Leptospira interrogans serovar Lai str. 56601 chromosome II, complete sequence NC_004343 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 24217107 Pathogen - hypothetical protein LB046 1 None None None 24217268 Common - hypothetical protein LB207 4 None None None 24217348 Pathogen - hypothetical protein LB287 1 None None None 24217148 Common - hypothetical protein LB087 30 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 24217074 Common hemL glutamate-1-semialdehyde aminotransferase LB013 236 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 24217321 Pathogen - hypothetical protein LB260 1 None None None 24217339 Pathogen - hypothetical protein LB278 1 None None None 24217246 Pathogen - hypothetical protein LB185 1 None None None 24217170 Pathogen - hypothetical protein LB109 1 None None None 24217289 Common - Putative AraC-type Regulator LB228 20 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 24217282 Pathogen - hypothetical protein LB221 1 None None None 24217167 Common - S-adenosyl-L-homocysteine hydrolase LB106 177 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 24217378 Common - alanine racemase LB317 199 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 24217064 Pathogen - hypothetical protein LB004 1 None None None 24217332 Common - hypothetical protein LB271 49 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 24217090 Pathogen - hypothetical protein LB029 1 None None None 24217413 Pathogen - unknown protein confirmed by proteomics LB352 1 None None None 24217306 Common - probable sodium:solute symporter LB245 164 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 24217291 Common - putative transposase LB230 2 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 24217355 Common - elongation factor P LB294 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 24217330 Common - hypothetical protein LB269 26 COG3714 COG3714, Predicted membrane protein Function unknown 24217381 Pathogen - hypothetical protein LB320 1 None None None 24217235 Common htpX heat shock protein HtpX LB174 180 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 24217155 Common cyaA17 adenylate cyclase LB094 96 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 24217136 Pathogen - hypothetical protein LB076 1 None None None 24217221 Common cbiE precorrin-6Y methylase LB160 110 COG2241 CobL, Precorrin-6B methylase 1 Coenzyme metabolism 24217122 Common - hypothetical protein LB061 75 COG3211 PhoX, Predicted phosphatase General function prediction only 24217218 Common cbiH precorrin methylase LB157 175 COG1010 CobJ, Precorrin-3B methylase Coenzyme metabolism 24217387 Pathogen - hypothetical protein LB326 1 None None None 24217380 Pathogen - hypothetical protein LB319 1 None None None 24217404 Pathogen - cytochrome-c oxidase chain III LB343 1 None None None 24217161 Pathogen - hypothetical protein LB100 1 None None None 24217191 Common - transcriptional regulator, AraC family LB130 33 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 24217241 Pathogen - hypothetical protein LB180 1 None None None 24217062 Common - hypothetical protein LB001 3 None None None 24217146 Common - MutT/nudix family protein LB085 2 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 24217363 Pathogen - hypothetical protein LB302 1 None None None 24217131 Common - hypothetical protein LB070 31 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 24217129 Common - fatty acid desaturase LB068 51 COG1398 OLE1, Fatty-acid desaturase Lipid metabolism 24217284 Common - putative transposase LB223 145 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 24217277 Pathogen - hypothetical protein LB216 2 COG5422 ROM1, RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Signal transduction mechanisms 24217316 Common - 4-Hydroxybutyrate CoA-transferase LB255 101 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 24217114 Pathogen - hypothetical protein LB053 1 None None None 24217394 Common - two-component response regulator LB333 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 24217185 Common - HD-GYP domain (HD superfamily hydrolase) LB124 60 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 24217203 Common - hypothetical protein LB142 2 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 24217270 Pathogen - hypothetical protein LB209 1 None None None 24217280 Pathogen - hypothetical protein LB219 1 None None None 24217179 Common cyaA18 adenylate cyclase LB118 87 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 24217359 Common - L-lysine 2,3-aminomutase LB298 127 COG1509 KamA, Lysine 2,3-aminomutase Amino acid transport and metabolism 24217076 Common - two-component response regulator LB015 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 24217254 Pathogen - hypothetical protein LB193 1 None None None 24217310 Pathogen - hypothetical protein LB249 1 None None None 24217346 Common - hypothetical protein LB285 2 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 24217157 Common - hypothetical protein LB096 33 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 24217287 Common - Fimh-like protein LB226 10 None None None 24217354 Common - probable ARD family methionine salvage pathway enzyme LB293 37 COG1791 COG1791, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 24217383 Common - two-component hybrid sensor and regulator LB322 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 24217233 Common - hypothetical protein LB172 30 COG2252 COG2252, Permeases General function prediction only 24217308 Pathogen - hypothetical protein LB247 1 None None None 24217231 Common - similar to capsular polysaccharide biosynthesis protein LB170 192 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 24217272 Pathogen - hypothetical protein LB211 1 None None None 24217323 Common galF UDP-glucose pyrophosphorylase LB262 8 COG4284 COG4284, UDP-glucose pyrophosphorylase Carbohydrate transport and metabolism 24217138 Pathogen - hypothetical protein LB077 1 None None None 24217360 Pathogen - receptor tyrosine kinase LB299 1 None None None 24217334 Common mcm2 methylmalonyl-CoA mutase LB273 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 24217092 Pathogen - hypothetical protein LB032 1 None None None 24217190 Pathogen - hypothetical protein LB128 1 None None None 24217248 Common - hypothetical protein LB187 6 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 24217335 Common mcm3 methylmalonyl-CoA mutase LB274 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 24217112 Common - magnesium chelatase, putative LB051 174 COG0714 COG0714, MoxR-like ATPases General function prediction only 24217424 Pathogen - hypothetical protein LB363 1 None None None 24217193 Pathogen - hypothetical protein LB132 1 None None None 24217223 Common cbiD cobalt-precorrin-6A synthase LB162 86 COG1903 CbiD, Cobalamin biosynthesis protein CbiD Coenzyme metabolism 24217119 Common htpG2 heat shock protein 90 LB058 149 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 24217216 Common cobA cob(I)alamin adenosyltransferase LB155 142 COG2109 BtuR, ATP:corrinoid adenosyltransferase Coenzyme metabolism 24217183 Common - site-specific integrase/recombinase XerD related protein LB122 205 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 24217350 Pathogen - hypothetical protein LB289 1 None None None 24217201 Pathogen - hypothetical protein LB140 1 None None None 24217098 Pathogen - putative sucrose/H+ symporter LB037 1 None None None 24217089 Common - putative reductase LB028 13 COG0431 COG0431, Predicted flavoprotein General function prediction only 24217379 Pathogen - hypothetical protein LB318 1 None None None 24217389 Common ompA outer membrane protein OmpA LB328 137 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 24217086 Pathogen - hypothetical protein LB025 1 None None None 24217120 Pathogen - hypothetical protein LB059 1 None None None 24217320 Pathogen - hypothetical protein LB259 1 None None None 24217105 Pathogen - hypothetical protein LB044 1 None None None 24217369 Pathogen - hypothetical protein LB308 1 None None None 24217127 Pathogen - hypothetical protein LB066 1 None None None 24217361 Pathogen - hypothetical protein LB300 1 None None None 24217174 Common argB acetylglutamate kinase LB114 218 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 24217295 Pathogen - hypothetical protein LB234 1 None None None 24217227 Pathogen - hypothetical protein LB166 1 None None None 24217343 Common exbD3 transport protein ExbD LB282 147 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 24217166 Common - transcriptional regulator, ArsR family LB105 171 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 24217068 Common - hypothetical protein LB007 33 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 24217220 Common cobI precorrin-2 methyltransferase LB159 119 COG2243 CobF, Precorrin-2 methylase Coenzyme metabolism 24217178 Common - bacterioferritin comigratory protein LB117 224 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 24217151 Common - hypothetical protein LB090 5 None None None 24217242 Pathogen - hypothetical protein LB181 2 None None None 24217407 Common - putative transposase LB346 2 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 24217302 Common - two-component hybrid sensor and regulator LB241 224 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 24217209 Pathogen - hypothetical protein LB148 1 None None None 24217256 Pathogen - hypothetical protein LB195 1 None None None 24217274 Common exbD2 putative biopolymer transport protein LB213 8 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 24217111 Pathogen - hypothetical protein LB050 1 None None None 24217386 Common - transcriptional regulator, TetR family LB325 19 COG1309 AcrR, Transcriptional regulator Transcription 24217144 Common acp acyl carrier protein LB083 209 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 24217264 Common - hypothetical protein LB203 9 None None None 24217371 Common pyrF orotidine-5'-monophosphate decarboxylase LB310 67 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 24217262 Common lonA putative ATP-dependent protease LA LB201 133 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 24217200 Common - putative regulation protein contains HAMP domain LB139 113 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 24217301 Common - GGDEF family protein LB240 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 24217415 Pathogen - hypothetical protein LB354 1 None None None 24217340 Common - hypothetical protein LB279 14 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 24217070 Pathogen - hypothetical protein LB009 1 None None None 24217367 Pathogen - hypothetical protein LB306 1 None None None 24217066 Common - hypothetical protein LB005 35 COG2107 COG2107, Predicted periplasmic solute-binding protein General function prediction only 24217130 Pathogen - hypothetical protein LB069 1 None None None 24217095 Common - 3-oxoacyl-(acyl carrier protein) reductase LB034 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 24217128 Pathogen - hypothetical protein LB067 1 None None None 24217410 Pathogen - hypothetical protein LB349 1 None None None 24217402 Pathogen - hypothetical protein LB341 1 None None None 24217181 Common - hypothetical protein LB120 12 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 24217207 Common - hypothetical protein LB146 8 None None None 24217080 Pathogen - hypothetical protein LB019 1 None None None 24217398 Pathogen - hypothetical protein LB337 1 None None None 24217214 Common - hypothetical protein LB153 21 COG1865 COG1865, Uncharacterized conserved protein Function unknown 24217103 Pathogen - hypothetical protein LB042 1 COG3832 COG3832, Uncharacterized conserved protein Function unknown 24217195 Pathogen - hypothetical protein LB134 1 None None None 24217426 Common parA4 ParA protein LB365 225 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 24217421 Pathogen - hypothetical protein LB360 1 None None None 24217225 Common - unknown protein confirmed by proteomics LB164 7 None None None 24217325 Pathogen - hypothetical protein LB264 1 None None None 24217357 Pathogen - hypothetical protein LB296 1 None None None 24217327 Common - hypothetical protein LB266 81 COG0385 COG0385, Predicted Na+-dependent transporter General function prediction only 24217392 Pathogen - hypothetical protein LB330 1 None None None 24217222 Common cbiC cobalamin biosynthesis precorrin isomerase LB161 118 COG2082 CobH, Precorrin isomerase Coenzyme metabolism 24217417 Pathogen - hypothetical protein LB356 1 None None None 24217338 Pathogen - hypothetical protein LB277 1 None None None 24217153 Common - hypothetical protein LB092 2 None None None 24217118 Common batD BatD LB057 10 None None None 24217244 Common - transcriptional regulator (Fur family) LB183 92 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 24217172 Common - diphosphate--fructose-6-phosphate 1-phosphotransferase LB111 161 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 24217229 Common - hypothetical protein LB167 7 None None None 24217388 Common acn aconitate hydratase LB327 223 COG1048 AcnA, Aconitase A Energy production and conversion 24217399 Pathogen - hypothetical protein LB338 1 None None None 24217176 Pathogen - hypothetical protein LB115 1 None None None 24217142 Pathogen - hypothetical protein LB081 1 None None None 24217376 Pathogen - hypothetical protein LB315 1 None None None 24217072 Common hemC porphobilinogen deaminase LB011 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 24217283 Common - hypothetical protein LB222 90 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 24217428 Pathogen - hypothetical protein LB367 1 None None None 24217258 Pathogen - hypothetical protein LB197 1 None None None 24217266 Pathogen - hypothetical protein LB205 1 None None None 24217341 Pathogen - hypothetical protein LB280 1 None None None 24217251 Pathogen - hypothetical protein LB189 1 None None None 24217373 Common - hypothetical protein LB312 6 COG1586 SpeD, S-adenosylmethionine decarboxylase Amino acid transport and metabolism 24217149 Pathogen - hypothetical protein LB088 1 None None None 24217314 Pathogen - hypothetical protein LB253 1 None None None 24217205 Common - RNA polymerase ECF-type sigma factor LB144 3 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 24217313 Common - hypothetical protein LB252 151 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 24217101 Pathogen - hypothetical protein LB040 1 None None None 24217293 Pathogen - hypothetical protein LB232 1 None None None 24217085 Common - ferrochelatase LB024 30 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 24217082 Pathogen - hypothetical protein LB021 1 None None None 24217097 Common ndh NADH dehydrogenase LB036 218 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 24217365 Common - putative transposase LB304 2 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 24217318 Pathogen - hypothetical protein LB257 1 None None None 24217188 Pathogen - hypothetical protein LB127 1 None None None 24217285 Common - putative transposase LB224 2 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 24217140 Common hisE phosphoribosyl-ATP pyrophosphohydrolase LB079 192 COG0140 HisI, Phosphoribosyl-ATP pyrophosphohydrolase Amino acid transport and metabolism 24217126 Pathogen - hypothetical protein LB065 1 None None None 24217124 Common - hypothetical protein LB063 7 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 24217147 Common aroB 3-dehydroquinate synthase LB086 205 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 24217133 Pathogen - hypothetical protein LB072 1 None None None 24217197 Common - anti-sigma factor antagonist LB136 36 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 24217409 Common - hypothetical protein LB348 6 None None None 24217412 Pathogen - putative outermembrane protein LB351 1 None None None 24217116 Common vwa2 von Willebrand factor type A domain containing protein LB055 46 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 24217423 Pathogen - hypothetical protein LB362 1 None None None 24217219 Common cbiG cobalamin biosynthesis protein LB158 84 COG2073 CbiG, Cobalamin biosynthesis protein CbiG Coenzyme metabolism 24217212 Common cbiP cobyric acid synthase LB151 152 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 24217304 Common - hypothetical protein LB243 3 None None None 24217419 Pathogen - hypothetical protein LB358 1 None None None 24217210 Common pmgA phosphoglycerate mutase LB149 149 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 24217382 Pathogen - hypothetical protein LB321 1 None None None 24217199 Pathogen - hypothetical protein LB138 1 None None None 24217192 Common - putative transcriptional regulator, araC family protein LB131 78 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 24217162 Pathogen - hypothetical protein LB101 1 None None None 24217224 Common - Oxidoreductase FAD-binding family protein LB163 34 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 24217364 Common - putative transposase LB303 145 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 24217145 Common - ribonuclease III LB084 216 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 24217134 Common - lysine arginine ornithine transport system kinase LB073 99 COG1703 ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family Amino acid transport and metabolism 24217099 Pathogen - hypothetical protein LB038 1 None None None 24217240 Pathogen - hypothetical protein LB179 1 None None None 24217063 Common metF 5,10-methylenetetrahydrofolate reductase LB002 159 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 24217391 Pathogen - hypothetical protein LB331 1 None None None 24217204 Common - similar to putative lipoprotein qlp42 LB143 7 COG4254 COG4254, Uncharacterized protein conserved in bacteria Function unknown 24217106 Pathogen - hypothetical protein LB045 1 None None None 24217278 Pathogen - hypothetical protein LB217 2 None None None 24217087 Common parA3 ParA protein LB026 206 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 24217425 Common - transcriptional regulator (FIS family) LB364 4 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 24217115 Common vwa1 von Willebrand factor type A domain containing protein LB054 77 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 24217217 Common cbiF precorrin-3 methylase LB156 202 COG2875 CobM, Precorrin-4 methylase Coenzyme metabolism 24217317 Pathogen - hypothetical protein LB256 1 None None None 24217186 Common cheD2 chemotaxis protein LB125 85 COG1871 CheD, Chemotaxis protein; stimulates methylation of MCP proteins Cell motility and secretion / Signal transduction mechanisms 24217259 Common - hypothetical protein LB198 11 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 24217375 Pathogen - hypothetical protein LB313 1 None None None 24217347 Common gltB2 glutamate synthase LB286 202 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 24217253 Pathogen - hypothetical protein LB192 1 None None None 24217075 Common - two-component hybrid sensor and regulator LB014 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 24217108 Common - hypothetical protein LB047 17 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 24217329 Common - hypothetical protein LB268 7 COG1633 COG1633, Uncharacterized conserved protein Function unknown 24217276 Common ubiE ubiquinone/menaquinone biosynthesis methlytransferase LB215 215 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 24217267 Pathogen - hypothetical protein LB206 1 None None None 24217238 Common - putative serine protease LB177 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 24217281 Pathogen - hypothetical protein LB220 1 None None None 24217180 Pathogen - hypothetical protein LB119 2 None None None 24217164 Common - hypothetical protein LB103 17 COG0824 FcbC, Predicted thioesterase General function prediction only 24217333 Common - hypothetical protein LB272 96 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 24217322 Common - hypothetical protein LB261 5 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 24217189 Pathogen - hypothetical protein LB129 1 None None None 24217168 Common - ferredoxin LB107 136 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 24217232 Pathogen - hypothetical protein LB171 1 None None None 24217091 Common - probable intercellular adhesion protein C LB030 16 COG3274 COG3274, Uncharacterized protein conserved in bacteria Function unknown 24217247 Common - heme oxygenase LB186 24 COG5398 COG5398, Heme oxygenase Inorganic ion transport and metabolism 24217156 Pathogen - hypothetical protein LB095 1 None None None 24217137 Pathogen - hypothetical protein LB075 1 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 24217307 Pathogen - hypothetical protein LB246 1 None None None 24217370 Common - similar to Fimh-like protein LB309 11 None None None 24217356 Common - putative transposase LB295 112 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 24217249 Pathogen - hypothetical protein LB188 1 None None None 24217194 Common - probable protein containing EAL domain LB133 163 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 24217113 Common - hypothetical protein LB052 97 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 24217405 Pathogen - hypothetical protein LB344 1 None None None 24217215 Common cbiA cobyrinic acid-diamide synthase LB154 136 COG1797 CobB, Cobyrinic acid a,c-diamide synthase Coenzyme metabolism 24217150 Common - Uncharacterized FAD-dependent dehydrogenase LB089 81 COG2509 COG2509, Uncharacterized FAD-dependent dehydrogenases General function prediction only 24217202 Pathogen - similar to putative lipoprotein qlp42 LB141 2 COG4254 COG4254, Uncharacterized protein conserved in bacteria Function unknown 24217427 Common parB4 ParB family protein LB366 184 COG1475 Spo0J, Predicted transcriptional regulators Transcription 24217393 Pathogen - hypothetical protein LB332 1 None None None 24217420 Common - alginate O-acetylation protein LB359 85 COG1696 DltB, Predicted membrane protein involved in D-alanine export Cell envelope biogenesis, outer membrane 24217088 Common parB3 ParB protein LB027 185 COG1475 Spo0J, Predicted transcriptional regulators Transcription 24217104 Pathogen - unknown protein confirmed by proteomics LB043 1 None None None 24217353 Common - probable sugar aldolase LB292 47 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 24217400 Pathogen - hypothetical protein LB339 1 None None None 24217226 Common cbiX putative cbiX protein LB165 100 COG2138 COG2138, Uncharacterized conserved protein Function unknown 24217269 Common - alginate o-acetyltransferase LB208 85 COG1696 DltB, Predicted membrane protein involved in D-alanine export Cell envelope biogenesis, outer membrane 24217297 Pathogen - hypothetical protein LB236 1 None None None 24217079 Pathogen - hypothetical protein LB018 1 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 24217081 Common hemG protoporphyrinogen oxidase LB020 28 COG1232 HemY, Protoporphyrinogen oxidase Coenzyme metabolism 24217311 Pathogen - hypothetical protein LB250 1 None None None 24217184 Common aroK shikimic acid kinase I LB123 133 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 24217132 Pathogen - hypothetical protein LB071 1 None None None 24217362 Pathogen - hypothetical protein LB301 1 None None None 24217345 Pathogen - hypothetical protein LB284 1 None None None 24217236 Pathogen - hypothetical protein LB175 1 None None None 24217077 Common hemE uroporphyrinogen decarboxylase LB016 174 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 24217110 Pathogen - hypothetical protein LB049 1 None None None 24217255 Pathogen - unknown protein confirmed by proteomics LB194 1 None None None 24217377 Pathogen - unknown protein confirmed by proteomics LB316 1 None None None 24217351 Common - two-component hybrid sensor and regulator LB290 216 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 24217213 Common cobP cobinamide kinase LB152 129 COG2087 CobU, Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase Coenzyme metabolism 24217260 Pathogen - putative outermembrane protein LB199 1 None None None 24217299 Common - putative CACHE family protein LB238 16 None None None 24217139 Common - TPR-repeat-containing protein LB078 91 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 24217384 Common - lytic transglycosylase LB323 173 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 24217414 Common pyk2 pyruvate kinase LB353 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 24217271 Common - alginate o-acetyltransferase LB210 85 COG1696 DltB, Predicted membrane protein involved in D-alanine export Cell envelope biogenesis, outer membrane 24217309 Common - hypothetical protein LB248 3 None None None 24217158 Common - Predicted xylanase/chitin deacetilase LB098 108 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 24217093 Common - cyclic nucleotide dependent protein kinase LB031 98 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 24217230 Pathogen - hypothetical protein LB169 1 None None None 24217169 Common metH B12-dependent methionine synthase LB108 178 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 24217396 Common phhB pterin-4-alpha-carbinolamine dehydratase LB335 75 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 24217065 Pathogen - hypothetical protein LB003 1 None None None 24217336 Common argK arginine/ornithine transport system ATPase LB275 100 COG1703 ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family Amino acid transport and metabolism 24217344 Common - TonB protein LB283 2 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 24217300 Pathogen - hypothetical protein LB239 1 None None None 24217324 Pathogen - hypothetical protein LB263 1 None None None 24217143 Common - 3-ketoacyl-acyl carrier protein reductase LB082 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 24217292 Common - putative transposase LB231 145 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 24217109 Common - putative transposase LB048 111 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 24217352 Common - 3-oxoacyl-[acyl-carrier protein] reductase LB291 229 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 24217067 Pathogen - hypothetical protein LB006 1 None None None 24217187 Common traB pheromone shutdown protein LB126 38 COG1916 COG1916, Uncharacterized homolog of PrgY (pheromone shutdown protein) Function unknown 24217125 Pathogen - hypothetical protein LB064 1 None None None 24217422 Pathogen - hypothetical protein LB361 1 None None None 24217100 Pathogen - hypothetical protein LB039 1 None None None 24217395 Pathogen - hypothetical protein LB334 1 None None None 24217094 Pathogen - unknown protein confirmed by proteomics LB033 1 None None None 24217083 Common - transposase LB022 110 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 24217102 Common - 3-oxoacyl-(acyl carrier protein) reductase LB041 227 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 24217312 Common - hypothetical protein LB251 5 COG2730 BglC, Endoglucanase Carbohydrate transport and metabolism 24217401 Pathogen - hypothetical protein LB340 1 None None None 24217239 Common - putative serine protease LB178 16 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 24217208 Common - conserved hyperthetical protein LB147 5 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 24217182 Common - 3-oxoacyl-(acyl carrier protein) reductase LB121 236 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 24217406 Common - putative transposase LB345 112 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 24217123 Common - anti-anti-sigma factor LB062 4 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 24217228 Pathogen - hypothetical protein LB168 1 None None None 24217196 Pathogen - hypothetical protein LB135 1 None None None 24217326 Pathogen - hypothetical protein LB265 1 COG2267 PldB, Lysophospholipase Lipid metabolism 24217159 Pathogen - hypothetical protein LB097 1 None None None 24217337 Pathogen - hypothetical protein LB276 1 None None None 24217177 Common - hypothetical protein LB116 56 COG3975 COG3975, Predicted protease with the C-terminal PDZ domain General function prediction only 24217288 Pathogen - hypothetical protein LB227 1 None None None 24217152 Pathogen - hypothetical protein LB091 1 None None None 24217160 Pathogen - hypothetical protein LB099 1 None None None 24217173 Common - putative regulatory protein contains GAF domain LB112 121 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 24217243 Pathogen - hypothetical protein LB182 1 None None None 24217349 Common - hypothetical protein LB288 17 COG0824 FcbC, Predicted thioesterase General function prediction only 24217416 Common asd aspartate-semialdehyde dehydrogenase LB355 198 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 24217273 Common - hypothetical protein LB212 25 COG1694 MazG, Predicted pyrophosphatase General function prediction only 24217141 Pathogen - hypothetical protein LB080 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 24217198 Pathogen - hypothetical protein LB137 1 None None None 24217303 Common - hypothetical protein LB242 5 COG4254 COG4254, Uncharacterized protein conserved in bacteria Function unknown 24217257 Common - putative LRR repeat family protein LB196 13 None None None 24217342 Common exbB transport protein ExbB LB281 138 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 24217261 Pathogen - hypothetical protein LB200 1 None None None 24217234 Pathogen - hypothetical protein LB173 1 None None None 24217298 Common - GGDEF family protein LB237 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 24217263 Common - queuosine biosynthesis protein LB202 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 24217078 Common hemF coproporphyrinogen III oxidase LB017 205 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 24217071 Common hemA glutamyl-tRNA reductase LB010 6 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 24217368 Common - hypothetical protein LB307 70 COG1238 COG1238, Predicted membrane protein Function unknown 24217372 Common speE2 spermidine synthase LB311 121 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 24217084 Common - ferrochelatase LB023 40 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 24217275 Common - MotA/ExbB proton channel family protein LB214 78 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 24217390 Common lysS2 lysyl-tRNA synthetase LB329 209 COG2269 COG2269, Truncated, possibly inactive, lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 24217397 Pathogen - hypothetical protein LB336 1 None None None 24217319 Common - Cysteine protease LB258 32 COG4870 COG4870, Cysteine protease Posttranslational modification, protein turnover, chaperones 24217294 Pathogen - hypothetical protein LB233 1 None None None 24217403 Pathogen - hypothetical protein LB342 1 None None None 24217315 Common - putative sugar transport protein LB254 171 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 24217366 Common - hypothetical protein LB305 6 COG3216 COG3216, Uncharacterized protein conserved in bacteria Function unknown 24217237 Common - adenine phosphoribosyltransferase LB176 193 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 24217121 Pathogen - hypothetical protein LB060 1 None None None 24217286 Common - hypothetical protein LB225 20 None None None 24217096 Common amsI low molecular weight phosphotyrosine protein phosphatase LB035 130 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 24217411 Pathogen - hypothetical protein LB350 1 None None None 24217175 Common - 3-oxoacyl-(acyl carrier protein) reductase LB113 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 24217211 Common cbiB cobalamin biosynthesis protein B LB150 152 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 24217163 Common - phospholysine phosphohistidine inorganic pyrophosphate phosphatase LB102 103 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 24217408 Pathogen - hypothetical protein LB347 1 None None None 24217418 Pathogen - hypothetical protein LB357 1 None None None 24217358 Common pstS phosphate-binding protein PstS LB297 135 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 24217171 Pathogen - putative outermembrane protein LB110 1 None None None 24217154 Common fadD probable long-chain-fatty-acid--CoA ligase LB093 213 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 24217305 Common - hypothetical protein LB244 4 None None None 24217117 Common - TPR-repeat-containing protein LB056 38 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 24217069 Common - hypothetical protein LB008 71 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 24217331 Pathogen - hypothetical protein LB270 1 None None None 24217073 Common hemB delta-aminolevulinic acid dehydratase LB012 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 24217385 Pathogen - hypothetical protein LB324 1 None None None 24217290 Pathogen - hypothetical protein LB229 1 None None None 24217165 Common - putative TetR-family transcriptional regulator LB104 20 COG1309 AcrR, Transcriptional regulator Transcription 24217245 Pathogen - hypothetical protein LB184 1 None None None 24217296 Common - probable protein contain EAL family signaling protein LB235 169 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 24217328 Common - aminotransferase LB267 233 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 24217279 Common - hypothetical protein LB218 6 COG2339 COG2339, Predicted membrane protein Function unknown 24217374 Pathogen - hypothetical protein LB314 1 None None None 24217250 Pathogen - hypothetical protein LB190 1 None None None 24217252 Common - putative TonB-dependent outer membrane receptor protein LB191 125 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 24217206 Pathogen - hypothetical protein LB145 1 None None None 24217265 Common mtfA mannosyltransferase A LB204 123 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 24217135 Common mcm2 methylmalonyl-CoA mutase LB074 123 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism