Escherichia coli O157:H7 EDL933 plasmid pO157, complete sequence NC_007414 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 75994480 Common etpE type II secretion protein L7034 224 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 75994498 Common - hypothetical protein L7052 14 COG1846 MarR, Transcriptional regulators Transcription 75994491 Common - hypothetical protein L7045 57 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75994518 Common - hypothetical protein L7072 91 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 75994508 Pathogen ccdA plasmid maintenance protein L7062 5 COG5302 COG5302, Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid General function prediction only 75994522 Pathogen - hypothetical protein L7076 5 None None None 75994460 Common - hypothetical protein L7014 146 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 161367664 Common - replication protein L7056 7 None None None 75994455 Common rep2 replication initiation protein L7008 8 None None None 75994529 Pathogen - hypothetical protein L7083 1 None None None 75994471 Pathogen - hypothetical protein L7025 1 None None None 75994535 Pathogen flmC hypothetical protein L7089 1 None None None 75994485 Common etpJ type II secretion protein L7039 38 COG4795 PulJ, Type II secretory pathway, component PulJ Intracellular trafficking and secretion 75994538 Common - hypothetical protein L7092 10 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 75994544 Common traI DNA helicase L7098 24 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 75994545 Common traX F pilin acetylase L7099 11 None None None 75994448 Common finO fertility inhibition protein L7001 7 COG3109 ProQ, Activator of osmoprotectant transporter ProP Signal transduction mechanisms 75994496 Common EHEC-hlyD hemolysin transport protein L7050 123 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 75994524 Pathogen - hypothetical protein L7078 2 None None None 75994467 Pathogen - hypothetical protein L7021 1 None None None 75994506 Common - hypothetical protein L7060 4 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 75994542 Common - putative transposase L7096 26 None None None 75994465 Common - transposase L7019 148 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75994453 Pathogen cpb2 protein CopB L7006 5 None None None 75994488 Common etpM type II secretion protein L7042 13 COG3149 PulM, Type II secretory pathway, component PulM Intracellular trafficking and secretion 75994459 Pathogen - hypothetical protein L7012 1 None None None 75994526 Pathogen - hypothetical protein L7080 1 None None None 75994514 Common sopA plasmid-partitioning protein L7068 203 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 75994495 Common EHEC-hlyB hemolysin transport protein L7049 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 161367665 Common - hypothetical protein L7086 85 COG1475 Spo0J, Predicted transcriptional regulators Transcription 75994463 Common katP EHEC-catalase/peroxidase L7017 98 COG0376 KatG, Catalase (peroxidase I) Inorganic ion transport and metabolism 75994475 Common - lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase L7029 88 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 75994479 Common etpD type II secretion protein L7033 141 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 75994531 Common - hypothetical protein L7085 4 None None None 75994505 Common - hypothetical protein L7059 2 None None None 75994534 Common psiA hypothetical protein L7088 4 None None None 75994486 Common etpK type II secretion protein L7040 41 COG3156 PulK, Type II secretory pathway, component PulK Intracellular trafficking and secretion 75994468 Common insA transposase L7022 15 COG3677 COG3677, Transposase and inactivated derivatives DNA replication, recombination, and repair 75994457 Common - hypothetical protein L7010 13 COG3905 COG3905, Predicted transcriptional regulator Transcription 75994509 Common ccdB plasmid maintenance protein L7063 8 None None None 75994490 Pathogen etpO type II secretion protein L7044 4 None None None 75994493 Common EHEC-hlyC hemolysin transport protein L7047 15 COG2994 HlyC, ACP:hemolysin acyltransferase (hemolysin-activating protein) Posttranslational modification, protein turnover, chaperones 75994516 Pathogen - hypothetical protein L7070 1 None None None 75994473 Common - hypothetical protein L7027 216 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 75994461 Common - transposase L7015 17 None None None 75994510 Common redF resolvase L7064 173 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 75994528 Common - hypothetical protein L7082 25 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 75994483 Pathogen etpH type II secretion protein L7037 4 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 75994477 Common - hypothetical protein L7031 7 None None None 75994530 Common ssb single-stranded DNA-binding protein L7084 213 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 75994484 Common etpI type II secretion protein L7038 30 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 75994537 Common - putative nickase L7091 8 None None None 75994546 Common ypt2 hypothetical protein L7100 87 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 75994543 Common - hypothetical protein L7097 93 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 75994470 Common - regulatory protein L7024 6 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 75994449 Pathogen - hypothetical protein L7002 2 None None None 75994499 Pathogen - putative serine-threonine protein kinase L7053 1 None None None 75994519 Pathogen - hypothetical protein L7073 6 None None None 75994517 Pathogen - hypothetical protein L7071 1 None None None 75994512 Common - hypothetical protein L7066 30 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75994521 Common - hypothetical protein L7075 6 None None None 75994504 Common - hypothetical protein L7058 7 None None None 75994454 Pathogen - replication initiation protein L7007 2 None None None 75994541 Common - putative cytotoxin L7095 5 None None None 75994450 Common - hypothetical protein L7003 90 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 75994513 Pathogen - rep protein E1 L7067 2 COG5527 COG5527, Protein involved in initiation of plasmid replication DNA replication, recombination, and repair 75994481 Common etpF type II secretion protein L7035 146 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 75994500 Common - replication protein L7054 23 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 75994536 Common flmA small toxic polypeptide L7090 5 None None None 75994494 Common EHEC-hlyA hemolysin toxin protein L7048 68 COG2931 COG2931, RTX toxins and related Ca2+-binding proteins Secondary metabolites biosynthesis, transport, and catabolism 75994497 Pathogen - hypothetical protein L7051 1 None None None 75994507 Pathogen - hypothetical protein L7061 1 None None None 75994452 Pathogen - hypothetical protein L7005 2 None None None 75994523 Common - hypothetical protein L7077 13 None None None 75994466 Common espP putative exoprotein-precursor L7020 29 COG4625 COG4625, Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain Function unknown 75994464 Pathogen - hypothetical protein L7018 1 COG3783 CybC, Soluble cytochrome b562 Energy production and conversion 75994489 Common etpN type II secretion protein L7043 135 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 75994501 Pathogen - replication protein L7055 1 None None None 75994533 Common psb1 putative regulator of SOS induction L7087 4 None None None 75994540 Common - transposase L7094 14 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 75994474 Common - hypothetical protein L7028 60 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 75994520 Common - hypothetical protein L7074 115 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 75994478 Common etpC type II secretion protein L7032 17 COG3031 PulC, Type II secretory pathway, component PulC Intracellular trafficking and secretion 75994469 Pathogen - hypothetical protein L7023 1 None None None 75994525 Pathogen - hypothetical protein L7079 1 None None None 75994451 Common - putative hemolysin expression-modulating protein L7004 12 None None None 75994458 Common - hypothetical protein L7011 13 COG3668 ParE, Plasmid stabilization system protein General function prediction only 75994492 Common - hypothetical protein L7046 143 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75994511 Common tra6 transposase L7065 149 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75994472 Common - hypothetical protein L7026 96 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 75994539 Common - putative transposase L7093 63 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75994487 Common etpL type II secretion protein L7041 25 COG3297 PulL, Type II secretory pathway, component PulL Intracellular trafficking and secretion 75994482 Common etpG type II secretion protein L7036 103 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 75994503 Pathogen - replication protein L7057 2 None None None 75994462 Pathogen - hypothetical protein L7016 2 None None None 75994476 Pathogen - hypothetical protein L7030 1 None None None 75994456 Pathogen - replication protein L7009 1 None None None 75994527 Common - hypothetical protein L7081 12 None None None 75994515 Common sopB plasmid partitioning protein L7069 18 COG1475 Spo0J, Predicted transcriptional regulators Transcription