135 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 78486516 Common - response regulator receiver (CheY-like) modulated metal dependent phosphohydrolase Tcr_2179 224 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 78484427 Common - DNA/RNA non-specific endonuclease Tcr_0081 45 COG1864 NUC1, DNA/RNA endonuclease G, NUC1 Nucleotide transport and metabolism 78484380 Common - Binding-protein-dependent transport systems inner membrane component Tcr_0034 185 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 78485380 Common - electron transport complex, RnfABCDGE type, A subunit Tcr_1036 76 COG4657 RnfA, Predicted NADH:ubiquinone oxidoreductase, subunit RnfA Energy production and conversion 78485386 Common - putative ATP-binding protein Tcr_1042 229 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 78486030 Common - NAD-dependent epimerase/dehydratase Tcr_1689 221 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 78486285 Common - 3-hydroxydecanoyl-(acyl carrier protein) dehydratase Tcr_1946 81 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 78485635 Common - succinyl-diaminopimelate desuccinylase Tcr_1291 208 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 78485773 Common - flagellar motor switch protein FliM Tcr_1432 113 COG1868 FliM, Flagellar motor switch protein Cell motility and secretion 78485025 Common - Peptidase S49 Tcr_0680 170 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 118139509 Nonpathogen - hypothetical protein Tcr_0022 6 None None None 78486456 Common - hypothetical protein Tcr_2118 16 None None None 78484969 Common - Pyrrolo-quinoline quinone Tcr_0624 114 COG1520 COG1520, FOG: WD40-like repeat Function unknown 78486438 Common - hypothetical protein Tcr_2100 24 None None None 78484901 Common - hypothetical protein Tcr_0556 11 None None None 78485358 Common - cation diffusion facilitator family transporter Tcr_1014 208 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 78484409 Common - putative monovalent cation/H+ antiporter subunit A Tcr_0063 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 78484660 Common secY preprotein translocase subunit SecY Tcr_0315 234 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 78484961 Common - serine O-acetyltransferase Tcr_0616 205 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 78485783 Common - flagellar M-ring protein FliF Tcr_1442 127 COG1766 FliF, Flagellar biosynthesis/type III secretory pathway lipoprotein Cell motility and secretion / Intracellular trafficking and secretion 78486537 Common - methylated-DNA--protein-cysteine methyltransferase Tcr_2200 215 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 78486313 Common - Sec-independent protein translocase TatC Tcr_1974 202 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 78485319 Nonpathogen - Protein of unknown function DUF1239 Tcr_0975 1 None None None 78485304 Common - 3-deoxy-D-manno-octulosonate cytidylyltransferase Tcr_0960 140 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 78485487 Common - diguanylate cyclase (GGDEF domain) Tcr_1143 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 78484620 Common - OsmC-like protein Tcr_0275 90 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 78484610 Common - phosphoglycolate phosphatase Tcr_0265 204 COG0546 Gph, Predicted phosphatases General function prediction only 78485497 Common - Nitrate transporter system, periplasmic component Tcr_1153 78 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 78484670 Common - Protein of unknown function DUF541 Tcr_0325 18 COG3471 COG3471, Predicted periplasmic/secreted protein Function unknown 78486133 Common - Allophanate hydrolase subunit 2 Tcr_1792 233 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 78484791 Common - Protein-disulfide reductase Tcr_0446 151 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 78485235 Common - aspartyl-tRNA synthetase Tcr_0890 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 78485742 Common - 3,4-dihydroxy-2-butanone 4-phosphate synthase Tcr_1398 231 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 78484918 Common - Dihydrofolate reductase Tcr_0573 147 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 78484627 Common - SecE subunit of protein translocation complex Tcr_0282 72 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 78484899 Common - ATP-dependent helicase HrpB Tcr_0554 131 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 78484745 Common - 2-polyprenylphenol 6-hydroxylase Tcr_0400 184 COG0661 AarF, Predicted unusual protein kinase General function prediction only 78485610 Nonpathogen - hypothetical protein Tcr_1266 5 None None None 78485631 Common - UTP-GlnB (protein PII) uridylyltransferase, GlnD Tcr_1287 125 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 78485925 Common - MscS Mechanosensitive ion channel Tcr_1584 198 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 78484669 Common - excinuclease ABC, A subunit Tcr_0324 240 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 78485969 Common - glutamyl-tRNA(Gln) amidotransferase, A subunit Tcr_1628 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 78485606 Common - CTP synthetase Tcr_1262 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 78484429 Common - SmtA protein Tcr_0084 46 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 78486003 Common - phenylalanyl-tRNA synthetase, beta subunit Tcr_1662 248 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 78486423 Common - Phosphonate metabolism PhnJ Tcr_2085 45 COG3627 PhnJ, Uncharacterized enzyme of phosphonate metabolism Inorganic ion transport and metabolism 78484997 Common - thiol:disulfide interchange protein DsbC Tcr_0652 67 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 78485681 Common - choline/carnitine/betaine transport Tcr_1337 96 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 78485803 Common - NAD-dependent epimerase/dehydratase Tcr_1462 235 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 78485480 Common - ABC-2 Tcr_1136 123 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 78484871 Common - membrane protein-like Tcr_0526 18 COG3671 COG3671, Predicted membrane protein Function unknown 78485252 Common - hypothetical protein Tcr_0907 6 None None None 78485798 Common - UDP-N-acetylglucosamine 2-epimerase Tcr_1457 80 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 118139520 Common - Carbonate dehydratase Tcr_1545 52 COG3338 Cah, Carbonic anhydrase Inorganic ion transport and metabolism 78484542 Common - diguanylate cyclase (GGDEF domain) with PAS/PAC sensor Tcr_0197 189 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 78484886 Common - two component transcriptional regulator, winged helix family Tcr_0541 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 78486054 Common - DNA polymerase III subunit epsilon Tcr_1713 26 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 78485703 Common - alanine racemase Tcr_1359 200 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 78484364 Common - Peptidase M48, Ste24p Tcr_0018 128 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 78484580 Nonpathogen - hypothetical protein Tcr_0235 10 COG1641 COG1641, Uncharacterized conserved protein Function unknown 78484940 Common - Asparagine synthase, glutamine-hydrolyzing Tcr_0595 161 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 78486151 Common - metalloendopeptidase, putative, glycoprotease family Tcr_1810 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 78484683 Common - 6-aminohexanoate-dimer hydrolase Tcr_0338 61 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 78485005 Nonpathogen - hypothetical protein Tcr_0660 1 None None None 78486490 Common - ATP-dependent DNA helicase RecG Tcr_2153 211 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 78485019 Common - Protein of unknown function DUF847 Tcr_0674 15 COG3926 zliS, Putative secretion activating protein General function prediction only 78485591 Common - hypothetical protein Tcr_1247 50 COG3150 COG3150, Predicted esterase General function prediction only 78484652 Common rplE 50S ribosomal protein L5 Tcr_0307 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 78484958 Common - ribosomal-protein-alanine acetyltransferase Tcr_0613 149 COG0456 RimI, Acetyltransferases General function prediction only 78484859 Common - hypothetical protein Tcr_0514 9 None None None 78485324 Common - Protein of unknown function DUF140 Tcr_0980 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 78485762 Common - hypothetical protein Tcr_1419 2 None None None 78484932 Common - cell division protein FtsA Tcr_0587 183 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 78485274 Common - hypothetical protein Tcr_0929 4 None None None 78485985 Nonpathogen - hypothetical protein Tcr_1644 7 None None None 78484711 Common - TIR Tcr_0366 14 COG4916 COG4916, Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain Function unknown 78485494 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) Tcr_1150 199 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 78485980 Common - lipoyl synthase Tcr_1639 190 COG0320 LipA, Lipoate synthase Coenzyme metabolism 78486528 Common queF 7-cyano-7-deazaguanine reductase Tcr_2191 101 COG2904 COG2904, Uncharacterized protein conserved in bacteria Function unknown 78485102 Common - MCP methyltransferase, CheR-type Tcr_0757 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 78485954 Common - CheD, stimulates methylation of MCP proteins Tcr_1613 86 COG1871 CheD, Chemotaxis protein; stimulates methylation of MCP proteins Cell motility and secretion / Signal transduction mechanisms 78484718 Common - hypothetical protein Tcr_0373 32 None None None 78486506 Common - ATP synthase F0, B subunit Tcr_2169 180 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 78484720 Common - hypothetical protein Tcr_0375 3 None None None 78484912 Common - Cell cycle protein Tcr_0567 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 78485061 Common - Aminotransferase, class IV Tcr_0716 159 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 78484597 Common - General secretion pathway protein F Tcr_0252 147 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 78485410 Common - Amino acid permease-associated region Tcr_1066 87 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 78484537 Common - methionyl-tRNA formyltransferase Tcr_0192 218 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 78486146 Nonpathogen - hypothetical protein Tcr_1805 1 None None None 78484761 Common - ApbE-like lipoprotein Tcr_0416 55 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 78484802 Common - diguanylate cyclase (GGDEF domain) Tcr_0457 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 78486370 Common - Succinate dehydrogenase, cytochrome b subunit Tcr_2031 26 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 78485464 Common - DNA polymerase III subunit epsilon Tcr_1120 80 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 78484640 Common - Ribosomal protein L3 Tcr_0295 239 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 78485596 Common - aminotransferase Tcr_1252 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 78485957 Common - inosine-5'-monophosphate dehydrogenase Tcr_1616 236 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 78484527 Common - PP-loop Tcr_0182 162 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 78485874 Common - Sulphate transporter Tcr_1533 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 78485045 Common - Phage protein D-like Tcr_0700 37 COG3500 COG3500, Phage protein D General function prediction only 78485490 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Tcr_1146 203 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 78486188 Common - diaminopimelate decarboxylase Tcr_1847 217 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 78484484 Common - Glutaredoxin-like region Tcr_0139 113 COG0678 AHP1, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 78484723 Common - hypothetical protein Tcr_0378 16 None None None 78486388 Common - hypothetical protein Tcr_2049 12 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 78484435 Common - diguanylate cyclase (GGDEF domain) with PAS/PAC sensor Tcr_0090 196 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 78486037 Common - hypothetical protein Tcr_1696 12 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 78484804 Common - hypothetical protein Tcr_0459 37 None None None 78485542 Common rpsA 30S ribosomal protein S1 Tcr_1198 219 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 78485800 Common - hypothetical protein Tcr_1459 4 None None None 78485694 Common - sarcosine oxidase subunit D Tcr_1350 12 COG4311 SoxD, Sarcosine oxidase delta subunit Amino acid transport and metabolism 78485708 Common - ribosomal protein S6 Tcr_1364 194 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 78486083 Common - Protein of unknown function DUF160 Tcr_1742 125 COG1509 KamA, Lysine 2,3-aminomutase Amino acid transport and metabolism 78484637 Common - translation elongation factor G Tcr_0292 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 78485427 Common - N-acetylmuramoyl-L-alanine amidase Tcr_1083 176 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 78484350 Common - two component transcriptional regulator, winged helix family Tcr_0004 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 78485040 Common - Phage tail sheath protein Tcr_0695 53 COG3497 COG3497, Phage tail sheath protein FI General function prediction only 78485563 Common - Bile acid:sodium symporter Tcr_1219 82 COG0385 COG0385, Predicted Na+-dependent transporter General function prediction only 78484774 Common - ATPase associated with various cellular activities, AAA_5 Tcr_0429 99 COG0714 COG0714, MoxR-like ATPases General function prediction only 78484730 Common - MotA/TolQ/ExbB proton channel Tcr_0385 87 COG1291 MotA, Flagellar motor component Cell motility and secretion 78484410 Common - Na+/Pi-cotransporter Tcr_0064 89 COG1283 NptA, Na+/phosphate symporter Inorganic ion transport and metabolism 78486416 Common - transcriptional regulator, GntR family Tcr_2078 118 COG2188 PhnF, Transcriptional regulators Transcription 78484659 Common - ribosomal protein L15 Tcr_0314 214 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 78485913 Nonpathogen - hypothetical protein Tcr_1572 1 None None None 78484417 Common - hypothetical protein Tcr_0071 25 None None None 78485308 Common - hypothetical protein Tcr_0964 40 COG2210 COG2210, Uncharacterized conserved protein Function unknown 78485549 Common - sigma-54 (RpoN) Tcr_1205 145 COG1508 RpoN, DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog Transcription 78485769 Common - Secretion protein HlyD Tcr_1427 146 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 78484607 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase Tcr_0262 179 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 78485923 Common - 3'-5' exonuclease Tcr_1582 122 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 78485418 Nonpathogen - hypothetical protein Tcr_1074 1 None None None 78486215 Common - hypothetical protein Tcr_1876 5 None None None 78486355 Nonpathogen - hypothetical protein Tcr_2016 1 None None None 78485690 Common - Glutamine amidotransferase, class-II Tcr_1346 238 COG0067 GltB, Glutamate synthase domain 1 Amino acid transport and metabolism 78485365 Common - diguanylate cyclase (GGDEF domain) Tcr_1021 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 78486523 Nonpathogen - hypothetical protein Tcr_2186 1 None None None 78485212 Common - NAD(+) kinase Tcr_0867 239 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 78485758 Common - Tripartite ATP-independent periplasmic transporter, DctQ component Tcr_1415 70 COG4665 FcbT2, TRAP-type mannitol/chloroaromatic compound transport system, small permease component Secondary metabolites biosynthesis, transport, and catabolism 78485457 Common - translation initiation factor IF-1 Tcr_1113 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 78485586 Common - HAD-superfamily hydrolase subfamily IA, variant 3 Tcr_1242 140 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 78484695 Common - methylcitrate synthase Tcr_0350 193 COG0372 GltA, Citrate synthase Energy production and conversion 78486140 Common - Creatininase Tcr_1799 86 COG1402 COG1402, Uncharacterized protein, putative amidase General function prediction only 78486350 Common - TRAP dicarboxylate transporter- DctP subunit Tcr_2011 84 COG4663 FcbT1, TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 78485813 Common - Flagellar hook capping protein Tcr_1472 116 COG1843 FlgD, Flagellar hook capping protein Cell motility and secretion 78486065 Common - type II secretion system protein Tcr_1724 72 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 78486402 Common - Protein of unknown function DUF785 Tcr_2063 38 COG4067 COG4067, Uncharacterized protein conserved in archaea Posttranslational modification, protein turnover, chaperones 78485859 Common - protein tyrosine/serine phosphatase Tcr_1518 21 COG2365 COG2365, Protein tyrosine/serine phosphatase Signal transduction mechanisms 78485206 Common - diguanylate cyclase (GGDEF domain) Tcr_0861 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 78485141 Common leuD isopropylmalate isomerase small subunit Tcr_0796 210 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 78484784 Common - phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Tcr_0439 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 78486481 Common - (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA Tcr_2144 209 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 78484388 Common - hypothetical protein Tcr_0042 2 None None None 78484895 Common - ABC transporter related Tcr_0550 249 COG4181 COG4181, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 78486069 Common - Flp pilus assembly CpaB Tcr_1728 47 COG3745 CpaB, Flp pilus assembly protein CpaB Intracellular trafficking and secretion 78485696 Common - formyltetrahydrofolate deformylase Tcr_1352 219 COG0788 PurU, Formyltetrahydrofolate hydrolase Nucleotide transport and metabolism 78485779 Common - Flagellar FliJ and related Tcr_1438 8 COG2882 FliJ, Flagellar biosynthesis chaperone Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 78485316 Common - sigma 54 modulation protein/ribosomal protein S30EA Tcr_0972 149 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 78485640 Common - Glycoside hydrolase, family 3-like Tcr_1296 183 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 78485172 Common - NADH-ubiquinone oxidoreductase, chain 4L Tcr_0827 75 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 78485301 Common - DNA internalization-related competence protein ComEC/Rec2 Tcr_0957 178 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 78485406 Common - diguanylate cyclase (GGDEF domain) Tcr_1062 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 78484956 Common - 2-isopropylmalate synthase Tcr_0611 215 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 78485844 Common valS valyl-tRNA synthetase Tcr_1503 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 78484520 Common - hypothetical protein Tcr_0175 22 COG3528 COG3528, Uncharacterized protein conserved in bacteria Function unknown 78484570 Common - SoxH protein-like Tcr_0225 51 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 78484400 Common - transcriptional regulator, LysR family Tcr_0054 192 COG0583 LysR, Transcriptional regulator Transcription 78484662 Common - 30S ribosomal protein S11 Tcr_0317 248 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 78485429 Common - tRNA delta(2)-isopentenylpyrophosphate transferase Tcr_1085 214 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 78485228 Common - Protein of unknown function DUF455 Tcr_0883 48 COG2833 COG2833, Uncharacterized protein conserved in bacteria Function unknown 78486221 Common - hypothetical protein Tcr_1882 45 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 78485363 Nonpathogen - hypothetical protein Tcr_1019 1 None None None 78486047 Common - RDD Tcr_1706 29 COG1714 COG1714, Predicted membrane protein/domain Function unknown 78485531 Nonpathogen - hypothetical protein Tcr_1187 5 None None None 78486280 Common - Peptidase M16-like Tcr_1941 201 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 78486181 Common - Methionine biosynthesis MetW Tcr_1840 60 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 78486057 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Tcr_1716 148 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 78485007 Nonpathogen - hypothetical protein Tcr_0662 1 None None None 78485296 Common - cytochrome c, class I Tcr_0952 31 COG2863 COG2863, Cytochrome c553 Energy production and conversion 78485374 Common - endonuclease III Tcr_1030 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 78484574 Common - hypothetical protein Tcr_0229 100 COG1238 COG1238, Predicted membrane protein Function unknown 78484836 Nonpathogen - hypothetical protein Tcr_0491 1 None None None 78485000 Common - Pseudouridine synthase Tcr_0655 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 78484798 Common - Outer membrane efflux protein Tcr_0453 77 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 78486246 Common - divalent heavy-metal cations transporter Tcr_1907 12 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 78484476 Nonpathogen - hypothetical protein Tcr_0131 1 None None None 78484716 Nonpathogen - hypothetical protein Tcr_0371 1 None None None 78486482 Common - hypothetical protein Tcr_2145 24 None None None 78485723 Nonpathogen - hypothetical protein Tcr_1379 1 None None None 78484920 Common - ABC-3 Tcr_0575 190 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 78485854 Nonpathogen - hypothetical protein Tcr_1513 1 None None None 78484407 Common - NADH dehydrogenase (quinone) Tcr_0061 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 78484469 Common - nuclease (SNase-like) Tcr_0124 11 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 78485503 Common - Molybdopterin oxidoreductase Tcr_1159 187 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 78486009 Common - Rhodanese-like Tcr_1668 8 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 78485674 Common - SecF protein Tcr_1330 211 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 78485937 Common - hypothetical protein Tcr_1596 14 None None None 78484704 Common - OmpA/MotB Tcr_0359 74 COG1360 MotB, Flagellar motor protein Cell motility and secretion 78484972 Common - D-3-phosphoglycerate dehydrogenase Tcr_0627 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 78486508 Common - F0F1 ATP synthase subunit A Tcr_2171 206 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 78485839 Common - hypothetical protein Tcr_1498 16 None None None 78484831 Common - Protein of unknown function DUF163 Tcr_0486 167 COG1576 COG1576, Uncharacterized conserved protein Function unknown 78485671 Common - hypothetical protein Tcr_1327 74 COG2983 COG2983, Uncharacterized conserved protein Function unknown 78485123 Common - hypothetical protein Tcr_0778 5 None None None 78485286 Nonpathogen - hypothetical protein Tcr_0942 1 None None None 78485584 Common - Cell division protein-like Tcr_1240 13 COG3115 ZipA, Cell division protein Cell division and chromosome partitioning 78485866 Common - pantoate-beta-alanine ligase Tcr_1525 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 78485390 Common - phosphoribosylformylglycinamidine cyclo-ligase Tcr_1046 232 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 78486258 Common - ribosomal protein L33 Tcr_1919 125 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 78484529 Common - 2',5' RNA ligase Tcr_0184 30 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 78485081 Common - DNA repair protein RecO Tcr_0736 54 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 78485619 Common - beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ Tcr_1275 187 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 78485146 Common - tRNA pseudouridine synthase A Tcr_0801 234 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 78485433 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Tcr_1089 179 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 78484840 Common - isoleucyl-tRNA synthetase Tcr_0495 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 78484415 Common - Major facilitator superfamily MFS_1 Tcr_0069 94 None None None 78485032 Common - Phage baseplate assembly protein V Tcr_0687 19 COG4540 gpV, Phage P2 baseplate assembly protein gpV General function prediction only 78485625 Common - undecaprenyl diphosphate synthase Tcr_1281 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 78485600 Common - protein-L-isoaspartate O-methyltransferase Tcr_1256 155 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 78485420 Common - channel protein, hemolysin III family Tcr_1076 119 COG1272 COG1272, Predicted membrane protein, hemolysin III homolog General function prediction only 78484647 Common rplP 50S ribosomal protein L16 Tcr_0302 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 78486000 Nonpathogen - hypothetical protein Tcr_1659 1 None None None 78486179 Common - Protein of unknown function YGGT Tcr_1838 106 COG0762 COG0762, Predicted integral membrane protein Function unknown 78485518 Common - ABC transporter related Tcr_1174 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 78485196 Common - hypothetical protein Tcr_0851 18 None None None 78485107 Common - Peptidylprolyl isomerase, FKBP-type Tcr_0762 133 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 78486366 Nonpathogen - TPR repeat domain protein Tcr_2027 3 COG2938 COG2938, Uncharacterized conserved protein Function unknown 78484512 Common - D-tyrosyl-tRNA deacylase Tcr_0167 139 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 78485056 Common - malonyl CoA-acyl carrier protein transacylase Tcr_0711 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 78485373 Common - hypothetical protein Tcr_1029 17 None None None 78484622 Common - adenosylmethionine-8-amino-7-oxononanoate aminotransferase Tcr_0277 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 78486076 Common - hypothetical protein Tcr_1735 4 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 78484828 Common - Heat shock protein DnaJ-like Tcr_0483 11 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 78485054 Common - fatty acid/phospholipid synthesis protein PlsX Tcr_0709 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 78485823 Common - hypothetical protein Tcr_1482 19 COG3018 COG3018, Uncharacterized protein conserved in bacteria Function unknown 78486325 Common - hypothetical protein Tcr_1986 9 None None None 78485175 Common - NADH dehydrogenase subunit N Tcr_0830 210 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 78486266 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Tcr_1927 131 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 78484988 Nonpathogen - hypothetical protein Tcr_0643 2 None None None 78486451 Common - Bilirubin oxidase Tcr_2113 125 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 78486162 Common - S-adenosylmethionine synthetase Tcr_1821 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 78485242 Common - TolA Tcr_0897 3 COG4372 COG4372, Uncharacterized protein conserved in bacteria with the myosin-like domain Function unknown 78485441 Common - Protein of unknown function DUF861 Tcr_1097 22 COG3450 COG3450, Predicted enzyme of the cupin superfamily General function prediction only 78485892 Common - hypothetical protein Tcr_1551 11 COG3317 NlpB, Uncharacterized lipoprotein Cell envelope biogenesis, outer membrane 78485719 Nonpathogen - hypothetical protein Tcr_1375 1 None None None 78485594 Common - hypothetical protein Tcr_1250 33 COG4255 COG4255, Uncharacterized protein conserved in bacteria Function unknown 78485263 Nonpathogen - hypothetical protein Tcr_0918 1 None None None 78484925 Common - FeS assembly ATPase SufC Tcr_0580 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 78484629 Common - ribosomal protein L11 Tcr_0284 246 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 78486399 Common - magnesium transporter Tcr_2060 164 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 78486190 Common - methyltransferase small Tcr_1849 135 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 78485023 Nonpathogen - hypothetical protein Tcr_0678 1 None None None 78484371 Common - Protein of unknown function DUF125, transmembrane Tcr_0025 63 COG1814 COG1814, Uncharacterized membrane protein Function unknown 78486070 Nonpathogen - hypothetical protein Tcr_1729 1 None None None 78486359 Common - hypothetical protein Tcr_2020 70 COG0390 COG0390, ABC-type uncharacterized transport system, permease component General function prediction only 78484762 Common - FMN-binding Tcr_0417 14 COG4659 RnfG, Predicted NADH:ubiquinone oxidoreductase, subunit RnfG Energy production and conversion 78485281 Common - hypothetical protein Tcr_0936 9 None None None 78485701 Nonpathogen - hypothetical protein Tcr_1357 1 None None None 78486320 Common - Biotin biosynthesis protein BioC Tcr_1981 194 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 78484617 Common - S-adenosylmethionine decarboxylase related Tcr_0272 70 COG1586 SpeD, S-adenosylmethionine decarboxylase Amino acid transport and metabolism 78485978 Common - Protein of unknown function DUF493 Tcr_1637 40 COG2921 COG2921, Uncharacterized conserved protein Function unknown 78484854 Common - Glycoside hydrolase, family 57 Tcr_0509 35 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 78485667 Common - hypothetical protein Tcr_1323 7 None None None 78485850 Common - NAD-dependent epimerase/dehydratase Tcr_1509 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 78485565 Common - Phosphonate-binding periplasmic protein Tcr_1221 61 COG3221 PhnD, ABC-type phosphate/phosphonate transport system, periplasmic component Inorganic ion transport and metabolism 78486106 Nonpathogen - hypothetical protein Tcr_1765 3 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 78486375 Common - Peptidase M52, hydrogen uptake protein Tcr_2036 63 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 78485902 Nonpathogen - hypothetical protein Tcr_1561 1 COG3027 COG3027, Uncharacterized protein conserved in bacteria Function unknown 78486298 Nonpathogen - cytochrome oxidase maturation protein, cbb3-type Tcr_1959 1 COG3197 FixS, Uncharacterized protein, possibly involved in nitrogen fixation Inorganic ion transport and metabolism 78485999 Common apaH diadenosine tetraphosphatase Tcr_1658 116 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 78485353 Common - ADP-ribosylation/Crystallin J1 Tcr_1009 16 COG1397 DraG, ADP-ribosylglycohydrolase Posttranslational modification, protein turnover, chaperones 78484844 Common - putative RNA methylase Tcr_0499 150 COG0116 COG0116, Predicted N6-adenine-specific DNA methylase DNA replication, recombination, and repair 78484884 Common - Phosphate transport system permease protein 1 Tcr_0539 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 78485574 Common - Sua5/YciO/YrdC/YwlC Tcr_1230 199 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 78485816 Common - hypothetical protein Tcr_1475 4 None None None 78486530 Common - cation diffusion facilitator family transporter Tcr_2193 31 COG3965 COG3965, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 78486501 Common - ATP synthase F1, epsilon subunit Tcr_2164 152 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 78484551 Common - Type I secretion membrane fusion protein, HlyD Tcr_0206 129 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 78485966 Common - Fe-S metabolism associated SufE Tcr_1625 97 COG2166 COG2166, SufE protein probably involved in Fe-S center assembly General function prediction only 78484486 Nonpathogen - hypothetical protein Tcr_0141 1 None None None 78486122 Common - carboxyl-terminal protease Tcr_1781 182 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 78486512 Common - Cobyrinic acid a,c-diamide synthase Tcr_2175 224 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 78486207 Common - Glyceraldehyde 3-phosphate dehydrogenase Tcr_1868 201 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 78486237 Common - Protein of unknown function DUF81 Tcr_1898 36 COG0730 COG0730, Predicted permeases General function prediction only 78484943 Common - N-acetylglutamate synthase Tcr_0598 178 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 78485244 Common - OmpA/MotB Tcr_0899 148 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 78486443 Common - Cytochrome c, class I Tcr_2105 35 COG3258 COG3258, Cytochrome c Energy production and conversion 78486391 Common - exonuclease III Tcr_2052 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 78485506 Common - Molybdopterin binding domain MoeA Tcr_1162 196 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 78485115 Common - diguanylate phosphodiesterase (EAL domain) Tcr_0770 157 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 78485930 Common - aspartate kinase Tcr_1589 233 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 78484733 Common - modification methylase, HemK family Tcr_0388 226 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 78485781 Common - Flagellar assembly protein FliH Tcr_1440 51 COG1317 FliH, Flagellar biosynthesis/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 78486272 Common - uncharacterized conserved coiled coil protein Tcr_1933 18 None None None 78484672 Common - single-strand binding protein Tcr_0327 211 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 78486343 Common - methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor Tcr_2004 166 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 78485321 Common - K+-dependent Na+/Ca+ exchanger related-protein Tcr_0977 124 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 78485881 Nonpathogen - hypothetical protein Tcr_1540 1 None None None 78486497 Common - hypothetical protein Tcr_2160 10 None None None 78486473 Common - 3-dehydroquinate synthase Tcr_2136 208 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 78486099 Common - Thiopurine S-methyltransferase Tcr_1758 34 None None None 78484604 Common - General secretion pathway M protein Tcr_0259 3 COG3149 PulM, Type II secretory pathway, component PulM Intracellular trafficking and secretion 78485551 Common - arsenate reductase Tcr_1207 112 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 78485612 Common - Peptidase M22, glycoprotease Tcr_1268 184 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 118139514 Common - hypothetical protein Tcr_0966 23 None None None 78485237 Common - crossover junction endodeoxyribonuclease RuvC Tcr_0892 198 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 78484392 Nonpathogen - hypothetical protein Tcr_0046 3 None None None 78485066 Common - ABC transporter related Tcr_0721 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 78485744 Common - riboflavin biosynthesis protein RibD Tcr_1400 227 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 78484413 Common - Oligopeptidase A Tcr_0067 128 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 78484771 Common - transcriptional regulator, LysR family Tcr_0426 192 COG0583 LysR, Transcriptional regulator Transcription 78485604 Common - enolase Tcr_1260 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 78486209 Common - permease Tcr_1870 92 COG0701 COG0701, Predicted permeases General function prediction only 78485478 Common - ABC transporter related Tcr_1134 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 78486455 Nonpathogen - hypothetical protein Tcr_2117 1 None None None 78485820 Common - FlgN Tcr_1479 2 None None None 78484743 Nonpathogen - hypothetical protein Tcr_0398 1 None None None 78484735 Common - glutamyl-tRNA reductase Tcr_0390 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 78485796 Common - Acylneuraminate cytidylyltransferase Tcr_1455 68 COG1083 NeuA, CMP-N-acetylneuraminic acid synthetase Cell envelope biogenesis, outer membrane 78484599 Nonpathogen - General secretion pathway protein H Tcr_0254 1 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 78486060 Common - Hydroxymethylglutaryl-coenzyme A synthase Tcr_1719 75 COG3425 PksG, 3-hydroxy-3-methylglutaryl CoA synthase Lipid metabolism 78484362 Common - RNA-binding S4 Tcr_0016 105 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 78485254 Nonpathogen - hypothetical protein Tcr_0909 1 None None None 78484583 Common - Protein of unknown function DUF709 Tcr_0238 34 COG3100 COG3100, Uncharacterized protein conserved in bacteria Function unknown 78484613 Common - anthranilate phosphoribosyltransferase Tcr_0268 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 78485683 Common - nitrogen regulatory protein P-II (GlnB, GlnK) Tcr_1339 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 78484888 Common - Phosphate transporter Tcr_0543 135 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 78485857 Common - Lipopolysaccharide heptosyltransferase I Tcr_1516 73 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 78485302 Common - tetraacyldisaccharide 4'-kinase Tcr_0958 125 COG1663 LpxK, Tetraacyldisaccharide-1-P 4'-kinase Cell envelope biogenesis, outer membrane 78486287 Common - Biotin--acetyl-CoA-carboxylase ligase Tcr_1948 187 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 78486025 Common - Glycosyl transferase, family 2 Tcr_1684 186 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 78485347 Common - Dihydrolipoamide dehydrogenase Tcr_1003 244 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 78485657 Common - hypothetical protein Tcr_1313 40 COG3663 Mug, G:T/U mismatch-specific DNA glycosylase DNA replication, recombination, and repair 78485771 Common - cation diffusion facilitator family transporter Tcr_1429 201 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 78485396 Nonpathogen - hypothetical protein Tcr_1052 2 None None None 78485027 Common - hypothetical protein Tcr_0682 19 None None None 78485152 Common - Sporulation related Tcr_0807 3 COG3087 FtsN, Cell division protein Cell division and chromosome partitioning 78485331 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase Tcr_0987 213 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 78484691 Common - Chaperonin Cpn60/TCP-1 Tcr_0346 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 78486089 Common - Leucyl aminopeptidase Tcr_1748 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 78484567 Common - Aldehyde dehydrogenase Tcr_0222 221 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 78486411 Nonpathogen - hypothetical protein Tcr_2072 1 None None None 78485338 Common - DNA repair protein RadA Tcr_0994 208 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 78485576 Common - intracellular septation protein A Tcr_1232 90 COG2917 COG2917, Intracellular septation protein A Cell division and chromosome partitioning 78484967 Common - histidyl-tRNA synthetase Tcr_0622 247 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 78484698 Common - SirA-like Tcr_0353 73 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 78486467 Common - Adenosylhomocysteine nucleosidase Tcr_2130 104 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 78485159 Common - phosphoglucosamine mutase Tcr_0814 242 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 78484440 Common - ATPase associated with various cellular activities, AAA_3 Tcr_0095 172 COG0714 COG0714, MoxR-like ATPases General function prediction only 78486418 Common - ABC transporter related Tcr_2080 249 COG3638 COG3638, ABC-type phosphate/phosphonate transport system, ATPase component Inorganic ion transport and metabolism 78485721 Common - diguanylate cyclase (GGDEF domain) Tcr_1377 177 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 78484471 Common rho transcription termination factor Rho Tcr_0126 202 COG1158 Rho, Transcription termination factor Transcription 78485910 Common - putative thioredoxin Tcr_1569 128 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 78485684 Common - ammonium transporter Tcr_1340 201 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 78485306 Common - Periplasmic binding protein Tcr_0962 156 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 78484639 Common - ribosomal protein S10 Tcr_0294 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 78484609 Common - ribulose-phosphate 3-epimerase Tcr_0264 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 78485042 Nonpathogen - hypothetical protein Tcr_0697 1 None None None 78484768 Common - ATPase associated with various cellular activities, AAA_5 Tcr_0423 101 COG0714 COG0714, MoxR-like ATPases General function prediction only 78484352 Common - Outer membrane protein-like Tcr_0006 15 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 78485142 Common - 3-isopropylmalate dehydrogenase Tcr_0797 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 78485135 Common - Elongation factor P/YeiP Tcr_0790 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 78486494 Common - hypothetical protein Tcr_2157 19 COG1416 COG1416, Uncharacterized conserved protein Function unknown 78484600 Nonpathogen - General secretion pathway protein I Tcr_0255 1 COG4967 PilV, Tfp pilus assembly protein PilV Cell motility and secretion / Intracellular trafficking and secretion 78485090 Common flhF flagellar biosynthesis regulator FlhF Tcr_0745 244 COG1419 FlhF, Flagellar GTP-binding protein Cell motility and secretion 78484437 Common - Rhodanese-like Tcr_0092 54 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 78485756 Common - Gamma-glutamyltransferase Tcr_1413 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 78486357 Nonpathogen - hypothetical protein Tcr_2018 2 None None None 78485810 Common - hypothetical protein Tcr_1469 126 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 78485688 Common - Ferredoxin-dependent glutamate synthase Tcr_1344 210 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 78485448 Common - hypothetical protein Tcr_1104 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 78485340 Common - hypothetical protein Tcr_0996 216 COG4536 CorB, Putative Mg2+ and Co2+ transporter CorB Inorganic ion transport and metabolism 78486532 Common trmE tRNA modification GTPase TrmE Tcr_2195 222 COG0486 ThdF, Predicted GTPase General function prediction only 78485201 Common - Metal-dependent protein hydrolase Tcr_0856 17 COG4286 COG4286, Uncharacterized conserved protein related to MYG1 family Function unknown 78484873 Common - hypothetical protein Tcr_0528 14 COG4902 COG4902, Uncharacterized protein conserved in archaea Function unknown 78486225 Common - hypothetical protein Tcr_1886 5 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 78484772 Common rbcL ribulose bisophosphate carboxylase Tcr_0427 67 COG1850 RbcL, Ribulose 1,5-bisphosphate carboxylase, large subunit Carbohydrate transport and metabolism 78486520 Common - transcriptional regulator, XRE family Tcr_2183 52 COG3655 COG3655, Predicted transcriptional regulator Transcription 78485208 Common - DTW Tcr_0863 35 COG3148 COG3148, Uncharacterized conserved protein Function unknown 78484498 Common - shikimate 5-dehydrogenase Tcr_0153 223 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 78485834 Common - thiamine biosynthesis protein ThiI Tcr_1493 94 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 78485471 Common - cyclic nucleotide-binding domain (cNMP-BD) protein Tcr_1127 42 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 78485785 Common - two component, sigma54 specific, transcriptional regulator, Fis family Tcr_1444 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 78485946 Common - hypothetical protein Tcr_1605 18 None None None 78485327 Nonpathogen - hypothetical protein Tcr_0983 1 COG3113 COG3113, Predicted NTP binding protein (contains STAS domain) General function prediction only 78486063 Nonpathogen - TPR repeat domain protein Tcr_1722 5 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 78485994 Common - Aminoglycoside phosphotransferase Tcr_1653 90 COG3178 COG3178, Predicted phosphotransferase related to Ser/Thr protein kinases General function prediction only 78485809 Common - Flagellar L-ring protein Tcr_1468 97 COG2063 FlgH, Flagellar basal body L-ring protein Cell motility and secretion 78485544 Nonpathogen - hypothetical protein Tcr_1200 1 COG5416 COG5416, Uncharacterized integral membrane protein Function unknown 78485956 Common guaA bifunctional GMP synthase/glutamine amidotransferase protein Tcr_1615 240 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 78484883 Common - Phosphate transport system permease protein 2 Tcr_0538 221 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 78485412 Common - Protein of unknown function DUF6, transmembrane Tcr_1068 25 None None None 78485492 Nonpathogen - hypothetical protein Tcr_1148 2 None None None 78485010 Nonpathogen - hypothetical protein Tcr_0665 4 None None None 78486144 Common - Beta-lactamase-like Tcr_1803 93 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 78486249 Common - hypothetical protein Tcr_1910 9 None None None 78485182 Common - hypothetical protein Tcr_0837 15 None None None 78484729 Common - DNA topoisomerase IV subunit A Tcr_0384 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 78484539 Common - DNA processing protein DprA, putative Tcr_0194 210 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 78485063 Common - Thymidylate kinase Tcr_0718 226 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 78485104 Common - methyl-accepting chemotaxis sensory transducer Tcr_0759 19 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 78486186 Nonpathogen - hypothetical protein Tcr_1845 1 None None None 78486318 Common - 8-amino-7-oxononanoate synthase Tcr_1979 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 78484974 Common - Cytochrome c, class I Tcr_0629 11 COG2863 COG2863, Cytochrome c553 Energy production and conversion 78485083 Common - holo-(acyl-carrier-protein) synthase Tcr_0738 161 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 78484992 Common - ribosomal protein S16 Tcr_0647 203 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 78485422 Nonpathogen - hypothetical protein Tcr_1078 3 None None None 78485673 Nonpathogen - hypothetical protein Tcr_1329 1 None None None 78485983 Common - Integrase, catalytic region Tcr_1642 143 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 78485344 Common - NUDIX hydrolase Tcr_1000 112 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 78484863 Common - GCN5-related N-acetyltransferase Tcr_0518 30 COG0456 RimI, Acetyltransferases General function prediction only 78485272 Common - hypothetical protein Tcr_0927 54 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 78485692 Nonpathogen - hypothetical protein Tcr_1348 1 None None None 78484930 Common - D-alanine--D-alanine ligase Tcr_0585 215 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 78486386 Common - Rhodanese-like Tcr_2047 148 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 78484905 Common - cell division protein FtsZ Tcr_0560 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 78486460 Common - hypothetical protein Tcr_2122 6 None None None 78484630 Common - ribosomal protein L1 Tcr_0285 246 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 78485878 Common - Major facilitator superfamily MFS_1 Tcr_1537 78 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 78484800 Common - Acriflavin resistance protein Tcr_0455 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 78485077 Common - GTP-binding protein LepA Tcr_0732 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 78484525 Common - ABC transporter related Tcr_0180 249 COG4559 COG4559, ABC-type hemin transport system, ATPase component Inorganic ion transport and metabolism 78486013 Common - DNA ligase Tcr_1672 31 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 78485125 Common - hypothetical protein Tcr_0780 120 COG2353 COG2353, Uncharacterized conserved protein Function unknown 78484399 Common - Nitroreductase Tcr_0053 55 COG0778 NfnB, Nitroreductase Energy production and conversion 78486316 Common - hypothetical protein Tcr_1977 167 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 78485070 Common - peptide chain release factor 2 Tcr_0725 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 78485876 Common - hypothetical protein Tcr_1535 20 None None None 78486449 Common - Protein of unknown function DUF302 Tcr_2111 27 COG3439 COG3439, Uncharacterized conserved protein Function unknown 78484879 Common - branched-chain amino acid aminotransferase Tcr_0534 218 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 78484544 Common - Sporulation related Tcr_0199 17 COG3087 FtsN, Cell division protein Cell division and chromosome partitioning 78485959 Common - hypothetical protein Tcr_1618 19 COG3235 COG3235, Predicted membrane protein Function unknown 78485003 Common - C-5 cytosine-specific DNA methylase Tcr_0658 9 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 78485598 Common - Peptidase M23B Tcr_1254 175 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 78485485 Common - NRAMP family Mn2+/Fe2+ transporters Tcr_1141 106 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 78484564 Common - Peptidase M20D, amidohydrolase Tcr_0219 167 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 78485501 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Tcr_1157 199 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 78486255 Common - 4-hydroxybenzoyl-CoA thioesterase Tcr_1916 46 COG0824 FcbC, Predicted thioesterase General function prediction only 78485996 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Tcr_1655 153 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 78484792 Common - FxsA cytoplasmic membrane protein Tcr_0447 11 COG3030 FxsA, Protein affecting phage T7 exclusion by the F plasmid General function prediction only 78486139 Common - Glutamate--ammonia ligase Tcr_1798 221 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 78485832 Common - dihydrolipoamide dehydrogenase Tcr_1491 230 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 78485199 Common - hypothetical protein Tcr_0854 40 COG3002 COG3002, Uncharacterized protein conserved in bacteria Function unknown 78485928 Common - OmpA/MotB Tcr_1587 143 COG1360 MotB, Flagellar motor protein Cell motility and secretion 78484702 Common - Phospholipid/glycerol acyltransferase Tcr_0357 147 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 78485864 Common - OmpA/MotB Tcr_1523 130 COG1360 MotB, Flagellar motor protein Cell motility and secretion 78484491 Common - thiamine biosynthesis protein ThiS Tcr_0146 28 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 78486309 Common - Phosphoribosyl-ATP pyrophosphohydrolase Tcr_1970 179 COG0140 HisI, Phosphoribosyl-ATP pyrophosphohydrolase Amino acid transport and metabolism 78486172 Nonpathogen - hypothetical protein Tcr_1831 2 None None None 78486114 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Tcr_1773 178 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 78486217 Common - 2-isopropylmalate synthase Tcr_1878 211 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 78485284 Nonpathogen - hypothetical protein Tcr_0940 3 None None None 78484927 Common - cysteine desulfurase, SufS subfamily Tcr_0582 238 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 78485385 Common - PAS/PAC sensor signal transduction histidine kinase Tcr_1041 211 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 78485294 Common - ATP-dependent helicase HrpA Tcr_0950 131 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 78486192 Common - diguanylate cyclase (GGDEF domain) Tcr_1851 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 78485030 Nonpathogen - hypothetical protein Tcr_0685 1 None None None 78485148 Common - tryptophan synthase subunit beta Tcr_0803 226 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 78484422 Common - ATPase associated with various cellular activities, AAA_3 Tcr_0076 183 COG0714 COG0714, MoxR-like ATPases General function prediction only 78485424 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Tcr_1080 173 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 78484714 Nonpathogen - hypothetical protein Tcr_0369 1 None None None 78486177 Common - Glu/Leu/Phe/Val dehydrogenase Tcr_1836 175 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 78485435 Common - HflC protein Tcr_1091 191 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 78486426 Common - amidohydrolase-like Tcr_2088 60 COG3454 COG3454, Metal-dependent hydrolase involved in phosphonate metabolism Inorganic ion transport and metabolism 78485751 Common - hypothetical protein Tcr_1407 64 COG2914 COG2914, Uncharacterized protein conserved in bacteria Function unknown 78485890 Common - Sulfate thiol esterase Tcr_1549 115 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 78486007 Common - Initiation factor 3 Tcr_1666 211 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 78486295 Common - phosphoglyceromutase Tcr_1956 125 COG0696 GpmI, Phosphoglyceromutase Carbohydrate transport and metabolism 78485194 Nonpathogen - hypothetical protein Tcr_0849 1 None None None 78486348 Common - DEAD/DEAH box helicase-like Tcr_2009 233 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 78484821 Common - Transporter-associated region Tcr_0476 218 COG4535 CorC, Putative Mg2+ and Co2+ transporter CorC Inorganic ion transport and metabolism 78485609 Common - Protein of unknown function DUF181 Tcr_1265 42 COG1944 COG1944, Uncharacterized conserved protein Function unknown 78485516 Common - Lipoprotein releasing system, transmembrane protein, LolC/E family Tcr_1172 198 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 78485214 Common - GrpE protein Tcr_0869 231 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 78485092 Common - sigma 28 (Flagella/Sporulation) Tcr_0747 216 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 78484447 Common - thioredoxin Tcr_0102 233 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 78485842 Nonpathogen - hypothetical protein Tcr_1501 1 None None None 78485408 Nonpathogen - hypothetical protein Tcr_1064 1 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 78485329 Common - ABC-2 Tcr_0985 163 COG1511 COG1511, Predicted membrane protein Function unknown 78486223 Common - transcriptional regulator, TetR family Tcr_1884 68 COG1309 AcrR, Transcriptional regulator Transcription 78485179 Nonpathogen - hypothetical protein Tcr_0834 1 None None None 78485164 Common - NADH (or F420H2) dehydrogenase, subunit C Tcr_0819 170 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 78486408 Common - Protein of unknown function DUF302 Tcr_2069 22 COG3439 COG3439, Uncharacterized conserved protein Function unknown 78484572 Common - response regulator receiver (CheY-like) modulated diguanylate phosphodiesterase (EAL domain) Tcr_0227 164 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 78486049 Common - Pseudouridine synthase Tcr_1708 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 78485170 Common - NADH dehydrogenase subunit I Tcr_0825 193 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 78484938 Nonpathogen - hypothetical protein Tcr_0593 1 None None None 78484633 Common - DNA-directed RNA polymerase, beta subunit Tcr_0288 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 78484586 Common - cation diffusion facilitator family transporter Tcr_0241 203 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 78485337 Common - Cytochrome c1 Tcr_0993 62 COG2857 CYT1, Cytochrome c1 Energy production and conversion 78485015 Nonpathogen - hypothetical protein Tcr_0670 2 None None None 78485567 Common - Sodium/calcium exchanger membrane region Tcr_1223 100 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 78484834 Common - Phospholipase A1 Tcr_0489 52 COG2829 PldA, Outer membrane phospholipase A Cell envelope biogenesis, outer membrane 78486290 Common - tRNA/rRNA methyltransferase (SpoU) Tcr_1951 168 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 78484576 Common - (2Fe-2S)-binding Tcr_0231 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 78484838 Common - integral membrane protein MviN Tcr_0493 193 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 78486282 Nonpathogen - hypothetical protein Tcr_1943 7 None None None 78486034 Common - hypothetical protein Tcr_1693 209 COG0313 COG0313, Predicted methyltransferases General function prediction only 78486432 Nonpathogen - hypothetical protein Tcr_2094 1 None None None 78484405 Common - putative monovalent cation/H+ antiporter subunit F Tcr_0059 76 COG2212 MnhF, Multisubunit Na+/H+ antiporter, MnhF subunit Inorganic ion transport and metabolism 78486213 Common - Cobalamin synthesis protein/P47K Tcr_1874 127 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 78485676 Common - preprotein translocase, YajC subunit Tcr_1332 124 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 78486277 Common - LrgB-like protein Tcr_1938 84 COG1346 LrgB, Putative effector of murein hydrolase Cell envelope biogenesis, outer membrane 78485203 Common - putative prophage repressor Tcr_0858 149 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 78486097 Common nudE ADP-ribose diphosphatase NudE Tcr_1756 106 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 78485968 Common gatB aspartyl/glutamyl-tRNA amidotransferase subunit B Tcr_1627 213 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 78486368 Common - succinate dehydrogenase, flavoprotein subunit Tcr_2029 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 78485249 Common - Iron dependent repressor Tcr_0904 109 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 78486352 Nonpathogen - hypothetical protein Tcr_2013 1 None None None 78484514 Common - GTP-binding protein TypA Tcr_0169 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 78486514 Common - tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA Tcr_2177 192 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 78484466 Common - hypothetical protein Tcr_0121 72 COG2924 COG2924, Uncharacterized protein conserved in bacteria Function unknown 78485525 Common - Short-chain dehydrogenase/reductase SDR Tcr_1181 236 COG0623 FabI, Enoyl- acyl-carrier-protein 78485860 Common - Lipid A export ATP-binding/permease protein MsbA Tcr_1519 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 78484945 Nonpathogen - hypothetical protein Tcr_0600 2 None None None 78486240 Common - hypothetical protein Tcr_1901 33 None None None 78484579 Common - hypothetical protein Tcr_0234 59 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 78485971 Common - cell shape determining protein, MreB/Mrl family Tcr_1630 235 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 78485733 Common - 6-pyruvoyl tetrahydropterin synthase and hypothetical protein Tcr_1389 142 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 78486445 Nonpathogen - dithiol-disulfide isomerase involved in polyketide biosynthesis-like Tcr_2107 6 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 78485700 Common - MATE efflux family protein Tcr_1356 178 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 78486518 Common - NnrS Tcr_2181 54 COG3213 NnrS, Uncharacterized protein involved in response to NO Inorganic ion transport and metabolism 78486270 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) Tcr_1931 200 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 78484750 Common - diaminopimelate epimerase Tcr_0405 203 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 78485653 Common - Glutathione S-transferase-like Tcr_1309 89 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 78486090 Common - DNA polymerase III chi subunit, HolC Tcr_1749 48 COG2927 HolC, DNA polymerase III, chi subunit DNA replication, recombination, and repair 78485378 Common - electron transport complex, RnfABCDGE type, C subunit Tcr_1034 98 COG4656 RnfC, Predicted NADH:ubiquinone oxidoreductase, subunit RnfC Energy production and conversion 78486260 Common - formamidopyrimidine-DNA glycosylase Tcr_1921 182 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 78485076 Common - Peptidase S1C, Do Tcr_0731 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 78485825 Common - hypothetical protein Tcr_1484 15 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 78486104 Common nrdB ribonucleotide-diphosphate reductase subunit beta Tcr_1763 156 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 78484420 Common - hypothetical protein Tcr_0074 6 None None None 118139516 Common - hypothetical protein Tcr_1308 7 None None None 78485052 Common - Protein of unknown function DUF177 Tcr_0707 19 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 78486327 Common - hypothetical protein Tcr_1988 5 COG3184 COG3184, Uncharacterized protein conserved in bacteria Function unknown 78485109 Common - Cell divisionFtsK/SpoIIIE Tcr_0764 198 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 78485642 Common - Binding-protein-dependent transport systems inner membrane component Tcr_1298 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 78484856 Common - glycogen branching enzyme Tcr_0511 153 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 78484455 Common - argininosuccinate lyase Tcr_0110 233 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 78485455 Common - ATP-dependent Clp protease adaptor protein ClpS Tcr_1111 119 COG2127 COG2127, Uncharacterized conserved protein Function unknown 78484875 Common - hypothetical protein Tcr_0530 191 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 78485665 Common - Isoprenylcysteine carboxyl methyltransferase Tcr_1321 36 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 78484825 Common - hypothetical protein Tcr_0480 5 COG2980 RlpB, Rare lipoprotein B Cell envelope biogenesis, outer membrane 78486160 Common - phosphoribosylaminoimidazole carboxylase, catalytic subunit Tcr_1819 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 78484558 Common - Methyltransferase small Tcr_0213 81 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 78485760 Nonpathogen - hypothetical protein Tcr_1417 8 None None None 78486269 Common - Coenzyme A biosynthesis protein Tcr_1930 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 78484815 Common - two component transcriptional regulator, Fis family Tcr_0470 219 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 78485900 Common - Peptidase M24 Tcr_1559 236 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 78484478 Common - metal dependent phosphohydrolase Tcr_0133 111 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 78485592 Common - Phosphoesterase, RecJ-like Tcr_1248 193 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 78484619 Common - Ornithine decarboxylase Tcr_0274 214 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 78484922 Common - Periplasmic solute binding protein Tcr_0577 162 COG4531 ZnuA, ABC-type Zn2+ transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 78484753 Common - Nitroreductase Tcr_0408 64 COG0778 NfnB, Nitroreductase Energy production and conversion 78485728 Common fumC fumarate hydratase Tcr_1384 239 COG0114 FumC, Fumarase Energy production and conversion 78484458 Common - uroporphyrinogen III methylase Tcr_0113 58 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 78485002 Nonpathogen - hypothetical protein Tcr_0657 2 None None None 78486384 Nonpathogen - hypothetical protein Tcr_2045 2 COG2143 COG2143, Thioredoxin-related protein Posttranslational modification, protein turnover, chaperones 78485944 Common - Glycosyl transferase, group 1 Tcr_1603 192 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 78484913 Common - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Tcr_0568 208 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 78485699 Common - hypothetical protein Tcr_1355 87 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 78485184 Common - Ribulose-bisphosphate carboxylase Tcr_0839 29 COG4451 RbcS, Ribulose bisphosphate carboxylase small subunit Energy production and conversion 78484990 Nonpathogen - hypothetical protein Tcr_0645 1 None None None 78485369 Common - Protein of unknown function DUF938 Tcr_1025 49 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 78485981 Common - hypothetical protein Tcr_1640 3 None None None 78486373 Nonpathogen - lipase-like Tcr_2034 5 None None None 78484488 Common - Phosphomethylpyrimidine kinase Tcr_0143 220 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 78484355 Nonpathogen - hypothetical protein Tcr_0009 1 None None None 78485414 Common - putative nucleoprotein/polynucleotide-associated enzyme Tcr_1070 28 COG3122 COG3122, Uncharacterized protein conserved in bacteria Function unknown 78485709 Common - Flavodoxin, long chain Tcr_1365 74 COG0716 FldA, Flavodoxins Energy production and conversion 78486149 Common - GatB/Yqey Tcr_1808 151 COG1610 COG1610, Uncharacterized conserved protein Function unknown 78485955 Common - Cytidine/deoxycytidylate deaminase, zinc-binding region Tcr_1614 218 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 78486087 Common - permease YjgP/YjgQ Tcr_1746 93 COG0795 COG0795, Predicted permeases General function prediction only 78485268 Common - cysteinyl-tRNA synthetase Tcr_0923 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 78484724 Common - diguanylate cyclase (GGDEF domain) with PAS/PAC sensor Tcr_0379 185 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 78485278 Common - hypothetical protein Tcr_0933 31 COG3021 COG3021, Uncharacterized protein conserved in bacteria Function unknown 78484431 Common - hypothetical protein Tcr_0086 7 COG4688 COG4688, Uncharacterized protein conserved in bacteria Function unknown 78484569 Common - hypothetical protein Tcr_0224 12 COG5379 BtaA, S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase Lipid metabolism 78485020 Nonpathogen - hypothetical protein Tcr_0675 1 None None None 78485806 Common - Protein of unknown function DUF1078 Tcr_1465 125 COG1256 FlgK, Flagellar hook-associated protein Cell motility and secretion 78484980 Common - acetolactate synthase, small subunit Tcr_0635 192 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 78484809 Common - Porin, Gram-negative type Tcr_0464 34 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 78484727 Nonpathogen - hypothetical protein Tcr_0382 1 None None None 78485171 Common - NADH-ubiquinone/plastoquinone oxidoreductase, chain 6 Tcr_0826 111 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 78485995 Common - Organic solvent tolerance protein Tcr_1654 96 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 78485231 Common - thiol-disulfide isomerase and thioredoxins Tcr_0886 15 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 78485950 Common - heat shock protein 90 Tcr_1609 150 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 78485096 Common - CheW protein Tcr_0751 52 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 78485546 Common - periplasmic sensor signal transduction histidine kinase Tcr_1202 191 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 78486462 Nonpathogen - hypothetical protein Tcr_2124 1 None None None 78485271 Common - Hydroxyacylglutathione hydrolase Tcr_0926 204 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 78484397 Common - acetolactate synthase Tcr_0051 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 78486444 Common - hypothetical protein Tcr_2106 81 COG3391 COG3391, Uncharacterized conserved protein Function unknown 78485754 Common - Phage integrase Tcr_1410 101 COG0582 XerC, Integrase DNA replication, recombination, and repair 78484442 Nonpathogen - hypothetical protein Tcr_0097 1 None None None 78486341 Common - transcriptional regulator, LysR family Tcr_2002 178 COG0583 LysR, Transcriptional regulator Transcription 78484474 Common - ABC transporter related Tcr_0129 249 COG4619 COG4619, ABC-type uncharacterized transport system, ATPase component General function prediction only 78485686 Common - Glutamine amidotransferase class-I Tcr_1342 166 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 78486242 Common - Aminotransferase, class I and II Tcr_1903 240 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 78484908 Common - UDP-N-acetylmuramyl-tripeptide synthetase Tcr_0563 213 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 78486251 Nonpathogen - hypothetical protein Tcr_1912 1 None None None 78486169 Common - Holliday junction resolvase YqgF Tcr_1828 166 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 78484603 Common - General secretion pathway L Tcr_0258 18 COG3297 PulL, Type II secretory pathway, component PulL Intracellular trafficking and secretion 78484406 Common - cation antiporter Tcr_0060 87 COG1863 MnhE, Multisubunit Na+/H+ antiporter, MnhE subunit Inorganic ion transport and metabolism 78485885 Common - hypothetical protein Tcr_1544 43 None None None 78484547 Common - Mg chelatase-related protein Tcr_0202 191 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 78485535 Common - DNA gyrase, A subunit Tcr_1191 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 78485111 Common - recombination factor protein RarA Tcr_0766 241 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 78484357 Common - Protein of unknown function DUF399 Tcr_0011 22 COG3016 PhuW, Uncharacterized iron-regulated protein Function unknown 78484451 Common - serine/threonine protein kinase Tcr_0106 129 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 78484737 Common - ribose-phosphate pyrophosphokinase Tcr_0392 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 78486522 Common - transcriptional regulator, LysR family Tcr_2185 191 COG0583 LysR, Transcriptional regulator Transcription 78486412 Nonpathogen - hypothetical protein Tcr_2073 2 None None None 78486534 Common - 60 kDa inner membrane insertion protein Tcr_2197 211 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 78484438 Common - Beta-lactamase-like Tcr_0093 181 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 78486080 Common - Glutathione S-transferase-like Tcr_1739 109 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 78485787 Common - sigma54 specific transcriptional regulator, Fis family Tcr_1446 169 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 78484936 Common - histidinol-phosphate aminotransferase Tcr_0591 233 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 78484715 Common - hypothetical protein Tcr_0370 4 None None None 78484654 Common - Ribosomal protein S8 Tcr_0309 222 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 78485163 Common - NADH dehydrogenase subunit B Tcr_0818 191 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 78485836 Common - Inositol phosphatase/fructose-1,6-bisphosphatase Tcr_1495 108 COG0158 Fbp, Fructose-1,6-bisphosphatase Carbohydrate transport and metabolism 78484686 Common - ribosomal protein L21 Tcr_0341 215 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 78486040 Common - Chromate transporter Tcr_1699 107 COG2059 ChrA, Chromate transport protein ChrA Inorganic ion transport and metabolism 78484684 Nonpathogen - hypothetical protein Tcr_0339 1 None None None 78486452 Common - Cytochrome c, class I Tcr_2114 17 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 78485186 Nonpathogen - carboxysome shell protein CsoS3 Tcr_0841 7 None None None 78485483 Common - dual specificity protein phosphatase Tcr_1139 16 COG2453 CDC14, Predicted protein-tyrosine phosphatase Signal transduction mechanisms 78485766 Nonpathogen - hypothetical protein Tcr_1424 1 None None None 78485342 Common - signal recognition particle protein Tcr_0998 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 78484632 Common - ribosomal protein L7/L12 Tcr_0287 215 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 78485452 Common - diguanylate cyclase (GGDEF domain) Tcr_1108 205 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 78484504 Common - molybdopterin converting factor, subunit 1 Tcr_0159 72 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 78485650 Common cysM cysteine synthase B Tcr_1306 224 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 78486430 Nonpathogen - hypothetical protein Tcr_2092 1 None None None 78484623 Nonpathogen - hypothetical protein Tcr_0278 1 None None None 78484509 Nonpathogen - hypothetical protein Tcr_0164 2 None None None 78486228 Common - dihydroorotase Tcr_1889 211 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 78484395 Common - Cytochrome c assembly protein Tcr_0049 189 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 78486051 Common - 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate Tcr_1710 109 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 78485746 Common - Glycine hydroxymethyltransferase Tcr_1402 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 78485469 Common - tRNA pseudouridine synthase B Tcr_1125 245 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 78485678 Common - S-adenosylmethionine Tcr_1334 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 78484390 Common - DNA polymerase I Tcr_0044 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 78486027 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Tcr_1686 162 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 78486019 Common - Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase Tcr_1678 165 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 78484530 Common - Tellurite resistance protein TehB Tcr_0185 45 COG0500 SmtA, SAM-dependent methyltransferases Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 78485738 Common - methyl-accepting chemotaxis sensory transducer Tcr_1394 143 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 78484665 Common - ribosomal protein L17 Tcr_0320 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 78485370 Common - Peptidylprolyl isomerase, FKBP-type Tcr_1026 134 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 78484965 Common - hypothetical protein Tcr_0620 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 78485908 Nonpathogen - hypothetical protein Tcr_1567 1 None None None 78484766 Common - Carbonate dehydratase Tcr_0421 148 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 78486058 Common - Hydroxymethylglutaryl-CoA reductase (NADPH) Tcr_1717 39 COG1257 HMG1, Hydroxymethylglutaryl-CoA reductase Lipid metabolism 78484411 Common - hypothetical protein Tcr_0065 128 COG0432 COG0432, Uncharacterized conserved protein Function unknown 78486230 Common - polyphosphate kinase Tcr_1891 161 COG0855 Ppk, Polyphosphate kinase Inorganic ion transport and metabolism 78484998 Nonpathogen - hypothetical protein Tcr_0653 1 None None None 78484361 Nonpathogen - MltA-interacting MipA Tcr_0015 8 COG3713 OmpV, Outer membrane protein V Cell envelope biogenesis, outer membrane 78485648 Common - Type I secretion outer membrane protein, TolC Tcr_1304 143 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 78485989 Common - hypothetical protein Tcr_1648 16 None None None 78484897 Common - putative lipoprotein Tcr_0552 21 None None None 78485383 Common - response regulator receiver domain protein (CheY-like) Tcr_1039 219 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 118139523 Nonpathogen - hypothetical protein; predicted periplasmic or secreted protein Tcr_2204 1 None None None 78486367 Common - succinate dehydrogenase and fumarate reductase iron-sulfur protein Tcr_2028 203 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 78485602 Common - Smr protein/MutS2-like Tcr_1258 88 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 78484748 Common - Protein of unknown function DUF971 Tcr_0403 50 COG3536 COG3536, Uncharacterized protein conserved in bacteria Function unknown 78485255 Nonpathogen - hypothetical protein Tcr_0910 12 None None None 78484954 Common - UDP-glucose 6-dehydrogenase Tcr_0609 206 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 78485097 Common - Uncharacterized cytoplasmic domain of flagellar protein FhlB-like Tcr_0752 108 COG2257 COG2257, Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB Function unknown 78485589 Nonpathogen - hypothetical protein Tcr_1245 1 None None None 78484851 Common - phosphoheptose isomerase Tcr_0506 130 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 78484795 Nonpathogen - hypothetical protein Tcr_0450 7 COG3439 COG3439, Uncharacterized conserved protein Function unknown 78484492 Common - FAD dependent oxidoreductase Tcr_0147 79 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 78485355 Common - periplasmic ATP/GTP-binding protein Tcr_1011 11 None None None 78486166 Common - Glutathione synthetase Tcr_1825 117 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 78486170 Common - aspartate carbamoyltransferase Tcr_1829 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 78486427 Common - Guanylate kinase/L-type calcium channel region Tcr_2089 45 COG3709 COG3709, Uncharacterized component of phosphonate metabolism Inorganic ion transport and metabolism 78486067 Common - Flp pilus assembly protein ATPase CpaE-like Tcr_1726 134 COG4963 CpaE, Flp pilus assembly protein, ATPase CpaE Intracellular trafficking and secretion 78485216 Common - Heat shock protein DnaJ Tcr_0871 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 78484976 Common - Transcriptional coactivator/pterin dehydratase Tcr_0631 116 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 78485711 Common - nicotinate-nucleotide pyrophosphorylase Tcr_1367 204 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 78485794 Common - Flagellin-like Tcr_1453 123 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 78485907 Common - Protein of unknown function DUF461 Tcr_1566 89 COG2847 COG2847, Uncharacterized protein conserved in bacteria Function unknown 78486536 Common - ribosomal protein L34 Tcr_2199 41 COG0230 RpmH, Ribosomal protein L34 Translation, ribosomal structure and biogenesis 78486297 Common gltD glutamate synthase subunit beta Tcr_1958 198 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 78486466 Common - S-ribosylhomocysteinase Tcr_2129 55 COG1854 LuxS, LuxS protein involved in autoinducer AI2 synthesis Signal transduction mechanisms 78485078 Common - Peptidase S26A, signal peptidase I Tcr_0733 212 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 78485323 Common - ABC transporter related Tcr_0979 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 78485168 Common - NADH dehydrogenase subunit G Tcr_0823 195 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 78485467 Common - translation initiation factor IF-2 Tcr_1123 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 78484375 Common - Sodium/sulphate symporter Tcr_0029 95 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 78486372 Common - Protein of unknown function DUF980 Tcr_2033 58 COG3228 COG3228, Uncharacterized protein conserved in bacteria Function unknown 78484868 Common - hypothetical protein Tcr_0523 17 COG2143 COG2143, Thioredoxin-related protein Posttranslational modification, protein turnover, chaperones 78486488 Common - ammonium transporter Tcr_2151 221 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 78484709 Common - DNA topoisomerase IV subunit B Tcr_0364 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 78485071 Common - lysyl-tRNA synthetase Tcr_0726 247 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 78485059 Common - Beta-ketoacyl synthase Tcr_0714 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 78486406 Common - hypothetical protein Tcr_2067 3 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 78484677 Common - N-6 DNA methylase Tcr_0332 157 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 78484827 Common - gamma-glutamyl phosphate reductase Tcr_0482 193 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 78486193 Common - Integrase, catalytic region Tcr_1852 141 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 78485470 Common - hypothetical protein Tcr_1126 36 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 78485716 Common - NAD+ synthetase Tcr_1372 237 COG0171 NadE, NAD synthase Coenzyme metabolism 78486265 Common - Molybdate ABC transporter, permease protein Tcr_1926 197 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 78484699 Common glyQ glycyl-tRNA synthetase subunit alpha Tcr_0354 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 78486395 Common - Penicillin-binding protein 1A Tcr_2056 200 COG5009 MrcA, Membrane carboxypeptidase/penicillin-binding protein Cell envelope biogenesis, outer membrane 78486201 Common - cold-shock DNA-binding domain protein Tcr_1862 181 COG1278 CspC, Cold shock proteins Transcription 78485663 Common - hypothetical protein Tcr_1319 3 None None None 78485921 Common - hypothetical protein Tcr_1580 30 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 78486038 Common - UvrD/REP helicase Tcr_1697 226 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 78486379 Common - Hydrogenase expression/formation protein HypE Tcr_2040 120 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 78484644 Common rpsS 30S ribosomal protein S19 Tcr_0299 248 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 78486321 Common - hypothetical protein Tcr_1982 4 None None None 78485050 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Tcr_0705 136 COG0546 Gph, Predicted phosphatases General function prediction only 78486262 Common - ATPase, E1-E2 type Tcr_1923 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 78486183 Nonpathogen - putative transcriptional regulator Tcr_1842 1 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 78486075 Common - diphosphomevalonate decarboxylase Tcr_1734 29 COG3407 MVD1, Mevalonate pyrophosphate decarboxylase Lipid metabolism 78486239 Common - hypothetical protein Tcr_1900 2 None None None 78484947 Common - hypothetical protein Tcr_0602 33 None None None 78486095 Common - excinuclease ABC subunit B Tcr_1754 234 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 78485049 Common - Pseudouridine synthase, RluD Tcr_0704 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 78485916 Common - Cytochrome c, class I Tcr_1575 19 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 78484552 Common - ABC transporter related Tcr_0207 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 78484468 Common - uroporphyrinogen decarboxylase Tcr_0123 181 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 78484810 Nonpathogen - hypothetical protein Tcr_0465 3 None None None 78484582 Common - Superoxide dismutase Tcr_0237 207 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 78484562 Common - Phosphoribosyl-AMP cyclohydrolase Tcr_0217 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 78485511 Common - hypothetical protein Tcr_1167 8 None None None 78485139 Common - hypothetical protein Tcr_0794 131 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 78484929 Common - UDP-N-acetylmuramate--alanine ligase Tcr_0584 211 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 78485481 Common - adenylosuccinate lyase Tcr_1137 229 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 78486346 Common - TRAP dicarboxylate transporter- DctM subunit Tcr_2007 123 COG4664 FcbT3, TRAP-type mannitol/chloroaromatic compound transport system, large permease component Secondary metabolites biosynthesis, transport, and catabolism 78484848 Common - KpsF/GutQ family protein Tcr_0503 172 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 78485426 Common - hypothetical protein Tcr_1082 173 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 78486101 Common - hypothetical protein Tcr_1760 26 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 78485137 Common - hypothetical protein Tcr_0792 4 None None None 78486276 Common - diguanylate cyclase (GGDEF domain) Tcr_1937 198 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 78484924 Common - cysteine desulfurase activator complex subunit SufB Tcr_0579 185 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 118139511 Common - NAD-dependent DNA ligase (contains BRCT domain type II)-like Tcr_0663 21 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 78484612 Common - glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase Tcr_0267 235 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 78484985 Common - TPR repeat domain protein Tcr_0640 74 COG3071 HemY, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 78485731 Common - Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Tcr_1387 223 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 78485727 Common - Hpt sensor hybrid histidine kinase Tcr_1383 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 78485446 Nonpathogen - hypothetical protein Tcr_1102 2 None None None 78486123 Common - transcriptional regulator, ArsR family Tcr_1782 155 COG0640 ArsR, Predicted transcriptional regulators Transcription 78485248 Nonpathogen - hypothetical protein Tcr_0903 1 None None None 78485560 Common - glutamyl-tRNA synthetase Tcr_1216 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 78485577 Common - YCII-related Tcr_1233 71 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 78485828 Common - transcriptional regulator, Crp/Fnr family Tcr_1487 141 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 78485990 Common - Hsp33 protein Tcr_1649 124 COG1281 COG1281, Disulfide bond chaperones of the HSP33 family Posttranslational modification, protein turnover, chaperones 78485099 Common - response regulator receiver domain protein (CheY-like) Tcr_0754 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 78486132 Common - hypothetical protein Tcr_1791 56 COG3665 COG3665, Uncharacterized conserved protein Function unknown 78486127 Nonpathogen - Amidohydrolase 2 Tcr_1786 3 None None None 78485477 Common - Secretion protein HlyD Tcr_1133 159 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 78484889 Common - Phosphate binding protein Tcr_0544 113 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 78485401 Common - cold-shock DNA-binding domain protein Tcr_1057 179 COG1278 CspC, Cold shock proteins Transcription 78485555 Common - Sodium/hydrogen exchanger Tcr_1211 122 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 78485840 Common - nitrogen regulatory protein P-II (GlnB, GlnK) Tcr_1499 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 78485330 Common - BolA-like protein Tcr_0986 52 COG5007 COG5007, Predicted transcriptional regulator, BolA superfamily Transcription 78486485 Common - ABC transporter related Tcr_2148 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 78484384 Common - putative acyl-CoA dehydrogenase Tcr_0038 96 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 78484556 Common - Iron-containing alcohol dehydrogenase Tcr_0211 174 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 78485654 Nonpathogen - hypothetical protein Tcr_1310 2 COG1416 COG1416, Uncharacterized conserved protein Function unknown 78486335 Common - ATP-dependent DNA helicase RecQ Tcr_1996 234 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 78485934 Common - CinA-like Tcr_1593 191 COG1546 CinA, Uncharacterized protein (competence- and mitomycin-induced) General function prediction only 118139518 Common - Lytic transglycosylase, catalytic Tcr_1463 117 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 78484789 Common - acetyl-CoA carboxylase, biotin carboxyl carrier protein Tcr_0444 188 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 78484424 Common - Methyltransferase, putative Tcr_0078 62 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 78484348 Common - DNA polymerase III, beta subunit Tcr_0002 216 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 78484667 Common - UBA/THIF-type NAD/FAD binding fold Tcr_0322 196 COG1179 COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Coenzyme metabolism 78486167 Common - ApbE-like lipoprotein Tcr_1826 130 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 78484404 Common - putative monovalent cation/H+ antiporter subunit G Tcr_0058 103 COG1320 MnhG, Multisubunit Na+/H+ antiporter, MnhG subunit Inorganic ion transport and metabolism 78484524 Common - transport system permease protein Tcr_0179 191 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 78486331 Common - pyridoxamine 5'-phosphate oxidase Tcr_1992 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 78485775 Common - OmpA/MotB Tcr_1434 95 COG1360 MotB, Flagellar motor protein Cell motility and secretion 78484461 Nonpathogen - hypothetical protein Tcr_0116 4 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 78484759 Common - AAA ATPase Tcr_0414 218 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 78484472 Common - thioredoxin Tcr_0127 233 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 78486010 Common - putative signal transduction protein Tcr_1669 60 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 78485622 Common - surface antigen (D15) Tcr_1278 162 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 78485615 Common - response regulator receiver (CheY-like) modulated CheW protein Tcr_1271 109 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 78486317 Common - biotin synthase Tcr_1978 182 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 78484952 Common - UTP-glucose-1-phosphate uridylyltransferase Tcr_0607 231 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 78486307 Common - Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Tcr_1968 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 78486052 Nonpathogen - hypothetical protein Tcr_1711 1 None None None 78486043 Common - transcriptional regulator, TetR family Tcr_1702 54 COG1309 AcrR, Transcriptional regulator Transcription 78485898 Common - Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family Tcr_1557 133 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 78484449 Nonpathogen - hypothetical protein Tcr_0104 1 None None None 78485569 Common - anti-sigm factor, ChrR Tcr_1225 35 COG3806 ChrR, Transcriptional activator Transcription 78485638 Common - UDP-N-acetylenolpyruvoylglucosamine reductase Tcr_1294 198 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 78486112 Common - RNA polymerase sigma factor Tcr_1771 158 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 78484516 Nonpathogen - YeeE/YedE Tcr_0171 5 None None None 78484817 Nonpathogen - methylation site Tcr_0472 7 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 78486219 Common - Beta-lactamase-like Tcr_1880 59 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 78486471 Common - sigma 32 (RpoH) Tcr_2134 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 78486434 Common - Secretion protein HlyD Tcr_2096 77 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 78485814 Common - flagellar basal-body rod protein FlgC Tcr_1473 126 COG1558 FlgC, Flagellar basal body rod protein Cell motility and secretion 78485895 Common - PhoH-like protein Tcr_1554 191 COG1875 COG1875, Predicted ATPase related to phosphate starvation-inducible protein PhoH Signal transduction mechanisms 78485221 Common - Drug resistance transporter Bcr/CflA subfamily Tcr_0876 221 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 78486137 Common - PfkB Tcr_1796 143 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 78486175 Common - hypothetical protein Tcr_1834 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 78485430 Common - Host factor Hfq Tcr_1086 127 COG1923 Hfq, Uncharacterized host factor I protein General function prediction only 78485527 Common - Binding-protein-dependent transport systems inner membrane component Tcr_1183 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 78485128 Common - peptide methionine sulfoxide reductase Tcr_0783 206 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 78485143 Common - Peptidase M23B Tcr_0798 190 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 78486224 Nonpathogen - hypothetical protein Tcr_1885 8 None None None 78486292 Common - protein-export protein SecB Tcr_1953 107 COG1952 SecB, Preprotein translocase subunit SecB Intracellular trafficking and secretion 78485004 Nonpathogen - hypothetical protein Tcr_0659 1 None None None 78484590 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Tcr_0245 235 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 78484823 Nonpathogen - hypothetical protein Tcr_0478 2 None None None 78486478 Common - 3-deoxy-manno-octulosonate cytidylyltransferase Tcr_2141 154 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 78486005 Common rplT 50S ribosomal protein L20 Tcr_1664 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 78485192 Nonpathogen - Rubrerythrin Tcr_0847 7 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 78485629 Common - ribosomal protein S2 Tcr_1285 232 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 78485645 Common - transcriptional regulator, TetR family Tcr_1301 6 COG1309 AcrR, Transcriptional regulator Transcription 78486329 Common - Protein of unknown function DUF548 Tcr_1990 54 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 78484778 Common - ABC transporter related Tcr_0433 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 78485973 Common - hypothetical protein Tcr_1632 50 COG2891 MreD, Cell shape-determining protein Cell envelope biogenesis, outer membrane 78485361 Nonpathogen - hypothetical protein Tcr_1017 1 None None None 78484891 Common - Ion transport protein Tcr_0546 30 None None None 78484942 Common - ribonuclease T Tcr_0597 50 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 78485605 Common - 2-dehydro-3-deoxyphosphooctonate aldolase Tcr_1261 186 COG2877 KdsA, 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase Cell envelope biogenesis, outer membrane 78485261 Common - Rhodanese-like Tcr_0916 131 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 78485068 Common - Methylenetetrahydrofolate dehydrogenase (NADP+) Tcr_0723 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 78485752 Common - cyclase/dehydrase Tcr_1408 102 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 78486197 Common - Heavy metal efflux pump CzcA Tcr_1856 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 78484700 Common - glycyl-tRNA synthetase, beta subunit Tcr_0355 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 78486254 Common - phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase Tcr_1915 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 78484592 Common - pyruvate kinase Tcr_0247 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 78485553 Common xseA exodeoxyribonuclease VII large subunit Tcr_1209 205 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 78485517 Common - Lipoprotein releasing system, ATP-binding protein Tcr_1173 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 78486253 Nonpathogen - hypothetical protein Tcr_1914 3 None None None 78486464 Common - transcriptional regulator, MerR family Tcr_2126 64 COG0789 SoxR, Predicted transcriptional regulators Transcription 78486056 Common - Gamma-glutamyltransferase Tcr_1715 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 78486156 Common - Protein of unknown function DUF185 Tcr_1815 94 COG1565 COG1565, Uncharacterized conserved protein Function unknown 78485444 Common - Pseudouridine synthase, Rsu Tcr_1100 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 78485462 Common - SSS sodium solute transporter superfamily Tcr_1118 183 COG4147 DhlC, Predicted symporter General function prediction only 78485748 Common - diguanylate cyclase (GGDEF domain) with PAS/PAC sensor Tcr_1404 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 78486245 Common - deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) Tcr_1906 180 COG0756 Dut, dUTPase Nucleotide transport and metabolism 78485416 Common - Beta-lactamase Tcr_1072 130 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 78486414 Common - Transposase IS3/IS911 Tcr_2075 61 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 78484605 Common - type II secretion system protein N Tcr_0260 3 None None None 78484776 Nonpathogen - hypothetical protein Tcr_0431 1 None None None 78484444 Common - von Willebrand factor, type A Tcr_0099 59 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 78485759 Common - TRAP dicarboxylate transporter- DctP subunit Tcr_1416 106 COG4663 FcbT1, TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 78486014 Common - Competence protein ComEA helix-hairpin-helix region Tcr_1673 94 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 78484518 Common - tRNA (uracil-5-)-methyltransferase Tcr_0173 166 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 78484549 Common - Type I secretion outer membrane protein, TolC Tcr_0204 126 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 78485548 Common - hypothetical protein Tcr_1204 11 COG3435 COG3435, Gentisate 1,2-dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 78486084 Common - 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferase of PMT family-like Tcr_1743 45 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 78486389 Common - hypothetical protein Tcr_2050 48 COG1444 COG1444, Predicted P-loop ATPase fused to an acetyltransferase General function prediction only 78484481 Common - Molybdopterin binding domain Tcr_0136 160 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 78484494 Common - hypothetical protein Tcr_0149 19 COG5615 COG5615, Predicted integral membrane protein Function unknown 78484877 Common - ornithine carbamoyltransferase Tcr_0532 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 78484681 Common - hypothetical protein Tcr_0336 61 COG3472 COG3472, Uncharacterized conserved protein Function unknown 78485459 Common - DNA polymerase III, alpha subunit Tcr_1115 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 78484656 Common - ribosomal protein L18 Tcr_0311 214 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 78484540 Common - response regulator receiver domain protein (CheY-like) Tcr_0195 219 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 78485117 Common - HAD-superfamily hydrolase YedP Tcr_0772 42 COG3769 COG3769, Predicted hydrolase (HAD superfamily) General function prediction only 78485764 Nonpathogen - hypothetical protein Tcr_1421 3 None None None 78485805 Common - Flagellin-like Tcr_1464 93 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 78485838 Common - Glutamate-ammonia-ligase adenylyltransferase Tcr_1497 119 COG1391 GlnE, Glutamine synthetase adenylyltransferase Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms 78485948 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Tcr_1607 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 78484634 Common - DNA-directed RNA polymerase subunit beta' Tcr_0289 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 78485037 Common - hypothetical protein Tcr_0692 11 None None None 78485276 Common - Peptidylprolyl isomerase, FKBP-type Tcr_0931 130 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 78484910 Common - phospho-N-acetylmuramoyl-pentapeptide-transferase Tcr_0565 220 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 78485891 Common - phosphoribosylformylglycinamidine synthase Tcr_1550 232 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 78486378 Common - hydrogenase nickel insertion protein HypA Tcr_2039 21 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 78485205 Common - diguanylate phosphodiesterase (EAL domain) Tcr_0860 66 COG3434 COG3434, Predicted signal transduction protein containing EAL and modified HD-GYP domains Signal transduction mechanisms 78485290 Common - Protein of unknown function DUF107 Tcr_0946 74 COG1030 NfeD, Membrane-bound serine protease (ClpP class) Posttranslational modification, protein turnover, chaperones 78485188 Nonpathogen - Ethanolamine utilization protein EutN/carboxysome structural protein Ccml Tcr_0843 7 COG4576 CcmL, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 78486354 Common - TonB-dependent receptor Tcr_2015 85 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 78486147 Common - sigma 70 (RpoD) Tcr_1806 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 78486458 Nonpathogen - hypothetical protein Tcr_2120 1 None None None 78485120 Common - Glycerate kinase Tcr_0775 81 COG1929 COG1929, Glycerate kinase Carbohydrate transport and metabolism 78486303 Common - cytochrome c oxidase, cbb3-type, subunit II Tcr_1964 82 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 78485357 Common - NAD(P)H dehydrogenase (quinone) Tcr_1013 72 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 78486142 Common - Protein of unknown function DUF6, transmembrane Tcr_1801 59 COG2962 RarD, Predicted permeases General function prediction only 78485266 Common - Peptidylprolyl isomerase Tcr_0921 200 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 78484915 Common - methyl-accepting chemotaxis sensory transducer Tcr_0570 148 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 78486017 Nonpathogen - hypothetical protein Tcr_1676 1 None None None 78485094 Common - Chemotaxis phosphatase, CheZ Tcr_0749 48 COG3143 CheZ, Chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 78484722 Common - Integrase, catalytic region Tcr_0377 55 None None None 78484864 Common - diaminobutyrate--2-oxoglutarate aminotransferase Tcr_0519 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 78485641 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) Tcr_1297 179 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 78486503 Common - ATP synthase F1, gamma subunit Tcr_2166 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 78484697 Common - Peptidase M23B Tcr_0352 189 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 78486305 Common - Imidazoleglycerol-phosphate dehydratase Tcr_1966 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 78484765 Nonpathogen - hypothetical protein Tcr_0420 2 None None None 78484982 Common - ATPase Tcr_0637 65 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 78485101 Common - hypothetical protein Tcr_0756 3 None None None 78485952 Nonpathogen - hypothetical protein Tcr_1611 5 None None None 78484807 Common - Ribosomal protein S9 Tcr_0462 218 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 78484996 Common - Tyrosine recombinase XerD Tcr_0651 232 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 78485069 Common - hypothetical protein Tcr_0724 7 None None None 78485257 Common - nitrogen regulatory protein P-II (GlnB, GlnK) Tcr_0912 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 78485633 Common dapD 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase Tcr_1289 138 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 78485074 Common - L-aspartate oxidase Tcr_0729 226 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 78485223 Common - carbamoyl-phosphate synthase, small subunit Tcr_0878 234 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 78485450 Common - hypothetical protein Tcr_1106 19 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 78484746 Common - Protein of unknown function DUF1243 Tcr_0401 24 COG3165 COG3165, Uncharacterized protein conserved in bacteria Function unknown 78485533 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Tcr_1189 185 COG0546 Gph, Predicted phosphatases General function prediction only 78486311 Common - twin-arginine translocation protein, TatA/E family Tcr_1972 54 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 118139521 Nonpathogen - Phage P2 GpE family protein Tcr_2202 1 None None None 78485939 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Tcr_1598 135 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 78485013 Common - hypothetical protein Tcr_0668 39 COG4643 COG4643, Uncharacterized protein conserved in bacteria Function unknown 78484366 Common - Polysaccharide deacetylase Tcr_0020 80 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 78484673 Common - Phage integrase Tcr_0328 21 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 78484649 Common - Ribosomal protein S17 Tcr_0304 231 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 78484739 Common - peptidyl-tRNA hydrolase Tcr_0394 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 78486382 Common - hydrogenase accessory protein HypB Tcr_2043 143 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 78486125 Common - putative signal transduction protein Tcr_1784 41 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 78485970 Common - glutamyl-tRNA(Gln) amidotransferase, C subunit Tcr_1629 141 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 78486032 Common - oxidoreductase FAD-binding region Tcr_1691 140 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 78485799 Common - N-acylneuraminate-9-phosphate synthase Tcr_1458 78 COG2089 SpsE, Sialic acid synthase Cell envelope biogenesis, outer membrane 78485740 Common - NusB antitermination factor Tcr_1396 188 COG0781 NusB, Transcription termination factor Transcription 78485155 Common - hypothetical protein Tcr_0810 57 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 78484978 Common - oligoribonuclease Tcr_0633 88 COG1949 Orn, Oligoribonuclease (3'->5' exoribonuclease) RNA processing and modification 78484934 Common - preprotein translocase, SecA subunit Tcr_0589 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 78484944 Common - dihydroxy-acid dehydratase Tcr_0599 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 78485987 Common - TniB Tcr_1646 37 COG1474 CDC6, Cdc6-related protein, AAA superfamily ATPase DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones 78486450 Nonpathogen - hypothetical protein Tcr_2112 3 COG3462 COG3462, Predicted membrane protein Function unknown 78485792 Common - Flagellar protein FlaG protein Tcr_1451 5 COG1334 FlaG, Uncharacterized flagellar protein FlaG Cell motility and secretion 78484688 Common obgE GTPase ObgE Tcr_0343 249 COG0536 Obg, Predicted GTPase General function prediction only 78485367 Common - tRNA 2-selenouridine synthase Tcr_1023 65 COG2603 COG2603, Predicted ATPase General function prediction only 78486362 Nonpathogen - ABC-type nitrate/sulfonate/bicarbonate transport systems periplasmic components-like Tcr_2023 10 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 78485942 Common - Glycosyl transferase, group 1 Tcr_1601 182 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 78484713 Nonpathogen - hypothetical protein Tcr_0368 1 None None None 78485161 Nonpathogen - preprotein translocase, SecG subunit Tcr_0816 3 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 78484502 Common - hypothetical protein Tcr_0157 27 None None None 78484754 Common - Phage integrase Tcr_0409 220 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 78486299 Common - Heavy metal translocating P-type ATPase Tcr_1960 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 78485871 Common - tryptophanyl-tRNA synthetase Tcr_1530 241 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 78485259 Common - argininosuccinate synthase Tcr_0914 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 78486029 Common - DegT/DnrJ/EryC1/StrS aminotransferase Tcr_1688 194 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 78484963 Common - HesB/YadR/YfhF Tcr_0618 164 COG0316 IscA, Uncharacterized conserved protein Function unknown 78485637 Common - Sodium:neurotransmitter symporter Tcr_1293 88 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 78484433 Common - Phage integrase Tcr_0088 20 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 78484532 Common trkA potassium transporter peripheral membrane component Tcr_0187 148 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 78485335 Common - ubiquinol-cytochrome c reductase, iron-sulfur subunit Tcr_0991 91 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 78484625 Common - Protein of unknown function DUF336 Tcr_0280 17 COG3193 GlcG, Uncharacterized protein, possibly involved in utilization of glycolate and propanediol General function prediction only 78484393 Common - GTP-binding protein, HSR1-related Tcr_0047 180 COG0218 COG0218, Predicted GTPase General function prediction only 78485473 Common - polynucleotide phosphorylase/polyadenylase Tcr_1129 242 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 78485499 Common - nitrate transport ATP-binding subunits C and D Tcr_1155 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 78485047 Common - protein tyrosine phosphatase Tcr_0702 142 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 78485658 Common - hypothetical protein Tcr_1314 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 78485233 Common - Short-chain dehydrogenase/reductase SDR Tcr_0888 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 78484663 Common - ribosomal protein S4 Tcr_0318 228 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 78486020 Common - NAD-dependent epimerase/dehydratase Tcr_1679 215 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 78485460 Common - acetyl-CoA synthetase Tcr_1116 216 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 78484550 Common - transcriptional regulator, LuxR family Tcr_0205 154 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 78485680 Common - hypothetical protein Tcr_1336 22 None None None 78485035 Common - Phage tail protein I Tcr_0690 28 COG4385 gpI, Bacteriophage P2-related tail formation protein General function prediction only 78485914 Common - Copper-resistance protein CopA Tcr_1573 119 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 78485706 Common - hypothetical protein Tcr_1362 10 None None None 78486356 Common - phosphoglucomutase Tcr_2017 231 COG0033 Pgm, Phosphoglucomutase Carbohydrate transport and metabolism 78484983 Nonpathogen - hypothetical protein Tcr_0638 1 None None None 78486274 Common - hypothetical protein Tcr_1935 23 COG3461 COG3461, Uncharacterized conserved protein Function unknown 78484584 Common - NAD-dependent epimerase/dehydratase Tcr_0239 128 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 78485852 Common - O-antigen polymerase Tcr_1511 3 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 78486093 Common - ErfK/YbiS/YcfS/YnhG Tcr_1752 28 COG3034 COG3034, Uncharacterized protein conserved in bacteria Function unknown 78485246 Common - ExsB Tcr_0901 176 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 78485225 Common - GreA/GreB family elongation factor Tcr_0880 204 COG0782 GreA, Transcription elongation factor Transcription 78486403 Common - TonB-dependent receptor Tcr_2064 115 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 78486226 Common - Aldehyde dehydrogenase Tcr_1887 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 78485975 Common - Rod shape-determining protein RodA Tcr_1634 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 78486440 Common - hypothetical protein Tcr_2102 20 None None None 78485392 Common - chromosomal replication initiator protein DnaA Tcr_1048 55 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 78484554 Common - hypothetical protein Tcr_0209 32 COG3672 COG3672, Predicted periplasmic protein Function unknown 78484522 Common - Ferritin and Dps Tcr_0177 85 COG1528 Ftn, Ferritin-like protein Inorganic ion transport and metabolism 78486499 Nonpathogen - hypothetical protein Tcr_2162 1 None None None 78485475 Nonpathogen - hypothetical protein Tcr_1131 1 None None None 78486510 Nonpathogen - hypothetical protein Tcr_2173 1 COG5336 COG5336, Uncharacterized protein conserved in bacteria Function unknown 78486475 Common - Guanylate kinase Tcr_2138 214 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 78486447 Common - hypothetical protein Tcr_2109 6 None None None 118139513 Common - Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Tcr_0784 223 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 78484741 Nonpathogen - Homoserine dehydrogenase, NAD-binding Tcr_0396 3 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 78485713 Common - Protein of unknown function DUF152 Tcr_1369 180 COG1496 COG1496, Uncharacterized conserved protein Function unknown 78485725 Common - sulfide-quinone reductase Tcr_1381 78 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 78486364 Common - Tellurite resistance protein TehB Tcr_2025 65 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 78485118 Common - hypothetical protein Tcr_0773 30 None None None 78485784 Common - flagellar hook-basal body complex protein (FliE) Tcr_1443 74 COG1677 FliE, Flagellar hook-basal body protein Cell motility and secretion / Intracellular trafficking and secretion 78485661 Nonpathogen - PepSY-associated TM helix Tcr_1317 4 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 78485582 Common - Protein of unknown function DUF615 Tcr_1238 61 COG3028 COG3028, Uncharacterized protein conserved in bacteria Function unknown 78486390 Common purU formyltetrahydrofolate deformylase Tcr_2051 217 COG0788 PurU, Formyltetrahydrofolate hydrolase Nucleotide transport and metabolism 78485177 Common - Phage integrase Tcr_0832 154 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 78486130 Common - putative transcriptional regulator, CopG family Tcr_1789 58 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 78484373 Common - methyl-accepting chemotaxis sensory transducer Tcr_0027 158 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 78484902 Common - hypothetical protein Tcr_0557 40 COG3216 COG3216, Uncharacterized protein conserved in bacteria Function unknown 78485029 Common - hypothetical protein Tcr_0684 4 None None None 78486468 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Tcr_2131 176 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 78485883 Common - Aminotransferase, class I and II Tcr_1542 237 COG1168 MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities Amino acid transport and metabolism 78484847 Common - Three-deoxy-D-manno-octulosonic-acid transferase-like Tcr_0502 128 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 78486164 Common - hypothetical protein Tcr_1823 199 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 78485997 Common - 4-hydroxythreonine-4-phosphate dehydrogenase Tcr_1656 159 COG1995 PdxA, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 78485348 Nonpathogen - hypothetical protein Tcr_1004 2 None None None 78485579 Common - asparaginase Tcr_1235 87 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 78485488 Common - Peptidase S49 Tcr_1144 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 78485298 Common - Rh-like protein/ammonium transporter Tcr_0954 203 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 78484675 Common - putative integrase Tcr_0330 15 COG4688 COG4688, Uncharacterized protein conserved in bacteria Function unknown 78486419 Common - Phosphonate uptake transporter Tcr_2081 138 COG3639 COG3639, ABC-type phosphate/phosphonate transport system, permease component Inorganic ion transport and metabolism 78486538 Common - Protein of unknown function DUF81 Tcr_2201 98 COG0730 COG0730, Predicted permeases General function prediction only 78486158 Common - hypothetical protein Tcr_1817 221 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 78485789 Common - flagellar protein FliS Tcr_1448 91 COG1516 FliS, Flagellin-specific chaperone FliS Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 78485166 Common - NADH-quinone oxidoreductase, E subunit Tcr_0821 155 COG1905 NuoE, NADH:ubiquinone oxidoreductase 24 kD subunit Energy production and conversion 78485570 Common - Ferritin and Dps Tcr_1226 139 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 78486073 Common - GHMP kinase Tcr_1732 43 COG1577 ERG12, Mevalonate kinase Lipid metabolism 78486203 Common - ferrochelatase Tcr_1864 170 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 78484757 Common - hypothetical protein Tcr_0412 79 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 78486397 Common - adenylate kinase Tcr_2058 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 78485399 Nonpathogen - hypothetical protein Tcr_1055 1 None None None 78485211 Common - DNA repair protein RecN Tcr_0866 214 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 78486267 Common - transcriptional regulator, ModE family Tcr_1928 65 COG2005 ModE, N-terminal domain of molybdenum-binding protein General function prediction only 78484496 Common - transferase hexapeptide repeat Tcr_0151 186 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 78484378 Common - ABC transporter related Tcr_0032 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 78484483 Nonpathogen - hypothetical protein Tcr_0138 1 None None None 78484829 Common - putative nicotinate-nucleotide adenylyltransferase Tcr_0484 187 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 78486519 Common - hypothetical protein Tcr_2182 3 None None None 78486195 Common - Protein of unknown function DUF302 Tcr_1854 20 COG3439 COG3439, Uncharacterized conserved protein Function unknown 78484950 Common - Peptidase M48, Ste24p Tcr_0605 130 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 78485905 Common - TonB-dependent receptor Tcr_1564 94 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 78484861 Nonpathogen - hypothetical protein Tcr_0516 5 None None None 78486232 Common - oxidoreductase FAD/NAD(P)-binding Tcr_1893 94 COG0369 CysJ, Sulfite reductase, alpha subunit (flavoprotein) Inorganic ion transport and metabolism 78486486 Common - Periplasmic solute binding protein Tcr_2149 161 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 78486323 Common - methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor Tcr_1984 175 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 78485376 Common - electron transport complex, RnfABCDGE type, G subunit Tcr_1032 60 COG4659 RnfG, Predicted NADH:ubiquinone oxidoreductase, subunit RnfG Energy production and conversion 78484628 Common - NusG antitermination factor Tcr_0283 216 COG0250 NusG, Transcription antiterminator Transcription 78484904 Common - methyltransferase Tcr_0559 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 78485849 Common - hypothetical protein Tcr_1508 33 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 78485126 Common - Cytochrome B561 Tcr_0781 49 COG3038 CybB, Cytochrome B561 Energy production and conversion 78486108 Nonpathogen - hypothetical protein Tcr_1767 3 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 78485572 Common - Pseudouridine synthase, Rsu Tcr_1228 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 78484642 Common - Ribosomal L23 protein Tcr_0297 215 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 78485314 Common - peptide chain release factor 3 Tcr_0970 249 COG4108 PrfC, Peptide chain release factor RF-3 Translation, ribosomal structure and biogenesis 78485218 Nonpathogen - hypothetical protein Tcr_0873 1 None None None 78485587 Common - transcriptional regulators, TraR/DksA family Tcr_1243 142 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 78485145 Common - Aspartate-semialdehyde dehydrogenase, USG-1 related Tcr_0800 236 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 78485190 Common - microcompartments protein Tcr_0845 46 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 78485868 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Tcr_1527 203 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 78484651 Common - ribosomal protein L24 Tcr_0306 211 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 78486173 Nonpathogen - hypothetical protein Tcr_1832 1 None None None 78484780 Common - Protein of unknown function DUF214 Tcr_0435 97 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 78484870 Common - hypothetical protein Tcr_0525 128 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 78485432 Common - ABC-type nitrate/sulfonate/bicarbonate transport systems periplasmic components-like Tcr_1088 92 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 78485812 Common - hypothetical protein Tcr_1471 126 COG1749 FlgE, Flagellar hook protein FlgE Cell motility and secretion 78485389 Common - phosphoribosylglycinamide formyltransferase Tcr_1045 221 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 78484959 Common - Inositol monophosphatase Tcr_0614 213 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 78485961 Common - phosphoserine phosphatase SerB Tcr_1620 149 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 78486120 Common - Secretion protein HlyD Tcr_1779 151 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 78486326 Common - primosomal protein N' (replication factor Y) Tcr_1987 213 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 78484833 Common - Patatin Tcr_0488 125 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 78485428 Common - DNA mismatch repair protein MutL Tcr_1084 191 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 78486205 Common - Major facilitator superfamily MFS_1 Tcr_1866 34 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 78485288 Common - Pseudouridine synthase, Rsu Tcr_0944 205 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 78486110 Nonpathogen - HPr kinase Tcr_1769 4 COG1493 HprK, Serine kinase of the HPr protein, regulates carbohydrate metabolism Signal transduction mechanisms 78485893 Common - dihydrodipicolinate synthase Tcr_1552 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 78485718 Common - succinyl-CoA synthetase, beta subunit Tcr_1374 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 78485926 Common - Protein of unknown function DUF481 Tcr_1585 35 COG3137 COG3137, Putative salt-induced outer membrane protein Cell envelope biogenesis, outer membrane 78486064 Common - type II secretion system protein Tcr_1723 71 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 78484614 Common - Indole-3-glycerol-phosphate synthase Tcr_0269 219 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 78486235 Common - putative phosphohistidine phosphatase, SixA Tcr_1896 79 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 78486256 Common - DNA repair protein RadC Tcr_1917 178 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 78486199 Common - Integrase, catalytic region Tcr_1859 143 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 78485647 Common - extracellular solute-binding protein, family 5 Tcr_1303 194 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 78485403 Nonpathogen - hypothetical protein Tcr_1059 1 None None None 78486115 Common - hypothetical protein Tcr_1774 13 COG3219 COG3219, Uncharacterized protein conserved in bacteria Function unknown 78485992 Common - hypothetical protein Tcr_1651 11 None None None 78485668 Common - Glycosyl hydrolase, BNR repeat Tcr_1324 5 None None None 78484893 Common - BolA-like protein Tcr_0548 88 COG0271 BolA, Stress-induced morphogen (activity unknown) Signal transduction mechanisms 78486129 Common - ABC transporter related Tcr_1788 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 78486476 Common - DegT/DnrJ/EryC1/StrS aminotransferase Tcr_2139 194 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 78484898 Common - methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor Tcr_0553 165 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 78485520 Common - trigger factor Tcr_1176 216 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 78485508 Common - septum site-determining protein MinC Tcr_1164 108 COG0850 MinC, Septum formation inhibitor Cell division and chromosome partitioning 78484382 Common - ribosome-associated GTPase Tcr_0036 163 COG1162 COG1162, Predicted GTPases General function prediction only 78485291 Common - Band 7 protein Tcr_0947 220 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 78485131 Common - transcriptional regulator, BadM/Rrf2 family Tcr_0786 148 COG1959 COG1959, Predicted transcriptional regulator Transcription 78486333 Common - TonB-dependent receptor Tcr_1994 110 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 78485736 Common - hypothetical protein Tcr_1392 19 None None None 78484796 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Tcr_0451 230 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 78485620 Common - UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase Tcr_1276 159 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 78485777 Common - methyl-accepting chemotaxis sensory transducer Tcr_1436 146 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 78485409 Common - ATPase, E1-E2 type Tcr_1065 232 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 78485017 Common - Phage terminase GpA Tcr_0672 37 COG5525 COG5525, Bacteriophage tail assembly protein General function prediction only 78485332 Common hisG ATP phosphoribosyltransferase catalytic subunit Tcr_0988 211 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 78486337 Common - integral membrane protein Tcr_1998 37 COG5473 COG5473, Predicted integral membrane protein Function unknown 78484453 Common - adenine phosphoribosyltransferase Tcr_0108 170 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 78486483 Common - ABC-3 Tcr_2146 169 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 78486437 Common - putative ORF1 (plasmid pTOM9) Tcr_2099 28 None None None 78485932 Common - Regulatory protein RecX Tcr_1591 64 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 78485562 Nonpathogen - SlyX Tcr_1218 1 COG2900 SlyX, Uncharacterized protein conserved in bacteria Function unknown 78484359 Common - Phosphoribulokinase Tcr_0013 57 COG3954 PrkB, Phosphoribulokinase Energy production and conversion 78484949 Common - Cytochrome c, class I Tcr_0604 12 None None None 78484402 Common - Secretion protein HlyD Tcr_0056 164 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 78484707 Common - uracil-DNA glycosylase Tcr_0362 129 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 78485207 Common - GCN5-related N-acetyltransferase Tcr_0862 3 None None None 78486119 Common - Heavy metal efflux pump CzcA Tcr_1778 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 78484463 Common - AsmA Tcr_0118 52 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 78486036 Common - hypothetical protein Tcr_1695 59 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 78484561 Common - Pseudouridylate synthase Tcr_0216 84 COG0585 COG0585, Uncharacterized conserved protein Function unknown 78484819 Common - PhoH-like protein Tcr_0474 199 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 78485325 Common - Mammalian cell entry related Tcr_0981 101 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 78485011 Nonpathogen - hypothetical protein Tcr_0666 4 None None None 78484787 Common - ribosomal protein L11 methyltransferase Tcr_0442 178 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 78486421 Common phnH carbon-phosphorus lyase complex subunit Tcr_2083 32 COG3625 PhnH, Uncharacterized enzyme of phosphonate metabolism Inorganic ion transport and metabolism 78485086 Common - flagellar biosynthetic protein FliQ Tcr_0741 87 COG1987 FliQ, Flagellar biosynthesis pathway, component FliQ Cell motility and secretion / Intracellular trafficking and secretion 78486045 Common - Secretion protein HlyD Tcr_1704 148 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 78484658 Common - ribosomal protein L30 Tcr_0313 110 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 78485617 Common - lipid-A-disaccharide synthase Tcr_1273 139 COG0763 LpxB, Lipid A disaccharide synthetase Cell envelope biogenesis, outer membrane 78484507 Common - molybdenum cofactor biosynthesis protein C Tcr_0162 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 78486078 Common - Glycosyl transferase, family 2 Tcr_1737 154 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 78485861 Common - lipid A biosynthesis acyltransferase Tcr_1520 110 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 78486214 Common - Protein of unknown function DUF198 Tcr_1875 77 COG1469 COG1469, Uncharacterized conserved protein Function unknown 78485659 Common - conserved hypothetical signal peptide protein Tcr_1315 20 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 78486072 Common - Protein of unknown function DUF336 Tcr_1731 49 COG3193 GlcG, Uncharacterized protein, possibly involved in utilization of glycolate and propanediol General function prediction only 78484837 Common - ribosomal protein S20 Tcr_0492 197 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 78484477 Nonpathogen - YfaZ Tcr_0132 5 None None None 78486046 Common - HEAT Tcr_1705 38 COG4335 COG4335, DNA alkylation repair enzyme DNA replication, recombination, and repair 78486202 Common - Protein of unknown function DUF523 Tcr_1863 65 COG3272 COG3272, Uncharacterized conserved protein Function unknown 78485532 Common - Short-chain dehydrogenase/reductase SDR Tcr_1188 123 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 78485280 Common - Mg2+ transporter protein, CorA-like Tcr_0935 78 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 78484575 Common - hypothetical protein Tcr_0230 11 None None None 78486281 Common - signal recognition particle-docking protein FtsY Tcr_1942 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 78486008 Common - threonyl-tRNA synthetase Tcr_1667 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 78485722 Nonpathogen - hypothetical protein Tcr_1378 1 None None None 78485855 Common - Capsule polysaccharide biosynthesis Tcr_1514 15 COG3562 KpsS, Capsule polysaccharide export protein Cell envelope biogenesis, outer membrane 78485734 Common - anti-sigma-factor antagonist (STAS) domain protein Tcr_1390 13 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 78484446 Nonpathogen - hypothetical protein Tcr_0101 1 None None None 78484528 Common - lipid A biosynthesis acyltransferase Tcr_0183 99 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 78486117 Nonpathogen - hypothetical protein Tcr_1776 1 COG3767 COG3767, Uncharacterized low-complexity protein Function unknown 78485884 Common - Protein of unknown function DUF323 Tcr_1543 83 COG1262 COG1262, Uncharacterized conserved protein Function unknown 78485197 Common - transcriptional regulator, LysR family Tcr_0852 192 COG0583 LysR, Transcriptional regulator Transcription 78486480 Common - DNA-directed RNA polymerase, omega subunit Tcr_2143 116 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 78486220 Common - hypothetical protein Tcr_1881 92 COG0628 PerM, Predicted permease General function prediction only 78485705 Common - ribosomal protein L9 Tcr_1361 213 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 78485504 Common - uroporphyrin-III C-methyltransferase Tcr_1160 204 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 78485643 Common - Binding-protein-dependent transport systems inner membrane component Tcr_1299 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 78485309 Common - Rhodanese-like Tcr_0965 146 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 78485245 Common - TPR repeat domain protein Tcr_0900 97 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 78485300 Common - hypothetical protein Tcr_0956 49 COG3216 COG3216, Uncharacterized protein conserved in bacteria Function unknown 78484377 Common - hypothetical protein Tcr_0031 17 None None None 78484571 Common - multi-sensor hybrid histidine kinase Tcr_0226 222 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 78485575 Common - PHP-like Tcr_1231 126 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 78485334 Common - Protein of unknown function DUF34 Tcr_0990 100 COG0327 COG0327, Uncharacterized conserved protein Function unknown 78485405 Common - Protein of unknown function DUF808 Tcr_1061 60 COG2354 COG2354, Uncharacterized protein conserved in bacteria Function unknown 78485750 Common - SmpA/OmlA Tcr_1406 36 COG2913 SmpA, Small protein A (tmRNA-binding) Translation, ribosomal structure and biogenesis 78485717 Common - succinyl-CoA synthetase, alpha subunit Tcr_1373 215 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 78486234 Common pyrE orotate phosphoribosyltransferase Tcr_1895 150 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 78485618 Common - acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase Tcr_1274 161 COG1043 LpxA, Acyl- acyl carrier protein 78484587 Common - Secretion protein HlyD Tcr_0242 149 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 78485082 Common - pyridoxal phosphate biosynthetic protein PdxJ Tcr_0737 139 COG0854 PdxJ, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 78485500 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Tcr_1156 216 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 78485521 Common clpP ATP-dependent Clp protease proteolytic subunit Tcr_1177 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 78486347 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) Tcr_2008 174 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 78485147 Common - Phosphoribosylanthranilate isomerase Tcr_0802 193 COG0135 TrpF, Phosphoribosylanthranilate isomerase Amino acid transport and metabolism 78485819 Common - anti-sigma-28 factor, FlgM Tcr_1478 12 COG2747 FlgM, Negative regulator of flagellin synthesis (anti-sigma28 factor) Transcription / Cell motility and secretion / Intracellular trafficking and secretion 78485601 Common - stationary-phase survival protein SurE Tcr_1257 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 78485963 Common - MotA/TolQ/ExbB proton channel Tcr_1622 18 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 78484641 Common - Ribosomal protein L4/L1e Tcr_0296 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 78486363 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Tcr_2024 179 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 78485031 Nonpathogen - hypothetical protein Tcr_0686 1 None None None 78486319 Common - Alpha/beta hydrolase fold Tcr_1980 44 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 78485626 Common - ribosome recycling factor Tcr_1282 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 78484843 Common - Lytic murein transglycosylase Tcr_0498 102 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 78486187 Common - Carboxylesterase Tcr_1846 82 COG0400 COG0400, Predicted esterase General function prediction only 78484894 Common - Arylesterase Tcr_0549 101 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 78485016 Nonpathogen - hypothetical protein Tcr_0671 3 None None None 78485119 Common - Alpha amylase, catalytic region Tcr_0774 131 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 78486062 Nonpathogen - hypothetical protein Tcr_1721 1 None None None 78484799 Common - Secretion protein HlyD Tcr_0454 170 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 78485075 Common - positive regulator of sigma(E), RseC/MucC Tcr_0730 30 COG3086 RseC, Positive regulator of sigma E activity Signal transduction mechanisms 78485400 Nonpathogen - hypothetical protein Tcr_1056 1 None None None 78486212 Common - FAD dependent oxidoreductase Tcr_1873 67 COG0579 COG0579, Predicted dehydrogenase General function prediction only 78484465 Common - A/G-specific adenine glycosylase Tcr_0120 235 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 78486113 Common - ribonuclease BN, putative Tcr_1772 74 COG1295 Rbn, Predicted membrane protein Function unknown 78485198 Common - NADH dehydrogenase subunit L Tcr_0853 202 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 78485608 Common - acetyl-CoA carboxylase, carboxyl transferase, alpha subunit Tcr_1264 199 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 78486474 Common - Shikimate kinase Tcr_2137 202 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 78485295 Nonpathogen - hypothetical protein Tcr_0951 2 None None None 78485865 Common - MotA/TolQ/ExbB proton channel Tcr_1524 93 COG1291 MotA, Flagellar motor component Cell motility and secretion 78486182 Common - ferrous iron transport protein B Tcr_1841 197 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 78485672 Common - Pseudouridine synthase RluA-like Tcr_1328 214 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 78484971 Common - hypothetical protein Tcr_0626 201 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 78486171 Common - dihydroorotase, multifunctional complex type Tcr_1830 211 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 78485585 Common - Carbohydrate kinase, FGGY Tcr_1241 111 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 78486511 Common - parB-like partition proteins Tcr_2174 186 COG1475 Spo0J, Predicted transcriptional regulators Transcription 78486071 Nonpathogen - hypothetical protein Tcr_1730 1 None None None 78486259 Common - diguanylate cyclase (GGDEF domain) with PAS/PAC sensor Tcr_1920 207 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 78485702 Common - Nucleoside diphosphate pyrophosphatase Tcr_1358 106 COG2816 NPY1, NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding DNA replication, recombination, and repair 78484855 Common - 4-alpha-glucanotransferase Tcr_0510 120 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 78484763 Common - hypothetical protein Tcr_0418 8 None None None 78486204 Common - short chain dehydrogenase Tcr_1865 206 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 78484389 Common - homoserine kinase Tcr_0043 62 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 78486376 Common - Nickel-dependent hydrogenase, large subunit Tcr_2037 97 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 78484752 Common - Bile acid:sodium symporter Tcr_0407 94 COG0385 COG0385, Predicted Na+-dependent transporter General function prediction only 78485666 Common - hypothetical protein Tcr_1322 13 None None None 78485729 Common - thioredoxin Tcr_1385 232 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 78485822 Nonpathogen - hypothetical protein Tcr_1481 1 None None None 78486091 Common - twitching motility protein Tcr_1750 213 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 78485972 Common - rod shape-determining protein MreC Tcr_1631 150 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 78484372 Common - hypothetical protein Tcr_0026 14 None None None 78486098 Common - HAD-superfamily hydrolase subfamily IA, variant 3 Tcr_1757 46 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 78485903 Common - 5-formyltetrahydrofolate cyclo-ligase Tcr_1562 168 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 78485055 Common - 3-oxoacyl-(acyl-carrier-protein) synthase III Tcr_0710 209 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 78484485 Common - Glutathione reductase Tcr_0140 242 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 78486079 Common - ClpXP protease specificity-enhancing factor Tcr_1738 64 COG2969 SspB, Stringent starvation protein B General function prediction only 78486136 Common - HAD-superfamily hydrolase subfamily IIB Tcr_1795 32 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 78484426 Common - Lytic transglycosylase, catalytic Tcr_0080 116 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 78485057 Common - 3-oxoacyl-(acyl-carrier-protein) reductase Tcr_0712 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 78485106 Common - hypothetical protein Tcr_0761 53 COG3323 COG3323, Uncharacterized protein conserved in bacteria Function unknown 78485675 Common - protein-export membrane protein SecD Tcr_1331 220 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 78486161 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Tcr_1820 170 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 78485264 Common - UDP-2,3-diacylglucosamine hydrolase Tcr_0919 79 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 78484926 Common - FeS assembly protein SufD Tcr_0581 174 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 78485580 Common - Protein of unknown function DUF6, transmembrane Tcr_1236 150 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 78485174 Common - proton-translocating NADH-quinone oxidoreductase, chain M Tcr_0829 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 78485931 Common - alanyl-tRNA synthetase Tcr_1590 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 78484960 Common - RNA methyltransferase TrmH, group 1 Tcr_0615 161 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 78485991 Common - Protein of unknown function DUF328 Tcr_1650 82 COG3022 COG3022, Uncharacterized protein conserved in bacteria Function unknown 78484616 Common - hypothetical protein Tcr_0271 16 COG3271 COG3271, Predicted double-glycine peptidase General function prediction only 78485157 Common - ATP-dependent metalloprotease FtsH Tcr_0812 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 78486500 Common - UDP-N-acetylglucosamine pyrophosphorylase Tcr_2163 236 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 78485114 Common - response regulator receiver (CheY-like) and ANTAR domain protein Tcr_0769 92 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 78485564 Common - hypothetical protein Tcr_1220 13 None None None 78486271 Common - hypothetical protein Tcr_1932 210 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 78484989 Nonpathogen - hypothetical protein Tcr_0644 1 None None None 78486496 Nonpathogen - Phosphate-selective porin O and P Tcr_2159 3 None None None 78485375 Common - SoxR-reducing system protein RsxE Tcr_1031 76 COG4660 RnfE, Predicted NADH:ubiquinone oxidoreductase, subunit RnfE Energy production and conversion 78485682 Common - transcriptional regulator, XRE family Tcr_1338 125 COG1396 HipB, Predicted transcriptional regulators Transcription 78486154 Nonpathogen - hypothetical protein Tcr_1813 1 None None None 78486344 Nonpathogen - hypothetical protein Tcr_2005 12 COG1416 COG1416, Uncharacterized conserved protein Function unknown 78485318 Common - OstA-like protein Tcr_0974 59 COG1934 COG1934, Uncharacterized protein conserved in bacteria Function unknown 78484511 Common - response regulator receiver (CheY-like) modulated diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Tcr_0166 223 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 78485180 Nonpathogen - hypothetical protein Tcr_0835 5 None None None 78486301 Common - 4Fe-4S ferredoxin, iron-sulfur binding Tcr_1962 77 COG0348 NapH, Polyferredoxin Energy production and conversion 78486105 Nonpathogen - Phosphoglycerate/bisphosphoglycerate mutase Tcr_1764 2 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 78486247 Common - Amino acid permease-associated region Tcr_1908 175 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 78485851 Common - UDP-glucose/GDP-mannose dehydrogenase Tcr_1510 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 78485940 Common - diacylglycerol kinase Tcr_1599 64 COG0818 DgkA, Diacylglycerol kinase Cell envelope biogenesis, outer membrane 78485442 Common - hypothetical protein Tcr_1098 41 COG2915 COG2915, Uncharacterized protein involved in purine metabolism General function prediction only 78484381 Common - transcriptional regulator, NifA subfamily, Fis Family Tcr_0035 169 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 78484900 Nonpathogen - putative signal transduction protein Tcr_0555 7 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 78485526 Common - extracellular solute-binding protein, family 5 Tcr_1182 155 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 78486191 Common - glycine cleavage system H protein Tcr_1850 187 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 78486515 Nonpathogen - hypothetical protein Tcr_2178 1 None None None 78484885 Common - phosphate uptake regulator, PhoU Tcr_0540 160 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 78486439 Common - transcriptional regulator, ArsR family Tcr_2101 93 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 78485486 Common - bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase Tcr_1142 218 COG1049 AcnB, Aconitase B Energy production and conversion 78484962 Common - transcriptional regulator, BadM/Rrf2 family Tcr_0617 176 COG1959 COG1959, Predicted transcriptional regulator Transcription 78485782 Common - flagellar motor switch protein FliG Tcr_1441 125 COG1536 FliG, Flagellar motor switch protein Cell motility and secretion 78484671 Common - Major facilitator superfamily MFS_1 Tcr_0326 229 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 78485253 Nonpathogen - hypothetical protein Tcr_0908 3 None None None 78484732 Common - UBA/THIF-type NAD/FAD binding fold protein Tcr_0387 223 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 78484680 Nonpathogen - hypothetical protein Tcr_0335 3 None None None 78485346 Common - Catalytic domain of components of various dehydrogenase complexes Tcr_1002 196 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 78485022 Nonpathogen - hypothetical protein Tcr_0677 1 None None None 78485116 Common - hypothetical protein Tcr_0771 8 None None None 78484611 Common - anthranilate synthase component I Tcr_0266 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 78484661 Common rpsM 30S ribosomal protein S13 Tcr_0316 243 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 78486392 Common - oxidoreductase FAD/NAD(P)-binding Tcr_2053 133 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 78484917 Common - Thymidylate synthase Tcr_0572 137 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 78485858 Common - ADP-L-glycero-D-manno-heptose-6-epimerase Tcr_1517 227 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 78486206 Common - Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) Tcr_1867 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 78485151 Common - FolC bifunctional protein Tcr_0806 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 78486022 Common - Glycosyl transferase, group 1 Tcr_1681 126 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 78484349 Common - DNA replication and repair protein RecF Tcr_0003 164 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 78486284 Common - Beta-ketoacyl synthase Tcr_1945 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 78484692 Common - Glutathione S-transferase-like Tcr_0347 36 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 78484500 Nonpathogen - hypothetical protein Tcr_0155 2 None None None 78484534 Common - periplasmic sensor signal transduction histidine kinase Tcr_0189 223 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 78486349 Common - putative methyl-accepting chemotaxis protein (McpB) Tcr_2010 12 None None None 78485634 Common - hypothetical protein Tcr_1290 110 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 78485774 Common - Flagellar basal body-associated protein FliL Tcr_1433 9 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 78485749 Common - ferric uptake regulator, FUR family Tcr_1405 188 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 78486031 Common - Nucleotidyl transferase Tcr_1690 165 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 78485768 Common - outer membrane protein, probably efflux family Tcr_1426 11 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 78484946 Common - sulfur oxidation protein SoxA Tcr_0601 27 COG3258 COG3258, Cytochrome c Energy production and conversion 78484365 Common - SUA5/yciO/yrdC-like Tcr_0019 229 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 78484653 Common - Ribosomal protein S14 Tcr_0308 210 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 78485523 Common - ATP-dependent protease La Tcr_1179 230 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 78485350 Common - hypothetical protein Tcr_1006 42 COG3530 COG3530, Uncharacterized protein conserved in bacteria Function unknown 78486314 Common - Protein of unknown function DUF255 Tcr_1975 105 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 78485977 Common - Aminotransferase, class IV Tcr_1636 196 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 78485797 Common - Nucleotidyl transferase Tcr_1456 169 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 78485158 Common - dihydropteroate synthase Tcr_0813 218 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 78485790 Common - Flagellar hook-associated 2-like Tcr_1449 117 COG1345 FliD, Flagellar capping protein Cell motility and secretion 78484581 Nonpathogen - hypothetical protein Tcr_0236 12 None None None 78485236 Common - quinolinate synthetase Tcr_0891 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 78485387 Common dcd deoxycytidine triphosphate deaminase Tcr_1043 150 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 78484594 Common - hypothetical protein Tcr_0249 14 COG3031 PulC, Type II secretory pathway, component PulC Intracellular trafficking and secretion 78485924 Common - 6-phosphofructokinase Tcr_1583 139 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 78486424 Common - ABC transporter related Tcr_2086 249 COG4107 PhnK, ABC-type phosphonate transport system, ATPase component Inorganic ion transport and metabolism 78485630 Common - methionine aminopeptidase, type I Tcr_1286 243 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 78486134 Common - Amidase Tcr_1793 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 78484957 Nonpathogen - hypothetical protein Tcr_0612 1 None None None 78484744 Common - Xanthine/uracil/vitamin C permease Tcr_0399 134 COG2252 COG2252, Permeases General function prediction only 78485440 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Tcr_1096 172 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 78484841 Common - lipoprotein signal peptidase Tcr_0496 204 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 78485133 Common - transcriptional regulator, BadM/Rrf2 family Tcr_0788 154 COG1959 COG1959, Predicted transcriptional regulator Transcription 78485088 Common - flagellar biosynthetic protein FlhB Tcr_0743 130 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 78486459 Common - Phage integrase Tcr_2121 103 COG0582 XerC, Integrase DNA replication, recombination, and repair 78484906 Nonpathogen - Cell division protein, FtsL -like Tcr_0561 1 COG3116 FtsL, Cell division protein Cell division and chromosome partitioning 78485801 Common - transferase hexapeptide repeat Tcr_1460 172 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 78484931 Common - Cell division protein FtsQ Tcr_0586 75 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 78486387 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Tcr_2048 179 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 78485209 Common - hypothetical protein Tcr_0864 32 COG3211 PhoX, Predicted phosphatase General function prediction only 78485038 Common - Protein of unknown function DUF1353 Tcr_0693 8 None None None 78485695 Common - FAD dependent oxidoreductase Tcr_1351 125 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 78485597 Common - Protein of unknown function DUF598 Tcr_1253 40 COG3737 COG3737, Uncharacterized conserved protein Function unknown 78485213 Common - negative regulator of class I heat shock protein Tcr_0868 148 COG1420 HrcA, Transcriptional regulator of heat shock gene Transcription 78485033 Common - phage protein gp25 Tcr_0688 15 COG3628 COG3628, Phage baseplate assembly protein W General function prediction only 78485945 Nonpathogen - Protein of unknown function DUF6, transmembrane Tcr_1604 8 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 78485741 Common - Riboflavin synthase Tcr_1397 230 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 78485873 Common - Hydrophobe/amphiphile efflux-1 HAE1 Tcr_1532 184 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 78485006 Nonpathogen - hypothetical protein Tcr_0661 1 None None None 78486525 Nonpathogen - hypothetical protein Tcr_2188 1 None None None 78484769 Common - Ribulose-bisphosphate carboxylase Tcr_0424 67 COG1850 RbcL, Ribulose 1,5-bisphosphate carboxylase, large subunit Carbohydrate transport and metabolism 78485364 Common - Acyl-CoA dehydrogenase-like Tcr_1020 49 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 78484995 Common rplS 50S ribosomal protein L19 Tcr_0650 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 78484694 Common - HesB/YadR/YfhF Tcr_0349 166 COG0316 IscA, Uncharacterized conserved protein Function unknown 78485986 Common - hypothetical protein Tcr_1645 16 None None None 78484858 Common - Glycogen/starch/alpha-glucan phosphorylase Tcr_0513 137 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 78485847 Common - ribonuclease, Rne/Rng family Tcr_1506 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 78486505 Common - ATP synthase F1, delta subunit Tcr_2168 184 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 78485761 Common - transcriptional regulator, AsnC family Tcr_1418 158 COG1522 Lrp, Transcriptional regulators Transcription 78485103 Common - response regulator receiver (CheY-like) modulated CheB methylesterase Tcr_0758 216 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 78484760 Common - hypothetical protein Tcr_0415 7 None None None 78484719 Common - hypothetical protein Tcr_0374 15 None None None 78486417 Common - Phosphonate-binding periplasmic protein Tcr_2079 94 COG3221 PhnD, ABC-type phosphate/phosphonate transport system, periplasmic component Inorganic ion transport and metabolism 78484853 Common - Glucose-1-phosphate adenylyltransferase Tcr_0508 180 COG0448 GlgC, ADP-glucose pyrophosphorylase Carbohydrate transport and metabolism 78485691 Common - Glutamate--ammonia ligase Tcr_1347 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 78485041 Common - hypothetical protein Tcr_0696 5 COG3498 COG3498, Phage tail tube protein FII General function prediction only 78486358 Common - hypothetical protein Tcr_2019 110 COG0397 COG0397, Uncharacterized conserved protein Function unknown 78484705 Common - OmpA/MotB Tcr_0360 99 COG1360 MotB, Flagellar motor protein Cell motility and secretion 78484775 Common - von Willebrand factor, type A Tcr_0430 45 COG4548 NorD, Nitric oxide reductase activation protein Inorganic ion transport and metabolism 78486148 Common - DNA primase Tcr_1807 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 78486100 Common - thioredoxin, putative Tcr_1759 115 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 78484631 Common - Ribosomal protein L10 Tcr_0286 212 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 78485463 Common - putative signal-transduction protein with CBS domains Tcr_1119 68 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 78486145 Common - Fatty acid desaturase Tcr_1804 4 COG3239 DesA, Fatty acid desaturase Lipid metabolism 78485140 Common - isopropylmalate isomerase large subunit Tcr_0795 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 78486524 Common - two component, sigma54 specific, transcriptional regulator, Fis family Tcr_2187 223 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 78486012 Common - Protein-L-isoaspartate(D-aspartate) O-methyltransferase Tcr_1671 160 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 78486446 Common - amino acid permease-associated region Tcr_2108 130 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 78485491 Nonpathogen - hypothetical protein Tcr_1147 1 None None None 78485953 Common - CheA signal transduction histidine kinase Tcr_1612 155 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 78486401 Common - Succinylglutamate desuccinylase/aspartoacylase Tcr_2062 54 COG3608 COG3608, Predicted deacylase General function prediction only 78484872 Common - NADH:flavin oxidoreductase/NADH oxidase Tcr_0527 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 78485808 Common flgI flagellar basal body P-ring protein Tcr_1467 106 COG1706 FlgI, Flagellar basal-body P-ring protein Cell motility and secretion 78484436 Nonpathogen - hypothetical protein Tcr_0091 3 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 78484783 Common - phosphoribosylamine--glycine ligase Tcr_0438 232 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 78485091 Common - Cobyrinic acid a,c-diamide synthase Tcr_0746 241 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 78484391 Common - hypothetical protein Tcr_0045 6 None None None 78485515 Common - hypothetical protein Tcr_1171 133 COG2860 COG2860, Predicted membrane protein Function unknown 78484497 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) Tcr_0152 182 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 78484880 Common - hypothetical protein Tcr_0535 27 COG4391 COG4391, Uncharacterized protein conserved in bacteria Function unknown 78485912 Common - Protein of unknown function DUF462 Tcr_1571 31 COG3101 COG3101, Uncharacterized protein conserved in bacteria Function unknown 78485541 Common - cytidylate kinase Tcr_1197 204 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 78485183 Common rbcL ribulose bisophosphate carboxylase Tcr_0838 67 COG1850 RbcL, Ribulose 1,5-bisphosphate carboxylase, large subunit Carbohydrate transport and metabolism 78486068 Common - type II and III secretion system protein Tcr_1727 142 COG4964 CpaC, Flp pilus assembly protein, secretin CpaC Intracellular trafficking and secretion 78484545 Common - diguanylate cyclase (GGDEF domain) Tcr_0200 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 78484878 Common - acetylornithine and succinylornithine aminotransferase Tcr_0533 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 78485273 Common - Ribonuclease H Tcr_0928 170 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 78484636 Common - 30S ribosomal protein S7 Tcr_0291 242 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 78485062 Common - Aminodeoxychorismate lyase Tcr_0717 185 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 78485707 Common - ribosomal protein S18 Tcr_1363 215 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 78484747 Common - ubiquinone/menaquinone biosynthesis methyltransferase Tcr_0402 216 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 78485534 Common - 3-demethylubiquinone-9 3-methyltransferase Tcr_1190 164 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 78485417 Common - Abortive infection protein Tcr_1073 28 None None None 78484939 Common - Dephospho-CoA kinase Tcr_0594 211 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 78484418 Common - TPR repeat domain protein Tcr_0072 44 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 78486339 Common - Acriflavin resistance protein Tcr_2000 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 78484470 Common - ribosomal protein L31 Tcr_0125 175 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 78485084 Common - Flagellar biosynthesis protein, FliO Tcr_0739 4 COG3190 FliO, Flagellar biogenesis protein Cell motility and secretion 78486425 Common - ABC transporter related Tcr_2087 249 COG4778 PhnL, ABC-type phosphonate transport system, ATPase component Inorganic ion transport and metabolism 78485136 Nonpathogen - hypothetical protein Tcr_0791 1 None None None 78484824 Common - leucyl-tRNA synthetase Tcr_0479 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 78484973 Common - Cytochrome c, class I Tcr_0628 64 COG2863 COG2863, Cytochrome c553 Energy production and conversion 78486315 Common - hypothetical protein Tcr_1976 42 COG2738 COG2738, Predicted Zn-dependent protease General function prediction only 78485537 Common - Chorismate mutase Tcr_1193 213 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 78486294 Common - Rhodanese-like Tcr_1955 158 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 78486006 Common rpmI 50S ribosomal protein L35 Tcr_1665 181 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 78485624 Common - Phosphatidate cytidylyltransferase Tcr_1280 215 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 78485053 Common rpmF 50S ribosomal protein L32 Tcr_0708 105 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 78485530 Common - phosphoenolpyruvate synthase Tcr_1186 235 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 78485320 Common - phosphatase kdsC Tcr_0976 102 COG1778 COG1778, Low specificity phosphatase (HAD superfamily) General function prediction only 78485195 Common - Ham1-like protein Tcr_0850 228 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 78485509 Common - septum site-determining protein MinD Tcr_1165 147 COG2894 MinD, Septum formation inhibitor-activating ATPase Cell division and chromosome partitioning 78485906 Common - Electron transport protein SCO1/SenC Tcr_1565 104 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 78486111 Common - hypothetical protein Tcr_1770 6 None None None 78484513 Common - proline iminopeptidase Tcr_0168 118 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 78485502 Common - putative nitrate reductase (electron transfer subunit) AND putative nitrite reductase (small subunit) Tcr_1158 45 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 78486121 Common - DJ-1 Tcr_1780 157 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 78484955 Common - CDP-diacylglycerol--serine O-phosphatidyltransferase Tcr_0610 152 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 78484948 Common - Sulfur oxidation protein SoxY-like Tcr_0603 37 COG5501 COG5501, Predicted secreted protein Function unknown 78485929 Common - carbon storage regulator, CsrA Tcr_1588 82 COG1551 CsrA, Carbon storage regulator (could also regulate swarming and quorum sensing) Signal transduction mechanisms 78486308 Common - imidazoleglycerol phosphate synthase, cyclase subunit Tcr_1969 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 78486472 Common - Aldose 1-epimerase Tcr_2135 63 COG0676 COG0676, Uncharacterized enzymes related to aldose 1-epimerase Carbohydrate transport and metabolism 78485843 Common - Flagellin-like Tcr_1502 106 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 78484793 Common - NAD-dependent epimerase/dehydratase Tcr_0448 73 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 78486103 Nonpathogen - hypothetical protein Tcr_1762 1 None None None 78486001 Common - transcriptional regulator, MerR family Tcr_1660 91 COG0789 SoxR, Predicted transcriptional regulators Transcription 78485833 Common - Lytic transglycosylase, catalytic Tcr_1492 140 COG4623 COG4623, Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein Cell envelope biogenesis, outer membrane 78485283 Nonpathogen - hypothetical protein Tcr_0939 1 None None None 78485293 Common - Protein of unknown function DUF302 Tcr_0949 34 COG3439 COG3439, Uncharacterized conserved protein Function unknown 78485384 Common - response regulator receiver sensor signal transduction histidine kinase Tcr_1040 85 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 78485863 Common - aspartate alpha-decarboxylase Tcr_1522 130 COG0853 PanD, Aspartate 1-decarboxylase Coenzyme metabolism 78484896 Common - Protein of unknown function DUF214 Tcr_0551 85 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 78485124 Common - DEAD/DEAH box helicase-like Tcr_0779 235 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 78485064 Common - DNA-directed DNA polymerase Tcr_0719 216 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 78485220 Common - Class I peptide chain release factor Tcr_0875 109 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 78485965 Common - TonB-like Tcr_1624 13 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 78485149 Common - tryptophan synthase, alpha subunit Tcr_0804 216 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 78484467 Common - diguanylate phosphodiesterase (EAL domain) Tcr_0122 83 COG3434 COG3434, Predicted signal transduction protein containing EAL and modified HD-GYP domains Signal transduction mechanisms 78484408 Common - NADH-ubiquinone oxidoreductase, chain 4L Tcr_0062 88 COG1006 MnhC, Multisubunit Na+/H+ antiporter, MnhC subunit Inorganic ion transport and metabolism 78484577 Common - hypothetical protein Tcr_0232 100 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 78486291 Common - Glycerol-3-phosphate dehydrogenase (NAD(P)+) Tcr_1952 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 78484820 Common - hypothetical protein Tcr_0475 203 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 78484835 Nonpathogen - hypothetical protein Tcr_0490 1 None None None 78485336 Common - Cytochrome b/b6-like Tcr_0992 148 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 78486283 Common - hypothetical protein Tcr_1944 38 COG4764 COG4764, Uncharacterized protein conserved in bacteria Function unknown 78484505 Common - Molybdopterin biosynthesis MoaE Tcr_0160 157 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 78484421 Common - Protein of unknown function DUF58 Tcr_0075 98 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 78485566 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) Tcr_1222 192 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 78484526 Common - MOSC Tcr_0181 81 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 78486493 Common - sigma-24 (FecI-like) Tcr_2156 165 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 78485165 Common - NADH dehydrogenase subunit D Tcr_0820 191 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 78485436 Common - hypothetical protein Tcr_1092 19 COG3242 COG3242, Uncharacterized protein conserved in bacteria Function unknown 78486513 Common - methyltransferase GidB Tcr_2176 143 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 78484758 Common - Protein of unknown function DUF218 Tcr_0413 77 COG1434 COG1434, Uncharacterized conserved protein Function unknown 78484703 Common - MotA/TolQ/ExbB proton channel Tcr_0358 83 COG1291 MotA, Flagellar motor component Cell motility and secretion 78484646 Common - ribosomal protein S3 Tcr_0301 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 78486077 Nonpathogen - hypothetical protein Tcr_1736 1 None None None 78485326 Common - Toluene tolerance Tcr_0982 78 COG2854 Ttg2D, ABC-type transport system involved in resistance to organic solvents, auxiliary component Secondary metabolites biosynthesis, transport, and catabolism 78484353 Common - Secretion protein HlyD Tcr_0007 90 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 78485918 Nonpathogen - hypothetical protein Tcr_1577 3 COG3462 COG3462, Predicted membrane protein Function unknown 78485178 Common - hypothetical protein Tcr_0833 21 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 78484448 Nonpathogen - hypothetical protein Tcr_0103 3 None None None 78485720 Common - Peptidylprolyl isomerase, FKBP-type Tcr_1376 128 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 78486222 Common - DEAD/DEAH box helicase-like Tcr_1883 231 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 78484565 Common - diaminobutyrate--2-oxoglutarate aminotransferase Tcr_0220 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 78485495 Common - response regulator receiver (CheY-like) and ANTAR domain protein Tcr_1151 118 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 78485510 Common - cell division topological specificity factor MinE Tcr_1166 97 COG0851 MinE, Septum formation topological specificity factor Cell division and chromosome partitioning 78485407 Common - hypothetical protein Tcr_1063 13 None None None 78484387 Common - 2OG-Fe(II) oxygenase Tcr_0041 31 COG3751 EGL-9, Predicted proline hydroxylase Posttranslational modification, protein turnover, chaperones 78485936 Common - thioredoxin Tcr_1595 230 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 78486405 Common - Nicotinamide mononucleotide transporter PnuC Tcr_2066 55 COG3201 PnuC, Nicotinamide mononucleotide transporter Coenzyme metabolism 78485138 Common - Peptidase S13, D-Ala-D-Ala carboxypeptidase C Tcr_0793 85 COG2027 DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) Cell envelope biogenesis, outer membrane 78486442 Common - hypothetical protein Tcr_2104 4 None None None 78485402 Nonpathogen - hypothetical protein Tcr_1058 4 None None None 78484367 Common - diguanylate cyclase Tcr_0021 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 78486279 Common - Peptidase M16-like Tcr_1940 174 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 78486365 Common - amino acid carrier protein Tcr_2026 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 78484751 Common - Protein of unknown function DUF484 Tcr_0406 40 COG3159 COG3159, Uncharacterized protein conserved in bacteria Function unknown 78484887 Common - histidine kinase Tcr_0542 220 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 78485979 Common - lipoate-protein ligase B Tcr_1638 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 78485449 Common - Protein of unknown function DUF785 Tcr_1105 34 COG4067 COG4067, Uncharacterized protein conserved in archaea Posttranslational modification, protein turnover, chaperones 78484573 Nonpathogen - hypothetical protein Tcr_0228 1 None None None 78486288 Common - tyrosyl-tRNA synthetase Tcr_1949 241 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 78484845 Common - diguanylate cyclase (GGDEF domain) Tcr_0500 175 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 78486152 Common - Protein of unknown function DUF205 Tcr_1811 170 COG0344 COG0344, Predicted membrane protein Function unknown 78485552 Common - hypothetical protein Tcr_1208 6 None None None 78486261 Common - hypothetical protein Tcr_1922 5 None None None 78484987 Common - type II secretion system protein Tcr_0642 147 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 78484559 Common - import inner membrane translocase, subunit Tim44 Tcr_0214 33 COG4395 COG4395, Uncharacterized protein conserved in bacteria Function unknown 78484839 Common - riboflavin biosynthesis protein RibF Tcr_0494 211 COG0196 RibF, FAD synthase Coenzyme metabolism 78486435 Common - Outer membrane efflux protein Tcr_2097 61 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 78486096 Common - Aminotransferase, class I and II Tcr_1755 240 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 78486328 Common - tryptophan synthase subunit beta Tcr_1989 225 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 78486210 Common - Beta-lactamase-like Tcr_1871 50 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 78485241 Common - Biopolymer transport protein ExbD/TolR Tcr_0896 129 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 78486517 Common - PAS/PAC sensor hybrid histidine kinase Tcr_2180 227 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 78485559 Common - 6-phosphogluconate dehydrogenase Tcr_1215 187 COG0362 Gnd, 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 78486241 Common - nucleotide-binding protein Tcr_1902 107 COG1666 COG1666, Uncharacterized protein conserved in bacteria Function unknown 78485395 Nonpathogen - hypothetical protein Tcr_1051 1 None None None 78485540 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Tcr_1196 229 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 78485732 Common - Polyprenyl synthetase Tcr_1388 242 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 78485113 Common - seryl-tRNA synthetase Tcr_0768 246 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 78484928 Nonpathogen - hypothetical protein Tcr_0583 1 None None None 78484370 Common - beta-lactamase-like Tcr_0024 124 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 78485901 Common - YgfB and YecA Tcr_1560 40 COG3079 COG3079, Uncharacterized protein conserved in bacteria Function unknown 78484598 Common - General secretion pathway protein G Tcr_0253 75 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 78486360 Common - Phospholipid/glycerol acyltransferase Tcr_2021 55 COG3176 COG3176, Putative hemolysin General function prediction only 78486420 Nonpathogen - hypothetical protein Tcr_2082 6 COG3624 PhnG, Uncharacterized enzyme of phosphonate metabolism Inorganic ion transport and metabolism 78484814 Common - hypothetical protein Tcr_0469 19 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 78485889 Common - ATP-dependent protease La Tcr_1548 199 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 78485780 Common - ATPase FliI/YscN Tcr_1439 247 COG1157 FliI, Flagellar biosynthesis/type III secretory pathway ATPase Cell motility and secretion / Intracellular trafficking and secretion 78485974 Common - Peptidoglycan glycosyltransferase Tcr_1633 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 78485305 Nonpathogen - hypothetical protein Tcr_0961 1 None None None 78484428 Common - hypothetical protein Tcr_0083 12 None None None 78485677 Common - queuine tRNA-ribosyltransferase Tcr_1333 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 78485882 Common - Aldo/keto reductase Tcr_1541 200 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 78485372 Nonpathogen - hypothetical protein Tcr_1028 1 None None None 78484589 Common - transketolase Tcr_0244 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 78485710 Common - N-acetyl-anhydromuranmyl-L-alanine amidase Tcr_1366 107 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 78485108 Common - thioredoxin reductase Tcr_0763 247 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 78484708 Common - pyridoxamine 5'-phosphate oxidase Tcr_0363 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 78485465 Common - Protein of unknown function DUF150 Tcr_1121 180 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 78486394 Common - hypothetical protein Tcr_2055 137 COG1561 COG1561, Uncharacterized stress-induced protein Function unknown 78484499 Common - delta-aminolevulinic acid dehydratase Tcr_0154 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 78485514 Common - sulfide-quinone reductase Tcr_1170 78 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 78485817 Common - response regulator receiver (CheY-like) modulated CheW protein Tcr_1476 126 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 78485824 Nonpathogen - hypothetical protein Tcr_1483 1 COG5373 COG5373, Predicted membrane protein Function unknown 78484487 Common - HAD-superfamily subfamily IIA hydrolase, hypothetical 2 Tcr_0142 105 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 78486236 Common - methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor Tcr_1897 170 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 78484456 Nonpathogen - hypothetical protein Tcr_0111 4 COG2143 COG2143, Thioredoxin-related protein Posttranslational modification, protein turnover, chaperones 78485227 Nonpathogen - hypothetical protein Tcr_0882 1 None None None 78485456 Common - AAA ATPase Tcr_1112 231 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 78485313 Common - two component transcriptional regulator, winged helix family Tcr_0969 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 78485243 Common - TolB-like Tcr_0898 154 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 78484874 Common - DNA-directed DNA polymerase Tcr_0529 248 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 78486159 Common - phosphoribosylaminoimidazole carboxylase, ATPase subunit Tcr_1818 193 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 78484618 Common - spermidine synthase Tcr_0273 118 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 78485795 Common - Protein of unknown function DUF115 Tcr_1454 19 COG2604 COG2604, Uncharacterized protein conserved in bacteria Function unknown 78485593 Common - threonine synthase Tcr_1249 133 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 78485454 Common - Heat shock protein DnaJ-like Tcr_1110 223 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 78485826 Common - neutral zinc metallopeptidase, zinc-binding site Tcr_1485 159 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 78484363 Common - coproporphyrinogen III oxidase Tcr_0017 113 COG0408 HemF, Coproporphyrinogen III oxidase Coenzyme metabolism 78485438 Common - adenylosuccinate synthetase Tcr_1094 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 78484566 Common - Peptidase M24 Tcr_0221 146 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 78485065 Common - TatD-related deoxyribonuclease Tcr_0720 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 78485543 Common - integration host factor, beta subunit Tcr_1199 207 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 78485185 Common - putative carboxysome structural peptide CsoS2 Tcr_0840 8 None None None 78484678 Common - Restriction modification system DNA specificity domain Tcr_0333 74 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 78485613 Common - Helicase c2 Tcr_1269 136 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 78485238 Common - Holliday junction DNA helicase RuvA Tcr_0893 211 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 78485656 Common - Peptidase U32 Tcr_1312 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 78485743 Common - riboflavin synthase subunit alpha Tcr_1399 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 78485821 Nonpathogen - hypothetical protein Tcr_1480 1 COG5581 COG5581, Predicted glycosyltransferase Cell envelope biogenesis, outer membrane 118139515 Common - hypothetical protein Tcr_1169 15 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 78486150 Common - ribosomal protein S21 Tcr_1809 100 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 78484742 Common - diguanylate cyclase (GGDEF domain) Tcr_0397 179 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 78485311 Common - Cytochrome B561 Tcr_0967 83 COG3038 CybB, Cytochrome B561 Energy production and conversion 78485352 Common - hypothetical protein Tcr_1008 35 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 78486454 Common - Copper-resistance protein CopA Tcr_2116 121 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 78485607 Common - PP-loop Tcr_1263 211 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 78484414 Common - Membrane protein involved in aromatic hydrocarbon degradation Tcr_0068 78 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 78485345 Common aceE pyruvate dehydrogenase subunit E1 Tcr_1001 151 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 78485877 Common - Glyoxalase I Tcr_1536 135 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 78485664 Nonpathogen - hypothetical protein Tcr_1320 1 None None None 78485024 Common - Phage portal protein, lambda Tcr_0679 38 COG5511 COG5511, Bacteriophage capsid protein General function prediction only 78485698 Common - hypothetical protein Tcr_1354 18 COG3266 DamX, Uncharacterized protein conserved in bacteria Function unknown 78485043 Common - Phage tail tape measure protein TP901, core region Tcr_0698 34 COG3941 COG3941, Mu-like prophage protein General function prediction only 78485623 Common - putative membrane-associated zinc metallopeptidase Tcr_1279 212 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 78485887 Common - N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase Tcr_1546 228 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 78484968 Common - hypothetical protein Tcr_0623 61 COG2976 COG2976, Uncharacterized protein conserved in bacteria Function unknown 78485339 Common - Inositol monophosphatase Tcr_0995 206 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 78485379 Common - electron transport complex, RnfABCDGE type, B subunit Tcr_1035 130 COG2878 COG2878, Predicted NADH:ubiquinone oxidoreductase, subunit RnfB Energy production and conversion 78486055 Common - UspA Tcr_1714 148 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 78486024 Nonpathogen - hypothetical protein Tcr_1683 3 None None None 78484682 Nonpathogen - hypothetical protein Tcr_0337 1 None None None 78486433 Common - Heavy metal efflux pump CzcA Tcr_2095 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 78484734 Common - peptide chain release factor 1 Tcr_0389 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 78485472 Common - ribosomal protein S15 Tcr_1128 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 78485943 Nonpathogen - hypothetical protein Tcr_1602 1 None None None 78486410 Common - ChaB Tcr_2071 21 COG4572 ChaB, Putative cation transport regulator General function prediction only 78484919 Common - methyl-accepting chemotaxis sensory transducer Tcr_0574 159 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 78484536 Common - sun protein Tcr_0191 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 78485303 Common - Protein of unknown function DUF343 Tcr_0959 85 COG2835 COG2835, Uncharacterized conserved protein Function unknown 78484690 Common - Chaperonin Cpn10 Tcr_0345 213 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 78485856 Common - hypothetical protein Tcr_1515 18 COG2990 VirK, Uncharacterized protein conserved in bacteria Function unknown 78484621 Common - hypothetical protein Tcr_0276 7 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 78486286 Common - putative transcriptional acitvator, Baf Tcr_1947 108 COG1521 COG1521, Putative transcriptional regulator, homolog of Bvg accessory factor Transcription 78485870 Common - Rhodanese-like Tcr_1529 36 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 78485381 Common - methionyl-tRNA synthetase Tcr_1037 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 78486061 Nonpathogen - hypothetical protein Tcr_1720 1 None None None 78484773 Common - Ribulose-bisphosphate carboxylase Tcr_0428 29 COG4451 RbcS, Ribulose bisphosphate carboxylase small subunit Energy production and conversion 78484515 Common - hypothetical protein Tcr_0170 29 None None None 78485230 Common - ROK Tcr_0885 141 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 78485772 Common - Type III secretion system outer membrane O protein Tcr_1431 123 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 78484668 Common - hypothetical protein Tcr_0323 7 None None None 78486208 Common - hypothetical protein Tcr_1869 66 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 78484812 Nonpathogen - hypothetical protein Tcr_0467 1 None None None 78485153 Common - amidophosphoribosyltransferase Tcr_0808 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 78485397 Common - Protein of unknown function DUF519 Tcr_1053 85 COG2961 ComJ, Protein involved in catabolism of external DNA General function prediction only 78486457 Common - putative transposase Tcr_2119 43 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 78484386 Common - cyanate lyase Tcr_0040 41 COG1513 CynS, Cyanate lyase Inorganic ion transport and metabolism 78486243 Common - putative signal transduction protein Tcr_1904 52 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 78485285 Nonpathogen - Protein of unknown function DUF1232 Tcr_0941 1 COG3339 COG3339, Uncharacterized conserved protein Function unknown 78484439 Common - Major facilitator superfamily MFS_1 Tcr_0094 124 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 78485200 Common - Histone deacetylase superfamily Tcr_0855 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 78486407 Common - multi-sensor hybrid histidine kinase Tcr_2068 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 78486330 Common - outer membrane lipoprotein, lipocalin Tcr_1991 66 COG3040 Blc, Bacterial lipocalin Cell envelope biogenesis, outer membrane 78484416 Common - AMP-dependent synthetase and ligase Tcr_0070 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 78485949 Common - Peptidase S8 and S53, subtilisin, kexin, sedolisin Tcr_1608 53 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 78485270 Common - Lytic transglycosylase, catalytic Tcr_0925 122 COG4623 COG4623, Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein Cell envelope biogenesis, outer membrane 78485786 Common - PAS/PAC sensor signal transduction histidine kinase Tcr_1445 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 78484882 Common - Binding-protein-dependent transport systems inner membrane component Tcr_0537 225 COG4590 COG4590, ABC-type uncharacterized transport system, permease component General function prediction only 78484638 Common - elongation factor Tu Tcr_0293 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 78486527 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) Tcr_2190 199 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 78486066 Common - type II secretion system protein E Tcr_1725 226 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 78484606 Common - dethiobiotin synthase Tcr_0261 151 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 78486180 Common metX homoserine O-acetyltransferase Tcr_1839 133 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 78484728 Nonpathogen - Heavy metal transport/detoxification protein Tcr_0383 6 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 78484351 Common - periplasmic sensor signal transduction histidine kinase Tcr_0005 201 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 78485557 Common - 6-phosphogluconolactonase Tcr_1213 125 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 78486495 Common - hypothetical protein Tcr_2158 24 COG1416 COG1416, Uncharacterized conserved protein Function unknown 78486448 Common - Heavy metal translocating P-type ATPase Tcr_2110 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 118139524 Nonpathogen - Phage AlpA family protein Tcr_2205 4 COG3311 AlpA, Predicted transcriptional regulator Transcription 78484601 Common - General secretion pathway protein J Tcr_0256 33 COG4795 PulJ, Type II secretory pathway, component PulJ Intracellular trafficking and secretion 78485134 Common - Protein of unknown function DUF469 Tcr_0789 21 COG3171 COG3171, Uncharacterized protein conserved in bacteria Function unknown 78485689 Common - Glutamate synthase, alpha subunit-like Tcr_1345 59 COG0070 GltB, Glutamate synthase domain 3 Amino acid transport and metabolism 78484937 Common - hypothetical protein Tcr_0592 171 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 78484805 Common - putative transcriptional regulator, ModE family Tcr_0460 96 COG2005 ModE, N-terminal domain of molybdenum-binding protein General function prediction only 78485922 Common - UDP-N-acetylmuramate Tcr_1581 211 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 78485685 Common - GCN5-related N-acetyltransferase Tcr_1341 53 COG0456 RimI, Acetyltransferases General function prediction only 78485811 Common - hypothetical protein Tcr_1470 119 COG4787 FlgF, Flagellar basal body rod protein Cell motility and secretion 78484596 Common - type II secretion system protein E Tcr_0251 221 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 78485419 Common - prolyl-tRNA synthetase Tcr_1075 247 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 78485479 Common - ABC-2 Tcr_1135 117 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 78485026 Common - hypothetical protein Tcr_0681 7 None None None 78485362 Common - Cobyrinic acid a,c-diamide synthase Tcr_1018 201 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 78485739 Common - thiamine-monophosphate kinase Tcr_1395 194 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 78485089 Common - flagellar biosynthesis protein FlhA Tcr_0744 127 COG1298 FlhA, Flagellar biosynthesis pathway, component FlhA Cell motility and secretion / Intracellular trafficking and secretion 78486310 Common - Histidine triad (HIT) protein Tcr_1971 226 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 78485875 Common - Protein of unknown function DUF1255 Tcr_1534 53 COG3123 COG3123, Uncharacterized protein conserved in bacteria Function unknown 78485173 Common - proton-translocating NADH-quinone oxidoreductase, chain L Tcr_0828 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 78485757 Common - TRAP dicarboxylate transporter- DctM subunit Tcr_1414 136 COG4664 FcbT3, TRAP-type mannitol/chloroaromatic compound transport system, large permease component Secondary metabolites biosynthesis, transport, and catabolism 78486461 Common - hypothetical protein Tcr_2123 22 COG3655 COG3655, Predicted transcriptional regulator Transcription 78485599 Common - DedA Tcr_1255 62 COG1238 COG1238, Predicted membrane protein Function unknown 78486018 Common - Phosphomannomutase Tcr_1677 243 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 78484803 Nonpathogen - hypothetical protein Tcr_0458 2 None None None 78485484 Common - Protein of unknown function DUF482 Tcr_1140 81 COG3146 COG3146, Uncharacterized protein conserved in bacteria Function unknown 78484624 Common - Pseudouridine synthase Tcr_0279 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 78485215 Common - Heat shock protein Hsp70 Tcr_0870 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 78485845 Common - SH3-like region Tcr_1504 38 COG3103 COG3103, SH3 domain protein Signal transduction mechanisms 78485187 Common - Ethanolamine utilization protein EutN/carboxysome structural protein Ccml Tcr_0842 10 COG4576 CcmL, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 78486385 Common - Thiol-disulfide isomerase and thioredoxins-like Tcr_2046 161 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 78484785 Common - transcriptional regulator, Fis family Tcr_0440 97 COG2901 Fis, Factor for inversion stimulation Fis, transcriptional activator Transcription / DNA replication, recombination, and repair 78485697 Common - hypothetical protein Tcr_1353 8 None None None 78485993 Common - Nucleotidyl transferase Tcr_1652 200 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 78486185 Nonpathogen - hypothetical protein Tcr_1844 1 None None None 78485411 Common - hypothetical protein Tcr_1067 59 COG3174 COG3174, Predicted membrane protein Function unknown 78486082 Common - translation elongation factor P Tcr_1741 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 78484721 Common - hypothetical protein Tcr_0376 21 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 78484717 Common - hypothetical protein Tcr_0372 9 None None None 78484490 Common thiG thiazole synthase Tcr_0145 166 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 78485493 Common - hypothetical protein Tcr_1149 5 None None None 78486143 Common - hypothetical protein Tcr_1802 5 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 78484869 Common - Outer membrane efflux protein Tcr_0524 33 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 78485341 Common - Cytochrome c assembly protein Tcr_0997 98 COG4137 COG4137, ABC-type uncharacterized transport system, permease component General function prediction only 78484993 Common - 16S rRNA processing protein RimM Tcr_0648 161 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 78485539 Common - Prephenate dehydrogenase Tcr_1195 171 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 78485421 Common - Protein of unknown function DUF1275 Tcr_1077 13 COG3619 COG3619, Predicted membrane protein Function unknown 78485105 Nonpathogen - hypothetical protein Tcr_0760 1 None None None 78485307 Common - TonB-dependent receptor Tcr_0963 125 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 78484975 Common - GTPase EngC Tcr_0630 163 COG1162 COG1162, Predicted GTPases General function prediction only 78485984 Common - hypothetical protein Tcr_1643 36 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 78484911 Common - UDP-N-acetylmuramoylalanine--D-glutamate ligase Tcr_0566 211 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 78485693 Common - Aminomethyltransferase Tcr_1349 189 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 78485920 Nonpathogen - hypothetical protein Tcr_1579 1 COG3462 COG3462, Predicted membrane protein Function unknown 78484756 Common - Protein of unknown function DUF1334 Tcr_0411 15 COG2862 COG2862, Predicted membrane protein Function unknown 78485712 Common - Potassium efflux system protein Tcr_1368 214 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 78485662 Nonpathogen - hypothetical protein Tcr_1318 1 None None None 78484523 Common - Pyridoxamine 5'-phosphate oxidase-related, FMN-binding Tcr_0178 20 COG0748 HugZ, Putative heme iron utilization protein Inorganic ion transport and metabolism 78484479 Common - cyclic-AMP phosphodiesterase Tcr_0134 35 COG5212 PDE1, Low-affinity cAMP phosphodiesterase Signal transduction mechanisms 78484822 Common - apolipoprotein N-acyltransferase Tcr_0477 165 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 78486165 Common - Glutamate--cysteine ligase GshA Tcr_1824 27 None None None 78485289 Common - Short-chain dehydrogenase/reductase SDR Tcr_0945 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 78486268 Common - HPP Tcr_1929 68 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 78486322 Common - hypothetical protein Tcr_1983 5 None None None 78486184 Nonpathogen - hypothetical protein Tcr_1843 1 None None None 78484385 Common - OsmC-like protein Tcr_0039 15 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 78484862 Nonpathogen - hypothetical protein Tcr_0517 1 None None None 78486128 Common - Binding-protein-dependent transport systems inner membrane component Tcr_1787 159 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 78484701 Common - Histidinol-phosphate phosphatase Tcr_0356 128 COG0241 HisB, Histidinol phosphatase and related phosphatases Amino acid transport and metabolism 78486263 Common - multi-sensor hybrid histidine kinase Tcr_1924 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 78485522 Common clpX ATP-dependent protease ATP-binding subunit Tcr_1178 226 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 78484553 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Tcr_0208 169 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 78484533 Common - two component, sigma54 specific, transcriptional regulator, Fis family Tcr_0188 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 78486396 Common - fructosamine kinase Tcr_2057 70 COG3001 COG3001, Uncharacterized protein conserved in bacteria Function unknown 78485130 Common - diguanylate cyclase (GGDEF domain) Tcr_0785 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 78485328 Common - ABC transporter related Tcr_0984 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 78484489 Common - Thiamine-phosphate diphosphorylase Tcr_0144 196 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 78485160 Common - triosephosphate isomerase Tcr_0815 216 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 78485044 Common - hypothetical protein Tcr_0699 8 COG3499 COG3499, Phage protein U General function prediction only 78484813 Nonpathogen - methylation site Tcr_0468 1 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 78486231 Common - Ppx/GppA phosphatase Tcr_1892 181 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 78484480 Common - response regulator receiver domain protein (CheY-like) Tcr_0135 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 78486124 Common - hypothetical protein Tcr_1783 19 None None None 78484767 Common - von Willebrand factor, type A Tcr_0422 49 COG4548 NorD, Nitric oxide reductase activation protein Inorganic ion transport and metabolism 78485072 Common - Glycine cleavage T protein (aminomethyl transferase) Tcr_0727 133 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 78486194 Common - Transposase IS3/IS911 Tcr_1853 66 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 78484676 Common - hypothetical protein Tcr_0331 13 None None None 78485423 Common - deoxyguanosinetriphosphate triphosphohydrolase-like protein Tcr_1079 159 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 78485669 Common - hypothetical protein Tcr_1325 84 COG1981 COG1981, Predicted membrane protein Function unknown 118139510 Common - aspartate kinase Tcr_0521 169 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 78484826 Common - DNA polymerase III, delta subunit Tcr_0481 85 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 78484508 Nonpathogen - hypothetical protein Tcr_0163 3 None None None 78485726 Common - two component transcriptional regulator, LuxR family Tcr_1382 216 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 78485224 Common - carbamoyl-phosphate synthase, large subunit Tcr_0879 236 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 78485679 Common - hypothetical protein Tcr_1335 8 None None None 78485144 Common - Protein of unknown function DUF583 Tcr_0799 60 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 78485507 Common - Molybdopterin-guanine dinucleotide biosynthesis protein A-like Tcr_1163 61 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 78486340 Common - Secretion protein HlyD Tcr_2001 162 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 78486131 Common - hypothetical protein Tcr_1790 45 COG3665 COG3665, Uncharacterized conserved protein Function unknown 78485051 Common - maf protein Tcr_0706 189 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 78485447 Common - Excinuclease ABC, C subunit-like Tcr_1103 80 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 78486278 Common - LrgA Tcr_1939 74 COG1380 COG1380, Putative effector of murein hydrolase LrgA General function prediction only 78484369 Common - Lysine exporter protein (LYSE/YGGA) Tcr_0023 107 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 78485240 Common - MotA/TolQ/ExbB proton channel Tcr_0895 152 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 78485371 Nonpathogen - hypothetical protein Tcr_1027 2 None None None 78484986 Common - type II secretion system protein E Tcr_0641 216 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 78485512 Common - transcription-repair coupling factor Tcr_1168 237 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 78486094 Common - hypothetical protein Tcr_1753 13 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 78484376 Common - Sodium/hydrogen exchanger Tcr_0030 29 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 78485519 Common - hypothetical protein Tcr_1175 14 None None None 78485453 Common - PhnA protein Tcr_1109 101 COG2824 PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism Inorganic ion transport and metabolism 78484608 Nonpathogen - Phosphate-starvation-inducible E Tcr_0263 2 COG3223 COG3223, Predicted membrane protein Function unknown 78484781 Common - hypothetical protein Tcr_0436 21 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 78484557 Common - UvrD/REP helicase Tcr_0212 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 78486275 Common - hypothetical protein Tcr_1936 8 None None None 78485482 Nonpathogen - hypothetical protein Tcr_1138 4 None None None 78486229 Common - Protein of unknown function DUF37 Tcr_1890 185 COG0759 COG0759, Uncharacterized conserved protein Function unknown 78484578 Nonpathogen - hypothetical protein Tcr_0233 5 None None None 78486011 Common - putative signal transduction protein Tcr_1670 59 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 78484615 Common - hypothetical protein Tcr_0270 11 None None None 78485917 Common - Bilirubin oxidase Tcr_1576 125 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 78485976 Common - Serine-type D-Ala-D-Ala carboxypeptidase Tcr_1635 155 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 78484788 Common - acetyl-CoA carboxylase, biotin carboxylase Tcr_0443 236 COG0439 AccC, Biotin carboxylase Lipid metabolism 78484560 Nonpathogen - hypothetical protein Tcr_0215 1 None None None 78485897 Common - Ion transport protein Tcr_1556 73 None None None 78485269 Common - Lytic transglycosylase, catalytic Tcr_0924 166 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 78485848 Common - maf protein Tcr_1507 198 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 78485333 Common - histidinol dehydrogenase Tcr_0989 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 78484921 Common - ABC transporter related Tcr_0576 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 78485229 Common - hypothetical protein Tcr_0884 20 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 78484459 Common - hypothetical protein Tcr_0114 5 COG3879 COG3879, Uncharacterized protein conserved in bacteria Function unknown 78485730 Common - CBS domain containing membrane protein Tcr_1386 156 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 78485888 Common - Molybdopterin binding domain Tcr_1547 186 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 78485558 Common - glucose-6-phosphate 1-dehydrogenase Tcr_1214 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 78485644 Common - ErfK/YbiS/YcfS/YnhG Tcr_1300 40 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 78485079 Common - Ribonuclease III Tcr_0734 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 78485085 Common fliP flagellar biosynthesis protein FliP Tcr_0740 128 COG1338 FliP, Flagellar biosynthesis pathway, component FliP Cell motility and secretion / Intracellular trafficking and secretion 78485018 Nonpathogen - hypothetical protein Tcr_0673 1 None None None 78485904 Common - threonine dehydratase, biosynthetic Tcr_1563 229 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 78485841 Common - ammonium transporter Tcr_1500 201 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 78484563 Common - Exonuclease Tcr_0218 4 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 78485012 Common - putative bacteriophage protein (Gp55-like) Tcr_0667 5 None None None 78484462 Common - Putative oxygen-independent coproporphyrinogen III oxidase Tcr_0117 205 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 78485568 Common - transcriptional regulator, AraC family Tcr_1224 123 COG3449 COG3449, DNA gyrase inhibitor DNA replication, recombination, and repair 78485862 Common - Phosphoenolpyruvate carboxylase Tcr_1521 116 COG2352 Ppc, Phosphoenolpyruvate carboxylase Energy production and conversion 78486218 Common - Thioredoxin-related Tcr_1879 124 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 78485292 Common - ATP-dependent RNA helicase DbpA Tcr_0948 236 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 78484460 Common - HemY-like Tcr_0115 61 COG3071 HemY, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 78485960 Common - RDD Tcr_1619 14 COG1714 COG1714, Predicted membrane protein/domain Function unknown 78485404 Nonpathogen - hypothetical protein Tcr_1060 1 None None None 78484706 Common - methyl-accepting chemotaxis sensory transducer Tcr_0361 156 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 78486469 Common purT phosphoribosylglycinamide formyltransferase 2 Tcr_2132 220 COG0027 PurT, Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) Nucleotide transport and metabolism 78485262 Common - Sodium:dicarboxylate symporter Tcr_0917 161 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 78486336 Common - permease Tcr_1997 102 COG0701 COG0701, Predicted permeases General function prediction only 78484423 Common - methyl-accepting chemotaxis sensory transducer Tcr_0077 165 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 78485776 Common - chemotaxis protein Tcr_1435 99 COG1291 MotA, Flagellar motor component Cell motility and secretion 78484358 Common - DNA gyrase, B subunit Tcr_0012 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 78484403 Common - Acriflavin resistance protein Tcr_0057 178 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 78484907 Common - Peptidoglycan glycosyltransferase Tcr_0562 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 78484666 Common - TatD-related deoxyribonuclease Tcr_0321 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 78484452 Nonpathogen - hypothetical protein Tcr_0107 1 None None None 78486422 Common - Phosphonate metabolism Tcr_2084 45 COG3626 PhnI, Uncharacterized enzyme of phosphonate metabolism Inorganic ion transport and metabolism 78485315 Common - magnesium transporter Tcr_0971 170 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 78486332 Common - hypothetical protein Tcr_1993 49 COG0348 NapH, Polyferredoxin Energy production and conversion 78486293 Common - Glutaredoxin Tcr_1954 109 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 78485655 Common - 4Fe-4S ferredoxin, iron-sulfur binding Tcr_1311 107 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 78485489 Common - excinuclease ABC, C subunit Tcr_1145 224 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 78484941 Common - Glutaredoxin-related protein Tcr_0596 126 COG0278 COG0278, Glutaredoxin-related protein Posttranslational modification, protein turnover, chaperones 78485393 Common - thioredoxin Tcr_1049 158 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 78486004 Common - phenylalanyl-tRNA synthetase, alpha subunit Tcr_1663 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 78484890 Common - Ferredoxin Tcr_0545 69 COG0633 Fdx, Ferredoxin Energy production and conversion 78485193 Nonpathogen - hypothetical protein Tcr_0848 4 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 78485614 Common - ribosomal protein L36 Tcr_1270 68 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 78486479 Common - Three-deoxy-D-manno-octulosonic-acid transferase-like Tcr_2142 128 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 78485067 Common - Heavy metal translocating P-type ATPase Tcr_0722 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 78485437 Common - ATP phosphoribosyltransferase regulatory subunit Tcr_1093 201 COG3705 HisZ, ATP phosphoribosyltransferase involved in histidine biosynthesis Amino acid transport and metabolism 78486198 Common - Transposase IS3/IS911 Tcr_1858 61 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 78485935 Common - DNA mismatch repair protein MutS Tcr_1594 200 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 78486296 Common gltB glutamate synthase subunit alpha Tcr_1957 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 78485753 Common smpB SsrA-binding protein Tcr_1409 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 78485896 Common - transcriptional regulator, LysR family Tcr_1555 193 COG0583 LysR, Transcriptional regulator Transcription 118139517 Nonpathogen - hypothetical protein Tcr_1425 1 None None None 78486109 Common - Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)-like Tcr_1768 89 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 78486484 Common - ABC-type Mn2+/Zn2+ transport systems permease components Tcr_2147 155 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 78485222 Common - hypothetical protein Tcr_0877 12 None None None 78484832 Nonpathogen - Transglycosylase-associated protein Tcr_0487 1 None None None 78484347 Common - chromosomal replication initiator protein DnaA Tcr_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 78484645 Common - ribosomal protein L22 Tcr_0300 218 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 78484816 Common - ATP-binding region, ATPase-like Tcr_0471 10 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 78486176 Common - hypothetical protein Tcr_1835 6 None None None 78486306 Common - imidazole glycerol phosphate synthase, glutamine amidotransferase subunit Tcr_1967 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 78485036 Common - hypothetical protein Tcr_0691 16 None None None 78484777 Common - hypothetical protein Tcr_0432 7 None None None 78484585 Common - metal dependent phosphohydrolase Tcr_0240 212 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 78486248 Common - choline/carnitine/betaine transport Tcr_1909 96 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 78485827 Common - OmpA/MotB Tcr_1486 145 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 78486227 Common - diguanylate phosphodiesterase (EAL domain) Tcr_1888 85 COG3434 COG3434, Predicted signal transduction protein containing EAL and modified HD-GYP domains Signal transduction mechanisms 78485219 Common - hypothetical protein Tcr_0874 10 COG1416 COG1416, Uncharacterized conserved protein Function unknown 78485967 Common - heat shock protein HtpX Tcr_1626 191 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 78486042 Nonpathogen - hypothetical protein Tcr_1701 4 None None None 78485267 Common - glutaminyl-tRNA synthetase Tcr_0922 245 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 78484867 Common - TPR repeat domain protein Tcr_0522 29 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 78485830 Common - RNA methyltransferase TrmH, group 3 Tcr_1489 217 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 78485498 Common - Binding-protein-dependent transport systems inner membrane component Tcr_1154 135 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 78484541 Common - DNA topoisomerase Tcr_0196 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 78484779 Common - Protein of unknown function DUF214 Tcr_0434 108 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 78485807 Common - flagellar biosynthesis Tcr_1466 46 COG3951 COG3951, Rod binding protein Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 78484914 Common - Short-chain dehydrogenase/reductase SDR Tcr_0569 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 78486529 Common - hypothetical protein Tcr_2192 133 COG1739 COG1739, Uncharacterized conserved protein Function unknown 78484419 Common - von Willebrand factor, type A Tcr_0073 86 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 78486021 Common - GDP-mannose 4,6-dehydratase Tcr_1680 227 COG1089 Gmd, GDP-D-mannose dehydratase Cell envelope biogenesis, outer membrane 78484398 Common - hypothetical protein Tcr_0052 7 None None None 78484726 Common - hypothetical protein Tcr_0381 53 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 78484801 Common - Cobalamin synthesis protein/P47K Tcr_0456 127 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 78486463 Common - Deoxyribodipyrimidine photolyase Tcr_2125 138 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 78484457 Common - porphobilinogen deaminase Tcr_0112 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 78484591 Common - Phosphoglycerate kinase Tcr_0246 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 78485279 Common - Phospholipase D/Transphosphatidylase Tcr_0934 149 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 78486250 Common - response regulator receiver (CheY-like) modulated metal dependent phosphohydrolase Tcr_1911 124 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 78485528 Common - Binding-protein-dependent transport systems inner membrane component Tcr_1184 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 78484626 Common - elongation factor Tu Tcr_0281 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 78486383 Nonpathogen - hypothetical protein Tcr_2044 7 COG2215 COG2215, ABC-type uncharacterized transport system, permease component General function prediction only 78484770 Common - transcriptional regulator, LysR family Tcr_0425 191 COG0583 LysR, Transcriptional regulator Transcription 78484635 Common rpsL 30S ribosomal protein S12 Tcr_0290 239 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 78485100 Common - CheW protein Tcr_0755 125 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 78484991 Common - Protein of unknown function DUF195 Tcr_0646 117 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 78485982 Common - Transposase IS3/IS911 Tcr_1641 61 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 78484857 Common - Glycogen/starch synthase, ADP-glucose type Tcr_0512 159 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 78485368 Common - dihydropteridine reductase Tcr_1024 72 COG0778 NfnB, Nitroreductase Energy production and conversion 78485649 Common - Adenylate cyclase Tcr_1305 47 COG2954 COG2954, Uncharacterized protein conserved in bacteria Function unknown 78484354 Common - Heavy metal efflux pump CzcA Tcr_0008 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 78485001 Common - Phage integrase Tcr_0656 38 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 78486374 Common - (NiFe) hydrogenase maturation protein HypF Tcr_2035 115 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 78485028 Nonpathogen - hypothetical protein Tcr_0683 1 None None None 78486016 Common - Undecaprenyl-phosphate galactosephosphotransferase Tcr_1675 183 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 78484655 Common - Ribosomal protein L6 Tcr_0310 246 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 78484546 Common - Protein of unknown function DUF526 Tcr_0201 52 COG2960 COG2960, Uncharacterized protein conserved in bacteria Function unknown 78486509 Nonpathogen - hypothetical protein Tcr_2172 2 None None None 78485413 Common - protein-L-isoaspartate O-methyltransferase Tcr_1069 169 COG2312 COG2312, Erythromycin esterase homolog General function prediction only 78486413 Nonpathogen - hypothetical protein Tcr_2074 1 None None None 78486302 Common - cytochrome c oxidase, cbb3-type, subunit III Tcr_1963 69 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 78486351 Common - conserved hypothetical cytosolic protein Tcr_2012 15 None None None 78484876 Common - recombination protein RecR Tcr_0531 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 78485538 Common - histidinol-phosphate aminotransferase Tcr_1194 240 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 78485239 Common ruvB Holliday junction DNA helicase B Tcr_0894 226 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 78485545 Common - orotidine 5'-phosphate decarboxylase Tcr_1201 167 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 78484808 Common - ribonucleotide-diphosphate reductase subunit alpha Tcr_0463 210 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 78486492 Nonpathogen - hypothetical protein Tcr_2155 2 COG1416 COG1416, Uncharacterized conserved protein Function unknown 78484450 Common - VCBS Tcr_0105 177 COG4254 COG4254, Uncharacterized protein conserved in bacteria Function unknown 78484935 Common argJ bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein Tcr_0590 167 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 78485788 Nonpathogen - hypothetical protein Tcr_1447 1 None None None 78486053 Nonpathogen - hypothetical protein Tcr_1712 1 None None None 78486081 Common - Lysine--tRNA ligase Tcr_1740 202 COG2269 COG2269, Truncated, possibly inactive, lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 78484441 Common - Protein of unknown function DUF58 Tcr_0096 68 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 78485095 Common - CheA signal transduction histidine kinase Tcr_0750 150 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 78485639 Common - MscS Mechanosensitive ion channel Tcr_1295 226 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 78484430 Nonpathogen - hypothetical protein Tcr_0085 3 None None None 78485202 Nonpathogen - BFD-like (2Fe-2S)-binding region Tcr_0857 1 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 78485277 Common - Beta-lactamase-like Tcr_0932 209 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 78486477 Common - Iron-containing alcohol dehydrogenase Tcr_2140 146 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 78484473 Common uvrD DNA-dependent helicase II Tcr_0128 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 78485872 Common - Secretion protein HlyD Tcr_1531 156 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 78484432 Nonpathogen - hypothetical protein Tcr_0087 2 None None None 78484493 Common - thiamine biosynthesis protein ThiC Tcr_0148 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 78485687 Common - Methenyltetrahydrofolate cyclohydrolase Tcr_1343 223 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 78485879 Common - chorismate synthase Tcr_1538 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 78485755 Common - Protein of unknown function DUF81 Tcr_1412 156 COG0730 COG0730, Predicted permeases General function prediction only 78485578 Common - putative prophage repressor Tcr_1234 173 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 78484977 Common - Ste24 endopeptidase Tcr_0632 126 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 78485451 Common - Alpha-L-glutamate ligase-related protein Tcr_1107 18 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 78485745 Common - hypothetical protein Tcr_1401 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 78486026 Nonpathogen - hypothetical protein Tcr_1685 1 None None None 78486157 Common - undecaprenol kinase, putative Tcr_1816 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 78484396 Common - DSBA oxidoreductase Tcr_0050 66 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 78486088 Common - permease YjgP/YjgQ Tcr_1747 115 COG0795 COG0795, Predicted permeases General function prediction only 78486400 Common - S6 modification enzyme RimK Tcr_2061 160 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 78484588 Common - Acriflavin resistance protein Tcr_0243 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 78486050 Common - 2-oxoglutarate synthase Tcr_1709 111 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 78486035 Common - Putative lipoprotein-like Tcr_1694 29 COG3107 LppC, Putative lipoprotein General function prediction only 78486428 Common phnP carbon-phosphorus lyase complex accessory protein Tcr_2090 72 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 78485154 Common - O-succinylhomoserine sulfhydrylase Tcr_0809 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 78486289 Common - dihydroorotate dehydrogenase family protein Tcr_1950 222 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 78485909 Common - ribose-5-phosphate isomerase A Tcr_1568 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 78485189 Common - microcompartments protein Tcr_0844 46 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 78484966 Common - hypothetical protein Tcr_0621 11 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 78485583 Common - DNA ligase, NAD-dependent Tcr_1239 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 78486041 Common - Beta-lactamase-like Tcr_1700 63 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 78485770 Common - Heavy metal efflux pump CzcA Tcr_1428 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 78484538 Common - Peptide deformylase Tcr_0193 215 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 78484687 Common rpmA 50S ribosomal protein L27 Tcr_0342 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 78485112 Common - crcB protein Tcr_0767 119 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 78484685 Common - Trans-hexaprenyltranstransferase Tcr_0340 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 78486369 Nonpathogen - hypothetical protein Tcr_2030 2 COG2142 SdhD, Succinate dehydrogenase, hydrophobic anchor subunit Energy production and conversion 78484374 Common - diguanylate phosphodiesterase (EAL domain) Tcr_0028 162 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 78486345 Common - Tripartite ATP-independent periplasmic transporter, DctQ component Tcr_2006 66 COG4665 FcbT2, TRAP-type mannitol/chloroaromatic compound transport system, small permease component Secondary metabolites biosynthesis, transport, and catabolism 78485466 Common - NusA antitermination factor Tcr_1122 217 COG0195 NusA, Transcription elongation factor Transcription 78484736 Common - TPR repeat domain protein Tcr_0391 131 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 78486048 Common - Protein of unknown function DUF45 Tcr_1707 157 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 78485765 Common - hypothetical protein Tcr_1422 10 None None None 78486431 Nonpathogen - hypothetical protein Tcr_2093 2 None None None 78484740 Common - translation-associated GTPase Tcr_0395 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 78485354 Common - Flavoprotein WrbA Tcr_1010 118 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 78485312 Common - histidine kinase Tcr_0968 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 78484850 Common - bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase Tcr_0505 190 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 78485588 Common - hypothetical protein Tcr_1244 56 COG2187 COG2187, Uncharacterized protein conserved in bacteria Function unknown 78484568 Common - hypothetical protein Tcr_0223 8 None None None 78485919 Nonpathogen - hypothetical protein Tcr_1578 7 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 78486178 Common - pyrroline-5-carboxylate reductase Tcr_1837 215 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 78484794 Common - Membrane protein involved in aromatic hydrocarbon degradation Tcr_0449 46 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 78486531 Common - RNA methyltransferase, TrmA family Tcr_2194 199 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 78485476 Common - Transcription factor jumonji, jmjC Tcr_1132 59 COG2850 COG2850, Uncharacterized conserved protein Function unknown 78484531 Common - K+ transporter Trk Tcr_0186 141 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 78485947 Common - ABC transporter related Tcr_1606 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 78485232 Common - Patatin Tcr_0887 142 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 78485835 Common - putative signal transduction protein Tcr_1494 33 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 78485217 Common - dihydrodipicolinate reductase Tcr_0872 217 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 78485911 Common - glutamate-1-semialdehyde-2,1-aminomutase Tcr_1570 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 78484999 Nonpathogen - hypothetical protein Tcr_0654 1 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 78484412 Common - periplasmic sensor hybrid histidine kinase Tcr_0066 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 78485394 Nonpathogen - hypothetical protein Tcr_1050 1 None None None 78484712 Nonpathogen - phage exclusion protein Lit Tcr_0367 1 None None None 78485162 Common - NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Tcr_0817 162 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 78486489 Common - Antibiotic biosynthesis monooxygenase Tcr_2152 7 COG1359 COG1359, Uncharacterized conserved protein Function unknown 78486155 Nonpathogen - hypothetical protein Tcr_1814 1 COG1536 FliG, Flagellar motor switch protein Cell motility and secretion 78485651 Common - UbiA prenyltransferase Tcr_1307 39 COG1575 MenA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase Coenzyme metabolism 78486216 Common - transcriptional regulator, AsnC family Tcr_1877 159 COG1522 Lrp, Transcriptional regulators Transcription 78485256 Nonpathogen - hypothetical protein Tcr_0911 1 None None None 78484953 Common - Glucose-6-phosphate isomerase Tcr_0608 192 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 78485343 Common - HAD-superfamily subfamily IB, PSPase-like Tcr_0999 71 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 78485724 Common - cob(I)alamin adenosyltransferase Tcr_1380 142 COG2109 BtuR, ATP:corrinoid adenosyltransferase Coenzyme metabolism 78484749 Common hslU ATP-dependent protease ATP-binding subunit Tcr_0404 212 COG1220 HslU, ATP-dependent protease HslVU (ClpYQ), ATPase subunit Posttranslational modification, protein turnover, chaperones 78486189 Nonpathogen - hypothetical protein Tcr_1848 1 None None None 78485529 Common - ABC transporter related Tcr_1185 249 COG4172 COG4172, ABC-type uncharacterized transport system, duplicated ATPase component General function prediction only 78485556 Common - (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA Tcr_1212 205 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 78485391 Nonpathogen - hypothetical protein Tcr_1047 1 None None None 78486126 Common - Histone deacetylase superfamily Tcr_1785 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 78486441 Common - Iron permease FTR1 Tcr_2103 61 COG0672 FTR1, High-affinity Fe2+/Pb2+ permease Inorganic ion transport and metabolism 78485561 Common - Peptidase M61 Tcr_1217 56 COG3975 COG3975, Predicted protease with the C-terminal PDZ domain General function prediction only 78485715 Common - competence lipoprotein ComL Tcr_1371 125 COG4105 ComL, DNA uptake lipoprotein General function prediction only 78485445 Common - isocitrate dehydrogenase, NADP-dependent Tcr_1101 65 COG2838 Icd, Monomeric isocitrate dehydrogenase Energy production and conversion 78484755 Common - ATP-dependent protease peptidase subunit Tcr_0410 149 COG5405 HslV, ATP-dependent protease HslVU (ClpYQ), peptidase subunit Posttranslational modification, protein turnover, chaperones 78486498 Common - 4-hydroxybenzoate polyprenyl transferase Tcr_2161 160 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 78485793 Common - Flagellin-like Tcr_1452 123 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 78484555 Common - OmpA/MotB Tcr_0210 152 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 78485915 Common - Copper resistance B precursor Tcr_1574 42 COG3667 PcoB, Uncharacterized protein involved in copper resistance Inorganic ion transport and metabolism 118139512 Nonpathogen - hypothetical protein Tcr_0664 2 None None None 78485941 Common - Metallophosphoesterase Tcr_1600 79 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 78484797 Common - hypothetical protein Tcr_0452 78 COG2945 COG2945, Predicted hydrolase of the alpha/beta superfamily General function prediction only 78485550 Nonpathogen - hypothetical protein Tcr_1206 1 None None None 78485167 Common - NADH-quinone oxidoreductase, F subunit Tcr_0822 165 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 78485226 Common - hypothetical protein Tcr_0881 2 None None None 78485853 Common - hypothetical protein Tcr_1512 7 None None None 78486470 Common - flagellar protein FliS Tcr_2133 20 COG1516 FliS, Flagellin-specific chaperone FliS Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 78485322 Nonpathogen - hypothetical protein Tcr_0978 3 COG1801 COG1801, Uncharacterized conserved protein Function unknown 78486238 Common - acetylglutamate kinase Tcr_1899 221 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 78485048 Common - ribonuclease, Rne/Rng family Tcr_0703 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 78486211 Common - transcriptional regulator, ArsR family Tcr_1872 36 COG0640 ArsR, Predicted transcriptional regulators Transcription 78484849 Common - hypothetical protein Tcr_0504 10 None None None 78485815 Common - flagellar basal-body rod protein FlgB Tcr_1474 83 COG1815 FlgB, Flagellar basal body protein Cell motility and secretion 78486371 Common - acetolactate synthase Tcr_2032 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 78486404 Common - hypothetical protein Tcr_2065 9 None None None 78485829 Common - PfkB Tcr_1488 115 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 78486324 Common - hypothetical protein Tcr_1985 10 None None None 78486092 Common - Peptidase M14, carboxypeptidase A Tcr_1751 20 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 78486273 Common - hypothetical protein Tcr_1934 7 None None None 78485098 Nonpathogen - hypothetical protein Tcr_0753 2 None None None 78485377 Common - electron transport complex, RnfABCDGE type, D subunit Tcr_1033 78 COG4658 RnfD, Predicted NADH:ubiquinone oxidoreductase, subunit RnfD Energy production and conversion 78486264 Common - Molybdate ABC transporter, ATP-binding protein Tcr_1925 249 COG4148 ModC, ABC-type molybdate transport system, ATPase component Inorganic ion transport and metabolism 78485058 Common - acyl carrier protein Tcr_0713 180 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 78485087 Common - flagellar biosynthetic protein FliR Tcr_0742 128 COG1684 FliR, Flagellar biosynthesis pathway, component FliR Cell motility and secretion / Intracellular trafficking and secretion 78484852 Common - glucokinase Tcr_0507 91 COG0837 Glk, Glucokinase Carbohydrate transport and metabolism 78485388 Nonpathogen - hypothetical protein Tcr_1044 1 None None None 78485210 Common - hypothetical protein Tcr_0865 7 None None None 78485398 Common rbgA ribosomal biogenesis GTPase Tcr_1054 98 COG1161 COG1161, Predicted GTPases General function prediction only 78484535 Common - hypothetical protein Tcr_0190 15 None None None 78484482 Common - hypothetical protein Tcr_0137 140 COG2081 COG2081, Predicted flavoproteins General function prediction only 78484923 Nonpathogen - hypothetical protein Tcr_0578 1 None None None 78486233 Nonpathogen - hypothetical protein Tcr_1894 1 None None None 78485998 Common - dimethyladenosine transferase Tcr_1657 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 78484383 Common - Rubredoxin-type Fe(Cys)4 protein Tcr_0037 244 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 78485714 Common - Pseudouridine synthase, RluD Tcr_1370 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 78484475 Common - hypothetical protein Tcr_0130 115 COG4121 COG4121, Uncharacterized conserved protein Function unknown 78486487 Common - YjgF-like protein Tcr_2150 182 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 78484595 Common - type II and III secretion system protein Tcr_0250 130 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 78484860 Common - GreA/GreB family elongation factor Tcr_0515 198 COG0782 GreA, Transcription elongation factor Transcription 78485571 Common - hypothetical protein Tcr_1227 10 COG4399 COG4399, Uncharacterized protein conserved in bacteria Function unknown 78486398 Common - (Acyl-carrier protein) phosphodiesterase Tcr_2059 99 COG1182 AcpD, Acyl carrier protein phosphodiesterase Lipid metabolism 78485176 Common - hypothetical protein Tcr_0831 16 None None None 78485317 Common - ABC transporter related Tcr_0973 249 COG1137 YhbG, ABC-type (unclassified) transport system, ATPase component General function prediction only 78484674 Common - Phage integrase Tcr_0329 16 None None None 78486507 Common - ATP synthase F0, C subunit Tcr_2170 44 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 78484984 Common - type II and III secretion system protein Tcr_0639 137 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 78485191 Common - microcompartments protein Tcr_0846 46 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 78484811 Common - hypothetical protein Tcr_0466 33 None None None 78486102 Common - ABC transporter related Tcr_1761 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 78486163 Common - 5,10-methylenetetrahydrofolate reductase Tcr_1822 143 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 78485247 Nonpathogen - hypothetical protein Tcr_0902 6 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 78484521 Common - hypothetical protein Tcr_0176 15 None None None 78485021 Nonpathogen - hypothetical protein Tcr_0676 1 None None None 78484846 Common - coproporphyrinogen III oxidase Tcr_0501 205 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 78485297 Common - putative D-cysteine desulfhydrase, DcyD Tcr_0953 67 COG2515 Acd, 1-aminocyclopropane-1-carboxylate deaminase Amino acid transport and metabolism 78485505 Common - hypothetical protein Tcr_1161 183 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 78486116 Common - Protein of unknown function DUF692 Tcr_1775 62 COG3220 COG3220, Uncharacterized protein conserved in bacteria Function unknown 78486502 Common - F0F1 ATP synthase subunit beta Tcr_2165 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 78485547 Common - two component transcriptional regulator, winged helix family Tcr_1203 211 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 78485628 Common tsf elongation factor Ts Tcr_1284 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 78485439 Common - response regulator receiver domain protein (CheY-like) Tcr_1095 223 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 78484892 Common - hypothetical protein Tcr_0547 7 COG1416 COG1416, Uncharacterized conserved protein Function unknown 78484806 Common rplM 50S ribosomal protein L13 Tcr_0461 226 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 78484517 Common metH B12-dependent methionine synthase Tcr_0172 178 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 78485425 Common - 4Fe-4S cluster binding Tcr_1081 140 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 78484650 Common - ribosomal protein L14 Tcr_0305 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 78485660 Common - FMN-binding Tcr_1316 9 COG2869 NqrC, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC Energy production and conversion 78486174 Common - Protein of unknown function DUF344 Tcr_1833 127 COG2326 COG2326, Uncharacterized conserved protein Function unknown 78486429 Common - hypothetical protein Tcr_2091 34 None None None 78484790 Common - 3-dehydroquinate dehydratase Tcr_0445 170 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 78485869 Common - poly(A) polymerase Tcr_1528 214 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 78485524 Common - Histone-like DNA-binding protein Tcr_1180 212 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 78486491 Common - Chorismate lyase Tcr_2154 43 COG3161 UbiC, 4-hydroxybenzoate synthetase (chorismate lyase) Coenzyme metabolism 118139519 Common - Ribonuclease R Tcr_1490 200 COG0557 VacB, Exoribonuclease R Transcription 78485431 Common - Small GTP-binding protein domain Tcr_1087 221 COG2262 HflX, GTPases General function prediction only 78485894 Common - Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Tcr_1553 223 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 78485867 Common - 3-methyl-2-oxobutanoate hydroxymethyltransferase Tcr_1526 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 78485611 Nonpathogen - hypothetical protein Tcr_1267 1 None None None 78484464 Common - hypothetical protein Tcr_0119 179 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 78485962 Common - Beta-lactamase-like Tcr_1621 79 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 78485034 Common - Baseplate J-like protein Tcr_0689 35 COG3948 COG3948, Phage-related baseplate assembly protein General function prediction only 78484818 Common - tRNA-i(6)A37 modification enzyme MiaB Tcr_0473 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 78485080 Common - GTP-binding protein Era Tcr_0735 215 COG1159 Era, GTPase General function prediction only 78486044 Common - Acriflavin resistance protein Tcr_1703 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 78484830 Common - Iojap-related protein Tcr_0485 199 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 78485670 Common - Peptidylprolyl isomerase, FKBP-type Tcr_1326 124 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 78486002 Common - integration host factor, alpha subunit Tcr_1661 209 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 78485299 Common - ATP-dependent protease, putative Tcr_0955 95 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 78485127 Common - hypothetical protein Tcr_0782 105 COG1090 COG1090, Predicted nucleoside-diphosphate sugar epimerase General function prediction only 78484782 Common - hypothetical protein Tcr_0437 12 None None None 78484643 Common rplB 50S ribosomal protein L2 Tcr_0298 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 78486304 Common - cytochrome c oxidase, cbb3-type, subunit I Tcr_1965 132 COG3278 CcoN, Cbb3-type cytochrome oxidase, subunit 1 Posttranslational modification, protein turnover, chaperones 78486257 Common - ribosomal protein L28 Tcr_1918 168 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 78486039 Common - Inactivated superfamily I helicase-like Tcr_1698 15 COG3893 COG3893, Inactivated superfamily I helicase DNA replication, recombination, and repair 78485927 Common - MotA/TolQ/ExbB proton channel Tcr_1586 79 COG1291 MotA, Flagellar motor component Cell motility and secretion 78484506 Common - Molybdopterin binding domain MoeA Tcr_0161 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 78485287 Common - Copper-translocating P-type ATPase Tcr_0943 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 78486074 Common - GHMP kinase Tcr_1733 44 COG1577 ERG12, Mevalonate kinase Lipid metabolism 78485282 Common - hypothetical protein Tcr_0938 2 None None None 78484501 Common - Mo-co oxidoreductase dimerisation domain Tcr_0156 81 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 78484951 Nonpathogen - SirA-like Tcr_0606 2 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 78485846 Common - membrane protein-like Tcr_1505 55 COG3164 COG3164, Predicted membrane protein Function unknown 78486334 Common - Protein of unknown function DUF188 Tcr_1995 97 COG1671 COG1671, Uncharacterized protein conserved in bacteria Function unknown 78485132 Nonpathogen - hypothetical protein Tcr_0787 1 None None None 78485778 Common - Flagellar hook-length control protein Tcr_1437 67 COG3144 FliK, Flagellar hook-length control protein Cell motility and secretion 78486436 Nonpathogen - hypothetical protein Tcr_2098 2 None None None 78485899 Common - Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family Tcr_1558 137 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 78485880 Common - 4-hydroxybenzoyl-CoA thioesterase domain protein Tcr_1539 24 COG0824 FcbC, Predicted thioesterase General function prediction only 78486252 Common - PAS/PAC sensor signal transduction histidine kinase Tcr_1913 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 78485621 Common - Outer membrane chaperone Skp (OmpH) Tcr_1277 31 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 78485573 Common - Peptidase M50 Tcr_1229 96 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 78486338 Common - methyl-accepting chemotaxis sensory transducer Tcr_1999 151 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 78486138 Common - Alpha amylase, catalytic region Tcr_1797 145 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 78484379 Common - Sulfonate ABC transporter, periplasmic sulfonate-binding protein, putative Tcr_0033 94 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 78484454 Common - diguanylate cyclase (GGDEF domain) Tcr_0109 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 78486409 Common - hypothetical protein Tcr_2070 186 COG0628 PerM, Predicted permease General function prediction only 78484786 Common - Dihydrouridine synthase TIM-barrel protein nifR3 Tcr_0441 216 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 78486118 Common - Outer membrane efflux protein Tcr_1777 109 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 78485933 Common - recA protein Tcr_1592 229 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 78485737 Common - phospho-2-dehydro-3-heoxyheptonate aldolase Tcr_1393 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 78485260 Common - Phosphatidylglycerophosphatase A Tcr_0915 103 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 78486521 Common - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Tcr_2184 141 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 78485360 Nonpathogen - hypothetical protein Tcr_1016 1 None None None 78486085 Nonpathogen - hypothetical protein Tcr_1744 25 COG0392 COG0392, Predicted integral membrane protein Function unknown 78484657 Common - ribosomal protein S5 Tcr_0312 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 78484445 Common - hypothetical protein Tcr_0100 2 COG2317 COG2317, Zn-dependent carboxypeptidase Amino acid transport and metabolism 78484434 Common - SmtA protein Tcr_0089 102 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 78486342 Common - Pirin-like Tcr_2003 148 COG1741 COG1741, Pirin-related protein General function prediction only 78485204 Common - DNA-directed DNA polymerase Tcr_0859 175 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 78485616 Common - Ribonuclease H Tcr_1272 221 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 78484510 Common - Hpt domain protein Tcr_0165 22 COG2198 ArcB, FOG: HPt domain Signal transduction mechanisms 78484401 Common - VacJ-like lipoprotein Tcr_0055 94 COG2853 VacJ, Surface lipoprotein Cell envelope biogenesis, outer membrane 78484764 Common - YeeE/YedE Tcr_0419 44 None None None 78485554 Common - tRNA-dihydrouridine synthase A Tcr_1210 209 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 78485818 Common - Flageller protein FlgA Tcr_1477 38 COG1261 FlgA, Flagellar basal body P-ring biosynthesis protein Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 78485415 Common - hypothetical protein Tcr_1071 12 None None None 78485156 Common - Ribosomal RNA methyltransferase RrmJ/FtsJ Tcr_0811 138 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 78485251 Common - nitrogen metabolism transcriptional regulator, NtrC, Fis Family Tcr_0906 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 78485443 Common - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Tcr_1099 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 78484394 Common - ResB-like Tcr_0048 59 COG1333 ResB, ResB protein required for cytochrome c biosynthesis Posttranslational modification, protein turnover, chaperones 78486015 Common - Lipopolysaccharide biosynthesis Tcr_1674 19 COG3765 WzzB, Chain length determinant protein Cell envelope biogenesis, outer membrane 78485250 Common - signal transduction histidine kinase, nitrogen specific, NtrB Tcr_0905 196 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 78486353 Common - Chaperone DnaJ-like Tcr_2014 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 78485704 Common - replicative DNA helicase Tcr_1360 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 78486300 Nonpathogen - hypothetical protein Tcr_1961 6 COG5456 COG5456, Predicted integral membrane protein linked to a cation pump Inorganic ion transport and metabolism 78485735 Common - Prepilin peptidase Tcr_1391 135 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 78485595 Common - homoserine dehydrogenase Tcr_1251 217 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 78484443 Common - von Willebrand factor, type A Tcr_0098 70 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 78484602 Common - General secretion pathway protein K Tcr_0257 46 COG3156 PulK, Type II secretory pathway, component PulK Intracellular trafficking and secretion 78484543 Common argS arginyl-tRNA synthetase Tcr_0198 248 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 78485366 Common - selenide, water dikinase Tcr_1022 134 COG0709 SelD, Selenophosphate synthase Amino acid transport and metabolism 78485093 Common - response regulator receiver domain protein (CheY-like) Tcr_0748 223 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 78486504 Common - ATP synthase F1, alpha subunit Tcr_2167 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 78485646 Common - hypothetical protein Tcr_1302 40 COG3647 COG3647, Predicted membrane protein Function unknown 78485958 Nonpathogen - hypothetical protein Tcr_1617 1 None None None 78485265 Common - Peptidyl-prolyl cis-trans isomerase, cyclophilin type Tcr_0920 201 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 78485461 Common - Protein of unknown function DUF485 Tcr_1117 49 COG3162 COG3162, Predicted membrane protein Function unknown 78484979 Common - acetolactate synthase, large subunit, biosynthetic type Tcr_0634 222 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 78484981 Common - ketol-acid reductoisomerase Tcr_0636 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 78484865 Common ectC L-ectoine synthase Tcr_0520 35 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 78485496 Common - nitrate transporter, putative Tcr_1152 80 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 78484916 Common - prolipoprotein diacylglyceryl transferase Tcr_0571 210 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 78484725 Common - diguanylate cyclase (GGDEF domain) Tcr_0380 130 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 78485359 Common - DEAD/DEAH box helicase-like Tcr_1015 234 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 78484933 Common lpxC UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase Tcr_0588 139 COG0774 LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase Cell envelope biogenesis, outer membrane 78485964 Common - Biopolymer transport protein ExbD/TolR Tcr_1623 58 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 78486465 Common - Uncharacterized FlgJ-related protein-like Tcr_2128 31 COG2992 Bax, Uncharacterized FlgJ-related protein General function prediction only 78484696 Common anmK anhydro-N-acetylmuramic acid kinase Tcr_0351 120 COG2377 COG2377, Predicted molecular chaperone distantly related to HSP70-fold metalloproteases Posttranslational modification, protein turnover, chaperones 78484593 Common - fructose-1,6-bisphosphate aldolase Tcr_0248 176 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 78486086 Common - Glycosyl transferase, family 9 Tcr_1745 62 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 78484842 Nonpathogen - hypothetical protein Tcr_0497 1 COG0579 COG0579, Predicted dehydrogenase General function prediction only 78485122 Common - methyl-accepting chemotaxis sensory transducer Tcr_0777 160 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 78485121 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Tcr_0776 179 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 78486377 Common - hydrogenase (NiFe) small subunit (hydA) Tcr_2038 206 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 78484909 Common - UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase Tcr_0564 210 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 78484994 Common - tRNA (guanine-N1)-methyltransferase Tcr_0649 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 78486244 Common - Phosphomannomutase Tcr_1905 239 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 78486141 Common - NLPA lipoprotein Tcr_1800 60 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 78486168 Common - Protein of unknown function DUF179 Tcr_1827 128 COG1678 COG1678, Putative transcriptional regulator Transcription 78486526 Common - periplasmic sensor signal transduction histidine kinase Tcr_2189 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 78484548 Common - hypothetical protein Tcr_0203 61 COG2836 COG2836, Uncharacterized conserved protein Function unknown 78484970 Common - Small GTP-binding protein domain Tcr_0625 230 COG1160 COG1160, Predicted GTPases General function prediction only 78485536 Common - phosphoserine aminotransferase Tcr_1192 111 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 78485802 Common - DegT/DnrJ/EryC1/StrS aminotransferase Tcr_1461 191 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 78485434 Common - HflK protein Tcr_1090 194 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 78486135 Common - Sucrose-phosphate synthase Tcr_1794 131 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 78485356 Nonpathogen - hypothetical protein Tcr_1012 1 None None None 78485603 Common - Septum formation initiator Tcr_1259 33 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 78486381 Common - hydrogenase assembly chaperone hypC/hupF Tcr_2042 98 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 78485458 Common aat leucyl/phenylalanyl-tRNA--protein transferase Tcr_1114 134 COG2360 Aat, Leu/Phe-tRNA-protein transferase Posttranslational modification, protein turnover, chaperones 78486196 Common - Cation efflux protein Tcr_1855 119 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 78484648 Common - ribosomal protein L29 Tcr_0303 161 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 78485060 Common - hypothetical protein Tcr_0715 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 78485590 Nonpathogen - hypothetical protein Tcr_1246 1 None None None 78485951 Nonpathogen - hypothetical protein Tcr_1610 9 None None None 78484360 Common - hypothetical protein Tcr_0014 53 COG1808 COG1808, Predicted membrane protein Function unknown 78484495 Nonpathogen - hypothetical protein Tcr_0150 1 None None None 78485474 Common - Peptidase M16-like Tcr_1130 111 COG1026 COG1026, Predicted Zn-dependent peptidases, insulinase-like General function prediction only 78485110 Common - outer membrane lipoprotein carrier protein LolA Tcr_0765 84 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 78486533 Nonpathogen - hypothetical protein Tcr_2196 1 None None None 78486380 Common - hydrogenase expression/formation protein HypD Tcr_2041 108 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 78485988 Common - transposase Tcr_1647 53 None None None 78484689 Common - gamma-glutamyl kinase Tcr_0344 193 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 78485791 Common - hypothetical protein Tcr_1450 6 COG1334 FlaG, Uncharacterized flagellar protein FlaG Cell motility and secretion 78485181 Nonpathogen - hypothetical protein Tcr_0836 1 None None None 78485763 Nonpathogen - hypothetical protein Tcr_1420 5 None None None 78485258 Common - Phosphatidylserine decarboxylase Tcr_0913 92 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 78484710 Nonpathogen - hypothetical protein Tcr_0365 1 None None None 78486059 Common - isopentenyl pyrophosphate isomerase Tcr_1718 80 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 78485275 Common - DNA polymerase III, epsilon subunit Tcr_0930 187 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 78485837 Common - Inorganic diphosphatase Tcr_1496 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 78485632 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Tcr_1288 19 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 78485073 Common - CheW protein Tcr_0728 118 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 78484731 Common - OmpA/MotB Tcr_0386 146 COG1360 MotB, Flagellar motor protein Cell motility and secretion 78485938 Common - glutathione synthetase Tcr_1597 140 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 78486107 Nonpathogen - hypothetical protein Tcr_1766 3 None None None 78485349 Common - hypothetical protein Tcr_1005 16 COG4938 COG4938, Uncharacterized conserved protein Function unknown 78486153 Common - dihydroneopterin aldolase Tcr_1812 131 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 78485014 Common - Exonuclease Tcr_0669 9 None None None 118139522 Common - Phage tail protein X Tcr_2203 4 COG5004 COG5004, P2-like prophage tail protein X General function prediction only 78485234 Common - Protein of unknown function DUF502 Tcr_0889 83 COG2928 COG2928, Uncharacterized conserved protein Function unknown 78486312 Common - twin-arginine translocation protein TatB Tcr_1973 15 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 78484425 Common - methyltransferase Tcr_0079 65 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 78486028 Common - NAD-dependent epimerase/dehydratase Tcr_1687 232 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 78484964 Common - Nucleoside-diphosphate kinase Tcr_0619 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 78486453 Common - Copper resistance B precursor Tcr_2115 42 COG3667 PcoB, Uncharacterized protein involved in copper resistance Inorganic ion transport and metabolism 78484519 Common - Protein of unknown function DUF81 Tcr_0174 93 COG0730 COG0730, Predicted permeases General function prediction only 78484738 Common - ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5 Tcr_0393 191 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 78485581 Common - hypothetical protein Tcr_1237 18 None None None 78485627 Common - Uridylate kinase Tcr_1283 232 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 78486200 Common - outer membrane protein, probably efflux family Tcr_1861 20 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 78486535 Common - ribonuclease P protein component Tcr_2198 79 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 78484664 Common - DNA-directed RNA polymerase subunit alpha Tcr_0319 217 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 78485468 Common - ribosome-binding factor A Tcr_1124 179 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 78484356 Common - hypothetical protein Tcr_0010 25 COG2930 COG2930, Uncharacterized conserved protein Function unknown 78485046 Nonpathogen - hypothetical protein Tcr_0701 1 None None None 78485169 Common - Respiratory-chain NADH dehydrogenase, subunit 1 Tcr_0824 187 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 78486361 Common - Heat shock protein Hsp20 Tcr_2022 151 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 78486033 Common - glucosamine--fructose-6-phosphate aminotransferase, isomerizing Tcr_1692 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 78485747 Common - putative ABC transporter ATP-binding protein Tcr_1403 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 78485382 Common - anti-sigma-factor antagonist (STAS) domain protein Tcr_1038 15 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 78485636 Common - cyclic nucleotide-binding domain (cNMP-BD) protein Tcr_1292 23 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 78486415 Common - Integrase, catalytic region Tcr_2076 143 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 78484503 Common - molybdenum cofactor synthesis-like Tcr_0158 198 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism