Streptococcus pyogenes MGAS10394, complete genome NC_006086 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 50915180 Common rpmF 50S ribosomal protein L32 M6_Spy1834 55 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 50914864 Common - ABC transporter ATP-binding protein M6_Spy1518 249 COG4988 CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 50914742 Common - hypothetical protein M6_Spy1396 3 None None None 50913651 Common - KtrB M6_Spy0305 97 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 50913699 Common upp uracil phosphoribosyltransferase M6_Spy0353 165 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 50914480 Common - prophage pi2 protein 38 M6_Spy1134 5 None None None 50914208 Common - Phosphinothricin N-acetyltransferase M6_Spy0862 9 COG0456 RimI, Acetyltransferases General function prediction only 50914111 Common - Tetratricopeptide repeat family protein M6_Spy0765 28 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 50913787 Common - Exoribonuclease II M6_Spy0441 192 COG0557 VacB, Exoribonuclease R Transcription 50914891 Pathogen - Holin M6_Spy1545 1 COG5546 COG5546, Small integral membrane protein Function unknown 50914024 Common - 2-dehydropantoate 2-reductase M6_Spy0678 129 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 50914843 Common - Phosphoglycerate mutase M6_Spy1497 44 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 50915066 Common - trans-acting positive regulator M6_Spy1720 7 None None None 50914662 Common - 3-dehydroquinate synthase M6_Spy1316 205 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 50914812 Common - Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) M6_Spy1466 232 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 50913429 Common - Transcriptional regulator M6_Spy0083 1 None None None 50913505 Common - Collagen adhesion protein M6_Spy0159 7 COG4932 COG4932, Predicted outer membrane protein Cell envelope biogenesis, outer membrane 50914273 Common - phosphoglucomutase M6_Spy0927 238 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 50913426 Common - phosphoribosylaminoimidazole carboxylase ATPase subunit M6_Spy0080 193 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 50914031 Pathogen - hypothetical protein M6_Spy0685 1 None None None 50914154 Common uvrC excinuclease ABC subunit C M6_Spy0808 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 50914346 Common - Major tail protein M6_Spy1000 6 None None None 50914627 Pathogen - Prepilin peptidase family M6_Spy1281 1 None None None 50913550 Common - Glycine betaine transport system permease protein M6_Spy0204 175 COG4176 ProW, ABC-type proline/glycine betaine transport system, permease component Amino acid transport and metabolism 50913390 Common - unknown phage protein M6_Spy0044 8 COG5585 COG5585, NAD+--asparagine ADP-ribosyltransferase Signal transduction mechanisms 50914775 Common glpK glycerol kinase M6_Spy1429 179 COG0554 GlpK, Glycerol kinase Energy production and conversion 50913498 Common - Deoxyadenosine kinase M6_Spy0152 39 COG1428 COG1428, Deoxynucleoside kinases Nucleotide transport and metabolism 50913516 Common - Translation initiation inhibitor M6_Spy0170 176 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 50914967 Common - Mechanosensitive ion channel M6_Spy1621 133 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 50914196 Common - Na+ driven multidrug efflux pump M6_Spy0850 2 None None None 50914375 Common - Glycogen phosphorylase M6_Spy1029 146 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 50914400 Common - Beta-glucosidase M6_Spy1054 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 50914756 Common - ATP-dependent RNA helicase M6_Spy1411 239 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 50914762 Pathogen - hypothetical protein M6_Spy1416 1 None None None 50914266 Common - Glycine cleavage system H protein M6_Spy0920 46 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 50914636 Common - asparagine synthetase AsnA M6_Spy1290 31 COG2502 AsnA, Asparagine synthetase A Amino acid transport and metabolism 50915177 Common - Hypothetical membrane spanning protein M6_Spy1831 71 COG1284 COG1284, Uncharacterized conserved protein Function unknown 50914751 Common - Amino acid permease M6_Spy1405 136 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 50914597 Common - Dimethylallyltransferase M6_Spy1251 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 50913533 Pathogen - hypothetical protein M6_Spy0187 1 None None None 50914075 Common - DNA topoisomerase IV subunit A M6_Spy0729 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 50913601 Common - ribosome-associated GTPase M6_Spy0255 163 COG1162 COG1162, Predicted GTPases General function prediction only 50913903 Common - aspartate aminotransferase M6_Spy0557 240 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 50914886 Common - unknown phage protein M6_Spy1540 1 None None None 50914615 Common - Pyridoxal-5'-phosphate family protein M6_Spy1269 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 50913353 Common - Heat shock protein 15 M6_Spy0007 47 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 50914428 Common - S-adenosylmethionine synthetase M6_Spy1082 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 50915100 Common - Translation initiation inhibitor M6_Spy1754 4 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 50914961 Common rpmB 50S ribosomal protein L28 M6_Spy1615 81 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 50915210 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase M6_Spy1864 204 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 50914801 Common - Esterase M6_Spy1455 53 COG0657 Aes, Esterase/lipase Lipid metabolism 50913941 Common - F0F1 ATP synthase subunit delta M6_Spy0595 70 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 50914959 Common - Predicted kinase related to hydroxyacetone kinase M6_Spy1613 50 COG1461 COG1461, Predicted kinase related to dihydroxyacetone kinase General function prediction only 50913606 Common - purine operon repressor M6_Spy0260 97 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 50913582 Common - FasC M6_Spy0236 10 COG2972 COG2972, Predicted signal transduction protein with a C-terminal ATPase domain Signal transduction mechanisms 50915030 Common - Undecaprenyl pyrophosphate synthetase M6_Spy1684 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 50914048 Common - isopentenyl pyrophosphate isomerase M6_Spy0702 83 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 50914081 Common - hypothetical protein M6_Spy0735 5 None None None 50913568 Pathogen - Hypothetical cytosolic protein M6_Spy0222 1 None None None 50914182 Common - Lipase/Acylhydrolase family protein M6_Spy0836 23 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 50914973 Pathogen - hypothetical protein M6_Spy1627 1 None None None 50914172 Common - PotC M6_Spy0826 187 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 50915061 Common - hypothetical protein M6_Spy1715 15 None None None 50914142 Common - GTP-binding protein LepA M6_Spy0796 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 50914692 Pathogen - unknown phage protein M6_Spy1346 1 None None None 50913876 Common tpiA triosephosphate isomerase M6_Spy0530 216 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 50914957 Common - Acid phosphatase M6_Spy1611 28 COG2503 COG2503, Predicted secreted acid phosphatase General function prediction only 50915016 Common ulaA ascorbate-specific PTS system enzyme IIC M6_Spy1670 36 COG3037 SgaT, Uncharacterized protein conserved in bacteria Function unknown 50914656 Common valS valyl-tRNA synthetase M6_Spy1310 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 50915013 Common - hypothetical protein M6_Spy1667 2 None None None 50914670 Common - Two-component sensor kinase yesM M6_Spy1324 101 COG2972 COG2972, Predicted signal transduction protein with a C-terminal ATPase domain Signal transduction mechanisms 50913733 Common - Phosphohydrolase (MutT/nudix family protein) M6_Spy0387 119 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 50914916 Common - Transcriptional regulator M6_Spy1570 4 None None None 50915038 Pathogen - Streptokinase M6_Spy1692 1 None None None 50914931 Common - Aquaporin M6_Spy1585 132 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 50913758 Common - Uracil DNA glycosylase superfamily protein M6_Spy0412 56 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 50913434 Common - Acetaldehyde dehydrogenase [acetylating] M6_Spy0088 186 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 50913811 Pathogen - hypothetical protein M6_Spy0465 1 None None None 50913706 Common - DNA replication intiation control protein YabA M6_Spy0360 15 COG4467 COG4467, Uncharacterized protein conserved in bacteria Function unknown 50914677 Common - Beta-glucosidase M6_Spy1331 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 50915045 Common - Hypothetical cytosolic protein M6_Spy1699 140 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 50914162 Common - Polysaccharide deacetylase M6_Spy0816 85 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 161761310 Common rpsT 30S ribosomal protein S20 M6_Spy0935 154 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 50914735 Common - Transcriptional regulators, LysR family M6_Spy1389 176 COG0583 LysR, Transcriptional regulator Transcription 50914524 Common - Hypothetical protein with endo/excinuclease domain M6_Spy1178 71 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 50914296 Common - bifunctional riboflavin kinase/FMN adenylyltransferase M6_Spy0950 211 COG0196 RibF, FAD synthase Coenzyme metabolism 50913410 Pathogen - Holin M6_Spy0064 1 COG5546 COG5546, Small integral membrane protein Function unknown 50914897 Common - Phage endopeptidase M6_Spy1551 7 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 161761323 Common - putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein M6_Spy0330 235 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 50914856 Pathogen - ABC transporter permease protein M6_Spy1510 1 None None None 50914820 Common - PTS system, mannose-specific IIC component M6_Spy1474 35 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 50915097 Common secE preprotein translocase subunit SecE M6_Spy1751 2 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 50914435 Common - Hypothetical Membrane Spanning Protein M6_Spy1089 3 COG3326 COG3326, Predicted membrane protein Function unknown 50914147 Common - PTS system, mannose/fructose family IIB component M6_Spy0801 40 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 50914519 Common - LPXTG anchored putative adhesin M6_Spy1173 40 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 161761306 Common - transketolase M6_Spy1423 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 50915090 Common - PTS system, cellobiose-specific IIC component M6_Spy1744 38 COG1455 CelB, Phosphotransferase system cellobiose-specific component IIC Carbohydrate transport and metabolism 50914041 Common - 5'-nucleotidase M6_Spy0695 115 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 161761300 Common rplM 50S ribosomal protein L13 M6_Spy1655 220 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 50913690 Common - Pyruvate formate-lyase activating enzyme M6_Spy0344 74 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 50913827 Common - Glycosyltransferase M6_Spy0481 15 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 50913438 Common rpsJ 30S ribosomal protein S10 M6_Spy0092 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 50913896 Common - iron-sulfur cluster-binding protein M6_Spy0550 138 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 50913619 Common - ABC transporter ATP-binding protein M6_Spy0273 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 50913610 Common - elongation factor G M6_Spy0264 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 50915050 Common - anthranilate synthase component II M6_Spy1704 240 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 50913670 Common - Acylphosphatase M6_Spy0324 37 COG1254 AcyP, Acylphosphatases Energy production and conversion 50914983 Common - ABC transporter ATP-binding protein M6_Spy1637 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 50915172 Common - ArgR M6_Spy1826 81 COG1438 ArgR, Arginine repressor Transcription 50913372 Pathogen - unknown phage protein M6_Spy0026 1 None None None 50913641 Common - Hypothetical cytosolic protein M6_Spy0295 26 COG1323 COG1323, Predicted nucleotidyltransferase General function prediction only 50913923 Common - Enolase M6_Spy0577 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 50915150 Common - DNA integration/recombination/invertion protein M6_Spy1804 182 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 50913997 Common rplU 50S ribosomal protein L21 M6_Spy0651 131 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 50913722 Pathogen - C3 family ADP-ribosyltransferase M6_Spy0376 1 COG5585 COG5585, NAD+--asparagine ADP-ribosyltransferase Signal transduction mechanisms 50915085 Common - Streptodornase M6_Spy1739 4 None None None 50915162 Common - unknown phage protein M6_Spy1816 6 None None None 50913444 Common rplV 50S ribosomal protein L22 M6_Spy0098 235 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 50914914 Pathogen - hypothetical protein M6_Spy1568 1 None None None 50914720 Common - Xaa-Pro dipeptidase M6_Spy1374 133 COG1739 COG1739, Uncharacterized conserved protein Function unknown 50913712 Common - L-lactate oxidase M6_Spy0366 112 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 50914405 Common - Transposase M6_Spy1059 21 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 50913906 Common - Hypothetical cytosolic protein M6_Spy0560 91 COG0391 COG0391, Uncharacterized conserved protein Function unknown 50914498 Common - unknown phage protein M6_Spy1152 8 None None None 50914990 Common - tagatose 1,6-diphosphate aldolase M6_Spy1644 26 COG3684 LacD, Tagatose-1,6-bisphosphate aldolase Carbohydrate transport and metabolism 50913898 Common - Cell division ATP-binding protein M6_Spy0552 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 50913963 Common - RNA polymerase sigma factor RpoD M6_Spy0617 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 50913893 Common - 2-dehydro-3-deoxygluconokinase M6_Spy0547 75 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 50913830 Common - Macrolide-efflux protein M6_Spy0484 83 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 50913546 Pathogen - hypothetical protein M6_Spy0200 1 None None None 50913756 Common - Myosin-crossreactive antigen M6_Spy0410 25 COG4716 COG4716, Myosin-crossreactive antigen Function unknown 50915140 Common - Hypothetical cytosolic protein M6_Spy1794 13 COG3906 COG3906, Uncharacterized protein conserved in bacteria Function unknown 50914250 Common - signal recognition particle subunit FFH M6_Spy0904 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 50914874 Common - Mannose-6-phosphate isomerase M6_Spy1528 51 COG1482 ManA, Phosphomannose isomerase Carbohydrate transport and metabolism 50915215 Common - Hyaluronan synthase M6_Spy1869 106 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 50914793 Common - galactose-6-phosphate isomerase subunit LacA M6_Spy1447 123 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 50914907 Common - Terminase large subunit M6_Spy1561 15 COG1783 XtmB, Phage terminase large subunit General function prediction only 50914333 Common - hypothetical protein M6_Spy0987 14 None None None 50914469 Common - hypothetical protein M6_Spy1123 3 None None None 50913466 Common rplQ 50S ribosomal protein L17 M6_Spy0120 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 50913803 Common - ABC transporter permease protein M6_Spy0457 28 COG3694 COG3694, ABC-type uncharacterized transport system, permease component General function prediction only 50913561 Common - Peptidoglycan endo-beta-N-acetylglucosaminidase M6_Spy0215 7 COG5279 CYK3, Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain Cell division and chromosome partitioning 50914301 Common - ABC transporter permease protein M6_Spy0955 37 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 50913866 Common - Thiamine transporter M6_Spy0520 13 COG3859 COG3859, Predicted membrane protein Function unknown 50914753 Common - Hypothetical membrane associated protein M6_Spy1407 2 None None None 50914575 Pathogen - unknown phage protein M6_Spy1229 1 None None None 50914479 Common - prophage pi2 protein 39 M6_Spy1133 5 None None None 50913450 Common rplX 50S ribosomal protein L24 M6_Spy0104 213 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 50915148 Common - Multidrug resistance protein B M6_Spy1802 62 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 50915073 Common - ABC transporter ATP-binding protein M6_Spy1727 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 50914490 Common - Adenine-specific methyltransferase M6_Spy1144 105 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 50915092 Common - PTS system, cellobiose-specific IIA component M6_Spy1746 32 COG1447 CelC, Phosphotransferase system cellobiose-specific component IIA Carbohydrate transport and metabolism 50913555 Pathogen - hypothetical protein M6_Spy0209 1 None None None 50915099 Common - Multimodular transpeptidase-transglycosylase PBP 2A M6_Spy1753 205 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 50914529 Common - Hypothetical Membrane Spanning Protein M6_Spy1183 3 COG5522 COG5522, Predicted integral membrane protein Function unknown 50914137 Common - acyl-acyl carrier protein thioesterase M6_Spy0791 19 COG3884 FatA, Acyl-ACP thioesterase Lipid metabolism 50913396 Pathogen - unknown phage protein M6_Spy0050 1 None None None 50914078 Common rpsA 30S ribosomal protein S1 M6_Spy0732 226 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 50913476 Common - Multimodular transpeptidase-transglycosylase M6_Spy0130 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 50913593 Common - N-acetylneuraminate transport system permease protein M6_Spy0247 158 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 50913727 Pathogen - hypothetical protein M6_Spy0381 1 None None None 50914880 Common nusB transcription antitermination protein NusB M6_Spy1534 85 COG0781 NusB, Transcription termination factor Transcription 50914659 Common - Hypothetical cytosolic protein M6_Spy1313 1 None None None 50914644 Common - Arginine repressor, argR M6_Spy1298 57 COG1438 ArgR, Arginine repressor Transcription 50914097 Common - ribonuclease Z M6_Spy0751 105 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 50914654 Pathogen - hypothetical protein M6_Spy1308 1 None None None 50913680 Common scpA segregation and condensation protein A M6_Spy0334 138 COG1354 COG1354, Uncharacterized conserved protein Function unknown 50913578 Common - Carbonic anhydrase M6_Spy0232 58 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 50914777 Common - hypothetical protein M6_Spy1431 15 COG4224 COG4224, Uncharacterized protein conserved in bacteria Function unknown 50913768 Common - Bacteriocin M6_Spy0422 2 None None None 50913613 Common - Amino acid transport ATP-binding protein M6_Spy0267 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 50914562 Common - unknown phage protein M6_Spy1216 2 None None None 50913529 Common - adenylosuccinate synthetase M6_Spy0183 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 50914302 Common - ABC transporter ATP-binding protein M6_Spy0956 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 50913761 Common era GTP-binding protein Era M6_Spy0415 229 COG1159 Era, GTPase General function prediction only 50914320 Common - Signal peptidase I M6_Spy0974 54 None None None 50913717 Pathogen - hypothetical protein M6_Spy0371 1 None None None 50914067 Common pyrE orotate phosphoribosyltransferase M6_Spy0721 157 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 50913576 Common dut deoxyuridine 5'-triphosphate nucleotidohydrolase M6_Spy0230 175 COG0756 Dut, dUTPase Nucleotide transport and metabolism 50914749 Common nadE NAD synthetase M6_Spy1403 131 COG0171 NadE, NAD synthase Coenzyme metabolism 50913485 Common - ComG operon protein 6 M6_Spy0139 4 COG4940 ComGF, Competence protein ComGF Intracellular trafficking and secretion 50913535 Pathogen - hypothetical protein M6_Spy0189 1 None None None 161761325 Common - V-type ATP synthase subunit K M6_Spy0174 17 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 50914366 Pathogen - unknown phage protein M6_Spy1020 1 None None None 50914921 Common - Hypothetical cytosolic protein M6_Spy1575 2 None None None 50914607 Common - ATP-dependent clp protease ATP-binding subunit M6_Spy1261 219 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 50914186 Common - redox-sensing transcriptional repressor Rex M6_Spy0840 56 COG2344 COG2344, AT-rich DNA-binding protein General function prediction only 50914556 Pathogen - unknown phage protein M6_Spy1210 1 None None None 50913940 Common - F0F1 ATP synthase subunit B M6_Spy0594 145 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 50914244 Common - oxaloacetate decarboxylase M6_Spy0898 175 COG5016 COG5016, Pyruvate/oxaloacetate carboxyltransferase Energy production and conversion 50914825 Common - acetyl-CoA carboxylase subunit beta M6_Spy1479 218 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 50914502 Pathogen - hypothetical protein M6_Spy1156 1 None None None 50914101 Common - DNA replication protein M6_Spy0755 19 COG3935 DnaD, Putative primosome component and related proteins DNA replication, recombination, and repair 50915122 Common - Formiminoglutamase M6_Spy1776 135 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 161761313 Common rplJ 50S ribosomal protein L10 M6_Spy0813 215 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 50914361 Pathogen - unknown phage protein M6_Spy1015 1 None None None 50914838 Common dnaK molecular chaperone DnaK M6_Spy1492 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 50914740 Common - D-beta-hydroxybutyrate permease M6_Spy1394 37 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 50913664 Common murC UDP-N-acetylmuramate--L-alanine ligase M6_Spy0318 211 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 50914001 Common - Lipoprotein signal peptidase M6_Spy0655 136 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 50914683 Common - tRNA (Uracil-5-) -methyltransferase M6_Spy1337 197 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 50915164 Pathogen - unknown phage protein M6_Spy1818 1 None None None 50913814 Common - Hypothetical cytosolic protein M6_Spy0468 4 None None None 50913855 Common - hypothetical protein M6_Spy0509 11 COG4768 COG4768, Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain General function prediction only 50914220 Pathogen - hypothetical protein M6_Spy0874 1 None None None 50914457 Common - Oligoendopeptidase F M6_Spy1111 85 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 50913947 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase M6_Spy0601 212 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 50914570 Pathogen - unknown phage protein M6_Spy1224 1 None None None 50914919 Common - MutS M6_Spy1573 205 COG1193 COG1193, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 50914152 Common - Iron(III)-binding protein M6_Spy0806 77 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 50915127 Common - Neutral endopeptidase M6_Spy1781 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 50914516 Pathogen - hypothetical protein M6_Spy1170 1 None None None 50914354 Common - Portal protein M6_Spy1008 27 COG4695 COG4695, Phage-related protein Function unknown 50914105 Common - Glycine/D-amino acid oxidase family M6_Spy0759 98 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 50913952 Common - Salt-stress induced protein M6_Spy0606 1 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 50914257 Common - Hypothetical membrane spanning protein M6_Spy0911 7 COG4720 COG4720, Predicted membrane protein Function unknown 50914706 Pathogen - unknown phage protein M6_Spy1360 2 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 50914545 Common - Holin M6_Spy1199 4 COG4824 COG4824, Phage-related holin (Lysis protein) General function prediction only 50914567 Pathogen - unknown phage protein M6_Spy1221 1 None None None 50913365 Common recO DNA repair protein RecO M6_Spy0019 34 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 50914393 Pathogen - hypothetical protein M6_Spy1047 1 None None None 50914462 Common - Hypothetical cytosolic protein M6_Spy1116 4 None None None 50914701 Pathogen - Minor capsid protein M6_Spy1355 1 None None None 50914061 Common - purine nucleoside phosphorylase M6_Spy0715 133 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 50914170 Common - PotA M6_Spy0824 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 50915116 Common - formiminotetrahydrofolate cyclodeaminase M6_Spy1770 36 COG3404 COG3404, Methenyl tetrahydrofolate cyclohydrolase Amino acid transport and metabolism 50914225 Common rnhB ribonuclease HII M6_Spy0879 231 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 50914925 Pathogen - hypothetical protein M6_Spy1579 1 None None None 50914558 Pathogen - unknown phage protein M6_Spy1212 1 None None None 50913392 Pathogen - unknown phage protein M6_Spy0046 1 None None None 50913661 Common engA GTP-binding protein EngA M6_Spy0315 231 COG1160 COG1160, Predicted GTPases General function prediction only 50913805 Common - Dihydroxyacetone kinase M6_Spy0459 77 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 50913399 Pathogen - unknown phage protein M6_Spy0053 2 None None None 50914268 Common - Probable NADH-dependent flavin oxidoreductase M6_Spy0922 177 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 50914287 Common - Phosphate transport ATP-binding protein pstB M6_Spy0941 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 50914862 Common - membrane-bound protein M6_Spy1516 9 None None None 50914888 Common - MF3 M6_Spy1542 17 None None None 50913738 Common - Manganese-binding protein M6_Spy0392 179 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 50914764 Common proA gamma-glutamyl phosphate reductase M6_Spy1418 193 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 50914595 Common - Arginine repressor M6_Spy1249 15 COG1438 ArgR, Arginine repressor Transcription 161761295 Common hisS histidyl-tRNA synthetase M6_Spy1833 248 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 50913514 Common - Acetate CoA-transferase beta subunit M6_Spy0168 107 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 50914063 Pathogen - Histidine protein kinase M6_Spy0717 1 None None None 50914166 Common - Dihydropteroate synthase M6_Spy0820 219 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 50914733 Common gmk guanylate kinase M6_Spy1387 214 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 50913871 Common - Oligoendopeptidase F M6_Spy0525 84 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 50914512 Common - Macrolide-efflux protein M6_Spy1166 156 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 50914893 Pathogen - unknown phage protein M6_Spy1547 1 None None None 50914787 Common - Transcriptional regulator, TetR family M6_Spy1441 7 COG1309 AcrR, Transcriptional regulator Transcription 50914038 Common - ABC transporter ATP-binding protein M6_Spy0692 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 50914486 Common - Portal protein M6_Spy1140 71 COG4695 COG4695, Phage-related protein Function unknown 50913376 Pathogen - unknown phage protein M6_Spy0030 1 None None None 50914744 Common - Cell division initiation protein M6_Spy1398 12 COG3599 DivIVA, Cell division initiation protein Cell division and chromosome partitioning 50913720 Common - ribonucleotide-diphosphate reductase subunit alpha M6_Spy0374 221 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 50914092 Common - putative exfoliative toxin M6_Spy0746 11 COG1275 TehA, Tellurite resistance protein and related permeases Inorganic ion transport and metabolism 50914810 Common - EcsB M6_Spy1464 12 COG4473 EcsB, Predicted ABC-type exoprotein transport system, permease component Intracellular trafficking and secretion 50913617 Common - adaptor protein M6_Spy0271 13 COG4862 MecA, Negative regulator of genetic competence, sporulation and motility Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion 50914869 Common - Immunogenic secreted protein M6_Spy1523 9 COG3942 COG3942, Surface antigen General function prediction only 50914455 Common - O-methyltransferase M6_Spy1109 104 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 50914231 Common - Biotin carboxyl carrier protein of oxaloacetate decarboxylase M6_Spy0885 191 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 50914198 Common - Glycine betaine transport system permease protein M6_Spy0852 157 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 50913775 Pathogen - hypothetical protein M6_Spy0429 1 None None None 50914387 Common - D-alanine--poly(phosphoribitol) ligase subunit 2 M6_Spy1041 12 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 50914146 Common - PTS system, mannose/fructose family IIA component M6_Spy0800 8 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 50913887 Common - PTS system, N-acetylgalactosamine-specific IIC component M6_Spy0541 36 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 50914397 Common - PTS system, cellobiose-specific IIB component M6_Spy1051 29 COG1440 CelA, Phosphotransferase system cellobiose-specific component IIB Carbohydrate transport and metabolism 50915182 Common - Cadmium resistance protein M6_Spy1836 19 COG4300 CadD, Predicted permease, cadmium resistance protein Inorganic ion transport and metabolism 50914536 Common - phosphoglyceromutase M6_Spy1190 158 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 50914348 Common - unknown phage protein M6_Spy1002 2 None None None 50914058 Common - ribose-5-phosphate isomerase A M6_Spy0712 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 50915043 Common - Exodeoxyribonuclease III M6_Spy1697 5 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 50913689 Common - Magnesium and cobalt efflux protein M6_Spy0343 219 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 50913419 Common - amidophosphoribosyltransferase M6_Spy0073 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 50914270 Common - phosphopantothenate--cysteine ligase M6_Spy0924 194 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 50914408 Common - malonate permease M6_Spy1062 20 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 50914905 Common - unknown phage protein M6_Spy1559 7 COG5585 COG5585, NAD+--asparagine ADP-ribosyltransferase Signal transduction mechanisms 50913794 Common - Lactoylglutathione lyase M6_Spy0448 125 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 50914981 Common - Sensory transduction protein kinase M6_Spy1635 13 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 50914123 Common - Pyruvate dehydrogenase E1 component beta subunit M6_Spy0777 218 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 50914188 Common - Cysteine desulfhydrase M6_Spy0842 240 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 50914876 Pathogen - Endo-beta-N-acetylglucosaminidase F2 precursor M6_Spy1530 3 None None None 50914613 Common - Integral membrane protein M6_Spy1267 17 COG0762 COG0762, Predicted integral membrane protein Function unknown 50914323 Common dnaE DNA polymerase III DnaE M6_Spy0977 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 50914804 Common - hypothetical protein M6_Spy1458 22 COG1358 RPL8A, Ribosomal protein HS6-type (S12/L30/L7a) Translation, ribosomal structure and biogenesis 50913731 Common - Phosphoglycerate transporter protein M6_Spy0385 58 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 50914019 Common - Transcriptional regulator, TetR family M6_Spy0673 17 COG1309 AcrR, Transcriptional regulator Transcription 50914989 Common - PTS system, lactose-specific IIA component M6_Spy1643 32 COG1447 CelC, Phosphotransferase system cellobiose-specific component IIA Carbohydrate transport and metabolism 50914975 Common - Type I restriction-modification system restriction subunit M6_Spy1629 139 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 50913657 Common - Transmembrane histidine kinase CsrS M6_Spy0311 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 50915202 Common - tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA M6_Spy1856 191 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 50913883 Common - Calcium-transporting ATPase M6_Spy0537 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 50913358 Common - hypoxanthine-guanine phosphoribosyltransferase M6_Spy0012 155 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 50914179 Common - Zn-dependent alcohol dehydrogenase and related dehydrogenase M6_Spy0833 207 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 50913530 Common - Nucleoside-binding protein M6_Spy0184 94 COG1744 Med, Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein General function prediction only 50913894 Common - keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase M6_Spy0548 126 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 50915021 Pathogen - hypothetical protein M6_Spy1675 1 None None None 50914997 Pathogen - DNA integration/recombination/invertion protein M6_Spy1651 1 None None None 50914908 Common - DNA integration/recombination/invertion protein M6_Spy1562 77 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 50913966 Common - alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase M6_Spy0620 27 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 50913479 Common - Putative DNA binding protein M6_Spy0133 5 COG4699 COG4699, Uncharacterized protein conserved in bacteria Function unknown 50914934 Common - x-prolyl-dipeptidyl aminopeptidase M6_Spy1588 12 COG2936 COG2936, Predicted acyl esterases General function prediction only 50913544 Common - putative L-xylulose 5-phosphate 3-epimerase M6_Spy0198 34 COG3623 SgaU, Putative L-xylulose-5-phosphate 3-epimerase Carbohydrate transport and metabolism 50914590 Common - Hypothetical membrane associated protein M6_Spy1244 11 COG4698 COG4698, Uncharacterized protein conserved in bacteria Function unknown 50913843 Common - Multidrug resistance protein B M6_Spy0497 194 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 50913710 Common - Arsenate reductase family protein M6_Spy0364 70 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 50914503 Pathogen - hypothetical protein M6_Spy1157 1 None None None 50913646 Common - ABC transporter ATP-binding protein M6_Spy0300 249 COG1135 AbcC, ABC-type metal ion transport system, ATPase component Inorganic ion transport and metabolism 50915129 Common - PTS system, trehalose-specific IIBC component M6_Spy1783 60 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 50913580 Common gltX glutamyl-tRNA synthetase M6_Spy0234 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 50913979 Common - Ferredoxin M6_Spy0633 3 COG1141 Fer, Ferredoxin Energy production and conversion 50914218 Common - Lactoylglutathione lyase M6_Spy0872 42 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 50915011 Pathogen - Hypothetical cytosolic protein M6_Spy1665 1 None None None 50915217 Common - UTP--glucose-1-phosphate uridylyltransferase M6_Spy1871 232 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 50914275 Common - Nucleoside transport system permease protein M6_Spy0929 106 COG4603 COG4603, ABC-type uncharacterized transport system, permease component General function prediction only 50914116 Common - ABC transporter permease protein M6_Spy0770 95 COG4120 COG4120, ABC-type uncharacterized transport system, permease component General function prediction only 50913813 Common - Long-chain-fatty-acid--CoA ligase M6_Spy0467 39 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 50915020 Common rpsO 30S ribosomal protein S15 M6_Spy1674 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 50914633 Common - ATP-dependent protease La M6_Spy1287 41 COG3480 SdrC, Predicted secreted protein containing a PDZ domain Signal transduction mechanisms 50914955 Common - hypothetical protein M6_Spy1609 4 COG4129 COG4129, Predicted membrane protein Function unknown 50914334 Common - Phage-associated cell wall hydrolase M6_Spy0988 67 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 50914174 Common - DpiA M6_Spy0828 45 COG4565 CitB, Response regulator of citrate/malate metabolism Transcription / Signal transduction mechanisms 50915089 Common - Formate acetyltransferase M6_Spy1743 59 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 50914083 Common - Phage transcriptional repressor M6_Spy0737 22 COG2932 COG2932, Predicted transcriptional regulator Transcription 50913677 Common - putative phosphoesterase M6_Spy0331 40 COG0622 COG0622, Predicted phosphoesterase General function prediction only 50914140 Pathogen - Nucleoside diphosphate kinase M6_Spy0794 1 None None None 50913381 Common - virulence-associated protein E M6_Spy0035 55 COG3378 COG3378, Predicted ATPase General function prediction only 50913669 Common - OxaA-like protein precursor M6_Spy0323 11 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 50914933 Common - Transcription regulator, crp family M6_Spy1587 12 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 50913549 Common - Glycine betaine transport ATP-binding protein M6_Spy0203 249 COG4175 ProV, ABC-type proline/glycine betaine transport system, ATPase component Amino acid transport and metabolism 50914658 Pathogen - Ribosomal-protein-serine acetyltransferase M6_Spy1312 2 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 50913990 Common - glutathione reductase M6_Spy0644 244 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 50915209 Common - Cobalt transport ATP-binding protein cbiO M6_Spy1863 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 50913526 Common - V-type ATP synthase subunit D M6_Spy0180 41 COG1394 NtpD, Archaeal/vacuolar-type H+-ATPase subunit D Energy production and conversion 50914694 Pathogen - Hyaluronoglucosaminidase M6_Spy1348 1 None None None 50914850 Common - Nicotinamidase M6_Spy1504 110 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 50914012 Common - Glycerophosphoryl diester phosphodiesterase M6_Spy0666 91 COG4781 COG4781, Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase Energy production and conversion 50914297 Common truB tRNA pseudouridine synthase B M6_Spy0951 245 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 50914357 Common - Terminase large subunit M6_Spy1011 46 COG4626 COG4626, Phage terminase-like protein, large subunit General function prediction only 50914026 Common - 1-phosphofructokinase M6_Spy0680 111 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 50913693 Common - FhuG M6_Spy0347 190 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 50913469 Common - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase M6_Spy0123 186 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 50914945 Common - Uridine phosphorylase M6_Spy1599 100 COG2820 Udp, Uridine phosphorylase Nucleotide transport and metabolism 50913639 Common - iojap protein family M6_Spy0293 181 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 50913662 Common - SWF/SNF family helicase M6_Spy0316 142 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 50914791 Common - Tagatose-6-phosphate kinase M6_Spy1445 25 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 50914118 Common - Zn-dependent hydrolase M6_Spy0772 159 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 50913563 Pathogen - Enterotoxin M6_Spy0217 2 None None None 50913574 Common - Multidrug resistance ABC transporter ATP-binding and permease protein M6_Spy0228 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 50915207 Common - Cobalt transport protein cbiQ M6_Spy1861 97 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 50914807 Common - hypothetical protein M6_Spy1461 145 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 50913889 Common - Unsaturated glucuronyl hydrolase M6_Spy0543 21 COG4225 COG4225, Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins General function prediction only 50914882 Common - elongation factor P M6_Spy1536 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 50913864 Common - Phosphoglycerate mutase M6_Spy0518 145 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 50914477 Common - unknown phage protein M6_Spy1131 2 None None None 50915075 Pathogen - hypothetical protein M6_Spy1729 1 None None None 50913483 Common - ComG operon protein 4 M6_Spy0137 2 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 50914727 Common - Serine/threonine protein kinase M6_Spy1381 159 COG2815 COG2815, Uncharacterized protein conserved in bacteria Function unknown 50913388 Common - Terminase large subunit M6_Spy0042 28 COG1783 XtmB, Phage terminase large subunit General function prediction only 50913377 Pathogen - unknown phage protein M6_Spy0031 1 None None None 50915094 Common - Transcriptional regulator, DeoR family M6_Spy1748 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 50914527 Common prfC peptide chain release factor 3 M6_Spy1182 249 COG4108 PrfC, Peptide chain release factor RF-3 Translation, ribosomal structure and biogenesis 50913764 Pathogen - hypothetical protein M6_Spy0418 1 None None None 50913491 Common - Glutamyl aminopeptidase M6_Spy0145 79 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 50914450 Common - CAAX amino terminal protease family M6_Spy1104 32 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 50914551 Common - unknown phage protein M6_Spy1205 2 COG4722 COG4722, Phage-related protein Function unknown 50914857 Common - ABC transporter ATP-binding protein M6_Spy1511 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 50914602 Common - Deoxyribodipyrimidine photolyase M6_Spy1256 42 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 50914426 Common - Transposase M6_Spy1080 53 COG3666 COG3666, Transposase and inactivated derivatives DNA replication, recombination, and repair 50913921 Common - Hypothetical cytosolic protein M6_Spy0575 6 COG5506 COG5506, Uncharacterized conserved protein Function unknown 50913370 Common - unknown phage protein M6_Spy0024 2 None None None 50913983 Common rpmI 50S ribosomal protein L35 M6_Spy0637 118 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 50913845 Common - PTS system, beta-glucoside-specific IIABC component M6_Spy0499 60 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 50914460 Common - Glucosamine-6-phosphate isomerase M6_Spy1114 83 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 50913643 Common - hypothetical protein M6_Spy0297 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 50914534 Common - hypothetical protein M6_Spy1188 4 None None None 50915142 Common - hypothetical protein M6_Spy1796 24 COG4472 COG4472, Uncharacterized protein conserved in bacteria Function unknown 50913404 Common - Phage endopeptidase M6_Spy0058 4 None None None 50913995 Common - Capsule biosynthesis protein M6_Spy0649 62 COG2843 PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) Cell envelope biogenesis, outer membrane 50913911 Common - Galactosamine-6-phosphate deaminase (isomerizing) M6_Spy0565 32 COG2222 AgaS, Predicted phosphosugar isomerases Cell envelope biogenesis, outer membrane 50915152 Common - Transcriptional regulator, Cro/CI family M6_Spy1806 8 COG3655 COG3655, Predicted transcriptional regulator Transcription 50914522 Common - 1-acyl-sn-glycerol-3-phosphate acyltransferase M6_Spy1177 56 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 50914466 Common - Superoxide dismutase M6_Spy1120 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 50913891 Common - gluconate 5-dehydrogenase M6_Spy0545 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 50913832 Common - Chromosome segregation ATPase M6_Spy0486 6 COG5293 COG5293, Uncharacterized protein conserved in bacteria Function unknown 50914395 Pathogen - hypothetical protein M6_Spy1049 1 None None None 50914308 Common - General stress protein, Gls24 family M6_Spy0962 37 COG1302 COG1302, Uncharacterized protein conserved in bacteria Function unknown 50914103 Common - Hypothetical cytosolic protein M6_Spy0757 31 COG2384 COG2384, Predicted SAM-dependent methyltransferase General function prediction only 50914621 Common - Hypothetical membrane spanning protein M6_Spy1275 1 None None None 50914433 Common - GAF domain-containing proteins M6_Spy1087 84 COG1956 COG1956, GAF domain-containing protein Signal transduction mechanisms 50915007 Pathogen - Hypothetical membrane associated protein M6_Spy1661 1 None None None 50913869 Common - hypothetical protein M6_Spy0523 4 None None None 50914496 Common - hypothetical protein M6_Spy1150 15 None None None 50914977 Common - Type I restriction-modification system methylation subunit M6_Spy1631 162 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 50914364 Pathogen - unknown phage protein M6_Spy1018 1 None None None 50913819 Common - Chromosome partition protein smc M6_Spy0473 225 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 50914913 Common rpsF 30S ribosomal protein S6 M6_Spy1567 188 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 50915080 Pathogen - Streptopain precursor fragment M6_Spy1734 1 None None None 50914581 Pathogen - unknown phage protein M6_Spy1235 1 None None None 50914495 Common - Phage-related DNA helicase M6_Spy1149 96 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 50914448 Common - Transposase M6_Spy1102 72 None None None 50913626 Common - OppA M6_Spy0280 137 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 50914314 Common - Na(+)-linked D-alanine glycine permease M6_Spy0967 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 50914540 Common - unknown phage protein M6_Spy1194 1 None None None 161761311 Common - acetyl-CoA carboxylase biotin carboxyl carrier protein subunit M6_Spy0891 186 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 50914798 Pathogen - Copper chaperone M6_Spy1452 1 None None None 50914027 Common - PTS system, fructose-specific IIABC component M6_Spy0681 141 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 50913630 Common - OppF M6_Spy0284 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 50915135 Common - Acetyltransferase M6_Spy1789 23 COG3981 COG3981, Predicted acetyltransferase General function prediction only 50913452 Common rpsN 30S ribosomal protein S14 M6_Spy0106 196 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 50914831 Common - acyl-carrier-protein S-malonyltransferase M6_Spy1485 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 50914090 Pathogen - hypothetical protein M6_Spy0744 1 None None None 50913363 Common - Secreted protein M6_Spy0017 12 COG3883 COG3883, Uncharacterized protein conserved in bacteria Function unknown 50913397 Common - unknown phage protein M6_Spy0051 4 None None None 50913433 Common - Acyltransferase family M6_Spy0087 100 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 50915200 Common rplI 50S ribosomal protein L9 M6_Spy1854 164 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 50914416 Common - 23S rRNA m(5)U 1939 methyltransferase M6_Spy1070 197 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 50914584 Pathogen - unknown phage protein M6_Spy1238 1 None None None 50915166 Common - unknown phage protein M6_Spy1820 1 None None None 50914470 Common - Site-specific recombinase M6_Spy1124 112 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 50914780 Common - Hypothetical membrane spanning protein M6_Spy1434 15 COG1755 COG1755, Uncharacterized protein conserved in bacteria Function unknown 50913773 Pathogen - hypothetical protein M6_Spy0427 1 None None None 50915087 Common gldA glycerol dehydrogenase M6_Spy1741 149 COG0371 GldA, Glycerol dehydrogenase and related enzymes Energy production and conversion 50914770 Common - putative translaldolase M6_Spy1424 164 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 50913970 Common - Glycosyltransferase M6_Spy0624 132 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 50915058 Common - Dipeptide transport system permease protein dppC M6_Spy1712 221 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 50914508 Common - ImpB/MucB/SamB family protein M6_Spy1162 168 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 50914518 Common - Zinc-finger protein M6_Spy1172 2 None None None 50913927 Common - Streptolysin S biosynthesis protein M6_Spy0581 12 COG1944 COG1944, Uncharacterized conserved protein Function unknown 50914259 Common - Transcriptional regulator, GntR family M6_Spy0913 162 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 50915114 Common - urocanate hydratase M6_Spy1768 97 COG2987 HutU, Urocanate hydratase Amino acid transport and metabolism 50914569 Common - unknown phage protein M6_Spy1223 2 None None None 50913930 Common - SagG M6_Spy0584 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 50914719 Common - ComF operon protein 1 M6_Spy1373 37 COG4098 comFA, Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) DNA replication, recombination, and repair 50914252 Common - Transcriptional regulator, GntR family M6_Spy0906 130 COG2188 PhnF, Transcriptional regulators Transcription 50913725 Pathogen - hypothetical protein M6_Spy0379 1 None None None 50915220 Common - Glucose uptake protein homolog M6_Spy1874 11 COG4975 GlcU, Putative glucose uptake permease Carbohydrate transport and metabolism 50914686 Common - unknown phage protein M6_Spy1340 7 None None None 50913937 Common - putative lipid kinase M6_Spy0591 110 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 50913687 Common - Fe-S oxidoreductase M6_Spy0341 71 COG1242 COG1242, Predicted Fe-S oxidoreductase General function prediction only 50913633 Common - Competence-specific sigma factor M6_Spy0287 4 None None None 50914779 Common glyQ glycyl-tRNA synthetase subunit alpha M6_Spy1433 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 50914377 Common - Transcriptional regulator, LacI family M6_Spy1031 127 COG1609 PurR, Transcriptional regulators Transcription 50914342 Common - unknown phage protein M6_Spy0996 7 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 50913621 Common - Cysteine desulfhydrase M6_Spy0275 239 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 50914609 Common - Hypothetical cytosolic protein M6_Spy1263 3 None None None 50914927 Common - Formate acetyltransferase M6_Spy1581 55 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 50915225 Common - ABC transporter ATP-binding protein M6_Spy1879 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 50914135 Pathogen - hypothetical protein M6_Spy0789 1 None None None 50914329 Pathogen - SpeK M6_Spy0983 1 None None None 50914668 Common - Beta-galactosidase M6_Spy1322 70 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 50914563 Common - Phage terminase M6_Spy1217 5 COG4626 COG4626, Phage terminase-like protein, large subunit General function prediction only 50914130 Common - Hypothetical membrane associated protein M6_Spy0784 51 COG3442 COG3442, Predicted glutamine amidotransferase General function prediction only 50915060 Common - Dipeptide transport ATP-binding protein dppF M6_Spy1714 249 COG1124 DppF, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 50913763 Pathogen - hypothetical protein M6_Spy0417 1 None None None 50915196 Common - Transcriptional regulator, TetR family M6_Spy1850 20 COG1309 AcrR, Transcriptional regulator Transcription 50915189 Common - Integral membrane protein M6_Spy1843 26 COG2035 COG2035, Predicted membrane protein Function unknown 161761327 Common rplR 50S ribosomal protein L18 M6_Spy0109 216 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 50913424 Common - phosphoribosylamine--glycine ligase M6_Spy0078 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 50913591 Pathogen - N-acetylneuraminate transport system permease protein M6_Spy0245 1 None None None 50914013 Common rpsP 30S ribosomal protein S16 M6_Spy0667 213 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 50914714 Pathogen - hypothetical protein M6_Spy1368 1 None None None 50914642 Common - arginine deiminase M6_Spy1296 57 COG2235 ArcA, Arginine deiminase Amino acid transport and metabolism 50914246 Pathogen - hypothetical protein M6_Spy0900 1 None None None 50913598 Common - Sec-independent protein translocase protein M6_Spy0252 239 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 50913740 Common - Manganese transport system membrane protein M6_Spy0394 185 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 50913454 Common rplF 50S ribosomal protein L6 M6_Spy0108 246 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 50913715 Common - Permease M6_Spy0369 14 COG3619 COG3619, Predicted membrane protein Function unknown 50915000 Common rpsI 30S ribosomal protein S9 M6_Spy1654 219 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 50914789 Common - Hypothetical membrane spanning protein M6_Spy1443 131 COG2860 COG2860, Predicted membrane protein Function unknown 50914336 Pathogen - unknown phage protein M6_Spy0990 1 None None None 50915110 Common - Cold shock protein M6_Spy1764 184 COG1278 CspC, Cold shock proteins Transcription 50914383 Common - Transposase M6_Spy1037 65 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 50914084 Common - unknown phage protein M6_Spy0738 10 None None None 50913573 Common - Multidrug resistance ABC transporter ATP-binding and permease protein M6_Spy0227 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 50914912 Common - single-strand DNA-binding protein M6_Spy1566 212 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 50913495 Common - Thioredoxin M6_Spy0149 72 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 50914086 Pathogen - Enterotoxin M6_Spy0740 2 None None None 50915023 Common def peptide deformylase M6_Spy1677 212 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 50914345 Pathogen - unknown phage protein M6_Spy0999 1 None None None 50914953 Common - Glutamine synthetase M6_Spy1607 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 50915211 Common - Hypothetical membrane associated protein M6_Spy1865 11 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 50914129 Common - Lipoate-protein ligase A M6_Spy0783 82 COG0095 LplA, Lipoate-protein ligase A Coenzyme metabolism 50913977 Common - peptidase T M6_Spy0631 59 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 50914028 Common - Autolysin M6_Spy0682 18 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 50913393 Common - Phage scaffold protein M6_Spy0047 5 None None None 50914939 Common - Transcriptional regulator, MerR family M6_Spy1593 1 COG0789 SoxR, Predicted transcriptional regulators Transcription 50915083 Pathogen - hypothetical protein M6_Spy1737 1 None None None 50913709 Common - Copper homeostasis protein M6_Spy0363 55 COG3142 CutC, Uncharacterized protein involved in copper resistance Inorganic ion transport and metabolism 50915019 Pathogen - hypothetical protein M6_Spy1673 1 None None None 50913945 Common atpC F0F1 ATP synthase subunit epsilon M6_Spy0599 125 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 50914176 Common - Malate-sodium symport M6_Spy0830 30 COG3493 CitS, Na+/citrate symporter Energy production and conversion 50913793 Common - Bactoprenol glucosyl transferase M6_Spy0447 191 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 50914696 Common - unknown phage protein M6_Spy1350 6 COG4722 COG4722, Phage-related protein Function unknown 50914094 Common miaA tRNA delta(2)-isopentenylpyrophosphate transferase M6_Spy0748 214 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 50914805 Common - Hypothetical cytosolic protein M6_Spy1459 32 COG2740 COG2740, Predicted nucleic-acid-binding protein implicated in transcription termination Transcription 50914652 Common - Magnesium and cobalt transport protein M6_Spy1306 13 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 50915012 Common - Serine acetyltransferase M6_Spy1666 190 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 50915034 Pathogen - hypothetical protein M6_Spy1687 1 None None None 50914222 Common - hypothetical protein M6_Spy0876 119 COG1272 COG1272, Predicted membrane protein, hemolysin III homolog General function prediction only 161761320 Common - HPr kinase/phosphorylase M6_Spy0507 76 COG1493 HprK, Serine kinase of the HPr protein, regulates carbohydrate metabolism Signal transduction mechanisms 50913777 Pathogen - hypothetical protein M6_Spy0431 1 None None None 50913674 Common - hypothetical protein M6_Spy0328 1 COG3763 COG3763, Uncharacterized protein conserved in bacteria Function unknown 50914509 Common - hypothetical protein M6_Spy1163 1 None None None 50913417 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase M6_Spy0071 210 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 50914278 Common - cytidine deaminase M6_Spy0932 119 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 50914227 Common - DNA topoisomerase I M6_Spy0881 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 50913694 Common - FhuB M6_Spy0348 186 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 50913955 Common - ABC transporter ATP-binding protein M6_Spy0609 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 50914280 Common - pantothenate kinase M6_Spy0934 74 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 50914234 Common - Transcriptional regulator, GntR family M6_Spy0888 106 COG1802 GntR, Transcriptional regulators Transcription 50913532 Pathogen - NAD glycohydrolase M6_Spy0186 2 None None None 50914823 Common - seryl-tRNA synthetase M6_Spy1477 247 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 50913799 Common - 1,2-diacylglycerol 3-glucosyltransferase M6_Spy0453 211 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 50914860 Common - Cobalt transport ATP-binding protein M6_Spy1514 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 50914065 Common - hypothetical protein M6_Spy0719 1 None None None 50914672 Common - Sugar-binding protein M6_Spy1326 17 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 50914665 Common - Hypothetical cytosolic protein M6_Spy1319 36 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 50913841 Common - Hydrolase (HAD superfamily) M6_Spy0495 123 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 50914987 Common - 6-phospho-beta-galactosidase M6_Spy1641 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 50914541 Common - MF2 M6_Spy1195 7 None None None 50914289 Common - Phosphate transport system permease protein pstA M6_Spy0943 230 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 50914056 Pathogen - hypothetical protein M6_Spy0710 1 None None None 50915184 Common - hypothetical protein M6_Spy1838 2 None None None 50914867 Common - Ferrichrome-binding protein M6_Spy1521 67 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 50914738 Common - Acetate CoA-transferase beta subunit M6_Spy1392 100 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 50913878 Common - Factor essential for expression of methicillin resistance M6_Spy0532 22 COG2348 COG2348, Uncharacterized protein involved in methicillin resistance Defense mechanisms 50913352 Common - Transcription-repair coupling factor M6_Spy0006 231 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 50913604 Common - RmuC family protein M6_Spy0258 128 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 50914144 Common - methionine sulfoxide reductase B M6_Spy0798 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 50914284 Common - Lysyl aminopeptidase M6_Spy0938 166 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 50914715 Common - Transposase M6_Spy1369 2 None None None 50913686 Common - Membrane-associated phospholipid phosphatase M6_Spy0340 123 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 50914788 Common - Hydrolase (HAD superfamily) M6_Spy1442 140 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 50914251 Common - hypothetical protein M6_Spy0905 28 COG2739 COG2739, Uncharacterized protein conserved in bacteria Function unknown 50914816 Common - ATP/GTP hydrolase M6_Spy1470 191 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 50913507 Common - Sortase M6_Spy0161 15 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 50914169 Common murB UDP-N-acetylenolpyruvoylglucosamine reductase M6_Spy0823 208 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 50914922 Common - ribonuclease HIII M6_Spy1576 28 COG1039 RnhC, Ribonuclease HIII DNA replication, recombination, and repair 50914213 Common - Multidrug resistance ABC transporter ATP-binding and permease protein M6_Spy0867 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 50913349 Common - Hypothetical cytosolic protein M6_Spy0003 23 COG4481 COG4481, Uncharacterized protein conserved in bacteria Function unknown 50913517 Common - Transcriptional regulator pfoR M6_Spy0171 27 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 50913537 Pathogen - hypothetical protein M6_Spy0191 1 None None None 50914201 Common - Xanthine permease M6_Spy0855 127 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 50914045 Common - Mevalonate kinase M6_Spy0699 29 COG1577 ERG12, Mevalonate kinase Lipid metabolism 50914191 Common - GTP pyrophosphokinase M6_Spy0845 73 COG2357 COG2357, Uncharacterized protein conserved in bacteria Function unknown 50914754 Common - Amino acid transport ATP-binding protein M6_Spy1408 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 50913553 Common - Ferric uptake regulation protein M6_Spy0207 191 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 50913872 Common - phosphoenolpyruvate carboxylase M6_Spy0526 116 COG2352 Ppc, Phosphoenolpyruvate carboxylase Energy production and conversion 50914035 Common - Transposase M6_Spy0689 5 COG4835 COG4835, Uncharacterized protein conserved in bacteria Function unknown 50914819 Common - PTS system, mannose-specific IIAB component M6_Spy1473 81 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 50913650 Common - KtrA M6_Spy0304 117 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 50915119 Common - Amino acid permease M6_Spy1773 187 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 50913512 Common - Acetyl-CoA acetyltransferase M6_Spy0166 185 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 50913587 Pathogen - hypothetical protein M6_Spy0241 1 None None None 50915170 Pathogen - unknown phage protein M6_Spy1824 1 None None None 50914611 Common - Cell division initiation protein M6_Spy1265 38 COG3599 DivIVA, Cell division initiation protein Cell division and chromosome partitioning 50913589 Common - N-acetylmannosamine-6-phosphate 2-epimerase M6_Spy0243 43 COG3010 NanE, Putative N-acetylmannosamine-6-phosphate epimerase Carbohydrate transport and metabolism 50915231 Common - Protease Do M6_Spy1885 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 50914849 Common - Pyruvate,phosphate dikinase M6_Spy1503 100 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 50914122 Common - Pyruvate dehydrogenase E1 component alpha subunit M6_Spy0776 155 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 50914618 Common - Cell division protein ftsQ M6_Spy1272 10 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 50914894 Pathogen - unknown phage protein M6_Spy1548 1 None None None 50914842 Common - D-alanyl-D-alanine carboxypeptidase M6_Spy1496 31 COG1876 VanY, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 50913502 Common - Transcriptional regulator M6_Spy0156 2 None None None 50915104 Common - Dipeptidase M6_Spy1758 19 COG4690 PepD, Dipeptidase Amino acid transport and metabolism 50913936 Common ligA NAD-dependent DNA ligase LigA M6_Spy0590 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 50913736 Pathogen - hypothetical protein M6_Spy0390 1 None None None 50913472 Common - High-affinity zinc uptake system ATP-binding protein M6_Spy0126 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 50915228 Common - Transposase M6_Spy1882 65 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 50914765 Common - gamma-glutamyl kinase M6_Spy1419 193 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 50913481 Common - ComG operon protein 2 M6_Spy0135 108 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 50914936 Pathogen - Transcriptional regulator M6_Spy1590 1 None None None 50913780 Common - formamidopyrimidine-DNA glycosylase M6_Spy0434 182 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 50914839 Common - GrpE M6_Spy1493 199 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 50913908 Common - Dipeptidase M6_Spy0562 25 COG4690 PepD, Dipeptidase Amino acid transport and metabolism 50915208 Common - Cobalt transport ATP-binding protein cbiO M6_Spy1862 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 50914350 Pathogen - unknown phage protein M6_Spy1004 1 None None None 50914324 Common - Transcriptional regulator, GntR family M6_Spy0978 72 COG1725 COG1725, Predicted transcriptional regulators Transcription 50913685 Common - Riboflavin transporter M6_Spy0339 19 COG3601 COG3601, Predicted membrane protein Function unknown 50914018 Common - Cobalt-zinc-cadmium resistance protein M6_Spy0672 166 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 50915036 Common - Multiple sugar transport ATP-binding protein M6_Spy1690 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 50914011 Common - ABC transporter permease protein M6_Spy0665 184 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 50914995 Pathogen - DNA-damage-inducible protein J M6_Spy1649 1 None None None 50913590 Common - N-acetylneuraminate-binding protein M6_Spy0244 52 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 50914648 Common - Two-component response regulator YesN M6_Spy1302 224 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 50914155 Common - NAD(P)H-dependent quinone reductase M6_Spy0809 74 COG0778 NfnB, Nitroreductase Energy production and conversion 50914657 Common - hypothetical protein M6_Spy1311 6 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 50913933 Pathogen - hypothetical protein M6_Spy0587 1 None None None 50914520 Common - COME operon protein 3 M6_Spy1174 38 COG0658 ComEC, Predicted membrane metal-binding protein General function prediction only 50914632 Common - Ribose operon repressor M6_Spy1286 94 COG1609 PurR, Transcriptional regulators Transcription 161761322 Common tdk thymidylate kinase M6_Spy0356 228 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 50914626 Common - Ferroxidase M6_Spy1280 112 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 50914050 Common - Hydroxymethylglutaryl-CoA synthase M6_Spy0704 58 COG3425 PksG, 3-hydroxy-3-methylglutaryl CoA synthase Lipid metabolism 50915053 Common - Acetyltransferase M6_Spy1707 5 COG3153 COG3153, Predicted acetyltransferase General function prediction only 50914204 Common - thymidine kinase M6_Spy0858 102 COG1435 Tdk, Thymidine kinase Nucleotide transport and metabolism 50913597 Common - Transcriptional regulator, RpiR family M6_Spy0251 85 COG1737 RpiR, Transcriptional regulators Transcription 161761308 Common recR recombination protein RecR M6_Spy1186 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 161761329 Common - fatty acid/phospholipid synthesis protein M6_Spy0069 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 50914362 Pathogen - unknown phage protein M6_Spy1016 1 None None None 50914586 Pathogen - unknown phage protein M6_Spy1240 1 None None None 50914571 Pathogen - HNH endonuclease family protein M6_Spy1225 1 COG1403 McrA, Restriction endonuclease Defense mechanisms 50914070 Common - Cystine transport system permease protein M6_Spy0724 172 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 50913401 Pathogen - unknown phage protein M6_Spy0055 1 None None None 50913623 Common - ABC transporter-associated protein M6_Spy0277 185 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 50914136 Common - coproporphyrinogen III oxidase M6_Spy0790 208 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 50913431 Common - Protein tyrosine phosphatase M6_Spy0085 116 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 50914979 Pathogen - hypothetical protein M6_Spy1632 1 None None None 50915005 Common - Hypothetical cytosolic protein M6_Spy1659 28 COG3688 COG3688, Predicted RNA-binding protein containing a PIN domain General function prediction only 50914005 Common pyrB aspartate carbamoyltransferase catalytic subunit M6_Spy0659 237 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 50914506 Common - Type II restriction-modification system methylation subunit M6_Spy1160 134 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 50914821 Common - PTS system, mannose-specific IID component M6_Spy1475 41 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 50914566 Pathogen - unknown phage protein M6_Spy1220 1 None None None 50914219 Pathogen - hypothetical protein M6_Spy0873 1 None None None 50915169 Pathogen - Phage encoded transcriptional regulator, ArpU family M6_Spy1823 1 None None None 50914133 Common - Hypothetical membrane associated protein M6_Spy0787 13 COG4856 COG4856, Uncharacterized protein conserved in bacteria Function unknown 50913548 Common - putative L-ascorbate 6-phosphate lactonase M6_Spy0202 21 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 50913660 Common - primosomal protein DnaI M6_Spy0314 40 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 50914553 Pathogen - unknown phage protein M6_Spy1207 1 None None None 50914559 Pathogen - unknown phage protein M6_Spy1213 1 None None None 50914413 Common - Hypothetical cytosolic protein M6_Spy1067 7 COG4868 COG4868, Uncharacterized protein conserved in bacteria Function unknown 50914949 Common - Ribosomal-protein-alanine acetyltransferase M6_Spy1603 63 COG0456 RimI, Acetyltransferases General function prediction only 50914834 Common - 3-oxoacyl-(acyl carrier protein) synthase III M6_Spy1488 210 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 50914109 Common - MutT M6_Spy0763 24 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 50915137 Common - hypothetical protein M6_Spy1791 1 None None None 50913361 Common - Amino acid permease M6_Spy0015 190 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 50913880 Pathogen - Hypothetical cytosolic protein M6_Spy0534 1 None None None 50913745 Pathogen - Transposase M6_Spy0399 1 None None None 50914057 Common - ATP-dependent protease ATP-binding subunit M6_Spy0711 228 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 50914180 Common aphA acid phosphatase/phosphotransferase M6_Spy0834 12 COG3700 AphA, Acid phosphatase (class B) General function prediction only 50914884 Common - Xaa-Pro dipeptidase M6_Spy1538 242 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 50914639 Common - Arginine/ornithine antiporter M6_Spy1293 38 COG1288 COG1288, Predicted membrane protein Function unknown 50914423 Common - Ribosomal-protein-alanine acetyltransferase M6_Spy1077 68 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 50914713 Common - Hypothetical cytosolic protein M6_Spy1367 14 COG3557 COG3557, Uncharacterized domain/protein associated with RNAses G and E Translation, ribosomal structure and biogenesis 50913655 Common - Hypothetical cytosolic protein M6_Spy0309 10 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 50914859 Pathogen - hypothetical protein M6_Spy1513 1 None None None 50913972 Common - Phosphoglycerol transferase M6_Spy0626 27 COG1368 MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily Cell envelope biogenesis, outer membrane 161761317 Common rpsU 30S ribosomal protein S21 M6_Spy0614 95 None None None 50914596 Common - Hemolysin M6_Spy1250 130 COG1189 COG1189, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 50913821 Common - Shikimate 5-dehydrogenase M6_Spy0475 219 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 50913375 Pathogen - unknown phage protein M6_Spy0029 1 None None None 50913925 Common - Streptolysin S biosynthesis protein M6_Spy0579 37 COG0778 NfnB, Nitroreductase Energy production and conversion 50914189 Common - ribose-phosphate pyrophosphokinase M6_Spy0843 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 50913774 Pathogen - hypothetical protein M6_Spy0428 1 None None None 50914232 Common - Oxaloacetate decarboxylase beta chain M6_Spy0886 57 COG1883 OadB, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit Energy production and conversion 50914688 Common - N-acetylmuramoyl-L-alanine amidase M6_Spy1342 67 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 50913640 Common - Methyltransferase M6_Spy0294 94 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 50913834 Common - hypothetical protein M6_Spy0489 3 None None None 50913461 Common - Translation Initiation Factor 1 M6_Spy0115 195 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 50914388 Common - DltB M6_Spy1042 86 COG1696 DltB, Predicted membrane protein involved in D-alanine export Cell envelope biogenesis, outer membrane 50913949 Common - DNA-entry nuclease M6_Spy0603 5 None None None 50914623 Common - Rhodanese-related sulfurtransferase M6_Spy1277 28 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 50914724 Common - Two-component response regulator yvqC M6_Spy1378 216 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 50913920 Common - septation ring formation regulator EzrA M6_Spy0574 31 COG4477 EzrA, Negative regulator of septation ring formation Cell division and chromosome partitioning 50915154 Common - Phage antirepressor protein M6_Spy1808 18 COG3617 COG3617, Prophage antirepressor Transcription 50914705 Common - Major head protein M6_Spy1359 5 None None None 50914783 Common - Sodium-dependent phosphate transporter M6_Spy1437 92 COG1283 NptA, Na+/phosphate symporter Inorganic ion transport and metabolism 50913406 Common - Phage infection protein M6_Spy0060 3 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 50915041 Pathogen - Collagen-like surface protein M6_Spy1695 1 COG4932 COG4932, Predicted outer membrane protein Cell envelope biogenesis, outer membrane 50914210 Common - hypothetical protein M6_Spy0864 6 None None None 50914465 Pathogen - hypothetical protein M6_Spy1119 1 None None None 50913909 Common - High-affinity zinc uptake system protein znuA precursor M6_Spy0563 173 COG3443 COG3443, Predicted periplasmic or secreted protein General function prediction only 50914494 Pathogen - unknown phage protein M6_Spy1148 1 None None None 50914115 Pathogen - hypothetical protein M6_Spy0769 1 None None None 50913989 Common - Hypothetical cytosolic protein M6_Spy0643 18 COG3679 COG3679, Uncharacterized conserved protein Function unknown 50914439 Common - NADP-dependent glyceraldehyde-3-phosphate dehydrogenase M6_Spy1093 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 50913645 Common - ABC transporter substrate-binding protein M6_Spy0299 100 COG1464 NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen Inorganic ion transport and metabolism 50914452 Common - Transcriptional regulator, Cro/CI family M6_Spy1106 51 COG1476 COG1476, Predicted transcriptional regulators Transcription 50915144 Common recA recombinase A M6_Spy1798 217 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 50914248 Common xerS site-specific tyrosine recombinase XerS M6_Spy0902 216 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 50915194 Common - Hypothetical membrane associated protein M6_Spy1848 4 None None None 50913862 Common lysS lysyl-tRNA synthetase M6_Spy0516 248 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 50913994 Common - thiamine biosynthesis protein ThiI M6_Spy0648 94 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 50913456 Common rpsE 30S ribosomal protein S5 M6_Spy0110 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 50913635 Common - GTP-binding protein M6_Spy0289 39 COG1161 COG1161, Predicted GTPases General function prediction only 50915131 Common - Transcriptional regulator, MarR family M6_Spy1785 149 COG1733 COG1733, Predicted transcriptional regulators Transcription 50913917 Common rplS 50S ribosomal protein L19 M6_Spy0571 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 161761297 Common hutH histidine ammonia-lyase M6_Spy1774 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 50913751 Common frr ribosome recycling factor M6_Spy0405 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 50914796 Common - PTS system, galactose-specific IIA component M6_Spy1450 10 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 50913902 Common - bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon M6_Spy0556 147 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 50914870 Common alr alanine racemase M6_Spy1524 200 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 50913565 Common pgi glucose-6-phosphate isomerase M6_Spy0219 191 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 50914319 Common - Transposase M6_Spy0973 53 COG3666 COG3666, Transposase and inactivated derivatives DNA replication, recombination, and repair 50914418 Common aroK shikimate kinase M6_Spy1072 192 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 50914446 Common - Transposase M6_Spy1100 13 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 50914947 Common rpsN 30S ribosomal protein S14 M6_Spy1601 205 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 50914484 Common - Phage Prohead Protease M6_Spy1138 57 COG4653 COG4653, Predicted phage phi-C31 gp36 major capsid-like protein General function prediction only 50913704 Common - Tpl M6_Spy0358 1 None None None 50913629 Common - OppD M6_Spy0283 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 50914442 Common - Glutaredoxin M6_Spy1096 39 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 50914474 Common - Host specificity protein M6_Spy1128 7 COG4926 PblB, Phage-related protein Function unknown 50914224 Common rbgA ribosomal biogenesis GTPase M6_Spy0878 170 COG1161 COG1161, Predicted GTPases General function prediction only 50914370 Common - Phage transcriptional repressor M6_Spy1024 5 COG2932 COG2932, Predicted transcriptional regulator Transcription 50913884 Common - Transcriptional regulator, LacI family M6_Spy0538 126 COG1609 PurR, Transcriptional regulators Transcription 50913806 Common - Transcriptional regulator, TetR family M6_Spy0460 10 COG1309 AcrR, Transcriptional regulator Transcription 50913551 Common - DNA polymerase I M6_Spy0205 217 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 50914879 Common - Sucrose operon repressor M6_Spy1533 127 COG1609 PurR, Transcriptional regulators Transcription 50913449 Common rplN 50S ribosomal protein L14 M6_Spy0103 247 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 50915081 Pathogen - Streptopain precursor M6_Spy1735 4 None None None 50915096 Pathogen - hypothetical protein M6_Spy1750 1 None None None 50913571 Common gpsA NAD(P)H-dependent glycerol-3-phosphate dehydrogenase M6_Spy0225 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 50915077 Pathogen - Hypothetical cytosolic protein M6_Spy1731 1 None None None 50915230 Common - hypothetical protein M6_Spy1884 160 COG1576 COG1576, Uncharacterized conserved protein Function unknown 50914379 Common - MalF M6_Spy1033 153 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 50915079 Pathogen - hypothetical protein M6_Spy1733 1 None None None 50914772 Common - NADH peroxidase M6_Spy1426 222 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 50914604 Common - Amino acid transport ATP-binding protein M6_Spy1258 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 50913790 Common - pyrrolidone-carboxylate peptidase M6_Spy0444 57 COG2039 Pcp, Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase) Posttranslational modification, protein turnover, chaperones 50914675 Common - Glucokinase M6_Spy1329 142 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 50914970 Common - phosphomethylpyrimidine kinase M6_Spy1624 217 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 50914042 Common - GTP pyrophosphokinase M6_Spy0696 24 COG2357 COG2357, Uncharacterized protein conserved in bacteria Function unknown 50915206 Common - Transglycosylase SLT domain family protein M6_Spy1860 2 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 50914404 Pathogen - hypothetical protein M6_Spy1058 1 None None None 50913899 Common - Cell division protein FtsX M6_Spy0553 121 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 50914261 Common - Cardiolipin synthetase M6_Spy0915 146 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 50914985 Common - Serine (threonine) dehydratase M6_Spy1639 16 COG4403 LcnDR2, Lantibiotic modifying enzyme Defense mechanisms 50914178 Common - Zn-dependent alcohol dehydrogenase and related dehydrogenase M6_Spy0832 10 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 50914294 Common - hypothetical protein M6_Spy0948 11 COG4476 COG4476, Uncharacterized protein conserved in bacteria Function unknown 50913969 Common - Polysaccharide export ATP-binding protein M6_Spy0623 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 50913824 Pathogen - hypothetical protein M6_Spy0478 1 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 50914674 Common - Sugar transport system permease protein M6_Spy1328 139 COG4209 LplB, ABC-type polysaccharide transport system, permease component Carbohydrate transport and metabolism 50914021 Common trmD tRNA (guanine-N(1)-)-methyltransferase M6_Spy0675 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 50914710 Common - Minor capsid protein M6_Spy1364 2 None None None 50913355 Pathogen - hypothetical protein M6_Spy0009 1 None None None 50914689 Pathogen - unknown phage protein M6_Spy1343 1 None None None 50914699 Pathogen - unknown phage protein M6_Spy1353 1 None None None 50913585 Common - 60 kDa inner membrane protein YIDC M6_Spy0239 215 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 50914929 Common - C3-degrading proteinase M6_Spy1583 3 None None None 50914638 Common - hypothetical protein M6_Spy1292 142 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 50913608 Common rpsL 30S ribosomal protein S12 M6_Spy0262 238 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 50914327 Common - Putative membrane-associated alkaline phosphatase M6_Spy0981 16 COG0398 COG0398, Uncharacterized conserved protein Function unknown 50914077 Common - Hypothetical cytosolic protein M6_Spy0731 1 None None None 50914963 Common - Alpha/beta hydrolase M6_Spy1617 65 COG1073 COG1073, Hydrolases of the alpha/beta superfamily General function prediction only 50913797 Common - Catabolite control protein A M6_Spy0451 128 COG1609 PurR, Transcriptional regulators Transcription 50914236 Common - hypothetical protein M6_Spy0890 3 None None None 161761301 Common - DNA-directed RNA polymerase subunit delta M6_Spy1619 12 COG3343 RpoE, DNA-directed RNA polymerase, delta subunit Transcription 50914969 Common - Hypothetical membrane spanning protein M6_Spy1623 14 COG4720 COG4720, Predicted membrane protein Function unknown 50914993 Common - galactose-6-phosphate isomerase subunit LacA M6_Spy1647 125 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 50914385 Common - Esterase M6_Spy1039 61 COG0657 Aes, Esterase/lipase Lipid metabolism 50915213 Common - Zinc protease M6_Spy1867 71 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 50915026 Common polC DNA polymerase III PolC M6_Spy1680 215 COG2176 PolC, DNA polymerase III, alpha subunit (gram-positive type) DNA replication, recombination, and repair 50913697 Common murE UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase M6_Spy0351 212 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 50915068 Pathogen - Immunogenic protein M6_Spy1722 1 None None None 50914746 Common recU Holliday junction-specific endonuclease M6_Spy1400 17 COG3331 PrfA, Penicillin-binding protein-related factor A, putative recombinase General function prediction only 50915063 Common - laminin binding protein M6_Spy1717 169 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 50913998 Common - hypothetical ribosome-associated protein M6_Spy0652 13 COG2868 COG2868, Predicted ribosomal protein Translation, ribosomal structure and biogenesis 50915158 Pathogen - unknown phage protein M6_Spy1812 1 None None None 50915156 Common - unknown phage protein M6_Spy1810 7 COG3646 COG3646, Uncharacterized phage-encoded protein Function unknown 50913755 Common - Surface antigen M6_Spy0409 8 None None None 50913534 Common - Streptolysin O M6_Spy0188 6 None None None 50914127 Pathogen - hypothetical protein M6_Spy0781 1 None None None 50914310 Common - hypothetical protein M6_Spy0964 5 None None None 50913975 Common - AmrA M6_Spy0629 21 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 50914910 Common - Hypothetical membrane spanning protein M6_Spy1564 8 COG4858 COG4858, Uncharacterized membrane-bound protein conserved in bacteria Function unknown 50914664 Common - Putative acetate kinase M6_Spy1318 4 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 50914015 Pathogen - hypothetical protein M6_Spy0669 1 None None None 50915032 Common - Thioredoxin M6_Spy1686 2 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 50913527 Common - Tellurite resistance protein M6_Spy0181 17 COG3853 TelA, Uncharacterized protein involved in tellurite resistance Inorganic ion transport and metabolism 50914698 Common - unknown phage protein M6_Spy1352 2 None None None 50913785 Common rpmG 50S ribosomal protein L33 M6_Spy0439 57 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 50915018 Common - PTS system, mannitol (Cryptic)-specific IIA component M6_Spy1672 45 COG3711 BglG, Transcriptional antiterminator Transcription 50913986 Common - Methyltransferase M6_Spy0640 128 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 50914587 Common - DNA replication protein dnaD M6_Spy1241 18 COG3935 DnaD, Putative primosome component and related proteins DNA replication, recombination, and repair 50914353 Common - ATP-dependent Clp protease proteolytic subunit M6_Spy1007 65 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 50914003 Common - pyrimidine regulatory protein PyrR M6_Spy0657 118 COG2065 PyrR, Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase Nucleotide transport and metabolism 50914338 Common - Phage infection protein M6_Spy0992 3 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 50914500 Common - unknown phage protein M6_Spy1154 13 None None None 50914271 Common - phosphopantothenoylcysteine decarboxylase M6_Spy0925 236 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 50913858 Common - Peptidase family U32 M6_Spy0512 114 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 50914592 Common - DegV family protein M6_Spy1246 51 COG1307 DegV, Uncharacterized protein conserved in bacteria Function unknown 50913874 Pathogen - Hypothetical cytosolic protein M6_Spy0528 1 None None None 50914193 Common - Ribosomal large subunit pseudouridine synthase D M6_Spy0847 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 50913509 Common - Short-chain fatty acids transporter M6_Spy0163 42 COG2031 AtoE, Short chain fatty acids transporter Lipid metabolism 50913719 Common nrdI ribonucleotide reductase stimulatory protein M6_Spy0373 37 COG1780 NrdI, Protein involved in ribonucleotide reduction Nucleotide transport and metabolism 50913770 Pathogen - hypothetical protein M6_Spy0424 1 None None None 50914896 Common - Hyaluronoglucosaminidase M6_Spy1550 2 None None None 50913672 Common - Hydrolase (HAD superfamily) M6_Spy0326 11 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 50914253 Pathogen - hypothetical protein M6_Spy0907 1 None None None 50914760 Common - FtsL M6_Spy1414 6 COG4839 FtsL, Protein required for the initiation of cell division Cell division and chromosome partitioning 50913801 Common - Daunorubicin resistance ATP-binding protein M6_Spy0455 249 COG4586 COG4586, ABC-type uncharacterized transport system, ATPase component General function prediction only 50914616 Common - cell division protein FtsZ M6_Spy1270 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 50914120 Common - hypothetical protein M6_Spy0774 1 None None None 50913913 Common - Phosphoesterase, DHH family protein M6_Spy0567 85 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 50914291 Common - Phosphate-binding protein M6_Spy0945 156 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 50915102 Common - Ribosomal large subunit pseudouridine synthase D M6_Spy1756 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 50915112 Common - Peroxiredoxin reductase (NAD(P)H) M6_Spy1766 247 COG3634 AhpF, Alkyl hydroperoxide reductase, large subunit Posttranslational modification, protein turnover, chaperones 50914033 Pathogen - unknown phage protein M6_Spy0687 1 None None None 50915192 Common - Transcriptional regulator, PadR family M6_Spy1846 61 COG1695 COG1695, Predicted transcriptional regulators Transcription 50914126 Common - Dihydrolipoamide dehydrogenase M6_Spy0779 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 50915109 Common - CtsR M6_Spy1763 22 COG4463 CtsR, Transcriptional repressor of class III stress genes Transcription 50913446 Common rplP 50S ribosomal protein L16 M6_Spy0100 218 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 50914840 Common hrcA heat-inducible transcription repressor M6_Spy1494 144 COG1420 HrcA, Transcriptional regulator of heat shock gene Transcription 50914088 Pathogen - hypothetical protein M6_Spy0742 1 None None None 50914767 Common - ABC transporter ATP-binding protein M6_Spy1421 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 50913395 Common - unknown phage protein M6_Spy0049 4 None None None 50914817 Common - Guanine-hypoxanthine permease M6_Spy1471 134 COG2252 COG2252, Permeases General function prediction only 50914847 Common gatA aspartyl/glutamyl-tRNA amidotransferase subunit A M6_Spy1501 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 50913612 Common - hypothetical protein M6_Spy0266 5 None None None 50914940 Common - DNA polymerase III subunit epsilon M6_Spy1594 56 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 50913347 Common dnaA chromosomal replication initiation protein M6_Spy0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 50915039 Common - D-tyrosyl-tRNA deacylase M6_Spy1693 139 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 50914752 Common - Thioredoxin reductase M6_Spy1406 249 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 50913779 Common - Transcriptional regulator M6_Spy0433 7 None None None 50913408 Pathogen - unknown phage protein M6_Spy0062 1 None None None 50914814 Common - Transcriptional regulator, LytR family M6_Spy1468 62 COG1316 LytR, Transcriptional regulator Transcription 50914110 Common - Hypothetical membrane spanning protein M6_Spy0764 215 COG0628 PerM, Predicted permease General function prediction only 50913808 Common - Dihydroxyacetone kinase M6_Spy0462 76 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 50914107 Common - dTDP-4-dehydrorhamnose 3,5-epimerase M6_Spy0761 149 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 50914736 Common - Acetyl-CoA acetyltransferase M6_Spy1390 187 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 50913488 Common - Acetate kinase M6_Spy0142 162 COG0282 ackA, Acetate kinase Energy production and conversion 50913368 Common - unknown phage protein M6_Spy0022 2 None None None 50914206 Common - Peptide release factor-glutamine N5-methyltransferase M6_Spy0860 219 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 50913350 Common - translation-associated GTPase M6_Spy0004 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 50914054 Common clpX ATP-dependent protease ATP-binding subunit M6_Spy0708 232 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 50913602 Common - ribulose-phosphate 3-epimerase M6_Spy0256 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 50914286 Common - Phosphate transport system protein M6_Spy0940 199 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 50913962 Common dnaG DNA primase M6_Spy0616 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 50914920 Common - CvpA family membrane protein M6_Spy1574 9 COG1286 CvpA, Uncharacterized membrane protein, required for colicin V production General function prediction only 50914282 Common - CiaH M6_Spy0936 218 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 50914167 Common - Dihydroneopterin aldolase M6_Spy0821 118 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 50914096 Common - Cystathionine beta-lyase M6_Spy0750 2 COG4468 GalT, Galactose-1-phosphate uridyltransferase Carbohydrate transport and metabolism 50913503 Pathogen - Fibronectin-binding protein M6_Spy0157 3 None None None 50914865 Common - Ferrichrome transport ATP-binding protein M6_Spy1519 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 50915186 Common - hypothetical protein M6_Spy1840 2 None None None 50914243 Common citX 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase M6_Spy0897 24 COG3697 CitX, Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) Coenzyme metabolism / Lipid metabolism 50914215 Common ldh L-lactate dehydrogenase M6_Spy0869 168 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 50913379 Common - unknown phage protein M6_Spy0033 13 None None None 50913493 Common - Transposase M6_Spy0147 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 50915123 Common - Transcriptional regulator, LuxR family M6_Spy1777 47 COG3899 COG3899, Predicted ATPase General function prediction only 50914729 Common - 16S rRNA m(5)C 967 methyltransferase M6_Spy1383 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 50914131 Common - UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase M6_Spy0785 62 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 50914239 Pathogen - hypothetical protein M6_Spy0893 2 None None None 50914032 Pathogen - hypothetical protein M6_Spy0686 2 None None None 50913851 Common - hypothetical protein M6_Spy0505 12 COG3091 SprT, Uncharacterized protein conserved in bacteria Function unknown 50913539 Common leuS leucyl-tRNA synthetase M6_Spy0193 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 50914785 Pathogen - hypothetical protein M6_Spy1438 1 None None None 50914828 Common - acetyl-CoA carboxylase biotin carboxyl carrier protein subunit M6_Spy1482 196 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 50913464 Common - 30S ribosomal protein S11 M6_Spy0118 247 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 50914212 Common - Multidrug resistance ABC transporter ATP-binding and permease protein M6_Spy0866 247 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 50913412 Pathogen - unknown phage protein M6_Spy0066 4 None None None 50913766 Common - Transposase M6_Spy0420 28 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 50914709 Common - Minor capsid protein M6_Spy1363 4 None None None 50914043 Common - Two-component response regulator M6_Spy0697 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 161761315 Common thyA thymidylate synthase M6_Spy0705 135 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 50914774 Common - Alpha-glycerophosphate oxidase M6_Spy1428 146 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 50914421 Common - methionine aminopeptidase M6_Spy1075 240 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 50913944 Common - F0F1 ATP synthase subunit beta M6_Spy0598 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 50914415 Common - Phosphorylase, Pnp/Udp family M6_Spy1069 15 COG2820 Udp, Uridine phosphorylase Nucleotide transport and metabolism 50914872 Common secA preprotein translocase subunit SecA M6_Spy1526 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 50914703 Pathogen - Minor capsid protein M6_Spy1357 1 None None None 50915121 Common - Histidine ammonia-lyase M6_Spy1775 4 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 50914255 Common - UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase M6_Spy0909 19 COG2348 COG2348, Uncharacterized protein involved in methicillin resistance Defense mechanisms 50914525 Common - Kup system potassium uptake protein M6_Spy1179 88 COG3158 Kup, K+ transporter Inorganic ion transport and metabolism 50914411 Common - hypothetical protein M6_Spy1065 26 COG5496 COG5496, Predicted thioesterase General function prediction only 50915199 Common - replicative DNA helicase M6_Spy1853 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 50914682 Common - Sensory transduction protein kinase M6_Spy1336 8 COG2972 COG2972, Predicted signal transduction protein with a C-terminal ATPase domain Signal transduction mechanisms 50914304 Pathogen - hypothetical protein M6_Spy0958 1 None None None 50914606 Common - Hypothetical cytosolic protein M6_Spy1260 5 COG4703 COG4703, Uncharacterized protein conserved in bacteria Function unknown 50914594 Common - RecN M6_Spy1248 209 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 50914700 Common - Major tail shaft protein M6_Spy1354 2 None None None 50913954 Common - ABC transporter permease protein M6_Spy0608 14 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 50913510 Pathogen - Transcriptional regulators, LysR family M6_Spy0164 3 None None None 50914836 Common - enoyl-CoA hydratase M6_Spy1490 176 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 50914359 Common - Phage endonuclease M6_Spy1013 10 COG1403 McrA, Restriction endonuclease Defense mechanisms 50914514 Common - Site-specific recombinase M6_Spy1168 71 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 50913974 Common - hypothetical protein M6_Spy0628 5 None None None 50913667 Common greA transcription elongation factor GreA M6_Spy0321 202 COG0782 GreA, Transcription elongation factor Transcription 50914157 Common trmE tRNA modification GTPase TrmE M6_Spy0811 224 COG0486 ThdF, Predicted GTPase General function prediction only 50913729 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase M6_Spy0383 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 50915160 Common - unknown phage protein M6_Spy1814 2 None None None 50913782 Common - ATPase M6_Spy0436 77 COG0433 COG0433, Predicted ATPase General function prediction only 50913707 Common - corrin/porphyrin methyltransferase M6_Spy0361 209 COG0313 COG0313, Predicted methyltransferases General function prediction only 50914628 Common - Florfenicol resistance protein M6_Spy1282 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 50914072 Common pyrC dihydroorotase M6_Spy0726 213 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 50914731 Common - primosome assembly protein PriA M6_Spy1385 212 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 50913423 Common - Autolysin M6_Spy0077 8 COG3942 COG3942, Surface antigen General function prediction only 50914646 Common - Hypothetical cytosolic protein M6_Spy1300 12 COG2315 MmcQ, Uncharacterized protein conserved in bacteria Function unknown 50913403 Pathogen - unknown phage protein M6_Spy0057 1 None None None 50915051 Common - recombination factor protein RarA M6_Spy1705 242 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 50914430 Common - biotin--protein ligase M6_Spy1084 171 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 50913595 Common - N-acetylneuraminate lyase M6_Spy0249 230 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 50913683 Common - hypothetical protein M6_Spy0337 186 COG0759 COG0759, Uncharacterized conserved protein Function unknown 50913931 Common - SagH M6_Spy0585 36 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 50913743 Common - Integral membrane protein M6_Spy0397 1 None None None 50915204 Common - L-serine dehydratase beta subunit M6_Spy1858 145 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 161761324 Common - V-type ATP synthase subunit A M6_Spy0178 247 COG1155 NtpA, Archaeal/vacuolar-type H+-ATPase subunit A Energy production and conversion 50914560 Pathogen - unknown phage protein M6_Spy1214 1 None None None 50915224 Common - Hypothetical membrane spanning protein M6_Spy1878 51 COG1284 COG1284, Uncharacterized conserved protein Function unknown 50913904 Common asnC asparaginyl-tRNA synthetase M6_Spy0558 249 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 50913647 Common - ABC transporter permease protein M6_Spy0301 99 COG2011 AbcD, ABC-type metal ion transport system, permease component Inorganic ion transport and metabolism 50914579 Pathogen - unknown phage protein M6_Spy1233 1 None None None 50913614 Common - ABC transporter amino acid-binding protein M6_Spy0268 175 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 50913788 Common smpB SsrA-binding protein M6_Spy0442 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 50913679 Common xerD site-specific tyrosine recombinase XerD-like protein M6_Spy0333 5 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 50913968 Common - Polysaccharide export ABC transporter permease protein M6_Spy0622 92 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 50915229 Common - Transposase M6_Spy1883 4 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 50914317 Common - PTS system, mannitol-specific IIBC component M6_Spy0971 41 COG2213 MtlA, Phosphotransferase system, mannitol-specific IIBC component Carbohydrate transport and metabolism 50914331 Pathogen - SpeC variant M6_Spy0985 2 None None None 50914483 Common - unknown phage protein M6_Spy1137 2 None None None 50915133 Common - hypothetical protein M6_Spy1787 75 COG3022 COG3022, Uncharacterized protein conserved in bacteria Function unknown 50914341 Common - unknown phage protein M6_Spy0995 6 COG4722 COG4722, Phage-related protein Function unknown 161761299 Common groEL chaperonin GroEL M6_Spy1760 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 50913439 Common rplC 50S ribosomal protein L3 M6_Spy0093 249 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 50913915 Common - hypothetical protein M6_Spy0569 20 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 50913816 Common - VicK M6_Spy0470 222 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 50913828 Pathogen - hypothetical protein M6_Spy0482 1 None None None 50915146 Common - DNA-3-methyladenine glycosylase M6_Spy1800 132 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 50914902 Common - Major tail protein M6_Spy1556 7 None None None 50914472 Pathogen - Phage-associated cell wall hydrolase M6_Spy1126 1 None None None 50914150 Common - Two-component sensor kinase YesM M6_Spy0804 103 COG2972 COG2972, Predicted signal transduction protein with a C-terminal ATPase domain Signal transduction mechanisms 50913753 Common - methionine sulfoxide reductase A M6_Spy0407 205 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 50914794 Common - PTS system, galactose-specific IIC component M6_Spy1448 19 COG3775 GatC, Phosphotransferase system, galactitol-specific IIC component Carbohydrate transport and metabolism 50913522 Common - V-type sodium ATP synthase subunit C M6_Spy0176 7 COG1527 NtpC, Archaeal/vacuolar-type H+-ATPase subunit C Energy production and conversion 50913625 Common - D-alanyl-D-alanine carboxypeptidase M6_Spy0279 147 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 50913671 Common - 23S rRNA methyltransferase M6_Spy0325 206 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 50913385 Pathogen - unknown phage protein M6_Spy0039 1 None None None 50913373 Pathogen - unknown phage protein M6_Spy0027 1 None None None 50913988 Common - chorismate synthase M6_Spy0642 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 50914538 Pathogen - hypothetical protein M6_Spy1192 1 None None None 50915175 Common - Hypothetical membrane spanning protein M6_Spy1829 62 COG1284 COG1284, Uncharacterized conserved protein Function unknown 50914444 Common nrdF ribonucleotide-diphosphate reductase subunit beta M6_Spy1098 149 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 50915098 Common rpmG 50S ribosomal protein L33 M6_Spy1752 39 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 50914399 Common - outer surface protein M6_Spy1053 17 COG3589 COG3589, Uncharacterized conserved protein Function unknown 50914390 Common - excinuclease ABC subunit B M6_Spy1044 227 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 50913959 Common - Arginine-binding protein M6_Spy0613 179 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 50913836 Common - Plasmid stabilization system toxin protein M6_Spy0490 13 COG3668 ParE, Plasmid stabilization system protein General function prediction only 50913714 Pathogen - hypothetical protein M6_Spy0368 1 None None None 50913826 Pathogen - Hypothetical membrane associated protein M6_Spy0480 1 COG1493 HprK, Serine kinase of the HPr protein, regulates carbohydrate metabolism Signal transduction mechanisms 50914722 Common - hypothetical protein M6_Spy1376 217 COG1098 VacB, Predicted RNA binding protein (contains ribosomal protein S1 domain) Translation, ribosomal structure and biogenesis 50913724 Pathogen - Hypothetical membrane spanning protein M6_Spy0378 1 None None None 50913463 Common rpsM 30S ribosomal protein S13 M6_Spy0117 242 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 50913474 Common - Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) M6_Spy0128 15 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 50913838 Common - Portal protein M6_Spy0492 38 COG4695 COG4695, Phage-related protein Function unknown 50914184 Common radC DNA repair protein RadC M6_Spy0838 178 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 50913558 Common - BioY M6_Spy0212 65 COG1268 BioY, Uncharacterized conserved protein General function prediction only 50914406 Common - Transposase M6_Spy1060 134 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 50914113 Pathogen - hypothetical protein M6_Spy0767 1 None None None 50914543 Common - Phage-associated cell wall hydrolase M6_Spy1197 54 COG3666 COG3666, Transposase and inactivated derivatives DNA replication, recombination, and repair 50913848 Common - Hypothetical membrane spanning protein M6_Spy0502 98 COG0701 COG0701, Predicted permeases General function prediction only 50914459 Common - Ribosomal small subunit pseudouridine synthase A M6_Spy1113 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 50914492 Common - Phage endonuclease M6_Spy1146 33 COG1403 McrA, Restriction endonuclease Defense mechanisms 50914241 Common - Citrate lyase beta chain M6_Spy0895 112 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 50913999 Common rpmA 50S ribosomal protein L27 M6_Spy0653 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 50914577 Pathogen - unknown phage protein M6_Spy1231 1 None None None 50914437 Common - ATP-dependent RNA helicase M6_Spy1091 234 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 50913860 Pathogen - hypothetical protein M6_Spy0514 1 None None None 50914589 Common - DNA-binding protein HU M6_Spy1243 210 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 50915070 Common - Two component system histidine kinase M6_Spy1724 215 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 50915138 Common - anaerobic ribonucleoside triphosphate reductase M6_Spy1792 112 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 50913992 Pathogen - hypothetical protein M6_Spy0646 1 None None None 50915072 Common - ABC transporter permease protein M6_Spy1726 166 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 50915197 Common rpsD 30S ribosomal protein S4 M6_Spy1851 249 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 50914434 Common - Hypothetical membrane spanning protein M6_Spy1088 4 COG2339 COG2339, Predicted membrane protein Function unknown 50913437 Common - Na+ driven multidrug efflux pump M6_Spy0091 170 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 50913468 Pathogen - hypothetical protein M6_Spy0122 1 None None None 50914991 Common - Tagatose-6-phosphate kinase M6_Spy1645 95 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 50914726 Common - Transporter yvqF M6_Spy1380 9 COG4758 COG4758, Predicted membrane protein Function unknown 50913631 Common - Transposase M6_Spy0285 1 None None None 50913892 Common - hypothetical protein M6_Spy0546 21 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 50913964 Common - Hypothetical cytosolic protein M6_Spy0618 143 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 50914906 Common - Portal protein M6_Spy1560 11 None None None 50915149 Common mutL DNA mismatch repair protein M6_Spy1803 191 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 50913492 Pathogen - hypothetical protein M6_Spy0146 1 None None None 50913846 Common - 6-phospho-beta-glucosidase M6_Spy0500 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 50913545 Common araD L-ribulose-5-phosphate 4-epimerase M6_Spy0199 143 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 50914835 Common - Transcriptional regulator, MarR family M6_Spy1489 80 COG1846 MarR, Transcriptional regulators Transcription 50914539 Common - Lead, cadmium, zinc and mercury transporting ATPase M6_Spy1193 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 50913378 Common - unknown phage protein M6_Spy0032 15 None None None 50914601 Common - phosphoglucomutase M6_Spy1255 234 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 50914427 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase M6_Spy1081 214 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 50913627 Common - OppB M6_Spy0281 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 50913924 Pathogen - Streptolysin S precursor M6_Spy0578 1 None None None 50915151 Pathogen - hypothetical protein M6_Spy1805 1 None None None 50914440 Common - Phosphoenolpyruvate-protein phosphotransferase M6_Spy1094 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 50913465 Common - DNA-directed RNA polymerase subunit alpha M6_Spy0119 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 50914148 Common - PTS system, mannose/fructose family IIC component M6_Spy0802 36 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 50914463 Common - hypothetical protein M6_Spy1117 1 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 50914245 Common - [Citrate [pro-3S]-lyase] ligase M6_Spy0899 25 COG3053 CitC, Citrate lyase synthetase Energy production and conversion 50914499 Common - unknown phage protein M6_Spy1153 15 None None None 50914784 Pathogen - hypothetical protein M6_Spy1439 1 None None None 50914392 Common - Glutamine transport ATP-binding protein M6_Spy1046 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 50913888 Common - PTS system, N-acetylgalactosamine-specific IIB component M6_Spy0542 39 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 50914060 Common - Arsenate reductase family protein M6_Spy0714 103 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 50914915 Common - A/G-specific adenine DNA glycosylase M6_Spy1569 211 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 50913644 Common - ABC transporter substrate-binding protein M6_Spy0298 107 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 50914369 Pathogen - unknown phage protein M6_Spy1023 1 None None None 50915086 Common - Low temperature requirement C protein M6_Spy1740 13 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 50913649 Common - Serine/threonine sodium symporter M6_Spy0303 154 COG3633 SstT, Na+/serine symporter Amino acid transport and metabolism 50913682 Common - Ribosomal large subunit pseudouridine synthase B M6_Spy0336 207 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 50914873 Common - Transposase M6_Spy1527 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 50914417 Common - Transcriptional regulator, LytR family M6_Spy1071 61 COG1316 LytR, Transcriptional regulator Transcription 50914531 Common ddl D-alanyl-alanine synthetase A M6_Spy1185 216 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 50913919 Common gyrB DNA gyrase subunit B M6_Spy0573 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 50913389 Common - Portal protein M6_Spy0043 8 None None None 50914998 Common - DNA integration/recombination/invertion protein M6_Spy1652 18 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 50914315 Common - Cobalt-zinc-cadmium resistance protein M6_Spy0969 186 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 50913636 Common - Hypothetical RNA binding protein M6_Spy0290 96 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 50915057 Common - Dipeptide transport system permease protein dppB M6_Spy1711 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 50913739 Common - Manganese transport system ATP-binding protein M6_Spy0393 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 50914930 Common - Hypothetical membrane spanning protein M6_Spy1584 11 COG0730 COG0730, Predicted permeases General function prediction only 50915223 Pathogen - hypothetical protein M6_Spy1877 1 None None None 50915216 Common - UDP-glucose 6-dehydrogenase M6_Spy1870 199 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 50914580 Common - unknown phage protein M6_Spy1234 5 None None None 50913867 Common - N-acetylmuramoyl-L-alanine amidase M6_Spy0521 8 COG3757 Acm, Lyzozyme M1 (1,4-beta-N-acetylmuramidase) Cell envelope biogenesis, outer membrane 50913583 Common - FasA M6_Spy0237 28 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 50913405 Common - Hyaluronoglucosaminidase M6_Spy0059 2 None None None 50914300 Common - Type I restriction-modification system specificity subunit M6_Spy0954 8 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 50914643 Common - Transcription regulator, crp family M6_Spy1297 120 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 50913567 Pathogen - hypothetical protein M6_Spy0221 1 None None None 50913760 Common - Diacylglycerol kinase M6_Spy0414 100 COG0818 DgkA, Diacylglycerol kinase Cell envelope biogenesis, outer membrane 50913560 Common - tRNA-specific adenosine deaminase M6_Spy0214 212 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 50914491 Common - Zinc-finger protein M6_Spy1145 2 COG2522 COG2522, Predicted transcriptional regulator General function prediction only 50913914 Common - flavodoxin M6_Spy0568 94 COG0716 FldA, Flavodoxins Energy production and conversion 50913536 Pathogen - hypothetical protein M6_Spy0190 1 None None None 50913486 Common - ComG operon protein 6 M6_Spy0140 1 None None None 50914355 Pathogen - unknown phage protein M6_Spy1009 1 None None None 50913718 Common nrdF ribonucleotide-diphosphate reductase subunit beta M6_Spy0372 60 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 50914014 Common - RNA binding protein M6_Spy0668 14 COG1837 COG1837, Predicted RNA-binding protein (contains KH domain) General function prediction only 50914009 Common - periplasmic component of efflux system M6_Spy0663 60 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 50914578 Common - unknown phage protein M6_Spy1232 3 None None None 50913996 Common - Transposase M6_Spy0650 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 50914748 Common - Aminopeptidase C M6_Spy1402 17 COG3579 PepC, Aminopeptidase C Amino acid transport and metabolism 50914066 Common - orotidine 5'-phosphate decarboxylase M6_Spy0720 164 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 50914635 Common - Methyltransferase M6_Spy1289 211 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 50913577 Common - DNA repair protein RadA M6_Spy0231 212 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 50914501 Common - phage-related DNA polymerase M6_Spy1155 178 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 50913741 Common - Peptidyl-prolyl cis-trans isomerase M6_Spy0395 201 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 50914328 Common - unknown phage protein M6_Spy0982 1 None None None 50914332 Common - Phage-associated cell wall hydrolase M6_Spy0986 3 None None None 50914608 Common - MutT M6_Spy1262 26 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 50913592 Common - N-acetylneuraminate transport system permease protein M6_Spy0246 140 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 50914555 Common - Major tail protein M6_Spy1209 4 None None None 50913728 Common - hypothetical protein M6_Spy0382 5 None None None 50914079 Common - Transposase M6_Spy0733 3 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 50913579 Common - hypothetical protein M6_Spy0233 75 COG2013 COG2013, Uncharacterized conserved protein Function unknown 50914349 Pathogen - unknown phage protein M6_Spy1003 1 None None None 50915004 Common - DegV family protein M6_Spy1658 54 COG1307 DegV, Uncharacterized protein conserved in bacteria Function unknown 50914321 Common - pyruvate kinase M6_Spy0975 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 50913599 Common - Ribonuclease M5 M6_Spy0253 21 COG1658 COG1658, Small primase-like proteins (Toprim domain) DNA replication, recombination, and repair 50914002 Common - Ribosomal large subunit pseudouridine synthase D M6_Spy0656 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 50914653 Common - NAD-dependent oxidoreductase M6_Spy1307 137 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 50914881 Common - General stress protein, Gls24 family M6_Spy1535 30 COG1302 COG1302, Uncharacterized protein conserved in bacteria Function unknown 50913681 Common scpB segregation and condensation protein B M6_Spy0335 153 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 50913475 Common - tyrosyl-tRNA synthetase M6_Spy0129 217 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 50914151 Common - Two-component response regulator YesN M6_Spy0805 185 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 50914685 Common - Sda M6_Spy1339 4 None None None 50914258 Common - pyridoxamine kinase M6_Spy0912 23 COG2240 PdxK, Pyridoxal/pyridoxine/pyridoxamine kinase Coenzyme metabolism 50914372 Common - DNA integration/recombination/invertion protein M6_Spy1026 165 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 50913769 Pathogen - Hypothetical membrane associated protein M6_Spy0423 1 None None None 50915181 Common rpmG 50S ribosomal protein L33 M6_Spy1835 74 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 50914458 Common - Putative competence protein/transcription factor M6_Spy1112 13 COG4469 CoiA, Competence protein General function prediction only 50915163 Common - Virulence-associated protein E M6_Spy1817 25 COG3378 COG3378, Predicted ATPase General function prediction only 50915165 Pathogen - unknown phage protein M6_Spy1819 1 None None None 50913951 Common pheT phenylalanyl-tRNA synthetase subunit beta M6_Spy0605 245 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 50914510 Common - hypothetical protein M6_Spy1164 1 None None None 50913427 Common - Hypothetical cytosolic protein M6_Spy0081 2 None None None 50914568 Common - unknown phage protein M6_Spy1222 2 None None None 50914106 Common - Glucose-1-phosphate thymidylyltransferase M6_Spy0760 234 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 50914515 Common - hypothetical protein M6_Spy1169 2 None None None 50915141 Common - Holliday junction resolvase-like protein M6_Spy1795 183 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 50914030 Common - Transposase M6_Spy0684 4 None None None 161761314 Common - dipeptidase PepV M6_Spy0810 157 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 50914138 Common - 4-nitrophenylphosphatase M6_Spy0792 94 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 50914102 Common - Endonuclease III M6_Spy0756 240 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 50913852 Common - stress-responsive transcriptional regulator M6_Spy0506 2 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 50914830 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase M6_Spy1484 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 50913757 Common - PhoH M6_Spy0411 199 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 50913663 Common - Hypothetical cytosolic protein M6_Spy0317 1 None None None 50914684 Common - unknown phage protein M6_Spy1338 1 None None None 50913748 Common rplA 50S ribosomal protein L1 M6_Spy0402 238 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 161761294 Common - tryptophanyl-tRNA synthetase II M6_Spy1876 248 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 50914360 Pathogen - Phage encoded transcriptional regulator, ArpU family M6_Spy1014 2 None None None 50914340 Common - Phage endopeptidase M6_Spy0994 5 COG4926 PblB, Phage-related protein Function unknown 50914984 Common - Lantibiotic transport ATP-binding protein M6_Spy1638 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 50913854 Common - prolipoprotein diacylglyceryl transferase M6_Spy0508 208 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 50914661 Common - 3-deoxy-7-phosphoheptulonate synthase M6_Spy1315 186 COG2876 AroA, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 50915065 Common - M protein M6_Spy1719 8 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 50914942 Common - NAD(FAD)-utilizing dehydrogenase M6_Spy1596 142 COG2081 COG2081, Predicted flavoproteins General function prediction only 50914488 Common - Phage Terminase Small Subunit M6_Spy1142 23 COG3747 COG3747, Phage terminase, small subunit DNA replication, recombination, and repair 50913421 Common purN phosphoribosylglycinamide formyltransferase M6_Spy0075 220 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 50914290 Common - Phosphate transport system permease protein pstC M6_Spy0944 227 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 50914853 Common - Universal stress protein family M6_Spy1507 109 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 50913784 Common - Multidrug resistance protein B M6_Spy0438 101 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 50914550 Common - Phage endopeptidase M6_Spy1204 6 COG4926 PblB, Phage-related protein Function unknown 50914025 Common - Fructose repressor M6_Spy0679 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 50913618 Common - Undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase M6_Spy0272 225 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 50914546 Pathogen - unknown phage protein M6_Spy1200 1 None None None 50914759 Common - Division specific D,D-transpeptidase M6_Spy1413 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 50914663 Pathogen - hypothetical protein M6_Spy1317 1 None None None 50914629 Common - Transcriptional regulator M6_Spy1283 11 COG4470 COG4470, Uncharacterized protein conserved in bacteria Function unknown 50914811 Common - EcsA M6_Spy1465 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 50914481 Common - prophage pi2 protein 37 M6_Spy1135 5 None None None 50913985 Common - Phosphoglycerol transferase M6_Spy0639 56 COG1368 MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily Cell envelope biogenesis, outer membrane 50914288 Common - Phosphate transport ATP-binding protein pstB M6_Spy0942 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 50913442 Common rplB 50S ribosomal protein L2 M6_Spy0096 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 50914890 Common - Phage-associated cell wall hydrolase M6_Spy1544 3 None None None 50914926 Common - DNA polymerase IV M6_Spy1580 185 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 50913654 Common - heat shock protein HtpX M6_Spy0308 188 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 50914743 Common - Methyltransferase M6_Spy1397 132 COG0116 COG0116, Predicted N6-adenine-specific DNA methylase DNA replication, recombination, and repair 50914456 Common - Oxalate/formate antiporter M6_Spy1110 123 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 50914068 Common - amidase M6_Spy0722 216 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 50914119 Common - Acetyl esterase M6_Spy0773 49 COG0627 COG0627, Predicted esterase General function prediction only 50914863 Common - ABC transporter ATP-binding protein M6_Spy1517 241 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 50914763 Pathogen - hypothetical protein M6_Spy1417 1 None None None 50914165 Common folE GTP cyclohydrolase I M6_Spy0819 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 50914885 Common uvrA excinuclease ABC subunit A M6_Spy1539 240 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 50915124 Common - Transposase M6_Spy1778 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 50914429 Common - Internalin protein M6_Spy1083 38 COG4886 COG4886, Leucine-rich repeat (LRR) protein Function unknown 50915174 Common - Bacteriocin M6_Spy1828 3 None None None 50914846 Common gatB aspartyl/glutamyl-tRNA amidotransferase subunit B M6_Spy1500 214 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 50914062 Common - Purine nucleoside phosphorylase M6_Spy0716 93 COG0813 DeoD, Purine-nucleoside phosphorylase Nucleotide transport and metabolism 50914750 Common - nicotinate phosphoribosyltransferase M6_Spy1404 116 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 161761326 Common secY preprotein translocase subunit SecY M6_Spy0113 220 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 50914076 Common - branched-chain amino acid aminotransferase M6_Spy0730 198 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 50915115 Common - glutamate formiminotransferase M6_Spy1769 22 COG3643 COG3643, Glutamate formiminotransferase Amino acid transport and metabolism 50913900 Common - Hydroxyacylglutathione hydrolase M6_Spy0554 196 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 50914207 Common - Sua5 M6_Spy0861 239 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 50914039 Pathogen - hypothetical protein M6_Spy0693 1 None None None 50914099 Common - RecJ M6_Spy0753 194 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 50915101 Common - Hypothetical cytosolic protein M6_Spy1755 1 None None None 50915108 Common - ClpC M6_Spy1762 230 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 50915190 Common - Phosphohydrolase (MutT/nudix family protein) M6_Spy1844 9 None None None 50913499 Common - tRNA-dihydrouridine synthase M6_Spy0153 212 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 50914049 Common - 3-hydroxy-3-methylglutaryl-coenzyme A reductase M6_Spy0703 51 COG1257 HMG1, Hydroxymethylglutaryl-CoA reductase Lipid metabolism 50914776 Common - Hypothetical membrane associated protein M6_Spy1430 2 COG3212 COG3212, Predicted membrane protein Function unknown 50913428 Common - adenylosuccinate lyase M6_Spy0082 239 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 50914374 Common - unknown phage protein M6_Spy1028 4 None None None 50913506 Common - Fimbrial structural subunit M6_Spy0160 13 COG4932 COG4932, Predicted outer membrane protein Cell envelope biogenesis, outer membrane 50913700 Common clpP ATP-dependent Clp protease proteolytic subunit M6_Spy0354 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 50913734 Common - Hypothetical membrane associated protein M6_Spy0388 1 None None None 50914089 Common - hypothetical protein M6_Spy0743 109 COG1054 COG1054, Predicted sulfurtransferase General function prediction only 50913692 Common - Hypothetical cytosolic protein M6_Spy0346 3 None None None 50913705 Common - Signal peptidase-like protein M6_Spy0359 1 COG1774 COG1774, Uncharacterized homolog of PSP1 Function unknown 50915014 Common - polynucleotide phosphorylase/polyadenylase M6_Spy1668 236 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 50914935 Pathogen - Transcriptional regulator, Cro/CI family M6_Spy1589 2 None None None 50915037 Common - Leucine rich protein M6_Spy1691 5 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 50914523 Common - Methyltransferase M6_Spy1176 73 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 50914298 Common - hypothetical protein M6_Spy0952 39 COG4487 COG4487, Uncharacterized protein conserved in bacteria Function unknown 50913523 Common - V-type ATP synthase subunit F M6_Spy0177 5 COG1436 NtpG, Archaeal/vacuolar-type H+-ATPase subunit F Energy production and conversion 50915028 Common - Pheromone-processing membrane metalloprotease M6_Spy1682 205 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 50914216 Common - DNA gyrase subunit A M6_Spy0870 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 50914951 Common - Putative transcriptional regulator M6_Spy1605 11 COG5503 COG5503, Uncharacterized conserved small protein Function unknown 50914276 Common - Nucleoside transport ATP-binding protein M6_Spy0930 249 COG3845 COG3845, ABC-type uncharacterized transport systems, ATPase components General function prediction only 50913581 Common - FasB M6_Spy0235 12 COG2972 COG2972, Predicted signal transduction protein with a C-terminal ATPase domain Signal transduction mechanisms 50914691 Pathogen - unknown phage protein M6_Spy1345 1 None None None 50913607 Common - Surface exclusion protein M6_Spy0261 3 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 50914958 Common - Membrane protease protein family M6_Spy1612 213 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 50913778 Pathogen - hypothetical protein M6_Spy0432 1 None None None 50915029 Common - Phosphatidate cytidylyltransferase M6_Spy1683 215 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 50914124 Common - branched-chain alpha-keto acid dehydrogenase subunit E2 M6_Spy0778 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 50913942 Common - F0F1 ATP synthase subunit alpha M6_Spy0596 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 50915062 Pathogen - Streptococcal histidine triad protein M6_Spy1716 1 None None None 50914614 Common - Hypothetical cytosolic protein M6_Spy1268 29 COG1799 COG1799, Uncharacterized protein conserved in bacteria Function unknown 50914802 Common rbfA ribosome-binding factor A M6_Spy1456 165 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 50915074 Common - periplasmic component of efflux system M6_Spy1728 38 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 50914080 Common - Transposase M6_Spy0734 133 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 50914181 Common - Chloride channel protein M6_Spy0835 132 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 50913515 Common - Putative DNA-binding protein M6_Spy0169 40 COG2964 COG2964, Uncharacterized protein conserved in bacteria Function unknown 50913678 Common - CBS domain containing protein M6_Spy0332 14 COG4109 COG4109, Predicted transcriptional regulator containing CBS domains Transcription 50914956 Common pgk phosphoglycerate kinase M6_Spy1610 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 50914972 Common - Competence-specific sigma factor M6_Spy1626 4 None None None 50914263 Common - Lipoate-protein ligase A M6_Spy0917 70 COG0095 LplA, Lipoate-protein ligase A Coenzyme metabolism 50913865 Common - Transcriptional regulator M6_Spy0519 99 COG2606 EbsC, Uncharacterized conserved protein Function unknown 50914721 Common - Cysteine synthase M6_Spy1375 220 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 50913897 Common - peptide chain release factor 2 M6_Spy0551 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 50913359 Common - Cell division protein ftsH M6_Spy0013 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 50913413 Common - Sdn M6_Spy0067 4 None None None 50914053 Common - Hypothetical membrane associated protein M6_Spy0707 2 None None None 50915048 Common - Amidase family protein M6_Spy1702 190 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 50914511 Common - Macrolide-specific ABC-type efflux carrier M6_Spy1165 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 50913831 Common - Transcriptional regulator M6_Spy0485 9 COG3655 COG3655, Predicted transcriptional regulator Transcription 50915201 Common - Phosphoesterase, DHH family protein M6_Spy1855 39 COG3887 COG3887, Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain Signal transduction mechanisms 50913371 Pathogen - unknown phage protein M6_Spy0025 1 None None None 50913691 Common - putative manganese-dependent inorganic pyrophosphatase M6_Spy0345 53 COG1227 PPX1, Inorganic pyrophosphatase/exopolyphosphatase Energy production and conversion 50913796 Common - Xaa-Pro dipeptidase M6_Spy0450 248 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 50914982 Common - ABC transporter permease protein M6_Spy1636 6 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 50914679 Common - Transcriptional regulator, GntR family M6_Spy1333 125 COG1609 PurR, Transcriptional regulators Transcription 50914964 Common - CTP synthetase M6_Spy1618 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 50914900 Common - unknown phage protein M6_Spy1554 3 None None None 50914676 Pathogen - hypothetical protein M6_Spy1330 1 None None None 50914171 Common - PotB M6_Spy0825 199 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 50913383 Common - Phage-related DNA helicase M6_Spy0037 103 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 50913929 Pathogen - SagF M6_Spy0583 1 None None None 161761303 Common gatC aspartyl/glutamyl-tRNA amidotransferase subunit C M6_Spy1502 28 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 50914803 Common infB translation initiation factor IF-2 M6_Spy1457 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 50913356 Common - Beta-lactamase M6_Spy0010 9 COG2367 PenP, Beta-lactamase class A Defense mechanisms 50914898 Common - unknown phage protein M6_Spy1552 6 COG4722 COG4722, Phage-related protein Function unknown 50913659 Common - Replicative DNA helicase M6_Spy0313 13 COG3611 DnaB, Replication initiation/membrane attachment protein DNA replication, recombination, and repair 50914141 Pathogen - Nucleoside diphosphate kinase M6_Spy0795 1 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 50914295 Common spxA transcriptional regulator Spx M6_Spy0949 66 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 50915173 Common argS arginyl-tRNA synthetase M6_Spy1827 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 161761316 Common carB carbamoyl phosphate synthase large subunit M6_Spy0662 236 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 50914883 Common - ComE operon protein 2 M6_Spy1537 102 COG2131 ComEB, Deoxycytidylate deaminase Nucleotide transport and metabolism 50913387 Common - Phage Terminase Small Subunit M6_Spy0041 12 COG3728 XtmA, Phage terminase, small subunit DNA replication, recombination, and repair 50913765 Pathogen - hypothetical protein M6_Spy0419 1 None None None 50914432 Common - DNA polymerase III subunits gamma and tau M6_Spy1086 248 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 50914451 Pathogen - Hypothetical membrane spanning protein M6_Spy1105 1 None None None 50915218 Common - Hypothetical cytosolic protein M6_Spy1872 21 COG2501 COG2501, Uncharacterized conserved protein Function unknown 50913905 Common - hypothetical protein M6_Spy0559 140 COG1660 COG1660, Predicted P-loop-containing kinase General function prediction only 50913632 Pathogen - hypothetical protein M6_Spy0286 1 None None None 50913451 Common rplE 50S ribosomal protein L5 M6_Spy0105 247 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 50914449 Common - Transposase M6_Spy1103 100 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 50914799 Common - Copper chaperone M6_Spy1453 18 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 50915178 Common aspS aspartyl-tRNA synthetase M6_Spy1832 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 50914528 Pathogen - hypothetical protein M6_Spy1181 1 None None None 50914792 Common - galactose-6-phosphate isomerase subunit LacB M6_Spy1446 128 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 50914603 Common - Deoxyribodipyrimidine photolyase M6_Spy1257 136 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 50914944 Common - Nucleoside permease nupC M6_Spy1598 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 50913638 Common - Hydrolase (HAD superfamily) M6_Spy0292 43 COG1713 COG1713, Predicted HD superfamily hydrolase involved in NAD metabolism Coenzyme metabolism 50914425 Pathogen - Protein G-related alpha 2M-binding protein M6_Spy1079 1 None None None 50914468 Common - ComE operon protein 3 M6_Spy1122 117 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 50913562 Pathogen - Hypothetical cytosolic protein M6_Spy0216 1 None None None 50913912 Common rpmE2 50S ribosomal protein L31 type B M6_Spy0566 164 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 50914497 Common - Phage DNA polymerase M6_Spy1151 46 COG3378 COG3378, Predicted ATPase General function prediction only 50913965 Common - dTDP-4-dehydrorhamnose reductase M6_Spy0619 178 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 50913445 Common rpsC 30S ribosomal protein S3 M6_Spy0099 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 50913435 Pathogen - hypothetical protein M6_Spy0089 1 None None None 50913497 Common - single-strand DNA-binding protein M6_Spy0151 185 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 50915088 Common - fructose-6-phosphate aldolase M6_Spy1742 110 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 50913818 Common rnc ribonuclease III M6_Spy0472 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 50914582 Common - RecT protein M6_Spy1236 24 COG3723 RecT, Recombinational DNA repair protein (RecE pathway) DNA replication, recombination, and repair 50914875 Common - Fructokinase M6_Spy1529 32 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 50913543 Common ulaD 3-keto-L-gulonate-6-phosphate decarboxylase M6_Spy0197 50 COG0269 SgbH, 3-hexulose-6-phosphate synthase and related proteins Carbohydrate transport and metabolism 50914461 Common queA S-adenosylmethionine:tRNA ribosyltransferase-isomerase M6_Spy1115 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 50915143 Common spxA transcriptional regulator Spx M6_Spy1797 49 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 50914533 Common - Formate transporter M6_Spy1187 95 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 50914622 Common - BipA M6_Spy1276 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 50913477 Common rpoB DNA-directed RNA polymerase subunit beta M6_Spy0131 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 50914687 Pathogen - unknown phage protein M6_Spy1341 1 None None None 50913922 Common - Enolase M6_Spy0576 170 COG0148 Eno, Enolase Carbohydrate transport and metabolism 50914467 Common holA DNA polymerase III subunit delta M6_Spy1121 47 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 50913982 Common infC translation initiation factor IF-3 M6_Spy0636 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 50914904 Common - unknown phage protein M6_Spy1558 2 None None None 50913467 Pathogen - hypothetical protein M6_Spy0121 1 None None None 50915076 Common - hypothetical protein M6_Spy1730 2 None None None 50913844 Common - Transcription antiterminator, BglG family M6_Spy0498 29 COG3711 BglG, Transcriptional antiterminator Transcription 50913490 Common - pyrroline-5-carboxylate reductase M6_Spy0144 213 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 50913802 Common - Daunorubicin resistance transmembrane protein M6_Spy0456 39 COG4587 COG4587, ABC-type uncharacterized transport system, permease component General function prediction only 50914548 Common - Phage infection protein M6_Spy1202 14 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 50913833 Common - hypothetical protein M6_Spy0487 3 None None None 50913575 Common - Hypothetical cytosolic protein M6_Spy0229 67 COG1636 COG1636, Uncharacterized protein conserved in bacteria Function unknown 50913357 Common - tRNA(Ile)-lysidine synthetase M6_Spy0011 205 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 50914576 Pathogen - unknown phage protein M6_Spy1230 1 None None None 50913380 Common - phage-related DNA polymerase M6_Spy0034 82 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 50915153 Common - HTH DNA-binding protein M6_Spy1807 3 COG3655 COG3655, Predicted transcriptional regulator Transcription 50914307 Common - hypothetical protein M6_Spy0961 17 COG3237 COG3237, Uncharacterized protein conserved in bacteria Function unknown 50914394 Common - PTS system, cellobiose-specific IIC component M6_Spy1048 38 COG1455 CelB, Phosphotransferase system cellobiose-specific component IIC Carbohydrate transport and metabolism 50913772 Pathogen - hypothetical protein M6_Spy0426 1 None None None 50914471 Common - Site-specific recombinase M6_Spy1125 98 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 50915009 Common cysS cysteinyl-tRNA synthetase M6_Spy1663 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 50914104 Common - NIF3-related protein M6_Spy0758 141 COG0327 COG0327, Uncharacterized conserved protein Function unknown 50914247 Pathogen - hypothetical protein M6_Spy0901 1 None None None 50914507 Common - Phage transcriptional repressor M6_Spy1161 9 COG2932 COG2932, Predicted transcriptional regulator Transcription 50914478 Common - prophage pi2 protein 40 M6_Spy1132 4 None None None 50915002 Common - Transcriptional regulator, Cro/CI family M6_Spy1656 50 COG1476 COG1476, Predicted transcriptional regulators Transcription 50914517 Common - Site-specific recombinase M6_Spy1171 17 None None None 50913484 Pathogen - ComG operon protein 5 M6_Spy0138 1 None None None 50914419 Common - 3-phosphoshikimate 1-carboxyvinyltransferase M6_Spy1073 233 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 161761328 Common rpsS 30S ribosomal protein S19 M6_Spy0097 243 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 161761305 Common nusA transcription elongation factor NusA M6_Spy1460 219 COG0195 NusA, Transcription elongation factor Transcription 161761319 Common tuf elongation factor Tu M6_Spy0529 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 50913928 Common - SagE M6_Spy0582 3 None None None 50914718 Common - ComF operon protein 3 M6_Spy1372 31 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 50914100 Common - adenine phosphoribosyltransferase M6_Spy0754 183 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 50914832 Common - Enoyl-[acyl-carrier protein] reductase (NADH) M6_Spy1486 137 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 50915091 Common - PTS system, cellobiose-specific IIB component M6_Spy1745 30 COG1440 CelA, Phosphotransferase system cellobiose-specific component IIB Carbohydrate transport and metabolism 50914091 Common - Glutathione S-transferase M6_Spy0745 14 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 50914778 Common glyS glycyl-tRNA synthetase subunit beta M6_Spy1432 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 50913432 Common - Hypothetical membrane associated protein M6_Spy0086 25 COG4642 COG4642, Uncharacterized protein conserved in bacteria Function unknown 161761312 Common rplL 50S ribosomal protein L7/L12 M6_Spy0814 202 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 50913938 Common - ATP synthase C chain M6_Spy0592 5 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 50915134 Common - Anaerobic ribonucleoside-triphosphate reductase activating protein M6_Spy1788 64 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 50913425 Common - phosphoribosylaminoimidazole carboxylase catalytic subunit M6_Spy0079 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 50915226 Common - ABC transporter, permease protein M6_Spy1880 11 COG4485 COG4485, Predicted membrane protein Function unknown 50913948 Pathogen - EpuA M6_Spy0602 1 None None None 161761296 Common tsf elongation factor Ts M6_Spy1780 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 50914667 Common - Shikimate 5-dehydrogenase M6_Spy1321 225 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 50913398 Pathogen - unknown phage protein M6_Spy0052 1 None None None 50913856 Common - hypothetical protein M6_Spy0510 3 None None None 50914680 Common - hypothetical protein M6_Spy1334 19 COG3538 COG3538, Uncharacterized conserved protein Function unknown 50913746 Pathogen - hypothetical protein M6_Spy0400 1 None None None 50913762 Common - Phosphohydrolase (MutT/nudix family protein) M6_Spy0416 44 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 50914153 Common - Succinate-semialdehyde dehydrogenase [NADP+] M6_Spy0807 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 50914786 Common - DegV family protein M6_Spy1440 43 COG1307 DegV, Uncharacterized protein conserved in bacteria Function unknown 50913716 Common metG methionyl-tRNA synthetase M6_Spy0370 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 50913407 Pathogen - unknown phage protein M6_Spy0061 1 None None None 50914007 Pathogen - hypothetical protein M6_Spy0661 1 None None None 50914185 Common - Glutamine amidotransferase, class I M6_Spy0839 122 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 50914660 Common - hypothetical protein M6_Spy1314 2 None None None 50914641 Common - Acetyltransferase M6_Spy1295 20 COG2153 ElaA, Predicted acyltransferase General function prediction only 50914557 Pathogen - unknown phage protein M6_Spy1211 1 None None None 50914037 Common - tRNA CCA-pyrophosphorylase M6_Spy0691 214 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 50913364 Common - ribose-phosphate pyrophosphokinase M6_Spy0018 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 50914707 Pathogen - unknown phage protein M6_Spy1361 1 None None None 50915055 Pathogen - SmeZ M6_Spy1709 2 None None None 50913569 Common - Integral membrane protein (Rhomboid family) M6_Spy0223 67 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 50915195 Common - Phage infection protein M6_Spy1849 31 COG1511 COG1511, Predicted membrane protein Function unknown 50914343 Common - unknown phage protein M6_Spy0997 48 COG5283 COG5283, Phage-related tail protein Function unknown 50914485 Common - ATP-dependent Clp protease proteolytic subunit M6_Spy1139 145 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 50913726 Pathogen - hypothetical protein M6_Spy0380 1 None None None 50914313 Pathogen - hypothetical protein M6_Spy0968 1 None None None 50915188 Pathogen - hypothetical protein M6_Spy1842 1 None None None 50913750 Common pyrH uridylate kinase M6_Spy0404 230 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 50913620 Common - ABC transporter-associated protein M6_Spy0274 182 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 50914561 Pathogen - Phage structural protein M6_Spy1215 1 None None None 50914367 Common - Phage transcriptional regulator, Cro/CI family M6_Spy1021 3 None None None 50914000 Common - Transcriptional regulators, LysR family M6_Spy0654 180 COG0583 LysR, Transcriptional regulator Transcription 50914564 Common - unknown phage protein M6_Spy1218 8 None None None 50914229 Common - oxaloacetate decarboxylase M6_Spy0883 174 COG5016 COG5016, Pyruvate/oxaloacetate carboxyltransferase Energy production and conversion 50914781 Common - Aldo/keto reductase family M6_Spy1435 188 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 50914887 Common - Streptodornase M6_Spy1541 6 None None None 50915176 Common - Hypothetical membrane spanning protein M6_Spy1830 49 COG1284 COG1284, Uncharacterized conserved protein Function unknown 50914401 Common - Nicotinamide mononucleotide transporter M6_Spy1055 9 COG3201 PnuC, Nicotinamide mononucleotide transporter Coenzyme metabolism 50913519 Common - V-type ATP synthase subunit I M6_Spy0173 41 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 50914145 Common - Hypothetical membrane spanning protein M6_Spy0799 119 COG2855 COG2855, Predicted membrane protein Function unknown 50913703 Common - DNA polymerase III subunit delta' M6_Spy0357 209 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 50915183 Common - Cadmium efflux system accessory protein M6_Spy1837 76 COG0640 ArsR, Predicted transcriptional regulators Transcription 50913611 Common - glyceraldehyde-3-phosphate dehydrogenase M6_Spy0265 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 50913513 Common - Acetate CoA-transferase alpha subunit M6_Spy0167 99 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 50914573 Pathogen - unknown phage protein M6_Spy1227 1 None None None 50913870 Common - Glutathione peroxidase M6_Spy0524 114 COG0386 BtuE, Glutathione peroxidase Posttranslational modification, protein turnover, chaperones 50913366 Common - DNA integration/recombination/invertion protein M6_Spy0020 142 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 50915046 Common prmA ribosomal protein L11 methyltransferase M6_Spy1700 180 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 50914487 Common - Terminase large subunit M6_Spy1141 46 COG4626 COG4626, Phage terminase-like protein, large subunit General function prediction only 50914757 Pathogen - hypothetical protein M6_Spy1410 1 None None None 50913354 Common - DivIC M6_Spy0008 6 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 50913391 Pathogen - unknown phage protein M6_Spy0045 1 None None None 50915117 Common - Formate--tetrahydrofolate ligase M6_Spy1771 89 COG2759 MIS1, Formyltetrahydrofolate synthetase Nucleotide transport and metabolism 50914937 Common - hypothetical protein M6_Spy1591 107 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 50913675 Common - glutamate racemase M6_Spy0329 189 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 50913984 Common rplT 50S ribosomal protein L20 M6_Spy0638 213 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 50914844 Common - Hypothetical membrane spanning protein M6_Spy1498 17 COG2261 COG2261, Predicted membrane protein Function unknown 50914837 Common - DnaJ M6_Spy1491 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 50913470 Common - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase M6_Spy0124 11 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 50913910 Common - Transcriptional regulator, GntR family M6_Spy0564 123 COG2188 PhnF, Transcriptional regulators Transcription 50914226 Common - Smf protein M6_Spy0880 211 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 50914454 Common prsA foldase protein PrsA M6_Spy1108 12 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 50914924 Common - Exodeoxyribonuclease V alpha chain M6_Spy1578 139 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 50914861 Common - Cobalt transport protein M6_Spy1515 15 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 50915069 Common - Immunogenic secreted protein M6_Spy1723 9 COG3942 COG3942, Surface antigen General function prediction only 50913786 Common secG preprotein translocase subunit SecG M6_Spy0440 1 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 50913886 Common - PTS system, N-acetylgalactosamine-specific IID component M6_Spy0540 40 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 50913810 Common - Glycerol uptake facilitator protein M6_Spy0464 133 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 50913688 Common - SAM-dependent methyltransferase M6_Spy0342 29 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 50913804 Common - Dihydroxyacetone kinase M6_Spy0458 77 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 50914716 Pathogen - hypothetical protein M6_Spy1370 1 None None None 50914745 Common - Hypothetical cytosolic protein M6_Spy1399 11 COG4474 COG4474, Uncharacterized protein conserved in bacteria Function unknown 50913500 Common hslO Hsp33-like chaperonin M6_Spy0154 132 COG1281 COG1281, Disulfide bond chaperones of the HSP33 family Posttranslational modification, protein turnover, chaperones 50914513 Common - hypothetical protein M6_Spy1167 4 None None None 50914209 Common glyA serine hydroxymethyltransferase M6_Spy0863 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 50914892 Pathogen - unknown phage protein M6_Spy1546 1 None None None 50914868 Common - Putative Fe3+-siderophore transport protein M6_Spy1522 34 COG4886 COG4886, Leucine-rich repeat (LRR) protein Function unknown 50913616 Common uppP undecaprenyl pyrophosphate phosphatase M6_Spy0270 201 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 50913877 Common - Factor essential for expression of methicillin resistance M6_Spy0531 12 COG2348 COG2348, Uncharacterized protein involved in methicillin resistance Defense mechanisms 50915167 Pathogen - unknown phage protein M6_Spy1821 1 None None None 50914163 Pathogen - hypothetical protein M6_Spy0817 1 None None None 50913795 Common - NAD(P)H-dependent quinone reductase M6_Spy0449 90 COG0778 NfnB, Nitroreductase Energy production and conversion 50913882 Common - Hypothetical cytosolic protein M6_Spy0535 2 COG4506 COG4506, Uncharacterized protein conserved in bacteria Function unknown 50914309 Pathogen - Small integral membrane protein M6_Spy0963 1 COG5547 COG5547, Small integral membrane protein Function unknown 50913411 Common - Phage-associated cell wall hydrolase M6_Spy0065 67 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 50914932 Common - NorA M6_Spy1586 139 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 50914598 Common xseB exodeoxyribonuclease VII small subunit M6_Spy1252 83 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 50914521 Common - COME operon protein 1 M6_Spy1175 98 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 50913895 Common - Beta-phosphoglucomutase M6_Spy0549 176 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 50914074 Common - DNA topoisomerase IV subunit B M6_Spy0728 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 50914265 Common - hypothetical protein M6_Spy0919 105 COG2110 COG2110, Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 General function prediction only 50913478 Common - DNA-directed RNA polymerase subunit beta' M6_Spy0132 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 50913541 Common - PTS system, 3-keto-L-gulonate specific IIB component M6_Spy0195 29 COG3414 SgaB, Phosphotransferase system, galactitol-specific IIB component Carbohydrate transport and metabolism 50914980 Common - Transcriptional regulatory protein M6_Spy1634 162 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 50914230 Pathogen - Hypothetical membrane associated protein M6_Spy0884 1 None None None 50914996 Pathogen - Hypothetical cytosolic protein M6_Spy1650 1 None None None 50914909 Common - Magnesium and cobalt transport protein corA M6_Spy1563 78 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 50914974 Common - Glycerate kinase M6_Spy1628 81 COG1929 COG1929, Glycerate kinase Carbohydrate transport and metabolism 50913842 Common - Cell division protein ftsY M6_Spy0496 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 50913588 Common rpmH 50S ribosomal protein L34 M6_Spy0242 6 None None None 50914381 Pathogen - hypothetical protein M6_Spy1035 1 None None None 50914386 Common - DltD precursor M6_Spy1040 12 COG3966 DltD, Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) Cell envelope biogenesis, outer membrane 50914365 Pathogen - unknown phage protein M6_Spy1019 1 None None None 50914040 Common - peptide deformylase M6_Spy0694 168 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 50914187 Common - Hypothetical cytosolic protein M6_Spy0841 7 None None None 50914877 Common - PTS system, sucrose-specific IIABC component M6_Spy1531 60 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 50914047 Common - Phosphomevalonate kinase M6_Spy0701 14 COG1577 ERG12, Mevalonate kinase Lipid metabolism 50913890 Common - PTS system, N-acetylgalactosamine-specific IIA component M6_Spy0544 54 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 50914322 Common pfkA 6-phosphofructokinase M6_Spy0976 157 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 50914678 Common - Hyaluronoglucosaminidase M6_Spy1332 13 None None None 50914052 Common - Dihydrofolate reductase M6_Spy0706 144 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 50913525 Common - V-type ATP synthase subunit B M6_Spy0179 247 COG1156 NtpB, Archaeal/vacuolar-type H+-ATPase subunit B Energy production and conversion 50914858 Common - ATP-dependent DNA helicase M6_Spy1512 219 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 50914195 Common - Short chain dehydrogenase M6_Spy0849 237 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 50913732 Common - Glucosamine-1-phosphate acetyltransferase M6_Spy0386 236 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 50914036 Common - DegV family protein M6_Spy0690 48 COG1307 DegV, Uncharacterized protein conserved in bacteria Function unknown 50914634 Common coaD phosphopantetheine adenylyltransferase M6_Spy1288 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 50913382 Common - hypothetical protein M6_Spy0036 14 None None None 50914335 Common - Holin M6_Spy0989 4 COG4824 COG4824, Phage-related holin (Lysis protein) General function prediction only 50914356 Pathogen - unknown phage protein M6_Spy1010 1 None None None 50914650 Common - Thiol:disulfide interchange protein M6_Spy1304 110 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 50913440 Common rplD 50S ribosomal protein L4 M6_Spy0094 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 50913556 Common tgt queuine tRNA-ribosyltransferase M6_Spy0210 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 50913759 Common - hypothetical protein M6_Spy0413 182 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 50914655 Pathogen - hypothetical protein M6_Spy1309 1 None None None 50913957 Common - ATP-dependent nuclease subunit B M6_Spy0611 27 COG3857 AddB, ATP-dependent nuclease, subunit B DNA replication, recombination, and repair 50914504 Common - Type II restriction-modification system restriction subunit M6_Spy1158 5 None None None 50914647 Common - Two-component sensor kinase YesM M6_Spy1301 108 COG2972 COG2972, Predicted signal transduction protein with a C-terminal ATPase domain Signal transduction mechanisms 50914059 Common - phosphopentomutase M6_Spy0713 70 COG1015 DeoB, Phosphopentomutase Carbohydrate transport and metabolism 50914988 Common - PTS system, lactose-specific IIBC component M6_Spy1642 37 COG1455 CelB, Phosphotransferase system cellobiose-specific component IIC Carbohydrate transport and metabolism 50914217 Common - Sortase M6_Spy0871 17 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 50914117 Common - ABC transporter ATP-binding protein M6_Spy0771 249 COG1101 PhnK, ABC-type uncharacterized transport system, ATPase component General function prediction only 50914954 Common - Transcriptional regulator, MerR family M6_Spy1608 44 COG0789 SoxR, Predicted transcriptional regulators Transcription 50914855 Common - L-asparaginase M6_Spy1509 139 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 50915035 Common - Glucan 1,6-alpha-glucosidase M6_Spy1689 155 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 50914734 Common - hypothetical protein M6_Spy1388 76 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 50913652 Common gidB glucose-inhibited division protein B M6_Spy0306 204 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 50915022 Common - Putative transcriptional regulator M6_Spy1676 1 None None None 50914693 Common - Phage infection protein M6_Spy1347 17 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 50914808 Common trmB tRNA (guanine-N(7))-methyltransferase M6_Spy1462 178 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 50914082 Pathogen - hypothetical protein M6_Spy0736 2 None None None 50913418 Common - Phosphoribosylformylglycinamidine synthase M6_Spy0072 233 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 50914640 Common - ornithine carbamoyltransferase M6_Spy1294 234 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 50914612 Common - RNA binding protein M6_Spy1266 31 COG2302 COG2302, Uncharacterized conserved protein, contains S4-like domain Function unknown 50914619 Common murG N-acetylglucosaminyl transferase M6_Spy1273 208 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 50914681 Common - Alpha-mannosidase M6_Spy1335 44 COG0383 AMS1, Alpha-mannosidase Carbohydrate transport and metabolism 50915010 Pathogen - hypothetical protein M6_Spy1664 1 None None None 50914071 Common - uracil-DNA glycosylase M6_Spy0725 129 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 50915008 Common - hypothetical protein M6_Spy1662 38 COG1939 COG1939, Uncharacterized protein conserved in bacteria Function unknown 50913849 Pathogen - Hypothetical membrane spanning protein M6_Spy0503 1 None None None 50914006 Common - carbamoyl phosphate synthase small subunit M6_Spy0660 237 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 50913471 Common - Transcriptional regulator, MarR family M6_Spy0125 8 COG1846 MarR, Transcriptional regulators Transcription 50913789 Common - Glutaminyl-peptide cyclotransferase M6_Spy0443 22 COG3823 COG3823, Glutamine cyclotransferase Posttranslational modification, protein turnover, chaperones 50913547 Common - Transcription antiterminator, BglG family M6_Spy0201 33 COG3711 BglG, Transcriptional antiterminator Transcription 50913409 Pathogen - unknown phage protein M6_Spy0063 1 None None None 50913430 Common ruvB Holliday junction DNA helicase B M6_Spy0084 224 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 50914017 Common - Hypothetical cytosolic protein M6_Spy0671 19 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 50914010 Common - ABC transporter ATP-binding protein M6_Spy0664 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 50914505 Common - Type II restriction-modification system restriction subunit M6_Spy1159 48 COG1401 McrB, GTPase subunit of restriction endonuclease Defense mechanisms 50914351 Pathogen - unknown phage protein M6_Spy1005 1 None None None 50913596 Common - N-acetylmannosamine kinase M6_Spy0250 129 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 50914574 Pathogen - unknown phage protein M6_Spy1228 1 None None None 50915078 Common prsA foldase protein PrsA M6_Spy1732 11 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 50913934 Common - Endonuclease/Exonuclease/phosphatase family protein M6_Spy0588 40 COG2374 COG2374, Predicted extracellular nuclease General function prediction only 50913538 Common - Cystathionine beta-lyase M6_Spy0192 207 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 50914173 Common - Spermidine/putrescine-binding protein M6_Spy0827 133 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 50914476 Common - unknown phage protein M6_Spy1130 27 COG5280 COG5280, Phage-related minor tail protein Function unknown 50914903 Pathogen - unknown phage protein M6_Spy1557 1 None None None 161761318 Common pheS phenylalanyl-tRNA synthetase subunit alpha M6_Spy0604 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 50913868 Common - Integral membrane protein M6_Spy0522 11 None None None 50914631 Common - Ribose operon repressor M6_Spy1285 105 COG1609 PurR, Transcriptional regulators Transcription 50915054 Common - topology modulation protein M6_Spy1708 35 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 50914447 Common - Transposase M6_Spy1101 68 None None None 50914211 Common - Antigen M6_Spy0865 8 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 50914976 Common - Type I restriction-modification system specificity subunit M6_Spy1630 80 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 50913967 Common - alpha-L-Rha alpha-1,3-L-rhamnosyltransferase M6_Spy0621 125 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 50913482 Common - ComG operon protein 3 M6_Spy0136 3 COG4537 ComGC, Competence protein ComGC Intracellular trafficking and secretion 50913559 Common - Metal-dependent hydrolase M6_Spy0213 75 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 50913817 Common - Zn-dependent hydrolase (beta-lactamase superfamily) M6_Spy0471 59 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 50913656 Common - Response regulator CsrR M6_Spy0310 226 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 50914254 Common guaA bifunctional GMP synthase/glutamine amidotransferase protein M6_Spy0908 239 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 50914704 Pathogen - unknown phage protein M6_Spy1358 1 None None None 50914605 Common - Arginine transport system permease protein M6_Spy1259 175 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 50915093 Common - Sorbitol operon regulator M6_Spy1747 67 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 50913926 Pathogen - Streptolysin S biosynthesis protein M6_Spy0580 2 None None None 50913971 Common - alpha-L-Rha alpha-1,2-L-rhamnosyltransferase M6_Spy0625 23 COG3754 RgpF, Lipopolysaccharide biosynthesis protein Cell envelope biogenesis, outer membrane 50914200 Common - xanthine phosphoribosyltransferase M6_Spy0854 35 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 50914431 Pathogen - hypothetical protein M6_Spy1085 1 None None None 50914134 Common - Phosphoglucosamine mutase M6_Spy0788 243 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 50914164 Common - dihydrofolate synthase M6_Spy0818 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 50914739 Common - 3-hydroxybutyrate dehydrogenase M6_Spy1393 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 50914851 Common - transcriptional repressor CodY M6_Spy1505 20 COG4465 CodY, Pleiotropic transcriptional repressor Transcription 50914325 Common - ABC transporter ATP-binding protein M6_Spy0979 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 50913857 Common - hypothetical protein M6_Spy0511 1 None None None 50913823 Common - hypothetical protein M6_Spy0477 44 COG1478 COG1478, Uncharacterized conserved protein Function unknown 50914552 Common - Minor tail protein GP26 M6_Spy1206 26 COG5412 COG5412, Phage-related protein Function unknown 161761298 Common groES co-chaperonin GroES M6_Spy1761 171 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 50914358 Common - Phage Terminase Small Subunit M6_Spy1012 6 COG3747 COG3747, Phage terminase, small subunit DNA replication, recombination, and repair 50915136 Common - Mvi M6_Spy1790 72 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 50914412 Common - Transporter, MFS superfamily M6_Spy1066 162 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 50914717 Common - Ribosome-associated factor Y M6_Spy1371 171 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 50913744 Common - Transposase M6_Spy0398 27 COG5433 COG5433, Transposase DNA replication, recombination, and repair 50914948 Common - O-sialoglycoprotein endopeptidase M6_Spy1602 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 50913881 Common - dGTP triphosphohydrolase M6_Spy0536 87 COG1078 COG1078, HD superfamily phosphohydrolases General function prediction only 50914829 Common - 3-oxoacyl-(acyl carrier protein) synthase II M6_Spy1483 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 50914311 Common - Integral membrane protein M6_Spy0965 42 COG2261 COG2261, Predicted membrane protein Function unknown 50914438 Common - Polysaccharide deacetylase family protein M6_Spy1092 102 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 50913386 Common - Phage transcriptional activator M6_Spy0040 5 None None None 50914391 Common - Glutamine transport system permease protein M6_Spy1045 191 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 50914530 Common - UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase M6_Spy1184 208 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 50913648 Common - Branched-chain amino acid transport system carrier protein M6_Spy0302 50 COG1114 BrnQ, Branched-chain amino acid permeases Amino acid transport and metabolism 50913981 Common cmk cytidylate kinase M6_Spy0635 205 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 50914029 Common - Autolysin M6_Spy0683 58 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 50914240 Common - citrate lyase subunit gamma M6_Spy0894 25 COG3052 CitD, Citrate lyase, gamma subunit Energy production and conversion 50915042 Common - hypothetical protein M6_Spy1696 33 COG1780 NrdI, Protein involved in ribonucleotide reduction Nucleotide transport and metabolism 50914238 Common - Oxaloacetate decarboxylase beta chain M6_Spy0892 56 COG1883 OadB, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit Energy production and conversion 50913863 Common - Hydrolase (HAD superfamily) M6_Spy0517 99 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 50914588 Common - DNA integration/recombination/invertion protein M6_Spy1242 103 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 50915071 Common - Two-component response regulator M6_Spy1725 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 50913885 Common - Oligohyaluronate lyase M6_Spy0539 16 None None None 50914277 Common - Nucleoside-binding protein M6_Spy0931 96 COG1744 Med, Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein General function prediction only 50915139 Common - Hypothetical membrane spanning protein M6_Spy1793 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 50913993 Common - Cysteine desulfhydrase M6_Spy0647 238 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 50913362 Pathogen - hypothetical protein M6_Spy0016 1 None None None 50914064 Common - Transcriptional regulators, LysR family M6_Spy0718 175 COG0583 LysR, Transcriptional regulator Transcription 50914690 Pathogen - unknown phage protein M6_Spy1344 1 None None None 50914453 Common alaS alanyl-tRNA synthetase M6_Spy1107 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 50914396 Common - PTS system, cellobiose-specific IIA component M6_Spy1050 32 COG1447 CelC, Phosphotransferase system cellobiose-specific component IIA Carbohydrate transport and metabolism 50913453 Common rpsH 30S ribosomal protein S8 M6_Spy0107 248 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 50913695 Common - Ferrichrome-binding protein M6_Spy0349 14 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 50914389 Common - D-alanine--D-alanyl carrier protein ligase M6_Spy1043 222 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 50915082 Pathogen - hypothetical protein M6_Spy1736 1 None None None 50914376 Common - 4-alpha-glucanotransferase M6_Spy1030 117 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 50914725 Common - Two-component sensor protein yvqE M6_Spy1379 138 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 50913835 Common - Plasmid stabilization system antitoxin protein M6_Spy0488 10 COG3077 RelB, DNA-damage-inducible protein J DNA replication, recombination, and repair 50913752 Common - S1 RNA binding domain M6_Spy0406 42 COG2996 COG2996, Uncharacterized protein conserved in bacteria Function unknown 50914624 Common - Glucokinase M6_Spy1278 161 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 50913422 Common purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase M6_Spy0076 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 50913494 Common - Hypothetical membrane associated protein M6_Spy0148 1 None None None 50914158 Common - Transposase M6_Spy0812 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 50914583 Pathogen - unknown phage protein M6_Spy1237 1 None None None 50915145 Common - competence damage-inducible protein A M6_Spy1799 212 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 50914599 Common xseA exodeoxyribonuclease VII large subunit M6_Spy1253 205 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 50914535 Common - Transcriptional regulator, biotin repressor family M6_Spy1189 16 COG1827 COG1827, Predicted small molecule binding protein (contains 3H domain) General function prediction only 50914443 Common - ribonucleotide-diphosphate reductase subunit alpha M6_Spy1097 217 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 50914114 Common - ABC transporter substrate-binding protein M6_Spy0768 54 COG2984 COG2984, ABC-type uncharacterized transport system, periplasmic component General function prediction only 50913958 Common - ATP-dependent nuclease subunit A M6_Spy0612 229 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 50913374 Pathogen - unknown phage protein M6_Spy0028 1 None None None 50914771 Common - trans-acting positive regulator M6_Spy1425 4 COG3711 BglG, Transcriptional antiterminator Transcription 50913946 Common - Hypothetical membrane associated protein M6_Spy0600 1 None None None 50914371 Pathogen - unknown phage protein M6_Spy1025 1 None None None 50915155 Pathogen - unknown phage protein M6_Spy1809 1 None None None 50914223 Common - Hypothetical cytosolic protein M6_Spy0877 6 None None None 50914475 Common - unknown phage protein M6_Spy1129 2 COG4722 COG4722, Phage-related protein Function unknown 50913628 Common - OppC M6_Spy0282 219 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 50913807 Common - Dihydroxyacetone kinase M6_Spy0461 77 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 161761302 Common - aminotransferase AlaT M6_Spy1506 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 50914878 Common - Sucrose-6-phosphate hydrolase M6_Spy1532 52 COG1621 SacC, Beta-fructosidases (levanase/invertase) Carbohydrate transport and metabolism 50913572 Common - Transcriptional regulator, MarR family M6_Spy0226 11 COG1846 MarR, Transcriptional regulators Transcription 50913822 Common - Hypothetical cytosolic protein M6_Spy0476 7 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 50915130 Common - Trehalose operon transcriptional repressor M6_Spy1784 101 COG2188 PhnF, Transcriptional regulators Transcription 50913723 Pathogen - Hypothetical membrane associated protein M6_Spy0377 1 None None None 50913448 Common rpsQ 30S ribosomal protein S17 M6_Spy0102 222 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 50914262 Common - Formate--tetrahydrofolate ligase M6_Spy0916 89 COG2759 MIS1, Formyltetrahydrofolate synthetase Nucleotide transport and metabolism 50913918 Common - DNA gyrase related protein M6_Spy0572 13 COG0546 Gph, Predicted phosphatases General function prediction only 50913634 Common - Putative lipase M6_Spy0288 43 COG2179 COG2179, Predicted hydrolase of the HAD superfamily General function prediction only 50913460 Common adk adenylate kinase M6_Spy0114 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 50914797 Common - Lactose phosphotransferase system repressor M6_Spy1451 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 50914318 Common - D-fructose-6-phosphate amidotransferase M6_Spy0972 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 50914790 Common - tagatose 1,6-diphosphate aldolase M6_Spy1444 26 COG3684 LacD, Tagatose-1,6-bisphosphate aldolase Carbohydrate transport and metabolism 50913542 Common - PTS system, 3-keto-L-gulonate specific IIA component M6_Spy0196 41 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 50913564 Pathogen - Hypothetical membrane associated protein M6_Spy0218 1 None None None 50914544 Pathogen - N-acetylmuramoyl-L-alanine amidase M6_Spy1198 2 None None None 50914946 Common - Transcriptional regulator, GntR family M6_Spy1600 69 COG2188 PhnF, Transcriptional regulators Transcription 50914305 Common - Transcriptional regulator, GntR family M6_Spy0959 20 COG0490 COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels Inorganic ion transport and metabolism 50913713 Common - Lactocepin M6_Spy0367 45 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 50913441 Common rplW 50S ribosomal protein L23 M6_Spy0095 187 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 50914380 Common - MalG M6_Spy1034 162 COG3833 MalG, ABC-type maltose transport systems, permease component Carbohydrate transport and metabolism 50914424 Common - Transposase M6_Spy1078 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 50913730 Common - NAD-dependent oxidoreductase M6_Spy0384 162 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 50914197 Common - Glycine betaine transport ATP-binding protein M6_Spy0851 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 50914175 Common - DpiB M6_Spy0829 41 COG3290 CitA, Signal transduction histidine kinase regulating citrate/malate metabolism Signal transduction mechanisms 50914121 Common - ABC transporter ATP-binding protein M6_Spy0775 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 50913528 Pathogen - Hypothetical membrane associated protein M6_Spy0182 1 None None None 50913935 Common - Hypothetical membrane spanning protein M6_Spy0589 16 COG4708 COG4708, Predicted membrane protein Function unknown 50914630 Pathogen - hypothetical protein M6_Spy1284 1 None None None 50915033 Common - Pullulanase M6_Spy1688 144 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 50915017 Common - PTS system IIB component M6_Spy1671 20 COG3414 SgaB, Phosphotransferase system, galactitol-specific IIB component Carbohydrate transport and metabolism 50914312 Common - DNA helicase II M6_Spy0966 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 50914093 Pathogen - hypothetical protein M6_Spy0747 1 None None None 50913496 Common - tRNA binding domain protein M6_Spy0150 199 COG0073 ARC1, EMAP domain General function prediction only 50913978 Common - Pore forming protein ebsA M6_Spy0632 2 None None None 50914337 Pathogen - unknown phage protein M6_Spy0991 1 None None None 50915025 Common - Transcriptional regulator, MarR family M6_Spy1679 99 COG1846 MarR, Transcriptional regulators Transcription 50914228 Common - tRNA (uracil-5-)-methyltransferase Gid M6_Spy0882 193 COG1206 Gid, NAD(FAD)-utilizing enzyme possibly involved in translation Translation, ribosomal structure and biogenesis 50913462 Common rpmJ 50S ribosomal protein L36 M6_Spy0116 139 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 50914260 Common - Anaerobic ribonucleoside-triphosphate reductase M6_Spy0914 42 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 50914344 Pathogen - unknown phage protein M6_Spy0998 1 None None None 50915067 Pathogen - hypothetical protein M6_Spy1721 1 None None None 50915024 Common - Oxidoreductase M6_Spy1678 93 COG0431 COG0431, Predicted flavoprotein General function prediction only 50915159 Pathogen - unknown phage protein M6_Spy1813 1 None None None 50914128 Common - Hyaluronate lyase precursor M6_Spy0782 12 None None None 50913840 Common - Hydrolase (HAD superfamily) M6_Spy0494 109 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 50914952 Common - Zn-dependent hydrolase M6_Spy1606 161 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 50915157 Pathogen - unknown phage protein M6_Spy1811 1 None None None 50914382 Common - Transposase M6_Spy1036 7 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 50914938 Common - Transcriptional regulator, MerR family M6_Spy1592 3 None None None 50915212 Common - Zinc protease M6_Spy1866 90 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 50914818 Common - Hydrolase (HAD superfamily) M6_Spy1472 113 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 50914034 Common - Nucleoside diphosphate kinase M6_Spy0688 2 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 50914824 Common - acetyl-CoA carboxylase subunit alpha M6_Spy1478 178 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 50914637 Common - carbamate kinase M6_Spy1291 65 COG0549 ArcC, Carbamate kinase Amino acid transport and metabolism 50914732 Common - DNA-directed RNA polymerase subunit omega M6_Spy1386 12 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 50913531 Common nusG transcription antitermination protein NusG M6_Spy0185 215 COG0250 NusG, Transcription antiterminator Transcription 50914249 Common - Phage transcriptional repressor M6_Spy0903 14 COG2932 COG2932, Predicted transcriptional regulator Transcription 50914986 Pathogen - Lantibiotic salivaricin A M6_Spy1640 1 None None None 50914299 Common - Integral membrane protein M6_Spy0953 9 COG4129 COG4129, Predicted membrane protein Function unknown 50914968 Common - hypothetical protein M6_Spy1622 16 COG4475 COG4475, Uncharacterized protein conserved in bacteria Function unknown 50914962 Common - fructose-bisphosphate aldolase M6_Spy1616 178 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 50915044 Common - PTS system, glucose-specific IIABC component M6_Spy1698 60 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 50914695 Common - Phage endopeptidase M6_Spy1349 5 COG4926 PblB, Phage-related protein Function unknown 50914272 Common - Integral membrane protein M6_Spy0926 5 COG4684 COG4684, Predicted membrane protein Function unknown 50914971 Common truA tRNA pseudouridine synthase A M6_Spy1625 237 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 50914547 Pathogen - unknown phage protein M6_Spy1201 1 None None None 50914267 Common - Luciferase-like monooxygenase M6_Spy0921 105 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 50915185 Common - FtsK/SpoIIIE family M6_Spy1839 9 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 50915111 Common - Peroxiredoxin M6_Spy1765 217 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 50915205 Common - L-serine dehydratase alpha subunit M6_Spy1859 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 50914671 Common - Hypothetical membrane spanning protein M6_Spy1325 4 COG5578 COG5578, Predicted integral membrane protein Function unknown 50914809 Common - Phosphotransferase enzyme family M6_Spy1463 11 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 50914899 Common - Minor tail protein GP26 M6_Spy1553 27 COG5412 COG5412, Phage-related protein Function unknown 50914020 Common rimM 16S rRNA-processing protein M6_Spy0674 134 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 50913696 Common - FhuC M6_Spy0350 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 50914306 Common - General stress protein, Gls24 family M6_Spy0960 35 COG1302 COG1302, Uncharacterized protein conserved in bacteria Function unknown 50913737 Common - Iron-dependent repressor M6_Spy0391 95 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 50914233 Common - 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase M6_Spy0887 45 COG1767 CitG, Triphosphoribosyl-dephospho-CoA synthetase Coenzyme metabolism 50913956 Common - Neutral zinc metallopeptidase family M6_Spy0610 88 COG2321 COG2321, Predicted metalloprotease General function prediction only 50913673 Common - Integral membrane protein M6_Spy0327 141 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 50913508 Pathogen - hypothetical protein M6_Spy0162 1 None None None 50914911 Common rpsR 30S ribosomal protein S18 M6_Spy1565 215 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 50914143 Pathogen - Collagen-like surface protein M6_Spy0797 1 None None None 50914666 Common - SAM-dependent methyltransferase M6_Spy1320 142 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 50914409 Common - Transposase M6_Spy1063 2 None None None 50913416 Common - acyl carrier protein M6_Spy0070 3 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 50914542 Pathogen - SpeC M6_Spy1196 2 None None None 50913511 Common - Transcriptional regulators, LysR family M6_Spy0165 164 COG0583 LysR, Transcriptional regulator Transcription 50914046 Common - Diphosphomevalonate decarboxylase M6_Spy0700 27 COG3407 MVD1, Mevalonate pyrophosphate decarboxylase Lipid metabolism 50914283 Common - CiaR M6_Spy0937 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 50915128 Common - Trehalose-6-phosphate hydrolase M6_Spy1782 162 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 50913809 Common - Dihydroxyacetone kinase phosphotransfer protein M6_Spy0463 36 COG3412 COG3412, Uncharacterized protein conserved in bacteria Function unknown 50914866 Common - Ferrichrome transport system permease protein M6_Spy1520 191 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 50914610 Common ileS isoleucyl-tRNA synthetase M6_Spy1264 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 50914712 Pathogen - unknown phage protein M6_Spy1366 1 None None None 50913605 Common - CMP-binding factor M6_Spy0259 46 COG3481 COG3481, Predicted HD-superfamily hydrolase General function prediction only 50913351 Common - peptidyl-tRNA hydrolase M6_Spy0005 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 161761307 Common - S-ribosylhomocysteinase M6_Spy1395 55 COG1854 LuxS, LuxS protein involved in autoinducer AI2 synthesis Signal transduction mechanisms 50913658 Common - hypothetical protein M6_Spy0312 177 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 50914617 Common - Cell division protein ftsA M6_Spy1271 185 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 50913767 Common - Transposase M6_Spy0421 2 None None None 50914766 Common - ABC transporter permease protein M6_Spy1420 3 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 50914841 Common - N-acetylmuramoyl-L-alanine amidase M6_Spy1495 18 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 50913668 Pathogen - Transposase M6_Spy0322 1 None None None 50913473 Common - High-affinity zinc uptake system membrane protein M6_Spy0127 191 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 50913907 Common - Hypothetical cytosolic protein M6_Spy0561 54 COG1481 COG1481, Uncharacterized protein conserved in bacteria Function unknown 50913781 Common coaE dephospho-CoA kinase M6_Spy0435 197 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 50915232 Common - Chromosome partitioning protein M6_Spy1886 188 COG1475 Spo0J, Predicted transcriptional regulators Transcription 50914108 Common - dTDP-glucose 4,6-dehydratase M6_Spy0762 231 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 50914572 Pathogen - unknown phage protein M6_Spy1226 1 None None None 50915227 Common - Transposase M6_Spy1881 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 50914192 Common ppnK inorganic polyphosphate/ATP-NAD kinase M6_Spy0846 238 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 50915056 Common - Dipeptide-binding protein M6_Spy1710 202 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 50913812 Common - Acetyl-CoA acetyltransferase M6_Spy0466 169 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 50914593 Pathogen - hypothetical protein M6_Spy1247 1 None None None 50913554 Common - Integral membrane protein M6_Spy0208 7 COG5523 COG5523, Predicted integral membrane protein Function unknown 50913586 Common - Jag M6_Spy0240 62 COG1847 Jag, Predicted RNA-binding protein General function prediction only 50913369 Common - Phage transcriptional regulator, Cro/CI family M6_Spy0023 11 None None None 50914203 Common - 4-oxalocrotonate tautomerase M6_Spy0857 14 COG1942 COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog General function prediction only 50914669 Common - Two-component response regulator yesN M6_Spy1323 220 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 50915105 Common - Transcriptional regulator, MutR family M6_Spy1759 4 COG1396 HipB, Predicted transcriptional regulators Transcription 50914889 Common - Abortive infection phage resistance protein M6_Spy1543 35 COG4823 AbiF, Abortive infection bacteriophage resistance protein Defense mechanisms 50914256 Common - ABC transporter ATP-binding protein M6_Spy0910 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 50915198 Common - hypothetical protein M6_Spy1852 2 COG4466 Veg, Uncharacterized protein conserved in bacteria Function unknown 50914702 Pathogen - Minor capsid protein M6_Spy1356 1 None None None 50914901 Common - unknown phage protein M6_Spy1555 4 None None None 50915059 Common - Dipeptide transport ATP-binding protein dppD M6_Spy1713 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 50913749 Common - Transposase M6_Spy0403 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 50914565 Pathogen - unknown phage protein M6_Spy1219 1 None None None 50913953 Common - hypothetical protein M6_Spy0607 6 COG3272 COG3272, Uncharacterized conserved protein Function unknown 50914526 Common - ATP-dependent RNA helicase M6_Spy1180 240 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 50913480 Common - ComG operon protein 1 M6_Spy0134 211 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 50914098 Common - Short chain dehydrogenase M6_Spy0752 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 50914410 Common - Ribosomal small subunit pseudouridine synthase A M6_Spy1064 207 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 50913973 Common - Glycosyltransferase M6_Spy0627 182 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 50914978 Pathogen - hypothetical protein M6_Spy1633 1 None None None 50915040 Common - GTP pyrophosphokinase M6_Spy1694 207 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 50914378 Common - Maltose/maltodextrin-binding protein M6_Spy1032 66 COG2182 MalE, Maltose-binding periplasmic proteins/domains Carbohydrate transport and metabolism 50913850 Common - transcription accessory protein M6_Spy0504 209 COG2183 Tex, Transcriptional accessory protein Transcription 50914132 Common - Hypothetical membrane spanning protein M6_Spy0786 67 COG1624 COG1624, Uncharacterized conserved protein Function unknown 50915161 Common - unknown phage protein M6_Spy1815 2 None None None 50913360 Common - Transposase M6_Spy0014 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 50914202 Common - Iron-sulfur cluster assembly/repair protein M6_Spy0856 129 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 50915047 Common - hypothetical protein M6_Spy1701 4 None None None 50914708 Pathogen - unknown phage protein M6_Spy1362 1 None None None 50913540 Common ulaA ascorbate-specific PTS system enzyme IIC M6_Spy0194 36 COG3037 SgaT, Uncharacterized protein conserved in bacteria Function unknown 50914827 Common fabZ (3R)-hydroxymyristoyl-(acyl carrier protein) dehydratase M6_Spy1481 187 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 50915125 Common rpsB 30S ribosomal protein S2 M6_Spy1779 222 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 50913721 Pathogen - hypothetical protein M6_Spy0375 1 None None None 50914414 Common - Thioesterase superfamily protein M6_Spy1068 37 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 50914645 Common - hypothetical protein M6_Spy1299 34 COG3382 COG3382, Uncharacterized conserved protein Function unknown 50913402 Common - unknown phage protein M6_Spy0056 38 COG5412 COG5412, Phage-related protein Function unknown 50914420 Common - Ribonuclease BN M6_Spy1074 35 COG1295 Rbn, Predicted membrane protein Function unknown 50913367 Pathogen - unknown phage protein M6_Spy0021 1 None None None 50913489 Pathogen - hypothetical protein M6_Spy0143 1 None None None 50913711 Common - Exodeoxyribonuclease III M6_Spy0365 194 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 50914069 Common - Cystine-binding protein M6_Spy0723 169 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 50913742 Common - FtsK M6_Spy0396 199 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 50913653 Common - LemA M6_Spy0307 131 COG1704 LemA, Uncharacterized conserved protein Function unknown 50914214 Common - NADH oxidase H2O-forming M6_Spy0868 246 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 50913943 Common - F0F1 ATP synthase subunit gamma M6_Spy0597 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 50914199 Common - guanosine 5'-monophosphate oxidoreductase M6_Spy0853 233 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 50914363 Pathogen - unknown phage protein M6_Spy1017 1 None None None 50914782 Common - N-acetylglucosamine-6-phosphate deacetylase M6_Spy1436 118 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 50915203 Common trmU tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase M6_Spy1857 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 50914943 Common - Deoxyribose-phosphate aldolase M6_Spy1597 138 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 50915191 Pathogen - hypothetical protein M6_Spy1845 1 None None None 50913615 Common - Hypothetical membrane spanning protein M6_Spy0269 8 COG4907 COG4907, Predicted membrane protein Function unknown 50915168 Pathogen - unknown phage protein M6_Spy1822 1 None None None 50914815 Common - Acetyltransferase M6_Spy1469 42 COG0456 RimI, Acetyltransferases General function prediction only 50915052 Common - hypothetical protein M6_Spy1706 1 None None None 50914822 Common - Hypothetical cytosolic protein M6_Spy1476 10 COG4687 COG4687, Uncharacterized protein conserved in bacteria Function unknown 50914073 Common - hypothetical protein M6_Spy0727 170 COG0344 COG0344, Predicted membrane protein Function unknown 50913666 Common - Aminodeoxychorismate lyase family M6_Spy0320 186 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 50914489 Common - DNA-cytosine methyltransferase M6_Spy1143 122 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 50914730 Common fmt methionyl-tRNA formyltransferase M6_Spy1384 217 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 50914854 Common - Hydrolase (HAD superfamily) M6_Spy1508 126 COG4696 COG4696, Uncharacterized protein conserved in bacteria Function unknown 161761321 Common rplK 50S ribosomal protein L11 M6_Spy0401 247 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 50913420 Common - phosphoribosylaminoimidazole synthetase M6_Spy0074 235 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 50914055 Common - GTPase EngB M6_Spy0709 194 COG0218 COG0218, Predicted GTPase General function prediction only 50914994 Common - Lactose phosphotransferase system repressor M6_Spy1648 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 50913932 Common - SagI M6_Spy0586 9 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 50914600 Common - Methenyltetrahydrofolate cyclohydrolase M6_Spy1254 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 50913829 Common - UDP-glucose 6-dehydrogenase M6_Spy0483 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 50913594 Pathogen - Hypothetical membrane spanning protein M6_Spy0248 1 COG5578 COG5578, Predicted integral membrane protein Function unknown 50914620 Common murD UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase M6_Spy1274 210 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 50913708 Common - Hypothetical membrane associated protein M6_Spy0362 2 None None None 50914697 Common - unknown phage protein M6_Spy1351 22 COG1340 COG1340, Uncharacterized archaeal coiled-coil protein Function unknown 50913570 Common - UTP--glucose-1-phosphate uridylyltransferase M6_Spy0224 233 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 50914402 Common - Hypothetical cytosolic protein M6_Spy1056 1 None None None 50913665 Common - Acetyltransferase (GNAT) family M6_Spy0319 11 COG0456 RimI, Acetyltransferases General function prediction only 50913624 Common - D-alanyl-D-alanine carboxypeptidase M6_Spy0278 139 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 50913701 Common - hypothetical protein M6_Spy0355 8 COG4471 COG4471, Uncharacterized protein conserved in bacteria Function unknown 50913820 Common - Transcriptional regulator M6_Spy0474 7 None None None 50913987 Common aroD 3-dehydroquinate dehydratase M6_Spy0641 51 COG0710 AroD, 3-dehydroquinate dehydratase Amino acid transport and metabolism 50914445 Common - Chloride channel protein M6_Spy1099 107 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 50913916 Common - Chloride channel protein M6_Spy0570 31 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 161761304 Common - acetyl-CoA carboxylase biotin carboxylase subunit M6_Spy1480 234 COG0439 AccC, Biotin carboxylase Lipid metabolism 50914473 Common - Holin M6_Spy1127 13 COG4824 COG4824, Phage-related holin (Lysis protein) General function prediction only 50913384 Pathogen - unknown phage protein M6_Spy0038 1 None None None 50913552 Common - CoA binding protein M6_Spy0206 119 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 50913458 Common rplO 50S ribosomal protein L15 M6_Spy0112 216 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 50913859 Common - Peptidase family U32 M6_Spy0513 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 50914464 Common - hypothetical protein M6_Spy1118 1 None None None 50914149 Common - PTS system, mannose/fructose family IID component M6_Spy0803 40 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 50915132 Common - Glyoxalase family protein M6_Spy1786 39 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 50914554 Pathogen - unknown phage protein M6_Spy1208 1 None None None 50913566 Common - Transcriptional regulator M6_Spy0220 2 None None None 50914264 Common - SIR2 family protein M6_Spy0918 16 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 50914833 Common acpP acyl carrier protein M6_Spy1487 187 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 50914758 Common mraY phospho-N-acetylmuramoyl-pentapeptide-transferase M6_Spy1412 228 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 50914326 Common - ABC transporter permease protein M6_Spy0980 2 None None None 50914795 Common - PTS system, galactose-specific IIB component M6_Spy1449 4 COG3414 SgaB, Phosphotransferase system, galactitol-specific IIB component Carbohydrate transport and metabolism 50913901 Common - acetoin reductase M6_Spy0555 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 50913637 Common nadD nicotinic acid mononucleotide adenyltransferase M6_Spy0291 187 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 50914845 Pathogen - hypothetical protein M6_Spy1499 1 None None None 50913939 Common - F0F1 ATP synthase subunit A M6_Spy0593 205 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 50914303 Common - Transcriptional regulator, TetR family M6_Spy0957 19 COG1309 AcrR, Transcriptional regulator Transcription 50914316 Common - Transcriptional regulator, DeoR family M6_Spy0970 8 COG3711 BglG, Transcriptional antiterminator Transcription 50914585 Pathogen - unknown phage protein M6_Spy1239 1 None None None 50915147 Common ruvA Holliday junction DNA helicase motor protein M6_Spy1801 210 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 50914242 Common - Citrate CoA-transferase M6_Spy0896 28 COG3051 CitF, Citrate lyase, alpha subunit Energy production and conversion 50914493 Common - S-adenosylmethionine synthetase M6_Spy1147 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 50913980 Common - Hypothetical membrane associated protein M6_Spy0634 1 None None None 50913861 Common - Hypothetical cytosolic protein M6_Spy0515 11 COG4443 COG4443, Uncharacterized protein conserved in bacteria Function unknown 50915006 Common - 23S rRNA Gm2251 methyltransferase M6_Spy1660 216 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 50914537 Common - dihydroorotate dehydrogenase 1A M6_Spy1191 226 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 50914436 Common - uridine kinase M6_Spy1090 81 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 50915084 Common - Transcriptional regulator M6_Spy1738 6 None None None 50913457 Common rpmD 50S ribosomal protein L30 M6_Spy0111 125 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 50914918 Common - Phosphatidylglycerophosphatase B M6_Spy1572 11 None None None 50914112 Common - Fibrinogen-binding protein M6_Spy0766 85 COG1293 COG1293, Predicted RNA-binding protein homologous to eukaryotic snRNP Transcription 50914398 Common - PTS system, mannitol (Cryptic)-specific IIA component M6_Spy1052 34 COG3711 BglG, Transcriptional antiterminator Transcription 50913684 Common - 23S rRNA methyltransferase M6_Spy0338 156 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 50914482 Common - unknown phage protein M6_Spy1136 4 COG5614 COG5614, Bacteriophage head-tail adaptor General function prediction only 50914723 Common - Peptidyl-prolyl cis-trans isomerase M6_Spy1377 218 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 50914330 Common - Sla M6_Spy0984 3 None None None 50913837 Pathogen - Hypothetical cytosolic protein M6_Spy0491 1 None None None 50915219 Common recF recombination protein F M6_Spy1873 166 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 50914871 Common acpS 4'-phosphopantetheinyl transferase M6_Spy1525 130 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 50913847 Common - Hypothetical membrane spanning protein M6_Spy0501 9 COG3689 COG3689, Predicted membrane protein Function unknown 50914441 Common - Phosphocarrier protein HPr M6_Spy1095 101 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 50914649 Common - bifunctional methionine sulfoxide reductase A/B protein M6_Spy1303 206 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 50914407 Common - nicotinate-nucleotide pyrophosphorylase M6_Spy1061 204 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 50913839 Pathogen - hypothetical protein M6_Spy0493 1 None None None 50913557 Common - Zinc finger protein M6_Spy0211 14 COG4357 COG4357, Uncharacterized conserved protein Function unknown 50914773 Common - Glycerol uptake facilitator protein M6_Spy1427 130 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 50913815 Common - VicR M6_Spy0469 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 50914221 Common - hypothetical protein M6_Spy0875 115 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 50913735 Common - 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase M6_Spy0389 86 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 50913414 Common - unknown phage protein M6_Spy0068 1 None None None 50913776 Pathogen - hypothetical protein M6_Spy0430 1 None None None 50914269 Common - Lipoate-protein ligase A M6_Spy0923 14 COG0095 LplA, Lipoate-protein ligase A Coenzyme metabolism 50914274 Common - Nucleoside transport system permease protein M6_Spy0928 131 COG1079 COG1079, Uncharacterized ABC-type transport system, permease component General function prediction only 50913798 Common - Glycosyltransferase M6_Spy0452 81 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 50914085 Pathogen - unknown phage protein M6_Spy0739 1 None None None 50914992 Common - galactose-6-phosphate isomerase subunit LacB M6_Spy1646 97 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 50914368 Common - unknown phage protein M6_Spy1022 3 None None None 50913991 Common - dihydrofolate synthase M6_Spy0645 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 50913791 Common - Permease M6_Spy0445 28 COG3817 COG3817, Predicted membrane protein Function unknown 50914711 Common - Terminase large subunit M6_Spy1365 8 None None None 50914235 Common - Mg2+/citrate complex secondary transporter M6_Spy0889 33 COG2851 CitM, H+/citrate symporter Energy production and conversion 50914022 Common - Thioredoxin reductase M6_Spy0676 245 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 50915095 Common - Pyruvate formate-lyase activating enzyme M6_Spy1749 68 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 50914183 Common - Hypothetical membrane spanning protein M6_Spy0837 96 COG0628 PerM, Predicted permease General function prediction only 50914673 Common - Sugar transport system permease protein M6_Spy1327 144 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 50914293 Common - Myo-inositol-1(or 4)-monophosphatase M6_Spy0947 180 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 50913584 Common rnpA ribonuclease P M6_Spy0238 74 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 50914177 Common - NAD-dependent malic enzyme M6_Spy0831 202 COG0281 SfcA, Malic enzyme Energy production and conversion 50915118 Common - Hypothetical cytosolic protein M6_Spy1772 5 COG3758 COG3758, Uncharacterized protein conserved in bacteria Function unknown 50913825 Common - S-adenosylmethionine synthetase M6_Spy0479 43 COG1812 MetK, Archaeal S-adenosylmethionine synthetase Amino acid transport and metabolism 50914950 Common - Glycoprotease protein family M6_Spy1604 190 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 50914125 Pathogen - hypothetical protein M6_Spy0780 1 None None None 50913521 Pathogen - V-type sodium ATP synthase subunit E M6_Spy0175 2 None None None 50915015 Common - transaldolase M6_Spy1669 94 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 50913879 Common - Hydrolase (HAD superfamily) M6_Spy0533 126 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 50913754 Common - Hypothetical cytosolic protein M6_Spy0408 12 COG4479 COG4479, Uncharacterized protein conserved in bacteria Function unknown 50914087 Pathogen - SpeA variant M6_Spy0741 2 None None None 50913792 Common - Permease M6_Spy0446 28 COG3819 COG3819, Predicted membrane protein Function unknown 50914279 Common - 16S rRNA m(2)G 1207 methyltransferase M6_Spy0933 107 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 50914352 Common - unknown phage protein M6_Spy1006 9 None None None 50914347 Pathogen - unknown phage protein M6_Spy1001 1 None None None 50915031 Common yajC preprotein translocase subunit YajC M6_Spy1685 8 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 50914651 Common - Cytochrome c-type biogenesis protein M6_Spy1305 189 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 161761309 Common obgE GTPase ObgE M6_Spy1057 249 COG0536 Obg, Predicted GTPase General function prediction only 50915064 Common - C5A peptidase precursor M6_Spy1718 67 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 50914747 Common - Multimodular transpeptidase-transglycosylase PBP 1A M6_Spy1401 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 50914800 Common - Copper-exporting ATPase M6_Spy1454 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 50915027 Common - prolyl-tRNA synthetase M6_Spy1681 238 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 50915049 Common - 4-amino-4-deoxychorismate lyase M6_Spy1703 221 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 50914384 Pathogen - Transposase M6_Spy1038 1 None None None 50913609 Common - 30S ribosomal protein S7 M6_Spy0263 248 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 50915214 Common - Transposase M6_Spy1868 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 50913976 Common - Hypothetical membrane spanning protein M6_Spy0630 7 COG4713 COG4713, Predicted membrane protein Function unknown 50914923 Common - Signal peptidase I M6_Spy1577 165 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 50914016 Common - Cell surface protein M6_Spy0670 16 None None None 50913436 Common - alcohol dehydrogenase M6_Spy0090 213 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 50914761 Common mraW S-adenosyl-methyltransferase MraW M6_Spy1415 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 50913447 Common rpmC 50S ribosomal protein L29 M6_Spy0101 11 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 50913600 Common ksgA dimethyladenosine transferase M6_Spy0254 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 50914895 Common - Phage infection protein M6_Spy1549 10 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 50914422 Common - Cytosolic protein containing multiple CBS domains M6_Spy1076 56 COG4109 COG4109, Predicted transcriptional regulator containing CBS domains Transcription 50914960 Common - Alkaline shock protein M6_Spy1614 35 COG1302 COG1302, Uncharacterized protein conserved in bacteria Function unknown 50914813 Common - hypothetical protein M6_Spy1467 1 None None None 50913501 Pathogen - Transcriptional regulator M6_Spy0155 1 None None None 50914339 Pathogen - Hyaluronoglucosaminidase M6_Spy0993 1 None None None 50914941 Common - Hypothetical cytosolic protein M6_Spy1595 2 None None None 50915221 Common - inositol-5-monophosphate dehydrogenase M6_Spy1875 240 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 50914768 Pathogen - hypothetical protein M6_Spy1422 1 None None None 50914004 Common - Uracil permease M6_Spy0658 123 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 50915113 Common - imidazolonepropionase M6_Spy1767 106 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 50914194 Common eutD phosphotransacetylase M6_Spy0848 166 COG0280 Pta, Phosphotransacetylase Energy production and conversion 50913783 Common - ATPase M6_Spy0437 78 COG0433 COG0433, Predicted ATPase General function prediction only 50914190 Common - Putative adenylate cyclase family M6_Spy0844 9 COG4116 COG4116, Uncharacterized protein conserved in bacteria Function unknown 50914205 Common prfA peptide chain release factor 1 M6_Spy0859 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 50914373 Pathogen - unknown phage protein M6_Spy1027 1 None None None 50914591 Common - Lipase/Acylhydrolase with GDSL-like motif M6_Spy1245 14 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 50914549 Common - Hyaluronoglucosaminidase M6_Spy1203 2 None None None 50914966 Common tig trigger factor M6_Spy1620 214 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 50914737 Common - Acetate CoA-transferase alpha subunit M6_Spy1391 98 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 50913771 Pathogen - hypothetical protein M6_Spy0425 1 None None None 50915171 Common - DNA mismatch repair protein M6_Spy1825 202 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 50915103 Common - hypothetical protein M6_Spy1757 5 COG4640 COG4640, Predicted membrane protein Function unknown 50913800 Common thrS threonyl-tRNA synthetase M6_Spy0454 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 50914999 Pathogen - DNA integration/recombination/invertion protein M6_Spy1653 1 None None None 50915193 Common - Hypothetical membrane associated protein M6_Spy1847 6 COG4709 COG4709, Predicted membrane protein Function unknown 50914292 Common - Putative 23S rRNA m(5)C methyltransferase M6_Spy0946 207 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 50913504 Pathogen - Reverse transcriptase M6_Spy0158 1 None None None 50914917 Common - Thioredoxin M6_Spy1571 232 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 50913394 Pathogen - unknown phage protein M6_Spy0048 1 None None None 50914095 Common - HflX M6_Spy0749 218 COG2262 HflX, GTPases General function prediction only 50913400 Pathogen - unknown phage protein M6_Spy0054 1 None None None 50913348 Common - DNA polymerase III subunit beta M6_Spy0002 214 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 50914161 Common - D-alanyl-D-alanine carboxypeptidase M6_Spy0815 152 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 50913622 Common - IscU M6_Spy0276 164 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 50913698 Common - Export protein for polysaccharides and teichoic acids M6_Spy0352 30 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 50914139 Common - Hypothetical membrane spanning protein M6_Spy0793 8 COG4478 COG4478, Predicted membrane protein Function unknown 50914928 Common - Penicillin-binding protein M6_Spy1582 68 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 50915187 Common - Transcriptional regulator M6_Spy1841 3 None None None 50914728 Common - Protein phosphatase 2C M6_Spy1382 131 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 50913518 Pathogen - hypothetical protein M6_Spy0172 1 None None None 50913642 Pathogen - hypothetical protein M6_Spy0296 1 None None None 50914044 Common - Two component system histidine kinase M6_Spy0698 210 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 50914755 Common - Amino acid ABC transporter permease protein M6_Spy1409 173 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 50913873 Common - Cell division protein ftsW M6_Spy0527 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 50913961 Common - Large-conductance mechanosensitive channel M6_Spy0615 30 COG1970 MscL, Large-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 50915003 Pathogen - Hypothetical membrane spanning protein M6_Spy1657 1 None None None 50914285 Pathogen - hypothetical protein M6_Spy0939 1 None None None 50913487 Common - Adenine-specific methyltransferase M6_Spy0141 10 COG0827 COG0827, Adenine-specific DNA methylase DNA replication, recombination, and repair 50914023 Common - Hypothetical membrane spanning protein M6_Spy0677 14 COG3641 PfoR, Predicted membrane protein, putative toxin regulator General function prediction only 50914168 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase M6_Spy0822 201 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 50913603 Common - Thiamin pyrophosphokinase M6_Spy0257 25 COG1564 THI80, Thiamine pyrophosphokinase Coenzyme metabolism 50914625 Common - Hypothetical cytosolic protein M6_Spy1279 9 COG4483 COG4483, Uncharacterized protein conserved in bacteria Function unknown