Nitrobacter winogradskyi Nb-255, complete genome NC_007406 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 75676576 Common - imidazole glycerol phosphate synthase, glutamine amidotransferase subunit Nwi_2391 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 75675377 Nonpathogen - hypothetical protein Nwi_1184 1 None None None 75677207 Common - trehalose-phosphatase Nwi_3026 74 COG1877 OtsB, Trehalose-6-phosphatase Carbohydrate transport and metabolism 75677191 Nonpathogen - hypothetical protein Nwi_3010 1 None None None 75676096 Common - hypothetical protein Nwi_1905 133 COG0628 PerM, Predicted permease General function prediction only 75676465 Common - OsmC-like protein Nwi_2280 66 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 75674738 Nonpathogen - hypothetical protein Nwi_0540 1 None None None 75674789 Common - sulfite reductase (NADPH) hemoprotein, beta subunit Nwi_0591 152 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 75676186 Nonpathogen - hypothetical protein Nwi_1996 1 None None None 75676930 Common - ABC transporter, ATP-binding/permease protein Nwi_2746 248 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 75674886 Common - pyrroloquinoline quinone biosynthesis protein PqqE Nwi_0689 141 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 75677103 Common - ISBm1, transposase orfA Nwi_2922 78 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676358 Nonpathogen - hypothetical protein Nwi_2173 3 None None None 75674227 Common - polynucleotide phosphorylase/polyadenylase Nwi_0028 242 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 75675146 Common - Protein of unknown function DUF196 Nwi_0953 21 COG3512 COG3512, Uncharacterized protein conserved in bacteria Function unknown 75674367 Nonpathogen - hypothetical protein Nwi_0168 1 None None None 75676300 Common groES co-chaperonin GroES Nwi_2114 216 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 75676700 Common - ornithine aminotransferase Nwi_2516 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 75674378 Common - PTS IIA-like nitrogen-regulatory protein PtsN Nwi_0179 131 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 75674902 Common - TonB protein Nwi_0705 14 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 75675679 Common - phage integrase Nwi_1487 83 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 75675649 Common - heavy metal efflux pump CzcA Nwi_1457 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 75676387 Common - VWA containing CoxE-like Nwi_2202 38 COG3552 CoxE, Protein containing von Willebrand factor type A (vWA) domain General function prediction only 75674862 Common - Branched-chain amino acid ABC-type transport system permease components Nwi_0665 150 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 75676000 Common - deoxyguanosinetriphosphate triphosphohydrolase Nwi_1808 159 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 75674437 Common - F0F1 ATP synthase subunit A Nwi_0238 142 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 75675022 Common - transcriptional regulator, XRE family Nwi_0826 9 COG1396 HipB, Predicted transcriptional regulators Transcription 75675757 Common - phage integrase Nwi_1565 113 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 75675392 Common - glutamate-ammonia ligase adenylyltransferase Nwi_1199 119 COG1391 GlnE, Glutamine synthetase adenylyltransferase Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms 75676558 Nonpathogen - hypothetical protein Nwi_2373 2 None None None 75676083 Common - Histone-like DNA-binding protein Nwi_1892 195 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 75676412 Common - ROSMUCR transcriptional regulator Nwi_2227 34 COG4957 COG4957, Predicted transcriptional regulator Transcription 75676768 Nonpathogen - hypothetical protein Nwi_2584 3 None None None 75677008 Common - transposase, IS4 Nwi_2824 62 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675323 Common fliP flagellar biosynthesis protein FliP Nwi_1130 128 COG1338 FliP, Flagellar biosynthesis pathway, component FliP Cell motility and secretion / Intracellular trafficking and secretion 75676334 Common - hypothetical protein Nwi_2149 35 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 75676159 Common - ISRm2011-2 transposase protein Nwi_1968 40 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75677050 Common - hypothetical protein Nwi_2869 14 None None None 75677181 Common - hypothetical protein Nwi_3000 41 COG4949 COG4949, Uncharacterized membrane-anchored protein conserved in bacteria Function unknown 75676453 Common - hypothetical protein Nwi_2268 27 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 75675652 Common - hypothetical protein Nwi_1460 80 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 75675034 Nonpathogen - hypothetical protein Nwi_0839 1 None None None 75676404 Common - TonB-dependent receptor Nwi_2219 124 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 75676773 Common - peptidase S49 Nwi_2589 181 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 75676644 Common - Protein of unknown function DUF1458 Nwi_2460 25 COG3360 COG3360, Uncharacterized conserved protein Function unknown 75675364 Common - peptidase S1 and S6, chymotrypsin/Hap Nwi_1171 8 COG5640 COG5640, Secreted trypsin-like serine protease Posttranslational modification, protein turnover, chaperones 75675600 Common - integration host factor, alpha subunit Nwi_1408 194 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 75677015 Common - hypothetical protein Nwi_2831 7 COG5471 COG5471, Uncharacterized conserved protein Function unknown 75674953 Nonpathogen - hypothetical protein Nwi_0757 1 None None None 75676968 Nonpathogen - hypothetical protein Nwi_2784 1 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 75676834 Nonpathogen - cytochrome c, class I Nwi_2650 5 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 75675841 Nonpathogen - hypothetical protein Nwi_1649 3 None None None 75676032 Common - LexA repressor Nwi_1841 168 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 75675051 Common - Prevent-host-death protein Nwi_0856 18 COG2161 StbD, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 75674749 Nonpathogen - hypothetical protein Nwi_0551 1 None None None 75675321 Nonpathogen - hypothetical protein Nwi_1128 1 None None None 75674977 Nonpathogen - transposase (class I) Nwi_0781 5 None None None 75674410 Common - Heat shock protein Hsp20 Nwi_0211 65 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 75676896 Nonpathogen - hypothetical protein Nwi_2712 3 None None None 75674891 Common - cytochrome c Hsc Nwi_0694 39 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 75674816 Common - extensin-like protein Nwi_0618 36 COG3921 COG3921, Uncharacterized protein conserved in bacteria Function unknown 75675340 Nonpathogen - hypothetical protein Nwi_1147 4 None None None 75675968 Common - seryl-tRNA synthetase Nwi_1776 244 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 75676624 Common - RNA polymerase sigma factor RpoD Nwi_2440 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 75675260 Common - histidinol-phosphate phosphatase Nwi_1067 128 COG0241 HisB, Histidinol phosphatase and related phosphatases Amino acid transport and metabolism 75676979 Common - 3-isopropylmalate dehydrogenase Nwi_2795 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 75674537 Common modB molybdate ABC transporter permease protein Nwi_0339 226 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 75677044 Nonpathogen - hypothetical protein Nwi_2863 3 None None None 75674525 Common - ABC transporter, transmembrane region Nwi_0327 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 75675078 Common - dihydrodipicolinate synthetase Nwi_0883 229 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 75676951 Common - Protein of unknown function DUF883, ElaB Nwi_2767 6 COG4575 ElaB, Uncharacterized conserved protein Function unknown 75674302 Common - Maf-like protein Nwi_0103 176 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 75677275 Common - hypothetical protein Nwi_3097 9 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 75676904 Common - MotA/TolQ/ExbB proton channel Nwi_2720 147 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 75675258 Common - UDP-glucose 4-epimerase Nwi_1065 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 75676958 Common - HWE histidine kinase Nwi_2774 29 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 75674400 Common - dihydrodipicolinate reductase Nwi_0201 217 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 75677081 Common - hypothetical protein Nwi_2900 22 None None None 75676761 Nonpathogen - hypothetical protein Nwi_2577 3 None None None 75674564 Common - integrase, catalytic region Nwi_0366 57 None None None 75674966 Common - cytochrome c oxidase, subunit I Nwi_0770 164 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 75677291 Common - transposase IS3/IS911 Nwi_3113 30 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674288 Common - hypothetical protein Nwi_0089 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 75675883 Common rpsF 30S ribosomal protein S6 Nwi_1691 182 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 75676982 Common - succinate dehydrogenase, cytochrome b subunit Nwi_2798 80 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 75674309 Common - Histidine kinase Nwi_0110 174 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 75674774 Common - ABC transporter, ATPase subunit Nwi_0576 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 75675897 Nonpathogen - hypothetical protein Nwi_1705 4 None None None 75675338 Common - Protein of unknown function DUF1452 Nwi_1145 26 COG5478 COG5478, Predicted small integral membrane protein Function unknown 75676855 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding Nwi_2671 34 COG3871 COG3871, Uncharacterized stress protein (general stress protein 26) General function prediction only 75674278 Common - 2-octaprenyl-6-methoxyphenyl hydroxylase Nwi_0079 129 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 75674453 Common - antirestriction protein Nwi_0255 48 COG4227 COG4227, Antirestriction protein DNA replication, recombination, and repair 75674646 Common - peptidase M23B Nwi_0448 146 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 75676047 Common - ribosome recycling factor Nwi_1856 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 75674913 Common - thioredoxin-like protein Nwi_0716 146 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 75674682 Common - inorganic pyrophosphatase Nwi_0484 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 75675860 Common - tyrosyl-tRNA synthetase Nwi_1668 216 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 75676603 Nonpathogen - hypothetical protein Nwi_2418 12 COG5615 COG5615, Predicted integral membrane protein Function unknown 75674992 Common - Conserved hypothetical protein 2217 Nwi_0796 25 COG5448 COG5448, Uncharacterized conserved protein Function unknown 75674516 Common - Periplasmic protein thiol-disulfide oxidoreductase DsbE Nwi_0318 156 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 75675155 Common - type I secretion system ATPase, PrtD Nwi_0962 249 COG4618 ArpD, ABC-type protease/lipase transport system, ATPase and permease components General function prediction only 75674266 Common rplT 50S ribosomal protein L20 Nwi_0067 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 75677297 Common - putative DNA-binding protein Nwi_3119 61 COG3943 COG3943, Virulence protein General function prediction only 75674671 Common - hypothetical protein Nwi_0473 12 COG4223 COG4223, Uncharacterized protein conserved in bacteria Function unknown 75675132 Common - hypothetical protein Nwi_0939 12 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 75676837 Common - hypothetical protein Nwi_2653 144 COG1959 COG1959, Predicted transcriptional regulator Transcription 75675918 Common - hypothetical protein Nwi_1726 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 75674740 Common - hypothetical protein Nwi_0542 7 None None None 75675794 Nonpathogen - hypothetical protein Nwi_1602 1 None None None 75676480 Common - GCN5-related N-acetyltransferase Nwi_2295 76 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 75676928 Common - hypothetical protein Nwi_2744 150 COG1360 MotB, Flagellar motor protein Cell motility and secretion 75676234 Common - hypothetical protein Nwi_2044 5 None None None 75676133 Common - putative bacteriophage-related protein Nwi_1942 20 None None None 75675696 Common - Zinc-containing alcohol dehydrogenase superfamily Nwi_1504 178 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 75676009 Common - pyruvate dehydrogenase subunit beta Nwi_1817 211 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 75676974 Common - Protein of unknown function DUF1025 Nwi_2790 43 COG3824 COG3824, Uncharacterized protein conserved in bacteria Function unknown 75676489 Nonpathogen - hypothetical protein Nwi_2304 1 None None None 75675187 Nonpathogen - hypothetical protein Nwi_0994 3 None None None 75675804 Nonpathogen - hypothetical protein Nwi_1612 3 None None None 75674423 Common - cytochrome c oxidase, subunit I Nwi_0224 163 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 75676417 Common - hypothetical protein Nwi_2232 12 None None None 75674362 Common - 2-dehydropantoate 2-reductase Nwi_0163 81 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 75676374 Common - molybdopterin-biosynthesis enzyme MoeA Nwi_2189 166 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 75676706 Common - N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase Nwi_2522 223 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 75675983 Common - hypothetical protein Nwi_1791 2 None None None 75675466 Common - peptidase C14, caspase catalytic subunit p20 Nwi_1274 20 COG4249 COG4249, Uncharacterized protein containing caspase domain General function prediction only 75674722 Common - MCP methyltransferase, CheR-type Nwi_0524 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 75675750 Nonpathogen - hypothetical protein Nwi_1558 1 None None None 75675349 Common - ISSpo8, transposase Nwi_1156 33 COG3677 COG3677, Transposase and inactivated derivatives DNA replication, recombination, and repair 75677122 Common - helix-turn-helix, Fis-type Nwi_2941 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676272 Common - divergent AAA region Nwi_2084 8 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 75675525 Nonpathogen - Hpt protein Nwi_1333 7 None None None 75676690 Nonpathogen - hypothetical protein Nwi_2506 3 None None None 75674590 Common - acetyl-CoA carboxylase carboxyltransferase subunit alpha Nwi_0392 175 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 75674936 Nonpathogen - hypothetical protein Nwi_0739 2 None None None 75674643 Common nadD nicotinic acid mononucleotide adenyltransferase Nwi_0445 85 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 75677307 Nonpathogen - hypothetical protein Nwi_3129 8 None None None 75676529 Common - tRNA isopentenyltransferase Nwi_2344 214 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 75676490 Common - MotA/TolQ/ExbB proton channel Nwi_2305 127 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 75677061 Common - transposase IS3/IS911 Nwi_2880 33 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676306 Common - integrase, catalytic region Nwi_2120 141 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674574 Common - modification methylase HemK Nwi_0376 216 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 75674529 Common - perplasmic binding protein of ABC transporter Nwi_0331 51 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 75675221 Common fixJ response regulator FixJ Nwi_1028 220 COG4566 TtrR, Response regulator Signal transduction mechanisms 75674629 Common - F0F1 ATP synthase subunit gamma Nwi_0431 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 75676589 Nonpathogen - hypothetical protein Nwi_2404 1 None None None 75675962 Common - Preprotein translocase subunit, YajC Nwi_1770 169 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 75677317 Common - Metal-dependent phosphohydrolase Nwi_3139 119 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 75676794 Common - Protein of unknown function DUF454 Nwi_2610 86 COG2832 COG2832, Uncharacterized protein conserved in bacteria Function unknown 75676665 Common - trans-aconitate methyltransferase Nwi_2481 85 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 75675609 Nonpathogen - hypothetical protein Nwi_1417 4 None None None 75676472 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Nwi_2287 229 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 75675206 Nonpathogen - hypothetical protein Nwi_1013 9 COG5490 COG5490, Uncharacterized conserved protein Function unknown 75675786 Common - polyphosphate kinase Nwi_1594 161 COG0855 Ppk, Polyphosphate kinase Inorganic ion transport and metabolism 162139842 Common recO DNA repair protein RecO Nwi_1915 63 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 75675311 Nonpathogen - hypothetical protein Nwi_1118 2 None None None 75675428 Common - CDP-diacylglycerol--serine O-phosphatidyltransferase Nwi_1235 152 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 75675640 Common - D-amino acid aminotransferase Nwi_1448 187 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 75675911 Common - cell wall hydrolase/autolysin Nwi_1719 176 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 75674370 Common - 3'-5' exonuclease Nwi_0171 117 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 75675835 Common - elongation factor P Nwi_1643 214 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 75676699 Common - aldehyde dehydrogenase Nwi_2515 221 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 75676016 Nonpathogen - PE_PGRS family protein Nwi_1824 1 None None None 75676075 Nonpathogen - methyltransferase FkbM Nwi_1884 4 None None None 75674715 Common - hypothetical protein Nwi_0517 19 None None None 75676501 Common - hypothetical protein Nwi_2316 21 COG4244 COG4244, Predicted membrane protein Function unknown 75676921 Common - fructose-bisphosphate aldolase, class-I Nwi_2737 33 COG3588 COG3588, Fructose-1,6-bisphosphate aldolase Carbohydrate transport and metabolism 75675596 Common - ubiquinol-cytochrome C chaperone Nwi_1404 23 COG5452 COG5452, Uncharacterized conserved protein Function unknown 75677129 Common - transposase Nwi_2948 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676144 Common - putative DNA modification methylase Nwi_1953 5 None None None 75675372 Common - hypothetical protein Nwi_1179 30 COG5449 COG5449, Uncharacterized conserved protein Function unknown 75675736 Common - Phage portal protein, HK97 Nwi_1544 69 COG4695 COG4695, Phage-related protein Function unknown 75676317 Common - DEAD/DEAH box helicase Nwi_2131 18 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 75675116 Common - GCN5-related N-acetyltransferase Nwi_0923 31 COG3153 COG3153, Predicted acetyltransferase General function prediction only 75675816 Nonpathogen - hypothetical protein Nwi_1624 4 None None None 75675401 Common - alpha amylase Nwi_1208 169 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 75674729 Common - hypothetical protein Nwi_0531 10 None None None 75676755 Nonpathogen - hypothetical protein Nwi_2571 10 COG3143 CheZ, Chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 75675810 Nonpathogen - hypothetical protein Nwi_1618 2 None None None 75676351 Common - Protein of unknown function DUF1491 Nwi_2166 25 COG5447 COG5447, Uncharacterized conserved protein Function unknown 75676842 Common phaF putative monovalent cation/H+ antiporter subunit F Nwi_2658 67 COG2212 MnhF, Multisubunit Na+/H+ antiporter, MnhF subunit Inorganic ion transport and metabolism 75676041 Common lpxD UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase Nwi_1850 188 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 75675729 Nonpathogen - hypothetical protein Nwi_1537 2 None None None 75674579 Common - 3-demethylubiquinone-9 3-methyltransferase Nwi_0381 128 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 75674586 Common argJ bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein Nwi_0388 167 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 75676743 Common - inositol monophosphatase Nwi_2559 182 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 75676116 Common - uracil-DNA glycosylase superfamily Nwi_1925 83 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 75676810 Common - ATPase associated with various cellular activities, AAA_3 Nwi_2626 173 COG0714 COG0714, MoxR-like ATPases General function prediction only 75676365 Nonpathogen - hypothetical protein Nwi_2180 6 None None None 75675318 Nonpathogen - hypothetical protein Nwi_1125 6 None None None 75676629 Common - hypothetical protein Nwi_2445 151 COG1610 COG1610, Uncharacterized conserved protein Function unknown 75674388 Common - heat shock protein HtpX Nwi_0189 196 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 75677080 Common - integrase, catalytic region Nwi_2899 62 None None None 75675985 Nonpathogen - hypothetical protein Nwi_1793 4 None None None 75674254 Common - tryptophan synthase subunit beta Nwi_0055 224 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 75675614 Common rpsI 30S ribosomal protein S9 Nwi_1422 247 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 75675599 Common - 3-oxoacyl-(acyl carrier protein) synthase III Nwi_1407 211 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 75676208 Common - GCN5-related N-acetyltransferase Nwi_2018 22 None None None 75675196 Nonpathogen - Protein of unknown function DUF465 Nwi_1003 6 COG5481 COG5481, Uncharacterized conserved small protein containing a coiled-coil domain Function unknown 75675848 Common - peptidase C14, caspase catalytic subunit p20 Nwi_1656 25 COG4249 COG4249, Uncharacterized protein containing caspase domain General function prediction only 75674909 Common - cytochrome c, class I Nwi_0712 57 COG3474 COG3474, Cytochrome c2 Energy production and conversion 75675669 Common - phage protein, HK97, gp10 Nwi_1477 6 None None None 75674733 Common - ABC transporter, transmembrane region Nwi_0535 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 75676205 Common - DNA repair protein RadA Nwi_2015 210 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 75675666 Nonpathogen - per-hexamer repeat gene protein Nwi_1474 2 None None None 75676884 Common - NUDIX hydrolase Nwi_2700 119 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 75674622 Nonpathogen - hypothetical protein Nwi_0424 1 None None None 75676613 Common - hypothetical protein Nwi_2428 33 None None None 75676426 Common - peptidase C15, pyroglutamyl peptidase I Nwi_2241 25 COG2039 Pcp, Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase) Posttranslational modification, protein turnover, chaperones 75675059 Common - beta-lactamase-like Nwi_0864 10 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 75675935 Nonpathogen - hypothetical protein Nwi_1743 3 None None None 75675459 Common - MotA/TolQ/ExbB proton channel Nwi_1267 127 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 75676565 Common - UDP-glucose/GDP-mannose dehydrogenase Nwi_2380 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 75676986 Common - OmpA/MotB Nwi_2802 52 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 75675563 Common rplP 50S ribosomal protein L16 Nwi_1371 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 75675410 Common - TRAP C4-dicarboxylate transport system permease DctM subunit Nwi_1217 126 COG4664 FcbT3, TRAP-type mannitol/chloroaromatic compound transport system, large permease component Secondary metabolites biosynthesis, transport, and catabolism 75676932 Common - Protein of unknown function DUF1465 Nwi_2748 19 COG5317 COG5317, Uncharacterized protein conserved in bacteria Function unknown 75674509 Common - Cold-shock protein, DNA-binding Nwi_0311 177 COG1278 CspC, Cold shock proteins Transcription 75675584 Common - recombination factor protein RarA Nwi_1392 228 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 75677256 Common - Signal transduction histidine kinase Nwi_3077 151 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 75675244 Common murG N-acetylglucosaminyl transferase Nwi_1051 208 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 75676527 Common ilvH acetolactate synthase 3 regulatory subunit Nwi_2342 189 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 75677100 Common - transposase, IS4 Nwi_2919 66 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674458 Common - hypothetical protein Nwi_0260 7 None None None 75676267 Common - transcriptional regulator, XRE family Nwi_2078 13 None None None 75676802 Common - tRNA/rRNA methyltransferase (SpoU) Nwi_2618 157 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 75674252 Common - acetyl-CoA carboxylase subunit beta Nwi_0053 218 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 75674522 Common - Protein of unknown function DUF1223 Nwi_0324 33 COG5429 COG5429, Uncharacterized secreted protein Function unknown 75674273 Common - peptidase S16 Nwi_0074 87 COG2802 COG2802, Uncharacterized protein, similar to the N-terminal domain of Lon protease General function prediction only 75674427 Common - cytochrome c oxidase, subunit III Nwi_0228 157 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 75676101 Common - hypothetical protein Nwi_1910 21 COG1714 COG1714, Predicted membrane protein/domain Function unknown 75675094 Nonpathogen - hypothetical protein Nwi_0901 1 None None None 75675162 Nonpathogen - hypothetical protein Nwi_0969 1 None None None 75674533 Common radC DNA repair protein RadC Nwi_0335 178 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 75676395 Common - ABC-type branched-chain amino acid transport system permease component Nwi_2210 139 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 75675768 Common - putative glutathione S-transferase YghU Nwi_1576 96 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 75675746 Common - hypothetical protein Nwi_1554 17 COG4725 IME4, Transcriptional activator, adenine-specific DNA methyltransferase Signal transduction mechanisms / Transcription 75676292 Common - integrase Nwi_2106 95 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 75674577 Common - aspartate kinase Nwi_0379 233 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 75675064 Common - transposase IS3/IS911 Nwi_0869 33 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676249 Common - probable ISRm2011-2 transposase protein Nwi_2060 40 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676678 Nonpathogen - hypothetical protein Nwi_2494 3 None None None 75674667 Common gpsA NAD(P)H-dependent glycerol-3-phosphate dehydrogenase Nwi_0469 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 75674996 Common - hypothetical protein Nwi_0800 5 None None None 75676165 Common - Nitric oxide reductase activation protein Nwi_1975 43 COG4548 NorD, Nitric oxide reductase activation protein Inorganic ion transport and metabolism 75677097 Nonpathogen - hypothetical protein Nwi_2916 1 None None None 75674960 Nonpathogen - CoxF protein Nwi_0764 2 None None None 75676867 Common - Universal stress protein, UspA Nwi_2683 74 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 75675246 Common - excinuclease ABC, C subunit Nwi_1053 43 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 75675956 Common - tRNA (uracil-5-)-methyltransferase Gid Nwi_1764 79 COG1206 Gid, NAD(FAD)-utilizing enzyme possibly involved in translation Translation, ribosomal structure and biogenesis 75674967 Common - 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferase of PMT family Nwi_0771 21 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 75675923 Common lipB lipoyltransferase Nwi_1731 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 75676704 Common - branched-chain amino acid aminotransferase Nwi_2520 209 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 75676514 Common - helix-turn-helix, Fis-type Nwi_2329 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675299 Nonpathogen flaF flagellar biosynthesis regulatory protein FlaF Nwi_1106 7 COG5442 FlaF, Flagellar biosynthesis regulator FlaF Cell motility and secretion 75675770 Common - 3-hydroxydecanoyl-(acyl carrier protein) dehydratase Nwi_1578 83 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 75674688 Common - DNA mismatch repair protein Nwi_0490 200 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 75676242 Common - TonB like protein Nwi_2053 51 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 75674784 Common - methionine biosynthesis MetW Nwi_0586 73 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 75675484 Common - ISBm1, transposase orfA Nwi_1292 78 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676918 Common - transketolase Nwi_2734 221 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 75674800 Common - Flagellar hook-length control protein Nwi_0602 12 COG3144 FliK, Flagellar hook-length control protein Cell motility and secretion 75675948 Common - Signal transduction histidine kinase Nwi_1756 219 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 75675715 Common - Secretion protein HlyD Nwi_1523 162 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 75677173 Common - thioesterase superfamily Nwi_2992 136 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 75675827 Nonpathogen - hypothetical protein Nwi_1635 1 None None None 75677226 Common - Fec I like protein Nwi_3045 55 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75675085 Common - beta-lactamase-like Nwi_0890 199 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 75676637 Common - thioredoxin reductase Nwi_2453 246 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 75674656 Common - ABC transporter, ATPase subunit Nwi_0458 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 75676652 Common - thiamine biosynthesis protein ThiC Nwi_2468 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 75674415 Common - tryptophanyl-tRNA synthetase Nwi_0216 231 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 75677267 Common - hypothetical protein Nwi_3089 35 None None None 75675281 Common - ferredoxin Nwi_1088 72 COG0633 Fdx, Ferredoxin Energy production and conversion 75675313 Common flgA flagellar basal body P-ring biosynthesis protein FlgA Nwi_1120 24 COG1261 FlgA, Flagellar basal body P-ring biosynthesis protein Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 75675705 Common - transcription-repair coupling factor Nwi_1513 218 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 75676121 Common - lytic transglycosylase Nwi_1930 149 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 75676240 Common - Fec I like protein Nwi_2051 32 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75674764 Common - hypothetical protein Nwi_0566 86 COG2379 GckA, Putative glycerate kinase Carbohydrate transport and metabolism 75676138 Common - putative phosphoketolase Nwi_1947 65 COG3957 COG3957, Phosphoketolase Carbohydrate transport and metabolism 75676040 Common - beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ Nwi_1849 186 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 75674460 Common - hypothetical protein Nwi_0262 9 COG5340 COG5340, Predicted transcriptional regulator Transcription 75675080 Common - hypothetical protein Nwi_0885 3 None None None 162139840 Common rpmH 50S ribosomal protein L34 Nwi_3076 25 None None None 75675308 Common - Heat shock protein Hsp20 Nwi_1115 151 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 75677046 Common - helix-turn-helix, Fis-type Nwi_2865 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675570 Common rpsH 30S ribosomal protein S8 Nwi_1378 237 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 75677305 Common - NADPH-dependent FMN reductase Nwi_3127 59 COG0431 COG0431, Predicted flavoprotein General function prediction only 75676499 Common - cytochrome c oxidase, subunit I Nwi_2314 164 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 75674398 Common - ribosomal RNA adenine methylase transferase Nwi_0199 42 COG3963 COG3963, Phospholipid N-methyltransferase Lipid metabolism 75676077 Common - NADH dehydrogenase subunit C Nwi_1886 177 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 75675523 Common - hypothetical protein Nwi_1331 14 None None None 75674954 Nonpathogen - hypothetical protein Nwi_0758 1 None None None 75675718 Common - ABC transporter, ATPase subunit Nwi_1526 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 75676167 Nonpathogen - hypothetical protein Nwi_1977 1 None None None 75675646 Nonpathogen - hypothetical protein Nwi_1454 3 None None None 75677073 Common - extracellular solute-binding protein, family 3 Nwi_2892 96 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 75674294 Common - cobyrinic acid a,c-diamide synthase Nwi_0095 228 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 75675891 Common - peptidase S11, D-alanyl-D-alanine carboxypeptidase 1 Nwi_1699 152 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 75677053 Nonpathogen - hypothetical protein Nwi_2872 6 None None None 75674331 Common - Penicillin-binding protein 1A Nwi_0132 204 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 75676735 Common - cytidine/deoxycytidylate deaminase, zinc-binding region Nwi_2551 206 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 75675212 Nonpathogen - hypothetical protein Nwi_1019 1 None None None 75676128 Common - Protein of unknown function DUF83 Nwi_1937 50 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 75677023 Nonpathogen - hypothetical protein Nwi_2840 2 None None None 75676693 Nonpathogen - hypothetical protein Nwi_2509 4 None None None 75675273 Common - CHRD Nwi_1080 18 None None None 75676194 Common - Holliday junction resolvase YqgF Nwi_2004 172 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 75676784 Common - DNA repair photolyase Nwi_2600 106 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 75676891 Nonpathogen - hypothetical protein Nwi_2707 5 None None None 75676887 Common - dihydroorotase Nwi_2703 210 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 75674617 Common - malate dehydrogenase Nwi_0419 189 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 75674369 Nonpathogen - hypothetical protein Nwi_0170 1 None None None 75675158 Common - nitrate reductase, beta subunit Nwi_0965 141 COG1140 NarY, Nitrate reductase beta subunit Energy production and conversion 75674493 Common - TPR repeat protein Nwi_0295 82 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 75674205 Common - transposase, IS4 Nwi_0006 62 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675007 Common - hypothetical protein Nwi_0811 11 None None None 75675506 Common - transposase Nwi_1314 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674547 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding Nwi_0349 46 COG0748 HugZ, Putative heme iron utilization protein Inorganic ion transport and metabolism 75674670 Common - uroporphyrinogen III synthase HEM4 Nwi_0472 34 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 75676188 Common - patatin Nwi_1998 18 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 75677168 Common - cytochrome c, class I Nwi_2987 27 COG3258 COG3258, Cytochrome c Energy production and conversion 75677193 Common - putative serinethreonine protein phosphatase Nwi_3012 15 None None None 75676227 Nonpathogen - hypothetical protein Nwi_2037 1 None None None 75676673 Nonpathogen - hypothetical protein Nwi_2489 3 COG5373 COG5373, Predicted membrane protein Function unknown 75674595 Common - Mg2+ and Co2+ transporter CorB family Nwi_0397 217 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 75675977 Nonpathogen - hypothetical protein Nwi_1785 3 None None None 75676253 Nonpathogen - hypothetical protein Nwi_2064 3 None None None 75677138 Common - lytic murein transglycosylase Nwi_2957 101 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 75675188 Common - alanine dehydrogenase/PNT Nwi_0995 166 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 75677127 Common - response regulator receiver Nwi_2946 220 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 75675267 Common - NAD-dependent epimerase/dehydratase Nwi_1074 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 75675357 Nonpathogen - hypothetical protein Nwi_1164 2 None None None 75677197 Common - hypothetical protein Nwi_3016 205 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 75674365 Common - NAD-dependent epimerase/dehydratase Nwi_0166 79 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 75675779 Common - malic enzyme Nwi_1587 214 COG0281 SfcA, Malic enzyme Energy production and conversion 75674822 Common - Heat shock protein DnaJ Nwi_0624 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 75674391 Common - putative deoxyribonucleotide triphosphate pyrophosphatase Nwi_0192 237 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 75675708 Common - Protein of unknown function DUF502 Nwi_1516 78 COG2928 COG2928, Uncharacterized conserved protein Function unknown 75675461 Common - TonB protein Nwi_1269 20 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 75676372 Common - DSBA oxidoreductase Nwi_2187 47 COG3917 NahD, 2-hydroxychromene-2-carboxylate isomerase Secondary metabolites biosynthesis, transport, and catabolism 75675000 Nonpathogen - hypothetical protein Nwi_0804 2 None None None 75675475 Common - transposase Nwi_1283 76 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675390 Nonpathogen - hypothetical protein Nwi_1197 1 None None None 75674846 Common - HAD-superfamily hydrolase subfamily IA, variant 3 Nwi_0649 161 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 75675997 Common - glycoside hydrolase, family 3 Nwi_1805 169 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 75677201 Common - hypothetical protein Nwi_3020 42 COG3768 COG3768, Predicted membrane protein Function unknown 75676632 Nonpathogen - hypothetical protein Nwi_2448 5 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 75675384 Common - cytochrome c-type biogenesis protein cycH / CcmH Nwi_1191 55 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 75675930 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Nwi_1738 211 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 75676108 Common era GTP-binding protein Era Nwi_1917 234 COG1159 Era, GTPase General function prediction only 75675231 Nonpathogen - hypothetical protein Nwi_1038 1 None None None 75677146 Common - adenylosuccinate synthetase Nwi_2965 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 75675418 Common nadE NAD synthetase Nwi_1225 219 COG0171 NadE, NAD synthase Coenzyme metabolism 75675507 Common - ISRm2011-2 transposase protein Nwi_1315 40 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75677235 Common - bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase Nwi_3055 220 COG4230 COG4230, Delta 1-pyrroline-5-carboxylate dehydrogenase Energy production and conversion 75675269 Common - oxidoreductase Nwi_1076 187 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 75675361 Nonpathogen - hypothetical protein Nwi_1168 3 None None None 75674469 Common - excisionase/Xis, DNA-binding Nwi_0271 25 None None None 75674708 Common - PhoU Nwi_0510 199 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 75676854 Common - ABC transporter, ATPase subunit Nwi_2670 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 75676992 Common - Protein of unknown function DUF1232 Nwi_2808 43 COG3339 COG3339, Uncharacterized conserved protein Function unknown 75677002 Common - integrase, catalytic region Nwi_2818 62 None None None 75677216 Nonpathogen - hypothetical protein Nwi_3035 3 None None None 75675439 Common - acyl carrier protein Nwi_1246 57 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 75676406 Common - Signal transduction histidine kinase Nwi_2221 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 75674283 Common - Outer membrane lipoprotein carrier protein LolA Nwi_0084 43 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 75675866 Nonpathogen - hypothetical protein Nwi_1674 3 None None None 75676530 Common - phosphoserine phosphatase SerB Nwi_2345 148 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 75674946 Common - ribonuclease BN Nwi_0750 93 COG1295 Rbn, Predicted membrane protein Function unknown 75677112 Common - Nitrogen regulatory protein P-II Nwi_2931 11 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 75676030 Common moaC molybdenum cofactor biosynthesis protein C Nwi_1839 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 75675128 Common - MscS Mechanosensitive ion channel Nwi_0935 228 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 75674271 Common - PAS sensor protein Nwi_0072 122 COG2202 AtoS, FOG: PAS/PAC domain Signal transduction mechanisms 75675784 Common - transposase, IS4 Nwi_1592 62 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675362 Nonpathogen - hypothetical protein Nwi_1169 4 None None None 75675887 Common - AAA ATPase Nwi_1695 219 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 75677259 Common - FecR protein Nwi_3080 48 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 75675024 Common - hypothetical protein Nwi_0828 5 None None None 75674894 Nonpathogen - hypothetical protein Nwi_0697 2 None None None 75676086 Nonpathogen - hypothetical protein Nwi_1895 2 None None None 75674653 Common - hypothetical protein Nwi_0455 27 COG3753 COG3753, Uncharacterized protein conserved in bacteria Function unknown 75676949 Common - malate synthase G Nwi_2765 70 COG2225 AceB, Malate synthase Energy production and conversion 75676059 Common - TonB-dependent receptor Nwi_1868 113 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 75675345 Common - major facilitator superfamily MFS_1 Nwi_1152 200 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 75677052 Common - hypothetical protein Nwi_2871 12 None None None 75677042 Common - transposase, IS4 Nwi_2861 62 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676771 Common glyQ glycyl-tRNA synthetase subunit alpha Nwi_2587 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 75676340 Common - MaoC-like dehydratase Nwi_2155 72 COG2030 MaoC, Acyl dehydratase Lipid metabolism 75674209 Common - hypothetical protein Nwi_0010 11 None None None 75677013 Common - hypothetical protein Nwi_2829 5 None None None 75676099 Common - hypothetical protein Nwi_1908 13 None None None 75674930 Common - possible outer membrane protein Nwi_0733 22 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 75675029 Common - cobyrinic acid a,c-diamide synthase Nwi_0833 182 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 75677049 Common - hypothetical protein Nwi_2868 62 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 75674630 Common - OsmC-like protein Nwi_0432 94 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 75674836 Nonpathogen - hypothetical protein Nwi_0638 1 None None None 75676401 Nonpathogen - hypothetical protein Nwi_2216 1 None None None 75674684 Nonpathogen - hypothetical protein Nwi_0486 1 None None None 75676969 Common - isopropylmalate isomerase large subunit Nwi_2785 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 75677038 Nonpathogen - hypothetical protein Nwi_2857 4 None None None 75674921 Common - FecR protein Nwi_0724 47 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 75675881 Nonpathogen - hypothetical protein Nwi_1689 1 None None None 75675347 Nonpathogen - hypothetical protein Nwi_1154 1 None None None 75675336 Common - helix-turn-helix, Fis-type Nwi_1143 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676309 Common - hypothetical protein Nwi_2123 72 COG1475 Spo0J, Predicted transcriptional regulators Transcription 75676039 Common - UDP-N-acetylglucosamine acyltransferase Nwi_1848 148 COG1043 LpxA, Acyl- acyl carrier protein 75674903 Common - invasion associated locus B Nwi_0706 7 COG5342 COG5342, Invasion protein B, involved in pathogenesis General function prediction only 75676767 Common - Transcriptional regulatory protein, TetR family Nwi_2583 13 COG1309 AcrR, Transcriptional regulator Transcription 75676972 Nonpathogen - hypothetical protein Nwi_2788 1 None None None 75674523 Common - hypothetical protein Nwi_0325 30 None None None 75676054 Common - ABC transporter, ATPase subunit Nwi_1863 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 75676695 Common - peptidyl-tRNA hydrolase Nwi_2511 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 75674689 Common - methylase involved in ubiquinone/menaquinone biosynthesis Nwi_0491 65 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 75676902 Common - TolA Nwi_2718 14 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 75674566 Common - hypothetical protein Nwi_0368 183 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 75675878 Common - 3-oxoacyl-(acyl carrier protein) synthase II Nwi_1686 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 75674669 Common hemC porphobilinogen deaminase Nwi_0471 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 75676823 Common - glutathione peroxidase Nwi_2639 114 COG0386 BtuE, Glutathione peroxidase Posttranslational modification, protein turnover, chaperones 75676956 Nonpathogen - hypothetical protein Nwi_2772 3 None None None 75675895 Common - hypothetical protein Nwi_1703 31 COG5458 COG5458, Uncharacterized conserved protein Function unknown 75677237 Common - phage head-tail adaptor, putative Nwi_3058 220 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 75675828 Nonpathogen - hypothetical protein Nwi_1636 1 None None None 75677223 Common - Protein of unknown function DUF900, hydrolase-like Nwi_3042 25 COG4782 COG4782, Uncharacterized protein conserved in bacteria Function unknown 75674994 Nonpathogen - hypothetical protein Nwi_0798 1 None None None 75676741 Common - Protein of unknown function DUF374 Nwi_2557 44 COG2121 COG2121, Uncharacterized protein conserved in bacteria Function unknown 75676962 Common - Protein of unknown function DUF541 Nwi_2778 90 COG2968 COG2968, Uncharacterized conserved protein Function unknown 75675698 Common - CDP-alcohol phosphatidyltransferase Nwi_1506 23 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 75674979 Common - transposase IS3/IS911 Nwi_0783 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675166 Common - transposase, IS4 Nwi_0973 62 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676113 Common - RelA/SpoT protein Nwi_1922 206 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 75675219 Common - putative phosphoketolase Nwi_1026 59 COG3957 COG3957, Phosphoketolase Carbohydrate transport and metabolism 75674608 Common - RNA-binding S4 Nwi_0410 31 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 75677205 Common - glycosyl transferase, family 20 Nwi_3024 97 COG0380 OtsA, Trehalose-6-phosphate synthase Carbohydrate transport and metabolism 75676544 Nonpathogen - Protein of unknown function DUF1328 Nwi_2359 4 COG5487 COG5487, Small integral membrane protein Function unknown 75675149 Nonpathogen - hypothetical protein Nwi_0956 1 None None None 75677183 Common - hypothetical protein Nwi_3002 19 COG1618 COG1618, Predicted nucleotide kinase Nucleotide transport and metabolism 75676410 Common - integrase, catalytic region Nwi_2225 62 None None None 75676578 Common - Short-chain dehydrogenase/reductase SDR Nwi_2393 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 75676873 Common - LytB protein Nwi_2689 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 75675888 Common clpS ATP-dependent Clp protease adaptor protein ClpS Nwi_1696 118 COG2127 COG2127, Uncharacterized conserved protein Function unknown 75676098 Common - Transcriptional regulatory protein, MarR family Nwi_1907 22 COG1846 MarR, Transcriptional regulators Transcription 75676516 Common - Guanosine polyphosphate pyrophosphohydrolase/synthetase Nwi_2331 71 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 75676827 Common - glucose-6-phosphate 1-dehydrogenase Nwi_2643 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 75677244 Common fmt methionyl-tRNA formyltransferase Nwi_3065 215 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 75677180 Nonpathogen - hypothetical protein Nwi_2999 3 COG2900 SlyX, Uncharacterized protein conserved in bacteria Function unknown 75676594 Common - hypothetical protein Nwi_2409 14 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 75676328 Common guaA bifunctional GMP synthase/glutamine amidotransferase protein Nwi_2143 240 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 75675233 Common - hypothetical protein Nwi_1040 50 COG3237 COG3237, Uncharacterized protein conserved in bacteria Function unknown 75675933 Nonpathogen - hypothetical protein Nwi_1741 1 None None None 75674276 Common - hypothetical protein Nwi_0077 4 None None None 75677293 Common - transposase Nwi_3115 76 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674439 Common - hypothetical protein Nwi_0240 9 None None None 75676385 Common - hypothetical protein Nwi_2200 116 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 75675041 Common - possible replication protein A Nwi_0846 33 COG5534 COG5534, Plasmid replication initiator protein DNA replication, recombination, and repair 75676216 Nonpathogen - hypothetical protein Nwi_2026 1 None None None 75674924 Nonpathogen - hypothetical protein Nwi_0727 3 None None None 75675127 Common - Transcriptional regulatory protein, LysR Nwi_0934 92 COG2005 ModE, N-terminal domain of molybdenum-binding protein General function prediction only 75676336 Common - Ppx/GppA phosphatase Nwi_2151 178 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 75674314 Common - hypothetical protein Nwi_0115 207 COG0313 COG0313, Predicted methyltransferases General function prediction only 75675016 Nonpathogen - RecA-family ATPase Nwi_0820 7 COG3598 RepA, RecA-family ATPase DNA replication, recombination, and repair 75675642 Common - GTP-binding protein, HSR1-related Nwi_1450 219 COG2262 HflX, GTPases General function prediction only 75677006 Common - transposase, IS4 Nwi_2822 60 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676939 Common - 3-hydroxybutyrate dehydrogenase Nwi_2755 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 75675185 Common - helix-turn-helix, Fis-type Nwi_0992 223 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 75676463 Common - phosphoenolpyruvate carboxylase Nwi_2278 116 COG2352 Ppc, Phosphoenolpyruvate carboxylase Energy production and conversion 75676269 Common - transposase IS3/IS911 Nwi_2081 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676339 Common - hypothetical protein Nwi_2154 133 COG2081 COG2081, Predicted flavoproteins General function prediction only 75675622 Common - hypothetical protein Nwi_1430 21 None None None 75676944 Common - Thiosulphate-binding protein Nwi_2760 88 COG1613 Sbp, ABC-type sulfate transport system, periplasmic component Inorganic ion transport and metabolism 75674210 Common - peptidase M22, glycoprotease Nwi_0011 201 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 75676455 Common - amine oxidase Nwi_2270 40 COG3349 COG3349, Uncharacterized conserved protein Function unknown 75676556 Common - transposase Nwi_2371 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676181 Nonpathogen - hypothetical protein Nwi_1991 3 None None None 75675843 Common - N-acetyl-gamma-glutamyl-phosphate reductase Nwi_1651 214 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 75676622 Common - lytic murein transglycosylase Nwi_2438 102 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 75674970 Common - nitrate reductase, alpha subunit Nwi_0774 92 COG5013 NarG, Nitrate reductase alpha subunit Energy production and conversion 75676157 Common - RNA polymerase ECF-type sigma factor, possible FecI Nwi_1966 12 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75675403 Common - glycoside hydrolase, family 77 Nwi_1210 118 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 75674329 Common - polyhydroxyalkanoate depolymerase Nwi_0130 44 COG4553 DepA, Poly-beta-hydroxyalkanoate depolymerase Lipid metabolism 75675130 Common - putative pigment protein Nwi_0937 42 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 75675374 Common - gene transfer agent (GTA) orfg15, like protein Nwi_1181 26 None None None 75675869 Common - permease YjgP/YjgQ Nwi_1677 65 COG0795 COG0795, Predicted permeases General function prediction only 75677063 Common - FecR protein Nwi_2882 47 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 75675720 Common - amino acid ABC transporter, inner membrane component Nwi_1528 173 COG4597 BatB, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 75674245 Common - hypothetical protein Nwi_0046 184 COG3178 COG3178, Predicted phosphotransferase related to Ser/Thr protein kinases General function prediction only 75676018 Common - enolase Nwi_1827 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 75676738 Common - hypothetical protein Nwi_2554 22 COG3908 COG3908, Uncharacterized protein conserved in bacteria Function unknown 75674872 Common - cyclic nucleotide-binding protein Nwi_0675 112 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 75675803 Common - glyoxalase/bleomycin resistance protein/dioxygenase Nwi_1611 124 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 75676260 Common - luciferase-like protein Nwi_2071 117 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 75676424 Nonpathogen - hypothetical protein Nwi_2239 5 None None None 75675734 Common - Phage major capsid protein, HK97 Nwi_1542 54 COG4653 COG4653, Predicted phage phi-C31 gp36 major capsid-like protein General function prediction only 75676142 Common - resolvase Nwi_1951 136 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 75675569 Common rpsN 30S ribosomal protein S14 Nwi_1377 185 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 75674752 Common - Small GTP-binding protein Nwi_0554 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 75674776 Common - Protein of unknown function DUF218 Nwi_0578 30 COG1434 COG1434, Uncharacterized conserved protein Function unknown 75676832 Common - multicopper oxidase Nwi_2648 95 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 75676279 Common - conjugation TrbI-like protein Nwi_2091 56 COG2948 VirB10, Type IV secretory pathway, VirB10 components Intracellular trafficking and secretion 75674695 Common rpmF 50S ribosomal protein L32 Nwi_0497 99 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 75674778 Common - ChaC-like protein Nwi_0580 44 COG3703 ChaC, Uncharacterized protein involved in cation transport Inorganic ion transport and metabolism 75675369 Nonpathogen - Phage conserved hypothetical protein Nwi_1176 8 None None None 75677153 Common - major facilitator superfamily MFS_1 Nwi_2972 148 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 75675510 Common - hypothetical protein Nwi_1318 15 COG5388 COG5388, Uncharacterized protein conserved in bacteria Function unknown 75674389 Common - hypothetical protein Nwi_0190 32 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 75676353 Common - hypothetical protein Nwi_2168 12 None None None 75675673 Nonpathogen - hypothetical protein Nwi_1481 4 None None None 75675114 Common - homospermidine synthase Nwi_0921 25 COG5310 COG5310, Homospermidine synthase Secondary metabolites biosynthesis, transport, and catabolism 75676118 Common smpB SsrA-binding protein Nwi_1927 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 75676043 Common - peptidase M50, putative membrane-associated zinc metallopeptidase Nwi_1852 210 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 75675657 Common - peptidase S11, D-alanyl-D-alanine carboxypeptidase 1 Nwi_1465 152 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 75676321 Common - helix-turn-helix, Fis-type Nwi_2135 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675689 Nonpathogen - hypothetical protein Nwi_1497 1 None None None 75675981 Common - glycosyl transferase, family 2 Nwi_1789 117 COG5309 COG5309, Exo-beta-1,3-glucanase Carbohydrate transport and metabolism 75676070 Common - NADH dehydrogenase subunit I Nwi_1879 195 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 75674878 Common - sulfonate/nitrate transport system substrate-binding protein Nwi_0681 27 None None None 75675727 Common - extracellular alpha-helical protein Nwi_1535 81 COG2373 COG2373, Large extracellular alpha-helical protein General function prediction only 75675334 Nonpathogen - hypothetical protein Nwi_1141 1 None None None 75674717 Common - hypothetical protein Nwi_0519 29 COG5385 COG5385, Uncharacterized protein conserved in bacteria Function unknown 75675208 Common - transposase, IS4 Nwi_1015 62 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674486 Common - extracellular solute-binding protein, family 5 Nwi_0288 148 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 75677277 Common - helix-turn-helix, Fis-type Nwi_3099 135 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674355 Common - tRNA and rRNA cytosine-C5-methylase Nwi_0156 209 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 75675812 Nonpathogen - hypothetical protein Nwi_1620 3 None None None 75677083 Common - TonB-dependent receptor Nwi_2902 110 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 75675904 Common - DNA topoisomerase I Nwi_1712 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 75676757 Common groES co-chaperonin GroES Nwi_2573 216 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 75675691 Common - hypothetical protein Nwi_1499 19 COG4731 COG4731, Uncharacterized protein conserved in bacteria Function unknown 75674261 Nonpathogen - hypothetical protein Nwi_0062 9 None None None 75675988 Common queA S-adenosylmethionine:tRNA ribosyltransferase-isomerase Nwi_1796 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 75676997 Common - PepSY-associated TM helix Nwi_2813 28 COG3295 COG3295, Uncharacterized protein conserved in bacteria Function unknown 75676367 Common - monooxygenase, FAD-binding Nwi_2182 78 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 75675118 Nonpathogen - hypothetical protein Nwi_0925 3 None None None 75674624 Common xerC site-specific tyrosine recombinase XerC Nwi_0426 225 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 75674620 Common kgd alpha-ketoglutarate decarboxylase Nwi_0422 147 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 75675441 Common - Protein of unknown function DUF87 Nwi_1248 80 COG0433 COG0433, Predicted ATPase General function prediction only 75674364 Common uppP undecaprenyl pyrophosphate phosphatase Nwi_0165 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 75675590 Common - Chaperone required for the assembly of F1-ATPase Nwi_1398 33 COG5387 COG5387, Chaperone required for the assembly of the mitochondrial F1-ATPase Posttranslational modification, protein turnover, chaperones 75676923 Common - sel1-like repeat Nwi_2739 104 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 75674324 Nonpathogen - hypothetical protein Nwi_0125 7 None None None 75675909 Common - integrase, catalytic region Nwi_1717 62 None None None 75676447 Common - peptidase M20D, amidohydrolase Nwi_2262 168 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 75676719 Common - hypothetical protein Nwi_2535 16 COG4655 COG4655, Predicted membrane protein Function unknown 75676835 Common - multicopper oxidase3 Nwi_2651 128 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 75675739 Nonpathogen - hypothetical protein Nwi_1547 2 COG3747 COG3747, Phage terminase, small subunit DNA replication, recombination, and repair 75674200 Common dnaA chromosomal replication initiation protein Nwi_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 75674956 Common - hypothetical protein Nwi_0760 99 COG1720 COG1720, Uncharacterized conserved protein Function unknown 75675157 Common - TPR repeat and WD-40 repeat protein Nwi_0964 33 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 75674268 Common infC translation initiation factor IF-3 Nwi_0069 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 75674240 Common ubiE ubiquinone/menaquinone biosynthesis methyltransferase Nwi_0041 205 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 75676864 Common - ABC-type nitrate/sulfonate/bicarbonate transport systems periplasmic components Nwi_2680 49 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 75675759 Common - putative outer-membrane protein precursor Nwi_1567 18 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 75675464 Nonpathogen - transcription factor jumonji, jmjC Nwi_1272 6 COG2850 COG2850, Uncharacterized conserved protein Function unknown 75676849 Common - helix-turn-helix, Fis-type Nwi_2665 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675256 Common - fumarylacetoacetate (FAA) hydrolase Nwi_1063 179 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 75674555 Common - DNA polymerase I Nwi_0357 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 75675774 Nonpathogen - hypothetical protein Nwi_1582 3 None None None 75675379 Nonpathogen - hypothetical protein Nwi_1186 1 None None None 75677057 Nonpathogen - hypothetical protein Nwi_2876 1 None None None 75675201 Common - Binding-protein-dependent transport systems inner membrane component Nwi_1008 187 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 75674742 Common - dTDP-glucose 4,6-dehydratase Nwi_0544 231 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 75674804 Common - TrkA-N, Sodium/hydrogen exchanger Nwi_0606 203 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 75675325 Nonpathogen flgB flagellar basal body rod protein FlgB Nwi_1132 10 COG1815 FlgB, Flagellar basal body protein Cell motility and secretion 75677163 Common - hypothetical protein Nwi_2982 122 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 75674527 Common - carbohydrate-selective porin OprB Nwi_0329 26 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 75674704 Common - periplasmic phosphate binding protein Nwi_0506 117 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 75674807 Nonpathogen - hypothetical protein Nwi_0609 1 None None None 75676458 Nonpathogen - hypothetical protein Nwi_2273 3 None None None 75677280 Nonpathogen - hypothetical protein Nwi_3102 2 None None None 75674771 Common - hypothetical protein Nwi_0573 29 None None None 75675752 Nonpathogen - hypothetical protein Nwi_1560 1 None None None 75674673 Nonpathogen - hypothetical protein Nwi_0475 3 None None None 75676898 Common - OmpA/MotB Nwi_2714 150 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 75675106 Common - manganese and iron superoxide dismutase Nwi_0913 205 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 75674911 Nonpathogen - hypothetical protein Nwi_0714 1 COG5567 COG5567, Predicted small periplasmic lipoprotein Cell motility and secretion 75675223 Common - hypothetical protein Nwi_1030 22 COG2187 COG2187, Uncharacterized protein conserved in bacteria Function unknown 75675546 Common - hypothetical protein Nwi_1354 5 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 75674707 Common - phosphate transport system permease protein 1 Nwi_0509 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 75676667 Common - Protein of unknown function DUF497 Nwi_2483 27 COG2929 COG2929, Uncharacterized protein conserved in bacteria Function unknown 75674998 Common - hypothetical protein Nwi_0802 4 None None None 75675808 Common - phage Terminase Nwi_1616 45 COG4626 COG4626, Phage terminase-like protein, large subunit General function prediction only 75677224 Common - TonB-dependent siderophore receptor Nwi_3043 120 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 75676587 Nonpathogen - hypothetical protein Nwi_2402 1 None None None 75674413 Common - transposase Nwi_0214 64 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675083 Common - outer membrane ferric siderophore receptor Nwi_0888 4 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 75675265 Common - NAD-dependent epimerase/dehydratase Nwi_1072 148 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 75674507 Common - ISBm1, transposase orfA Nwi_0309 78 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675713 Common - Acriflavin resistance protein Nwi_1521 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 75674782 Common - hypothetical protein Nwi_0584 33 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 75675921 Common - hypothetical protein Nwi_1729 9 None None None 75675297 Common - hypothetical protein Nwi_1104 48 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 75675913 Common - thiamine-monophosphate kinase Nwi_1721 202 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 75676546 Common - ABC transporter, ATPase subunit Nwi_2361 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 75676635 Common - hypothetical protein Nwi_2451 26 COG2259 COG2259, Predicted membrane protein Function unknown 75675473 Nonpathogen - hypothetical protein Nwi_1281 1 None None None 75674641 Common - gamma-glutamyl kinase Nwi_0443 189 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 75676606 Common - 8-amino-7-oxononanoate synthase Nwi_2421 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 75675999 Common - arginyl-tRNA synthetase, class Ic Nwi_1807 246 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 75677115 Common - Trypsin-like serine protease Nwi_2934 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 75675151 Nonpathogen - hypothetical protein Nwi_0958 1 None None None 75676865 Common - glucan exporter ATP-binding protein Nwi_2681 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 75676006 Common - OmpA/MotB Nwi_1814 161 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 75676111 Common acpS 4'-phosphopantetheinyl transferase Nwi_1920 148 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 75675572 Common rplR 50S ribosomal protein L18 Nwi_1380 215 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 75676646 Nonpathogen - hypothetical protein Nwi_2462 2 COG1379 COG1379, Uncharacterized conserved protein Function unknown 75675048 Common - transposase IS116/IS110/IS902 Nwi_0853 81 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675481 Common - transposase Nwi_1289 76 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675509 Common - glutamate racemase Nwi_1317 189 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 75676434 Nonpathogen - hypothetical protein Nwi_2249 1 None None None 75676225 Common thrS threonyl-tRNA synthetase Nwi_2035 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 75676270 Common - helix-turn-helix, Fis-type Nwi_2082 119 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674286 Common - Transcriptional regulatory protein Nwi_0087 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 75674766 Nonpathogen - hypothetical protein Nwi_0568 4 None None None 75676126 Common - Protein of unknown function DUF196 Nwi_1935 46 COG1343 COG1343, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 75675586 Common - pseudouridine synthase, RluD Nwi_1394 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 75675550 Common - ISBm1, transposase orfA Nwi_1358 78 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676482 Common - FecR protein Nwi_2297 47 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 75676793 Common - hypothetical protein Nwi_2609 17 COG5459 COG5459, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 75675825 Common - phage integrase Nwi_1633 194 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 75676062 Common - glyoxalase/bleomycin resistance protein/dioxygenase Nwi_1871 87 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 75674451 Common - possible ferric siderophore receptor protein Nwi_0253 64 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 75674705 Common - phosphate ABC transporter, permease protein PstC Nwi_0507 222 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 75674818 Nonpathogen - hypothetical protein Nwi_0620 1 None None None 75677214 Common - hypothetical protein Nwi_3033 62 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 75675670 Nonpathogen - Uncharacterized phage protein (possible DNA packaging) Nwi_1478 4 None None None 75676504 Common - propeptide, PepSY amd peptidase M4 Nwi_2319 75 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 75676671 Nonpathogen - hypothetical protein Nwi_2487 1 None None None 75674474 Common - zinc-binding protein Nwi_0276 47 COG3024 COG3024, Uncharacterized protein conserved in bacteria Function unknown 75676911 Nonpathogen - hypothetical protein Nwi_2727 2 None None None 75677171 Common glpD glycerol-3-phosphate dehydrogenase Nwi_2990 147 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 75676174 Nonpathogen - carboxysome shell polypeptide, CsoS3 Nwi_1984 7 None None None 75677268 Common - hypothetical protein Nwi_3090 30 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 75674759 Common - hypothetical protein Nwi_0561 7 None None None 75676676 Nonpathogen - hypothetical protein Nwi_2492 3 None None None 75677114 Common - ParB-like nuclease Nwi_2933 36 COG1475 Spo0J, Predicted transcriptional regulators Transcription 75676150 Nonpathogen - hypothetical protein Nwi_1959 2 None None None 75675801 Common - Cold-shock protein, DNA-binding Nwi_1609 156 COG1278 CspC, Cold shock proteins Transcription 75676654 Common - helix-turn-helix, Fis-type Nwi_2470 38 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 75674635 Common - hypothetical protein Nwi_0437 6 None None None 75675301 Nonpathogen - hypothetical protein Nwi_1108 3 None None None 75676728 Nonpathogen - hypothetical protein Nwi_2544 6 None None None 75676431 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Nwi_2246 125 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 75676541 Common - protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis Nwi_2356 32 COG4321 COG4321, Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis General function prediction only 75675412 Common moaA molybdenum cofactor biosynthesis protein A Nwi_1219 196 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 75676934 Common - Zinc-containing alcohol dehydrogenase superfamily Nwi_2750 193 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 75675286 Nonpathogen - hypothetical protein Nwi_1093 5 None None None 75675494 Common - cyanate hydratase Nwi_1302 41 COG1513 CynS, Cyanate lyase Inorganic ion transport and metabolism 75677021 Common - Phage Gp37Gp68 Nwi_2838 42 COG4422 COG4422, Bacteriophage protein gp37 Function unknown 75676294 Common - transposase for insertion sequence element ISRM11/ISRM2011-2 Nwi_2108 39 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676554 Nonpathogen - hypothetical protein Nwi_2369 2 None None None 75675062 Nonpathogen - hypothetical protein Nwi_0867 1 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 75675632 Common - streptomyces cyclase/dehydrase Nwi_1440 102 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 75676444 Common - phage SPO1 DNA polymerase-related protein Nwi_2259 39 None None None 75676071 Common - NADH dehydrogenase subunit H Nwi_1880 190 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 75674520 Common - Heme exporter protein CcmA Nwi_0322 249 COG4133 CcmA, ABC-type transport system involved in cytochrome c biogenesis, ATPase component Posttranslational modification, protein turnover, chaperones 75676925 Common - hydrophobe/amphiphile efflux-1 HAE1 Nwi_2741 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 75674353 Common - staphylococcus nuclease (SNase-like) Nwi_0154 14 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 75677166 Common - isocitrate lyase Nwi_2985 128 COG2224 AceA, Isocitrate lyase Energy production and conversion 75674404 Common - endonuclease III/Nth Nwi_0205 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 75674855 Common - secretin/TonB Nwi_0658 102 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 75677099 Common - integrase, catalytic region Nwi_2918 62 None None None 75675092 Common - hypothetical protein Nwi_0897 39 COG3919 COG3919, Predicted ATP-grasp enzyme General function prediction only 75674665 Common - acetate--CoA ligase Nwi_0467 212 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 75675291 Common - FAD dependent oxidoreductase Nwi_1098 82 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 75674462 Common - hypothetical protein Nwi_0264 20 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 75675557 Common rplD 50S ribosomal protein L4 Nwi_1365 217 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 75674375 Nonpathogen - hypothetical protein Nwi_0176 1 None None None 75677106 Common - transposase Nwi_2925 76 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675875 Common gmk guanylate kinase Nwi_1683 214 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 75676497 Common - hypothetical protein Nwi_2312 13 COG1981 COG1981, Predicted membrane protein Function unknown 75676563 Common - S-adenosylmethionine synthetase Nwi_2378 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 75675611 Common - major facilitator superfamily MFS_1 Nwi_1419 86 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 75674948 Common - cobalamin adenosyltransferase Nwi_0752 129 COG2096 COG2096, Uncharacterized conserved protein Function unknown 75674849 Nonpathogen - hypothetical protein Nwi_0652 1 None None None 75675355 Nonpathogen - hypothetical protein Nwi_1162 2 None None None 75676852 Common - hypothetical protein Nwi_2668 50 COG5621 COG5621, Predicted secreted hydrolase General function prediction only 75674231 Common - enoyl-(acyl carrier protein) reductase Nwi_0032 221 COG0623 FabI, Enoyl- acyl-carrier-protein 75676286 Common - conjugal transfer protein trbE Nwi_2098 52 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 75675500 Common - phosphoribosylformylglycinamidine synthase II Nwi_1308 233 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 75675954 Common - hypothetical protein Nwi_1762 18 None None None 75675160 Nonpathogen - hypothetical protein Nwi_0967 1 None None None 75674588 Common - preprotein translocase subunit SecA Nwi_0390 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 75674791 Nonpathogen - hypothetical protein Nwi_0593 5 None None None 75674549 Common - beta-lactamase Nwi_0351 66 COG2367 PenP, Beta-lactamase class A Defense mechanisms 75675190 Common - NAD/NADP transhydrogenase beta subunit Nwi_0997 123 COG1282 PntB, NAD/NADP transhydrogenase beta subunit Energy production and conversion 75675589 Common - ISBm1, transposase orfA Nwi_1397 80 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676421 Common - methylmalonyl-CoA mutase Nwi_2236 108 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 75674802 Common - UbiE/COQ5 methyltransferase Nwi_0604 199 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 75676994 Common - 4Fe-4S ferredoxin, iron-sulfur binding Nwi_2810 160 COG1146 COG1146, Ferredoxin Energy production and conversion 75674725 Common - hypothetical protein Nwi_0527 16 None None None 75674345 Nonpathogen - hypothetical protein Nwi_0146 3 None None None 75674820 Common - pyridoxamine 5'-phosphate oxidase Nwi_0622 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 75674561 Common - ISRm2011-2 transposase protein Nwi_0363 40 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676251 Common - RNA methyltransferase TrmH, group 3 Nwi_2062 213 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 75675173 Common - Transcriptional regulatory protein, LysR family Nwi_0980 184 COG0583 LysR, Transcriptional regulator Transcription 75676725 Common - riboflavin kinase / FAD synthetase Nwi_2541 211 COG0196 RibF, FAD synthase Coenzyme metabolism 75677136 Nonpathogen - hypothetical protein Nwi_2955 1 None None None 75675979 Common - putative beta (1-6) glucans synthase Nwi_1787 15 COG5309 COG5309, Exo-beta-1,3-glucanase Carbohydrate transport and metabolism 75677143 Common - hypothetical protein Nwi_2962 32 None None None 75674844 Common - Antifreeze-like protein Nwi_0647 78 COG2089 SpsE, Sialic acid synthase Cell envelope biogenesis, outer membrane 75676601 Common - Histidine triad (HIT) protein Nwi_2416 229 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 75674884 Common - hypothetical protein Nwi_0687 5 None None None 75675053 Common - TENA/THI-4 protein Nwi_0858 74 COG0819 TenA, Putative transcription activator Transcription 75674281 Common - aminotransferase, class I and II Nwi_0082 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 75676060 Nonpathogen - hypothetical protein Nwi_1869 3 None None None 75675433 Common - hypothetical protein Nwi_1240 235 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 75675792 Common - hypothetical protein Nwi_1600 49 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 75676149 Common - hypothetical protein Nwi_1958 8 None None None 75675844 Common - DedA Nwi_1652 143 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 75674703 Common - Signal transduction histidine kinase Nwi_0505 220 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 75677110 Common rbcL ribulose bisophosphate carboxylase Nwi_2929 67 COG1850 RbcL, Ribulose 1,5-bisphosphate carboxylase, large subunit Carbohydrate transport and metabolism 75675199 Common - spermidine/putrescine ABC transporter ATP-binding subunit Nwi_1006 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 75676232 Common - Secretion protein HlyD Nwi_2042 161 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 75675183 Common - Protein of unknown function DUF882 Nwi_0990 60 COG3108 COG3108, Uncharacterized protein conserved in bacteria Function unknown 75675864 Nonpathogen - hypothetical protein Nwi_1672 1 None None None 75676258 Common - hypothetical protein Nwi_2069 40 COG3002 COG3002, Uncharacterized protein conserved in bacteria Function unknown 75674428 Common - threonine synthase Nwi_0229 165 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 75675941 Common - peptidase M48, Ste24p Nwi_1749 102 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 75677055 Common - hypothetical protein Nwi_2874 11 None None None 75676022 Common - 2-dehydro-3-deoxyphosphooctonate aldolase Nwi_1831 186 COG2877 KdsA, 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase Cell envelope biogenesis, outer membrane 75675616 Common - hypothetical protein Nwi_1424 96 COG1720 COG1720, Uncharacterized conserved protein Function unknown 75675288 Common - transposase, IS4 Nwi_1095 66 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675819 Nonpathogen - hypothetical protein Nwi_1627 2 None None None 75675026 Common - transcriptional regulator, XRE family Nwi_0830 15 COG1396 HipB, Predicted transcriptional regulators Transcription 75676197 Common pyrB aspartate carbamoyltransferase catalytic subunit Nwi_2007 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 75675214 Nonpathogen - hypothetical protein Nwi_1021 2 None None None 75676786 Common - Protein of unknown function Zinc binding 2 Nwi_2602 86 COG2321 COG2321, Predicted metalloprotease General function prediction only 75675169 Common - probable ISRm2011-2 transposase protein Nwi_0976 45 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674495 Common - type II secretion system protein Nwi_0297 79 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 75677071 Common - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Nwi_2890 138 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 75676124 Common - putative porin Nwi_1933 13 None None None 75677031 Common - integrase, catalytic region Nwi_2850 51 None None None 75676511 Common - Protein of unknown function DUF1008 Nwi_2326 18 COG3721 HugX, Putative heme iron utilization protein Inorganic ion transport and metabolism 75676893 Common - pyruvate phosphate dikinase Nwi_2709 233 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 75674694 Common mtgA monofunctional biosynthetic peptidoglycan transglycosylase Nwi_0496 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 75676737 Common xseA exodeoxyribonuclease VII large subunit Nwi_2553 204 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 75676344 Common - methylmalonate-semialdehyde dehydrogenase Nwi_2159 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 75675607 Common - lipopolysaccharide biosynthesis Nwi_1415 79 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 75675386 Common - Cytochrome c-type biogenesis protein CcmF Nwi_1193 142 COG1138 CcmF, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 75676478 Common - hypothetical protein Nwi_2293 20 COG3553 COG3553, Uncharacterized protein conserved in bacteria Function unknown 75674207 Common - UspA Nwi_0008 26 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 75676169 Nonpathogen - hypothetical protein Nwi_1979 6 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 75676789 Common - A/G-specific adenine glycosylase MutY Nwi_2605 213 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 75675067 Common - helix-turn-helix, Fis-type Nwi_0872 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676496 Common - hypothetical protein Nwi_2311 14 COG3336 COG3336, Predicted membrane protein Function unknown 75676483 Common - xylose isomerase-like TIM barrel Nwi_2298 22 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 75676744 Common - peptidase U62, modulator of DNA gyrase Nwi_2560 159 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 75674860 Nonpathogen - hypothetical protein Nwi_0663 1 None None None 75674611 Common - hypothetical protein Nwi_0413 120 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 75675451 Common - virulence-associated protein E Nwi_1259 41 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 75675579 Common - 30S ribosomal protein S11 Nwi_1387 248 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 75674551 Common ligD ATP-dependent DNA ligase Nwi_0353 95 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 75675539 Common rplA 50S ribosomal protein L1 Nwi_1347 235 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 75677298 Common - hypothetical protein Nwi_3120 17 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 75676687 Common - Protein of unknown function DUF185 Nwi_2503 92 COG1565 COG1565, Uncharacterized conserved protein Function unknown 75675076 Common - Transcriptional regulatory protein GntR family Nwi_0881 188 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 75675970 Common - twin-arginine translocation protein TatB Nwi_1778 104 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 75674941 Common - Trypsin-like serine protease Nwi_0744 180 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 162139850 Common argD bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein Nwi_0513 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 75674292 Common holA DNA polymerase III subunit delta Nwi_0093 54 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 75675772 Nonpathogen - hypothetical protein Nwi_1580 1 None None None 75674447 Common - hypothetical protein Nwi_0248 31 COG5328 COG5328, Uncharacterized protein conserved in bacteria Function unknown 75675859 Common anmK anhydro-N-acetylmuramic acid kinase Nwi_1667 120 COG2377 COG2377, Predicted molecular chaperone distantly related to HSP70-fold metalloproteases Posttranslational modification, protein turnover, chaperones 75674986 Nonpathogen - hypothetical protein Nwi_0790 1 None None None 75676537 Common - Protein of unknown function DUF1321 Nwi_2352 40 COG3814 COG3814, Uncharacterized protein conserved in bacteria Function unknown 75674597 Nonpathogen - hypothetical protein Nwi_0399 9 COG5330 COG5330, Uncharacterized protein conserved in bacteria Function unknown 75677028 Common - probable ISRm2011-2 transposase protein Nwi_2847 40 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676592 Common - helix-turn-helix, Fis-type Nwi_2407 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675492 Common - hypothetical protein Nwi_1300 26 COG2110 COG2110, Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 General function prediction only 75676230 Common - MotA/TolQ/ExbB proton channel Nwi_2040 128 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 75674726 Nonpathogen - hypothetical protein Nwi_0528 3 None None None 75674767 Nonpathogen - hypothetical protein Nwi_0569 1 None None None 75675193 Common - aquaporin Z Nwi_1000 123 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 75675112 Nonpathogen - hypothetical protein Nwi_0919 1 None None None 75674589 Common - hypothetical protein Nwi_0391 56 COG3034 COG3034, Uncharacterized protein conserved in bacteria Function unknown 75676361 Common - serine O-acetyltransferase Nwi_2176 190 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 75676297 Common - amylo-alpha-1,6-glucosidase Nwi_2111 52 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 75676847 Common - isochorismatase hydrolase Nwi_2663 92 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 75675626 Common - type I secretion outer membrane protein, TolC Nwi_1434 146 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 75676814 Nonpathogen - hypothetical protein Nwi_2630 3 None None None 75674357 Common purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Nwi_0158 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 75675692 Common - cupin region Nwi_1500 67 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 75676750 Common hisG ATP phosphoribosyltransferase Nwi_2566 174 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 75676656 Nonpathogen - collagen triple helix repeat protein Nwi_2472 1 None None None 75676420 Common - 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK Nwi_2235 198 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 75674869 Nonpathogen - hypothetical protein Nwi_0672 1 None None None 75675951 Common - hypothetical protein Nwi_1759 20 COG4254 COG4254, Uncharacterized protein conserved in bacteria Function unknown 75674311 Common - Protein of unknown function DUF1052 Nwi_0112 30 COG5321 COG5321, Uncharacterized protein conserved in bacteria Function unknown 75674958 Common - cytochrome c oxidase, subunit I Nwi_0762 163 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 75674554 Common - Lysine exporter protein (LYSE/YGGA) Nwi_0356 109 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 75674905 Common - transposase Nwi_0708 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674985 Common - hypothetical protein Nwi_0789 8 None None None 75677158 Common - shikimate/quinate 5-dehydrogenase Nwi_2977 224 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 75676477 Nonpathogen - hypothetical protein Nwi_2292 3 None None None 75677269 Common - hypothetical protein Nwi_3091 10 COG4430 COG4430, Uncharacterized protein conserved in bacteria Function unknown 75675958 Common - squalene/phytoene synthase Nwi_1766 47 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 75676627 Common - N-formylglutamate amidohydrolase Nwi_2443 46 COG3931 COG3931, Predicted N-formylglutamate amidohydrolase Amino acid transport and metabolism 75675137 Common - hypothetical protein Nwi_0944 2 None None None 75675423 Common - GCN5-related N-acetyltransferase Nwi_1230 47 COG0456 RimI, Acetyltransferases General function prediction only 75675549 Nonpathogen - hypothetical protein Nwi_1357 1 None None None 75674481 Common metH B12-dependent methionine synthase Nwi_0283 175 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 75676942 Common - Sulfate ABC transporter, permease protein CysW Nwi_2758 167 COG4208 CysW, ABC-type sulfate transport system, permease component Inorganic ion transport and metabolism 75677282 Nonpathogen - hypothetical protein Nwi_3104 3 None None None 75675782 Common - Hemolysins and related proteins Nwi_1590 218 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 75674744 Common - dTDP-4-dehydrorhamnose 3,5-epimerase related Nwi_0546 168 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 75676136 Common - helix-turn-helix, Fis-type Nwi_1945 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674649 Common - dinucleoside polyphosphate hydrolase Nwi_0451 113 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 75677086 Common - high-affinity nickel-transporter Nwi_2905 39 COG2215 COG2215, ABC-type uncharacterized transport system, permease component General function prediction only 75674675 Common - short-chain dehydrogenase/reductase SDR Nwi_0477 222 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 75674594 Common - 3-dehydroquinate synthase Nwi_0396 205 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 75676214 Common panB 3-methyl-2-oxobutanoate hydroxymethyltransferase Nwi_2024 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 75677310 Common - Protein of unknown function DUF411 Nwi_3132 64 COG3019 COG3019, Predicted metal-binding protein General function prediction only 75675595 Common - SmpA/OmlA Nwi_1403 26 COG2913 SmpA, Small protein A (tmRNA-binding) Translation, ribosomal structure and biogenesis 75674445 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase Nwi_0246 219 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 75674243 Common - deoxyUTP pyrophosphatase subfamily 1 Nwi_0044 182 COG0756 Dut, dUTPase Nucleotide transport and metabolism 75675754 Nonpathogen - hypothetical protein Nwi_1562 1 None None None 75675150 Common - Transcriptional regulatory protein, LuxR family Nwi_0957 156 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 75675224 Common - hypothetical protein Nwi_1031 98 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 75676378 Nonpathogen - hypothetical protein Nwi_2193 1 None None None 75675687 Nonpathogen - hypothetical protein Nwi_1495 1 None None None 75674327 Common - GCN5-related N-acetyltransferase Nwi_0128 36 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 75677202 Common - hypothetical protein Nwi_3021 50 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 75675027 Common - Phage integrase Nwi_0831 187 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 75675592 Common - type III secretion proteins, related to flagellar biosynthesis protein FlhB Nwi_1400 120 COG2257 COG2257, Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB Function unknown 75674834 Common - enoyl-CoA hydratase/isomerase Nwi_0636 152 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 75674702 Common - hypothetical protein Nwi_0504 49 COG0392 COG0392, Predicted integral membrane protein Function unknown 75676817 Common - NUDIX hydrolase Nwi_2633 29 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 75677260 Common - hypothetical protein Nwi_3082 19 COG1041 COG1041, Predicted DNA modification methylase DNA replication, recombination, and repair 75675972 Common - Protein-L-isoaspartate(D-aspartate) O-methyltransferase Nwi_1780 153 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 75676759 Nonpathogen - hypothetical protein Nwi_2575 3 None None None 75676427 Common - drug resistance transporter Bcr/CflA subfamily Nwi_2242 157 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 75677302 Common - Low molecular weight phosphotyrosine protein phosphatase Nwi_3124 115 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 75675726 Common - Penicillin-binding protein 1C Nwi_1534 200 COG4953 PbpC, Membrane carboxypeptidase/penicillin-binding protein PbpC Cell envelope biogenesis, outer membrane 75676355 Common - transglutaminase-like cysteine peptidase, BTLCP Nwi_2170 23 COG3672 COG3672, Predicted periplasmic protein Function unknown 75677126 Common - resolvase Nwi_2945 131 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 75676460 Common - possible RND superfamily transporter Nwi_2275 71 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 75674576 Common - Phosphoenolpyruvate-protein phosphotransferase Nwi_0378 233 COG3605 PtsP, Signal transduction protein containing GAF and PtsI domains Signal transduction mechanisms 75674719 Common - CheW-like protein Nwi_0521 125 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 75674939 Common - hypothetical protein Nwi_0742 42 COG2346 COG2346, Truncated hemoglobins General function prediction only 75675737 Common - phage Terminase Nwi_1545 46 COG4626 COG4626, Phage terminase-like protein, large subunit General function prediction only 75676323 Common - RNA polymerase sigma factor SigJ Nwi_2138 51 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75675367 Common - Phage major tail protein, TP901-1 Nwi_1174 19 COG5437 COG5437, Predicted secreted protein Function unknown 75676029 Common - indole-3-glycerol phosphate synthase Nwi_1838 219 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 75676469 Common - Secretion protein HlyD Nwi_2284 172 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 75675178 Nonpathogen - hypothetical protein Nwi_0985 3 None None None 75677215 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding Nwi_3034 47 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 75675395 Nonpathogen - hypothetical protein Nwi_1202 2 None None None 75676970 Nonpathogen - hypothetical protein Nwi_2786 2 None None None 75675659 Nonpathogen - hypothetical protein Nwi_1467 4 None None None 75675102 Common - conserved hypothetical protein, putative DNA helicase Nwi_0909 74 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 75676147 Nonpathogen - hypothetical protein Nwi_1956 2 COG2405 COG2405, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 75675303 Common - chemotactic signal-response protein CheL Nwi_1110 10 COG3951 COG3951, Rod binding protein Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 75674626 Common - rare lipoprotein A Nwi_0428 136 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 75676981 Common - malonyl-CoA synthase Nwi_2797 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 75676202 Common - cyclopropane-fatty-acyl-phospholipid synthase Nwi_2012 132 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 75675732 Common - hypothetical protein Nwi_1540 11 None None None 75676012 Common - NADPH-dependent FMN reductase Nwi_1820 110 COG0431 COG0431, Predicted flavoprotein General function prediction only 75676209 Common - short-chain dehydrogenase/reductase SDR Nwi_2019 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 75674244 Common - Histidine kinase Nwi_0045 221 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 75674346 Common - possible transposase Nwi_0147 30 None None None 75675516 Common - patatin Nwi_1324 121 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 75675332 Nonpathogen - hypothetical protein Nwi_1139 4 None None None 75676371 Nonpathogen - hypothetical protein Nwi_2186 1 None None None 75675447 Common - DEAD/DEAH box helicase Nwi_1255 124 COG4096 HsdR, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 75675512 Common - Rhomboid-like protein Nwi_1320 17 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 75676368 Nonpathogen - hypothetical protein Nwi_2183 3 None None None 75676880 Common - Sua5/YciO/YrdC/YwlC Nwi_2696 236 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 75674972 Common - nitrate reductase, beta subunit Nwi_0776 141 COG1140 NarY, Nitrate reductase beta subunit Energy production and conversion 75676636 Common - Transcriptional regulatory proteins, AsnC/Lrp family Nwi_2452 152 COG1522 Lrp, Transcriptional regulators Transcription 75675485 Common - integrase, catalytic region Nwi_1293 57 None None None 75675986 Common - cysteine synthase Nwi_1794 219 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 75675326 Common flgC flagellar basal body rod protein FlgC Nwi_1133 125 COG1558 FlgC, Flagellar basal body rod protein Cell motility and secretion 75675430 Common - OmpA/MotB Nwi_1237 108 COG1360 MotB, Flagellar motor protein Cell motility and secretion 75675055 Common - conjugation TrbI-like protein Nwi_0860 57 COG2948 VirB10, Type IV secretory pathway, VirB10 components Intracellular trafficking and secretion 75677289 Common - transcriptional regulator, XRE family Nwi_3111 34 COG5499 COG5499, Predicted transcription regulator containing HTH domain Transcription 75676776 Common - polyprenyl synthetase Nwi_2592 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 75675876 Common - hypothetical protein Nwi_1684 137 COG1561 COG1561, Uncharacterized stress-induced protein Function unknown 75675217 Common - Universal stress protein, UspA Nwi_1024 39 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 162139848 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase Nwi_1304 162 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 75676154 Common - hypothetical protein Nwi_1963 10 None None None 75676572 Common - NAD-dependent epimerase/dehydratase Nwi_2387 190 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 75675240 Common - UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase Nwi_1047 207 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 75677279 Common - hypothetical protein Nwi_3101 7 None None None 75676416 Common - hypothetical protein Nwi_2231 85 COG0433 COG0433, Predicted ATPase General function prediction only 75675121 Common hemH ferrochelatase Nwi_0928 150 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 75676161 Nonpathogen - hypothetical protein Nwi_1971 1 None None None 75675071 Common - choloylglycine hydrolase Nwi_0876 52 COG3049 COG3049, Penicillin V acylase and related amidases Cell envelope biogenesis, outer membrane 75676909 Common ruvA Holliday junction DNA helicase motor protein Nwi_2725 210 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 75677271 Common - helix-turn-helix protein, CopG Nwi_3093 19 COG3609 COG3609, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain Transcription 75674658 Common - carboxymuconolactone decarboxylase Nwi_0460 67 COG2128 COG2128, Uncharacterized conserved protein Function unknown 75674637 Common rplU 50S ribosomal protein L21 Nwi_0439 203 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 75674780 Common - cyclohexadienyl dehydrogenase Nwi_0582 171 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 75676779 Common - FAD dependent oxidoreductase Nwi_2595 108 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 75675235 Common - N-acetylmuramoyl-L-alanine amidase, family 2 Nwi_1042 111 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 75676591 Common - NAD-dependent epimerase/dehydratase Nwi_2406 235 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 75676092 Common - multicopper oxidase Nwi_1901 50 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 75676115 Common - Protein of unknown function DUF88 Nwi_1924 63 COG1432 COG1432, Uncharacterized conserved protein Function unknown 75674406 Common - methyltransferase FkbM Nwi_0207 59 COG4798 COG4798, Predicted methyltransferase General function prediction only 75676522 Nonpathogen - hypothetical protein Nwi_2337 5 None None None 75676562 Common - S-adenosyl-L-homocysteine hydrolase Nwi_2377 178 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 75674928 Common - hypothetical protein Nwi_0731 16 COG5606 COG5606, Uncharacterized conserved small protein Function unknown 75676381 Common - Protein of unknown function DUF72 Nwi_2196 82 COG1801 COG1801, Uncharacterized conserved protein Function unknown 75676989 Common - hypothetical protein Nwi_2805 6 None None None 75676343 Common - acyl-CoA dehydrogenase Nwi_2158 164 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 75677108 Common - CbbX like protein Nwi_2927 52 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 75674321 Common - imidazole glycerol phosphate synthase subunit HisF Nwi_0122 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 75674212 Common - ferric-uptake regulator Nwi_0013 191 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 75675531 Common - FecR protein Nwi_1339 47 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 75675018 Nonpathogen - hypothetical protein Nwi_0822 1 None None None 75675444 Common - restriction endonuclease Nwi_1252 33 COG3440 COG3440, Predicted restriction endonuclease Defense mechanisms 75675932 Common - adenylyl cyclase class-3/4/guanylyl cyclase Nwi_1740 84 COG4252 COG4252, Predicted transmembrane sensor domain Signal transduction mechanisms 75676712 Common - Protein of unknown function DUF519 Nwi_2528 85 COG2961 ComJ, Protein involved in catabolism of external DNA General function prediction only 75676338 Common - ABC transporter, ATPase subunit Nwi_2153 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 75675002 Common - hypothetical protein Nwi_0806 10 COG5471 COG5471, Uncharacterized conserved protein Function unknown 75675237 Common - hypothetical protein Nwi_1044 25 COG5462 COG5462, Predicted secreted (periplasmic) protein Function unknown 75675634 Common - 4-diphosphocytidyl-2C-methyl-D-erythritol synthase Nwi_1442 196 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 75677012 Nonpathogen - hypothetical protein Nwi_2828 2 None None None 75674443 Common - possible outer membrane protein Nwi_0244 19 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 75675315 Common flgF flagellar basal body rod protein FlgF Nwi_1122 119 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 75676087 Common - UbiE/COQ5 methyltransferase Nwi_1896 164 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 75675452 Nonpathogen - hypothetical protein Nwi_1260 1 None None None 75676975 Common leuD isopropylmalate isomerase small subunit Nwi_2791 212 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 75674750 Common - glycosyl transferase, group 1 Nwi_0552 102 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 75674456 Common - hypothetical protein Nwi_0258 6 None None None 75676262 Common - Periplasmic binding protein Nwi_2073 60 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 75675396 Common - histone-like DNA-binding protein Nwi_1203 99 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 75675791 Common - Cold-shock protein, DNA-binding Nwi_1599 176 COG1278 CspC, Cold shock proteins Transcription 75674519 Common - Cytochrome c-type biogenesis protein CcmB Nwi_0321 80 COG2386 CcmB, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 75676709 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Nwi_2525 203 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 75676074 Common - NADH dehydrogenase subunit E Nwi_1883 154 COG1905 NuoE, NADH:ubiquinone oxidoreductase 24 kD subunit Energy production and conversion 75674839 Nonpathogen - hypothetical protein Nwi_0641 2 None None None 75675037 Common - ISBm1, transposase orfA Nwi_0842 78 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676900 Common - diguanylate cyclase/phophodiesterase Nwi_2716 178 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 75675032 Common - hypothetical protein Nwi_0837 8 COG4453 COG4453, Uncharacterized protein conserved in bacteria Function unknown 75676004 Nonpathogen - hypothetical protein Nwi_1812 1 None None None 75675675 Common - peptidase U35, phage prohead HK97 Nwi_1483 38 COG3740 COG3740, Phage head maturation protease General function prediction only 75675858 Common - hypothetical protein Nwi_1666 84 COG2945 COG2945, Predicted hydrolase of the alpha/beta superfamily General function prediction only 75676037 Common - glycosyl transferase, family 19 Nwi_1846 139 COG0763 LpxB, Lipid A disaccharide synthetase Cell envelope biogenesis, outer membrane 75676598 Common - aminotransferase, class V Nwi_2413 157 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 75676947 Common - sulfate adenylyltransferase subunit 2 Nwi_2763 137 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 75676211 Nonpathogen - hypothetical protein Nwi_2021 3 None None None 75677150 Common - phosphoserine aminotransferase Nwi_2969 65 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 75676310 Nonpathogen - hypothetical protein Nwi_2124 3 None None None 75674949 Common - electron transfer flavoprotein beta-subunit Nwi_0753 153 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 75674263 Common - Protein of unknown function DUF71, ATP-binding region Nwi_0064 47 COG2102 COG2102, Predicted ATPases of PP-loop superfamily General function prediction only 75674686 Common - transcriptional regulatory protein, LysR family Nwi_0488 171 COG0583 LysR, Transcriptional regulator Transcription 75676961 Nonpathogen - transcription activator, effector binding Nwi_2777 7 COG4978 COG4978, Transcriptional regulator, effector-binding domain/component Transcription / Signal transduction mechanisms 75674693 Common - polyprenyl synthetase Nwi_0495 241 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 75676954 Nonpathogen - hypothetical protein Nwi_2770 1 None None None 75676435 Nonpathogen - hypothetical protein Nwi_2250 9 COG5330 COG5330, Uncharacterized protein conserved in bacteria Function unknown 75676876 Common - fructose-1,6-bisphosphate aldolase Nwi_2692 175 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 75675902 Common - polysaccharide deacetylase Nwi_1710 92 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 75674734 Common - type I secretion membrane fusion protein, HlyD Nwi_0536 119 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 75677033 Common - glycosyl transferase, family 28 Nwi_2852 37 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 75674540 Common - hypothetical protein Nwi_0342 16 None None None 75674962 Common - cytochrome c oxidase, subunit III Nwi_0766 157 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 75676182 Common - NADH/Ubiquinone/plastoquinone (complex I) Nwi_1992 203 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 75677090 Nonpathogen - hypothetical protein Nwi_2909 2 None None None 75674969 Common - cytochrome c, class I Nwi_0773 10 COG3474 COG3474, Cytochrome c2 Energy production and conversion 75674531 Common - Binding-protein-dependent transport systems inner membrane component Nwi_0333 92 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 75674882 Common - aliphatic sulfonate ABC transporter ATP-binding protein Nwi_0685 49 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 75674501 Nonpathogen - peptidase A24A, prepilin type IV Nwi_0303 7 COG4960 CpaA, Flp pilus assembly protein, protease CpaA Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 75674488 Common - Binding-protein-dependent transport systems inner membrane component Nwi_0290 219 COG4174 COG4174, ABC-type uncharacterized transport system, permease component General function prediction only 75675474 Common - transposase, IS4 Nwi_1282 62 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674222 Common - hypothetical protein Nwi_0023 39 COG2740 COG2740, Predicted nucleic-acid-binding protein implicated in transcription termination Transcription 75675990 Common - peptidyl-prolyl cis-trans isomerase, cyclophilin type Nwi_1798 194 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 75674237 Common - UBA/THIF-type NAD/FAD binding fold Nwi_0038 223 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 75676791 Common - Protein-disulfide isomerase Nwi_2607 95 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 75675870 Common - permease YjgP/YjgQ Nwi_1678 98 COG0795 COG0795, Predicted permeases General function prediction only 75675807 Common - hypothetical protein Nwi_1615 31 COG5281 COG5281, Phage-related minor tail protein Function unknown 75675565 Common rpsQ 30S ribosomal protein S17 Nwi_1373 219 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 75675761 Nonpathogen - hypothetical protein Nwi_1569 4 None None None 75676494 Common - glycoside hydrolase 15-related Nwi_2309 71 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 75675284 Common - hypothetical protein Nwi_1091 57 COG0392 COG0392, Predicted integral membrane protein Function unknown 75675934 Common - hypothetical protein Nwi_1742 11 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 75676749 Common hisZ ATP phosphoribosyltransferase regulatory subunit Nwi_2565 186 COG3705 HisZ, ATP phosphoribosyltransferase involved in histidine biosynthesis Amino acid transport and metabolism 75676808 Common - NUDIX hydrolase Nwi_2624 124 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 75675203 Common - coenzyme A transferase Nwi_1010 94 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 75674943 Common - DNA-3-methyladenine glycosidase II Nwi_0747 100 COG0122 AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 75675536 Common secE preprotein translocase subunit SecE Nwi_1344 24 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 75674543 Common - PTS system fructose subfamily IIA component Nwi_0345 94 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 75676927 Common - hypothetical protein Nwi_2743 28 None None None 75675104 Common - Heavy metal translocating P-type ATPase Nwi_0911 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 162139853 Common hisE phosphoribosyl-ATP pyrophosphatase Nwi_0121 100 COG0140 HisI, Phosphoribosyl-ATP pyrophosphohydrolase Amino acid transport and metabolism 75674203 Common gyrB DNA gyrase subunit B Nwi_0004 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 75675964 Common - Peptidase M23B Nwi_1772 191 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 75677241 Common - Protein of unknown function DUF6, transmembrane Nwi_3062 53 COG2962 RarD, Predicted permeases General function prediction only 75677309 Common - heavy metal efflux pump CzcA Nwi_3131 177 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 75677058 Common - hypothetical protein Nwi_2877 19 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 75677300 Common - hypothetical protein Nwi_3122 11 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 75674613 Common - ABC transporter, ATPase subunit Nwi_0415 249 COG4181 COG4181, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 75676247 Nonpathogen - hypothetical protein Nwi_2058 1 None None None 75676446 Common - phage SPO1 DNA polymerase-related protein Nwi_2261 151 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 75675167 Common mobA molybdopterin-guanine dinucleotide biosynthesis protein A Nwi_0974 72 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 75676727 Common - peptidase A8, signal peptidase II Nwi_2543 30 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 75676912 Common - divalent cation transporter Nwi_2728 170 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 75677321 Common rpsT 30S ribosomal protein S20 Nwi_3143 150 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 75677159 Common - elongation factor G Nwi_2978 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 75676798 Common - glutamine amidotransferase of anthranilate synthase Nwi_2614 230 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 75674853 Common - sigma-70 region 2 Nwi_0656 114 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75675502 Common - hypothetical protein Nwi_1310 65 COG4301 COG4301, Uncharacterized conserved protein Function unknown 75676788 Common - glutathione S-transferase Nwi_2604 99 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 75675992 Nonpathogen - hypothetical protein Nwi_1800 3 None None None 75675065 Common - helix-turn-helix, Fis-type Nwi_0870 135 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674863 Common - ABC-type branched-chain amino acid transport system permease component Nwi_0666 123 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 75676288 Common - transposase IS3/IS911 Nwi_2100 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674232 Common - 3-oxoacyl-(acyl carrier protein) synthase I Nwi_0033 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 75674616 Common - AFG1-like ATPase Nwi_0418 103 COG1485 COG1485, Predicted ATPase General function prediction only 75674341 Nonpathogen - hypothetical protein Nwi_0142 1 None None None 75677190 Common - transcriptional regulator, PadR-like Nwi_3009 56 COG1695 COG1695, Predicted transcriptional regulators Transcription 75675453 Nonpathogen - hypothetical protein Nwi_1261 1 None None None 75675293 Common - Protein of unknown function DUF1078 Nwi_1100 120 COG1256 FlgK, Flagellar hook-associated protein Cell motility and secretion 75674599 Common - Heat shock protein DnaJ Nwi_0401 49 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 75674976 Common - C4-dicarboxylate transporter/malic acid transport protein Nwi_0780 39 COG1275 TehA, Tellurite resistance protein and related permeases Inorganic ion transport and metabolism 75675353 Common - Protein of unknown function DUF264 Nwi_1160 26 COG5323 COG5323, Uncharacterized conserved protein Function unknown 75675432 Common - rhodanese-like protein Nwi_1239 67 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 75675263 Common - ADP-L-glycero-D-manno-heptose-6-epimerase Nwi_1070 220 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 75675682 Common - lipoprotein, putative Nwi_1490 10 None None None 75674438 Common - FoF1 ATP synthase, subunit I Nwi_0239 30 COG5336 COG5336, Uncharacterized protein conserved in bacteria Function unknown 75676809 Common - Protein of unknown function DUF1285 Nwi_2625 44 COG3816 COG3816, Uncharacterized protein conserved in bacteria Function unknown 75674299 Common rho transcription termination factor Rho Nwi_0100 206 COG1158 Rho, Transcription termination factor Transcription 75675175 Common - two component diguanylate phophodiesterase Nwi_0982 158 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 75674219 Common trmB tRNA (guanine-N(7))-methyltransferase Nwi_0020 167 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 75674793 Common - helix-turn-helix, Fis-type Nwi_0595 171 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 75674308 Common - Smr protein/MutS2 Nwi_0109 53 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 75675351 Common - transposase Nwi_1158 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676366 Common - hypothetical protein Nwi_2181 15 COG4391 COG4391, Uncharacterized protein conserved in bacteria Function unknown 75676134 Common - resolvase Nwi_1943 143 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 75674841 Common - Short-chain dehydrogenase/reductase Nwi_0643 160 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 75675831 Nonpathogen - hypothetical protein Nwi_1639 2 None None None 75675253 Common - putative lipoprotein Nwi_1060 126 COG4105 ComL, DNA uptake lipoprotein General function prediction only 75676952 Nonpathogen - hypothetical protein Nwi_2768 2 None None None 75676376 Common groES co-chaperonin GroES Nwi_2191 216 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 75676861 Nonpathogen - hypothetical protein Nwi_2677 3 None None None 75677134 Common - glutamine amidotransferase, class-II Nwi_2953 202 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 75674826 Common - phosphoglycerate/bisphosphoglycerate mutase Nwi_0628 171 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 75675073 Common - hypothetical protein Nwi_0878 63 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 75677231 Common - TonB-dependent receptor Nwi_3051 71 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 75675470 Common - ISSpo3, transposase Nwi_1278 32 None None None 75674690 Common - alpha/beta hydrolase fold Nwi_0492 92 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 75674251 Common - folylpolyglutamate synthetase Nwi_0052 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 75676198 Common - dihydroorotase Nwi_2008 207 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 75675503 Common - Protein of unknown function DUF323 Nwi_1311 88 COG1262 COG1262, Uncharacterized conserved protein Function unknown 75676068 Common - NADH dehydrogenase subunit K Nwi_1877 132 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 75675184 Common - hypothetical protein Nwi_0991 79 COG2989 COG2989, Uncharacterized protein conserved in bacteria Function unknown 75676402 Nonpathogen - hypothetical protein Nwi_2217 1 None None None 75674208 Common - nitrogen-fixing NifU Nwi_0009 98 COG0694 COG0694, Thioredoxin-like proteins and domains Posttranslational modification, protein turnover, chaperones 75676156 Common - transposase IS3/IS911 Nwi_1965 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674558 Common - hypothetical protein Nwi_0360 53 COG3577 COG3577, Predicted aspartyl protease General function prediction only 75676890 Common - metal dependent phosphohydrolase Nwi_2706 31 COG1896 COG1896, Predicted hydrolases of HD superfamily General function prediction only 75676858 Common - helix-turn-helix, Fis-type Nwi_2674 119 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676392 Common - alpha/beta hydrolase Nwi_2207 166 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 75676341 Common - 3-hydroxyisobutyrate dehydrogenase Nwi_2156 188 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 75677209 Common - OmpA/MotB Nwi_3028 129 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 75674870 Common - Binding-protein-dependent transport systems inner membrane component Nwi_0673 187 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 75674720 Common - CheY protein Nwi_0522 222 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 75676122 Common - transposase IS3/IS911 Nwi_1931 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676732 Common mutL DNA mismatch repair protein Nwi_2548 191 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 75677124 Common - hypothetical protein Nwi_2943 9 None None None 75676256 Common - putative L-sorbosone dehydrogenase (SNDH) Nwi_2067 62 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 75676780 Common - phage SPO1 DNA polymerase-related protein Nwi_2596 155 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 75676409 Common - ISBm1, transposase orfA Nwi_2224 78 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674394 Common - GrpE protein Nwi_0195 224 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 75674382 Common - sel1-like repeat protein Nwi_0183 115 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 75676506 Common - amidinotransferase Nwi_2321 22 COG1834 COG1834, N-Dimethylarginine dimethylaminohydrolase Amino acid transport and metabolism 75675279 Common - hypothetical protein Nwi_1086 146 COG1283 NptA, Na+/phosphate symporter Inorganic ion transport and metabolism 75675060 Common - helix-turn-helix, Fis-type Nwi_0865 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675388 Common - peptidase S1C, Do Nwi_1195 223 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 75675042 Common - DNA methylase N-4/N-6 Nwi_0847 75 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 75674333 Common hslO Hsp33-like chaperonin Nwi_0134 127 COG1281 COG1281, Disulfide bond chaperones of the HSP33 family Posttranslational modification, protein turnover, chaperones 75676535 Common - dihydrofolate reductase region Nwi_2350 146 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 75675756 Common - phage Gp37Gp68 Nwi_1564 41 COG4422 COG4422, Bacteriophage protein gp37 Function unknown 75676384 Common - molybdopterin binding protein Nwi_2199 129 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 75676765 Common - FAD linked oxidase Nwi_2581 201 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 75675406 Common - 6-phosphogluconate dehydrogenase, NAD-binding Nwi_1213 190 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 75674530 Common - ABC transporter, ATPase subunit Nwi_0332 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 75674454 Nonpathogen - hypothetical protein Nwi_0256 1 None None None 75674479 Common - glycerol kinase Nwi_0281 178 COG0554 GlpK, Glycerol kinase Energy production and conversion 75676140 Common - Heavy metal translocating P-type ATPase Nwi_1949 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 75674918 Common - glutathione S-transferase Nwi_0721 69 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 75676176 Common - ribulose bisphosphate carboxylase, small chain Nwi_1986 29 COG4451 RbcS, Ribulose bisphosphate carboxylase small subunit Energy production and conversion 75677139 Common - UTP--glucose-1-phosphate uridylyltransferase Nwi_2958 228 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 75674808 Common - hypothetical protein Nwi_0610 22 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 75675857 Common - Cysteine sulfinate desulfinase/cysteine desulfurase Nwi_1665 235 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 75674606 Nonpathogen - hypothetical protein Nwi_0408 1 None None None 75676485 Common - acyl-CoA synthetase Nwi_2300 181 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 75675270 Common - DegT/DnrJ/EryC1/StrS aminotransferase Nwi_1077 192 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 75674256 Common - hypothetical protein Nwi_0057 16 None None None 75674373 Common - ABC transporter, ATPase subunit Nwi_0174 249 COG1137 YhbG, ABC-type (unclassified) transport system, ATPase component General function prediction only 75675414 Common - ribose-5-phosphate isomerase A Nwi_1221 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 75674518 Common - Cytochrome c-type biogenesis protein CcmC Nwi_0320 126 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 75675711 Nonpathogen - hypothetical protein Nwi_1519 1 None None None 75675863 Common - peptidase M23B Nwi_1671 190 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 75675618 Common - glycerophosphoryl diester phosphodiesterase Nwi_1426 80 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 75677141 Common - methionine sulfoxide reductase B Nwi_2960 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 75674402 Common - methylated-DNA-(protein)-cysteine S-methyltransferase Nwi_0203 209 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 75676295 Common - filamentation induced by cAMP protein Fic Nwi_2109 110 COG3177 COG3177, Uncharacterized conserved protein Function unknown 75676560 Common - Cold-shock protein, DNA-binding Nwi_2375 175 COG1278 CspC, Cold shock proteins Transcription 75674664 Common - peptidase S24 Nwi_0466 35 COG2932 COG2932, Predicted transcriptional regulator Transcription 75674363 Common - glutathione S-transferase Nwi_0164 39 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 75675694 Common - allophanate hydrolase subunit 2 Nwi_1502 115 COG1984 DUR1, Allophanate hydrolase subunit 2 Amino acid transport and metabolism 75676543 Common - helix-turn-helix, Fis-type Nwi_2358 119 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675851 Common - HesB/YadR/YfhF Nwi_1659 163 COG0316 IscA, Uncharacterized conserved protein Function unknown 75675559 Common rplB 50S ribosomal protein L2 Nwi_1367 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 75675552 Common - 30S ribosomal protein S7 Nwi_1360 248 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 75676277 Common - AAA ATPase Nwi_2089 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 75675953 Common - acetyltransferase Nwi_1761 46 COG2388 COG2388, Predicted acetyltransferase General function prediction only 75676569 Common - NAD-dependent epimerase/dehydratase Nwi_2384 200 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 75677177 Common - Methyl-accepting chemotaxis protein Nwi_2996 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 75674768 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Nwi_0570 237 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 75674798 Common - Protein of unknown function DUF1153 Nwi_0600 27 None None None 75674932 Common - hypothetical protein Nwi_0735 20 None None None 75675742 Nonpathogen - hypothetical protein Nwi_1550 2 None None None 75674963 Common - Protein of unknown function DUF983 Nwi_0767 29 COG5349 COG5349, Uncharacterized protein conserved in bacteria Function unknown 75675944 Common - acetyl-CoA biotin carboxyl carrier Nwi_1752 192 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 75676824 Nonpathogen - hypothetical protein Nwi_2640 4 None None None 75677026 Common - outer membrane autotransporter barrel Nwi_2845 26 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 75675081 Common - hypothetical protein Nwi_0886 3 None None None 75675317 Common fliM flagellar motor switch protein FliM Nwi_1124 111 COG1868 FliM, Flagellar motor switch protein Cell motility and secretion 75676740 Common - three-deoxy-D-manno-octulosonic-acid transferase Nwi_2556 126 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 75676031 Common - Molybdopterin biosynthesis enzyme, MoeA Nwi_1840 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 75674852 Common - transposase Nwi_0655 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676220 Common - transposase Nwi_2030 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676171 Common - Carboxysome structural polypeptide Nwi_1981 46 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 75677250 Common - acetylglutamate kinase Nwi_3071 219 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 75675621 Common - DNA polymerase IV Nwi_1429 185 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 75676052 Nonpathogen - hypothetical protein Nwi_1861 1 None None None 75675748 Common - hypothetical protein Nwi_1556 8 None None None 75675907 Common - peptide chain release factor 2 Nwi_1715 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 75676441 Common - hypothetical protein Nwi_2256 91 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 75674284 Common - exodeoxyribonuclease III xth Nwi_0085 194 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 75676046 Common - di-trans-poly-cis-decaprenylcistransferase Nwi_1855 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 75674419 Nonpathogen - hypothetical protein Nwi_0220 1 None None None 75675098 Nonpathogen - hypothetical protein Nwi_0905 2 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 75675747 Nonpathogen - hypothetical protein Nwi_1555 2 None None None 75677068 Common - ribonucleotide-diphosphate reductase subunit beta Nwi_2887 154 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 75674652 Common - hypothetical protein Nwi_0454 48 COG2261 COG2261, Predicted membrane protein Function unknown 75675296 Common flbT flagellar biosynthesis repressor FlbT Nwi_1103 17 COG5443 FlbT, Flagellar biosynthesis regulator FlbT Cell motility and secretion 75674506 Common - integrase, catalytic region Nwi_0308 62 None None None 75677221 Common - adenylyl cyclase class-3/4/guanylyl cyclase Nwi_3040 120 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 75676648 Common - FAD dependent oxidoreductase Nwi_2464 85 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 75676859 Common - glutathione S-transferase Nwi_2675 79 COG0435 ECM4, Predicted glutathione S-transferase Posttranslational modification, protein turnover, chaperones 75674472 Common - hypothetical protein Nwi_0274 6 None None None 75677312 Common - Heavy metal translocating P-type ATPase Nwi_3134 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 75676102 Common - arginyl-tRNA-protein transferase Nwi_1911 85 COG2935 COG2935, Putative arginyl-tRNA:protein arginylyltransferase Posttranslational modification, protein turnover, chaperones 75676020 Nonpathogen - hypothetical protein Nwi_1829 1 None None None 75675823 Nonpathogen - hypothetical protein Nwi_1631 1 None None None 75676886 Common - hypothetical protein Nwi_2702 12 None None None 75676660 Nonpathogen - putative bacterioferritin Nwi_2476 6 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 75675181 Common - Protein of unknown function DUF1244 Nwi_0988 38 COG3492 COG3492, Uncharacterized protein conserved in bacteria Function unknown 75675814 Nonpathogen - Uncharacterized phage protein (possible DNA packaging) Nwi_1622 4 None None None 75675730 Common - hypothetical protein Nwi_1538 2 None None None 75676117 Nonpathogen - hypothetical protein Nwi_1926 2 None None None 75675602 Common - saccharopine dehydrogenase Nwi_1410 46 COG3268 COG3268, Uncharacterized conserved protein Function unknown 75676014 Common - hypothetical protein Nwi_1822 15 None None None 75676977 Common - aspartate-semialdehyde dehydrogenase Nwi_2793 236 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 75675946 Common - Bacteriophytochrome (light-regulated signal transduction histidine kinase) Nwi_1754 220 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 75674648 Common - hypothetical protein Nwi_0450 54 COG2861 COG2861, Uncharacterized protein conserved in bacteria Function unknown 75675724 Common - glycosyl transferase, family 2 Nwi_1532 176 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 75674325 Common - imidazoleglycerol-phosphate dehydratase Nwi_0126 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 75676264 Common - ABC-type Fe3+-siderophore transport system permease component Nwi_2075 192 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 75675143 Nonpathogen - aspartate/glutamate/uridylate kinase Nwi_0950 16 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 75676357 Common - Carbonic anhydrase/acetyltransferase isoleucine patch superfamily Nwi_2172 206 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 75677147 Nonpathogen - hypothetical protein Nwi_2966 1 None None None 75675974 Nonpathogen - hypothetical protein Nwi_1782 1 None None None 75676697 Common - hypothetical protein Nwi_2513 34 COG5465 COG5465, Uncharacterized conserved protein Function unknown 75674772 Common - response regulator receiver Nwi_0574 219 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 75675397 Common - glycogen/starch/alpha-glucan phosphorylase Nwi_1204 139 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 75675370 Common - gene transfer agent (GTA) like protein Nwi_1177 22 COG5281 COG5281, Phage-related minor tail protein Function unknown 75674951 Common - 3-hydroxybutyryl-CoA dehydrogenase Nwi_0755 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 75674424 Common - protoheme IX farnesyltransferase Nwi_0225 169 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 75674700 Common - OmpA/MotB Nwi_0502 156 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 75676173 Common - Ethanolamine utilization protein EutN/carboxysome structural protein Ccml Nwi_1983 12 COG4576 CcmL, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 75675030 Common - recombinase Nwi_0834 47 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 75676281 Common - Conjugal transfer protein Nwi_2093 34 COG3701 TrbF, Type IV secretory pathway, TrbF components Intracellular trafficking and secretion 75676746 Common ubiA prenyltransferase Nwi_2562 168 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 75676987 Common - argininosuccinate synthase Nwi_2803 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 75675498 Common - phosphoribosylformylglycinamidine synthase I Nwi_1306 231 COG0047 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain Nucleotide transport and metabolism 75674348 Common - glycosyl transferase, family 2 Nwi_0149 51 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 75674691 Common - ferric-uptake regulator Nwi_0493 117 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 75675171 Common - TrpR binding protein WrbA Nwi_0978 116 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 75675123 Common - Protein of unknown function DUF107 Nwi_0930 38 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 75674246 Nonpathogen - hypothetical protein Nwi_0047 3 None None None 75675846 Common - glyoxalase/bleomycin resistance protein/dioxygenase Nwi_1654 41 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 75676019 Common - 7-cyano-7-deazaguanine reductase Nwi_1828 129 COG0780 COG0780, Enzyme related to GTP cyclohydrolase I General function prediction only 75675721 Common - extracellular solute-binding protein, family 3 Nwi_1529 120 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 75675685 Common - TOPRIM Nwi_1493 23 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 75675735 Common - peptidase S14, ClpP Nwi_1543 60 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 75674628 Common - F0F1 ATP synthase subunit alpha Nwi_0430 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 75674249 Common - UvrD/REP helicase Nwi_0050 203 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 75674265 Common pheS phenylalanyl-tRNA synthetase subunit alpha Nwi_0066 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 75675514 Common - transposase Nwi_1322 75 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676373 Common - xanthine-guanine phosphoribosyltransferase Nwi_2188 83 COG2236 COG2236, Predicted phosphoribosyltransferases General function prediction only 75676812 Common - double-transmembrane region Nwi_2628 31 None None None 75677003 Common - helix-turn-helix, Fis-type Nwi_2819 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675242 Common murD UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase Nwi_1049 211 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 75675518 Common - hypothetical protein Nwi_1326 179 COG0759 COG0759, Uncharacterized conserved protein Function unknown 75674761 Nonpathogen - hypothetical protein Nwi_0563 3 None None None 75676081 Nonpathogen - hypothetical protein Nwi_1890 1 None None None 75675984 Nonpathogen - hypothetical protein Nwi_1792 4 None None None 75677262 Common - PilT protein Nwi_3084 15 COG5611 COG5611, Predicted nucleic-acid-binding protein, contains PIN domain General function prediction only 75675574 Common rpmD 50S ribosomal protein L30 Nwi_1382 88 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 75676203 Common - replicative DNA helicase Nwi_2013 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 75675328 Common fliQ flagellar biosynthesis protein FliQ Nwi_1135 18 COG1987 FliQ, Flagellar biosynthesis pathway, component FliQ Cell motility and secretion / Intracellular trafficking and secretion 75674713 Common - hypothetical protein Nwi_0515 109 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 75674974 Common - nitrate reductase gamma subunit Nwi_0778 62 COG2181 NarI, Nitrate reductase gamma subunit Energy production and conversion 75674876 Common - hypothetical protein Nwi_0679 32 COG3536 COG3536, Uncharacterized protein conserved in bacteria Function unknown 75676363 Common - alpha/beta hydrolase fold Nwi_2178 144 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 75674253 Common trpA tryptophan synthase subunit alpha Nwi_0054 212 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 75676349 Common - glutathione-dependent formaldehyde-activating, GFA Nwi_2164 52 COG3791 COG3791, Uncharacterized conserved protein Function unknown 75674441 Common - 5-aminolevulinate synthase Nwi_0242 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 75676574 Nonpathogen - hypothetical protein Nwi_2389 2 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 75675796 Common - Carbamoyl-phosphate synthetase large chain Nwi_1604 235 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 75675664 Common - phage Terminase Nwi_1472 45 COG4626 COG4626, Phage terminase-like protein, large subunit General function prediction only 75675542 Common rpoB DNA-directed RNA polymerase subunit beta Nwi_1350 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 75677295 Common - hypothetical protein Nwi_3117 11 None None None 75676658 Common - transposase Nwi_2474 76 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75677140 Nonpathogen - hypothetical protein Nwi_2959 4 None None None 75675524 Common - hypothetical protein Nwi_1332 15 COG5330 COG5330, Uncharacterized protein conserved in bacteria Function unknown 75676026 Common - triosephosphate isomerase Nwi_1835 230 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 75674396 Common dnaK molecular chaperone DnaK Nwi_0197 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 75675624 Common pleD response regulator PleD Nwi_1432 224 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 75674461 Nonpathogen - hypothetical protein Nwi_0263 2 None None None 75675490 Common - transposase IS3/IS911 Nwi_1298 30 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676774 Common - methyltransferase small Nwi_2590 35 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 75674668 Common - O-sialoglycoprotein endopeptidase Nwi_0470 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 75676625 Common dnaG DNA primase Nwi_2441 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 75675778 Nonpathogen - hypothetical protein Nwi_1586 3 None None None 75676683 Common - transposase Nwi_2499 76 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675483 Common - ISRm2011-2 transposase protein Nwi_1291 45 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676620 Common - Protein of unknown function DUF81 Nwi_2436 21 COG0730 COG0730, Predicted permeases General function prediction only 75675905 Common - 3'-5' exoribonuclease, VacB and RNase II/Ribonuclease R Nwi_1713 192 COG0557 VacB, Exoribonuclease R Transcription 75676845 Common - multicopper oxidase Nwi_2661 56 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 75675063 Common - hypothetical protein Nwi_0868 9 None None None 75676752 Common - YdjC-like protein Nwi_2568 48 COG3394 COG3394, Uncharacterized protein conserved in bacteria Function unknown 75675100 Common - hypothetical protein Nwi_0907 56 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 75677035 Common - hypothetical protein Nwi_2854 18 COG5340 COG5340, Predicted transcriptional regulator Transcription 75675468 Nonpathogen - hypothetical protein Nwi_1276 2 None None None 75674360 Common - gamma-glutamyltranspeptidase Nwi_0161 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 75677196 Common - putative serine/threonine protein phosphatase Nwi_3015 39 None None None 75675139 Common - alpha amylase Nwi_0946 95 COG3280 TreY, Maltooligosyl trehalose synthase Carbohydrate transport and metabolism 75675547 Common - hypothetical protein Nwi_1355 15 COG5653 COG5653, Protein involved in cellulose biosynthesis (CelD) Cell envelope biogenesis, outer membrane 75675135 Nonpathogen - hypothetical protein Nwi_0942 5 None None None 75676815 Common - TonB-dependent receptor Nwi_2631 97 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 75677156 Common - Ferrous iron transport protein B Nwi_2975 176 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 75675425 Common - Conserved hypothetical protein 730 Nwi_1232 108 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 75675533 Nonpathogen - hypothetical protein Nwi_1341 1 None None None 75676839 Common - putative monovalent cation/H+ antiporter subunit C Nwi_2655 97 COG1006 MnhC, Multisubunit Na+/H+ antiporter, MnhC subunit Inorganic ion transport and metabolism 75676229 Common - Biopolymer transport protein ExbD/TolR Nwi_2039 136 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 75674746 Common - glycosyl transferase, family 2 Nwi_0548 71 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 75675226 Nonpathogen - hypothetical protein Nwi_1033 1 None None None 75674592 Nonpathogen - hypothetical protein Nwi_0394 5 None None None 75675780 Common aspS aspartyl-tRNA synthetase Nwi_1588 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 75677318 Nonpathogen - hypothetical protein Nwi_3140 3 None None None 75677088 Common - Transcriptional regulatory protein, ArsR family Nwi_2907 68 COG0640 ArsR, Predicted transcriptional regulators Transcription 75675421 Common cysS cysteinyl-tRNA synthetase Nwi_1228 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 75676675 Common - GCN5-related N-acetyltransferase Nwi_2491 85 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 75674677 Common - hypothetical protein Nwi_0479 18 COG1872 COG1872, Uncharacterized conserved protein Function unknown 75675394 Common - Cation efflux protein Nwi_1201 195 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 75676315 Common - hypothetical protein Nwi_2129 31 None None None 75676419 Common - dihydroneopterin aldolase Nwi_2234 89 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 75675631 Common - lipoyl synthase Nwi_1439 190 COG0320 LipA, Lipoate synthase Coenzyme metabolism 75674330 Common - Protein of unknown function DUF45 Nwi_0131 150 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 75675251 Common - cell division protein FtsZ Nwi_1058 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 75675960 Common secF preprotein translocase subunit SecF Nwi_1768 205 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 75675020 Nonpathogen - hypothetical protein Nwi_0824 2 COG2452 COG2452, Predicted site-specific integrase-resolvase DNA replication, recombination, and repair 75675446 Common - N-6 DNA methylase Nwi_1254 161 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 75674483 Common - prephenate dehydratase Nwi_0285 213 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 75674756 Nonpathogen - hypothetical protein Nwi_0558 1 None None None 75675152 Common - hypothetical protein Nwi_0959 6 None None None 75674925 Nonpathogen - hypothetical protein Nwi_0728 6 None None None 75675899 Nonpathogen - hypothetical protein Nwi_1707 6 None None None 75675124 Common - Sugar isomerase, KpsF/GutQ family protein Nwi_0931 158 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 75676641 Nonpathogen - hypothetical protein Nwi_2457 1 None None None 75676966 Common - tRNA (guanine-N1-)-methyltransferase Nwi_2782 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 75675342 Common - Protein of unknown function DUF1214 Nwi_1149 32 COG5402 COG5402, Uncharacterized conserved protein Function unknown 75676844 Common - hypothetical protein Nwi_2660 5 None None None 75675703 Common - AMP-dependent synthetase and ligase Nwi_1511 54 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 75676596 Common - probable ISRm2011-2 transposase protein Nwi_2411 45 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676035 Common gltX glutamyl-tRNA synthetase Nwi_1844 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 75676552 Common - Ribosomal L11 methyltransferase Nwi_2367 173 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 75676442 Common - hypothetical protein Nwi_2257 25 COG4544 COG4544, Uncharacterized conserved protein Function unknown 75674351 Common - ErfK/YbiS/YcfS/YnhG Nwi_0152 91 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 75676879 Common - Transcriptional regulatory protein, LysR family Nwi_2695 177 COG0583 LysR, Transcriptional regulator Transcription 75676940 Common - hypothetical protein Nwi_2756 55 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 75677212 Common - Acriflavin resistance protein Nwi_3031 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 75677304 Common - Arsenite efflux pump ACR3 Nwi_3126 128 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 75674832 Common - exodeoxyribonuclease VII small subunit Nwi_0634 32 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 75676312 Common - hypothetical protein Nwi_2126 9 None None None 75677188 Common - transposase Nwi_3007 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676079 Common - NADH dehydrogenase subunit A Nwi_1888 162 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 75674898 Common - putative hydroxylase Nwi_0701 44 COG3128 PiuC, Uncharacterized iron-regulated protein Function unknown 75675035 Common - Protein of unknown function DUF736 Nwi_0840 26 COG5489 COG5489, Uncharacterized conserved protein Function unknown 75674275 Common - Nitrogen regulatory protein P-II Nwi_0076 187 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 75676963 Common - Signal recognition particle protein Nwi_2779 246 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 75674811 Common - beta-lactamase-like Nwi_0613 158 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 75674542 Common - phosphoryl transfer system, HPr Nwi_0344 125 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 75675528 Nonpathogen - hypothetical protein Nwi_1336 3 None None None 75677047 Common - helix-turn-helix, Fis-type Nwi_2866 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674359 Common - major facilitator superfamily MFS_1 Nwi_0160 73 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 75674513 Common - pseudouridine synthase Nwi_0315 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 75675663 Common - hypothetical protein Nwi_1471 33 COG5281 COG5281, Phage-related minor tail protein Function unknown 75675519 Nonpathogen - hypothetical protein Nwi_1327 9 COG3904 COG3904, Predicted periplasmic protein Function unknown 75676688 Common - prolipoprotein diacylglyceryl transferase Nwi_2504 207 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 75674318 Common - Signal transduction histidine kinase Nwi_0119 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 75674477 Common - thiolase Nwi_0279 167 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 75674470 Common - phage integrase Nwi_0272 44 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 75676878 Common - fructose-1,6-bisphosphatase Nwi_2694 108 COG0158 Fbp, Fructose-1,6-bisphosphatase Carbohydrate transport and metabolism 75677243 Common - formylmethionine deformylase Nwi_3064 214 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 75677018 Common - hypothetical protein Nwi_2835 24 None None None 75674736 Common - lipopolysaccharide biosynthesis protein Nwi_0538 26 COG3754 RgpF, Lipopolysaccharide biosynthesis protein Cell envelope biogenesis, outer membrane 75677239 Common - acetyl-CoA acetyltransferase Nwi_3060 168 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 75676184 Nonpathogen - hypothetical protein Nwi_1994 1 None None None 75676451 Common ispH 4-hydroxy-3-methylbut-2-enyl diphosphate reductase Nwi_2266 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 75676152 Common - hypothetical protein Nwi_1961 8 None None None 75675676 Nonpathogen - hypothetical protein Nwi_1484 2 None None None 75674880 Common - Binding-protein-dependent transport systems inner membrane component Nwi_0683 191 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 75677248 Common dapD 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase Nwi_3069 138 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 75674567 Common - DNA polymerase III subunits gamma and tau Nwi_0369 246 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 75676438 Common - hypothetical protein Nwi_2253 74 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 75676058 Common - protein of unknown function DUF461 Nwi_1867 82 COG2847 COG2847, Uncharacterized protein conserved in bacteria Function unknown 75674239 Common - formamidopyrimidine-DNA glycolase Nwi_0040 179 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 75676716 Nonpathogen - hypothetical protein Nwi_2532 5 None None None 75676163 Common - hypothetical protein Nwi_1973 10 None None None 75676324 Common - antibiotic biosynthesis monooxygenase Nwi_2139 12 None None None 75674837 Common - transposase IS3/IS911 Nwi_0639 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676907 Common - 4-hydroxybenzoyl-CoA thioesterase Nwi_2723 117 COG0824 FcbC, Predicted thioesterase General function prediction only 75677010 Common - hypothetical protein Nwi_2826 5 None None None 75675798 Common - ETC complex I subunit conserved region Nwi_1606 37 None None None 75675305 Nonpathogen fliX flagellar assembly regulator FliX Nwi_1112 5 None None None 75674225 Common truB tRNA pseudouridine synthase B Nwi_0026 245 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 75674983 Nonpathogen - hypothetical protein Nwi_0787 1 None None None 75675077 Common - hypothetical protein Nwi_0882 89 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 75676608 Common - hypothetical protein Nwi_2423 67 COG4111 COG4111, Uncharacterized conserved protein General function prediction only 75676388 Common - AAA ATPase Nwi_2203 95 COG0714 COG0714, MoxR-like ATPases General function prediction only 75676548 Nonpathogen - hypothetical protein Nwi_2363 2 None None None 75676414 Common - hypothetical protein Nwi_2229 117 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 75675228 Common - Universal stress protein, UspA Nwi_1035 36 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 75676580 Common - Hexapeptide transferase family protein Nwi_2395 72 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 75675966 Common - response regulator receiver Nwi_1774 54 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 75676396 Common - ABC transporter, ATPase subunit Nwi_2211 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 75675057 Common - Phage Gp37Gp68 Nwi_0862 34 COG4422 COG4422, Bacteriophage protein gp37 Function unknown 75675538 Common rplK 50S ribosomal protein L11 Nwi_1346 246 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 75674304 Common - DNA polymerase III, epsilon subunit Nwi_0105 193 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 75675046 Common - ISRm2011-2 transposase protein Nwi_0851 40 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675647 Common - Outer membrane efflux protein Nwi_1455 56 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 75676669 Common - putative ABC transporter ATP-binding protein Nwi_2485 247 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 75675295 Common - pyridoxal-dependent decarboxylase Nwi_1102 106 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 75674214 Common - PhoH-like protein Nwi_0015 199 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 75674315 Common - hypothetical protein Nwi_0116 147 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 75675890 Nonpathogen - hypothetical protein Nwi_1698 14 COG5490 COG5490, Uncharacterized conserved protein Function unknown 75676520 Common - hypothetical protein Nwi_2335 18 None None None 75675070 Common - surface antigen (D15) Nwi_0875 98 COG0729 COG0729, Outer membrane protein Cell envelope biogenesis, outer membrane 75676095 Common - glutamine synthetase type I Nwi_1904 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 75674306 Common - hypothetical protein Nwi_0107 49 COG4395 COG4395, Uncharacterized protein conserved in bacteria Function unknown 75676094 Common - Nitrogen regulatory protein P-II Nwi_1903 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 75674434 Common - H+-transporting two-sector ATPase, B/B' subunit Nwi_0235 28 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 75674578 Nonpathogen - hypothetical protein Nwi_0380 1 None None None 75675837 Common - RecJ exonuclease Nwi_1645 193 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 75674631 Common - F0F1 ATP synthase subunit beta Nwi_0433 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 75675215 Nonpathogen - hypothetical protein Nwi_1022 1 None None None 75676467 Common - FAD dependent oxidoreductase Nwi_2282 133 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 75674220 Common - hypothetical protein Nwi_0021 165 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 75676333 Common - drug resistance transporter EmrB/QacA subfamily Nwi_2148 196 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 75675884 Common rpsR 30S ribosomal protein S18 Nwi_1692 215 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 75677200 Common - YcjX-like protein Nwi_3019 42 COG3106 COG3106, Predicted ATPase General function prediction only 75675239 Common murE UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase Nwi_1046 208 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 75675636 Common - Nitrogen regulation protein ntrB Nwi_1444 222 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 75677128 Common - N-formylglutamate amidohydrolase Nwi_2947 58 COG3741 HutG, N-formylglutamate amidohydrolase Amino acid transport and metabolism 75674908 Common - Protein of unknown function DUF59 Nwi_0711 145 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 75674545 Common - Signal transduction histidine kinase Nwi_0347 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 75676275 Common - hypothetical protein Nwi_2087 2 None None None 75675861 Common - hypothetical protein Nwi_1669 34 None None None 75676950 Nonpathogen - hypothetical protein Nwi_2766 1 None None None 75675319 Common - hypothetical protein Nwi_1126 15 COG3334 COG3334, Uncharacterized conserved protein Function unknown 75675339 Nonpathogen - hypothetical protein Nwi_1146 1 None None None 75676559 Nonpathogen - hypothetical protein Nwi_2374 1 None None None 75676538 Common fumC fumarate hydratase Nwi_2353 213 COG0114 FumC, Fumarase Energy production and conversion 75674806 Common - acyl-CoA dehydrogenase Nwi_0608 157 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 75675437 Common - 3-oxoacyl-(acyl carrier protein) synthase II Nwi_1244 173 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 75676822 Common - hypothetical protein Nwi_2638 30 None None None 75674491 Common - Cell wall-associated hydrolase Nwi_0293 97 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 75674879 Common - alkanesulfonate monooxygenase Nwi_0682 81 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 75674297 Common trmE tRNA modification GTPase TrmE Nwi_0098 216 COG0486 ThdF, Predicted GTPase General function prediction only 75674730 Common - cobyrinic acid a,c-diamide synthase Nwi_0532 148 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 75674584 Common - methyltransferase Nwi_0386 80 None None None 75674848 Common - hypothetical protein Nwi_0651 79 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 75674824 Common - Autoinducer synthesis protein Nwi_0626 25 COG3916 LasI, N-acyl-L-homoserine lactone synthetase Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 75676191 Common gatA aspartyl/glutamyl-tRNA amidotransferase subunit A Nwi_2001 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 75674343 Common - Electron transport protein SCO1/SenC Nwi_0144 108 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 75677132 Common - Lysophospholipase Nwi_2951 72 COG2267 PldB, Lysophospholipase Lipid metabolism 75675488 Common - integrase, catalytic region Nwi_1296 62 None None None 75676634 Common greA transcription elongation factor GreA Nwi_2450 204 COG0782 GreA, Transcription elongation factor Transcription 75676881 Common - FAD linked oxidase Nwi_2697 199 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 75675365 Common - Phage conserved hypothetical protein, phiE125 gp8 Nwi_1172 21 None None None 75676584 Nonpathogen - hypothetical protein Nwi_2399 2 COG3501 VgrG, Uncharacterized protein conserved in bacteria Function unknown 75675521 Common - GTP cyclohydrolase I Nwi_1329 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 75676359 Common - hypothetical protein Nwi_2174 8 None None None 75675358 Nonpathogen - hypothetical protein Nwi_1165 1 None None None 75675436 Common - 3-oxoacyl-(acyl carrier protein) synthase II Nwi_1243 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 75676643 Nonpathogen - hypothetical protein Nwi_2459 5 None None None 75675680 Nonpathogen - hypothetical protein Nwi_1488 1 None None None 75674386 Common - DEAD/DEAH box helicase Nwi_0187 178 COG1201 Lhr, Lhr-like helicases General function prediction only 75677092 Common - heavy metal efflux pump CzcA Nwi_2911 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 75675789 Common - phosphoribosylaminoimidazole synthetase Nwi_1597 231 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 75676990 Common - Conserved hypothetical protein 48 Nwi_2806 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 75676254 Common - sulfate transporter/antisigma-factor antagonist STAS Nwi_2065 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 75676611 Common - nicotinate-nucleotide pyrophosphorylase Nwi_2426 204 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 75675892 Common - Heat shock protein DnaJ Nwi_1700 25 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 75674371 Common - hypothetical protein Nwi_0172 25 COG5375 COG5375, Uncharacterized protein conserved in bacteria Function unknown 75675194 Common - phosphoribosylaminoimidazole carboxylase, ATPase subunit Nwi_1001 192 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 75676681 Nonpathogen - hypothetical protein Nwi_2497 4 None None None 75676512 Common - hypothetical protein Nwi_2327 72 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 75676130 Common - CRISPR-associated CT1133 family protein Nwi_1939 29 None None None 75675177 Common - TPR repeat protein Nwi_0984 29 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 75675408 Common - ATP-binding protein involved in chromosome partitioning Nwi_1215 229 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 75676400 Common - peptidase S58, DmpA Nwi_2215 51 COG3191 DmpA, L-aminopeptidase/D-esterase Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 75674559 Common - phosphoglucomutase/phosphomannomutase Nwi_0361 226 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 75675205 Common - Signal transduction histidine kinase Nwi_1012 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 162139851 Common - intracellular septation protein A Nwi_0317 92 COG2917 COG2917, Intracellular septation protein A Cell division and chromosome partitioning 75676762 Nonpathogen - hypothetical protein Nwi_2578 1 None None None 75674498 Common - pilus assembly protein CpaD Nwi_0300 14 COG5461 COG5461, Type IV pili component Cell motility and secretion 75675758 Common - single-strand DNA-binding protein Nwi_1566 209 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 75676856 Nonpathogen - hypothetical protein Nwi_2672 1 None None None 75675275 Common - phosphomethylpyrimidine kinase Nwi_1082 218 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 75677007 Common - transposase Nwi_2823 76 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676860 Nonpathogen - hypothetical protein Nwi_2676 4 None None None 75674697 Nonpathogen - hypothetical protein Nwi_0499 1 None None None 75674739 Common - glycosyl transferase, family 2 Nwi_0541 17 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 75674945 Common - Signal transduction histidine kinase Nwi_0749 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 75676474 Common - HpcH/HpaI aldolase Nwi_2289 111 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 75676305 Common - transposase IS3/IS911 Nwi_2119 49 None None None 75677186 Nonpathogen - hypothetical protein Nwi_3005 1 None None None 75674452 Common - helix-turn-helix, Fis-type Nwi_0254 192 COG1475 Spo0J, Predicted transcriptional regulators Transcription 75675645 Common - ExsB Nwi_1453 172 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 75675561 Common rplV 50S ribosomal protein L22 Nwi_1369 216 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 75676187 Common gatB aspartyl/glutamyl-tRNA amidotransferase subunit B Nwi_1997 213 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 75675653 Common - TatD-related deoxyribonuclease Nwi_1461 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 75674794 Common - flagellar motor switch protein Nwi_0596 126 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 75674432 Common - transposase Nwi_0233 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676192 Nonpathogen - hypothetical protein Nwi_2002 3 None None None 75674409 Common - Conserved hypothetical protein FYDLN acid Nwi_0210 18 COG4530 COG4530, Uncharacterized protein conserved in bacteria Function unknown 75677210 Common - Peptidase C14 Nwi_3029 68 COG4249 COG4249, Uncharacterized protein containing caspase domain General function prediction only 75674464 Common - hypothetical protein Nwi_0266 4 COG2405 COG2405, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 75675330 Common flhB flagellar biosynthesis protein FlhB Nwi_1137 130 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 75675465 Common - hypothetical protein Nwi_1273 15 COG5653 COG5653, Protein involved in cellulose biosynthesis (CelD) Cell envelope biogenesis, outer membrane 75675840 Common - aminotransferase Nwi_1648 237 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 75676945 Common - phosphoadenosine phosphosulfate reductase Nwi_2761 147 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 75676914 Common - Conserved hypothetical protein 282 Nwi_2730 81 COG1692 COG1692, Uncharacterized protein conserved in bacteria Function unknown 75676245 Nonpathogen - hypothetical protein Nwi_2056 1 None None None 75674420 Common - peptidase U62, modulator of DNA gyrase Nwi_0221 170 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 75675855 Common - FeS assembly ATPase SufC Nwi_1663 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 75676999 Common - hypothetical protein Nwi_2815 27 COG5266 CbiK, ABC-type Co2+ transport system, periplasmic component Inorganic ion transport and metabolism 75676533 Common - HflC Nwi_2348 215 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 75675455 Nonpathogen - transcriptional regulator, XRE family Nwi_1263 5 COG1396 HipB, Predicted transcriptional regulators Transcription 75675994 Common - multiple antibiotic resistance (MarC)-related proteins Nwi_1802 114 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 75675004 Common - Phage portal protein, lambda Nwi_0808 35 COG5511 COG5511, Bacteriophage capsid protein General function prediction only 75675210 Common - transposase IS3/IS911 Nwi_1017 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75677076 Common - beta-lactamase-like protein Nwi_2895 208 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 75674258 Common - peptidase S49, SppA Nwi_0059 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 75675776 Common - hypothetical protein Nwi_1584 30 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 75675872 Common - hypothetical protein Nwi_1680 65 None None None 75677285 Nonpathogen - hypothetical protein Nwi_3107 2 None None None 75677078 Common - hypothetical protein Nwi_2897 25 None None None 75676299 Common groEL chaperonin GroEL Nwi_2113 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 75675478 Common - glycine cleavage system T protein Nwi_1286 178 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 75674234 Common - ferric-uptake regulator Nwi_0035 119 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 75674901 Common - Biopolymer transport protein ExbD/TolR Nwi_0704 136 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 75674978 Common - integrase, catalytic region Nwi_0782 113 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676806 Common - polynucleotide adenylyltransferase region Nwi_2622 177 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 75674788 Common - sulphite reductase (NADPH) flavoprotein, alpha chain Nwi_0590 107 COG0369 CysJ, Sulfite reductase, alpha subunit (flavoprotein) Inorganic ion transport and metabolism 75676710 Common uvrC excinuclease ABC subunit C Nwi_2526 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 75675744 Nonpathogen - hypothetical protein Nwi_1552 1 None None None 162139841 Common - transposase IS3/IS911 Nwi_2357 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676303 Common - Heat shock protein Hsp20 Nwi_2117 73 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 75675937 Common - indolepyruvate ferredoxin oxidoreductase Nwi_1745 88 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 75676916 Common - Protein of unknown function DUF710 Nwi_2732 24 COG3027 COG3027, Uncharacterized protein conserved in bacteria Function unknown 75674217 Common lnt apolipoprotein N-acyltransferase Nwi_0018 165 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 75677094 Common - two component transcriptional regulatory protein, winged-helix family Nwi_2913 208 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 75677175 Common - acetyl-CoA acetyltransferase Nwi_2994 169 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 75677228 Common - ABC-type Fe3+-siderophore transport system permease component Nwi_3048 189 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 75676448 Common - aminotransferase class-III Nwi_2263 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 75674763 Common - Transcriptional regulatory protein, MarR family Nwi_0565 20 COG1846 MarR, Transcriptional regulators Transcription 75674550 Common - arginase Nwi_0352 88 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 75674965 Common - cytochrome o ubiquinol oxidase subunit III Nwi_0769 66 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 75674991 Common - hypothetical protein Nwi_0795 30 COG5449 COG5449, Uncharacterized conserved protein Function unknown 75677169 Common - Oxidoreductase, molybdopterin binding Nwi_2988 82 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 75676048 Common - uridylate kinase Nwi_1857 246 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 75674981 Nonpathogen - hypothetical protein Nwi_0785 2 None None None 75675088 Common - hypothetical protein Nwi_0893 48 COG3832 COG3832, Uncharacterized conserved protein Function unknown 75677233 Common - major facilitator superfamily MFS_1 Nwi_3053 108 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 75676618 Common - helix-turn-helix, Fis-type Nwi_2433 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676650 Common thiG thiazole synthase Nwi_2466 166 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 75676929 Common - GCN5-related N-acetyltransferase Nwi_2745 23 COG0456 RimI, Acetyltransferases General function prediction only 75676132 Common - CRISPR-associated helicase Cas3, core Nwi_1941 70 COG1203 COG1203, Predicted helicases General function prediction only 75674504 Common - Flp pilus assembly protein TadG Nwi_0306 20 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 75677314 Nonpathogen - phage integrase Nwi_3136 3 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 75676104 Common - arsenate reductase Nwi_1913 107 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 75674850 Common - beta-lactamase Nwi_0653 120 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 75675096 Common - hypothetical protein Nwi_0903 8 COG4430 COG4430, Uncharacterized protein conserved in bacteria Function unknown 75676721 Common - beta alanine--pyruvate transaminase Nwi_2537 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 75676066 Common - NADH dehydrogenase subunit M Nwi_1875 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 75676623 Nonpathogen - hypothetical protein Nwi_2439 1 None None None 75677252 Common - GTPase EngB Nwi_3073 187 COG0218 COG0218, Predicted GTPase General function prediction only 75675044 Common - conjugal transfer protein precursor Nwi_0849 31 COG4959 TraF, Type IV secretory pathway, protease TraF Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 75675821 Common - RecA-family ATPase Nwi_1629 4 COG3598 RepA, RecA-family ATPase DNA replication, recombination, and repair 75676407 Nonpathogen - hypothetical protein Nwi_2222 7 None None None 75675839 Common - homoserine dehydrogenase Nwi_1647 217 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 75675805 Nonpathogen - hypothetical protein Nwi_1613 1 None None None 75676503 Common - TonB-dependent siderophore receptor Nwi_2318 121 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 75674829 Common - possible hypothetical RNA methyltransferase Nwi_0631 188 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 75675457 Common - Acriflavin resistance protein Nwi_1265 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 75675110 Common - Cobalamin synthesis protein, CobW Nwi_0917 126 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 75675763 Common - ribonucleotide-diphosphate reductase subunit alpha Nwi_1571 162 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 75677162 Common - glutathione S-transferase Nwi_2981 103 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 75674813 Common - Trancriptional regulatory protein, LysR family Nwi_0615 150 COG0583 LysR, Transcriptional regulator Transcription 75676390 Common - Aerobic-type carbon monoxide dehydrogenase small subunit CoxS/CutS Nwi_2205 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 75675282 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Nwi_1089 246 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 75674335 Common - acyltransferase 3 Nwi_0136 33 COG4645 COG4645, Uncharacterized protein conserved in bacteria Function unknown 75674867 Common - Cytochrome c553 Nwi_0670 56 COG2863 COG2863, Cytochrome c553 Energy production and conversion 75675399 Common - glycogen debranching enzyme GlgX Nwi_1206 163 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 162139846 Common rplM 50S ribosomal protein L13 Nwi_1421 225 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 75676639 Common - cobyrinic acid a,c-diamide synthase Nwi_2455 133 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 75674417 Common - PfkB Nwi_0218 191 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 75676567 Common purU formyltetrahydrofolate deformylase Nwi_2382 218 COG0788 PurU, Formyltetrahydrofolate hydrolase Nucleotide transport and metabolism 75674916 Common - BFD-like (2Fe-2S)-binding region Nwi_0719 190 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 75674604 Common rpmB 50S ribosomal protein L28 Nwi_0406 139 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 75675277 Nonpathogen - hypothetical protein Nwi_1084 5 None None None 75676702 Common - Two-component transcriptional regulator, winged helix family Nwi_2518 213 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 75676508 Common - ABC-type Fe3+-siderophore transport system permease component Nwi_2323 191 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 75676239 Common - Probable FecR, iron siderophore sensor protein Nwi_2050 47 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 75676782 Common - ribonuclease HII/HIII Nwi_2598 215 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 75676804 Common - 6-pyruvoyl tetrahydropterin synthase Nwi_2620 94 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 75675449 Nonpathogen - hypothetical protein Nwi_1257 3 None None None 75675165 Common - transposase Nwi_0972 76 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675012 Common - ParB-like nuclease Nwi_0816 34 COG1475 Spo0J, Predicted transcriptional regulators Transcription 75675005 Common - hypothetical protein Nwi_0809 4 None None None 75674662 Common - dihydroorotate dehydrogenase 2 Nwi_0464 226 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 75674535 Common - potassium/proton antiporter Nwi_0337 127 COG3263 COG3263, NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain Inorganic ion transport and metabolism 75674858 Common - TonB-dependent receptor Nwi_0661 85 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 75675416 Common - glutathione reductase Nwi_1223 245 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 75675576 Common secY preprotein translocase subunit SecY Nwi_1384 235 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 75675928 Common - Propionyl-coenzyme A carboxylase alpha polypeptide Nwi_1736 238 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 75675900 Common - Protein of unknown function DUF218 Nwi_1708 103 COG1434 COG1434, Uncharacterized conserved protein Function unknown 75676178 Common - Transcriptional regulatory protein, LysR family Nwi_1988 192 COG0583 LysR, Transcriptional regulator Transcription 75676063 Common - hydrolase of the metallo-beta-lactamase superfamily Nwi_1872 150 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 75675567 Common rplX 50S ribosomal protein L24 Nwi_1375 212 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 75675583 Common - peptidase S1C, Do Nwi_1391 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 75677102 Common - ISRm2011-2 transposase protein Nwi_2921 45 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676399 Common - Cytochrome c biogenesis protein, transmembrane region Nwi_2214 102 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 75675145 Common - Universal stress protein, UspA Nwi_0952 43 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 75676550 Common - FAD dependent oxidoreductase Nwi_2365 57 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 75677119 Common - hypothetical protein Nwi_2938 9 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 75675079 Nonpathogen - hypothetical protein Nwi_0884 2 None None None 75677219 Common - transposase Nwi_3038 76 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674431 Common - probable ISRm2011-2 transposase protein Nwi_0232 40 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676575 Common - histidine biosynthesis Nwi_2390 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 75674534 Common - peptidase M24A, methionine aminopeptidase, subfamily 1 Nwi_0336 248 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 75675707 Common - DEAD/DEAH box helicase Nwi_1515 210 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 75676505 Common - small multidrug resistance protein Nwi_2320 120 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 75676805 Common - coproporphyrinogen III oxidase Nwi_2621 112 COG0408 HemF, Coproporphyrinogen III oxidase Coenzyme metabolism 75674510 Common - translation initiation factor IF-1 Nwi_0312 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 75675047 Common - transposase Nwi_0852 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674255 Common - N-(5'-phosphoribosyl)anthranilate isomerase Nwi_0056 197 COG0135 TrpF, Phosphoribosylanthranilate isomerase Amino acid transport and metabolism 75675949 Common aat leucyl/phenylalanyl-tRNA--protein transferase Nwi_1757 134 COG2360 Aat, Leu/Phe-tRNA-protein transferase Posttranslational modification, protein turnover, chaperones 75676714 Common - hypothetical protein Nwi_2530 10 None None None 75674426 Common - cytochrome C oxidase assembly protein Nwi_0227 68 COG3175 COX11, Cytochrome oxidase assembly factor Posttranslational modification, protein turnover, chaperones 75674463 Common - transcriptional regulator, XRE family Nwi_0265 18 COG2856 COG2856, Predicted Zn peptidase Amino acid transport and metabolism 75675767 Common - polyphosphate glucokinase Nwi_1575 34 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 75675075 Common - hypothetical protein Nwi_0880 37 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 75674390 Common - coproporphyrinogen III oxidase Nwi_0191 204 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 75674272 Common - thioredoxin-related Nwi_0073 217 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 75674521 Common - aconitate hydratase Nwi_0323 223 COG1048 AcnA, Aconitase A Energy production and conversion 75675014 Common - hypothetical protein Nwi_0818 11 None None None 75675551 Common rpsL 30S ribosomal protein S12 Nwi_1359 242 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 75676445 Common - probable ISRm2011-2 transposase protein Nwi_2260 45 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675456 Nonpathogen - hypothetical protein Nwi_1264 1 None None None 75676829 Common - carbohydrate kinase, thermoresistant glucokinase Nwi_2645 80 COG3265 GntK, Gluconate kinase Carbohydrate transport and metabolism 75675936 Common - Signal transduction histidine kinase Nwi_1744 211 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 75676491 Common - Biopolymer transport protein ExbD/TolR Nwi_2306 104 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 75675274 Common - probable transcriptional regulator Nwi_1081 19 COG1522 Lrp, Transcriptional regulators Transcription 75676488 Common - Fec I like protein Nwi_2303 81 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75675440 Nonpathogen - hypothetical protein Nwi_1247 3 None None None 75675554 Common - elongation factor Tu Nwi_1362 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 75675854 Common - FeS assembly protein SufD Nwi_1662 174 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 75675873 Common pdxA 4-hydroxythreonine-4-phosphate dehydrogenase Nwi_1681 159 COG1995 PdxA, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 75676729 Common - peptidase M16 Nwi_2545 202 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 75676836 Nonpathogen - Cytochrome c biogenesis factor Nwi_2652 2 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 75674508 Common - transposase, IS4 Nwi_0310 66 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675298 Common - hypothetical protein Nwi_1105 53 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 75674633 Common - transposase, IS4 Nwi_0435 62 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75677211 Common - Secretion protein HlyD Nwi_3030 114 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 75677098 Common - integrase, catalytic region Nwi_2917 62 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 75676273 Nonpathogen - hypothetical protein Nwi_2085 1 None None None 75675006 Common - phage terminase GpA Nwi_0810 37 COG5525 COG5525, Bacteriophage tail assembly protein General function prediction only 75675287 Common - phosphoglycerate/bisphosphoglycerate mutase Nwi_1094 69 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 75675638 Common - Nitrogen regulatory signal transduction histidine kinase NtrY Nwi_1446 181 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 75676797 Common - adenine phosphoribosyltransferase Nwi_2613 189 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 75677024 Common - resolvase Nwi_2841 88 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 75675400 Common - glycogen branching enzyme Nwi_1207 153 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 75674723 Common - Transcriptional regulatory protein Nwi_0525 214 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 75676547 Common - ABC transporter, inner membrane subunit Nwi_2362 152 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 75675280 Nonpathogen - Hpt protein Nwi_1087 3 COG2198 ArcB, FOG: HPt domain Signal transduction mechanisms 75677266 Common - hypothetical protein Nwi_3088 9 None None None 75674680 Common - transposase Nwi_0482 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676237 Common - Fec I like protein Nwi_2048 7 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75674337 Common - Lysophospholipase L1 and related esterase Nwi_0138 11 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 75675826 Nonpathogen - hypothetical protein Nwi_1634 1 None None None 75675209 Common - ISRm2011-2 transposase protein Nwi_1016 45 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676756 Nonpathogen - hypothetical protein Nwi_2572 5 None None None 75676224 Nonpathogen - hypothetical protein Nwi_2034 4 None None None 75676588 Common - Membrane protein involved in the export of O-antigen and teichoic acid Nwi_2403 3 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 75674397 Common - Heat shock protein DnaJ Nwi_0198 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 75677165 Nonpathogen - hypothetical protein Nwi_2984 3 None None None 75677045 Common - transposase IS3/IS911 Nwi_2864 33 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75677257 Nonpathogen - hypothetical protein Nwi_3078 1 None None None 75676078 Common - NADH dehydrogenase subunit B Nwi_1887 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 75676120 Common dapA dihydrodipicolinate synthase Nwi_1929 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 75675571 Common rplF 50S ribosomal protein L6 Nwi_1379 244 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 75676651 Common - thiamine monophosphate synthase Nwi_2467 199 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 75674995 Common - hypothetical protein Nwi_0799 4 None None None 75677116 Common - hypothetical protein Nwi_2935 8 None None None 75675955 Common - hypothetical protein Nwi_1763 37 COG5473 COG5473, Predicted integral membrane protein Function unknown 162139844 Common - riboflavin synthase subunit alpha Nwi_1724 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 75675940 Common - aminotransferase, class I and II Nwi_1748 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 75676243 Nonpathogen - hypothetical protein Nwi_2054 1 None None None 75675924 Common - TonB-dependent siderophore receptor Nwi_1732 95 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 75676193 Common gatC aspartyl/glutamyl-tRNA amidotransferase subunit C Nwi_2003 154 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 75677174 Common - 3-hydroxyacyl-CoA dehydrogenase NAD-binding Nwi_2993 176 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 75674580 Common - Protein of unknown function DUF1178 Nwi_0382 47 COG5319 COG5319, Uncharacterized protein conserved in bacteria Function unknown 75675716 Common - RND efflux system, outer membrane lipoprotein, NodT Nwi_1524 132 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 75676056 Common - prolyl-tRNA synthetase Nwi_1865 247 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 75676868 Common - acyl-CoA synthetase Nwi_2684 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 75676919 Common - glyceraldehyde-3-phosphate dehydrogenase Nwi_2735 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 75674267 Common rpmI 50S ribosomal protein L35 Nwi_0068 138 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 75677227 Nonpathogen - hypothetical protein Nwi_3047 3 None None None 75676439 Common - threonine dehydratase Nwi_2254 195 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 75674494 Common - type II secretion system protein Nwi_0296 54 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion 75676024 Common - CTP synthetase Nwi_1833 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 75675261 Common - phosphoheptose isomerase Nwi_1068 124 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 75677005 Common - ISBm1, transposase orfA Nwi_2821 70 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674666 Common - Protein of unknown function DUF589 Nwi_0468 94 COG2947 COG2947, Uncharacterized conserved protein Function unknown 75676326 Common - prophage CP4-57 regulatory Nwi_2141 20 COG3311 AlpA, Predicted transcriptional regulator Transcription 75674787 Common - AAA ATPase Nwi_0589 215 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 75676604 Common - adenosylmethionine--8-amino-7-oxononanoate transaminase Nwi_2419 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 75677234 Common - Cold-shock protein, DNA-binding Nwi_3054 178 COG1278 CspC, Cold shock proteins Transcription 75674569 Nonpathogen - hypothetical protein Nwi_0371 9 None None None 75676456 Common - squalene/phytoene synthase Nwi_2271 99 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 75674379 Common - transposase, IS4 Nwi_0180 62 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676745 Common - hypothetical protein Nwi_2561 8 None None None 75674856 Common - transposase IS3/IS911 Nwi_0659 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674618 Common sucC succinyl-CoA synthetase subunit beta Nwi_0420 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 75674414 Common - transposase IS4 family Nwi_0215 50 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675159 Nonpathogen - hypothetical protein Nwi_0966 3 None None None 75675009 Nonpathogen - hypothetical protein Nwi_0813 1 None None None 75674282 Common - cell division protein FtsK/SpoIIIE Nwi_0083 197 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 75675505 Common - hypothetical protein Nwi_1313 5 None None None 75674678 Common - tetrahydrofolate dehydrogenase/cyclohydrolase Nwi_0480 223 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 75676189 Common - ISRm2011-2 transposase protein Nwi_1999 45 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75677287 Common - resolvase Nwi_3109 71 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 75675617 Common - Protein of unknown function DUF482 Nwi_1425 81 COG3146 COG3146, Uncharacterized protein conserved in bacteria Function unknown 75676293 Common - transposase Nwi_2107 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75677054 Nonpathogen - hypothetical protein Nwi_2873 6 None None None 75674830 Common - hemolysin A Nwi_0632 132 COG1189 COG1189, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 75676785 Common - molybdopterin biosynthesis protein B Nwi_2601 121 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 75674889 Common - pyrroloquinoline quinone biosynthesis protein PqqB Nwi_0692 35 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 75675108 Common - ABC-type Mn2+/Zn2+ transport systems permease components Nwi_0915 188 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 75675458 Common - Secretion protein HlyD Nwi_1266 163 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 75675743 Common - hypothetical protein Nwi_1551 9 None None None 75676218 Common - sugE protein, small multidrug resistance protein, SMR family Nwi_2028 71 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 75675163 Nonpathogen - hypothetical protein Nwi_0970 1 None None None 75675168 Common - SirA-like protein Nwi_0975 67 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 75675587 Common - transposase Nwi_1395 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675276 Common - metallophosphoesterase Nwi_1083 66 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 75676734 Common - pseudouridine synthase, Rsu Nwi_2550 205 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 75675211 Common - helix-turn-helix, Fis-type Nwi_1018 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676892 Common - cell wall hydrolase, SleB Nwi_2708 45 COG3773 SleB, Cell wall hydrolyses involved in spore germination Cell envelope biogenesis, outer membrane 75675650 Common - alkylhydroperoxidase AhpD core Nwi_1458 62 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 75674332 Common - PII uridylyl-transferase Nwi_0133 126 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 75674821 Common - hypothetical protein Nwi_0623 16 None None None 75675381 Common - Signal transduction histidine kinase Nwi_1188 198 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 75674449 Common - Helicase Nwi_0251 194 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 75676724 Common - response regulator receiver Nwi_2540 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 75677137 Common - hypothetical protein Nwi_2956 23 COG2845 COG2845, Uncharacterized protein conserved in bacteria Function unknown 75676993 Common phhB pterin-4-alpha-carbinolamine dehydratase Nwi_2809 106 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 75676670 Nonpathogen - hypothetical protein Nwi_2486 3 None None None 75675337 Common - transposase IS3/IS911 Nwi_1144 33 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675417 Common - dAHP synthetase, class II Nwi_1224 73 COG3200 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 75676888 Common - Glycine cleavage T protein (aminomethyl transferase) Nwi_2704 129 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 75676766 Common - cytochrome c, class I Nwi_2582 57 COG3474 COG3474, Cytochrome c2 Energy production and conversion 75675360 Common - Phage major capsid protein, HK97 Nwi_1167 53 COG4653 COG4653, Predicted phage phi-C31 gp36 major capsid-like protein General function prediction only 75674560 Common - Transcriptional regulatory proteins, AsnC/Lrp family Nwi_0362 154 COG1522 Lrp, Transcriptional regulators Transcription 75674861 Common - putative porin Nwi_0664 15 None None None 75674709 Common - phosphate regulon transcriptional regulatory protein phoB Nwi_0511 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 75676803 Common - hypothetical protein Nwi_2619 145 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 75676109 Common - ribonuclease III Nwi_1918 215 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 75676662 Nonpathogen - hypothetical protein Nwi_2478 2 None None None 75674754 Common - response regulator receiver Nwi_0556 67 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 75677145 Common - hypothetical protein Nwi_2964 13 None None None 75674548 Common - phosphoenolpyruvate carboxykinase Nwi_0350 98 COG1866 PckA, Phosphoenolpyruvate carboxykinase (ATP) Energy production and conversion 75675771 Common - hypothetical protein Nwi_1579 14 COG5482 COG5482, Uncharacterized conserved protein Function unknown 75674796 Common fliG flagellar motor switch protein G Nwi_0598 125 COG1536 FliG, Flagellar motor switch protein Cell motility and secretion 75675867 Common - DNA polymerase III subunit chi Nwi_1675 38 COG2927 HolC, DNA polymerase III, chi subunit DNA replication, recombination, and repair 75676536 Common thyA thymidylate synthase Nwi_2351 143 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 75674468 Common - DEAD/DEAH box helicase Nwi_0270 130 COG4096 HsdR, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 75674295 Common - Glucose inhibited division protein Nwi_0096 188 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 75677111 Common - Transcriptional regulatory protein, LysR family Nwi_2930 192 COG0583 LysR, Transcriptional regulator Transcription 75675182 Common - hypothetical protein Nwi_0989 38 COG3750 COG3750, Uncharacterized protein conserved in bacteria Function unknown 75676679 Common - excinuclease ABC subunit B Nwi_2495 224 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 75675198 Common - FAD dependent oxidoreductase Nwi_1005 95 COG0579 COG0579, Predicted dehydrogenase General function prediction only 75675289 Common - ISBm1, transposase orfA Nwi_1096 78 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676910 Common ruvC Holliday junction resolvase Nwi_2726 198 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 75675976 Common - UDP-N-acetylglucosamine pyrophosphorylase Nwi_1784 236 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 75676362 Nonpathogen - hypothetical protein Nwi_2177 7 None None None 75674801 Common trmU tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Nwi_0603 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 75675023 Nonpathogen - hypothetical protein Nwi_0827 2 None None None 75676252 Nonpathogen - hypothetical protein Nwi_2063 3 None None None 75674221 Common nusA transcription elongation factor NusA Nwi_0022 218 COG0195 NusA, Transcription elongation factor Transcription 75677001 Common - tRNA-dihydrouridine synthase A Nwi_2817 208 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 75676464 Common - cytochrome P450 Nwi_2279 84 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 75677040 Common - ParB-like nuclease Nwi_2859 37 COG1475 Spo0J, Predicted transcriptional regulators Transcription 75674368 Common - Protein of unknown function DUF88 Nwi_0169 67 COG1432 COG1432, Uncharacterized conserved protein Function unknown 75674204 Nonpathogen - hypothetical protein Nwi_0005 6 None None None 75675566 Common rplN 50S ribosomal protein L14 Nwi_1374 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 75676250 Common - Transcriptional regulatory protein, Crp family Nwi_2061 109 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 75674874 Common - 4Fe-4S ferredoxin, iron-sulfur binding Nwi_0677 35 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 75675170 Common hemE uroporphyrinogen decarboxylase Nwi_0977 179 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 75675363 Nonpathogen - hypothetical protein Nwi_1170 4 None None None 75676631 Common - ferritin and Dps Nwi_2447 134 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 75675560 Common rpsS 30S ribosomal protein S19 Nwi_1368 242 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 75674843 Nonpathogen - hypothetical protein Nwi_0646 6 None None None 75675050 Common - hypothetical protein Nwi_0855 26 None None None 75675787 Common - hypothetical protein Nwi_1595 80 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 75675700 Common - hemimethylated DNA-binding region Nwi_1508 34 COG3785 COG3785, Uncharacterized conserved protein Function unknown 75675222 Common - Signal transduction histidine kinase Nwi_1029 221 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 75677109 Common - ribulose bisphosphate carboxylase, small chain Nwi_2928 29 COG4451 RbcS, Ribulose bisphosphate carboxylase small subunit Energy production and conversion 75674301 Common - hypothetical protein Nwi_0102 112 COG1806 COG1806, Uncharacterized protein conserved in bacteria Function unknown 75676760 Common - hypothetical protein Nwi_2576 2 None None None 75676943 Common - Sulfate ABC transporter, permease protein CysT Nwi_2759 238 COG0555 CysU, ABC-type sulfate transport system, permease component Posttranslational modification, protein turnover, chaperones 75675052 Common - PilT protein Nwi_0857 54 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 75676337 Common - hypothetical protein Nwi_2152 97 COG1671 COG1671, Uncharacterized protein conserved in bacteria Function unknown 75675655 Common - DNA polymerase III subunit delta' Nwi_1463 213 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 75675230 Nonpathogen - hypothetical protein Nwi_1037 1 None None None 75674885 Common - 3-demethylubiquinone-9 3-methyltransferase Nwi_0688 63 COG3865 COG3865, Uncharacterized protein conserved in bacteria Function unknown 75674279 Nonpathogen - hypothetical protein Nwi_0080 1 None None None 75674293 Common - ParB-like partition protein Nwi_0094 185 COG1475 Spo0J, Predicted transcriptional regulators Transcription 75675641 Common hfq RNA-binding protein Hfq Nwi_1449 127 COG1923 Hfq, Uncharacterized host factor I protein General function prediction only 75675250 Common - Cell division protein FtsA Nwi_1057 179 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 75675290 Common - integrase, catalytic region Nwi_1097 62 None None None 75676577 Common - LPS biosynthesis protein Nwi_2392 26 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 75677274 Nonpathogen - hypothetical protein Nwi_3096 1 None None None 75675889 Common - hypothetical protein Nwi_1697 18 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 75677104 Common - transposase, IS4 Nwi_2923 62 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75677273 Nonpathogen - hypothetical protein Nwi_3095 2 None None None 75676345 Common - acetyl-CoA acetyltransferase Nwi_2160 104 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 75677192 Nonpathogen - hypothetical protein Nwi_3011 2 None None None 75676566 Nonpathogen - hypothetical protein Nwi_2381 3 None None None 75676084 Common - peptidase T Nwi_1893 64 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 75674602 Common - cobalt chelatase, CobT subunit Nwi_0404 41 COG4547 CobT, Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) Coenzyme metabolism 75676931 Common rpmE 50S ribosomal protein L31 Nwi_2747 147 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 75677037 Common - GCN5-related N-acetyltransferase Nwi_2856 47 COG0456 RimI, Acetyltransferases General function prediction only 75675147 Common - ISRm2011-2 transposase protein Nwi_0954 45 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676531 Common - peptidase S1C, Do Nwi_2346 221 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 75675126 Common - hypothetical protein Nwi_0933 19 COG1618 COG1618, Predicted nucleotide kinase Nucleotide transport and metabolism 75674923 Common - ferric siderophore receptor Nwi_0726 85 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 75674377 Common - sigma 54 modulation protein/ribosomal protein S30EA Nwi_0178 51 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 75676168 Common - cobyrinic acid a,c-diamide synthase Nwi_1978 173 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 75674815 Common - acyl-CoA synthetase Nwi_0617 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 75676820 Nonpathogen - hypothetical protein Nwi_2636 1 None None None 75674980 Nonpathogen - Prevent-host-death protein Nwi_0784 4 COG2161 StbD, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 75675259 Common - lipopolysaccharide heptosyltransferase I Nwi_1066 96 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 75676843 Common - putative monovalent cation/H+ antiporter subunit G Nwi_2659 13 COG1320 MnhG, Multisubunit Na+/H+ antiporter, MnhG subunit Inorganic ion transport and metabolism 75676905 Common - hypothetical protein Nwi_2721 19 None None None 75676301 Common - hypothetical protein Nwi_2115 9 None None None 75675903 Nonpathogen - hypothetical protein Nwi_1711 3 None None None 75674280 Common - ISSpo8, transposase Nwi_0081 33 COG3677 COG3677, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676053 Common - orotidine 5'-phosphate decarboxylase Nwi_1862 175 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 75676938 Common - Polysaccharide biosynthesis protein Nwi_2754 49 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 75676008 Common - branched-chain alpha-keto acid dehydrogenase subunit E2 Nwi_1816 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 75674563 Common - ISBm1, transposase orfA Nwi_0365 78 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75677290 Common - helix-turn-helix, Fis-type Nwi_3112 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674313 Common - Signal transduction histidine kinase Nwi_0114 223 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 75675335 Nonpathogen - hypothetical protein Nwi_1142 1 None None None 75675896 Nonpathogen - hypothetical protein Nwi_1704 4 None None None 75676960 Common dapF diaminopimelate epimerase Nwi_2776 190 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 75674993 Common - phage-related minor tail protein Nwi_0797 27 COG5281 COG5281, Phage-related minor tail protein Function unknown 75675690 Nonpathogen - hypothetical protein Nwi_1498 3 None None None 75676454 Common - terpene synthase/Squalene cyclase Nwi_2269 41 COG1657 SqhC, Squalene cyclase Lipid metabolism 75674681 Common - ISRm2011-2 transposase protein Nwi_0483 40 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75677030 Common - hypothetical protein Nwi_2849 44 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675785 Common - Ppx/GppA phosphatase Nwi_1593 182 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 75676085 Common - methyltransferase FkbM Nwi_1894 54 COG2242 CobL, Precorrin-6B methylase 2 Coenzyme metabolism 75676403 Common - ribulose-phosphate 3-epimerase Nwi_2218 215 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 75674411 Common - Protein of unknown function DUF1150 Nwi_0212 13 COG5568 COG5568, Uncharacterized small protein Function unknown 75674893 Common - UbiE/COQ5 methyltransferase Nwi_0696 176 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 75674511 Nonpathogen - hypothetical protein Nwi_0313 1 None None None 75677206 Common - glycoside hydrolase 15-related Nwi_3025 72 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 75676772 Nonpathogen - hypothetical protein Nwi_2588 3 None None None 75676872 Common - homoserine kinase Nwi_2688 61 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 75677016 Common - prophage LambdaMc01, site-specific recombinase, resolvase family Nwi_2833 20 None None None 75674596 Nonpathogen - hypothetical protein Nwi_0398 3 None None None 75676314 Common - probably methylase/helicase Nwi_2128 22 COG2263 COG2263, Predicted RNA methylase Translation, ribosomal structure and biogenesis 75676411 Common - ATPase involved in DNA replication initiation Nwi_2226 22 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 75676692 Common - MaoC-like dehydratase Nwi_2508 54 COG2030 MaoC, Acyl dehydratase Lipid metabolism 75676226 Common - nitroreductase Nwi_2036 90 COG0778 NfnB, Nitroreductase Energy production and conversion 75674892 Common - glycosyl transferase, group 1 Nwi_0695 170 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 75676609 Common - quinolinate synthetase Nwi_2424 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 75677245 Common truA tRNA pseudouridine synthase A Nwi_3066 235 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 75675348 Common - hypothetical protein Nwi_1155 3 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 75674475 Common maf Maf-like protein Nwi_0277 198 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 75674989 Nonpathogen - hypothetical protein Nwi_0793 1 None None None 75674270 Common - hypothetical protein Nwi_0071 23 COG3673 COG3673, Uncharacterized conserved protein Function unknown 75676967 Common rplS 50S ribosomal protein L19 Nwi_2783 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 75675969 Common - sec-independent periplasmic protein translocase Nwi_1777 204 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 75674741 Common - UDP-glucose/GDP-mannose dehydrogenase Nwi_0543 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 75675811 Nonpathogen - phage head-tail adaptor, putative Nwi_1619 6 COG5614 COG5614, Bacteriophage head-tail adaptor General function prediction only 75675882 Common - acyl-carrier-protein S-malonyltransferase Nwi_1690 208 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 75677017 Nonpathogen - hypothetical protein Nwi_2834 5 None None None 75675324 Common - hypothetical protein Nwi_1131 11 COG3190 FliO, Flagellar biogenesis protein Cell motility and secretion 75676215 Common - NnrU Nwi_2025 34 COG4094 COG4094, Predicted membrane protein Function unknown 75675061 Common - transposase IS3/IS911 Nwi_0866 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676271 Nonpathogen - hypothetical protein Nwi_2083 3 None None None 75674935 Common - hypothetical protein Nwi_0738 28 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 75676895 Common - tRNA(Ile)-lysidine synthase Nwi_2711 217 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 75675249 Common - Cell division protein FtsQ Nwi_1056 76 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 75676307 Common - antirestriction protein; ArdC Nwi_2121 48 COG4227 COG4227, Antirestriction protein DNA replication, recombination, and repair 75674354 Common - hypothetical protein Nwi_0155 10 COG5508 COG5508, Uncharacterized conserved small protein Function unknown 75677306 Nonpathogen - hypothetical protein Nwi_3128 1 None None None 75675545 Nonpathogen - hypothetical protein Nwi_1353 5 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 75674914 Nonpathogen - hypothetical protein Nwi_0717 4 None None None 75675307 Common - hypothetical protein Nwi_1114 7 None None None 75675207 Nonpathogen - phasin 2 Nwi_1014 9 COG5490 COG5490, Uncharacterized conserved protein Function unknown 75675429 Common - MotA/TolQ/ExbB proton channel Nwi_1236 83 COG1291 MotA, Flagellar motor component Cell motility and secretion 75676795 Common - LemA Nwi_2611 131 COG1704 LemA, Uncharacterized conserved protein Function unknown 75675105 Common - hypothetical protein Nwi_0912 24 COG4731 COG4731, Uncharacterized protein conserved in bacteria Function unknown 75674640 Common obgE GTPase ObgE Nwi_0442 249 COG0536 Obg, Predicted GTPase General function prediction only 75675526 Common - response regulator receiver Nwi_1334 218 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 75675793 Common - nucleoside diphosphate kinase Nwi_1601 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 75675765 Common - transposase IS3/IS911 Nwi_1573 49 None None None 75674644 Common - Iojap-related protein Nwi_0446 200 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 75676664 Common - hypothetical protein Nwi_2480 56 COG2862 COG2862, Predicted membrane protein Function unknown 75674224 Common rbfA ribosome-binding factor A Nwi_0025 140 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 75675463 Common - peptidase M50 Nwi_1271 99 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 75676705 Common - Multi antimicrobial extrusion protein MatE Nwi_2521 150 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 75676329 Common - tRNA and rRNA cytosine-C5-methylase Nwi_2144 205 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 75675154 Common - hypothetical protein Nwi_0961 7 None None None 75675842 Common - Poly(R)-hydroxyalkanoic acid synthase, class I Nwi_1650 73 COG3243 PhaC, Poly(3-hydroxyalkanoate) synthetase Lipid metabolism 75674323 Common hisH imidazole glycerol phosphate synthase subunit HisH Nwi_0124 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 75676659 Common - bacterioferritin Nwi_2475 112 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 75675697 Common - Integral membrane protein TerC Nwi_1505 103 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 75674955 Nonpathogen - hypothetical protein Nwi_0759 1 None None None 75676775 Common - hypothetical protein Nwi_2591 20 None None None 75675912 Common - ribonuclease E and G Nwi_1720 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 75676437 Common - enoyl-CoA hydratase/isomerase Nwi_2252 180 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 75675015 Nonpathogen - hypothetical protein Nwi_0819 1 None None None 75676003 Common - sel1-like repeat protein Nwi_1811 80 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 75675919 Common glyA serine hydroxymethyltransferase Nwi_1727 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 75675926 Common - FecI like protein Nwi_1734 85 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75674753 Common - transcriptional regulatory protein Nwi_0555 32 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 75677296 Nonpathogen - hypothetical protein Nwi_3118 1 None None None 75674422 Common - cytochrome c oxidase, subunit II Nwi_0223 141 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 162139849 Common - chorismate synthase Nwi_0629 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 75674696 Nonpathogen - hypothetical protein Nwi_0498 12 None None None 75676973 Nonpathogen - hypothetical protein Nwi_2789 3 None None None 75677154 Common - phosphoglucosamine mutase Nwi_2973 240 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 75676521 Common - resolvase Nwi_2336 135 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 75675982 Common - hypothetical protein Nwi_1790 13 None None None 75676557 Nonpathogen - hypothetical protein Nwi_2372 2 None None None 75677069 Common - ribonucleotide-diphosphate reductase subunit alpha Nwi_2888 222 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 75674655 Common - ABC-type nitrate/sulfonate/bicarbonate transport systems periplasmic components Nwi_0457 109 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 75675378 Nonpathogen - hypothetical protein Nwi_1185 1 None None None 75674571 Common - beta-lactamase-like protein Nwi_0373 188 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 75676119 Common - large-conductance mechanosensitive channel Nwi_1928 134 COG1970 MscL, Large-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 75676375 Common - hypothetical protein Nwi_2190 24 COG5425 COG5425, Usg protein, probable subunit of phosphoribosylanthranilate isomerase Amino acid transport and metabolism 75674485 Common - cytochrome c, class I Nwi_0287 57 COG3474 COG3474, Cytochrome c2 Energy production and conversion 75674877 Common - ABC-type nitrate/sulfonate/bicarbonate transport systems periplasmic components Nwi_0680 85 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 75675849 Common - DEAD/DEAH box helicase Nwi_1657 226 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 75676350 Common - hypothetical protein Nwi_2165 23 COG4395 COG4395, Uncharacterized protein conserved in bacteria Function unknown 75675195 Common - 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase Nwi_1002 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 75677084 Common - glycosyl hydrolase, BNR repeat Nwi_2903 19 None None None 75676283 Nonpathogen - probable TrbK Nwi_2095 3 None None None 75675495 Common - Protein of unknown function DUF1476 Nwi_1303 27 COG5467 COG5467, Uncharacterized conserved protein Function unknown 75676883 Nonpathogen - hypothetical protein Nwi_2699 6 None None None 75674344 Common - possible glycosyl transferase Nwi_0145 40 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 75674621 Common - dihydrolipoamide acetyltransferase Nwi_0423 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 75675615 Common - lytic transglycosylase, catalytic Nwi_1423 28 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 75674260 Common - hypothetical protein Nwi_0061 31 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 75675668 Nonpathogen - hypothetical protein Nwi_1476 3 None None None 75676207 Common - amidophosphoribosyltransferase Nwi_2017 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 75676528 Common - acetolactate synthase 3 catalytic subunit Nwi_2343 223 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 75674672 Common - HemY protein Nwi_0474 27 COG3898 COG3898, Uncharacterized membrane-bound protein Function unknown 75675093 Common - NAD-dependent epimerase/dehydratase Nwi_0898 214 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 75674732 Common - hypothetical protein Nwi_0534 10 COG4627 COG4627, Uncharacterized protein conserved in bacteria Function unknown 75677096 Common - hypothetical protein Nwi_2915 17 COG4244 COG4244, Predicted membrane protein Function unknown 75677062 Common - TonB-dependent siderophore receptor Nwi_2881 121 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 75675033 Common - integrase, catalytic region Nwi_0838 51 None None None 75676985 Common sdhB succinate dehydrogenase iron-sulfur subunit Nwi_2801 200 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 75675310 Common - Patatin Nwi_1117 153 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 75675963 Common - Protein of unknown function DUF815 Nwi_1771 89 COG2607 COG2607, Predicted ATPase (AAA+ superfamily) General function prediction only 75675373 Common - putative phage cell wall peptidase, NlpC/P60 Nwi_1180 19 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 75675834 Common - tRNA synthetase, class II (D, K and N) Nwi_1642 200 COG2269 COG2269, Truncated, possibly inactive, lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 75675597 Common - hypothetical protein Nwi_1405 23 None None None 75676920 Common pgk phosphoglycerate kinase Nwi_2736 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 75675117 Common - Orn/DAP/Arg decarboxylase 2 Nwi_0924 216 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 75674714 Common - hypothetical protein Nwi_0516 22 COG5400 COG5400, Uncharacterized protein conserved in bacteria Function unknown 75675131 Common - flavin reductase-like, FMN-binding Nwi_0938 107 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 75675141 Nonpathogen - hypothetical protein Nwi_0948 1 None None None 75676621 Common - probable ISRm2011-2 transposase protein Nwi_2437 45 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676698 Common - pyrroline-5-carboxylate reductase Nwi_2514 214 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 75674466 Common - restriction endonuclease S subunits Nwi_0268 79 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 75677316 Common - resolvase Nwi_3138 87 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 75674871 Common - ABC transporter sulfonate/nitrate transport system substrate-binding protein Nwi_0674 80 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 75676838 Common - putative monovalent cation/H+ antiporter subunit A Nwi_2654 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 75675733 Common - helix-turn-helix, Fis-type Nwi_1541 134 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675402 Common - alpha amylase, catalytic region Nwi_1209 74 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 75676582 Common - acylneuraminate cytidylyltransferase Nwi_2397 64 COG1083 NeuA, CMP-N-acetylneuraminic acid synthetase Cell envelope biogenesis, outer membrane 75675245 Common murC UDP-N-acetylmuramate--L-alanine ligase Nwi_1052 210 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 75676042 Common - Outer membrane protein Nwi_1851 160 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 75676723 Common - HAD-superfamily subfamily IIA hydrolase Nwi_2539 64 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 75676145 Nonpathogen - hypothetical protein Nwi_1954 5 None None None 75675817 Common - Phage major capsid protein, HK97 Nwi_1625 55 COG4653 COG4653, Predicted phage phi-C31 gp36 major capsid-like protein General function prediction only 75676500 Nonpathogen - hypothetical protein Nwi_2315 1 None None None 75674777 Common - phospholipid/glycerol acyltransferase Nwi_0579 182 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 75674835 Common - acyl-CoA dehydrogenase Nwi_0637 146 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 75676200 Common - SMF protein Nwi_2010 209 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 75676754 Common - ErfK/YbiS/YcfS/YnhG Nwi_2570 86 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 75676015 Common - hypothetical protein Nwi_1823 7 None None None 75674779 Nonpathogen - hypothetical protein Nwi_0581 7 COG4093 COG4093, Uncharacterized protein conserved in bacteria Function unknown 75676266 Common - IstB-like ATP-binding protein Nwi_2077 88 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 75676430 Common - CsbD-like protein Nwi_2245 56 COG3237 COG3237, Uncharacterized protein conserved in bacteria Function unknown 75676853 Common - Protein of unknown function DUF214 Nwi_2669 45 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 75674473 Common - phage integrase Nwi_0275 21 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 75676433 Common - RNA polymerase sigma factor Nwi_2248 173 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75677022 Common - integrase, catalytic region Nwi_2839 46 None None None 75674399 Common - NADPH-dependent FMN reductase Nwi_0200 121 COG0431 COG0431, Predicted flavoprotein General function prediction only 75674350 Common lysK lysyl-tRNA synthetase Nwi_0151 77 COG1384 LysS, Lysyl-tRNA synthetase (class I) Translation, ribosomal structure and biogenesis 75675573 Common rpsE 30S ribosomal protein S5 Nwi_1381 248 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 75676540 Common - hypothetical protein Nwi_2355 32 COG4321 COG4321, Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis General function prediction only 75675942 Common - DSBA oxidoreductase Nwi_1750 75 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 75675091 Common - TonB-dependent receptor Nwi_0896 24 None None None 75674450 Common - Transcriptional regulatory protein, LysR family Nwi_0252 174 COG0583 LysR, Transcriptional regulator Transcription 75675482 Common - transposase IS4 family Nwi_1290 50 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676653 Common - hypothetical protein Nwi_2469 7 None None None 75676222 Common - Protein of unknown function DUF47 Nwi_2032 69 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 75676801 Common - Ubiquinol-cytochrome c reductase, iron-sulfur subunit Nwi_2617 108 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 75675824 Nonpathogen - hypothetical protein Nwi_1632 1 None None None 75675809 Common - phage terminase, small subunit, putative, P27 Nwi_1617 17 COG3747 COG3747, Phage terminase, small subunit DNA replication, recombination, and repair 75676481 Common - TonB-dependent receptor Nwi_2296 66 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 75676645 Common - hypothetical protein Nwi_2461 27 COG1873 COG1873, Uncharacterized conserved protein Function unknown 75674968 Nonpathogen - hypothetical protein Nwi_0772 1 None None None 75675740 Common - hypothetical protein Nwi_1548 17 None None None 75676586 Common - NAD-dependent epimerase/dehydratase Nwi_2401 152 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 75676866 Common - peptidase S11, D-alanyl-D-alanine carboxypeptidase 1 Nwi_2682 154 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 75676564 Nonpathogen - hypothetical protein Nwi_2379 3 None None None 75674997 Common - hypothetical protein Nwi_0801 4 None None None 75676241 Common - hypothetical protein Nwi_2052 11 None None None 75677179 Common - rhodanese-like sulfurtransferase Nwi_2998 115 COG1054 COG1054, Predicted sulfurtransferase General function prediction only 75677217 Common - peptidase C14, caspase catalytic subunit p20 Nwi_3036 15 COG4249 COG4249, Uncharacterized protein containing caspase domain General function prediction only 75674218 Common - transcriptional regulator, XRE family Nwi_0019 40 COG1396 HipB, Predicted transcriptional regulators Transcription 75677164 Nonpathogen - hypothetical protein Nwi_2983 4 None None None 75674961 Common - cytochrome C oxidase assembly protein Nwi_0765 68 COG3175 COX11, Cytochrome oxidase assembly factor Posttranslational modification, protein turnover, chaperones 75676901 Common tolB translocation protein TolB Nwi_2717 160 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 75674241 Common - 2-polyprenylphenol 6-hydroxylase Nwi_0042 185 COG0661 AarF, Predicted unusual protein kinase General function prediction only 75674412 Common - dihydroxy-acid dehydratase Nwi_0213 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 75674803 Nonpathogen - hypothetical protein Nwi_0605 3 None None None 75674339 Common - 2'-deoxycytidine 5'-triphosphate deaminase Nwi_0140 34 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 75676007 Nonpathogen - hypothetical protein Nwi_1815 2 None None None 75675773 Nonpathogen - hypothetical protein Nwi_1581 4 None None None 75675714 Common - Acriflavin resistance protein Nwi_1522 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 75676935 Common - multi-sensor diguanylate cyclase/phophodiesterase Nwi_2751 182 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 75675769 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase Nwi_1577 237 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 75677225 Common - FecR protein Nwi_3044 48 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 75675581 Common rplQ 50S ribosomal protein L17 Nwi_1389 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 75675922 Common - hypothetical protein Nwi_1730 20 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 75676072 Common - NADH dehydrogenase subunit G Nwi_1881 191 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 75675040 Common - hypothetical protein Nwi_0845 26 COG3311 AlpA, Predicted transcriptional regulator Transcription 75674743 Common - glucose-1-phosphate thymidylyltransferase, long form Nwi_0545 234 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 75675489 Common - ISBm1, transposase orfA Nwi_1297 78 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674405 Common rpsA 30S ribosomal protein S1 Nwi_0206 217 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 75675633 Common - CinA protein Nwi_1441 191 COG1546 CinA, Uncharacterized protein (competence- and mitomycin-induced) General function prediction only 75677066 Common - Transcriptional regulatory protein, MarR family Nwi_2885 51 COG1846 MarR, Transcriptional regulators Transcription 75674785 Common - hypothetical protein Nwi_0587 5 None None None 75674919 Common - hypothetical protein Nwi_0722 19 None None None 75677105 Common - transposase IS4 family Nwi_2924 50 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675813 Common - Phage protein, HK97, gp10 Nwi_1621 6 None None None 75674539 Common mepA penicillin-insensitive murein endopeptidase Nwi_0341 40 COG3770 MepA, Murein endopeptidase Cell envelope biogenesis, outer membrane 75674459 Common - hypothetical protein Nwi_0261 15 COG2253 COG2253, Uncharacterized conserved protein Function unknown 75676555 Common - ISRm2011-2 transposase protein Nwi_2370 38 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675688 Common - phage integrase Nwi_1496 96 None None None 75674854 Common - FecR protein Nwi_0657 48 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 75675874 Common ksgA dimethyladenosine transferase Nwi_1682 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 75676524 Common - ABC transporter, ATPase subunit Nwi_2339 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 75675312 Common flgH flagellar basal body L-ring protein Nwi_1119 102 COG2063 FlgH, Flagellar basal body L-ring protein Cell motility and secretion 75677029 Common - transposase Nwi_2848 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676061 Common - Protein of unknown function DUF1467 Nwi_1870 23 COG5454 COG5454, Predicted secreted protein Function unknown 75676383 Nonpathogen - hypothetical protein Nwi_2198 3 None None None 75675556 Common rplC 50S ribosomal protein L3 Nwi_1364 233 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 75674376 Common - RNA polymerase factor sigma-54 Nwi_0177 144 COG1508 RpoN, DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog Transcription 75675553 Common - elongation factor G Nwi_1361 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 75677172 Nonpathogen - hypothetical protein Nwi_2991 2 None None None 75676498 Common - cytochrome c oxidase, subunit II Nwi_2313 159 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 75676393 Nonpathogen - hypothetical protein Nwi_2208 3 None None None 75676922 Common - thiamine monophosphate synthase Nwi_2738 38 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 75676677 Common - hypothetical protein Nwi_2493 6 None None None 75676507 Common - ABC transporter, ATPase subunit Nwi_2322 249 COG4559 COG4559, ABC-type hemin transport system, ATPase component Inorganic ion transport and metabolism 75674229 Common - haem catalase/peroxidase Nwi_0030 98 COG0376 KatG, Catalase (peroxidase I) Inorganic ion transport and metabolism 75675762 Nonpathogen - hypothetical protein Nwi_1570 1 None None None 75674887 Common - coenzyme PQQ synthesis D Nwi_0690 19 None None None 75676151 Common - hypothetical protein Nwi_1960 19 None None None 75674636 Common - hypothetical protein Nwi_0438 8 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 75675802 Nonpathogen - hypothetical protein Nwi_1610 1 None None None 75676129 Common - CRISPR-associated TM1801 family protein Nwi_1938 55 COG3649 COG3649, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 75676175 Common - carboxysome shell protein CsoS2 Nwi_1985 9 None None None 75674929 Common - Protein of unknown function DUF891 Nwi_0732 25 COG4679 COG4679, Phage-related protein Function unknown 75676726 Common ileS isoleucyl-tRNA synthetase Nwi_2542 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 75675272 Common - aldehyde oxidase and xanthine dehydrogenase Nwi_1079 105 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 75675086 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Nwi_0891 224 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 75674828 Common clpS ATP-dependent Clp protease adaptor Nwi_0630 118 COG2127 COG2127, Uncharacterized conserved protein Function unknown 75676429 Nonpathogen - hypothetical protein Nwi_2244 3 None None None 75676148 Common - transcriptional regulator, XRE family Nwi_1957 48 COG2856 COG2856, Predicted Zn peptidase Amino acid transport and metabolism 75675008 Nonpathogen - hypothetical protein Nwi_0812 1 None None None 75676139 Common - acetate kinase Nwi_1948 162 COG0282 ackA, Acetate kinase Energy production and conversion 75675101 Common - exonuclease SbcD Nwi_0908 40 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 75676259 Nonpathogen - hypothetical protein Nwi_2070 2 None None None 75676519 Common - hypothetical protein Nwi_2334 9 None None None 75676319 Nonpathogen - hypothetical protein Nwi_2133 1 None None None 75675434 Common - extracellular solute-binding protein, family 1 Nwi_1241 131 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 75674582 Common - nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Nwi_0384 202 COG0388 COG0388, Predicted amidohydrolase General function prediction only 75674904 Common - ISRm2011-2 transposase protein Nwi_0707 40 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674605 Common - hypothetical protein Nwi_0407 15 None None None 75676826 Common - 6-phosphogluconate dehydrogenase-like protein Nwi_2642 141 COG1023 Gnd, Predicted 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 75676257 Common - nitrate reductase, alpha subunit Nwi_2068 105 COG5013 NarG, Nitrate reductase alpha subunit Energy production and conversion 75675025 Common - SMF protein Nwi_0829 208 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 75676764 Common - FAD linked oxidase Nwi_2580 137 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 75675255 Common - NAD-dependent DNA ligase Nwi_1062 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 75675268 Common - mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase Nwi_1075 164 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 75675865 Common - ABC transporter, ATPase subunit Nwi_1673 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 75676534 Common - HflK Nwi_2349 173 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 75675818 Common - peptidase U35, phage prohead HK97 Nwi_1626 38 COG3740 COG3740, Phage head maturation protease General function prediction only 75675508 Common rpsD 30S ribosomal protein S4 Nwi_1316 243 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 75675419 Common - hypothetical protein Nwi_1226 10 None None None 75675915 Common ribH riboflavin synthase subunit beta Nwi_1723 222 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 75674230 Common - glutathione S-transferase Nwi_0031 89 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 75676616 Common - pseudouridine synthase, RluD Nwi_2431 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 75675939 Common hppA membrane-bound proton-translocating pyrophosphatase Nwi_1747 98 COG3808 OVP1, Inorganic pyrophosphatase Energy production and conversion 75677113 Nonpathogen - carboxysome shell polypeptide, CsoS3 Nwi_2932 7 None None None 75674598 Common - BolA-like protein Nwi_0400 104 COG0271 BolA, Stress-induced morphogen (activity unknown) Signal transduction mechanisms 75676995 Common - Protein of unknown function DUF488 Nwi_2811 78 COG3189 COG3189, Uncharacterized conserved protein Function unknown 75676285 Common - type IV secretion system protein VirB4 Nwi_2097 32 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 75677118 Nonpathogen - hypothetical protein Nwi_2937 4 None None None 75675476 Common - glycine dehydrogenase Nwi_1284 172 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 75675266 Nonpathogen - Conserved hypothetical protein 374 Nwi_1073 15 COG0392 COG0392, Predicted integral membrane protein Function unknown 75674790 Common - O-succinylhomoserine (thiol)-lyase Nwi_0592 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 75675588 Common - probable ISRm2011-2 transposase protein Nwi_1396 40 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675191 Common - hypothetical protein Nwi_0998 4 None None None 75676422 Common - glutathione-dependent formaldehyde-activating, GFA Nwi_2237 69 COG3791 COG3791, Uncharacterized conserved protein Function unknown 75674587 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Nwi_0389 154 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 75676394 Common - Branched-chain amino acid ABC-type transport system permease components Nwi_2209 156 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 75675709 Common - D-fructose-6-phosphate amidotransferase Nwi_1517 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 75674562 Common - transposase Nwi_0364 14 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675019 Nonpathogen - hypothetical protein Nwi_0823 1 None None None 75674289 Common - glutathione S-transferase Nwi_0090 99 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 75674765 Common - peptidase M23B Nwi_0567 188 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 75675702 Common - extracellular solute-binding protein, family 5 Nwi_1510 167 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 75677135 Common gltD glutamate synthase subunit beta Nwi_2954 204 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 75676959 Common - 2-methylthioadenine synthetase Nwi_2775 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 75674206 Common - transposase Nwi_0007 76 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675172 Common - pirin Nwi_0979 147 COG1741 COG1741, Pirin-related protein General function prediction only 75675049 Common - hypothetical protein Nwi_0854 25 COG3843 VirD2, Type IV secretory pathway, VirD2 components (relaxase) Intracellular trafficking and secretion 75675996 Common - chromosome segregation and condensation protein ScpA Nwi_1804 125 COG1354 COG1354, Uncharacterized conserved protein Function unknown 75675978 Nonpathogen - hypothetical protein Nwi_1786 5 None None None 75676195 Common - Abortive infection protein Nwi_2005 29 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 75677299 Common - hypothetical protein Nwi_3121 10 None None None 75676686 Common - Protein of unknown function DUF152 Nwi_2502 180 COG1496 COG1496, Uncharacterized conserved protein Function unknown 75676100 Common - delta-aminolevulinic acid dehydratase Nwi_1909 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 75674612 Common - Protein of unknown function DUF214 Nwi_0414 88 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 75674859 Common - transcriptional regulator, XRE family Nwi_0662 109 COG1396 HipB, Predicted transcriptional regulators Transcription 75676308 Common - hypothetical protein Nwi_2122 19 None None None 75674940 Common - hypothetical protein Nwi_0743 100 COG1959 COG1959, Predicted transcriptional regulator Transcription 75674619 Common - succinyl-CoA ligase, alpha subunit Nwi_0421 212 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 75674593 Common - shikimate kinase Nwi_0395 198 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 75677236 Common - RNA polymerase sigma factor Nwi_3056 168 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75675462 Nonpathogen - hypothetical protein Nwi_1270 3 None None None 75676602 Common - cyclic nucleotide-binding protein Nwi_2417 164 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 75674257 Common ihfB integration host factor subunit beta Nwi_0058 205 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 75674947 Common - hypothetical protein Nwi_0751 13 None None None 75674233 Common - 3-hydroxydecanoyl-(acyl carrier protein) dehydratase Nwi_0034 81 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 75674446 Common hisD histidinol dehydrogenase Nwi_0247 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 75677199 Common - Acyl-CoA dehydrogenase Nwi_3018 170 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 75674552 Nonpathogen - hypothetical protein Nwi_0354 3 None None None 75676787 Common - DNA methylase N-4/N-6 Nwi_2603 135 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 75675562 Common rpsC 30S ribosomal protein S3 Nwi_1370 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 75676894 Common - peptidase M41, FtsH Nwi_2710 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 75676510 Common - antibiotic biosynthesis monooxygenase Nwi_2325 36 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 75675285 Nonpathogen - hypothetical protein Nwi_1092 3 None None None 75677056 Nonpathogen - hypothetical protein Nwi_2875 2 None None None 75675356 Common - peptidase U35, phage prohead HK97 Nwi_1163 41 COG3740 COG3740, Phage head maturation protease General function prediction only 75677320 Nonpathogen - hypothetical protein Nwi_3142 1 None None None 75674799 Common - Flagellar hook capping protein Nwi_0601 56 COG1843 FlgD, Flagellar hook capping protein Cell motility and secretion 75676470 Common - Transcriptional regulatory protein, TetR family Nwi_2285 67 COG1309 AcrR, Transcriptional regulator Transcription 75677074 Common - Protein of unknown function DUF938 Nwi_2893 49 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 75675469 Common - hypothetical protein Nwi_1277 2 None None None 75675068 Common - hypothetical protein Nwi_0873 4 None None None 75675606 Common - Polysaccharide export protein Nwi_1414 103 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 75674392 Common rph ribonuclease PH Nwi_0193 183 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 75674724 Common fliI flagellum-specific ATP synthase Nwi_0526 247 COG1157 FliI, Flagellar biosynthesis/type III secretory pathway ATPase Cell motility and secretion / Intracellular trafficking and secretion 75676479 Common - TonB-dependent siderophore receptor Nwi_2294 85 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 75674496 Common - type II secretion system protein E Nwi_0298 159 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 75675520 Common - nitrogen-fixing NifU-like Nwi_1328 69 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 75676792 Common - Chromosome segregation protein SMC Nwi_2608 177 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 75675383 Nonpathogen - hypothetical protein Nwi_1190 5 None None None 75675213 Nonpathogen - hypothetical protein Nwi_1020 1 None None None 75676736 Common - phosphoribosylamine--glycine ligase Nwi_2552 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 75675257 Common - ABC transporter, transmembrane region Nwi_1064 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 75674524 Common - glycosyl transferase, group 1 Nwi_0326 145 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 75675829 Nonpathogen - hypothetical protein Nwi_1637 1 None None None 75674262 Common - Amine oxidase Nwi_0063 32 COG1231 COG1231, Monoamine oxidase Amino acid transport and metabolism 75675678 Common - RecA-family ATPase Nwi_1486 15 COG3598 RepA, RecA-family ATPase DNA replication, recombination, and repair 75675880 Common - 3-oxoacyl-(acyl-carrier-protein) reductase Nwi_1688 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 75676051 Common dnaE DNA polymerase III subunit alpha Nwi_1860 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 75676957 Common - RNA polymerase sigma factor Nwi_2773 171 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75675039 Common - hypothetical protein Nwi_0844 13 None None None 75675031 Common - GCN5-related N-acetyltransferase Nwi_0836 46 COG3153 COG3153, Predicted acetyltransferase General function prediction only 75676903 Common - Biopolymer transport protein ExbD/TolR Nwi_2719 138 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 75676158 Common - transposase Nwi_1967 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675333 Common - phage integrase Nwi_1140 3 None None None 75674383 Common - Protein of unknown function DUF81 Nwi_0184 48 COG0730 COG0730, Predicted permeases General function prediction only 75675472 Common recA recombinase A Nwi_1280 243 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 75675894 Common - pantoate-beta-alanine ligase Nwi_1702 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 75677051 Nonpathogen - hypothetical protein Nwi_2870 6 None None None 75677222 Nonpathogen - hypothetical protein Nwi_3041 1 None None None 75676196 Common - acyl-CoA dehydrogenase Nwi_2006 149 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 75674444 Nonpathogen - hypothetical protein Nwi_0245 1 None None None 75674674 Common - Protein of unknown function DUF1332 Nwi_0476 37 COG4103 COG4103, Uncharacterized protein conserved in bacteria Function unknown 75677292 Nonpathogen - hypothetical protein Nwi_3114 1 None None None 75674487 Common - extracellular solute-binding protein, family 5 Nwi_0289 113 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 75674895 Common - aminotransferase class-III Nwi_0698 232 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 75675601 Common - Transcriptional regulatory protein, MerR family Nwi_1409 90 COG0789 SoxR, Predicted transcriptional regulators Transcription 75674833 Common - histone deacetylase superfamily Nwi_0635 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 75674291 Nonpathogen - hypothetical protein Nwi_0092 4 COG5468 COG5468, Predicted secreted (periplasmic) protein Function unknown 75676316 Common - hypothetical protein Nwi_2130 21 None None None 75677258 Common - Fec I like protein Nwi_3079 108 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75676033 Common - ComEC/Rec2-related protein Nwi_1842 106 COG0658 ComEC, Predicted membrane metal-binding protein General function prediction only 75676874 Common - Protein of unknown function DUF1013 Nwi_2690 41 COG3820 COG3820, Uncharacterized protein conserved in bacteria Function unknown 75674683 Common - GCN5-related N-acetyltransferase Nwi_0485 30 COG0456 RimI, Acetyltransferases General function prediction only 75674538 Common - molybdenum ABC transporter, periplasmic binding protein Nwi_0340 150 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 75674654 Common - Binding-protein-dependent transport systems inner membrane component Nwi_0456 177 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 75676770 Common glyS glycyl-tRNA synthetase subunit beta Nwi_2586 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 75676875 Nonpathogen - hypothetical protein Nwi_2691 3 None None None 75676462 Common - amidase Nwi_2277 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 75674436 Common - F0F1 ATP synthase subunit C Nwi_0237 7 None None None 75676097 Common - antibiotic biosynthesis monooxygenase Nwi_1906 32 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 75675346 Nonpathogen - Flp/Fap pilin component Nwi_1153 1 COG3847 Flp, Flp pilus assembly protein, pilin Flp Intracellular trafficking and secretion 75676595 Common - O-antigen polymerase Nwi_2410 6 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 75676694 Common - translation-associated GTPase Nwi_2510 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 75674922 Common - TonB-dependent receptor protein Nwi_0725 120 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 75677032 Common - conserved hypothetical/unknown protein Nwi_2851 26 COG3843 VirD2, Type IV secretory pathway, VirD2 components (relaxase) Intracellular trafficking and secretion 75675129 Nonpathogen - hypothetical protein Nwi_0936 5 None None None 75676090 Common - peptidase S14, ClpP Nwi_1899 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 75675344 Common - hypothetical protein Nwi_1151 74 COG2983 COG2983, Uncharacterized conserved protein Function unknown 75676028 Common trpD anthranilate phosphoribosyltransferase Nwi_1837 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 75677014 Common - hypothetical protein Nwi_2830 3 None None None 75675886 Common rplI 50S ribosomal protein L9 Nwi_1694 215 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 75677043 Common - transposase Nwi_2862 76 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675543 Common - DNA-directed RNA polymerase subunit beta' Nwi_1351 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 75676320 Common - Protein of unknown function DUF736 Nwi_2134 27 COG5489 COG5489, Uncharacterized conserved protein Function unknown 75676386 Common - Protein of unknown function DUF182 Nwi_2201 110 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 75675443 Nonpathogen - hypothetical protein Nwi_1251 10 None None None 75674987 Common - hypothetical protein Nwi_0791 25 None None None 75676517 Common - transposase Nwi_2332 10 None None None 75674600 Nonpathogen - hypothetical protein Nwi_0402 7 None None None 75676418 Common - dihydropteroate synthase Nwi_2233 216 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 75675731 Nonpathogen - hypothetical protein Nwi_1539 1 None None None 75674937 Common - hypothetical protein Nwi_0740 9 None None None 75676828 Common - 6-phosphogluconolactonase Nwi_2644 123 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 75677247 Common - succinyl-diaminopimelate desuccinylase Nwi_3068 202 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 75675054 Common - hypothetical protein Nwi_0859 22 COG3504 VirB9, Type IV secretory pathway, VirB9 components Intracellular trafficking and secretion 75675643 Common - aldehyde dehydrogenase Nwi_1451 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 75674883 Common - flavin reductase-like, FMN-binding Nwi_0686 116 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 75677276 Nonpathogen - hypothetical protein Nwi_3098 3 None None None 75676180 Common - hypothetical protein Nwi_1990 40 COG3002 COG3002, Uncharacterized protein conserved in bacteria Function unknown 75674429 Common - peptidase M16 Nwi_0230 201 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 75677198 Common - ErfK/YbiS/YcfS/YnhG Nwi_3017 86 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 75675623 Common - response regulator receiver Nwi_1431 224 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 75674607 Common - helicase Nwi_0409 65 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 75676331 Common - inositol-5-monophosphate dehydrogenase Nwi_2146 235 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 75675868 Common - leucyl aminopeptidase Nwi_1676 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 75676213 Common - hypothetical protein Nwi_2023 21 None None None 75676001 Common - HesB/YadR/YfhF Nwi_1809 166 COG0316 IscA, Uncharacterized conserved protein Function unknown 75674401 Common - phosphoglyceromutase Nwi_0202 176 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 75676347 Common - hypothetical protein Nwi_2162 8 None None None 75677204 Common - cytochrome c oxidoreductase subunit B Nwi_3023 13 None None None 75676800 Common - cytochrome c1 Nwi_2616 149 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 75675853 Common - cysteine desulphurases, SufS Nwi_1661 239 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 75675161 Common - tyrosinase Nwi_0968 18 None None None 75675604 Common - sugar transferase Nwi_1412 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 75675879 Common acpP acyl carrier protein Nwi_1687 209 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 75676235 Common - transposase IS3/IS911 Nwi_2046 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75677311 Common - Transcriptional regulatory protein, MerR family Nwi_3133 146 COG0789 SoxR, Predicted transcriptional regulators Transcription 75674659 Common - hypothetical protein Nwi_0461 81 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 75675232 Nonpathogen - hypothetical protein Nwi_1039 1 None None None 75676080 Nonpathogen - hypothetical protein Nwi_1889 3 None None None 75676545 Common - UvrD/REP helicase Nwi_2360 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 75674277 Common - acyl-CoA thioesterase Nwi_0078 77 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 75674361 Common - Multi antimicrobial extrusion protein MatE Nwi_0162 131 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 75675450 Nonpathogen - hypothetical protein Nwi_1258 11 None None None 75674565 Common recR recombination protein RecR Nwi_0367 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 75676684 Nonpathogen - hypothetical protein Nwi_2500 3 None None None 75676579 Common - Nucleotidyl transferase Nwi_2394 218 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 75676038 Common - Protein of unknown function DUF1009 Nwi_1847 45 COG3494 COG3494, Uncharacterized protein conserved in bacteria Function unknown 75675661 Nonpathogen - hypothetical protein Nwi_1469 3 None None None 75674865 Common - ABC-type branched-chain amino acid transport systems ATPase component Nwi_0668 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 75676112 Common - pyridoxal phosphate biosynthetic protein PdxJ Nwi_1921 139 COG0854 PdxJ, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 75676432 Nonpathogen - hypothetical protein Nwi_2247 3 None None None 75676841 Common - putative monovalent cation/H+ antiporter subunit E Nwi_2657 58 COG1863 MnhE, Multisubunit Na+/H+ antiporter, MnhE subunit Inorganic ion transport and metabolism 75676364 Nonpathogen - hypothetical protein Nwi_2179 4 None None None 75675530 Common - TonB-dependent siderophore receptor Nwi_1338 112 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 75674810 Nonpathogen - hypothetical protein Nwi_0612 1 None None None 75676742 Common - hypothetical protein Nwi_2558 24 None None None 75675411 Common - tripartite ATP-independent periplasmic transporter, DctQ component Nwi_1218 76 COG4665 FcbT2, TRAP-type mannitol/chloroaromatic compound transport system, small permease component Secondary metabolites biosynthesis, transport, and catabolism 75674716 Common - inositol monophosphatase Nwi_0518 189 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 75675901 Common - transcriptional regulator, XRE family Nwi_1709 37 COG2944 COG2944, Predicted transcriptional regulator Transcription 75676996 Common - heat shock protein 90 Nwi_2812 150 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 75674585 Common - NUDIX hydrolase Nwi_0387 110 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 75675728 Nonpathogen - hypothetical protein Nwi_1536 1 None None None 75677121 Common - Heat shock protein Hsp20 Nwi_2940 163 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 75674319 Common - pantothenate kinase Nwi_0120 81 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 75674748 Common - hypothetical protein Nwi_0550 5 None None None 75674573 Common - hypothetical protein Nwi_0375 31 None None None 75676936 Common - hypothetical protein Nwi_2752 130 COG1678 COG1678, Putative transcriptional regulator Transcription 75674735 Common - sel1-like repeat protein Nwi_0537 110 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 75674211 Common - Ribosomal-protein-alanine acetyltransferase Nwi_0012 183 COG0456 RimI, Acetyltransferases General function prediction only 75676377 Common groEL chaperonin GroEL Nwi_2192 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 75674528 Common - creatininase Nwi_0330 86 COG1402 COG1402, Uncharacterized protein, putative amidase General function prediction only 75675598 Common - fatty acid/phospholipid synthesis protein Nwi_1406 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 75675197 Common - Protein of unknown function DUF465 Nwi_1004 17 COG5570 COG5570, Uncharacterized small protein Function unknown 75674623 Common - dihydrolipoamide dehydrogenase Nwi_0425 244 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 75675119 Common - peptidase M3A and M3B, thimet/oligopeptidase F Nwi_0926 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 75675656 Common - thymidylate kinase Nwi_1464 226 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 75675635 Common - dihydrouridine synthase TIM-barrel protein nifR3 Nwi_1443 206 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 75675247 Common murB UDP-N-acetylenolpyruvoylglucosamine reductase Nwi_1054 193 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 75674442 Common - biotin synthase Nwi_0243 174 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 75675591 Common - hypothetical protein Nwi_1399 5 None None None 75675442 Common - resolvase Nwi_1250 84 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 75675760 Common uvrA excinuclease ABC subunit A Nwi_1568 242 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 75675309 Common - Heat shock protein Hsp20 Nwi_1116 66 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 75675833 Common - Protein of unknown function DUF160 Nwi_1641 125 COG1509 KamA, Lysine 2,3-aminomutase Amino acid transport and metabolism 75675115 Common - transcription elongation factor GreA/GreB region Nwi_0922 81 COG0782 GreA, Transcription elongation factor Transcription 75676638 Common - Transcriptional regulatory protein, LysR family Nwi_2454 188 COG0583 LysR, Transcriptional regulator Transcription 75674758 Common - cyclic nucleotide-binding Nwi_0560 12 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 75675375 Common - hypothetical protein Nwi_1182 25 None None None 75674927 Common - type IV secretory pathway VirD4 components Nwi_0730 8 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 75675745 Common - hypothetical protein Nwi_1553 6 None None None 75677000 Common - ApbE-like lipoprotein Nwi_2816 135 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 75675568 Common rplE 50S ribosomal protein L5 Nwi_1376 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 75676143 Common - hypothetical protein Nwi_1952 20 None None None 75675628 Common valS valyl-tRNA synthetase Nwi_1436 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 75676739 Common - tetraacyldisaccharide-1-P 4'-kinase Nwi_2555 130 COG1663 LpxK, Tetraacyldisaccharide-1-P 4'-kinase Cell envelope biogenesis, outer membrane 75676818 Common - metallophosphoesterase Nwi_2634 45 COG1409 Icc, Predicted phosphohydrolases General function prediction only 75674957 Common - cytochrome c oxidase, subunit II Nwi_0761 141 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 75676889 Common - DNA-3-methyladenine glycosylase I Nwi_2705 132 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 75676017 Nonpathogen - outer membrane protein Nwi_1826 4 COG4625 COG4625, Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain Function unknown 75676833 Common - cytochrome c, class IC Nwi_2649 6 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 75674556 Common - acyltransferase 3 Nwi_0358 24 COG4763 COG4763, Predicted membrane protein Function unknown 75674269 Common - hypothetical protein Nwi_0070 38 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 75676423 Common - methylmalonyl-CoA mutase Nwi_2238 111 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 75675725 Common - glycosyl transferase, family 39 Nwi_1533 77 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 75674638 Common rpmA 50S ribosomal protein L27 Nwi_0440 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 75676983 Common - succinate dehydrogenase, cytochrome b subunit Nwi_2799 35 COG2142 SdhD, Succinate dehydrogenase, hydrophobic anchor subunit Energy production and conversion 75676819 Common - Protein of unknown function DUF486 Nwi_2635 53 COG3169 COG3169, Uncharacterized protein conserved in bacteria Function unknown 75675120 Common - hypothetical protein Nwi_0927 21 COG3686 COG3686, Predicted membrane protein Function unknown 75675493 Nonpathogen - hypothetical protein Nwi_1301 2 None None None 75675300 Nonpathogen - hypothetical protein Nwi_1107 3 None None None 75675368 Common - gene transfer agent (GTA) like protein Nwi_1175 12 None None None 75677064 Common - Fec I like protein Nwi_2883 86 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75676863 Common - DedA Nwi_2679 56 COG1238 COG1238, Predicted membrane protein Function unknown 75676044 Common - 1-deoxy-D-xylulose 5-phosphate reductoisomerase Nwi_1853 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 75674480 Common - Transcriptional regulator Nwi_0282 86 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 75676268 Common - hypothetical protein Nwi_2079 56 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 75675404 Common - Conserved hypothetical protein 2281, catalytic Nwi_1211 33 COG3577 COG3577, Predicted aspartyl protease General function prediction only 75677308 Common - Secretion protein HlyD Nwi_3130 153 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 75676730 Common - peptidase M16 Nwi_2546 176 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 75676941 Common - sulphate transport system permease protein 1 Nwi_2757 249 COG1118 CysA, ABC-type sulfate/molybdate transport systems, ATPase component Inorganic ion transport and metabolism 75675099 Common - cupin region Nwi_0906 25 COG4101 COG4101, Predicted mannose-6-phosphate isomerase Carbohydrate transport and metabolism 75676971 Nonpathogen - hypothetical protein Nwi_2787 2 None None None 75677189 Common - probable ISRm2011-2 transposase protein Nwi_3008 40 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675751 Nonpathogen - hypothetical protein Nwi_1559 1 None None None 75674356 Common - heparinase II/III-like Nwi_0157 42 COG5360 COG5360, Uncharacterized protein conserved in bacteria Function unknown 75676897 Common - TPR repeat protein Nwi_2713 74 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 75676769 Nonpathogen - Protein of unknown function DUF1236 Nwi_2585 7 None None None 75676666 Common - hypothetical protein Nwi_2482 162 COG0628 PerM, Predicted permease General function prediction only 75677281 Nonpathogen - hypothetical protein Nwi_3103 3 None None None 75676473 Common - beta-lactamase Nwi_2288 126 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 75677288 Common - hypothetical protein Nwi_3110 28 COG4680 COG4680, Uncharacterized protein conserved in bacteria Function unknown 75674706 Common - phosphate transport system permease protein 2 Nwi_0508 222 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 75675648 Common - Secretion protein HlyD Nwi_1456 141 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 75677182 Common - 2-nitropropane dioxygenase, NPD Nwi_3001 144 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 75674912 Common - argininosuccinate lyase Nwi_0715 228 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 75674770 Common - methylated-DNA-(protein)-cysteine S-methyltransferase Nwi_0572 150 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 75675929 Nonpathogen - hypothetical protein Nwi_1737 4 None None None 75674201 Common - DNA polymerase III subunit beta Nwi_0002 216 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 75675699 Common - 2-octaprenyl-6-methoxyphenyl hydroxylase Nwi_1507 121 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 75676718 Common - Protein of unknown function DUF559 Nwi_2534 46 COG2852 COG2852, Uncharacterized protein conserved in bacteria Function unknown 75676570 Common - GDP-mannose 4,6-dehydratase Nwi_2385 221 COG1089 Gmd, GDP-D-mannose dehydratase Cell envelope biogenesis, outer membrane 75676526 Common - ketol-acid reductoisomerase Nwi_2341 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 75677152 Common - hypothetical protein Nwi_2971 20 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 75676840 Common - putative monovalent cation/H+ antiporter subunit D Nwi_2656 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 162139847 Common rplJ 50S ribosomal protein L10 Nwi_1348 211 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 75675186 Common - peptidase M3B, oligoendopeptidase-related clade 3 Nwi_0993 89 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 75674226 Common rpsO 30S ribosomal protein S15 Nwi_0027 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 75676352 Common - adenylosuccinate lyase Nwi_2167 236 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 75674642 Common - gamma-glutamyl phosphate reductase GPR Nwi_0444 187 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 75675017 Nonpathogen - hypothetical protein Nwi_0821 1 None None None 75675980 Nonpathogen - hypothetical protein Nwi_1788 5 None None None 75676110 Common - peptidase S26A, signal peptidase I Nwi_1919 207 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 75676183 Nonpathogen - hypothetical protein Nwi_1993 4 None None None 75675914 Common nusB transcription antitermination protein NusB Nwi_1722 120 COG0781 NusB, Transcription termination factor Transcription 75675156 Common - type I secretion membrane fusion protein, HlyD Nwi_0963 115 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 75675010 Nonpathogen - hypothetical protein Nwi_0814 1 None None None 75676346 Common - Nuclear protein SET Nwi_2161 24 COG2940 COG2940, Proteins containing SET domain General function prediction only 75676255 Nonpathogen - hypothetical protein Nwi_2066 1 None None None 75674290 Common leuS leucyl-tRNA synthetase Nwi_0091 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 75676913 Common - hypothetical protein Nwi_2729 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 75675164 Common - methionine sulfoxide reductase A Nwi_0971 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 75674783 Common metX homoserine O-acetyltransferase Nwi_0585 133 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 75675074 Common - TonB-dependent receptor Nwi_0879 78 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 75676924 Common - inositol monophosphatase Nwi_2740 210 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 75676127 Common - Protein of unknown function DUF48 Nwi_1936 101 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 75675522 Common hisI phosphoribosyl-AMP cyclohydrolase Nwi_1330 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 75674857 Common - helix-turn-helix, Fis-type Nwi_0660 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676484 Common - hypothetical protein Nwi_2299 5 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 75676685 Common - ribose-phosphate pyrophosphokinase Nwi_2501 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 75675066 Common - transposase IS3/IS911 Nwi_0871 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675775 Common - CreA Nwi_1583 57 COG3045 CreA, Uncharacterized protein conserved in bacteria Function unknown 75677246 Common - 5'-methylthioadenosine nucleosidase / S-adenosylhomocysteine nucleosidase Nwi_3067 26 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 75675544 Nonpathogen - hypothetical protein Nwi_1352 5 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 75676713 Common - ribonuclease T2 Nwi_2529 50 COG3719 Rna, Ribonuclease I Translation, ribosomal structure and biogenesis 75676248 Common - transposase Nwi_2059 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675790 Common - phosphoribosylglycinamide formyltransferase Nwi_1598 220 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 75674614 Common - Lysophospholipase L1 and related esterase Nwi_0416 95 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 75675501 Common - BolA-like protein Nwi_1309 86 COG0271 BolA, Stress-induced morphogen (activity unknown) Signal transduction mechanisms 75676391 Common - carbon monoxide dehydrogenase subunit G Nwi_2206 42 COG3427 COG3427, Uncharacterized conserved protein Function unknown 75675991 Common coaD phosphopantetheine adenylyltransferase Nwi_1799 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 75674497 Common - pilus assembly protein cpaE Nwi_0299 40 COG4963 CpaE, Flp pilus assembly protein, ATPase CpaE Intracellular trafficking and secretion 75675671 Common - hypothetical protein Nwi_1479 3 None None None 75676600 Nonpathogen - hypothetical protein Nwi_2415 1 None None None 75677230 Common - ABC-type Fe3+-hydroxamate transport system periplasmic component Nwi_3050 22 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 75675089 Common - Sigma 24, ECF subfamily Nwi_0894 72 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75676731 Common - hypothetical protein Nwi_2547 113 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 75675479 Common alaS alanyl-tRNA synthetase Nwi_1287 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 75674610 Common - transcription factor CarD Nwi_0412 83 COG1329 COG1329, Transcriptional regulators, similar to M. xanthus CarD Transcription 75675764 Common - integrase, catalytic region Nwi_1572 141 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674490 Common - ABC transporter, ATPase subunit Nwi_0292 249 COG4172 COG4172, ABC-type uncharacterized transport system, duplicated ATPase component General function prediction only 75676413 Common - hypothetical protein Nwi_2228 8 None None None 75676532 Nonpathogen - hypothetical protein Nwi_2347 3 COG3242 COG3242, Uncharacterized protein conserved in bacteria Function unknown 75677072 Common - ErfK/YbiS/YcfS/YnhG Nwi_2891 86 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 75674825 Common - Transcriptional regulatory protein, LuxR family Nwi_0627 62 COG2771 CsgD, DNA-binding HTH domain-containing proteins Transcription 75675783 Common - transposase Nwi_1591 76 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675103 Common - Protein of unknown function DUF156 Nwi_0910 100 COG1937 COG1937, Uncharacterized protein conserved in bacteria Function unknown 75674384 Common - Conserved hypothetical protein 2186 Nwi_0185 28 None None None 75676790 Common - Protein of unknown function DUF1159 Nwi_2606 29 COG5389 COG5389, Uncharacterized protein conserved in bacteria Function unknown 75677059 Nonpathogen - hypothetical protein Nwi_2878 1 None None None 75675800 Common - Protein of unknown function DUF192 Nwi_1608 86 COG1430 COG1430, Uncharacterized conserved protein Function unknown 75676342 Common - enoyl-CoA hydratase Nwi_2157 159 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 75675435 Common - lipid A biosynthesis lauroyl acyltransferase Nwi_1242 80 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 75674250 Common - thioredoxin Nwi_0051 234 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 75677093 Common - Secretion protein HlyD Nwi_2912 170 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 75676313 Common - hypothetical protein Nwi_2127 9 None None None 75675292 Common - Flagellar basal body rod protein, FlaE Nwi_1099 126 COG1749 FlgE, Flagellar hook protein FlgE Cell motility and secretion 75676998 Common - hypothetical protein Nwi_2814 26 COG3656 COG3656, Predicted periplasmic protein Function unknown 75674842 Common - acylneuraminate cytidylyltransferase Nwi_0645 28 COG1861 SpsF, Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog Cell envelope biogenesis, outer membrane 75676612 Nonpathogen - hypothetical protein Nwi_2427 1 None None None 75675993 Common - DNA gyrase subunit A Nwi_1801 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 75675535 Common - PRC-barrel protein Nwi_1343 31 None None None 75675001 Nonpathogen - hypothetical protein Nwi_0805 1 None None None 75674235 Common - Protein of unknown function DUF1058 Nwi_0036 45 COG3807 COG3807, Uncharacterized protein conserved in bacteria Function unknown 75676781 Nonpathogen - hypothetical protein Nwi_2597 6 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 75677208 Common - Major facilitator superfamily MFS_1 Nwi_3027 139 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 75674557 Common - ATP-dependent helicase HrpB Nwi_0359 131 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 75674737 Common - glycosyl transferase, family 2 Nwi_0539 147 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 75676088 Common - peptidase S16, ATP-dependent protease La Nwi_1897 227 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 75674751 Common - HAD-superfamily hydrolase subfamily IA, variant 3 Nwi_0553 133 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 75677123 Common - transposase IS3/IS911 Nwi_2942 33 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674478 Nonpathogen - hypothetical protein Nwi_0280 1 None None None 75676850 Common - transposase IS3/IS911 Nwi_2666 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75677120 Common - Heat shock protein Hsp20 Nwi_2939 65 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 75674817 Common - ErfK/YbiS/YcfS/YnhG Nwi_0619 84 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 75676287 Common - helix-turn-helix, Fis-type Nwi_2099 119 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674298 Common - Protein of unknown function DUF255 Nwi_0099 105 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 75676280 Common - Conjugal transfer protein TrbG/VirB9/CagX Nwi_2092 53 COG3504 VirB9, Type IV secretory pathway, VirB9 components Intracellular trafficking and secretion 75674866 Common - ABC-type branched-chain amino acid transport systems ATPase component Nwi_0669 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 75675683 Common - transposase IS3/IS911 Nwi_1491 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674942 Common - HNH endonuclease Nwi_0745 96 COG1403 McrA, Restriction endonuclease Defense mechanisms 75674287 Common - hypothetical protein Nwi_0088 45 COG3786 COG3786, Uncharacterized protein conserved in bacteria Function unknown 75674236 Common - 2-hydroxyacid dehydrogenase Nwi_0037 230 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 75676748 Common - Conserved hypothetical protein 46 Nwi_2564 142 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 75676821 Nonpathogen - hypothetical protein Nwi_2637 1 None None None 75675405 Common - Signal transduction histidine kinase Nwi_1212 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 75674216 Common - CTransporter-associated region Nwi_0017 216 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 75675252 Common lpxC UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase Nwi_1059 139 COG0774 LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase Cell envelope biogenesis, outer membrane 75674465 Common - hypothetical protein Nwi_0267 17 COG4694 COG4694, Uncharacterized protein conserved in bacteria Function unknown 75677133 Common - Heat shock protein Hsp20 Nwi_2952 70 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 75674847 Common - hypothetical protein Nwi_0650 5 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 75674202 Common recF recombination protein F Nwi_0003 124 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 75675174 Nonpathogen - hypothetical protein Nwi_0981 4 None None None 75675629 Common - major facilitator superfamily MFS_1 Nwi_1437 9 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 75674792 Common - exodeoxyribonuclease V Nwi_0594 97 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 162139839 Common - putative transposase Nwi_3087 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674805 Common - 3,4-Dihydroxy-2-butanone 4-phosphate synthase Nwi_0607 228 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 75674795 Common fliH flagellar assembly protein H Nwi_0597 11 COG1317 FliH, Flagellar biosynthesis/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 75674352 Common pyrE orotate phosphoribosyltransferase Nwi_0153 90 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 75675852 Common - Protein of unknown function DUF59 Nwi_1660 130 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 75675605 Common - glycosyl transferase, group 1 Nwi_1413 201 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 75676011 Common - septum formation initiator Nwi_1819 25 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 75674374 Nonpathogen - hypothetical protein Nwi_0175 1 None None None 75676630 Common - carbamoyl phosphate synthase small subunit Nwi_2446 234 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 75676296 Nonpathogen - hypothetical protein Nwi_2110 1 None None None 75674403 Common - hypothetical protein Nwi_0204 25 COG5488 COG5488, Integral membrane protein Function unknown 75674988 Common - gene transfer agent (GTA) like protein Nwi_0792 27 None None None 75675499 Common - hypothetical protein Nwi_1307 4 None None None 75674663 Common - Protein of unknown function DUF952 Nwi_0465 45 COG3502 COG3502, Uncharacterized protein conserved in bacteria Function unknown 75676278 Common - hypothetical protein Nwi_2090 23 COG5639 COG5639, Uncharacterized conserved small protein Function unknown 75676067 Common - NADH dehydrogenase subunit L Nwi_1876 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 75676561 Nonpathogen - hypothetical protein Nwi_2376 1 None None None 75674242 Common - bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase Nwi_0043 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 75675558 Common rplW 50S ribosomal protein L23 Nwi_1366 229 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 75674259 Common - CysZ-like protein Nwi_0060 28 COG2981 CysZ, Uncharacterized protein involved in cysteine biosynthesis Amino acid transport and metabolism 75676862 Nonpathogen - hypothetical protein Nwi_2678 1 None None None 75675354 Common - Phage portal protein, HK97 Nwi_1161 65 COG4695 COG4695, Phage-related protein Function unknown 75677161 Common - aspartate aminotransferase Nwi_2980 236 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 75675719 Common - amino acid ABC transporter, inner membrane component Nwi_1527 171 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 75675952 Common - NADH dehydrogenase Nwi_1760 38 COG3761 COG3761, NADH:ubiquinone oxidoreductase 17.2 kD subunit Energy production and conversion 75675043 Common - hypothetical protein Nwi_0848 22 None None None 75674917 Common - rieske (2Fe-2S) region Nwi_0720 82 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 75677027 Common - peptidase C14, caspase catalytic subunit p20 Nwi_2846 19 COG4249 COG4249, Uncharacterized protein containing caspase domain General function prediction only 75676937 Common - hypothetical protein Nwi_2753 59 COG4233 COG4233, Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis Posttranslational modification, protein turnover, chaperones / Energy production and conversion 75676354 Common - phosphate-selective porin O and P Nwi_2169 11 COG3746 OprP, Phosphate-selective porin Inorganic ion transport and metabolism 75676125 Common - transposase, IS4 Nwi_1934 62 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676851 Common - hypothetical protein Nwi_2667 13 None None None 75674334 Common apaG ApaG Nwi_0135 89 COG2967 ApaG, Uncharacterized protein affecting Mg2+/Co2+ transport Inorganic ion transport and metabolism 75675327 Nonpathogen fliE flagellar hook-basal body protein FliE Nwi_1134 7 COG1677 FliE, Flagellar hook-basal body protein Cell motility and secretion / Intracellular trafficking and secretion 75675971 Common tatA twin argininte translocase protein A Nwi_1779 93 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 75675822 Nonpathogen - hypothetical protein Nwi_1630 1 None None None 75675283 Nonpathogen - hypothetical protein Nwi_1090 4 None None None 75675845 Common - DNA topoisomerase IV subunit B Nwi_1653 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 75675385 Common - cytochrome c-type biogenesis protein CcmE Nwi_1192 95 COG2332 CcmE, Cytochrome c-type biogenesis protein CcmE Posttranslational modification, protein turnover, chaperones 75675620 Common - hypothetical protein Nwi_1428 19 None None None 75676509 Common - periplasmic binding protein Nwi_2324 75 COG4558 ChuT, ABC-type hemin transport system, periplasmic component Inorganic ion transport and metabolism 75676449 Common - hypothetical protein Nwi_2264 18 COG4731 COG4731, Uncharacterized protein conserved in bacteria Function unknown 75674809 Common - ABC transporter, transmembrane region Nwi_0611 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 75675271 Common - virulence factor MVIN-like Nwi_1078 188 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 75676495 Common - short chain dehydrogenase Nwi_2310 167 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 75674906 Nonpathogen - hypothetical protein Nwi_0709 2 None None None 75676170 Common - Carboxysome structural peptide CsoS1B Nwi_1980 46 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 75676177 Common rbcL ribulose bisophosphate carboxylase Nwi_1987 67 COG1850 RbcL, Ribulose 1,5-bisphosphate carboxylase, large subunit Carbohydrate transport and metabolism 75677144 Nonpathogen - hypothetical protein Nwi_2963 2 None None None 75674679 Common - integrase, catalytic region Nwi_0481 62 None None None 75676023 Common - hypothetical protein Nwi_1832 5 COG4104 COG4104, Uncharacterized conserved protein Function unknown 75675578 Common rpsM 30S ribosomal protein S13 Nwi_1386 243 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 75674603 Common - hypothetical protein Nwi_0405 22 COG4246 COG4246, Uncharacterized protein conserved in bacteria Function unknown 75676628 Nonpathogen - hypothetical protein Nwi_2444 1 None None None 75676440 Common dnaE2 error-prone DNA polymerase Nwi_2255 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 75677251 Nonpathogen - Protein of unknown function DUF423 Nwi_3072 4 COG2363 COG2363, Uncharacterized small membrane protein Function unknown 75677151 Common - hypothetical protein Nwi_2970 13 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 75675712 Common - hypothetical protein Nwi_1520 32 COG3148 COG3148, Uncharacterized conserved protein Function unknown 75676617 Nonpathogen - hypothetical protein Nwi_2432 4 None None None 75676585 Common - methyltransferase FkbM Nwi_2400 14 None None None 75674651 Common - staphylococcus nuclease (SNase-like) Nwi_0453 7 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 75676221 Common - phosphate transporter Nwi_2031 166 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 75675832 Nonpathogen - hypothetical protein Nwi_1640 1 None None None 75675097 Common - hypothetical protein Nwi_0904 14 None None None 75675413 Common - phosphoglycolate phosphatase Nwi_1220 172 COG0546 Gph, Predicted phosphatases General function prediction only 75676233 Common - hypothetical protein Nwi_2043 10 None None None 75676647 Common - lytic transglycosylase, catalytic Nwi_2463 30 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 75674505 Common - Flp pilus assembly protein TadG Nwi_0307 15 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 75675927 Common - acylphosphatase Nwi_1735 129 COG1254 AcyP, Acylphosphatases Energy production and conversion 75675575 Common rplO 50S ribosomal protein L15 Nwi_1383 204 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 75674851 Common - ISRm2011-2 transposase protein Nwi_0654 40 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75677067 Common - glyoxalase/bleomycin resistance protein/dioxygenase Nwi_2886 60 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 75674712 Common - ornithine carbamoyltransferase Nwi_0514 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 75674471 Nonpathogen - hypothetical protein Nwi_0273 1 None None None 75674760 Nonpathogen - hypothetical protein Nwi_0562 3 None None None 75676571 Common - glycosyl transferase, group 1 Nwi_2386 74 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 75676103 Common - manganese transport protein MntH Nwi_1912 83 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 75674393 Common hrcA heat-inducible transcription repressor Nwi_0194 148 COG1420 HrcA, Transcriptional regulator of heat shock gene Transcription 75677020 Common - hypothetical protein Nwi_2837 4 None None None 75677178 Common - CsbD-like protein Nwi_2997 16 COG3237 COG3237, Uncharacterized protein conserved in bacteria Function unknown 75677039 Common - hypothetical protein Nwi_2858 23 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 75676751 Common - glycosyl transferase, family 2 Nwi_2567 187 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 75675084 Common - Protein of unknown function DUF442 Nwi_0889 100 COG3453 COG3453, Uncharacterized protein conserved in bacteria Function unknown 75675945 Common - acetyl-CoA carboxylase biotin carboxylase subunit Nwi_1753 232 COG0439 AccC, Biotin carboxylase Lipid metabolism 75677170 Common - hypothetical protein Nwi_2989 34 COG3812 COG3812, Uncharacterized protein conserved in bacteria Function unknown 75675264 Common - cytidyltransferase-related, RfaE bifunctional protein Nwi_1071 128 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 75677041 Common - nucleic acid binding, OB-fold, tRNA/helicase-type Nwi_2860 123 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 75677079 Common - hypothetical protein Nwi_2898 6 COG5569 COG5569, Uncharacterized conserved protein Function unknown 75675460 Common - Biopolymer transport protein ExbD/TolR Nwi_1268 104 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 75675398 Common - alpha amylase Nwi_1205 166 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 75676640 Nonpathogen - hypothetical protein Nwi_2456 2 None None None 75674544 Common - hypothetical protein Nwi_0346 33 COG1493 HprK, Serine kinase of the HPr protein, regulates carbohydrate metabolism Signal transduction mechanisms 75675998 Common - proline-rich protein Nwi_1806 19 None None None 75674999 Nonpathogen - hypothetical protein Nwi_0803 5 None None None 75675471 Nonpathogen - hypothetical protein Nwi_1279 1 None None None 75676282 Common - TrbL/VirB6 plasmid conjugal transfer protein Nwi_2094 28 COG3846 TrbL, Type IV secretory pathway, TrbL components Intracellular trafficking and secretion 75674418 Common - pirin Nwi_0219 142 COG1741 COG1741, Pirin-related protein General function prediction only 75676513 Nonpathogen - hypothetical protein Nwi_2328 1 None None None 75675122 Common - Band 7 protein Nwi_0929 219 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 75676816 Common - GCN5-related N-acetyltransferase Nwi_2632 86 COG3153 COG3153, Predicted acetyltransferase General function prediction only 75674745 Common - dTDP-4-dehydrorhamnose reductase Nwi_0547 168 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 75675959 Common - Protein of unknown function DUF598 Nwi_1767 42 COG3737 COG3737, Uncharacterized conserved protein Function unknown 75676471 Common - Glu/Leu/Phe/Val dehydrogenase Nwi_2286 176 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 75675136 Common - di-haem cytochrome c peroxidase Nwi_0943 95 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 75676476 Nonpathogen - hypothetical protein Nwi_2291 1 None None None 75674692 Common ispG 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase Nwi_0494 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 75677085 Common - possible signal peptide protein Nwi_2904 25 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 75674482 Common - 5,10-methylenetetrahydrofolate reductase Nwi_0284 148 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 75675109 Common - Periplasmic solute binding protein Nwi_0916 153 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 75677283 Common - transposase IS3/IS911 Nwi_3105 33 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674888 Common - pyrroloquinoline quinone biosynthesis protein PqqC Nwi_0691 34 COG5424 COG5424, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C Coenzyme metabolism 75675424 Common - putative alpha-isopropylmalate/homocitrate synthase family transferase Nwi_1231 211 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 75675781 Common - ribonuclease D Nwi_1589 123 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 75676137 Common - probable transmembrane protein Nwi_1946 7 None None None 75675420 Nonpathogen - hypothetical protein Nwi_1227 5 None None None 75676848 Common - Protein of unknown function DUF892 Nwi_2664 37 COG3685 COG3685, Uncharacterized protein conserved in bacteria Function unknown 75674358 Common - cytochrome c, class I Nwi_0159 63 COG2863 COG2863, Cytochrome c553 Energy production and conversion 75676223 Common - Conserved hypothetical protein ArsC related Nwi_2033 108 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 75674632 Common - H+-transporting two-sector ATPase, delta/epsilon subunit Nwi_0434 178 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 75675753 Nonpathogen - hypothetical protein Nwi_1561 1 None None None 75675445 Common - Type I restriction enzyme EcoAI specificity protein Nwi_1253 53 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 75675225 Nonpathogen - ABC transporter substrate-binding protein Nwi_1032 6 COG3218 COG3218, ABC-type uncharacterized transport system, auxiliary component General function prediction only 75676021 Common - major facilitator superfamily MFS_1 Nwi_1830 153 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 75675693 Common - hypothetical protein Nwi_1501 101 COG2049 DUR1, Allophanate hydrolase subunit 1 Amino acid transport and metabolism 75674710 Common - GcrA cell cycle regulator Nwi_0512 33 COG5352 COG5352, Uncharacterized protein conserved in bacteria Function unknown 75674757 Common - HWE histidine kinase Nwi_0559 34 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 75677009 Common - hypothetical protein Nwi_2825 4 None None None 75674971 Nonpathogen - hypothetical protein Nwi_0775 1 None None None 75677157 Common - FeoA Nwi_2976 15 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 75677313 Nonpathogen - phage integrase Nwi_3135 3 None None None 75676073 Common - NADH-quinone oxidoreductase, F subunit Nwi_1882 166 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 75676261 Common - TonB-dependent receptor Nwi_2072 77 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 75676185 Common - hypothetical protein Nwi_1995 10 None None None 75675593 Common - carboxyl transferase Nwi_1401 207 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 75675491 Common - helix-turn-helix, Fis-type Nwi_1299 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676231 Common - ABC transporter, ATPase subunit Nwi_2041 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 75676830 Common - glycoside hydrolase 15-related protein Nwi_2646 69 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 75675627 Common - hypothetical protein Nwi_1435 25 COG3827 COG3827, Uncharacterized protein conserved in bacteria Function unknown 75674440 Common - Transcriptional regulatory protein, LuxR family Nwi_0241 220 COG4566 TtrR, Response regulator Signal transduction mechanisms 75675148 Common - hypothetical protein Nwi_0955 22 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 75677065 Nonpathogen - hypothetical protein Nwi_2884 1 None None None 75676655 Common - peptidase S9, prolyl oligopeptidase Nwi_2471 100 COG1770 PtrB, Protease II Amino acid transport and metabolism 75675908 Common - Penicillin-binding protein 1A Nwi_1716 201 COG5009 MrcA, Membrane carboxypeptidase/penicillin-binding protein Cell envelope biogenesis, outer membrane 75674625 Common - primosome assembly protein PriA Nwi_0427 211 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 75674773 Nonpathogen - hypothetical protein Nwi_0575 12 None None None 75675467 Nonpathogen - hypothetical protein Nwi_1275 3 None None None 75676899 Common - hypothetical protein Nwi_2715 8 None None None 75676717 Common hisS histidyl-tRNA synthetase Nwi_2533 247 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 75676525 Common - Substrate-binding region and inner membrane component of ABC-type glycine betaine transport system Nwi_2340 141 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 75674553 Common - hypothetical protein Nwi_0355 63 COG1273 COG1273, Uncharacterized conserved protein Function unknown 75674228 Common - regulatory protein, LysR Nwi_0029 181 COG0583 LysR, Transcriptional regulator Transcription 75676980 Common - copper/Zinc superoxide dismutase Nwi_2796 87 COG2032 SodC, Cu/Zn superoxide dismutase Inorganic ion transport and metabolism 75675192 Common rpsU 30S ribosomal protein S21 Nwi_0999 38 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 75677160 Common - Protein of unknown function DUF992 Nwi_2979 11 None None None 75676204 Common - alanine racemase region Nwi_2014 199 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 75677130 Common - probable ISRm2011-2 transposase protein Nwi_2949 40 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675302 Nonpathogen - hypothetical protein Nwi_1109 5 None None None 75676141 Common - putative phage-related protein Nwi_1950 17 None None None 75674347 Nonpathogen - hypothetical protein Nwi_0148 1 None None None 75675532 Common - Fec I like protein Nwi_1340 31 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75675619 Common - endoribonuclease L-PSP Nwi_1427 101 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 75674328 Common hslU ATP-dependent protease ATP-binding subunit Nwi_0129 210 COG1220 HslU, ATP-dependent protease HslVU (ClpYQ), ATPase subunit Posttranslational modification, protein turnover, chaperones 75677117 Common - Heat shock protein Hsp20 Nwi_2936 76 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 75675658 Common - rare lipoprotein A Nwi_1466 137 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 75676369 Common - peptidase M29, aminopeptidase II Nwi_2184 56 COG2309 AmpS, Leucyl aminopeptidase (aminopeptidase T) Amino acid transport and metabolism 75674247 Common - nucleotidyl transferase Nwi_0048 224 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 75676813 Common - hypothetical protein Nwi_2629 35 COG5426 COG5426, Uncharacterized membrane protein Function unknown 75675515 Common - ISCc1, transposase OrfB Nwi_1323 60 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675179 Common - pyruvate kinase Nwi_0986 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 75675511 Nonpathogen - hypothetical protein Nwi_1319 1 None None None 75674676 Common - Protein of unknown function YGGT Nwi_0478 32 None None None 75674647 Common - peptidase S41A Nwi_0449 183 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 75675989 Common - peptidyl-prolyl cis-trans isomerase, cyclophilin type Nwi_1797 201 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 75675665 Common - phage terminase, small subunit, putative, P27 Nwi_1473 17 COG3747 COG3747, Phage terminase, small subunit DNA replication, recombination, and repair 75675218 Common - glucokinase Nwi_1025 90 COG0837 Glk, Glucokinase Carbohydrate transport and metabolism 75675387 Common - Cytochrome C biogenesis protein Nwi_1194 91 COG3088 CcmH, Uncharacterized protein involved in biosynthesis of c-type cytochromes Posttranslational modification, protein turnover, chaperones 75675028 Nonpathogen - hypothetical protein Nwi_0832 2 None None None 75674609 Common - 4Fe-4S ferredoxin, iron-sulfur binding Nwi_0411 162 COG2768 COG2768, Uncharacterized Fe-S center protein General function prediction only 75674875 Common - hypothetical protein Nwi_0678 214 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 75676573 Common - aminotransferase class-III Nwi_2388 235 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 75677184 Nonpathogen - hypothetical protein Nwi_3003 1 None None None 75675610 Common - cytochrome oxidase assembly Nwi_1418 69 COG1612 CtaA, Uncharacterized protein required for cytochrome oxidase assembly Posttranslational modification, protein turnover, chaperones 75675448 Nonpathogen - hypothetical protein Nwi_1256 1 None None None 75676661 Nonpathogen - hypothetical protein Nwi_2477 3 None None None 75675580 Common - DNA-directed RNA polymerase subunit alpha Nwi_1388 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 75675686 Nonpathogen - hypothetical protein Nwi_1494 1 None None None 75674264 Common pheT phenylalanyl-tRNA synthetase subunit beta Nwi_0065 220 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 75675943 Common - 3-dehydroquinate dehydratase Nwi_1751 170 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 75675113 Nonpathogen - hypothetical protein Nwi_0920 1 None None None 75676201 Common - hypothetical protein Nwi_2011 5 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 75674489 Common - Binding-protein-dependent transport systems inner membrane component Nwi_0291 212 COG4239 COG4239, ABC-type uncharacterized transport system, permease component General function prediction only 75675366 Common - gene transfer agent (GTA) like protein Nwi_1173 14 None None None 75674340 Common - Camphor resistance CrcB protein Nwi_0141 181 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 75677261 Nonpathogen - transcriptional regulator AbrB Nwi_3083 9 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 75675241 Common mraY phospho-N-acetylmuramoyl-pentapeptide-transferase Nwi_1048 217 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 75675541 Common rplL 50S ribosomal protein L7/L12 Nwi_1349 215 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 75675672 Common - HNH endonuclease Nwi_1480 23 None None None 75677142 Nonpathogen - hypothetical protein Nwi_2961 4 None None None 75674581 Common - hypothetical protein Nwi_0383 25 COG5319 COG5319, Uncharacterized protein conserved in bacteria Function unknown 75674931 Common - IS511, transposase OrfB Nwi_0734 39 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675723 Common - lipid A biosynthesis Nwi_1531 22 COG3952 COG3952, Predicted membrane protein Function unknown 75674312 Common - beta-lactamase-like Nwi_0113 215 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 75674938 Common - DSBA oxidoreductase Nwi_0741 96 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 75676758 Common groEL chaperonin GroEL Nwi_2574 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 75676322 Common - transposase IS3/IS911 Nwi_2136 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674701 Nonpathogen - hypothetical protein Nwi_0503 3 None None None 75675738 Common - DNA methylase N-4/N-6 Nwi_1546 90 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 75676091 Common tig trigger factor Nwi_1900 211 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 75676468 Common - Acriflavin resistance protein Nwi_2283 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 75675200 Common - Binding-protein-dependent transport systems inner membrane component Nwi_1007 190 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 75676160 Common - FecR protein Nwi_1969 48 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 75676553 Common - peptidase M24 Nwi_2368 238 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 75674213 Common - tRNA-i(6)A37 modification enzyme MiaB Nwi_0014 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 75675660 Nonpathogen - hypothetical protein Nwi_1468 1 None None None 75676057 Common - nuclear export factor GLE1 Nwi_1866 28 COG4549 COG4549, Uncharacterized protein conserved in bacteria Function unknown 75675931 Common - Zinc-containing alcohol dehydrogenase superfamily Nwi_1739 190 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 75675393 Common - Signal transduction histidine kinase Nwi_1200 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 75677185 Common - TPR repeat protein Nwi_3004 59 COG3899 COG3899, Predicted ATPase General function prediction only 75675314 Common flgG flagellar basal body rod protein FlgG Nwi_1121 126 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 75676976 Common - carbonic anhydrase Nwi_2792 150 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 75676610 Common - L-aspartate oxidase Nwi_2425 225 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 75676581 Common - NeuB, Antifreeze-like protein Nwi_2396 78 COG2089 SpsE, Sialic acid synthase Cell envelope biogenesis, outer membrane 75675877 Common - aminodeoxychorismate lyase Nwi_1685 185 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 75674984 Nonpathogen - hypothetical protein Nwi_0788 1 None None None 75675153 Nonpathogen - hypothetical protein Nwi_0960 1 None None None 75675056 Common - hypothetical protein Nwi_0861 23 COG5639 COG5639, Uncharacterized conserved small protein Function unknown 75675234 Nonpathogen - hypothetical protein Nwi_1041 1 None None None 75675799 Nonpathogen - hypothetical protein Nwi_1607 1 None None None 75674881 Common - ABC transporter, ATPase subunit Nwi_0684 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 75674433 Common - hypothetical protein Nwi_0234 8 None None None 75676155 Common - helix-turn-helix, Fis-type Nwi_1964 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676330 Nonpathogen - hypothetical protein Nwi_2145 1 None None None 75676457 Common - squalene/phytoene synthase Nwi_2272 80 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 75677278 Common lpxD UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase Nwi_3100 196 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 75675236 Common - methyltransferase Nwi_1043 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 75674307 Common - Membrane-bound lytic murein transglycosylase Nwi_0108 93 COG2821 MltA, Membrane-bound lytic murein transglycosylase Cell envelope biogenesis, outer membrane 75676010 Common - dehydrogenase, E1 component Nwi_1818 153 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 75676114 Common - DNA-directed RNA polymerase subunit omega Nwi_1923 115 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 75674300 Common - hypothetical protein Nwi_0101 96 COG1981 COG1981, Predicted membrane protein Function unknown 75676908 Common ruvB Holliday junction DNA helicase B Nwi_2724 234 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 75677270 Common - plasmid stabilization system Nwi_3092 11 COG3668 ParE, Plasmid stabilization system protein General function prediction only 75676450 Common - hypothetical protein Nwi_2265 58 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 75675480 Nonpathogen - hypothetical protein Nwi_1288 1 None None None 75674718 Common - CheA kinase Nwi_0520 209 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 75675431 Common - K+ potassium transporter Nwi_1238 88 COG3158 Kup, K+ transporter Inorganic ion transport and metabolism 75675254 Common - DNA repair protein RecN Nwi_1061 192 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 75676382 Common - Protein of unknown function DUF1130 Nwi_2197 53 COG5483 COG5483, Uncharacterized conserved protein Function unknown 75674896 Common - phosphatidylserine decarboxylase Nwi_0699 94 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 75675331 Common - Signal transduction histidine kinase Nwi_1138 225 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 75676593 Common - transposase IS3/IS911 Nwi_2408 33 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676212 Common - hypothetical protein Nwi_2022 18 COG4649 COG4649, Uncharacterized protein conserved in bacteria Function unknown 75674685 Common - short chain dehydrogenase Nwi_0487 221 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 75676955 Common - two-component response regulator Nwi_2771 94 COG4565 CitB, Response regulator of citrate/malate metabolism Transcription / Signal transduction mechanisms 75676964 Common rpsP 30S ribosomal protein S16 Nwi_2780 213 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 75674727 Common flhA flagellar biosynthesis protein A Nwi_0529 127 COG1298 FlhA, Flagellar biosynthesis pathway, component FlhA Cell motility and secretion / Intracellular trafficking and secretion 75674812 Common - hypothetical protein Nwi_0614 24 COG4446 COG4446, Uncharacterized protein conserved in bacteria Function unknown 75674317 Common - Mg chelatase-related protein Nwi_0118 192 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 75676831 Common - PAS sensor diguanylate cyclase/phophodiesterase Nwi_2647 177 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 75676877 Common - Phosphoribulokinase/uridine kinase Nwi_2693 51 COG3954 PrkB, Phosphoribulokinase Energy production and conversion 75676682 Common - transposase, IS4 Nwi_2498 62 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675885 Common - hypothetical protein Nwi_1693 13 None None None 75676219 Common - ISRm2011-2 transposase protein Nwi_2029 40 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674639 Common - GCN5-related N-acetyltransferase Nwi_0441 124 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 75676050 Common rpsB 30S ribosomal protein S2 Nwi_1859 217 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 75675637 Common - helix-turn-helix, Fis-type / Nitrogen regulation protein NR(I) Nwi_1445 220 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 75675701 Common - Invasion associated locus B Nwi_1509 14 COG5342 COG5342, Invasion protein B, involved in pathogenesis General function prediction only 75676825 Common - bifunctional transaldolase/phosoglucose isomerase Nwi_2641 196 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 75676379 Common - hypothetical protein Nwi_2194 39 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 75676708 Common - molybdopterin converting factor, subunit 1 Nwi_2524 62 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 75676778 Common - TPR repeat protein Nwi_2594 142 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 75677011 Nonpathogen - hypothetical protein Nwi_2827 2 None None None 75674502 Nonpathogen - Flp/Fap pilin component Nwi_0304 2 COG3847 Flp, Flp pilus assembly protein, pilin Flp Intracellular trafficking and secretion 75676436 Nonpathogen - hypothetical protein Nwi_2251 3 None None None 75675487 Common - RNA methyltransferase TrmH, group 1 Nwi_1295 157 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 75676318 Nonpathogen - hypothetical protein Nwi_2132 9 None None None 75674920 Nonpathogen - hypothetical protein Nwi_0723 2 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75674568 Common - Histidine triad (HIT) protein Nwi_0370 65 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 75674823 Nonpathogen - hypothetical protein Nwi_0625 1 None None None 75677238 Common - polyhydroxyalkanoate synthesis repressor PhaR Nwi_3059 65 COG5394 COG5394, Uncharacterized protein conserved in bacteria Function unknown 75676518 Nonpathogen - hypothetical protein Nwi_2333 2 None None None 75675343 Common - Penicillin-binding protein 1A Nwi_1150 202 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 75677034 Common - Na+/H+ antiporter NhaA Nwi_2853 106 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 75675038 Common - transcriptional regulator, XRE family Nwi_0843 47 COG1396 HipB, Predicted transcriptional regulators Transcription 75674274 Common - Protein of unknown function DUF343 Nwi_0075 102 COG2835 COG2835, Uncharacterized conserved protein Function unknown 75675965 Common - Protein-L-isoaspartate(D-aspartate) O-methyltransferase Nwi_1773 157 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 75677240 Common - acetoacetyl-CoA reductase Nwi_3061 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 75676619 Common - transposase IS3/IS911 Nwi_2434 33 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676948 Common - adenylylsulfate kinase Nwi_2764 249 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 75674897 Common - TonB-dependent receptor Nwi_0700 87 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 75676311 Nonpathogen - hypothetical protein Nwi_2125 4 None None None 75676605 Common bioD dithiobiotin synthetase Nwi_2420 155 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 75674950 Common - electron transfer flavoprotein alpha and beta-subunits Nwi_0754 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 75676036 Common gltA type II citrate synthase Nwi_1845 192 COG0372 GltA, Citrate synthase Energy production and conversion 75674650 Common - peptidase M48, Ste24p Nwi_0452 127 COG4784 COG4784, Putative Zn-dependent protease General function prediction only 75677301 Common - Transcriptional regulatory protein, ArsR family Nwi_3123 67 COG0640 ArsR, Predicted transcriptional regulators Transcription 75674457 Common - hypothetical protein Nwi_0259 9 None None None 75674385 Common - metallophosphoesterase Nwi_0186 52 COG1407 COG1407, Predicted ICC-like phosphoesterases General function prediction only 75674959 Common - protoheme IX farnesyltransferase Nwi_0763 169 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 75676415 Nonpathogen - hypothetical protein Nwi_2230 5 None None None 75676599 Nonpathogen - hypothetical protein Nwi_2414 3 None None None 75676049 Common tsf elongation factor Ts Nwi_1858 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 75676711 Common - putative outer-membrane immunogenic protein precursor Nwi_2527 20 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 75675294 Common - hypothetical protein Nwi_1101 13 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 75675415 Common - hypothetical protein Nwi_1222 15 COG3184 COG3184, Uncharacterized protein conserved in bacteria Function unknown 75675504 Common - Glutaredoxin-related protein Nwi_1312 127 COG0278 COG0278, Glutaredoxin-related protein Posttranslational modification, protein turnover, chaperones 75676199 Common - hypothetical protein Nwi_2009 170 COG0344 COG0344, Predicted membrane protein Function unknown 75674467 Common - N-6 DNA methylase Nwi_0269 157 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 75674476 Nonpathogen - hypothetical protein Nwi_0278 3 None None None 75675359 Nonpathogen - hypothetical protein Nwi_1166 2 None None None 75676799 Common - YbhB and YbcL Nwi_2615 126 COG1881 COG1881, Phospholipid-binding protein General function prediction only 75676291 Common - integrase Nwi_2105 76 None None None 75676991 Common - hypothetical protein Nwi_2807 33 COG5342 COG5342, Invasion protein B, involved in pathogenesis General function prediction only 75675176 Common rpmJ 50S ribosomal protein L36 Nwi_0983 63 None None None 75676107 Nonpathogen - hypothetical protein Nwi_1916 1 None None None 75674721 Common - chemotaxis-specific methylesterase Nwi_0523 212 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 75674372 Common - OstA-like protein Nwi_0173 34 COG1934 COG1934, Uncharacterized protein conserved in bacteria Function unknown 75675238 Common - Penicillin-binding protein, transpeptidase Nwi_1045 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 75676539 Nonpathogen - hypothetical protein Nwi_2354 1 None None None 75676614 Common - diguanylate cyclase Nwi_2429 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 75675407 Common - glyoxalase/bleomycin resistance protein/dioxygenase Nwi_1214 32 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 75674819 Common - Short-chain dehydrogenase/reductase SDR Nwi_0621 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 75674975 Common - major facilitator superfamily MFS_1 Nwi_0779 100 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 75676325 Common - transcriptional regulator, LysR family Nwi_2140 10 None None None 75677077 Common - diguanylate cyclase Nwi_2896 171 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 75675352 Nonpathogen - hypothetical protein Nwi_1159 2 None None None 75677131 Common - histidinol-phosphate phosphatase, putative, inositol monophosphatase Nwi_2950 190 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 75676882 Common - Protein of unknown function DUF159 Nwi_2698 107 COG2135 COG2135, Uncharacterized conserved protein Function unknown 75674223 Common infB translation initiation factor IF-2 Nwi_0024 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 75674546 Common - Transcriptional regulatory protein Nwi_0348 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 75676164 Common - hypothetical protein Nwi_1974 18 None None None 75676425 Common - arginine/ornithine transport system ATPase Nwi_2240 99 COG1703 ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family Amino acid transport and metabolism 75674864 Common - ABC-type branched-chain amino acid transport systems periplasmic component Nwi_0667 61 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 75675262 Common - lipopolysaccharide heptosyltransferase II Nwi_1069 95 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 75675003 Common - peptidase U35, phage prohead HK97 Nwi_0807 22 None None None 75674907 Nonpathogen - hypothetical protein Nwi_0710 3 None None None 75676408 Common - Fe-S metabolism associated SufE Nwi_2223 93 COG2166 COG2166, SufE protein probably involved in Fe-S center assembly General function prediction only 75675957 Common - serine/threonine protein kinase Nwi_1765 8 COG2112 COG2112, Predicted Ser/Thr protein kinase Signal transduction mechanisms 75674797 Common fliF flagellar MS-ring protein Nwi_0599 129 COG1766 FliF, Flagellar biosynthesis/type III secretory pathway lipoprotein Cell motility and secretion / Intracellular trafficking and secretion 75674845 Common - NUDIX hydrolase Nwi_0648 5 None None None 75674840 Common - DegT/DnrJ/EryC1/StrS aminotransferase Nwi_0642 192 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 75676135 Common - transposase IS3/IS911 Nwi_1944 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676783 Common - small multidrug resistance protein Nwi_2599 143 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 75675350 Common - ISRm2011-2 transposase protein Nwi_1157 38 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676633 Common carB carbamoyl phosphate synthase large subunit Nwi_2449 232 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 75674238 Nonpathogen - hypothetical protein Nwi_0039 8 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 75674731 Common - hemolysin-type calcium-binding region Nwi_0533 90 None None None 75675537 Common nusG transcription antitermination protein NusG Nwi_1345 215 COG0250 NusG, Transcription antiterminator Transcription 75675681 Nonpathogen - hypothetical protein Nwi_1489 2 None None None 75676515 Common - transposase IS3/IS911 Nwi_2330 30 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674296 Common - tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA Nwi_0097 191 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 75674342 Nonpathogen - hypothetical protein Nwi_0143 3 None None None 75674583 Common - phosphoribosyltransferase Nwi_0385 160 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 75675612 Common - O-acetylhomoserine aminocarboxypropyltransferase Nwi_1420 206 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 75676590 Common - DegT/DnrJ/EryC1/StrS aminotransferase Nwi_2405 191 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 75675380 Common - two component transcriptional regulatory protein Nwi_1187 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 75674831 Common - 1-deoxy-D-xylulose-5-phosphate synthase Nwi_0633 226 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 75676246 Nonpathogen - hypothetical protein Nwi_2057 1 None None None 75674781 Common - histidinol-phosphate aminotransferase Nwi_0583 238 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 75676443 Common - Elongator protein 3/MiaB/NifB Nwi_2258 55 COG4277 COG4277, Predicted DNA-binding protein with the Helix-hairpin-helix motif General function prediction only 75674421 Common - invasion associated locus B Nwi_0222 13 COG5342 COG5342, Invasion protein B, involved in pathogenesis General function prediction only 75677232 Common - Transcriptional regulatory protein, TetR family Nwi_3052 97 COG1309 AcrR, Transcriptional regulator Transcription 75675090 Common - FecR protein Nwi_0895 42 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 75677284 Common - helix-turn-helix, Fis-type Nwi_3106 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 162139852 Common - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase Nwi_0123 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 75675529 Common - putative outer membrane protein Nwi_1337 17 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 75675706 Common - Protein of unknown function DUF339 Nwi_1514 33 COG2938 COG2938, Uncharacterized conserved protein Function unknown 75675069 Common - Protein of unknown function DUF490 Nwi_0874 72 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 75676131 Common - CRISPR-associated CT1134 family protein Nwi_1940 36 None None None 75676733 Common - Conserved hypothetical protein 95 Nwi_2549 210 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 75675278 Common - mandelate racemase/muconate lactonizing enzyme Nwi_1085 100 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 75675204 Common - coenzyme A transferase Nwi_1011 99 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 75675717 Common - cysteine synthase A Nwi_1525 225 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 75675925 Common - FecR protein Nwi_1733 44 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 75675248 Common - D-alanine--D-alanine ligase Nwi_1055 211 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 75676002 Common - Exodeoxyribonuclease III xth Nwi_1810 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 75676869 Common - Protein of unknown function DUF924 Nwi_2685 63 COG3803 COG3803, Uncharacterized protein conserved in bacteria Function unknown 75675871 Common - Organic solvent tolerance protein Nwi_1679 114 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 75674698 Common - diguanylate cyclase/phophodiesterase Nwi_0500 172 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 75674499 Common - type II and III secretion system protein Nwi_0301 134 COG4964 CpaC, Flp pilus assembly protein, secretin CpaC Intracellular trafficking and secretion 75674615 Common - 2',5' RNA ligase Nwi_0417 114 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 75676475 Common - MaoC-like dehydratase Nwi_2290 96 COG2030 MaoC, Acyl dehydratase Lipid metabolism 75677213 Common - transcriptional regulatory protein, Crp family Nwi_3032 167 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 75677070 Common - Protein of unknown function DUF208 Nwi_2889 67 COG1636 COG1636, Uncharacterized protein conserved in bacteria Function unknown 75674601 Common - cobalt chelatase, pCobS small subunit Nwi_0403 70 COG0714 COG0714, MoxR-like ATPases General function prediction only 75674512 Common - DEAD/DEAH box helicase Nwi_0314 235 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 75675644 Common mazG nucleoside triphosphate pyrophosphohydrolase Nwi_1452 157 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 75676615 Common - RNA polymerase factor sigma-32 Nwi_2430 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 75677075 Nonpathogen - hypothetical protein Nwi_2894 12 COG1416 COG1416, Uncharacterized conserved protein Function unknown 75676190 Nonpathogen - hypothetical protein Nwi_2000 13 None None None 75675072 Common - hypothetical protein Nwi_0877 53 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 75676304 Common - Heat shock protein Hsp20 Nwi_2118 155 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 75675830 Common - phosphoesterase, PA-phosphatase related Nwi_1638 9 None None None 75677315 Nonpathogen - hypothetical protein Nwi_3137 1 None None None 75674492 Common - peptidase M17, leucyl aminopeptidase Nwi_0294 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 75676290 Common - probable ISRm2011-2 transposase protein Nwi_2104 40 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675856 Common - cysteine desulfurase activator complex subunit SufB Nwi_1664 184 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 75677149 Common - D-3-phosphoglycerate dehydrogenase Nwi_2968 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 75675087 Common - Transcriptional regulatory protein, ArsR family Nwi_0892 130 COG0640 ArsR, Predicted transcriptional regulators Transcription 75675710 Nonpathogen - hypothetical protein Nwi_1518 3 None None None 75676045 Common - phosphatidate cytidylyltransferase Nwi_1854 203 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 75674416 Common - virulence factor MVIN-like Nwi_0217 188 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 75674503 Common - hypothetical protein Nwi_0305 16 COG4964 CpaC, Flp pilus assembly protein, secretin CpaC Intracellular trafficking and secretion 75675577 Common adk adenylate kinase Nwi_1385 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 75674517 Nonpathogen - Heme exporter protein D (CcmD) Nwi_0319 1 None None None 75676405 Nonpathogen - hypothetical protein Nwi_2220 6 None None None 75674395 Nonpathogen - hypothetical protein Nwi_0196 6 None None None 75675140 Nonpathogen - hypothetical protein Nwi_0947 1 None None None 75676672 Common - ErfK/YbiS/YcfS/YnhG Nwi_2488 84 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 75674381 Common - glutamate--cysteine ligase Nwi_0182 55 COG3572 GshA, Gamma-glutamylcysteine synthetase Coenzyme metabolism 75674982 Nonpathogen - hypothetical protein Nwi_0786 1 None None None 75677167 Common - transcriptional regulator, XRE family Nwi_2986 52 COG3800 COG3800, Predicted transcriptional regulator General function prediction only 75676763 Common - 4Fe-4S ferredoxin, iron-sulfur binding Nwi_2579 165 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 75677253 Common - putative inner membrane protein translocase component YidC Nwi_3074 215 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 75676568 Common - glycosyl transferase, family 4 Nwi_2383 46 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 75675820 Common - Phage portal protein, HK97 Nwi_1628 50 COG4695 COG4695, Phage-related protein Function unknown 75676722 Common - diguanylate phophodiesterase Nwi_2538 130 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 75674762 Nonpathogen - hypothetical protein Nwi_0564 5 None None None 75674964 Common - surfeit locus 1 Nwi_0768 35 COG3346 COG3346, Uncharacterized conserved protein Function unknown 75675306 Common - DnaK suppressor protein DksA Nwi_1113 157 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 75676302 Common - hypothetical protein Nwi_2116 24 COG5425 COG5425, Usg protein, probable subunit of phosphoribosylanthranilate isomerase Amino acid transport and metabolism 75676265 Common - TonB-dependent receptor Nwi_2076 84 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 75676917 Common - hypothetical protein Nwi_2733 7 None None None 75676105 Common - DNA topoisomerase IV subunit A Nwi_1914 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 75676123 Common - helix-turn-helix, Fis-type Nwi_1932 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674366 Common - TPR repeat protein Nwi_0167 52 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 75675973 Nonpathogen - hypothetical protein Nwi_1781 1 None None None 75676284 Common - possible conjugal transfer protein TrbJ Nwi_2096 33 COG5314 COG5314, Conjugal transfer/entry exclusion protein Intracellular trafficking and secretion 75675862 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Nwi_1670 202 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 75676583 Common - UDP-N-acetylglucosamine 2-epimerase Nwi_2398 55 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 75676244 Nonpathogen - hypothetical protein Nwi_2055 1 None None None 75675316 Common fliL flagellar basal body-associated protein FliL Nwi_1123 14 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 75677176 Common fadE acyl-CoA dehydrogenase Nwi_2995 147 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 75675082 Common - hypothetical protein Nwi_0887 3 None None None 75675011 Common - hypothetical protein Nwi_0815 12 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 75674536 Common - molybdate ABC transporter, ATP-binding protein Nwi_0338 249 COG4148 ModC, ABC-type molybdate transport system, ATPase component Inorganic ion transport and metabolism 75676807 Nonpathogen - hypothetical protein Nwi_2623 3 None None None 75676747 Nonpathogen - hypothetical protein Nwi_2563 7 COG5243 HRD1, HRD ubiquitin ligase complex, ER membrane component Posttranslational modification, protein turnover, chaperones 75676486 Common - Siderophore synthetase component Nwi_2301 50 COG4264 RhbC, Siderophore synthetase component Secondary metabolites biosynthesis, transport, and catabolism 75674526 Common - amylo-alpha-1,6-glucosidase Nwi_0328 45 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 75675749 Common - hypothetical protein Nwi_1557 30 COG3750 COG3750, Uncharacterized protein conserved in bacteria Function unknown 75676551 Nonpathogen - hypothetical protein Nwi_2366 1 None None None 75675144 Common - para-aminobenzoate synthase, component I Nwi_0951 223 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 75677220 Common - Secretion protein HlyD Nwi_3039 71 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 75674455 Common - hypothetical protein Nwi_0257 23 None None None 75674285 Common - cyclic nucleotide-binding protein Nwi_0086 50 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 75677229 Common - ABC transporter, ATPase subunit Nwi_3049 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 75675766 Common - hypothetical protein Nwi_1574 20 None None None 75675564 Common - 50S ribosomal protein L29 Nwi_1372 167 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 75676398 Common - extracellular ligand-binding receptor Nwi_2213 146 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 75676984 Common sdhA succinate dehydrogenase flavoprotein subunit Nwi_2800 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 75677218 Common - transposase, IS4 Nwi_3037 62 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675603 Common - hypothetical protein Nwi_1411 12 None None None 75674934 Common - resolvase Nwi_0737 60 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 75675850 Common - diguanylate cyclase Nwi_1658 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 75677101 Common - ISBm1, transposase orfA Nwi_2920 78 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675555 Common rpsJ 30S ribosomal protein S10 Nwi_1363 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 75676065 Common - NADH dehydrogenase subunit N Nwi_1874 209 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 75674572 Common - hypothetical protein Nwi_0374 51 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 75676276 Common - Y4BN Nwi_2088 27 None None None 75674430 Common - GCN5-related N-acetyltransferase Nwi_0231 128 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 75674661 Common - hypothetical protein Nwi_0463 14 None None None 75674973 Common - nitrate reductase, delta subunit Nwi_0777 20 COG2180 NarJ, Nitrate reductase delta subunit Energy production and conversion 75675454 Common - hypothetical protein Nwi_1262 7 COG2856 COG2856, Predicted Zn peptidase Amino acid transport and metabolism 75675920 Nonpathogen - hypothetical protein Nwi_1728 1 None None None 75674814 Common - pirin Nwi_0616 146 COG1741 COG1741, Pirin-related protein General function prediction only 75675838 Common glpX fructose 1,6-bisphosphatase II Nwi_1646 112 COG1494 GlpX, Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins Carbohydrate transport and metabolism 75676298 Common - glycosyl transferase, group 1 Nwi_2112 128 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 75675806 Nonpathogen - hypothetical protein Nwi_1614 2 None None None 75675938 Nonpathogen - hypothetical protein Nwi_1746 2 None None None 75677194 Common - transposase, IS4 Nwi_3013 62 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676493 Nonpathogen - hypothetical protein Nwi_2308 2 None None None 75674915 Nonpathogen - hypothetical protein Nwi_0718 1 None None None 75674900 Common - MotA/TolQ/ExbB proton channel Nwi_0703 128 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 75675947 Common - response regulator receiver Nwi_1755 85 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 75676502 Nonpathogen - hypothetical protein Nwi_2317 3 None None None 75674336 Common - hypothetical protein Nwi_0137 9 None None None 75675438 Common - 3-hydroxymyristoyl-acyl carrier protein dehydratase Nwi_1245 184 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 75675741 Common - Transcription antitermination protein nusG Nwi_1549 155 COG0250 NusG, Transcription antiterminator Transcription 75677025 Common - IstB-like ATP-binding protein Nwi_2842 82 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 75675585 Nonpathogen - hypothetical protein Nwi_1393 4 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 75674627 Common - F0F1 ATP synthase subunit delta Nwi_0429 188 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 75674910 Common - diaminopimelate decarboxylase Nwi_0713 219 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 75675095 Nonpathogen - hypothetical protein Nwi_0902 2 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 75676926 Common - Secretion protein HlyD Nwi_2742 126 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 162139845 Common metG methionyl-tRNA synthetase Nwi_1462 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 75677095 Common - Signal transduction histidine kinase Nwi_2914 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 75676703 Common - Transcriptional regulatory protein, MarR family Nwi_2519 47 COG1846 MarR, Transcriptional regulators Transcription 75675950 Common - hypothetical protein Nwi_1758 28 COG4765 COG4765, Uncharacterized protein conserved in bacteria Function unknown 75676166 Common - ATPase associated with various cellular activities, AAA_5 Nwi_1976 75 COG0714 COG0714, MoxR-like ATPases General function prediction only 75676238 Common - TonB-dependent siderophore receptor Nwi_2049 101 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 75674248 Common - hypothetical protein Nwi_0049 50 COG3893 COG3893, Inactivated superfamily I helicase DNA replication, recombination, and repair 75676289 Common - transposase Nwi_2103 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675304 Common flgI flagellar basal body P-ring protein Nwi_1111 105 COG1706 FlgI, Flagellar basal-body P-ring protein Cell motility and secretion 75676811 Common - hypothetical protein Nwi_2627 59 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 75676459 Nonpathogen - hypothetical protein Nwi_2274 4 None None None 75677019 Nonpathogen - hypothetical protein Nwi_2836 1 None None None 75675847 Common - hypothetical protein Nwi_1655 103 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 75674570 Common - Protein of unknown function DUF985 Nwi_0372 57 COG3542 COG3542, Uncharacterized conserved protein Function unknown 75676179 Common - hypothetical protein Nwi_1989 13 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 75677303 Common - arsenate reductase Nwi_3125 110 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 75675513 Common - hypothetical protein Nwi_1321 150 COG0517 COG0517, FOG: CBS domain General function prediction only 75677125 Common - putative bacteriophage-related protein Nwi_2944 19 None None None 75677060 Common - helix-turn-helix, Fis-type Nwi_2879 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674873 Common - PBS lyase HEAT-like repeat Nwi_0676 46 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 75675639 Common - Nitrogen assimilation regulatory protein ntrX Nwi_1447 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 75675243 Common - Cell cycle protein Nwi_1050 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 75675389 Common - Two-component transcriptional regulator, winged helix family Nwi_1196 220 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 75675517 Common - hypothetical protein Nwi_1325 13 None None None 75675987 Common tgt queuine tRNA-ribosyltransferase Nwi_1795 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 75675594 Common - hypothetical protein Nwi_1402 11 None None None 75675795 Nonpathogen - hypothetical protein Nwi_1603 1 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 75676206 Common - Colicin V production protein Nwi_2016 46 COG1286 CvpA, Uncharacterized membrane protein, required for colicin V production General function prediction only 75675582 Nonpathogen - hypothetical protein Nwi_1390 1 None None None 75675667 Nonpathogen - phage head-tail adaptor, putative Nwi_1475 6 COG5614 COG5614, Bacteriophage head-tail adaptor General function prediction only 75676064 Common - biotin--protein ligase Nwi_1873 149 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 75676370 Nonpathogen - hypothetical protein Nwi_2185 1 None None None 75677004 Common - transposase IS3/IS911 Nwi_2820 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674326 Common - ATP-dependent protease peptidase subunit Nwi_0127 149 COG5405 HslV, ATP-dependent protease HslVU (ClpYQ), peptidase subunit Posttranslational modification, protein turnover, chaperones 75674952 Common - Cobalamin synthesis protein, CobW Nwi_0756 127 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 75675111 Common - WD-40 repeat protein Nwi_0918 47 COG2319 COG2319, FOG: WD40 repeat General function prediction only 75674310 Common - helix-turn-helix, Fis-type Nwi_0111 207 COG4567 COG4567, Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain Signal transduction mechanisms / Transcription 75675189 Common - NAD(P) transhydrogenase subunit alpha part Nwi_0996 117 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 75675722 Common - cystathionine beta-lyase Nwi_1530 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 75676069 Common - NADH dehydrogenase subunit J Nwi_1878 161 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 75676089 Common clpX ATP-dependent protease ATP-binding subunit Nwi_1898 226 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 75676236 Common - helix-turn-helix, Fis-type Nwi_2047 119 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676663 Common - lytic murein transglycosylase Nwi_2479 102 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 75675180 Common - Protein of unknown function DUF1036 Nwi_0987 18 COG5480 COG5480, Predicted integral membrane protein Function unknown 75674769 Common - putative methylated-DNA-protein-cystein methyltransferase Nwi_0571 10 None None None 75676696 Common - 50S ribosomal protein L25/general stress protein Ctc Nwi_2512 165 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 75676885 Common - hypothetical protein Nwi_2701 16 COG5451 COG5451, Predicted secreted protein Function unknown 75676360 Common - hypothetical protein Nwi_2175 19 None None None 75676013 Common - isoprenylcysteine carboxyl methyltransferase Nwi_1821 23 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 75675534 Nonpathogen - hypothetical protein Nwi_1342 1 None None None 75677148 Common - peptidase S10, serine carboxypeptidase Nwi_2967 38 COG2939 COG2939, Carboxypeptidase C (cathepsin A) Amino acid transport and metabolism 75676172 Common - Ethanolamine utilization protein EutN/carboxysome structural protein Ccml Nwi_1982 9 COG4576 CcmL, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 75674933 Nonpathogen - hypothetical protein Nwi_0736 1 None None None 162139843 Common secG preprotein translocase subunit SecG Nwi_1834 18 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 75676753 Common - hypothetical protein Nwi_2569 7 COG3416 COG3416, Uncharacterized protein conserved in bacteria Function unknown 75674868 Common - ABC-type nitrate/sulfonate/bicarbonate transport system ATPase component Nwi_0671 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 75676263 Common - ABC transporter, ATPase subunit Nwi_2074 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 75676428 Common - Nitrous oxidase accessory protein Nwi_2243 14 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 75675548 Common - hypothetical protein Nwi_1356 28 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 75676492 Common - TonB like protein Nwi_2307 20 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 75676274 Nonpathogen - hypothetical protein Nwi_2086 1 None None None 75676988 Common - phosphoesterase, PA-phosphatase related Nwi_2804 16 COG3907 COG3907, PAP2 (acid phosphatase) superfamily protein General function prediction only 75677155 Nonpathogen - hypothetical protein Nwi_2974 1 None None None 75674747 Common - glycosyl transferase, family 2 Nwi_0549 72 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 75674660 Common - ATP-dependent DNA ligase Nwi_0462 100 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 75676228 Common - TonB like protein Nwi_2038 14 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 75675107 Common - ABC transporter, ATPase subunit Nwi_0914 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 75676487 Common - Siderophore synthetase component Nwi_2302 41 COG4264 RhbC, Siderophore synthetase component Secondary metabolites biosynthesis, transport, and catabolism 75676146 Nonpathogen - hypothetical protein Nwi_1955 6 None None None 75675391 Common - Signal transduction histidine kinase Nwi_1198 204 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 75675427 Common - phosphatidylserine decarboxylase Nwi_1234 94 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 75675021 Nonpathogen - hypothetical protein Nwi_0825 3 None None None 75675630 Common - 3-methyladenine DNA glycosylase Nwi_1438 77 COG2094 Mpg, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 75677254 Common - ribonuclease P protein Nwi_3075 30 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 75675134 Common - TonB-dependent receptor Nwi_0941 107 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 75675695 Common - hypothetical protein Nwi_1503 100 COG1540 COG1540, Uncharacterized proteins, homologs of lactam utilization protein B General function prediction only 75675910 Common - ISBm1, transposase orfA Nwi_1718 78 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75677319 Nonpathogen - hypothetical protein Nwi_3141 3 None None None 75674591 Common - tyrosine recombinase XerD Nwi_0393 220 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 75675815 Common - hypothetical protein Nwi_1623 3 None None None 75676674 Common - Rhodanese-related sulfurtransferase Nwi_2490 145 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 75675133 Nonpathogen - hypothetical protein Nwi_0940 4 None None None 75677087 Common - Protein of unknown function DUF1007 Nwi_2906 35 COG3683 COG3683, ABC-type uncharacterized transport system, periplasmic component General function prediction only 75675227 Nonpathogen - hypothetical protein Nwi_1034 9 None None None 75675426 Common - ABC transporter, transmembrane region Nwi_1233 249 COG5265 ATM1, ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components Posttranslational modification, protein turnover, chaperones 75677089 Nonpathogen - hypothetical protein Nwi_2908 1 None None None 75674484 Common - 3-deoxy-manno-octulosonate cytidylyltransferase Nwi_0286 141 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 75676055 Common - lipoprotein releasing system, transmembrane protein, LolC/E family Nwi_1864 164 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 75674634 Common - Protein of unknown function DUF450 Nwi_0436 2 COG4096 HsdR, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 75675497 Common - phosphoribosylformylglycinamidine synthase subunit PurS Nwi_1305 82 COG1828 PurS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component Nucleotide transport and metabolism 75676027 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Nwi_1836 137 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 75676720 Common - TadE-like protein Nwi_2536 11 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 75676846 Common - short-chain dehydrogenase/reductase SDR Nwi_2662 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 75675625 Common rpmG 50S ribosomal protein L33 Nwi_1433 123 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 75675329 Common fliR flagellar biosynthesis protein FliR Nwi_1136 128 COG1684 FliR, Flagellar biosynthesis pathway, component FliR Cell motility and secretion / Intracellular trafficking and secretion 75674699 Common - polysaccharide deacetylase Nwi_0501 50 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 75676657 Common - transposase, IS4 Nwi_2473 62 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676715 Nonpathogen - hypothetical protein Nwi_2531 3 None None None 75675961 Common secD preprotein translocase subunit SecD Nwi_1769 218 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 75676348 Nonpathogen - hypothetical protein Nwi_2163 3 None None None 75675777 Common - polysaccharide deacetylase Nwi_1585 95 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 75675975 Nonpathogen - hypothetical protein Nwi_1783 1 None None None 75676701 Common - Signal transduction histidine kinase Nwi_2517 214 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 75676626 Common - hypothetical protein Nwi_2442 9 None None None 75675142 Common - aspartate/glutamate/uridylate kinase Nwi_0949 46 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 75675013 Common - hypothetical protein Nwi_0817 9 None None None 75674575 Common prfA peptide chain release factor 1 Nwi_0377 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 75677294 Common - transposase, IS4 Nwi_3116 61 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675906 Common - hypothetical protein Nwi_1714 29 COG5349 COG5349, Uncharacterized protein conserved in bacteria Function unknown 75676523 Common - 2-isopropylmalate synthase Nwi_2338 216 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 75676796 Common - peptidase M48, Ste24p Nwi_2612 180 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 75676356 Common - peptidylprolyl isomerase, FKBP-type Nwi_2171 142 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 75674425 Nonpathogen - CoxF protein Nwi_0226 2 None None None 75677195 Common - transposase Nwi_3014 76 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676461 Common - Fe-S oxidoreductase Nwi_2276 82 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 75674514 Common - cell division transporter substrate-binding protein FtsY Nwi_0316 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 75676082 Nonpathogen - hypothetical protein Nwi_1891 5 None None None 75676871 Common - ribonuclease H Nwi_2687 175 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 75675967 Common surE stationary phase survival protein SurE Nwi_1775 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 75677082 Nonpathogen - hypothetical protein Nwi_2901 3 None None None 75674728 Common - methyl-accepting chemotaxis protein Nwi_0530 162 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 75675320 Nonpathogen - tetratricopeptide TPR_4 protein Nwi_1127 9 COG3266 DamX, Uncharacterized protein conserved in bacteria Function unknown 75674541 Common - GTP-binding protein LepA Nwi_0343 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 75674775 Common - Protein of unknown function DUF214 Nwi_0577 46 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 75675138 Common - hypothetical protein Nwi_0945 110 COG0397 COG0397, Uncharacterized conserved protein Function unknown 75677036 Common - hypothetical protein Nwi_2855 28 COG4453 COG4453, Uncharacterized protein conserved in bacteria Function unknown 75674990 Common - putative phage cell wall peptidase, NlpC/P60 Nwi_0794 21 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 75676210 Common engA GTP-binding protein EngA Nwi_2020 227 COG1160 COG1160, Predicted GTPases General function prediction only 75677264 Common - helix-turn-helix, Fis-type Nwi_3086 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674645 Common - Protein of unknown function DUF163 Nwi_0447 167 COG1576 COG1576, Uncharacterized conserved protein Function unknown 75676689 Common - Protein of unknown function DUF526 Nwi_2505 33 COG2960 COG2960, Uncharacterized protein conserved in bacteria Function unknown 75675995 Common - chromosome segregation and condensation protein ScpB Nwi_1803 132 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 75674500 Common - Flp pilus assembly CpaB Nwi_0302 59 COG3745 CpaB, Flp pilus assembly protein CpaB Intracellular trafficking and secretion 75675382 Common - LipA a lipoprotein Nwi_1189 20 COG4520 LipA, Surface antigen Cell envelope biogenesis, outer membrane 75677242 Common - major facilitator superfamily MFS_1 Nwi_3063 108 None None None 75674448 Common - low molecular weight phosphotyrosine protein phosphatase Nwi_0249 98 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 75675704 Nonpathogen - hypothetical protein Nwi_1512 3 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 75674786 Common - Uncharacterized Fe-S protein Nwi_0588 30 COG3217 COG3217, Uncharacterized Fe-S protein General function prediction only 75675755 Nonpathogen - hypothetical protein Nwi_1563 3 None None None 75677203 Common - Oxidoreductase, molybdopterin binding Nwi_3022 98 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 75676870 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Nwi_2686 82 COG0678 AHP1, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 75675477 Common - glycine cleavage H-protein Nwi_1285 185 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 75675527 Common ppnK inorganic polyphosphate/ATP-NAD kinase Nwi_1335 187 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 75674408 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Nwi_0209 229 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 75675486 Common - isocitrate dehydrogenase Nwi_1294 60 COG0538 Icd, Isocitrate dehydrogenases Energy production and conversion 75676034 Common - glutaminyl-tRNA synthetase Nwi_1843 243 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 75677249 Common - pyrimidine 5-nucleotidase Nwi_3070 46 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 75676965 Common - 16S rRNA processing protein RimM Nwi_2781 187 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 75674338 Common - O-succinylhomoserine sulfhydrylase Nwi_0139 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 75676076 Common - NADH dehydrogenase subunit D Nwi_1885 192 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 75676607 Common - hypothetical protein Nwi_2422 8 None None None 75676597 Common - ISBm1, transposase orfA Nwi_2412 78 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675341 Common - hypothetical protein Nwi_1148 15 COG5436 COG5436, Predicted integral membrane protein Function unknown 75675917 Common - Riboflavin biosynthesis protein RibD Nwi_1725 228 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 75676857 Common - transposase IS3/IS911 Nwi_2673 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675216 Common - hypothetical protein Nwi_1023 173 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 75676642 Common - extensin-like protein Nwi_2458 37 COG3921 COG3921, Uncharacterized protein conserved in bacteria Function unknown 75675125 Common - hypothetical protein Nwi_0932 17 COG5338 COG5338, Uncharacterized protein conserved in bacteria Function unknown 75674387 Common - possible outer membrane protein Nwi_0188 22 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 75675036 Common - hypothetical protein Nwi_0841 11 None None None 75676953 Nonpathogen - hypothetical protein Nwi_2769 3 None None None 75674944 Common - glutamyl-Q tRNA(Asp) synthetase Nwi_0748 242 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 75674890 Nonpathogen - hypothetical protein Nwi_0693 1 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 75676915 Common - 5-formyltetrahydrofolate cyclo-ligase Nwi_2731 186 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 75674380 Common - transposase Nwi_0181 76 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676946 Common - Uroporphyrin-III C-methyltransferase Nwi_2762 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 75674926 Nonpathogen - hypothetical protein Nwi_0729 1 None None None 75675674 Common - Phage major capsid protein, HK97 Nwi_1482 55 COG4653 COG4653, Predicted phage phi-C31 gp36 major capsid-like protein General function prediction only 75675229 Common fixK transcriptional regulator FixK Nwi_1036 140 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 75674899 Common - FMN-dependent alpha-hydroxy acid dehydrogenase Nwi_0702 110 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 75674687 Common - amine oxidase Nwi_0489 25 COG1231 COG1231, Monoamine oxidase Amino acid transport and metabolism 75676649 Common - ThiS, thiamine-biosynthesis Nwi_2465 44 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 75675422 Common - Protein of unknown function DUF559 Nwi_1229 44 COG2852 COG2852, Uncharacterized protein conserved in bacteria Function unknown 75675045 Common - lytic transglycosylase, catalytic Nwi_0850 140 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 75676668 Nonpathogen - hypothetical protein Nwi_2484 10 COG5304 COG5304, Uncharacterized protein conserved in bacteria Function unknown 75677187 Common - formate/nitrite transporter Nwi_3006 86 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 75677091 Common - RND efflux system, outer membrane lipoprotein, NodT Nwi_2910 99 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 75676380 Common - glycosyl transferase, family 2 Nwi_2195 152 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 75674215 Common - hypothetical protein Nwi_0016 204 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 75675788 Common - CDP-alcohol phosphatidyltransferase Nwi_1596 95 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 75676691 Common - MaoC-like dehydratase Nwi_2507 54 COG2030 MaoC, Acyl dehydratase Lipid metabolism 75677048 Common - transposase IS3/IS911 Nwi_2867 31 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 75675684 Common - helix-turn-helix, Fis-type Nwi_1492 119 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75674303 Common coaE dephospho-CoA kinase Nwi_0104 209 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 75677107 Common - transcriptional regulator, XRE family Nwi_2926 17 None None None 75675322 Common - hypothetical protein Nwi_1129 16 None None None 75676093 Common - hypothetical protein Nwi_1902 220 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 75675893 Nonpathogen - hypothetical protein Nwi_1701 9 None None None 75674316 Common - glutathione synthetase Nwi_0117 130 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 75675202 Common - Uncharacterized protein involved in outer membrane biogenesis Nwi_1009 57 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 75676978 Nonpathogen - hypothetical protein Nwi_2794 5 None None None 75675836 Common - Lytic murein transglycosylase Nwi_1644 106 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 75677263 Common - hypothetical protein Nwi_3085 9 None None None 75676335 Common - ribosomal RNA methyltransferase RrmJ/FtsJ Nwi_2150 138 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 75675409 Common - TRAP dicarboxylate transporter- DctP subunit Nwi_1216 88 COG4663 FcbT1, TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 75675651 Common - hypothetical protein Nwi_1459 73 COG1742 COG1742, Uncharacterized conserved protein Function unknown 75676466 Nonpathogen - hypothetical protein Nwi_2281 12 None None None 75675608 Common - hypothetical protein Nwi_1416 15 COG5653 COG5653, Protein involved in cellulose biosynthesis (CelD) Cell envelope biogenesis, outer membrane 75676680 Nonpathogen - hypothetical protein Nwi_2496 2 None None None 75674532 Nonpathogen - hypothetical protein Nwi_0334 7 None None None 75675220 Common - response regulator receiver Nwi_1027 215 COG4566 TtrR, Response regulator Signal transduction mechanisms 75674305 Common - preprotein translocase subunit SecB Nwi_0106 109 COG1952 SecB, Preprotein translocase subunit SecB Intracellular trafficking and secretion 75674349 Common - extracellular solute-binding protein, family 3 Nwi_0150 165 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 75676707 Common - molybdopterin biosynthesis MoaE Nwi_2523 146 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 75675058 Nonpathogen - hypothetical protein Nwi_0863 3 COG3593 COG3593, Predicted ATP-dependent endonuclease of the OLD family DNA replication, recombination, and repair 75676452 Common - Fe-S oxidoreductase Nwi_2267 114 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 75676162 Nonpathogen - hypothetical protein Nwi_1972 1 None None None 75676327 Common - phage integrase Nwi_2142 112 COG0582 XerC, Integrase DNA replication, recombination, and repair 75676005 Common - dihydrolipoamide dehydrogenase Nwi_1813 246 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 75675898 Common - glutathione S-transferase Nwi_1706 102 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 75674838 Common - helix-turn-helix, Fis-type Nwi_0640 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 75676332 Nonpathogen - hypothetical protein Nwi_2147 4 None None None 75674435 Common - H+-transporting two-sector ATPase, B/B' subunit Nwi_0236 31 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 75675797 Common - carboxyl transferase Nwi_1605 143 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 75676933 Nonpathogen - hypothetical protein Nwi_2749 6 COG5509 COG5509, Uncharacterized small protein containing a coiled-coil domain Function unknown 75674755 Common - NnrS Nwi_0557 57 COG3213 NnrS, Uncharacterized protein involved in response to NO Inorganic ion transport and metabolism 75676906 Common - Transcriptional regulatory protein, TetR family Nwi_2722 77 COG1309 AcrR, Transcriptional regulator Transcription 75676397 Common - ABC transporter, ATPase subunit Nwi_2212 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 75676389 Common - molybdopterin dehydrogenase, FAD-binding Nwi_2204 98 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 75677272 Nonpathogen - hypothetical protein Nwi_3094 1 None None None 75674657 Common - hypothetical protein Nwi_0459 51 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 75676777 Common - 4-diphosphocytidyl-2C-methyl-D-erythritol kinase Nwi_2593 175 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 75676217 Common - peptide chain release factor 3 Nwi_2027 249 COG4108 PrfC, Peptide chain release factor RF-3 Translation, ribosomal structure and biogenesis 75675662 Nonpathogen - hypothetical protein Nwi_1470 2 None None None 75675376 Nonpathogen - hypothetical protein Nwi_1183 5 None None None 75674407 Common - cytidylate kinase Nwi_0208 204 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 75675371 Common - Conserved hypothetical protein 2217 Nwi_1178 25 COG5448 COG5448, Uncharacterized conserved protein Function unknown 75676153 Common - hypothetical protein Nwi_1962 3 None None None 75676549 Common - ErfK/YbiS/YcfS/YnhG Nwi_2364 23 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 75675677 Common - Phage portal protein, HK97 Nwi_1485 61 COG4695 COG4695, Phage-related protein Function unknown 75677286 Common - hypothetical protein Nwi_3108 30 COG5483 COG5483, Uncharacterized conserved protein Function unknown