Streptococcus pyogenes MGAS8232, complete genome NC_003485 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 19746395 Pathogen - hypothetical protein spyM18_1453 1 None None None 19745960 Common pnp purine nucleoside phosphorylase spyM18_0953 133 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 19745410 Common - hypothetical protein spyM18_0265 8 COG4907 COG4907, Predicted membrane protein Function unknown 19745366 Common gpsA NAD(P)H-dependent glycerol-3-phosphate dehydrogenase spyM18_0212 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 19745701 Common - hypothetical protein spyM18_0657 3 None None None 19745322 Common - V-type ATP synthase subunit F spyM18_0148 5 COG1436 NtpG, Archaeal/vacuolar-type H+-ATPase subunit F Energy production and conversion 19745341 Common - hypothetical protein spyM18_0175 41 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 19746759 Common uvrA excinuclease ABC subunit A spyM18_1890 240 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 19746424 Common - hypothetical protein spyM18_1487 3 None None None 19746713 Common dnaJ heat-shock (chaperone) protein spyM18_1830 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 19745710 Common - hypothetical protein spyM18_0667 13 COG3859 COG3859, Predicted membrane protein Function unknown 19746044 Common - putative D,D-carboxypeptidase, penicillin-binding protein spyM18_1051 151 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 19745914 Common - hypothetical protein spyM18_0898 184 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 19745826 Common - hypothetical protein spyM18_0797 6 COG5506 COG5506, Uncharacterized conserved protein Function unknown 19745220 Common purL putative phosphoribosylformylglycinamidine synthase II spyM18_0026 233 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 19746581 Common - putative penicillin binding protein spyM18_1674 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 19746502 Common - hypothetical protein spyM18_1572 110 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 19745307 Common prtF2l protein F2-like protein spyM18_0132 10 COG4932 COG4932, Predicted outer membrane protein Cell envelope biogenesis, outer membrane 19745496 Common - hypothetical protein spyM18_0382 40 COG5283 COG5283, Phage-related tail protein Function unknown 19745295 Common pheT1 hypothetical protein spyM18_0119 200 COG0073 ARC1, EMAP domain General function prediction only 19745515 Common - putative rRNA methylase spyM18_0406 207 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 19746746 Common secA preprotein translocase subunit SecA spyM18_1873 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 19746350 Common - hypothetical protein spyM18_1391 2 None None None 19746276 Pathogen - hypothetical protein spyM18_1305 1 None None None 19746692 Common - hypothetical protein spyM18_1806 18 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 19745728 Common - putative transcriptional regulator spyM18_0692 125 COG1609 PurR, Transcriptional regulators Transcription 19745790 Common - putative ClpP protease spyM18_0755 55 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 19746895 Common - anthranilate synthase component II spyM18_2057 239 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 19746002 Common - hypothetical protein spyM18_0999 54 COG2984 COG2984, ABC-type uncharacterized transport system, periplasmic component General function prediction only 19745213 Common - putative amino acid permease spyM18_0015 190 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 19746902 Common dppA surface lipoprotein spyM18_2066 202 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 19746744 Common alr alanine racemase spyM18_1871 200 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 19746496 Common argR putative arginine repressor spyM18_1566 57 COG1438 ArgR, Arginine repressor Transcription 19745909 Common pyrB aspartate carbamoyltransferase catalytic subunit spyM18_0892 237 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 19746562 Common - 3-hydroxybutyrate dehydrogenase spyM18_1649 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 19746911 Common emm18 M18 protein precursor spyM18_2076 31 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 19746330 Pathogen grab GRAB precursor spyM18_1369 1 None None None 19746870 Common - putative transcriptional regulator spyM18_2027 97 COG1846 MarR, Transcriptional regulators Transcription 19745601 Pathogen - hypothetical protein spyM18_0520 1 None None None 19746210 Common - hypothetical protein spyM18_1235 3 None None None 19745391 Common - hypothetical protein spyM18_0242 85 COG1737 RpiR, Transcriptional regulators Transcription 19746061 Common - putative zinc-containing alcohol dehydrogenase spyM18_1073 206 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 19745923 Common trmD tRNA (guanine-N(1)-)-methyltransferase spyM18_0908 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 19746798 Common rpsN 30S ribosomal protein S14 spyM18_1936 205 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 19745673 Pathogen - hypothetical protein spyM18_0618 1 None None None 19746480 Common - putative peroxide resistance protein spyM18_1548 112 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 19745958 Common deoB phosphopentomutase spyM18_0951 70 COG1015 DeoB, Phosphopentomutase Carbohydrate transport and metabolism 19747010 Common - hypothetical protein spyM18_2211 6 COG4709 COG4709, Predicted membrane protein Function unknown 19746803 Common - hypothetical protein spyM18_1941 161 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 19746812 Common rpmB 50S ribosomal protein L28 spyM18_1953 81 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 19745323 Common - V-type ATP synthase subunit A spyM18_0150 247 COG1155 NtpA, Archaeal/vacuolar-type H+-ATPase subunit A Energy production and conversion 19746326 Common - hypothetical protein spyM18_1365 35 COG1295 Rbn, Predicted membrane protein Function unknown 19745902 Common rpmA 50S ribosomal protein L27 spyM18_0885 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 19747028 Common - phosphatidylglycerophosphate synthase spyM18_2231 204 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 19746419 Common - putative structural phage protein spyM18_1481 2 None None None 19746738 Common - putative ABC transporter (ATP-binding protein) spyM18_1863 249 COG4988 CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 19746093 Common - hypothetical protein spyM18_1106 6 None None None 19746644 Pathogen - hypothetical protein spyM18_1753 1 None None None 19745225 Common - putative choline binding protein spyM18_0031 8 COG3942 COG3942, Surface antigen General function prediction only 19745689 Common - putative transcription antiterminator spyM18_0640 29 COG3711 BglG, Transcriptional antiterminator Transcription 19746195 Common pcrA putative ATP-dependent DNA helicase spyM18_1217 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 19746072 Common prsA ribose-phosphate pyrophosphokinase spyM18_1084 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 19746139 Pathogen - hypothetical protein spyM18_1158 1 None None None 19746316 Common - hypothetical protein spyM18_1352 26 COG5496 COG5496, Predicted thioesterase General function prediction only 19745619 Common proP putative multi-drug resistance efflux pump spyM18_0559 100 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 19745669 Common - hypothetical protein spyM18_0613 3 None None None 19745379 Common rnpA ribonuclease P spyM18_0228 74 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 19746389 Common - MF3 spyM18_1446 6 None None None 19746166 Common - putative histidine kinase protein spyM18_1186 218 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 19746076 Common - hypothetical protein spyM18_1088 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 19747036 Common recF recombination protein F spyM18_2242 166 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 19745678 Pathogen - hypothetical protein spyM18_0626 3 COG0439 AccC, Biotin carboxylase Lipid metabolism 19746546 Common - hypothetical protein spyM18_1629 218 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 19745386 Common - putative sugar transport protein (permease) spyM18_0237 158 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 19745654 Common smc putative chromosome segregation SMC spyM18_0598 219 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 19746200 Common - putative amino acid ABC transporter (ATP-binding protein) spyM18_1224 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 19746864 Pathogen - hypothetical protein spyM18_2020 1 None None None 19746753 Common - putative sucrose operon repressor spyM18_1883 127 COG1609 PurR, Transcriptional regulators Transcription 19745553 Common - DNA replication intiation control protein YabA spyM18_0455 15 COG4467 COG4467, Uncharacterized protein conserved in bacteria Function unknown 19747006 Common - hypothetical protein spyM18_2203 2 None None None 19746418 Common - hypothetical protein spyM18_1480 2 None None None 19746382 Common - hypothetical protein spyM18_1435 4 None None None 19745926 Common apbA 2-dehydropantoate 2-reductase spyM18_0911 129 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 19745292 Common tra putative transposase spyM18_0116 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 19746023 Common - hypothetical protein spyM18_1023 21 COG3884 FatA, Acyl-ACP thioesterase Lipid metabolism 19745302 Common lepA LepA spyM18_0127 32 COG4959 TraF, Type IV secretory pathway, protease TraF Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 19746997 Common aspS aspartyl-tRNA synthetase spyM18_2188 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 19745367 Common - hypothetical protein spyM18_0213 11 COG1846 MarR, Transcriptional regulators Transcription 19745467 Common - putative phage DNA replication protein spyM18_0350 10 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 19745889 Common - hypothetical protein spyM18_0870 129 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 19746041 Common tra putative transposase spyM18_1046 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 19745711 Common - putative endolysin, phage associated spyM18_0668 8 COG3757 Acm, Lyzozyme M1 (1,4-beta-N-acetylmuramidase) Cell envelope biogenesis, outer membrane 19745598 Common - putative diacylglycerol kinase spyM18_0516 100 COG0818 DgkA, Diacylglycerol kinase Cell envelope biogenesis, outer membrane 19745758 Common - putative antirepressor spyM18_0723 44 COG3645 COG3645, Uncharacterized phage-encoded protein Function unknown 19745856 Pathogen - hypothetical protein spyM18_0831 1 None None None 19746408 Pathogen - hypothetical protein spyM18_1467 1 None None None 19746017 Common - putative UDP-N-acetylmuramyl tripeptide synthetase spyM18_1017 60 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 19745867 Common - hypothetical protein spyM18_0842 143 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 19746777 Common dinP DNA polymerase IV spyM18_1910 185 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 19746256 Common - hypothetical protein spyM18_1285 2 None None None 19746977 Common nrdD anaerobic ribonucleoside triphosphate reductase spyM18_2168 112 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 19746774 Common lepB putative signal peptidase I spyM18_1907 160 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 19745846 Common atpG F0F1 ATP synthase subunit gamma spyM18_0817 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 19746729 Common - hypothetical protein spyM18_1852 126 COG4696 COG4696, Uncharacterized protein conserved in bacteria Function unknown 19745634 Common - putative glucosyl transferase spyM18_0575 208 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 19746295 Common uvrB excinuclease ABC subunit B spyM18_1326 226 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 19745943 Common - putative two-component sensory transduction histidine kinase spyM18_0936 210 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 19746883 Common - D-tyrosyl-tRNA deacylase spyM18_2044 139 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 19746828 Pathogen - hypothetical protein spyM18_1977 1 None None None 19746241 Common - putative antirepressor spyM18_1270 42 COG3645 COG3645, Uncharacterized phage-encoded protein Function unknown 19745488 Common - hypothetical protein spyM18_0372 5 None None None 19746922 Pathogen - hypothetical protein spyM18_2095 1 None None None 19745884 Common cmk cytidylate kinase spyM18_0865 205 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 19746449 Common recN putative DNA repair and genetic recombination protein spyM18_1513 207 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 19745509 Common murC UDP-N-acetylmuramate--L-alanine ligase spyM18_0398 211 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 19746931 Common - fructose-6-phosphate aldolase spyM18_2109 108 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 19745610 Pathogen - hypothetical protein spyM18_0547 1 None None None 19746173 Common pstC putative phosphate ABC transporter spyM18_1193 227 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 19745772 Common - hypothetical protein spyM18_0737 5 None None None 19745372 Common radA DNA repair protein RadA spyM18_0220 212 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 19745502 Pathogen - hypothetical protein spyM18_0388 1 None None None 19746524 Common - putative sugar-binding transport protein spyM18_1599 144 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 19746151 Common - hypothetical protein spyM18_1170 105 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 19746664 Common - putative minor capsid protein spyM18_1778 2 None None None 19745764 Pathogen - hypothetical protein spyM18_0729 1 None None None 19746263 Common - hypothetical protein spyM18_1292 4 None None None 19746639 Common - streptodornase spyM18_1746 5 None None None 19745573 Common glpT putative glycerol-3-phosphate transporter spyM18_0485 56 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 19746847 Common - putative transcription regulator spyM18_2001 50 COG1476 COG1476, Predicted transcriptional regulators Transcription 19746672 Pathogen - hypothetical protein spyM18_1786 1 None None None 19746184 Common - hypothetical protein spyM18_1205 37 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 19746852 Pathogen - hypothetical protein spyM18_2006 1 None None None 19745434 Common - hypothetical protein spyM18_0309 26 COG1323 COG1323, Predicted nucleotidyltransferase General function prediction only 19745571 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase spyM18_0483 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 19745518 Common - hypothetical protein spyM18_0409 1 COG3763 COG3763, Uncharacterized protein conserved in bacteria Function unknown 19746371 Common - putative competence protein spyM18_1417 104 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 19745729 Common - hypothetical protein spyM18_0693 15 None None None 19745286 Common - hypothetical protein spyM18_0109 1 None None None 19745700 Common - hypothetical protein spyM18_0656 11 COG4768 COG4768, Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain General function prediction only 19746646 Pathogen - hypothetical protein spyM18_1755 1 None None None 19746318 Common - hypothetical protein spyM18_1356 7 COG4868 COG4868, Uncharacterized protein conserved in bacteria Function unknown 19746948 Common tra putative transposase spyM18_2133 55 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 19745370 Common - hypothetical protein spyM18_0218 67 COG1636 COG1636, Uncharacterized protein conserved in bacteria Function unknown 19746105 Common hylIII putative hemolysin III spyM18_1119 119 COG1272 COG1272, Predicted membrane protein, hemolysin III homolog General function prediction only 19745336 Pathogen - hypothetical protein spyM18_0168 1 None None None 19745541 Common fhuD ferrichrome ABC transporter (ferrichrome-binding protein) spyM18_0438 14 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 19746205 Common pyk pyruvate kinase spyM18_1230 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 19745612 Pathogen - hypothetical protein spyM18_0549 1 None None None 19746709 Common acpP acyl carrier protein spyM18_1825 187 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 19746651 Common - hypothetical protein spyM18_1763 23 COG1340 COG1340, Uncharacterized archaeal coiled-coil protein Function unknown 19745675 Pathogen - hypothetical protein spyM18_0621 1 None None None 19746222 Pathogen - hypothetical protein spyM18_1249 1 None None None 19746658 Pathogen - hypothetical protein spyM18_1771 1 None None None 19745562 Common metG methionyl-tRNA synthetase spyM18_0468 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 19746771 Common - hypothetical protein spyM18_1904 9 COG1286 CvpA, Uncharacterized membrane protein, required for colicin V production General function prediction only 19745428 Common - hypothetical protein spyM18_0302 34 COG1161 COG1161, Predicted GTPases General function prediction only 19745995 Common cpsFO glucose-1-phosphate thymidyl transferase spyM18_0990 234 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 19746283 Common malQ putative 4-alpha-glucanotransferase spyM18_1312 117 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 19745587 Common rplA 50S ribosomal protein L1 spyM18_0504 238 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 19746082 Common - guanosine 5'-monophosphate oxidoreductase spyM18_1095 233 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 19745261 Common secY preprotein translocase subunit SecY spyM18_0073 220 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 19747015 Common - hypothetical protein spyM18_2216 2 COG4466 Veg, Uncharacterized protein conserved in bacteria Function unknown 19746995 Common - hypothetical protein spyM18_2186 55 COG1284 COG1284, Uncharacterized conserved protein Function unknown 19746954 Common hutI imidazolonepropionase spyM18_2139 107 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 19745690 Common - beta-glucoside permease IIABC component spyM18_0641 60 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 19745896 Common nifS putative iron-sulfur cofactor synthesis protein spyM18_0878 238 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 19746137 Common - putative antimicrobial resistance factor spyM18_1156 19 COG2348 COG2348, Uncharacterized protein involved in methicillin resistance Defense mechanisms 19746723 Common gatA aspartyl/glutamyl-tRNA amidotransferase subunit A spyM18_1840 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 19746140 Common - hypothetical protein spyM18_1159 7 COG4720 COG4720, Predicted membrane protein Function unknown 19745592 Common - hypothetical protein spyM18_0510 12 COG4479 COG4479, Uncharacterized protein conserved in bacteria Function unknown 19746146 Common fhs putative formate-tetrahydrofolate ligase spyM18_1165 89 COG2759 MIS1, Formyltetrahydrofolate synthetase Nucleotide transport and metabolism 19745823 Common - hypothetical protein spyM18_0794 13 COG0546 Gph, Predicted phosphatases General function prediction only 19745835 Common sagH SagH spyM18_0806 36 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 19745259 Common rpmD 50S ribosomal protein L30 spyM18_0071 125 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 19745797 Common - hypothetical protein spyM18_0762 6 None None None 19745486 Common - hypothetical protein spyM18_0370 5 None None None 19745713 Common - hypothetical protein spyM18_0670 4 None None None 19746011 Common acoB putative acetoin dehydrogenase (TPP-dependent) beta chain spyM18_1010 218 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 19746534 Common recX recombination regulator RecX spyM18_1616 24 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 19746784 Common - putative antibiotic resistance protein spyM18_1920 139 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 19745350 Common - hypothetical protein spyM18_0185 118 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 19746436 Pathogen - hypothetical protein spyM18_1499 1 None None None 19745287 Common - hypothetical protein spyM18_0110 10 COG0827 COG0827, Adenine-specific DNA methylase DNA replication, recombination, and repair 19746505 Common - oxidoreductase spyM18_1577 137 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 19746257 Pathogen - hypothetical protein spyM18_1286 1 None None None 19746132 Common ffh putative signal recognition particle -inhibited division protein spyM18_1151 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 19746555 Common - DNA-directed RNA polymerase subunit omega spyM18_1640 12 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 19746783 Common tra putative transposase spyM18_1918 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 19746769 Common - hypothetical protein spyM18_1902 11 None None None 19746512 Common aroA 3-deoxy-7-phosphoheptulonate synthase spyM18_1585 186 COG2876 AroA, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 19746487 Common - hypothetical protein spyM18_1555 211 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 19745659 Pathogen - hypothetical protein spyM18_0603 1 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 19745313 Common - butyrate-acetoacetate CoA-transferase, beta subunit spyM18_0138 107 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 19745683 Common tnpA transposase TnpA fragment spyM18_0634 143 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 19745404 Common rpsG 30S ribosomal protein S7 spyM18_0259 248 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 19745238 Common adhP alcohol dehydrogenase spyM18_0045 214 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 19746335 Pathogen - hypothetical protein spyM18_1375 1 None None None 19746346 Common nrdH putative glutaredoxin spyM18_1386 37 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 19746706 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase spyM18_1821 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 19745277 Common rpoB DNA-directed RNA polymerase subunit beta spyM18_0099 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 19747035 Common - hypothetical protein spyM18_2241 2 COG2501 COG2501, Uncharacterized conserved protein Function unknown 19745538 Common - conserved streptococcal hypothetical protein spyM18_0435 3 None None None 19746988 Common mutL DNA mismatch repair protein spyM18_2179 191 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 19746605 Pathogen - hypothetical protein spyM18_1707 1 None None None 19745806 Pathogen - hypothetical protein spyM18_0774 1 None None None 19745838 Common - hypothetical protein spyM18_0809 15 COG4708 COG4708, Predicted membrane protein Function unknown 19745965 Common pyrF orotidine 5'-phosphate decarboxylase spyM18_0959 161 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 19745999 Common - hypothetical protein spyM18_0995 216 COG0628 PerM, Predicted permease General function prediction only 19745813 Common - putative adhesion protein spyM18_0781 171 COG3443 COG3443, Predicted periplasmic or secreted protein General function prediction only 19745529 Common - putative rRNA methylase spyM18_0424 156 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 19746426 Pathogen - hypothetical protein spyM18_1489 1 None None None 19746577 Common - putative amino acid ABC transport system (ATP-binding protein) spyM18_1668 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 19745624 Common pcp pyrrolidone-carboxylate peptidase spyM18_0565 57 COG2039 Pcp, Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase) Posttranslational modification, protein turnover, chaperones 19745738 Common alkH keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase spyM18_0702 126 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 19746556 Common gmk guanylate kinase spyM18_1642 214 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 19745974 Common parC DNA topoisomerase IV subunit A spyM18_0968 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 19745564 Common nrdI ribonucleotide reductase stimulatory protein spyM18_0471 37 COG1780 NrdI, Protein involved in ribonucleotide reduction Nucleotide transport and metabolism 19746324 Common aroK shikimate kinase spyM18_1363 192 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 19746859 Common pnp polynucleotide phosphorylase/polyadenylase spyM18_2014 236 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 19745717 Common ftsW putative cell division protein spyM18_0676 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 19746034 Common - putative two-component response regulator spyM18_1039 186 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 19745280 Common - putative ABC transporter subunit ComYA spyM18_0102 211 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 19746373 Common - hypothetical protein spyM18_1419 63 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 19746232 Common - putative structural phage protein spyM18_1261 7 None None None 19745818 Common flaV flavodoxin spyM18_0788 94 COG0716 FldA, Flavodoxins Energy production and conversion 19745246 Common rplV 50S ribosomal protein L22 spyM18_0056 235 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 19745912 Common - hypothetical protein spyM18_0896 60 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 19745939 Common def peptide deformylase spyM18_0932 168 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 19746837 Common - putative PTS system, lactose-specific component IIA spyM18_1986 32 COG1447 CelC, Phosphotransferase system cellobiose-specific component IIA Carbohydrate transport and metabolism 19746352 Pathogen - hypothetical protein spyM18_1395 1 None None None 19746685 Common - hypothetical protein spyM18_1799 3 None None None 19746233 Common - hypothetical protein spyM18_1262 5 None None None 19747043 Common - N-terminal fragment of a transposase spyM18_2254 4 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 19746114 Common - putative methylmalonyl-CoA decarboxylase, gamma-subunit spyM18_1128 190 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 19745934 Common - hypothetical protein spyM18_0925 5 COG4835 COG4835, Uncharacterized protein conserved in bacteria Function unknown 19745451 Common - hypothetical protein spyM18_0331 13 COG3611 DnaB, Replication initiation/membrane attachment protein DNA replication, recombination, and repair 19746029 Common - hypothetical protein spyM18_1034 8 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 19745907 Common pyrR pyrimidine regulatory protein PyrR spyM18_0890 118 COG2065 PyrR, Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase Nucleotide transport and metabolism 19746796 Common udp putative uridine phosphorylase spyM18_1933 100 COG2820 Udp, Uridine phosphorylase Nucleotide transport and metabolism 19746885 Common spa streptococcal protective antigen spyM18_2046 91 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 19746689 Pathogen - hypothetical protein spyM18_1804 1 None None None 19745437 Common - hypothetical protein spyM18_0314 100 COG1464 NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen Inorganic ion transport and metabolism 19745211 Common hpt hypoxanthine-guanine phosphoribosyltransferase spyM18_0013 155 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 19746514 Common - putative acetate kinase spyM18_1588 4 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 19746736 Common - hypothetical protein spyM18_1861 9 None None None 19746498 Common - hypothetical protein spyM18_1568 12 COG2315 MmcQ, Uncharacterized protein conserved in bacteria Function unknown 19746412 Pathogen - putative structural phage protein spyM18_1471 1 None None None 161484697 Common rplM 50S ribosomal protein L13 spyM18_2000 220 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 19746482 Common - hypothetical protein spyM18_1550 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 19746866 Pathogen - hypothetical protein spyM18_2023 1 None None None 19745498 Common - hypothetical protein spyM18_0384 9 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 19746355 Common alaS alanyl-tRNA synthetase spyM18_1399 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 19745785 Pathogen - hypothetical protein spyM18_0750 1 None None None 19745956 Common clpC putative ATP-dependent Clp proteinase (ATP-binding subunit) spyM18_0949 227 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 19746507 Common valS valyl-tRNA synthetase spyM18_1579 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 19746814 Common - hypothetical protein spyM18_1957 65 COG1073 COG1073, Hydrolases of the alpha/beta superfamily General function prediction only 19746000 Common - hypothetical protein spyM18_0996 25 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 19745941 Common - hypothetical protein spyM18_0934 24 COG2357 COG2357, Uncharacterized protein conserved in bacteria Function unknown 19746022 Common hemN coproporphyrinogen III oxidase spyM18_1022 208 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 19746913 Pathogen - hypothetical protein spyM18_2080 1 None None None 19745491 Pathogen - hypothetical protein spyM18_0375 2 None None None 19745329 Common - putative ABC transporter spyM18_0158 93 COG1744 Med, Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein General function prediction only 19746805 Common glnR putative transcriptional regulator spyM18_1943 44 COG0789 SoxR, Predicted transcriptional regulators Transcription 19746821 Common thiD phosphomethylpyrimidine kinase spyM18_1965 217 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 19746666 Pathogen - hypothetical protein spyM18_1780 2 None None None 19745596 Common - hypothetical protein spyM18_0514 56 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 19745921 Common - hypothetical protein spyM18_0906 17 COG1309 AcrR, Transcriptional regulator Transcription 19746844 Pathogen - hypothetical protein spyM18_1995 1 None None None 19747023 Common - putative L-serine dehydratase alpha subunit spyM18_2225 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 19746393 Pathogen - hypothetical protein spyM18_1451 1 None None None 19746349 Common - putative chloride channel protein spyM18_1390 106 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 19746235 Common - hypothetical protein spyM18_1264 3 None None None 19746333 Common - putative internalin A precursor spyM18_1373 36 COG4886 COG4886, Leucine-rich repeat (LRR) protein Function unknown 19746543 Common - hypothetical protein spyM18_1626 133 COG1739 COG1739, Uncharacterized conserved protein Function unknown 19746385 Common - dihydroorotate dehydrogenase 1A spyM18_1441 222 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 19746216 Common - hypothetical protein spyM18_1241 20 COG3600 GepA, Uncharacterized phage-associated protein Function unknown 19746710 Common - 3-oxoacyl-(acyl carrier protein) synthase III spyM18_1826 210 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 19746583 Common mraW S-adenosyl-methyltransferase MraW spyM18_1676 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 19746267 Pathogen - hypothetical protein spyM18_1296 1 None None None 19745726 Common - hypothetical protein spyM18_0688 2 COG4506 COG4506, Uncharacterized protein conserved in bacteria Function unknown 19746520 Common - putative two-component sensor response regulator spyM18_1595 219 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 19746274 Pathogen - hypothetical protein spyM18_1303 1 COG1396 HipB, Predicted transcriptional regulators Transcription 19745444 Common gidB glucose-inhibited division protein B spyM18_0323 204 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 19745270 Common - hypothetical protein spyM18_0085 2 None None None 19746446 Common - hypothetical protein spyM18_1510 14 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 19746083 Common xpt xanthine phosphoribosyltransferase spyM18_1096 35 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 19746344 Common pts1 putative phosphoenolpyruvate:sugar PTS enzyme I spyM18_1384 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 19746894 Common - putative para-aminobenzoate synthetase spyM18_2056 221 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 19745661 Pathogen - hypothetical protein spyM18_0605 1 COG1493 HprK, Serine kinase of the HPr protein, regulates carbohydrate metabolism Signal transduction mechanisms 19745477 Common - hypothetical protein spyM18_0361 66 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 19746124 Common citE putative citrate lyase, beta subunit spyM18_1139 111 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 19745860 Common rexB putative ATP-dependent exonuclease, subunit B spyM18_0835 27 COG3857 AddB, ATP-dependent nuclease, subunit B DNA replication, recombination, and repair 19746934 Common - putative PTS system, enzyme IIB spyM18_2113 30 COG1440 CelA, Phosphotransferase system cellobiose-specific component IIB Carbohydrate transport and metabolism 19746779 Common - putative esterase spyM18_1913 68 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 19746593 Common - putative NADH peroxidase spyM18_1693 223 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 19746571 Common pepC putative cysteine aminopeptidase C spyM18_1662 17 COG3579 PepC, Aminopeptidase C Amino acid transport and metabolism 19746975 Common - putative oxidoreductase spyM18_2166 67 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 19746243 Common - hypothetical protein spyM18_1272 2 None None None 19746961 Common hutH histidine ammonia-lyase spyM18_2147 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 19746822 Common truA tRNA pseudouridine synthase A spyM18_1966 237 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 19746182 Common - hypothetical protein spyM18_1202 9 COG4129 COG4129, Predicted membrane protein Function unknown 19746642 Common - hypothetical protein spyM18_1750 65 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 19746329 Common - putative acetyl transferase spyM18_1368 68 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 19745578 Pathogen - hypothetical protein spyM18_0491 1 None None None 19746162 Common cdd cytidine deaminase spyM18_1181 119 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 19746584 Pathogen - hypothetical protein spyM18_1678 1 None None None 19746649 Pathogen - N-terminal fragment of hypothetical protein spyM18_1761 1 COG4926 PblB, Phage-related protein Function unknown 19746933 Common - putative PTS system, enzyme IIC component spyM18_2111 38 COG1455 CelB, Phosphotransferase system cellobiose-specific component IIC Carbohydrate transport and metabolism 19745874 Common - hypothetical protein spyM18_0853 23 COG3754 RgpF, Lipopolysaccharide biosynthesis protein Cell envelope biogenesis, outer membrane 19745774 Common - hypothetical protein spyM18_0739 7 None None None 19745424 Common oppD oligopeptide permease spyM18_0284 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 19745636 Common tra transposase-IS1239 spyM18_0577 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 19746904 Common dppC transmembrane transport protein spyM18_2068 221 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 19745882 Common - putative ferredoxin spyM18_0863 3 COG1141 Fer, Ferredoxin Energy production and conversion 19745986 Common - ribonuclease Z spyM18_0981 105 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 19745503 Pathogen - hypothetical protein spyM18_0389 1 None None None 19745843 Common atpF F0F1 ATP synthase subunit B spyM18_0814 145 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 19745469 Pathogen - hypothetical protein spyM18_0352 1 None None None 19746544 Common cysK putative O-acetylserine lyase spyM18_1627 220 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 19746795 Common - putative nucleoside transporter spyM18_1932 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 19746966 Common pepO putative endopeptidase O spyM18_2153 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 19745320 Pathogen - putative V-type Na+ -ATPase subunit E spyM18_0146 2 None None None 19746637 Common - hypothetical protein spyM18_1744 134 COG2252 COG2252, Permeases General function prediction only 19745707 Common - hypothetical protein spyM18_0664 99 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 19746731 Pathogen - hypothetical protein spyM18_1855 1 None None None 19746054 Common potB putative spermidine / putrescine ABC transporter (permease protein) spyM18_1065 199 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 19746368 Common sodA superoxide dismutase spyM18_1414 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 19745779 Pathogen - hypothetical protein spyM18_0744 1 None None None 19745656 Common aroD putative shikimate 5-dehydrogenase spyM18_0600 219 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 19746801 Common - putative glycoprotein endopeptidase spyM18_1939 192 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 19745300 Common nra.1 N-terminal fragment of Nra spyM18_0125 2 None None None 19745603 Common - putative response regulator spyM18_0538 30 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 19746442 Pathogen - hypothetical protein spyM18_1505 2 None None None 19746921 Common - hypothetical protein spyM18_2092 2 None None None 19746387 Common - putative heavy metal-transporting ATPase spyM18_1443 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 19746380 Common ddl D-alanyl-alanine synthetase A spyM18_1431 216 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 19747004 Common - hypothetical protein spyM18_2201 3 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 19745981 Common - putative exfoliative toxin spyM18_0975 11 COG1275 TehA, Tellurite resistance protein and related permeases Inorganic ion transport and metabolism 19747009 Common - hypothetical protein spyM18_2210 61 COG1695 COG1695, Predicted transcriptional regulators Transcription 19746755 Common - hypothetical protein spyM18_1886 30 COG1302 COG1302, Uncharacterized protein conserved in bacteria Function unknown 19745828 Pathogen sagA streptolysin S associated protein spyM18_0799 1 None None None 19745222 Common purM phosphoribosylaminoimidazole synthetase spyM18_0028 235 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 19745369 Common - putative ABC transporter (ATP-binding protein) spyM18_0215 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 19746301 Common ptcA putative PTS enzyme III spyM18_1333 32 COG1447 CelC, Phosphotransferase system cellobiose-specific component IIA Carbohydrate transport and metabolism 19746607 Common acrR putative transcription regulator spyM18_1710 7 COG1309 AcrR, Transcriptional regulator Transcription 19746609 Common - hypothetical protein spyM18_1712 131 COG2860 COG2860, Predicted membrane protein Function unknown 19746471 Common ftsA cell division protein spyM18_1538 185 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 19746193 Common - hypothetical protein spyM18_1215 5 None None None 19745426 Common - putative competence protein spyM18_0300 3 None None None 19746946 Common groEL chaperonin GroEL spyM18_2129 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 19747027 Common - ABC transporter (ATP-binding protein) spyM18_2230 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 19746135 Pathogen - hypothetical protein spyM18_1154 1 None None None 19745997 Common cpsFQ putative dTDP-glucose-4,6-dehydratase spyM18_0993 231 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 19746888 Common - hypothetical protein spyM18_2049 6 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 19745560 Common - putative cell envelope proteinase spyM18_0464 44 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 19745546 Pathogen - hypothetical protein spyM18_0444 1 None None None 19746447 Common - hypothetical protein spyM18_1511 51 COG1307 DegV, Uncharacterized protein conserved in bacteria Function unknown 19745898 Common - hypothetical protein spyM18_0880 62 COG2843 PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) Cell envelope biogenesis, outer membrane 19746857 Common - putative serine acetyltransferase spyM18_2012 190 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 19746059 Common malP putative L-malate permease spyM18_1071 30 COG3493 CitS, Na+/citrate symporter Energy production and conversion 19745879 Common - hypothetical protein spyM18_0860 7 COG4713 COG4713, Predicted membrane protein Function unknown 19746122 Pathogen - hypothetical protein spyM18_1136 2 None None None 19745749 Common - hypothetical protein spyM18_0713 140 COG1660 COG1660, Predicted P-loop-containing kinase General function prediction only 19746632 Common - putative cell-cycle regulation histidine triad (HIT) protein spyM18_1738 232 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 19745744 Common - hypothetical protein spyM18_0708 197 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 19746553 Common fmt methionyl-tRNA formyltransferase spyM18_1638 217 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 19746953 Common - putative NADH oxidase/alkyl hydroperoxidase reductase spyM18_2138 247 COG3634 AhpF, Alkyl hydroperoxide reductase, large subunit Posttranslational modification, protein turnover, chaperones 19746259 Common - hypothetical protein spyM18_1288 2 None None None 19746993 Common - hypothetical protein spyM18_2184 3 None None None 19747013 Common - putative transcriptional regulator spyM18_2214 20 COG1309 AcrR, Transcriptional regulator Transcription 19746453 Common xseB exodeoxyribonuclease VII small subunit spyM18_1517 83 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 19746972 Common - hypothetical protein spyM18_2163 75 COG3022 COG3022, Uncharacterized protein conserved in bacteria Function unknown 19745585 Common - hypothetical protein spyM18_0502 1 None None None 19745248 Common rplP 50S ribosomal protein L16 spyM18_0058 218 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 19745696 Common - hypothetical protein spyM18_0649 12 COG3091 SprT, Uncharacterized protein conserved in bacteria Function unknown 19746064 Common - hypothetical protein spyM18_1076 23 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 19746740 Common - putative ABC transporter (permease) spyM18_1866 191 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 19745239 Common - hypothetical protein spyM18_0048 170 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 19746526 Common - putative transcriptional regulator spyM18_1602 142 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 19746261 Common - hypothetical protein spyM18_1290 3 None None None 19746602 Common - putative reductase / dehydrogenase spyM18_1704 190 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 19745557 Common - putative arsenate reductase spyM18_0459 68 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 19746463 Common - hypothetical protein spyM18_1529 3 None None None 19746726 Common - transcriptional repressor CodY spyM18_1846 20 COG4465 CodY, Pleiotropic transcriptional repressor Transcription 19746517 Pathogen - hypothetical protein spyM18_1591 1 None None None 19745555 Common - hypothetical protein spyM18_0457 2 None None None 19746103 Pathogen - hypothetical protein spyM18_1116 1 None None None 19745569 Pathogen - hypothetical protein spyM18_0480 1 None None None 19746618 Common - putative copper chaperone spyM18_1723 21 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 19746694 Common - hypothetical protein spyM18_1809 110 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 19745642 Common - putative dihydroxyacetone kinase spyM18_0585 77 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 19745979 Common - hypothetical protein spyM18_0973 109 COG1054 COG1054, Predicted sulfurtransferase General function prediction only 19746153 Common - hypothetical protein spyM18_1172 14 COG0095 LplA, Lipoate-protein ligase A Coenzyme metabolism 19745865 Common dnaG DNA primase spyM18_0840 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 19746616 Common - putative PTS system, enzyme IIA component spyM18_1721 10 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 19745858 Common - putative ABC transporter (ATP-binding protein) spyM18_0833 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 19746052 Common murB UDP-N-acetylenolpyruvoylglucosamine reductase spyM18_1063 210 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 19746979 Common - hypothetical protein spyM18_2170 13 COG3906 COG3906, Uncharacterized protein conserved in bacteria Function unknown 19746160 Common - putative sugar ABC transporter (ATP-binding protein) spyM18_1179 249 COG3845 COG3845, ABC-type uncharacterized transport systems, ATPase components General function prediction only 19745536 Common - putative pyruvate-formatelyase activating enzyme spyM18_0433 74 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 19747033 Common hasB UDP-glucose 6-dehydrogenase spyM18_2237 199 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 19746311 Common - putative transposase, IS861 spyM18_1345 136 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 19746674 Common - hypothetical protein spyM18_1788 5 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 19745776 Common - putative methyltransferase spyM18_0741 10 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 19745352 Common - hypothetical protein spyM18_0187 7 COG5523 COG5523, Predicted integral membrane protein Function unknown 19745258 Common rpsE 30S ribosomal protein S5 spyM18_0069 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 19745388 Pathogen - hypothetical protein spyM18_0239 1 COG5578 COG5578, Predicted integral membrane protein Function unknown 19745736 Common - hypothetical protein spyM18_0700 21 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 19746032 Common - putative phospotransferase system (PTS), enzyme II component D spyM18_1037 40 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 19746224 Common - N-terminal fragment of hypothetical phage protein spyM18_1253 2 None None None 19745938 Pathogen - hypothetical protein spyM18_0930 1 None None None 19746687 Common - putative phage DNA replication protein spyM18_1801 34 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 19745815 Common agaS putative tagatose-6-phosphate aldose/ketose isomerase spyM18_0784 36 COG2222 AgaS, Predicted phosphosugar isomerases Cell envelope biogenesis, outer membrane 19745454 Common snf putative SNF helicase spyM18_0335 142 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 19746623 Common infB translation initiation factor IF-2 spyM18_1729 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 19746850 Common - hypothetical protein spyM18_2004 28 COG3688 COG3688, Predicted RNA-binding protein containing a PIN domain General function prediction only 19745626 Common - hypothetical protein spyM18_0567 28 COG3819 COG3819, Predicted membrane protein Function unknown 19745976 Common - hypothetical protein spyM18_0970 1 None None None 19745524 Common scpA segregation and condensation protein A spyM18_0416 138 COG1354 COG1354, Uncharacterized conserved protein Function unknown 19745209 Common - hypothetical protein spyM18_0011 8 COG2367 PenP, Beta-lactamase class A Defense mechanisms 19745420 Common dacA putative penicillin-binding protein spyM18_0280 147 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 19745330 Common nusG transcription antitermination protein NusG spyM18_0159 215 COG0250 NusG, Transcription antiterminator Transcription 19745440 Common - putative branched-chain amino acid transport protein spyM18_0317 50 COG1114 BrnQ, Branched-chain amino acid permeases Amino acid transport and metabolism 19746433 Pathogen - hypothetical protein spyM18_1496 1 None None None 19745475 Common ssb putative single strand binding protein spyM18_0359 210 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 19745932 Pathogen - N-terminal fragment of Sib38 homolgue spyM18_0921 1 None None None 19747021 Common trmU tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase spyM18_2222 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 19745663 Pathogen - hypothetical protein spyM18_0607 1 None None None 19745282 Common - putative competence protein spyM18_0105 3 COG4537 ComGC, Competence protein ComGC Intracellular trafficking and secretion 19745833 Pathogen - hypothetical protein spyM18_0804 1 None None None 19746281 Common - hypothetical protein spyM18_1310 4 None None None 19745762 Pathogen - hypothetical protein spyM18_0727 1 None None None 19746250 Common - hypothetical protein spyM18_1279 4 None None None 19745439 Common - putative ABC transporter (permease protein) spyM18_0316 99 COG2011 AbcD, ABC-type metal ion transport system, permease component Inorganic ion transport and metabolism 19745795 Common - hypothetical protein spyM18_0760 2 None None None 19745970 Common ung uracil-DNA glycosylase spyM18_0964 129 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 19745289 Pathogen - hypothetical protein spyM18_0112 1 None None None 19746781 Common - hypothetical protein spyM18_1915 11 COG0730 COG0730, Predicted permeases General function prediction only 19746704 Common accB acetyl-CoA carboxylase biotin carboxyl carrier protein subunit spyM18_1819 196 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 19745202 Common dnaA chromosomal replication initiation protein spyM18_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 19746303 Common - putative transcriptional antiterminator spyM18_1335 35 COG3711 BglG, Transcriptional antiterminator Transcription 19746130 Common xerS site-specific tyrosine recombinase XerS spyM18_1147 216 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 19746287 Common malG putative maltose/maltodextrin ABC transport system (permease) spyM18_1316 162 COG3833 MalG, ABC-type maltose transport systems, permease component Carbohydrate transport and metabolism 19746220 Pathogen - putative holin spyM18_1247 1 COG5546 COG5546, Small integral membrane protein Function unknown 19745458 Common - putative repressor protein spyM18_0340 16 None None None 19745432 Common - hypothetical protein spyM18_0306 183 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 19745401 Common purR purine operon repressor spyM18_0255 97 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 19745963 Common cpsY putative transcriptional regulator spyM18_0957 175 COG0583 LysR, Transcriptional regulator Transcription 19745621 Common vacB putative exoribonuclease R spyM18_0562 192 COG0557 VacB, Exoribonuclease R Transcription 19745681 Pathogen - hypothetical protein spyM18_0632 1 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 19745887 Common rplT 50S ribosomal protein L20 spyM18_0868 213 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 19745236 Common - putative acyltransferase spyM18_0042 92 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 19745315 Common - hypothetical protein spyM18_0141 176 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 19745275 Common tyrS tyrosyl-tRNA synthetase spyM18_0096 217 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 19746560 Common atoD putative Acetyl-CoA:acetoacetyl-CoA transferase A subunit spyM18_1646 96 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 19745650 Common vicR two-component response regulator spyM18_0594 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 19745381 Common - hypothetical protein spyM18_0230 61 COG1847 Jag, Predicted RNA-binding protein General function prediction only 19745402 Common - putative surface exclusion protein spyM18_0256 3 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 19746986 Common ruvA Holliday junction DNA helicase motor protein spyM18_2177 210 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 19745374 Common - hypothetical protein spyM18_0222 75 COG2013 COG2013, Uncharacterized conserved protein Function unknown 19746719 Common - putative phosphoglycerate mutase spyM18_1836 44 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 19746981 Common - hypothetical protein spyM18_2172 24 COG4472 COG4472, Uncharacterized protein conserved in bacteria Function unknown 19746391 Common - hypothetical protein spyM18_1448 67 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 19745741 Common prfB peptide chain release factor 2 spyM18_0705 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 19746209 Common - putative ABC transporter spyM18_1234 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 19745962 Pathogen - histidine protein kinase spyM18_0956 1 None None None 19745885 Common infC translation initiation factor IF-3 spyM18_0866 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 19746880 Common - multiple sugar-binding ABC transport system (ATP-binding protein) spyM18_2040 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 19745849 Common - hypothetical protein spyM18_0820 1 None None None 19746304 Common - hypothetical protein spyM18_1336 17 COG3589 COG3589, Uncharacterized conserved protein Function unknown 19746936 Common - putative transcriptional regulator spyM18_2115 69 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 19745844 Common atpH F0F1 ATP synthase subunit delta spyM18_0815 70 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 19746204 Common - putative signal peptidase I spyM18_1229 59 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 19746342 Common deadD2 putative deacetylase spyM18_1382 103 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 19745715 Common pepF putative oligopeptidase spyM18_0673 84 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 19746297 Common glnQ putative ABC transporter (ATP-binding protein) spyM18_1328 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 19746339 Common - hypothetical protein spyM18_1379 3 COG3326 COG3326, Predicted membrane protein Function unknown 19747007 Common - hypothetical protein spyM18_2207 26 COG2035 COG2035, Predicted membrane protein Function unknown 19746806 Common - hypothetical protein spyM18_1944 4 COG4129 COG4129, Predicted membrane protein Function unknown 19745306 Common - putative multiple sugar metabolism repressor spyM18_0131 66 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 19745446 Common htpX heat shock protein HtpX spyM18_0325 188 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 19746887 Common nrdI hypothetical protein spyM18_2048 26 COG1780 NrdI, Protein involved in ribonucleotide reduction Nucleotide transport and metabolism 19745983 Common miaA tRNA delta(2)-isopentenylpyrophosphate transferase spyM18_0978 214 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 19746180 Common truB tRNA pseudouridine synthase B spyM18_1200 245 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 19746483 Common - hypothetical protein spyM18_1551 11 COG4470 COG4470, Uncharacterized protein conserved in bacteria Function unknown 19746404 Pathogen - hypothetical protein spyM18_1463 1 None None None 19746123 Common citD citrate lyase subunit gamma spyM18_1137 25 COG3052 CitD, Citrate lyase, gamma subunit Energy production and conversion 19745880 Common pepT peptidase T spyM18_0861 59 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 19745775 Pathogen - hypothetical protein spyM18_0740 1 None None None 19746050 Common folQ dihydroneopterin aldolase spyM18_1061 120 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 19745631 Common tra transposase-IS1239 spyM18_0572 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 19745462 Common - putative antirepressor spyM18_0344 38 COG3617 COG3617, Prophage antirepressor Transcription 19746040 Common trmE tRNA modification GTPase TrmE spyM18_1045 225 COG0486 ThdF, Predicted GTPase General function prediction only 19746973 Common nrdG putative anaerobic ribonucleotide reductase activator spyM18_2164 64 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 161484699 Common murG N-acetylglucosaminyl transferase spyM18_1541 207 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 19746327 Common map methionine aminopeptidase spyM18_1366 240 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 19746170 Common pstB1 phosphate ABC transporter (ATP-binding protein) spyM18_1190 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 19745614 Pathogen - hypothetical protein spyM18_0551 1 None None None 19746047 Common folC putative folyl-polyglutamate synthetase spyM18_1058 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 19746778 Common pfl putative pyruvate formate-lyase spyM18_1912 55 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 19745948 Common mvaS1 HMG-CoA reductase spyM18_0941 53 COG1257 HMG1, Hydroxymethylglutaryl-CoA reductase Lipid metabolism 19746654 Common - putative major tail shaft protein spyM18_1766 2 None None None 19745508 Common - hypothetical protein spyM18_0396 1 None None None 19745871 Common - putative ABC-transporter (permease protein) spyM18_0848 92 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 19746622 Common rbfA ribosome-binding factor A spyM18_1728 165 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 19745787 Pathogen - hypothetical protein spyM18_0752 1 None None None 19745863 Common rpsU 30S ribosomal protein S21 spyM18_0838 95 None None None 19745415 Common - hypothetical protein spyM18_0275 181 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 19746572 Common nadE NAD synthetase spyM18_1663 139 COG0171 NadE, NAD synthase Coenzyme metabolism 19745505 Common - putative N-acetylmuramoyl-L-alanine amidase spyM18_0391 4 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 19746629 Common - hypothetical protein spyM18_1735 11 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 19746868 Common def peptide deformylase spyM18_2025 211 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 19745638 Common - hypothetical protein spyM18_0580 39 COG4587 COG4587, ABC-type uncharacterized transport system, permease component General function prediction only 19746793 Common - hypothetical protein spyM18_1930 142 COG2081 COG2081, Predicted flavoproteins General function prediction only 19745319 Common - V-type ATP synthase subunit K spyM18_0145 18 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 19746586 Common proB gamma-glutamyl kinase spyM18_1681 192 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 19746840 Common - galactose-6-phosphate isomerase subunit LacB spyM18_1990 97 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 19746968 Common - putative PTS system enzyme II spyM18_2155 60 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 19746366 Common - hypothetical protein spyM18_1412 1 None None None 19746676 Pathogen - hypothetical protein spyM18_1790 1 None None None 19745857 Common - hypothetical protein spyM18_0832 14 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 19746528 Common hyl putative hyaluronidase spyM18_1606 13 None None None 19746635 Common - hypothetical protein spyM18_1742 42 COG0456 RimI, Acetyltransferases General function prediction only 19745478 Pathogen - hypothetical protein spyM18_0362 1 None None None 19746466 Common - hypothetical protein spyM18_1533 31 COG2302 COG2302, Uncharacterized conserved protein, contains S4-like domain Function unknown 19746005 Common - putative ABC transporter (ATP-binding protein) spyM18_1002 249 COG1101 PhnK, ABC-type uncharacterized transport system, ATPase component General function prediction only 19745662 Common - hypothetical protein spyM18_0606 15 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 19746855 Pathogen - hypothetical protein spyM18_2009 1 None None None 19745754 Common - putative repressor protein spyM18_0718 28 COG2932 COG2932, Predicted transcriptional regulator Transcription 19745724 Pathogen - hypothetical protein spyM18_0686 1 None None None 19745620 Common secG preprotein translocase subunit SecG spyM18_0561 1 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 19745780 Pathogen - hypothetical protein spyM18_0745 1 COG0338 Dam, Site-specific DNA methylase DNA replication, recombination, and repair 19745922 Common rimM 16S rRNA-processing protein spyM18_0907 131 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 19745782 Common - hypothetical protein spyM18_0747 10 COG1724 COG1724, Predicted periplasmic or secreted lipoprotein Cell motility and secretion 19746669 Common - hypothetical protein spyM18_1783 3 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 19746383 Common - putative transcriptional regulator spyM18_1437 16 COG1827 COG1827, Predicted small molecule binding protein (contains 3H domain) General function prediction only 19745605 Pathogen - hypothetical protein spyM18_0540 1 None None None 19745224 Common purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase spyM18_0030 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 19746696 Common - putative mannose-specific phosphotransferase system component II spyM18_1811 35 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 19745665 Common - putative efflux protein spyM18_0609 78 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 19746334 Common birA biotin--protein ligase spyM18_1374 171 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 19745326 Common - putative toxic anion resistance protein spyM18_0154 18 COG3853 TelA, Uncharacterized protein involved in tellurite resistance Inorganic ion transport and metabolism 19745216 Common recO DNA repair protein RecO spyM18_0022 34 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 19745733 Common - putative unsaturated glucuronyl hydrolase spyM18_0697 21 COG4225 COG4225, Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins General function prediction only 19745390 Common - putative glucose kinase spyM18_0241 129 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 19745677 Common - asparagine synthetase A spyM18_0624 97 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 19746892 Common - hypothetical protein spyM18_2053 4 None None None 19746597 Common - hypothetical protein spyM18_1698 2 COG3212 COG3212, Predicted membrane protein Function unknown 19746874 Common cdsA putative phosphatidate cytidylyltransferase spyM18_2032 215 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 19745511 Common - putative aminodeoxychorismate lyase spyM18_0401 186 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 19746990 Common - hypothetical protein spyM18_2181 2 COG4550 COG4550, Predicted membrane protein Function unknown 19747020 Common - hypothetical protein spyM18_2221 5 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 19746009 Common - putative ABC transporter (ATP-binding protein) spyM18_1008 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 19745905 Common lspA putative prolipoprotein signal peptidase spyM18_0888 138 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 19746914 Common isp immunogenic secreted protein precursor spyM18_2082 9 COG3942 COG3942, Surface antigen General function prediction only 19746761 Common - hypothetical protein spyM18_1894 8 COG4858 COG4858, Uncharacterized membrane-bound protein conserved in bacteria Function unknown 19745629 Common - putative NAD(P)H-flavin oxidoreductase spyM18_0570 94 COG0778 NfnB, Nitroreductase Energy production and conversion 19745812 Common - putative dipeptidase spyM18_0780 24 COG4690 PepD, Dipeptidase Amino acid transport and metabolism 19746906 Common dppE ATPase protein spyM18_2070 249 COG1124 DppF, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 19746816 Common rpoE DNA-directed RNA polymerase subunit delta spyM18_1960 12 COG3343 RpoE, DNA-directed RNA polymerase, delta subunit Transcription 19745770 Pathogen - hypothetical protein spyM18_0735 1 None None None 19745731 Common - putative PTS dependent N-acetyl-galactosamine-IIC component spyM18_0695 36 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 19746648 Pathogen hylP hyaluronidase spyM18_1757 1 None None None 19745210 Common mesJ putative cell-cycle protein spyM18_0012 204 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 19747024 Common - hypothetical protein spyM18_2226 2 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 19746359 Common pepB putative oligopeptidase spyM18_1403 85 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 19746876 Common yajC preprotein translocase subunit YajC spyM18_2035 8 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 19745395 Common - ribosome-associated GTPase spyM18_0247 163 COG1162 COG1162, Predicted GTPases General function prediction only 19746177 Common - hypothetical protein spyM18_1197 11 COG4476 COG4476, Uncharacterized protein conserved in bacteria Function unknown 19745397 Common - hypothetical protein spyM18_0249 25 COG1564 THI80, Thiamine pyrophosphokinase Coenzyme metabolism 19745327 Pathogen - hypothetical protein spyM18_0155 1 None None None 19746322 Common - putative RNA methyltransferase spyM18_1360 197 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 19745954 Common - GTPase EngB spyM18_0947 193 COG0218 COG0218, Predicted GTPase General function prediction only 19746347 Common nrdE ribonucleotide-diphosphate reductase subunit alpha spyM18_1387 216 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 19745918 Common - hypothetical protein spyM18_0903 16 None None None 19746849 Common - hypothetical protein spyM18_2003 54 COG1307 DegV, Uncharacterized protein conserved in bacteria Function unknown 19745622 Common smpB SsrA-binding protein spyM18_0563 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 19746509 Pathogen - hypothetical protein spyM18_1582 2 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 19745972 Common - hypothetical protein spyM18_0966 170 COG0344 COG0344, Predicted membrane protein Function unknown 19746537 Common - hypothetical protein spyM18_1619 2 None None None 19746834 Pathogen - lantibiotic precursor spyM18_1983 1 None None None 19745990 Common - hypothetical protein spyM18_0985 19 COG3935 DnaD, Putative primosome component and related proteins DNA replication, recombination, and repair 19746356 Common prsA foldase protein PrsA spyM18_1400 12 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 19746421 Pathogen - hypothetical protein spyM18_1484 1 COG1403 McrA, Restriction endonuclease Defense mechanisms 19745793 Pathogen - hypothetical protein spyM18_0758 1 None None None 19746015 Common - putative lipoate-protein ligase spyM18_1015 82 COG0095 LplA, Lipoate-protein ligase A Coenzyme metabolism 19746789 Common - hypothetical protein spyM18_1926 32 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 19745234 Common - putative protein-tyrosine phosphatase spyM18_0040 116 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 19746286 Common malF putative maltose/maltodextrin ABC transport system (permease) spyM18_1315 153 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 19745526 Common - hypothetical protein spyM18_0418 207 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 19746428 Pathogen - hypothetical protein spyM18_1491 1 None None None 19746067 Common radC DNA repair protein RadC spyM18_1079 178 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 19746567 Common - hypothetical protein spyM18_1658 12 COG3599 DivIVA, Cell division initiation protein Cell division and chromosome partitioning 19746028 Common - hypothetical protein spyM18_1033 119 COG2855 COG2855, Predicted membrane protein Function unknown 19746749 Common - putative fructokinase spyM18_1877 32 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 19745942 Common - putative two-component response regulator spyM18_0935 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 19746765 Pathogen - hypothetical protein spyM18_1898 1 None None None 19745273 Common adrB putative ABC transporter (permease) spyM18_0094 177 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 19746984 Common cinA competence damage-inducible protein A spyM18_2175 212 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 19745809 Common - hypothetical protein spyM18_0777 67 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 19746702 Common accC acetyl-CoA carboxylase biotin carboxylase subunit spyM18_1817 234 COG0439 AccC, Biotin carboxylase Lipid metabolism 19745409 Common - putative glutamine-binding periplasmic protein spyM18_0264 174 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 19745839 Common ligA NAD-dependent DNA ligase LigA spyM18_0810 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 19746568 Common - hypothetical protein spyM18_1659 11 COG4474 COG4474, Uncharacterized protein conserved in bacteria Function unknown 19746641 Pathogen - hypothetical protein spyM18_1749 1 None None None 19746079 Common - hypothetical protein spyM18_1091 2 None None None 19745802 Common - hypothetical protein spyM18_0769 5 COG4926 PblB, Phage-related protein Function unknown 19745684 Common - transposase fragment spyM18_0635 34 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 19746928 Common - mitogenic factor, 25K, precursor spyM18_2104 4 None None None 19745516 Common - hypothetical protein spyM18_0407 11 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 19745423 Common oppC oligopeptide permease spyM18_0283 219 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 19746681 Common ssb putative single strand binding protein spyM18_1795 213 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 19746088 Common prfA peptide chain release factor 1 spyM18_1101 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 19745730 Common - putative PTS dependent galactosamine IID component spyM18_0694 40 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 19745452 Common - primosomal protein DnaI spyM18_0332 40 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 19746445 Common - hypothetical protein spyM18_1509 11 COG4698 COG4698, Uncharacterized protein conserved in bacteria Function unknown 19746003 Pathogen - hypothetical protein spyM18_1000 1 None None None 19746899 Pathogen - hypothetical protein spyM18_2063 1 None None None 19745936 Common papS tRNA CCA-pyrophosphorylase spyM18_0927 214 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 19745265 Common rpsM 30S ribosomal protein S13 spyM18_0077 242 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 19746127 Common oadA oxaloacetate decarboxylase spyM18_1142 175 COG5016 COG5016, Pyruvate/oxaloacetate carboxyltransferase Energy production and conversion 19745476 Pathogen - hypothetical protein spyM18_0360 2 COG1396 HipB, Predicted transcriptional regulators Transcription 19745456 Pathogen - hypothetical protein spyM18_0338 2 None None None 19746843 Pathogen - hypothetical protein spyM18_1994 1 None None None 19745294 Common trxA putative thioredoxin spyM18_0118 68 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 19745345 Common - putative transcriptional regulator spyM18_0179 33 COG3711 BglG, Transcriptional antiterminator Transcription 19745959 Common arsC putative arsenate reductase spyM18_0952 105 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 19746268 Pathogen - hypothetical protein spyM18_1297 1 None None None 19745472 Common - hypothetical protein spyM18_0356 4 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 19746237 Pathogen - hypothetical protein spyM18_1266 1 None None None 19746110 Common topA DNA topoisomerase I spyM18_1124 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 19745354 Common - hypothetical protein spyM18_0191 14 COG4357 COG4357, Uncharacterized conserved protein Function unknown 19746594 Common glpF putative glycerol uptake facilitator spyM18_1694 129 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 19745207 Common - hypothetical protein spyM18_0008 44 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 19746481 Pathogen - hypothetical protein spyM18_1549 1 None None None 19746824 Common - hypothetical protein spyM18_1973 81 COG1929 COG1929, Glycerate kinase Carbohydrate transport and metabolism 19746630 Common - putative ABC transporter (permease) spyM18_1736 12 COG4473 EcsB, Predicted ABC-type exoprotein transport system, permease component Intracellular trafficking and secretion 19746252 Common - hypothetical protein spyM18_1281 4 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 19745430 Common nadD nicotinic acid mononucleotide adenyltransferase spyM18_0304 187 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 19746457 Common - putative deoxyribodipyrimidine photolyase spyM18_1523 135 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 19746149 Common - hypothetical protein spyM18_1168 105 COG2110 COG2110, Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 General function prediction only 19746225 Common hylP hyaluronidase spyM18_1254 2 None None None 19745591 Common msrA methionine sulfoxide reductase A spyM18_0509 205 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 19746521 Common - putative two-component sensor histidine kinase spyM18_1596 101 COG2972 COG2972, Predicted signal transduction protein with a C-terminal ATPase domain Signal transduction mechanisms 19746188 Common - putative transcriptional regulator spyM18_1210 20 COG0490 COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels Inorganic ion transport and metabolism 19745725 Common - hypothetical protein spyM18_0687 86 COG1078 COG1078, HD superfamily phosphohydrolases General function prediction only 19746941 Common tdcF hypothetical protein spyM18_2121 4 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 19746467 Common - hypothetical protein spyM18_1534 17 COG0762 COG0762, Predicted integral membrane protein Function unknown 19746905 Common dppD ATPase protein spyM18_2069 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 19745418 Common - hypothetical protein spyM18_0278 185 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 19746175 Common - putative nucleolar protein spyM18_1195 207 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 19746945 Common - putative dipeptidase spyM18_2126 21 COG4690 PepD, Dipeptidase Amino acid transport and metabolism 19745362 Common pgi glucose-6-phosphate isomerase spyM18_0204 193 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 19746214 Pathogen - putative exotoxin precursor (SpeM) spyM18_1239 2 None None None 19746656 Pathogen - hypothetical protein spyM18_1769 1 None None None 19746519 Common - putative beta-galactosidase spyM18_1594 70 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 19746541 Common - putative late competence protein spyM18_1624 31 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 19745256 Common rplF 50S ribosomal protein L6 spyM18_0067 246 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 19746660 Pathogen - hypothetical protein spyM18_1774 2 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 19745337 Common - putative cystathionine beta-lyase spyM18_0170 207 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 19745894 Common folC putative folyl-polyglutamate synthetase spyM18_0876 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 19745521 Common - hypothetical protein spyM18_0413 39 COG0622 COG0622, Predicted phosphoesterase General function prediction only 19746085 Common - putative thiamine biosynthesis lipoprotein precursor spyM18_1098 129 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 19746058 Common - putative two-component sensor histidine kinase spyM18_1069 41 COG3290 CitA, Signal transduction histidine kinase regulating citrate/malate metabolism Signal transduction mechanisms 19746266 Pathogen - hypothetical protein spyM18_1295 1 COG1497 COG1497, Predicted transcriptional regulator Transcription 19746101 Common - hypothetical protein spyM18_1114 42 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 19745485 Common - hypothetical protein spyM18_0369 40 COG4626 COG4626, Phage terminase-like protein, large subunit General function prediction only 19746865 Common rpsO 30S ribosomal protein S15 spyM18_2021 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 19746191 Common - hypothetical protein spyM18_1213 37 COG1302 COG1302, Uncharacterized protein conserved in bacteria Function unknown 19746627 Common - hypothetical protein spyM18_1733 136 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 19746246 Common - hypothetical protein spyM18_1275 7 COG5585 COG5585, NAD+--asparagine ADP-ribosyltransferase Signal transduction mechanisms 19746066 Common - hypothetical protein spyM18_1078 96 COG0628 PerM, Predicted permease General function prediction only 19745768 Common - hypothetical protein spyM18_0733 5 None None None 19745442 Common - hypothetical protein spyM18_0320 117 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 19746950 Common - putative transcriptional regulator spyM18_2135 22 COG4463 CtsR, Transcriptional repressor of class III stress genes Transcription 19745709 Common - putative transcription regulator spyM18_0666 99 COG2606 EbsC, Uncharacterized conserved protein Function unknown 19746163 Common - hypothetical protein spyM18_1182 106 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 19746155 Common dfp phosphopantothenoylcysteine decarboxylase spyM18_1174 235 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 19747030 Common - hypothetical protein spyM18_2233 90 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 19745900 Common rplU 50S ribosomal protein L21 spyM18_0883 131 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 19746574 Common - putative amino acid permease spyM18_1665 136 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 19746142 Common - hypothetical protein spyM18_1161 161 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 19746601 Common - hypothetical protein spyM18_1703 16 COG1755 COG1755, Uncharacterized protein conserved in bacteria Function unknown 19746109 Common smf putative DNA processing protein spyM18_1123 211 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 19746614 Common - putative PTS system, enzyme IIC component spyM18_1719 19 COG3775 GatC, Phosphotransferase system, galactitol-specific IIC component Carbohydrate transport and metabolism 19745695 Common - hypothetical protein spyM18_0648 209 COG2183 Tex, Transcriptional accessory protein Transcription 19746971 Common - N-terminal fragment of a hypothetical protein spyM18_2161 17 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 19745544 Common - hypothetical protein spyM18_0442 28 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 19745583 Common cypB putative cyclophilin-type protein spyM18_0499 201 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 19746097 Common nox NADH Oxidase spyM18_1110 247 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 19745769 Pathogen - hypothetical protein spyM18_0734 1 None None None 19746477 Common - hypothetical protein spyM18_1545 28 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 19746551 Common - putative phosphoprotein phosphatase spyM18_1635 131 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 19746431 Common - hypothetical protein spyM18_1494 5 None None None 19746730 Common - putative L-asparaginase spyM18_1853 139 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 19746978 Common - hypothetical protein spyM18_2169 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 19745332 Pathogen - hypothetical protein spyM18_0164 1 None None None 19746451 Common - putative hemolysin spyM18_1515 130 COG1189 COG1189, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 19745535 Common hylX putative hemolysin spyM18_0432 219 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 19747019 Common gidA tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA spyM18_2220 191 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 19745985 Common - hypothetical protein spyM18_0980 2 COG4468 GalT, Galactose-1-phosphate uridyltransferase Carbohydrate transport and metabolism 161484703 Common pheS phenylalanyl-tRNA synthetase subunit alpha spyM18_0827 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 19746253 Pathogen - hypothetical protein spyM18_1282 1 None None None 19746531 Common - hypothetical protein spyM18_1611 48 COG0383 AMS1, Alpha-mannosidase Carbohydrate transport and metabolism 19745413 Common rgpG putative regulator of genetic competence spyM18_0270 225 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 19746313 Common - putative integral membrane protein spyM18_1347 20 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 19746939 Common secE preprotein translocase subunit SecE spyM18_2119 2 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 19746772 Common - hypothetical protein spyM18_1905 2 None None None 19746558 Common - putative transcriptional regulator spyM18_1644 178 COG0583 LysR, Transcriptional regulator Transcription 19746033 Common - putative two-component sensor histidine kinase spyM18_1038 103 COG2972 COG2972, Predicted signal transduction protein with a C-terminal ATPase domain Signal transduction mechanisms 19746750 Pathogen - secreted endoglycosidase spyM18_1880 3 None None None 19745824 Common gyrB DNA gyrase subunit B spyM18_0795 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 19746306 Common - hypothetical protein spyM18_1339 9 COG3201 PnuC, Nicotinamide mononucleotide transporter Coenzyme metabolism 19745588 Common pyrH uridylate kinase spyM18_0505 230 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 19746168 Common pepN putative lysyl-aminopeptidase spyM18_1188 166 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 19746172 Common pstA putative phosphate ABC transporter (permease protein) spyM18_1192 230 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 19746320 Common - hypothetical protein spyM18_1358 13 COG2820 Udp, Uridine phosphorylase Nucleotide transport and metabolism 19745348 Common - putative glycine-betaine binding permease protein spyM18_0182 175 COG4176 ProW, ABC-type proline/glycine betaine transport system, permease component Amino acid transport and metabolism 19746930 Common gldA glycerol dehydrogenase spyM18_2108 142 COG0371 GldA, Glycerol dehydrogenase and related enzymes Energy production and conversion 19746221 Pathogen - hypothetical protein spyM18_1248 1 None None None 19746357 Common - putative methyltransferase spyM18_1401 104 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 19746633 Common - hypothetical protein spyM18_1739 1 None None None 19746717 Common - putative N-acetyl-muramidase spyM18_1834 19 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 19745616 Common - formamidopyrimidine-DNA glycosylase spyM18_0555 182 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 19746620 Common - putative negative transcriptional regulator spyM18_1726 21 COG3682 COG3682, Predicted transcriptional regulator Transcription 19746578 Common - putative amino acid ABC transproter (permease protein) spyM18_1669 173 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 19746652 Common - hypothetical protein spyM18_1764 2 None None None 19745946 Common - phosphomevalonate kinase spyM18_0939 13 COG1577 ERG12, Mevalonate kinase Lipid metabolism 19747039 Common trpS tryptophanyl-tRNA synthetase II spyM18_2245 248 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 19746460 Common - hypothetical protein spyM18_1526 5 COG4703 COG4703, Uncharacterized protein conserved in bacteria Function unknown 19746362 Common nagB putative N-acetylglucosamine-6-phosphate isomerase spyM18_1407 83 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 19745268 Common rplQ 50S ribosomal protein L17 spyM18_0080 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 19745652 Common vicX hypothetical protein spyM18_0596 59 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 19745859 Common - hypothetical protein spyM18_0834 88 COG2321 COG2321, Predicted metalloprotease General function prediction only 19746680 Common - hypothetical protein spyM18_1794 10 COG4570 Rus, Holliday junction resolvase DNA replication, recombination, and repair 19745916 Common rpsP 30S ribosomal protein S16 spyM18_0900 213 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 19747005 Common - hypothetical protein spyM18_2202 3 None None None 19745480 Pathogen - hypothetical protein spyM18_0364 1 None None None 19746861 Common ulaA ascorbate-specific PTS system enzyme IIC spyM18_2016 36 COG3037 SgaT, Uncharacterized protein conserved in bacteria Function unknown 19746364 Common - hypothetical protein spyM18_1409 4 None None None 19746962 Common - putative formiminoglutamate hydrolase spyM18_2148 137 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 19745703 Common - putative protease spyM18_0659 114 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 19745747 Common aspC aspartate aminotransferase spyM18_0711 240 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 19746722 Common gatB aspartyl/glutamyl-tRNA amidotransferase subunit B spyM18_1839 214 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 19745364 Common - hypothetical protein spyM18_0208 67 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 19746046 Common tra putative transposase spyM18_1057 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 19746548 Common - putative two-component sensor histidine kinase spyM18_1631 138 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 19745842 Common atpB F0F1 ATP synthase subunit A spyM18_0813 205 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 19745253 Common rplE 50S ribosomal protein L5 spyM18_0064 247 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 19745869 Common - hypothetical protein spyM18_0845 27 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 19746489 Common - carbamate kinase spyM18_1558 65 COG0549 ArcC, Carbamate kinase Amino acid transport and metabolism 19746889 Common ptsG putative PTS system, enzyme II, A component spyM18_2050 60 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 19745892 Common - hypothetical protein spyM18_0873 18 COG3679 COG3679, Uncharacterized conserved protein Function unknown 19746292 Common - putative integral membrane protein spyM18_1323 86 COG1696 DltB, Predicted membrane protein involved in D-alanine export Cell envelope biogenesis, outer membrane 19746014 Common hylA extracellular hyaluronate lyase spyM18_1014 11 None None None 19746799 Common - O-sialoglycoprotein endopeptidase spyM18_1937 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 19745854 Common - hypothetical protein spyM18_0829 1 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 19746202 Common - hypothetical protein spyM18_1226 105 COG2824 PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism Inorganic ion transport and metabolism 19745808 Pathogen - putative holin spyM18_0776 1 COG5546 COG5546, Small integral membrane protein Function unknown 19746299 Common - putative PTS system IIC component spyM18_1331 38 COG1455 CelB, Phosphotransferase system cellobiose-specific component IIC Carbohydrate transport and metabolism 19745241 Common rplC 50S ribosomal protein L3 spyM18_0050 249 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 19746293 Common dltA D-alanine--D-alanyl carrier protein ligase spyM18_1324 222 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 19746073 Common - hypothetical protein spyM18_1085 9 COG4116 COG4116, Uncharacterized protein conserved in bacteria Function unknown 19745848 Common atpC F0F1 ATP synthase subunit epsilon spyM18_0819 125 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 19745640 Common - putative dihydroxyacetone kinase spyM18_0583 77 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 19745227 Common purE phosphoribosylaminoimidazole carboxylase catalytic subunit spyM18_0033 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 19746811 Common - putative alkaline-shock protein spyM18_1951 35 COG1302 COG1302, Uncharacterized protein conserved in bacteria Function unknown 19745376 Common - putative histidine kinase spyM18_0224 12 COG2972 COG2972, Predicted signal transduction protein with a C-terminal ATPase domain Signal transduction mechanisms 19745649 Common - hypothetical protein spyM18_0593 4 None None None 19746882 Pathogen - streptokinase precursor spyM18_2042 1 None None None 19747002 Common - putative cadmium resistance protein spyM18_2198 19 COG4300 CadD, Predicted permease, cadmium resistance protein Inorganic ion transport and metabolism 19746879 Common - putative dextran glucosidase spyM18_2039 156 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 19745756 Pathogen - hypothetical protein spyM18_0721 1 None None None 19745304 Common - hypothetical protein spyM18_0129 5 COG4509 COG4509, Uncharacterized protein conserved in bacteria Function unknown 19746872 Common proS prolyl-tRNA synthetase spyM18_2030 235 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 19746337 Common - hypothetical protein spyM18_1377 84 COG1956 COG1956, GAF domain-containing protein Signal transduction mechanisms 19745358 Common - hypothetical protein spyM18_0197 7 COG5279 CYK3, Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain Cell division and chromosome partitioning 19746916 Common - putative two-component response regulator spyM18_2084 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 19745448 Common covR CovR spyM18_0328 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 19746340 Common udk uridine kinase spyM18_1380 81 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 19746742 Common - hypothetical protein spyM18_1868 34 COG4886 COG4886, Leucine-rich repeat (LRR) protein Function unknown 19746724 Common gatC aspartyl/glutamyl-tRNA amidotransferase subunit C spyM18_1841 126 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 19746430 Pathogen - hypothetical protein spyM18_1493 1 None None None 19746493 Common - hypothetical protein spyM18_1563 20 COG2153 ElaA, Predicted acyltransferase General function prediction only 19746450 Common argR putative repressor protein spyM18_1514 15 COG1438 ArgR, Arginine repressor Transcription 19746808 Common - putative acid phosphatase spyM18_1947 28 COG2503 COG2503, Predicted secreted acid phosphatase General function prediction only 19746332 Common metK S-adenosylmethionine synthetase spyM18_1372 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 19745832 Common - hypothetical protein spyM18_0803 3 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 19745607 Common - putative transport ATP-binding protein spyM18_0543 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 19746599 Common glyS glycyl-tRNA synthetase subunit beta spyM18_1700 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 19745218 Common acp acyl carrier protein spyM18_0024 89 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 19746818 Common - hypothetical protein spyM18_1962 133 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 19745952 Common - hypothetical protein spyM18_0945 2 None None None 19745777 Common - hypothetical protein spyM18_0742 69 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 19746878 Common - putative pullulanase spyM18_2038 152 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 19746853 Common - hypothetical protein spyM18_2007 38 COG1939 COG1939, Uncharacterized protein conserved in bacteria Function unknown 19746019 Common - hypothetical protein spyM18_1019 14 COG4856 COG4856, Uncharacterized protein conserved in bacteria Function unknown 19745929 Common fruA putative fructose-specific enzyme II, PTS system BC component spyM18_0914 141 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 19745393 Common - hypothetical protein spyM18_0244 21 COG1658 COG1658, Small primase-like proteins (Toprim domain) DNA replication, recombination, and repair 19745903 Pathogen - hypothetical protein spyM18_0886 1 None None None 19745878 Common - hypothetical protein spyM18_0859 21 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 19745495 Pathogen - hypothetical protein spyM18_0380 1 None None None 19745737 Common kdgK putative 2-keto-3-deoxygluconate kinase spyM18_0701 72 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 19746007 Common estA putative tributyrin esterase spyM18_1005 49 COG0627 COG0627, Predicted esterase General function prediction only 19746179 Common - bifunctional riboflavin kinase/FMN adenylyltransferase spyM18_1199 211 COG0196 RibF, FAD synthase Coenzyme metabolism 19746908 Pathogen - hypothetical protein spyM18_2072 1 None None None 19746662 Pathogen - hypothetical protein spyM18_1776 1 None None None 19746678 Common - hypothetical protein spyM18_1792 5 None None None 19746659 Common - putative major head protein spyM18_1772 5 None None None 19746999 Common - putative transposase spyM18_2190 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 19745317 Pathogen - hypothetical protein spyM18_0143 1 None None None 19745928 Common fruK putative fructose-1-phosphate kinase spyM18_0913 111 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 19745861 Common rexA putative ATP-dependent exonuclease, subunit A spyM18_0836 229 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 19746500 Common - putative two-component response regulator spyM18_1570 224 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 19745460 Pathogen - hypothetical protein spyM18_0342 1 None None None 19746416 Pathogen - hypothetical protein spyM18_1476 1 None None None 19745722 Common femB putative peptidoglycan branched peptide synthesis protein, serine/alanine adding enzyme spyM18_0683 22 COG2348 COG2348, Uncharacterized protein involved in methicillin resistance Defense mechanisms 19746831 Common - putative ABC transporter (permease) spyM18_1980 5 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 19746278 Pathogen - hypothetical protein spyM18_1307 2 None None None 19745789 Common - OrfH-like protein spyM18_0754 28 COG4695 COG4695, Phage-related protein Function unknown 19746732 Common - putative ABC transporter (ATP-binding protein) spyM18_1856 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 19745551 Common - hypothetical protein spyM18_0451 1 None None None 19746757 Common - putative late competence protein spyM18_1888 104 COG2131 ComEB, Deoxycytidylate deaminase Nucleotide transport and metabolism 19746898 Common - topology modulation protein spyM18_2061 35 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 19746091 Common - hypothetical protein spyM18_1104 8 COG0456 RimI, Acetyltransferases General function prediction only 19745206 Common trcF putative transcription-repair coupling factor spyM18_0007 231 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 19745493 Pathogen - hypothetical protein spyM18_0378 1 None None None 19746683 Common - hypothetical protein spyM18_1797 8 None None None 19745876 Common - putative glycosyl transferase spyM18_0856 183 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 19746230 Common - hypothetical protein spyM18_1259 3 None None None 19746919 Common - putative ATP-binding cassette transporter-like protein spyM18_2090 29 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 19746121 Common - putative decarboxylase, beta subunit spyM18_1135 56 COG1883 OadB, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit Energy production and conversion 19746925 Pathogen - hypothetical protein spyM18_2101 1 None None None 19746025 Common - hypothetical protein spyM18_1025 8 COG4478 COG4478, Predicted membrane protein Function unknown 19746165 Common rpsT 30S ribosomal protein S20 spyM18_1184 154 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 19746198 Pathogen cfa CAMP factor spyM18_1221 2 None None None 19745450 Common - hypothetical protein spyM18_0330 177 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 19745784 Common - hypothetical protein spyM18_0749 6 COG3747 COG3747, Phage terminase, small subunit DNA replication, recombination, and repair 19746144 Common - hypothetical protein spyM18_1163 42 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 19745384 Common - putative sugar transporter sugar binding lipoprotein spyM18_0234 51 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 19745356 Common - hypothetical protein spyM18_0195 73 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 19746239 Pathogen - putative structural phage protein spyM18_1268 1 None None None 19746119 Common - hypothetical protein spyM18_1133 3 None None None 19745647 Common - putative acetyl-CoA c-acetyltransferase spyM18_0590 170 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 19745600 Common - hypothetical protein spyM18_0518 68 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 19746734 Common - putative ABC transporter (ATP-binding protein) spyM18_1859 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 19745609 Pathogen - hypothetical protein spyM18_0545 1 None None None 19746078 Common - putative short chain dehydrogenase/reductase spyM18_1090 238 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 19746832 Common - putative salivaricin A ABC transporter spyM18_1981 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 19745655 Common - putative positive regulator spyM18_0599 7 None None None 19745531 Common - hypothetical protein spyM18_0427 19 COG3601 COG3601, Predicted membrane protein Function unknown 19746491 Common - hypothetical protein spyM18_1561 38 COG1288 COG1288, Predicted membrane protein Function unknown 19745791 Common - hypothetical protein spyM18_0756 10 None None None 19745975 Common ilvE branched-chain amino acid aminotransferase spyM18_0969 198 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 19746786 Common - x-prolyl-dipeptidyl aminopeptidase spyM18_1922 12 COG2936 COG2936, Predicted acyl esterases General function prediction only 19746565 Common - hypothetical protein spyM18_1655 3 None None None 19746910 Common scpA C5A peptidase precursor spyM18_2074 69 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 19745699 Common - prolipoprotein diacylglyceryl transferase spyM18_0654 208 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 19746069 Common - redox-sensing transcriptional repressor Rex spyM18_1081 56 COG2344 COG2344, AT-rich DNA-binding protein General function prediction only 19746475 Common - hypothetical protein spyM18_1543 1 None None None 19746271 Pathogen - hypothetical protein spyM18_1300 1 None None None 19745913 Common - putative ABC transporter (ATP-binding protein) spyM18_0897 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 19746763 Common ssb single-strand DNA-binding protein spyM18_1896 212 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 19745407 Common - hypothetical protein spyM18_0262 5 None None None 19746510 Common - hypothetical protein spyM18_1583 1 None None None 19746767 Common - hypothetical protein spyM18_1900 15 COG1476 COG1476, Predicted transcriptional regulators Transcription 19745230 Pathogen - hypothetical protein spyM18_0036 1 None None None 19745311 Common - putative acetyl-CoA acetyltransferase spyM18_0136 185 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 19745232 Common - hypothetical protein spyM18_0038 1 None None None 19745667 Common - hypothetical protein spyM18_0611 4 None None None 19746982 Common spxA transcriptional regulator Spx spyM18_2173 49 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 19745471 Pathogen - hypothetical protein spyM18_0355 1 None None None 19745837 Common - hypothetical protein spyM18_0808 40 COG2374 COG2374, Predicted extracellular nuclease General function prediction only 19746926 Pathogen - hypothetical protein spyM18_2102 1 None None None 19746437 Common - hypothetical protein spyM18_1500 18 COG3935 DnaD, Putative primosome component and related proteins DNA replication, recombination, and repair 19746138 Common - putative ABCtransporter (ATP-binding protein) spyM18_1157 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 19746248 Common - putative terminase, large subunit spyM18_1277 17 COG1783 XtmB, Phage terminase large subunit General function prediction only 19745271 Common adcR putative repressor protein spyM18_0092 8 COG1846 MarR, Transcriptional regulators Transcription 19745679 Common - putative immunity protein spyM18_0630 77 COG1619 LdcA, Uncharacterized proteins, homologs of microcin C7 resistance protein MccF Defense mechanisms 19746325 Common aroA 3-phosphoshikimate 1-carboxyvinyltransferase spyM18_1364 233 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 19746901 Pathogen - hypothetical protein spyM18_2065 1 None None None 19745670 Common - hypothetical protein spyM18_0615 3 None None None 19746625 Common - hypothetical protein spyM18_1731 32 COG2740 COG2740, Predicted nucleic-acid-binding protein implicated in transcription termination Transcription 19746714 Common dnaK molecular chaperone DnaK spyM18_1831 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 19745279 Common - putative DNA binding protein spyM18_0101 5 COG4699 COG4699, Uncharacterized protein conserved in bacteria Function unknown 19746720 Common - hypothetical protein spyM18_1837 13 COG2261 COG2261, Predicted membrane protein Function unknown 19746157 Common - putative phosphoglucomutase spyM18_1176 238 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 19746698 Common - hypothetical protein spyM18_1813 10 COG4687 COG4687, Uncharacterized protein conserved in bacteria Function unknown 19746406 Common - putative structural phage protein spyM18_1465 4 None None None 19746037 Common uvrC excinuclease ABC subunit C spyM18_1042 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 19746959 Common - hypothetical protein spyM18_2145 5 COG3758 COG3758, Uncharacterized protein conserved in bacteria Function unknown 19745339 Common ulaA ascorbate-specific PTS system enzyme IIC spyM18_0173 36 COG3037 SgaT, Uncharacterized protein conserved in bacteria Function unknown 19745766 Common - putative recombinase spyM18_0731 16 COG3723 RecT, Recombinational DNA repair protein (RecE pathway) DNA replication, recombination, and repair 19745692 Common - hypothetical protein spyM18_0643 9 COG3689 COG3689, Predicted membrane protein Function unknown 19745566 Pathogen - hypothetical protein spyM18_0476 1 COG5585 COG5585, NAD+--asparagine ADP-ribosyltransferase Signal transduction mechanisms 19745542 Common fhuC putative ferrichrome ABC transporter (ATP-binding protein) spyM18_0439 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 19745967 Common amiC amidase spyM18_0961 217 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 19745533 Common - hypothetical protein spyM18_0430 71 COG1242 COG1242, Predicted Fe-S oxidoreductase General function prediction only 19746375 Common - putative cation (K+) transport protein spyM18_1423 88 COG3158 Kup, K+ transporter Inorganic ion transport and metabolism 19745745 Common - acetoin reductase spyM18_0709 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 19745611 Pathogen - hypothetical protein spyM18_0548 1 None None None 19745822 Common tra truncated IS1239 transposase spyM18_0792 8 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 19746159 Common - putative sugar ABC transporter (permease protein) spyM18_1178 107 COG4603 COG4603, ABC-type uncharacterized transport system, permease component General function prediction only 19746956 Common - putative formiminotransferase cyclodeaminase spyM18_2142 22 COG3643 COG3643, Glutamate formiminotransferase Amino acid transport and metabolism 19747017 Common rplI 50S ribosomal protein L9 spyM18_2218 159 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 19745581 Common mtsB ATP-binding protein MtsB spyM18_0496 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 19746116 Common - putative CitG spyM18_1130 44 COG1767 CitG, Triphosphoribosyl-dephospho-CoA synthetase Coenzyme metabolism 19746354 Pathogen - hypothetical protein spyM18_1397 1 None None None 19746255 Common - hypothetical protein spyM18_1284 7 None None None 19746700 Common accA acetyl-CoA carboxylase subunit alpha spyM18_1815 177 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 19746455 Common folD putative bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase spyM18_1520 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 19745483 Common - hypothetical protein spyM18_0367 15 COG1403 McrA, Restriction endonuclease Defense mechanisms 19746381 Common recR recombination protein RecR spyM18_1432 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 19747041 Common - N-terminal fragment of an ABC transporter spyM18_2248 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 19746227 Common - hypothetical protein spyM18_1256 6 COG4722 COG4722, Phage-related protein Function unknown 19746600 Common glyQ glycyl-tRNA synthetase subunit alpha spyM18_1701 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 19745575 Common - hypothetical protein spyM18_0487 122 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 19745416 Common - putative aminotransferase spyM18_0276 239 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 19746056 Common potD putative spermidine / putrescine ABC transporter (periplasmic transport protein) spyM18_1067 137 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 19747037 Common - hypothetical protein spyM18_2243 11 COG4975 GlcU, Putative glucose uptake permease Carbohydrate transport and metabolism 19745301 Pathogen cbp putative collagen binding protein spyM18_0126 2 None None None 19746462 Common - putative mutator protein spyM18_1528 26 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 161484701 Common - acetyl-CoA carboxylase biotin carboxyl carrier protein subunit spyM18_1134 186 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 19746523 Common - hypothetical protein spyM18_1598 17 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 19745297 Common - hypothetical protein spyM18_0121 39 COG1428 COG1428, Deoxynucleoside kinases Nucleotide transport and metabolism 19746469 Common - hypothetical protein spyM18_1536 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 19745992 Common - hypothetical protein spyM18_0987 31 COG2384 COG2384, Predicted SAM-dependent methyltransferase General function prediction only 19746943 Common - hypothetical protein spyM18_2124 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 19745759 Pathogen - hypothetical protein spyM18_0724 1 None None None 19746315 Common - putative 16S pseudouridylate synthase spyM18_1351 207 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 19745284 Pathogen - hypothetical protein spyM18_0107 1 None None None 19746443 Common int putative integrase spyM18_1506 109 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 19746186 Common - putative transcriptional regulator spyM18_1208 19 COG1309 AcrR, Transcriptional regulator Transcription 19746260 Common - bacteriophage resistance protein spyM18_1289 2 None None None 19745411 Common uppP undecaprenyl pyrophosphate phosphatase spyM18_0268 201 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 19745513 Common - OxaA-like protein precursor spyM18_0404 11 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 19746249 Common - putative terminase, small subunit spyM18_1278 18 COG3728 XtmA, Phage terminase, small subunit DNA replication, recombination, and repair 19746603 Common nagA putative N-acetylglucosamine-6-phosphate deacetylase spyM18_1705 118 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 19745523 Common xerD site-specific tyrosine recombinase XerD-like protein spyM18_0415 4 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 19746211 Common - hypothetical protein spyM18_1236 16 COG0398 COG0398, Uncharacterized conserved protein Function unknown 19746081 Common - putative ABC transporter (binding protein) spyM18_1094 158 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 19745721 Common femA putative peptidoglycan branched peptide synthesis protein alanine adding enzyme spyM18_0682 12 COG2348 COG2348, Uncharacterized protein involved in methicillin resistance Defense mechanisms 19746242 Pathogen - hypothetical protein spyM18_1271 1 None None None 19745371 Common dut deoxyuridine 5'-triphosphate nucleotidohydrolase spyM18_0219 175 COG0756 Dut, dUTPase Nucleotide transport and metabolism 19745586 Common rplK 50S ribosomal protein L11 spyM18_0503 247 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 19745537 Common - putative manganese-dependent inorganic pyrophosphatase spyM18_0434 53 COG1227 PPX1, Inorganic pyrophosphatase/exopolyphosphatase Energy production and conversion 19745556 Common - hypothetical protein spyM18_0458 55 COG3142 CutC, Uncharacterized protein involved in copper resistance Inorganic ion transport and metabolism 19746104 Common - hypothetical protein spyM18_1117 115 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 19745763 Pathogen - hypothetical protein spyM18_0728 1 None None None 19746525 Common - putative sugar-binding transport protein spyM18_1601 141 COG4209 LplB, ABC-type polysaccharide transport system, permease component Carbohydrate transport and metabolism 19745595 Common phoH phosphate starvation-induced protein spyM18_0513 199 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 19746964 Common rpsB 30S ribosomal protein S2 spyM18_2151 222 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 19746107 Common rbgA ribosomal biogenesis GTPase spyM18_1121 166 COG1161 COG1161, Predicted GTPases General function prediction only 19746077 Common eutD phosphotransacetylase spyM18_1089 166 COG0280 Pta, Phosphotransacetylase Energy production and conversion 19746671 Common - hypothetical protein spyM18_1785 3 None None None 19746619 Common - putative cation-transporting ATP-ase spyM18_1724 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 19745572 Common - hypothetical protein spyM18_0484 162 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 19746136 Common guaA bifunctional GMP synthase/glutamine amidotransferase protein spyM18_1155 239 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 19746262 Common - hypothetical protein spyM18_1291 115 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 19746053 Common potA putative spermidine / putrescine ABC transporter spyM18_1064 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 19746693 Common int putative phage integrase spyM18_1808 32 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 19745285 Common - putative competence protein spyM18_0108 4 COG4940 ComGF, Competence protein ComGF Intracellular trafficking and secretion 19745570 Common - hypothetical protein spyM18_0482 5 None None None 19745519 Common - glutamate racemase spyM18_0411 189 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 19746374 Common - hypothetical protein spyM18_1420 71 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 19745554 Common - hypothetical protein spyM18_0456 209 COG0313 COG0313, Predicted methyltransferases General function prediction only 19746770 Common - putative DNA mismatch repair protein spyM18_1903 205 COG1193 COG1193, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 19747000 Common rpmF 50S ribosomal protein L32 spyM18_2196 55 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 19745561 Common - hypothetical protein spyM18_0467 14 COG3619 COG3619, Predicted membrane protein Function unknown 19746612 Common - galactose-6-phosphate isomerase subunit LacB spyM18_1716 128 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 19746379 Common - putative D-Ala-D-Ala adding enzyme spyM18_1429 208 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 19746372 Common - putative 1-acylglycerol-3-phosphate O-acyltransferase spyM18_1418 57 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 19746657 Pathogen - hypothetical protein spyM18_1770 1 None None None 19746752 Common - putative sucrose-6-phosphate hydrolase spyM18_1882 52 COG1621 SacC, Beta-fructosidases (levanase/invertase) Carbohydrate transport and metabolism 19746631 Common - putative ABC transporter (ATP-binding protein) spyM18_1737 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 19745435 Common - hypothetical protein spyM18_0311 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 19746707 Common - acyl-carrier-protein S-malonyltransferase spyM18_1822 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 19746527 Common - putative beta-glucosidase spyM18_1605 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 19745890 Common aroD 3-dehydroquinate dehydratase spyM18_0871 51 COG0710 AroD, 3-dehydroquinate dehydratase Amino acid transport and metabolism 19745697 Common - hypothetical protein spyM18_0651 2 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 19745260 Common rplO 50S ribosomal protein L15 spyM18_0072 216 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 19746994 Common - hypothetical protein spyM18_2185 63 COG1284 COG1284, Uncharacterized conserved protein Function unknown 19745579 Common - putative metal-dependent transcriptional regulator spyM18_0492 95 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 19745897 Common thiI thiamine biosynthesis protein ThiI spyM18_0879 94 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 19746606 Common - hypothetical protein spyM18_1709 42 COG1307 DegV, Uncharacterized protein conserved in bacteria Function unknown 19747014 Common rpsD 30S ribosomal protein S4 spyM18_2215 249 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 19746838 Common - tagatose 1,6-diphosphate aldolase spyM18_1987 26 COG3684 LacD, Tagatose-1,6-bisphosphate aldolase Carbohydrate transport and metabolism 19745994 Common - putative oxidoreductase spyM18_0989 95 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 19745735 Common - gluconate 5-dehydrogenase spyM18_0699 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 19746570 Common - putative penicillin-binding protein 1a spyM18_1661 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 19745668 Common - hypothetical protein spyM18_0612 4 None None None 19745613 Pathogen - hypothetical protein spyM18_0550 1 None None None 19746269 Pathogen - hypothetical protein spyM18_1298 1 None None None 19745547 Common clpP ATP-dependent Clp protease proteolytic subunit spyM18_0446 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 19746026 Common lepA GTP-binding protein (LepA) spyM18_1028 216 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 19746150 Common - putative glycine cleavage system H protein spyM18_1169 46 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 19745237 Common adhE putative Adh2 spyM18_0043 185 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 19745627 Common - putative sugar transferase spyM18_0568 192 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 19746208 Common - putative transcriptional regulator spyM18_1233 80 COG1725 COG1725, Predicted transcriptional regulators Transcription 19746474 Common murD UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase spyM18_1542 210 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 19745816 Common rpmE2 50S ribosomal protein L31 type B spyM18_0785 164 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 19746223 Pathogen - hypothetical protein spyM18_1251 1 None None None 19746554 Common priA primosome assembly protein PriA spyM18_1639 212 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 19745966 Common pyrE orotate phosphoribosyltransferase spyM18_0960 157 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 19746513 Common aroB putative 3-dehydroquinate synthase spyM18_1586 205 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 19746284 Common malR putative maltose operon transcriptional repressor spyM18_1313 128 COG1609 PurR, Transcriptional regulators Transcription 19746488 Common - asparagine synthetase AsnA spyM18_1556 31 COG2502 AsnA, Asparagine synthetase A Amino acid transport and metabolism 19745474 Pathogen - hypothetical protein spyM18_0358 1 None None None 19745993 Common - hypothetical protein spyM18_0988 142 COG0327 COG0327, Uncharacterized conserved protein Function unknown 19746133 Common ylmX hypothetical protein spyM18_1152 28 COG2739 COG2739, Uncharacterized protein conserved in bacteria Function unknown 19746533 Common - putative RNA methyltransferase spyM18_1615 197 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 19746398 Common - hypothetical protein spyM18_1456 6 COG4926 PblB, Phage-related protein Function unknown 19745998 Common mutT putative 7,8-dihydro-8-oxoguanine-triphosphatase spyM18_0994 23 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 19746234 Common - hypothetical protein spyM18_1263 4 None None None 19745800 Common - hypothetical protein spyM18_0765 48 COG5283 COG5283, Phage-related tail protein Function unknown 19745314 Common - hypothetical protein spyM18_0140 40 COG2964 COG2964, Uncharacterized protein conserved in bacteria Function unknown 19745403 Common rpsL 30S ribosomal protein S12 spyM18_0258 238 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 19746461 Common clp putative ATP-dependent protease spyM18_1527 219 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 19745807 Pathogen - hypothetical protein spyM18_0775 1 None None None 19745380 Common - hypothetical protein spyM18_0229 215 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 19745836 Common - putative ABC transporter (ATP-binding protein) spyM18_0807 8 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 19746031 Common - putative phosphotransferase system (PTS), enzyme II, component C spyM18_1036 36 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 19746012 Common acoC branched-chain alpha-keto acid dehydrogenase subunit E2 spyM18_1011 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 19746957 Common - putative serine cycle enzyme spyM18_2143 39 COG3404 COG3404, Methenyl tetrahydrofolate cyclohydrolase Amino acid transport and metabolism 19746425 Common - hypothetical protein spyM18_1488 70 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 19746782 Common - putative glycerol uptake facilitator spyM18_1917 132 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 19745746 Common dinG bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon spyM18_0710 151 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 19746145 Common cls putative cardiolipin synthetase spyM18_1164 146 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 19746090 Common - hypothetical protein spyM18_1103 239 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 19745933 Pathogen - hypothetical protein spyM18_0924 1 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 19746317 Common - hypothetical protein spyM18_1353 163 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 19746434 Pathogen - hypothetical protein spyM18_1497 1 None None None 19745204 Common - translation-associated GTPase spyM18_0004 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 19746989 Common - DNA mismatch repair protein spyM18_2180 202 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 19746768 Common trxA putative thioredoxin spyM18_1901 232 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 19745333 Common slo streptolysin O spyM18_0165 6 None None None 19746576 Common - hypothetical protein spyM18_1667 2 None None None 19745387 Common - hypothetical protein spyM18_0238 26 COG2731 EbgC, Beta-galactosidase, beta subunit Carbohydrate transport and metabolism 19746063 Common - hypothetical protein spyM18_1075 132 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 19746117 Common - putative transcriptional regulator spyM18_1131 106 COG1802 GntR, Transcriptional regulators Transcription 19746686 Pathogen - hypothetical protein spyM18_1800 1 None None None 19746900 Pathogen SMEZ mitogenic exotoxin Z precursor spyM18_2064 2 None None None 19745798 Pathogen - hypothetical protein spyM18_0763 1 None None None 19745251 Common rplN 50S ribosomal protein L14 spyM18_0062 247 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 19745243 Common rplW 50S ribosomal protein L23 spyM18_0052 187 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 19746851 Common - putative tRNA/rRNA methyltransferase spyM18_2005 216 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 19746196 Common - putative amino acid symporter spyM18_1219 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 19745645 Common - putative glycerol uptake facilitator spyM18_0588 134 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 19745817 Common - hypothetical protein spyM18_0787 85 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 19746060 Common - putative malic enzyme ((S)-malate:NAD+ oxidoreductase (decarboxylating)) spyM18_1072 202 COG0281 SfcA, Malic enzyme Energy production and conversion 19745528 Common - putative transposase spyM18_0421 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 19746650 Common - hypothetical protein spyM18_1762 6 COG4722 COG4722, Phage-related protein Function unknown 19745441 Common - putative sodium/dicarboxylate symporter spyM18_0318 154 COG3633 SstT, Na+/serine symporter Amino acid transport and metabolism 19746775 Common - putative exodeoxyribonuclease V (alpha subunit) spyM18_1908 139 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 19746275 Common - hypothetical protein spyM18_1304 3 None None None 19745308 Pathogen - hypothetical protein spyM18_0133 1 None None None 19745850 Common murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase spyM18_0821 212 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 19746747 Common - putative transposase spyM18_1875 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 19745262 Common adk adenylate kinase spyM18_0074 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 19746691 Pathogen - putative phage repressor protein spyM18_1805 1 None None None 19745349 Common - DNA polymerase I spyM18_0184 217 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 19746810 Common - hypothetical protein spyM18_1950 50 COG1461 COG1461, Predicted kinase related to dihydroxyacetone kinase General function prediction only 19746790 Common - putative transcriptional activator spyM18_1927 130 COG0789 SoxR, Predicted transcriptional regulators Transcription 19746580 Common mraY phospho-N-acetylmuramoyl-pentapeptide-transferase spyM18_1673 228 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 19746396 Common - hypothetical protein spyM18_1454 14 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 19745755 Pathogen - hypothetical protein spyM18_0719 1 None None None 19745830 Pathogen sagC SagC spyM18_0801 2 None None None 19745438 Common - putative ABC transporter (ATP-binding protein) spyM18_0315 249 COG1135 AbcC, ABC-type metal ion transport system, ATPase component Inorganic ion transport and metabolism 19745340 Common - hypothetical protein spyM18_0174 29 COG3414 SgaB, Phosphotransferase system, galactitol-specific IIB component Carbohydrate transport and metabolism 19746827 Common hsdM putative type I site-specific deoxyribonuclease spyM18_1976 162 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 19746712 Common - enoyl-CoA hydratase spyM18_1829 176 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 19746323 Common - putative PBP 5 synthesis repressor spyM18_1362 61 COG1316 LytR, Transcriptional regulator Transcription 19745394 Common ksgA dimethyladenosine transferase spyM18_0246 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 19746802 Common - hypothetical protein spyM18_1940 11 COG5503 COG5503, Uncharacterized conserved small protein Function unknown 19746813 Common - fructose-bisphosphate aldolase spyM18_1954 178 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 19745672 Common - hypothetical protein spyM18_0617 13 COG3668 ParE, Plasmid stabilization system protein General function prediction only 19746336 Common dnaX DNA polymerase III subunits gamma and tau spyM18_1376 248 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 19745443 Common - putative V-type Na+ -ATPase subunit J spyM18_0321 97 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 19745324 Common - V-type ATP synthase subunit B spyM18_0151 247 COG1156 NtpB, Archaeal/vacuolar-type H+-ATPase subunit B Energy production and conversion 19745226 Common purD phosphoribosylamine--glycine ligase spyM18_0032 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 19745497 Common - hypothetical protein spyM18_0383 3 COG4722 COG4722, Phage-related protein Function unknown 19746345 Common - His containing phosphocarrier protein spyM18_1385 101 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 19746504 Common - hypothetical protein spyM18_1575 13 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 19745648 Common - hypothetical protein spyM18_0592 39 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 19745786 Common - hypothetical protein spyM18_0751 46 COG4626 COG4626, Phage terminase-like protein, large subunit General function prediction only 19747029 Common - hypothetical protein spyM18_2232 11 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 19746665 Common - hypothetical protein spyM18_1779 8 None None None 19745968 Common - putative ABC transporter (binding protein) spyM18_0962 169 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 19746739 Common - putative ABC transporter (ATP-binding protein) spyM18_1865 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 19746869 Common - hypothetical protein spyM18_2026 94 COG0431 COG0431, Predicted flavoprotein General function prediction only 19747011 Common - hypothetical protein spyM18_2212 2 None None None 19746194 Common - hypothetical protein spyM18_1216 42 COG2261 COG2261, Predicted membrane protein Function unknown 19745957 Common rpiA ribose-5-phosphate isomerase A spyM18_0950 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 19745643 Common - putative dihydroxyacetone kinase spyM18_0586 76 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 19746470 Common ftsZ cell division protein FtsZ spyM18_1537 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 19746751 Common - putative sucrose-specific PTS permease, enzyme II spyM18_1881 60 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 19746758 Common pepP putative aminopeptidase spyM18_1889 244 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 19746745 Common acpS 4'-phosphopantetheinyl transferase spyM18_1872 130 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 19745214 Common - putative secreted protein spyM18_0020 12 COG3883 COG3883, Uncharacterized protein conserved in bacteria Function unknown 19746435 Pathogen - hypothetical protein spyM18_1498 1 None None None 19746218 Common - hypothetical protein spyM18_1243 14 None None None 19745278 Common ropC DNA-directed RNA polymerase subunit beta' spyM18_0100 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 19746411 Pathogen - hypothetical protein spyM18_1470 1 None None None 19745219 Common purC phosphoribosylaminoimidazole-succinocarboxamide synthase spyM18_0025 210 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 19745720 Common tpiA triosephosphate isomerase spyM18_0680 216 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 19745924 Common trxB putative thioredoxin reductase spyM18_0909 245 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 19746974 Common - hypothetical protein spyM18_2165 23 COG3981 COG3981, Predicted acetyltransferase General function prediction only 19746410 Pathogen - hypothetical protein spyM18_1469 1 None None None 19746024 Common - hypothetical protein spyM18_1024 94 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 19746296 Common glnH hypothetical protein spyM18_1327 190 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 19746099 Common gyrA DNA gyrase subunit A spyM18_1112 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 19745855 Common - hypothetical protein spyM18_0830 6 COG3272 COG3272, Uncharacterized conserved protein Function unknown 19746441 Common - putative repressor spyM18_1504 36 COG2932 COG2932, Predicted transcriptional regulator Transcription 19745291 Common - putative glutamyl-aminopeptidase spyM18_0115 78 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 19745868 Common - putative dTDP-4-keto-L-rhamnose reductase spyM18_0843 179 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 19746407 Pathogen - hypothetical protein spyM18_1466 1 None None None 19745464 Pathogen - hypothetical protein spyM18_0346 1 None None None 19747003 Common - putative cadmium efflux system accessory spyM18_2199 79 COG0640 ArsR, Predicted transcriptional regulators Transcription 19745549 Common tdk thymidylate kinase spyM18_0449 227 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 19746300 Pathogen - hypothetical protein spyM18_1332 1 None None None 19745378 Common - putative response regulator spyM18_0227 25 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 19746152 Common - putative trimethylamine dehydrogenase spyM18_1171 177 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 19746967 Common - putative dextran glucosidase spyM18_2154 162 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 19745540 Common fhuB putative ferrichrome ABC transporter (permease) spyM18_0437 186 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 19746547 Common - putative two-component response regulator spyM18_1630 216 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 19745840 Common - putative lipid kinase spyM18_0811 110 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 19745385 Common - putative sugar transport system (permease) spyM18_0236 140 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 19745657 Common - hypothetical protein spyM18_0601 7 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 19745602 Common tra IS1562 transposase spyM18_0536 48 COG3666 COG3666, Transposase and inactivated derivatives DNA replication, recombination, and repair 19746645 Pathogen - hypothetical protein spyM18_1754 1 None None None 19745633 Common - putative sugar transferase spyM18_0574 81 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 19746923 Common prsA foldase protein PrsA spyM18_2097 11 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 19745771 Pathogen - hypothetical protein spyM18_0736 1 None None None 19746358 Common - putative oxalateformate antiporter spyM18_1402 123 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 19745489 Pathogen - hypothetical protein spyM18_0373 1 None None None 19745883 Common - hypothetical protein spyM18_0864 1 None None None 19746021 Pathogen - hypothetical protein spyM18_1021 1 None None None 19745873 Common - putative glycosyltransferase spyM18_0852 132 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 19746909 Common - putative laminin adhesion spyM18_2073 178 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 19746728 Common - hypothetical protein spyM18_1850 109 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 19746035 Common - putative periplasmic-iron-binding protein spyM18_1040 77 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 19745552 Pathogen - hypothetical protein spyM18_0453 1 None None None 19746591 Common - putative translaldolase spyM18_1689 164 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 19745618 Common - hypothetical protein spyM18_0558 82 COG0433 COG0433, Predicted ATPase General function prediction only 19745712 Common - hypothetical protein spyM18_0669 11 None None None 19745599 Common era GTP-binding protein Era spyM18_0517 229 COG1159 Era, GTPase General function prediction only 19746092 Common glyA serine hydroxymethyltransferase spyM18_1105 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 19746912 Common mga positive regulatory protein Mga spyM18_2077 3 COG3711 BglG, Transcriptional antiterminator Transcription 19746185 Common - putative ABC transporter (ATP-binding protein) spyM18_1207 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 19746886 Common - putative transcriptional regulator spyM18_2047 111 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 19745427 Common - hypothetical protein spyM18_0301 43 COG2179 COG2179, Predicted hydrolase of the HAD superfamily General function prediction only 19746589 Pathogen - hypothetical protein spyM18_1686 1 None None None 19746309 Pathogen - hypothetical protein spyM18_1343 1 None None None 19746369 Common holA DNA polymerase III subunit delta spyM18_1415 46 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 19746610 Common - tagatose 1,6-diphosphate aldolase spyM18_1714 26 COG3684 LacD, Tagatose-1,6-bisphosphate aldolase Carbohydrate transport and metabolism 19745845 Common atpA F0F1 ATP synthase subunit alpha spyM18_0816 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 19746043 Common - hypothetical protein spyM18_1050 2 None None None 19746370 Common - putative competence protein spyM18_1416 127 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 19746552 Common - putative RNA-binding Sun protein spyM18_1637 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 19746388 Common - hypothetical protein spyM18_1444 1 None None None 19745899 Common tra putative transposase spyM18_0882 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 19746454 Common xseA exodeoxyribonuclease VII large subunit spyM18_1518 205 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 19746949 Common clp putative endopeptidase Clp ATP-binding chain C spyM18_2134 233 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 19746952 Common ahpC putative alkyl hydroperoxidase spyM18_2137 218 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 19746432 Common - putative recombinase spyM18_1495 24 COG3723 RecT, Recombinational DNA repair protein (RecE pathway) DNA replication, recombination, and repair 19746992 Common argS arginyl-tRNA synthetase spyM18_2183 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 19746929 Common - putative low temperature requirement C protein spyM18_2106 13 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 19746955 Common hutU urocanate hydratase spyM18_2141 97 COG2987 HutU, Urocanate hydratase Amino acid transport and metabolism 19745382 Common rpmH 50S ribosomal protein L34 spyM18_0232 6 None None None 19745577 Common pfs 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase spyM18_0490 89 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 19745584 Common ftsK hypothetical protein spyM18_0500 199 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 19745708 Common pgmA putative phosphoglycerate mutase spyM18_0665 145 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 19745834 Common - putative ABC transporter (ATP-binding protein) spyM18_0805 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 19745796 Pathogen - hypothetical protein spyM18_0761 1 None None None 19745987 Common - putative oxidoreductase spyM18_0982 238 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 19746065 Pathogen - hypothetical protein spyM18_1077 1 None None None 19745433 Common - hypothetical protein spyM18_0308 97 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 19746836 Common - putative PTS system, lactose-specific component IIBC spyM18_1985 37 COG1455 CelB, Phosphotransferase system cellobiose-specific component IIC Carbohydrate transport and metabolism 19746608 Common - hypothetical protein spyM18_1711 141 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 19746206 Common pfkA 6-phosphofructokinase spyM18_1231 157 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 19746464 Common ileS isoleucyl-tRNA synthetase spyM18_1531 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 19745245 Common rpsS 30S ribosomal protein S19 spyM18_0054 243 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 19746095 Common - putative ABC transporter (ATP-binding protein) spyM18_1108 247 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 19745996 Common cpsFP putative dTDP-4-keto-6-deoxyglucose-3,5-epimerase spyM18_0992 149 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 19745389 Common - putative acylneuraminate lyase spyM18_0240 230 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 19745545 Common upp uracil phosphoribosyltransferase spyM18_0443 165 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 19745674 Common - putative phage portal protein spyM18_0620 38 COG4695 COG4695, Phage-related protein Function unknown 19747026 Common - putative ABC transporter (ATP-binding protein) spyM18_2229 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 19747012 Common - hypothetical protein spyM18_2213 32 COG1511 COG1511, Predicted membrane protein Function unknown 19746051 Common folK pyrophosphokinase spyM18_1062 203 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 19746310 Common tra hypothetical protein spyM18_1344 25 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 19746638 Common - hypothetical protein spyM18_1745 1 None None None 19746147 Common lplA putative lipoate-protein ligase spyM18_1166 70 COG0095 LplA, Lipoate-protein ligase A Coenzyme metabolism 19746688 Common - hypothetical protein spyM18_1803 9 None None None 19746102 Pathogen - hypothetical protein spyM18_1115 1 None None None 19746039 Common - dipeptidase PepV spyM18_1044 153 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 19746141 Common pdxK pyridoxamine kinase spyM18_1160 21 COG2240 PdxK, Pyridoxal/pyridoxine/pyridoxamine kinase Coenzyme metabolism 19746673 Pathogen - hypothetical protein spyM18_1787 1 None None None 19745558 Common - putative 3'-exo-deoxyribonuclease spyM18_0461 196 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 19745593 Common - putative 42 kDa protein spyM18_0511 8 None None None 19745568 Pathogen - hypothetical protein spyM18_0479 1 None None None 19745761 Common - hypothetical protein spyM18_0726 18 COG3935 DnaD, Putative primosome component and related proteins DNA replication, recombination, and repair 19745949 Common mvaS2 HMG-CoA synthase spyM18_0942 57 COG3425 PksG, 3-hydroxy-3-methylglutaryl CoA synthase Lipid metabolism 19746377 Common prfC peptide chain release factor 3 spyM18_1425 249 COG4108 PrfC, Peptide chain release factor RF-3 Translation, ribosomal structure and biogenesis 19746617 Common - putative lactose phosphotransferase system repressor protein spyM18_1722 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 19745335 Pathogen - hypothetical protein spyM18_0167 1 None None None 19746695 Common - mannose-specific phosphotransferase system component IIAB spyM18_1810 81 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 19745421 Common oppA oligopeptide permease spyM18_0281 137 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 19746075 Common ppnK inorganic polyphosphate/ATP-NAD kinase spyM18_1087 238 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 19746422 Pathogen - hypothetical protein spyM18_1485 1 None None None 19746563 Common - N-terminal fragment of a hypotheitcal protein spyM18_1651 39 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 19746258 Common - hypothetical protein spyM18_1287 6 None None None 19746585 Common proA gamma-glutamyl phosphate reductase spyM18_1679 193 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 19746615 Common - putative PTS system, enzyme IIB component spyM18_1720 4 COG3414 SgaB, Phosphotransferase system, galactitol-specific IIB component Carbohydrate transport and metabolism 19746319 Common - hypothetical protein spyM18_1357 37 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 19746174 Common pstS putative phosphate ABC transporter, periplasmic phosphate-binding protein spyM18_1194 155 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 19745931 Common alyS putative peptidoglycan hydrolase spyM18_0916 58 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 19746213 Pathogen - putative exotoxin precursor (SpeL) spyM18_1238 2 None None None 19745459 Pathogen - hypothetical protein spyM18_0341 1 None None None 19746245 Pathogen - hypothetical protein spyM18_1274 1 None None None 19746236 Pathogen - hypothetical protein spyM18_1265 2 None None None 19746429 Pathogen - hypothetical protein spyM18_1492 1 None None None 19747022 Common - putative L-serine dehydratase beta subunit spyM18_2224 145 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 19745281 Common - putative competence protein, ABC transporter subunit spyM18_0103 108 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 19745455 Common int putative integrase spyM18_0336 35 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 19745316 Common - putative regulatory protein spyM18_0142 26 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 19745937 Common - putative ABC transporter (ATP-binding protein) spyM18_0928 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 19747034 Common hasC UDP-glucose pyrophosphorylase spyM18_2240 232 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 19746624 Common - hypothetical protein spyM18_1730 22 COG1358 RPL8A, Ribosomal protein HS6-type (S12/L30/L7a) Translation, ribosomal structure and biogenesis 19745819 Common cm hypothetical protein spyM18_0789 20 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 19745399 Common - putative CMP-binding factor spyM18_0251 46 COG3481 COG3481, Predicted HD-superfamily hydrolase General function prediction only 19746169 Common phoU putative phosphate uptake regulatory protein spyM18_1189 199 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 19746062 Common aphA acid phosphatase/phosphotransferase spyM18_1074 12 COG3700 AphA, Acid phosphatase (class B) General function prediction only 19746575 Common trxB thioredoxin reductase spyM18_1666 248 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 19746131 Common - putative repressor protein spyM18_1150 12 COG2932 COG2932, Predicted transcriptional regulator Transcription 19745680 Pathogen - hypothetical protein spyM18_0631 1 None None None 19746289 Common - putative esterase spyM18_1320 66 COG0657 Aes, Esterase/lipase Lipid metabolism 19745400 Common - putative transposase spyM18_0253 4 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 19745276 Common pbp putative penicillin-binding protein 1b spyM18_0098 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 19745888 Common - hypothetical protein spyM18_0869 56 COG1368 MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily Cell envelope biogenesis, outer membrane 19746485 Common - hypothetical protein spyM18_1553 41 COG3480 SdrC, Predicted secreted protein containing a PDZ domain Signal transduction mechanisms 19745743 Common fts putative cell-division protein spyM18_0707 121 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 19745235 Common - hypothetical protein spyM18_0041 25 COG4642 COG4642, Uncharacterized protein conserved in bacteria Function unknown 19745805 Pathogen - hypothetical protein spyM18_0773 1 None None None 19745658 Common - hypothetical protein spyM18_0602 44 COG1478 COG1478, Uncharacterized conserved protein Function unknown 19747042 Common - hypothetical protein spyM18_2250 11 COG4485 COG4485, Predicted membrane protein Function unknown 19746535 Common - hypothetical protein spyM18_1617 14 COG3557 COG3557, Uncharacterized domain/protein associated with RNAses G and E Translation, ribosomal structure and biogenesis 19745343 Common - putative L-xylulose 5-phosphate 3-epimerase spyM18_0177 34 COG3623 SgaU, Putative L-xylulose-5-phosphate 3-epimerase Carbohydrate transport and metabolism 19746115 Common - putative methylmalonyl-CoA decarboxylase, beta-subunit spyM18_1129 57 COG1883 OadB, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit Energy production and conversion 19745964 Common - hypothetical protein spyM18_0958 1 None None None 19745651 Common vicK two-component sensor histidine kinase spyM18_0595 222 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 19745969 Common - putative ABC transporter (permease) spyM18_0963 172 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 19745290 Common - pyrroline-5-carboxylate reductase spyM18_0113 213 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 19746980 Common - Holliday junction resolvase-like protein spyM18_2171 183 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 19745351 Common - ferric transport regulator protein spyM18_0186 191 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 19746780 Common - putative C3-degrading proteinase spyM18_1914 3 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 19746282 Common glgP putative glycogen phosphorylase spyM18_1311 145 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 19746515 Common - hypothetical protein spyM18_1589 36 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 19746705 Common - 3-oxoacyl-(acyl carrier protein) synthase II spyM18_1820 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 19746815 Common pyrG CTP synthetase spyM18_1959 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 19745971 Common pyrC dihydroorotase spyM18_0965 213 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 19745250 Common rpsQ 30S ribosomal protein S17 spyM18_0061 221 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 19746288 Pathogen - hypothetical protein spyM18_1319 1 None None None 19746439 Common - putative excisionase spyM18_1502 3 None None None 19745977 Common rpsA 30S ribosomal protein S1 spyM18_0971 226 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 19745373 Common - hypothetical protein spyM18_0221 58 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 19746423 Pathogen - hypothetical protein spyM18_1486 1 None None None 19746820 Common - hypothetical protein spyM18_1964 14 COG4720 COG4720, Predicted membrane protein Function unknown 19745392 Common - hypothetical protein spyM18_0243 239 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 19745499 Common hylP phage hyaluronidase spyM18_0385 2 None None None 19746129 Pathogen - hypothetical protein spyM18_1144 1 None None None 19745490 Pathogen - hypothetical protein spyM18_0374 1 None None None 19745514 Common - putative acylphosphatase spyM18_0405 33 COG1254 AcyP, Acylphosphatases Energy production and conversion 19746506 Pathogen - hypothetical protein spyM18_1578 1 None None None 19746343 Common gapN putative NADP-dependent glyceraldehyde-3-phosphate dehydrogenase spyM18_1383 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 19745615 Common - putative positive transcriptional regulator spyM18_0554 7 None None None 19745955 Pathogen - hypothetical protein spyM18_0948 1 None None None 19746804 Common glnA putative glutamine synthetase spyM18_1942 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 19746737 Common - putative ABC transporter (ATP-binding protein) spyM18_1862 241 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 19746643 Pathogen - hypothetical protein spyM18_1752 1 None None None 19745263 Common infA translation initiation factor IF-1 spyM18_0075 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 19745688 Common - putative drug resistance protein spyM18_0639 194 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 19745445 Common lemA putative cytoplasmic membrane protein spyM18_0324 131 COG1704 LemA, Uncharacterized conserved protein Function unknown 19745901 Common - hypothetical protein spyM18_0884 13 COG2868 COG2868, Predicted ribosomal protein Translation, ribosomal structure and biogenesis 19746490 Common - hypothetical protein spyM18_1560 141 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 19745908 Common pyrP putative uracil permease spyM18_0891 121 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 19746797 Common - putative transcriptional regulator spyM18_1935 69 COG2188 PhnF, Transcriptional regulators Transcription 19745950 Common thyA thymidylate synthase spyM18_0943 135 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 19746903 Common dppB transmembrane transport protein spyM18_2067 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 19745212 Common ftsH putative cell division protein spyM18_0014 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 19746561 Common atoA putative Acetyl-CoA:acetoacetyl-CoA transferase b subunit spyM18_1647 100 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 19745360 Pathogen speG exotoxin G precursor spyM18_0201 2 None None None 19746413 Common - hypothetical protein spyM18_1472 2 None None None 19745597 Common - hypothetical protein spyM18_0515 183 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 19746800 Common rimI putative ribosomal-protein-alanine acetyltransferase spyM18_1938 116 COG0456 RimI, Acetyltransferases General function prediction only 19745296 Common ssb single-strand DNA-binding protein spyM18_0120 183 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 19745660 Common - S-adenosylmethionine synthetase spyM18_0604 43 COG1812 MetK, Archaeal S-adenosylmethionine synthetase Amino acid transport and metabolism 19745288 Common - acetate kinase spyM18_0111 162 COG0282 ackA, Acetate kinase Energy production and conversion 19745727 Common pacL putative calcium-transporting ATPase spyM18_0689 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 19745788 Pathogen - hypothetical protein spyM18_0753 1 None None None 19746582 Common - putative cell division protein spyM18_1675 6 COG4839 FtsL, Protein required for the initiation of cell division Cell division and chromosome partitioning 19747045 Common - putative serine protease spyM18_2256 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 19746215 Pathogen - hypothetical protein spyM18_1240 1 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 19746896 Common - recombination factor protein RarA spyM18_2058 245 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 19745321 Common - putative V-type Na+ -ATPase subunit C spyM18_0147 7 COG1527 NtpC, Archaeal/vacuolar-type H+-ATPase subunit C Energy production and conversion 19746273 Pathogen - hypothetical protein spyM18_1302 1 None None None 19745436 Common - hypothetical protein spyM18_0312 107 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 19745752 Common int putative integrase; bacteriophage 370.1 spyM18_0716 142 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 19746112 Common - oxaloacetate decarboxylase spyM18_1126 175 COG5016 COG5016, Pyruvate/oxaloacetate carboxyltransferase Energy production and conversion 19746893 Common - putative amidase spyM18_2055 193 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 19745305 Pathogen - hypothetical protein spyM18_0130 1 None None None 19745810 Pathogen speC exotoxin C precursor spyM18_0778 2 None None None 19746845 Common rpsI 30S ribosomal protein S9 spyM18_1999 219 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 161484698 Common - transketolase spyM18_1687 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 19746394 Pathogen - hypothetical protein spyM18_1452 1 None None None 19745750 Common - hypothetical protein spyM18_0714 91 COG0391 COG0391, Uncharacterized conserved protein Function unknown 19746386 Pathogen - hypothetical protein spyM18_1442 1 None None None 19745635 Common thrS threonyl-tRNA synthetase spyM18_0576 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 19746161 Common - putative lipoprotein spyM18_1180 96 COG1744 Med, Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein General function prediction only 19746667 Common - hypothetical protein spyM18_1781 24 COG4933 COG4933, Uncharacterized conserved protein Function unknown 19745773 Pathogen - hypothetical protein spyM18_0738 1 None None None 19746863 Common - hypothetical protein spyM18_2018 44 COG3711 BglG, Transcriptional antiterminator Transcription 19746932 Common pflD putative pyruvate formate-lyase 2 spyM18_2110 59 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 19745980 Common - hypothetical protein spyM18_0974 14 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 19745504 Pathogen - putative holin spyM18_0390 1 COG5546 COG5546, Small integral membrane protein Function unknown 19746873 Common - hypothetical protein spyM18_2031 205 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 19746018 Common - hypothetical protein spyM18_1018 67 COG1624 COG1624, Uncharacterized conserved protein Function unknown 19745714 Common bsaA putative glutathione peroxidase spyM18_0672 114 COG0386 BtuE, Glutathione peroxidase Posttranslational modification, protein turnover, chaperones 19745604 Common - putative histidine kinase spyM18_0539 13 COG2972 COG2972, Predicted signal transduction protein with a C-terminal ATPase domain Signal transduction mechanisms 19745229 Common - hypothetical protein spyM18_0035 2 None None None 19745989 Common apt adenine phosphoribosyltransferase spyM18_0984 183 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 19746042 Common rplJ 50S ribosomal protein L10 spyM18_1048 215 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 19745501 Pathogen - hypothetical protein spyM18_0387 1 None None None 19745881 Common - putative pore-forming peptide spyM18_0862 2 None None None 19746448 Pathogen - hypothetical protein spyM18_1512 1 None None None 19746290 Common - putative extramembranal protein spyM18_1321 12 COG3966 DltD, Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) Cell envelope biogenesis, outer membrane 19746049 Common folP dihyropteroate synthase spyM18_1060 219 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 19746495 Common - hypothetical protein spyM18_1565 120 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 19746071 Common nifS putative iron-sulfur cofactor synthesis protein spyM18_1083 240 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 19745425 Common oppF oligopeptide permease spyM18_0285 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 19746960 Common - putative cationic amino acid transporter spyM18_2146 187 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 19745866 Common rpoD RNA polymerase sigma factor RpoD spyM18_0841 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 19746125 Common citF putative citrate lyase, alpha subunit spyM18_1140 28 COG3051 CitF, Citrate lyase, alpha subunit Energy production and conversion 19746592 Common - putative transcriptional regulatory protein spyM18_1692 4 COG3711 BglG, Transcriptional antiterminator Transcription 19746094 Common - hypothetical protein spyM18_1107 8 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 19746727 Common - aminotransferase AlaT spyM18_1849 239 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 19745917 Common - hypothetical protein spyM18_0901 14 COG1837 COG1837, Predicted RNA-binding protein (contains KH domain) General function prediction only 19745487 Common - hypothetical protein spyM18_0371 160 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 19746636 Common - hypothetical protein spyM18_1743 191 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 19745740 Common - hypothetical protein spyM18_0704 138 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 19746367 Pathogen - hypothetical protein spyM18_1413 1 None None None 19746360 Common - putative transcription factor spyM18_1405 13 COG4469 CoiA, Competence protein General function prediction only 19745719 Common tuf elongation factor Tu spyM18_0678 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 19746776 Pathogen - hypothetical protein spyM18_1909 1 None None None 19745825 Common - septation ring formation regulator EzrA spyM18_0796 31 COG4477 EzrA, Negative regulator of septation ring formation Cell division and chromosome partitioning 19746244 Pathogen - hypothetical protein spyM18_1273 1 None None None 19746183 Common - hypothetical protein spyM18_1203 7 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 19746829 Common - putative response regulator of salavaricin regulon spyM18_1978 162 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 19745820 Common - putative transmembrane protein spyM18_0790 32 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 19745944 Common mvaK1 mevalonate kinase spyM18_0937 28 COG1577 ERG12, Mevalonate kinase Lipid metabolism 19746302 Common ptcB putative PTS system enzyme II spyM18_1334 29 COG1440 CelA, Phosphotransferase system cellobiose-specific component IIB Carbohydrate transport and metabolism 19746070 Common - hypothetical protein spyM18_1082 7 None None None 19746807 Common pgk phosphoglycerate kinase spyM18_1946 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 19746545 Common - hypothetical protein spyM18_1628 217 COG1098 VacB, Predicted RNA binding protein (contains ribosomal protein S1 domain) Translation, ribosomal structure and biogenesis 19746409 Pathogen - hypothetical protein spyM18_1468 1 None None None 19746134 Common - putative transcription regulator spyM18_1153 130 COG2188 PhnF, Transcriptional regulators Transcription 19745686 Common - hypothetical protein spyM18_0637 123 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 19745466 Common - hypothetical protein spyM18_0349 12 None None None 19745757 Pathogen - putative cro protein spyM18_0722 2 COG1476 COG1476, Predicted transcriptional regulators Transcription 19746675 Pathogen - hypothetical protein spyM18_1789 1 None None None 19746321 Pathogen - hypothetical protein spyM18_1359 1 None None None 19745342 Common ulaD 3-keto-L-gulonate-6-phosphate decarboxylase spyM18_0176 50 COG0269 SgbH, 3-hexulose-6-phosphate synthase and related proteins Carbohydrate transport and metabolism 19745706 Common lysS lysyl-tRNA synthetase spyM18_0663 248 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 19746754 Common nusB transcription antitermination protein NusB spyM18_1884 93 COG0781 NusB, Transcription termination factor Transcription 19745804 Common - hypothetical protein spyM18_0771 3 None None None 19746985 Common tag putative 3-methyl-adenine DNA glycosylase I spyM18_2176 132 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 19745408 Common - putative amino acid ABC transporter (ATP-binding protein) spyM18_0263 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 19745274 Common - putative histidine triad (HIT) protein spyM18_0095 40 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 19746312 Common - nicotinate-nucleotide pyrophosphorylase spyM18_1346 204 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 19745353 Common tgt queuine tRNA-ribosyltransferase spyM18_0189 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 19745803 Common hylP hyaluronidase - phage associated spyM18_0770 2 None None None 19745470 Common - hypothetical protein spyM18_0353 5 None None None 19745398 Common - hypothetical protein spyM18_0250 128 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 19745676 Common - hypothetical protein spyM18_0622 17 COG3177 COG3177, Uncharacterized conserved protein Function unknown 19747032 Common hasA hyaluronate synthase A spyM18_2236 105 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 19746835 Common - putative phospho-beta-D-galactosidase spyM18_1984 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 19745973 Common parE DNA topoisomerase IV subunit B spyM18_0967 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 19746787 Pathogen - hypothetical protein spyM18_1923 2 None None None 19746516 Common - hypothetical protein spyM18_1590 141 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 19746016 Common - hypothetical protein spyM18_1016 57 COG3442 COG3442, Predicted glutamine amidotransferase General function prediction only 19746682 Common - hypothetical protein spyM18_1796 13 None None None 19746068 Common - hypothetical protein spyM18_1080 120 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 19746788 Common - putative repressor spyM18_1925 5 COG1476 COG1476, Predicted transcriptional regulators Transcription 19745240 Common rpsJ 30S ribosomal protein S10 spyM18_0049 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 19746536 Pathogen - hypothetical protein spyM18_1618 1 None None None 19746027 Common - methionine sulfoxide reductase B spyM18_1032 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 19746566 Common - hypothetical protein spyM18_1656 133 COG0116 COG0116, Predicted N6-adenine-specific DNA methylase DNA replication, recombination, and repair 19745453 Common engA GTP-binding protein EngA spyM18_0334 231 COG1160 COG1160, Predicted GTPases General function prediction only 19746280 Common int integrase spyM18_1309 166 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 19745851 Pathogen epuA hypothetical protein spyM18_0822 1 None None None 19745935 Common - hypothetical protein spyM18_0926 48 COG1307 DegV, Uncharacterized protein conserved in bacteria Function unknown 19745525 Common scpB segregation and condensation protein B spyM18_0417 153 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 19745978 Pathogen - hypothetical protein spyM18_0972 1 None None None 19745687 Common - putative signal recognition particle (docking protein) spyM18_0638 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 19746760 Common - putative divalent cation transport spyM18_1893 78 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 19746748 Common manA putative mannose-6-phosphate isomerase spyM18_1876 51 COG1482 ManA, Phosphomannose isomerase Carbohydrate transport and metabolism 19746251 Pathogen - hypothetical protein spyM18_1280 1 None None None 19746764 Common rpsF 30S ribosomal protein S6 spyM18_1897 188 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 19745346 Common - putative L-ascorbate 6-phosphate lactonase spyM18_0180 21 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 19745383 Common - N-acetylmannosamine-6-phosphate 2-epimerase spyM18_0233 43 COG3010 NanE, Putative N-acetylmannosamine-6-phosphate epimerase Carbohydrate transport and metabolism 19746595 Common glpA putative alpha-glycerophosphate oxidase spyM18_1695 146 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 19746858 Common - hypothetical protein spyM18_2013 2 None None None 19746969 Common - putative transcriptional regulator spyM18_2157 102 COG2188 PhnF, Transcriptional regulators Transcription 19746529 Common - putative transcription regulator spyM18_1609 149 COG1609 PurR, Transcriptional regulators Transcription 19746238 Common - hypothetical protein spyM18_1267 4 None None None 19745646 Pathogen - hypothetical protein spyM18_0589 1 None None None 19746438 Pathogen - hypothetical protein spyM18_1501 1 None None None 19746792 Common - hypothetical protein spyM18_1929 2 None None None 19746030 Common - putative phosphotransferase system (PTS), enzyme II component B spyM18_1035 39 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 19745208 Common divIC putative cell division protein spyM18_0009 6 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 19746247 Common - phage protein spyM18_1276 11 None None None 19745473 Common - hypothetical protein spyM18_0357 2 None None None 19746569 Common recU Holliday junction-specific endonuclease spyM18_1660 17 COG3331 PrfA, Penicillin-binding protein-related factor A, putative recombinase General function prediction only 19746825 Common hsdR putative type I site-specific deoxyribonuclease spyM18_1974 139 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 19746927 Common - Rgg spyM18_2103 6 None None None 19746020 Common - putative phospho-sugar mutase spyM18_1020 243 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 19745606 Common - N-terminal fragment of BlpB spyM18_0542 5 None None None 19745205 Common pth peptidyl-tRNA hydrolase spyM18_0005 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 19746668 Pathogen - hypothetical protein spyM18_1782 1 None None None 19745422 Common oppB oligopeptide permease spyM18_0282 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 19745247 Common rpsC 30S ribosomal protein S3 spyM18_0057 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 19746128 Common citC putative citrate lyase synthetase spyM18_1143 25 COG3053 CitC, Citrate lyase synthetase Energy production and conversion 19745794 Pathogen - hypothetical protein spyM18_0759 1 None None None 19746947 Common groES co-chaperonin GroES spyM18_2131 171 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 19746192 Pathogen - hypothetical protein spyM18_1214 1 COG5547 COG5547, Small integral membrane protein Function unknown 19746113 Pathogen - hypothetical protein spyM18_1127 1 None None None 19746189 Common - hypothetical protein spyM18_1211 35 COG1302 COG1302, Uncharacterized protein conserved in bacteria Function unknown 19745264 Common rpmJ 50S ribosomal protein L36 spyM18_0076 139 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 19746427 Pathogen - hypothetical protein spyM18_1490 1 None None None 19745811 Common MF2 MF2 spyM18_0779 7 None None None 19745559 Common - putative lactate oxidase spyM18_0462 112 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 19746613 Common - galactose-6-phosphate isomerase subunit LacA spyM18_1717 121 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 19745767 Pathogen - hypothetical protein spyM18_0732 1 None None None 19746842 Common - putative lactose phosphotransferase system repressor protein spyM18_1993 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 19746100 Common - hypothetical protein spyM18_1113 16 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 19746378 Common - hypothetical protein spyM18_1428 3 COG5522 COG5522, Predicted integral membrane protein Function unknown 19746353 Common - putative transcriptional regulator spyM18_1396 50 COG1476 COG1476, Predicted transcriptional regulators Transcription 19746573 Common - nicotinate phosphoribosyltransferase spyM18_1664 116 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 19746084 Common - putative purine permease spyM18_1097 127 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 19745414 Common - putative ABC transporter (ATP-binding protein) spyM18_0273 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 19746549 Common - hypothetical protein spyM18_1632 9 COG4758 COG4758, Predicted membrane protein Function unknown 19745930 Common acmA putative peptidoglycan hydrolase spyM18_0915 18 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 19746154 Common dfpB phosphopantothenate--cysteine ligase spyM18_1173 194 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 19745303 Pathogen - hypothetical protein spyM18_0128 1 None None None 19745543 Common murE UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase spyM18_0440 212 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 19745705 Common - hypothetical protein spyM18_0661 11 COG4443 COG4443, Uncharacterized protein conserved in bacteria Function unknown 19745590 Common - hypothetical protein spyM18_0507 42 COG2996 COG2996, Uncharacterized protein conserved in bacteria Function unknown 19746265 Pathogen - hypothetical protein spyM18_1294 1 None None None 19746468 Common - hypothetical protein spyM18_1535 30 COG1799 COG1799, Uncharacterized protein conserved in bacteria Function unknown 19746176 Common - putative myo-inositol-1(or 4)-monophosphatase spyM18_1196 180 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 19746458 Common - putative amino acid ABC transporter (ATP-binding protein) spyM18_1524 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 19746522 Common - hypothetical protein spyM18_1597 4 COG5578 COG5578, Predicted integral membrane protein Function unknown 19746226 Common - hypothetical protein spyM18_1255 10 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 19747044 Common - hypothetical protein spyM18_2255 162 COG1576 COG1576, Uncharacterized conserved protein Function unknown 19746940 Common - penicillin-binding protein 2a spyM18_2120 205 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 19745257 Common rplR 50S ribosomal protein L18 spyM18_0068 216 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 19746057 Common - putative two-component response regulator spyM18_1068 45 COG4565 CitB, Response regulator of citrate/malate metabolism Transcription / Signal transduction mechanisms 19746444 Common - hypothetical protein spyM18_1508 3 None None None 19745338 Common leuS leucyl-tRNA synthetase spyM18_0171 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 19746697 Common - putative mannose-specific phosphotransferase system component IID spyM18_1812 41 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 19746148 Common - hypothetical protein spyM18_1167 16 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 19746420 Pathogen - hypothetical protein spyM18_1482 1 None None None 19746440 Common - putative Cro-like repressor spyM18_1503 8 COG1476 COG1476, Predicted transcriptional regulators Transcription 19745457 Pathogen - orf122 phage protein spyM18_0339 1 None None None 19746108 Common rnhB ribonuclease HII spyM18_1122 232 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 19746944 Common - hypothetical protein spyM18_2125 5 COG4640 COG4640, Predicted membrane protein Function unknown 19746038 Common - putative NADH dehydrogenase spyM18_1043 78 COG0778 NfnB, Nitroreductase Energy production and conversion 19746459 Common - putative amino acid ABC transporter (permease protein) spyM18_1525 174 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 19745361 Pathogen - hypothetical protein spyM18_0202 1 None None None 19745693 Common - hypothetical protein spyM18_0644 95 COG0701 COG0701, Predicted permeases General function prediction only 19745419 Common - putative DD-carboxypeptidase spyM18_0279 139 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 19745582 Common mtsC integral membrane protein MtsC spyM18_0498 186 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 19746478 Common - glucose kinase spyM18_1546 161 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 19746219 Common - hypothetical protein spyM18_1244 67 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 19746229 Common - putative minor tail protein spyM18_1258 6 None None None 19745694 Pathogen - hypothetical protein spyM18_0646 1 None None None 19746098 Common ldh L-lactate dehydrogenase spyM18_1111 168 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 19746655 Pathogen - putative minor capsid protein spyM18_1767 1 None None None 19746452 Common ispA putative geranyltranstransferase spyM18_1516 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 19747018 Common - hypothetical protein spyM18_2219 39 COG3887 COG3887, Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain Signal transduction mechanisms 19745534 Common - hypothetical protein spyM18_0431 29 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 19745484 Pathogen - hypothetical protein spyM18_0368 3 None None None 19745431 Common - hypothetical protein spyM18_0305 43 COG1713 COG1713, Predicted HD superfamily hydrolase involved in NAD metabolism Coenzyme metabolism 19746628 Common trmB tRNA (guanine-N(7))-methyltransferase spyM18_1734 177 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 19746164 Common coaA pantothenate kinase spyM18_1183 74 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 19745895 Pathogen - hypothetical protein spyM18_0877 1 None None None 19746970 Common - hypothetical protein spyM18_2160 152 COG1733 COG1733, Predicted transcriptional regulators Transcription 19745567 Pathogen - hypothetical protein spyM18_0477 1 None None None 19745988 Common recJ putative single-strand DNA-specific exonuclease spyM18_0983 194 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 19746305 Common bglA putative beta-glucosidase spyM18_1338 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 19746203 Common glmS D-fructose-6-phosphate amidotransferase spyM18_1228 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 19745221 Common purF amidophosphoribosyltransferase spyM18_0027 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 19746291 Common - D-alanine--poly(phosphoribitol) ligase subunit 2 spyM18_1322 12 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 19746298 Pathogen - hypothetical protein spyM18_1329 1 None None None 19746998 Common hisS histidyl-tRNA synthetase spyM18_2189 248 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 19746096 Common - putative ABC transporter (ATP-binding protein) spyM18_1109 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 19746181 Common - hypothetical protein spyM18_1201 40 COG4487 COG4487, Uncharacterized protein conserved in bacteria Function unknown 19746987 Common - putative integral membrane protein spyM18_2178 62 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 19745482 Pathogen - hypothetical protein spyM18_0366 1 None None None 19745927 Common fruR putative transcriptional repressor spyM18_0912 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 19746677 Pathogen - hypothetical protein spyM18_1791 2 None None None 19745742 Common ftsE putative cell-division ATP-binding protein spyM18_0706 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 19747031 Common - hypothetical protein spyM18_2234 66 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 19745468 Pathogen - hypothetical protein spyM18_0351 1 None None None 19746963 Common - putative regulatory protein spyM18_2149 47 COG3899 COG3899, Predicted ATPase General function prediction only 19745961 Common deoD putative purine nucleoside phosphorylase spyM18_0955 93 COG0813 DeoD, Purine-nucleoside phosphorylase Nucleotide transport and metabolism 19746542 Common - putative late competence protein spyM18_1625 37 COG4098 comFA, Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) DNA replication, recombination, and repair 19745463 Pathogen - hypothetical protein spyM18_0345 1 None None None 161484700 Common obgE GTPase ObgE spyM18_1342 249 COG0536 Obg, Predicted GTPase General function prediction only 19746328 Common - hypothetical protein spyM18_1367 56 COG4109 COG4109, Predicted transcriptional regulator containing CBS domains Transcription 19745947 Common - isopentenyl pyrophosphate isomerase spyM18_0940 83 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 19746718 Common - putative D,D-carboxypeptidase spyM18_1835 36 COG1876 VanY, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 19745872 Common - ABC transporter (ATP-binding protein) spyM18_0849 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 19745255 Common rpsH 30S ribosomal protein S8 spyM18_0066 248 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 19746621 Common - putative esterase spyM18_1727 53 COG0657 Aes, Esterase/lipase Lipid metabolism 19746171 Common pstB2 putative phosphate ABC transporter (ATP-binding protein) spyM18_1191 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 19745506 Pathogen speA exotoxin type A precursor spyM18_0393 2 None None None 19745864 Common mscL putative large conductance mechanosensitive channel spyM18_0839 30 COG1970 MscL, Large-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 19745637 Common - putative ABC transporter (ATP-binding protein) spyM18_0579 249 COG4586 COG4586, ABC-type uncharacterized transport system, ATPase component General function prediction only 19745357 Common - hypothetical protein spyM18_0196 212 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 19746860 Common - transaldolase spyM18_2015 92 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 19745716 Common pepC phosphoenolpyruvate carboxylase spyM18_0675 116 COG2352 Ppc, Phosphoenolpyruvate carboxylase Energy production and conversion 19745877 Common - hypothetical protein spyM18_0858 5 None None None 19745919 Common - hypothetical protein spyM18_0904 19 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 19745982 Pathogen - hypothetical protein spyM18_0976 1 None None None 19745653 Common rnc ribonuclease III spyM18_0597 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 19747008 Pathogen - hypothetical protein spyM18_2209 1 None None None 19746497 Common - hypothetical protein spyM18_1567 40 COG3382 COG3382, Uncharacterized conserved protein Function unknown 19745915 Common - putative glycerophosphodiester phosphodiesterase spyM18_0899 92 COG4781 COG4781, Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase Energy production and conversion 19746711 Common - putative transcriptional regulator spyM18_1827 80 COG1846 MarR, Transcriptional regulators Transcription 19745520 Common - putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein spyM18_0412 236 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 19745576 Common - hypothetical protein spyM18_0489 1 None None None 19746392 Pathogen - putative holin spyM18_1450 1 COG5546 COG5546, Small integral membrane protein Function unknown 19745630 Common pepQ putative XAA-PRO dipeptidase spyM18_0571 248 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 19746365 Common - hypothetical protein spyM18_1411 1 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 19745829 Common sagB SagB spyM18_0800 36 COG0778 NfnB, Nitroreductase Energy production and conversion 19746871 Common polC DNA polymerase III PolC spyM18_2028 215 COG2176 PolC, DNA polymerase III, alpha subunit (gram-positive type) DNA replication, recombination, and repair 19745254 Common rpsN 30S ribosomal protein S14 spyM18_0065 196 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 19746634 Common - putative transcription regulator spyM18_1741 62 COG1316 LytR, Transcriptional regulator Transcription 19745344 Common araD L-ribulose-5-phosphate 4-epimerase spyM18_0178 143 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 19745781 Common - hypothetical protein spyM18_0746 13 COG1598 COG1598, Uncharacterized conserved protein Function unknown 19746920 Pathogen - hypothetical protein spyM18_2091 1 None None None 19746331 Common murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase spyM18_1371 210 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 19746415 Common - hypothetical protein spyM18_1475 8 None None None 19746823 Common - putative competence protein spyM18_1967 4 None None None 19745628 Common - putative lactoylglutathione lyase spyM18_0569 125 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 19745827 Common eno phosphopyruvate hydratase spyM18_0798 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 19746891 Common prmA ribosomal protein L11 methyltransferase spyM18_2052 180 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 19745299 Common hslO Hsp33-like chaperonin spyM18_0123 133 COG1281 COG1281, Disulfide bond chaperones of the HSP33 family Posttranslational modification, protein turnover, chaperones 19745734 Common - putative PTS dependent N-acetyl-galactosamine- and galactosamine IIA component spyM18_0698 55 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 19745249 Common rpmC 50S ribosomal protein L29 spyM18_0060 19 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 19746087 Common tdk thymidine kinase spyM18_1100 102 COG1435 Tdk, Thymidine kinase Nucleotide transport and metabolism 19745704 Common - putative protease spyM18_0660 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 19746486 Common coaD phosphopantetheine adenylyltransferase spyM18_1554 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 19746492 Common arcB ornithine carbamoyltransferase spyM18_1562 234 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 19746661 Pathogen - hypothetical protein spyM18_1775 1 None None None 19746841 Common - galactose-6-phosphate isomerase subunit LacA spyM18_1991 125 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 19746794 Common deoC putative deoxyribose-phosphate aldolase spyM18_1931 138 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 19746856 Pathogen - hypothetical protein spyM18_2010 1 None None None 19745799 Pathogen - hypothetical protein spyM18_0764 1 None None None 19746384 Common - phosphoglyceromutase spyM18_1439 158 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 19746935 Common - putative PTS system, enzyme III spyM18_2114 32 COG1447 CelC, Phosphotransferase system cellobiose-specific component IIA Carbohydrate transport and metabolism 19745751 Common - hypothetical protein spyM18_0715 54 COG1481 COG1481, Uncharacterized protein conserved in bacteria Function unknown 19746501 Common - bifunctional methionine sulfoxide reductase A/B protein spyM18_1571 206 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 19746111 Common - tRNA (uracil-5-)-methyltransferase Gid spyM18_1125 192 COG1206 Gid, NAD(FAD)-utilizing enzyme possibly involved in translation Translation, ribosomal structure and biogenesis 19746126 Common citX 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase spyM18_1141 24 COG3697 CitX, Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) Coenzyme metabolism / Lipid metabolism 19746465 Common - cell-division initiation protein spyM18_1532 38 COG3599 DivIVA, Cell division initiation protein Cell division and chromosome partitioning 19745479 Common - hypothetical protein spyM18_0363 53 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 19746817 Common tig trigger factor spyM18_1961 214 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 19745328 Common - adenylosuccinate synthetase spyM18_0156 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 19746006 Common - hypothetical protein spyM18_1003 159 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 19745617 Common coaE dephospho-CoA kinase spyM18_0556 208 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 19747025 Common - hypothetical protein spyM18_2228 97 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 19745355 Common - putative biotin synthase spyM18_0193 45 COG1268 BioY, Uncharacterized conserved protein General function prediction only 19746735 Common - hypothetical protein spyM18_1860 16 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 19745739 Common - hypothetical protein spyM18_0703 167 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 19746472 Common ftsQ cell division protein spyM18_1540 10 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 19745447 Common - hypothetical protein spyM18_0326 10 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 19745623 Common - putative glutamine cyclotransferase spyM18_0564 22 COG3823 COG3823, Glutamine cyclotransferase Posttranslational modification, protein turnover, chaperones 19746414 Common - hypothetical protein spyM18_1474 5 COG4626 COG4626, Phage terminase-like protein, large subunit General function prediction only 19745953 Common clpX ATP-dependent protease ATP-binding subunit spyM18_0946 231 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 19746341 Common - putative RNA helicase spyM18_1381 235 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 19746508 Common - hypothetical protein spyM18_1581 6 None None None 19745910 Common carA carbamoyl phosphate synthase small subunit spyM18_0893 237 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 19746596 Common glpK glycerol kinase spyM18_1696 179 COG0554 GlpK, Glycerol kinase Energy production and conversion 19746530 Common - hypothetical protein spyM18_1610 19 COG3538 COG3538, Uncharacterized conserved protein Function unknown 19746991 Common argR putative arginine repressor spyM18_2182 74 COG1438 ArgR, Arginine repressor Transcription 19746741 Common - putative ABC transporter spyM18_1867 71 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 19745906 Common sfhB hypothetical protein spyM18_0889 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 19745492 Pathogen - hypothetical protein spyM18_0376 1 None None None 19746809 Common - hypothetical protein spyM18_1949 213 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 19746725 Common - putative pyrazinamidase/nicotinamidase spyM18_1844 109 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 19746915 Common - putative histidine kinase spyM18_2083 215 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 19745233 Common ruvB Holliday junction DNA helicase B spyM18_0039 224 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 19745778 Common - hypothetical protein spyM18_0743 3 None None None 19746479 Common - hypothetical protein spyM18_1547 9 COG4483 COG4483, Uncharacterized protein conserved in bacteria Function unknown 19745215 Common prsA ribose-phosphate pyrophosphokinase spyM18_0021 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 19746036 Common - putative succinic semialdehyde dehydrogenase spyM18_1041 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 19746190 Common - hypothetical protein spyM18_1212 15 COG3237 COG3237, Uncharacterized protein conserved in bacteria Function unknown 19745293 Common - hypothetical protein spyM18_0117 1 None None None 19747046 Common spo0J putative chromosome segregation protein spyM18_2257 187 COG1475 Spo0J, Predicted transcriptional regulators Transcription 19745644 Common - hypothetical protein spyM18_0587 36 COG3412 COG3412, Uncharacterized protein conserved in bacteria Function unknown 19746890 Common - hypothetical protein spyM18_2051 157 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 19745283 Common - putative competence protein spyM18_0106 2 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 19745203 Common dnaN DNA polymerase III subunit beta spyM18_0002 214 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 19745608 Common - putative BlpM homologue spyM18_0544 2 None None None 19746217 Common - hypothetical protein spyM18_1242 3 None None None 19746212 Common - hypothetical protein spyM18_1237 1 None None None 19746875 Common uppS putative undecaprenyl pyrophosphate synthetase spyM18_2033 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 19746307 Common - hypothetical protein spyM18_1340 1 None None None 19746499 Common - putative histidine kinase spyM18_1569 108 COG2972 COG2972, Predicted signal transduction protein with a C-terminal ATPase domain Signal transduction mechanisms 19745875 Common - hypothetical protein spyM18_0855 27 COG1368 MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily Cell envelope biogenesis, outer membrane 19746918 Common - putative ABC transporter (ATP-binding protein) spyM18_2089 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 19746285 Common malE putative maltose/maltodextrin-binding protein spyM18_1314 67 COG2182 MalE, Maltose-binding periplasmic proteins/domains Carbohydrate transport and metabolism 19745565 Common - ribonucleotide-diphosphate reductase subunit alpha spyM18_0472 220 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 19745231 Common purB adenylosuccinate lyase spyM18_0037 239 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 19746924 Pathogen speB pyrogenic exotoxin B precursor spyM18_2099 4 None None None 19745272 Common adrC ABC transporter (ATP-binding protein) spyM18_0093 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 19746640 Common - hypothetical protein spyM18_1747 7 None None None 19746762 Common rpsR 30S ribosomal protein S18 spyM18_1895 215 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 19745405 Common fusA elongation factor G spyM18_0260 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 19746511 Common - hypothetical protein spyM18_1584 2 None None None 19745312 Common - putative acetyl-CoA:acetoacetyl-CoA transferase alpha subunit spyM18_0137 99 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 19746399 Common - hypothetical protein spyM18_1457 2 COG4722 COG4722, Phage-related protein Function unknown 19745685 Common - hypothetical protein spyM18_0636 109 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 19745539 Common fhuG putative ferrichrome ABC transporter (permease) spyM18_0436 190 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 19746826 Common hsdS putative specificity determinant HsdS spyM18_1975 66 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 19745406 Common gapA glyceraldehyde-3-phosphate dehydrogenase spyM18_0261 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 19746791 Common - DNA polymerase III subunit epsilon spyM18_1928 56 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 19745940 Common - putative secreted 5'-nucleotidase spyM18_0933 114 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 19746983 Common recA recombinase A spyM18_2174 217 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 19746118 Common - putative Mg2+/citrate complex transporter spyM18_1132 33 COG2851 CitM, H+/citrate symporter Energy production and conversion 19746402 Common - endonuclease domain-containing protein spyM18_1461 8 None None None 19746279 Pathogen - hypothetical protein spyM18_1308 1 None None None 19745563 Common nrdF ribonucleotide-diphosphate reductase subunit beta spyM18_0470 60 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 19745801 Common - hypothetical protein spyM18_0766 5 COG4722 COG4722, Phage-related protein Function unknown 19746089 Common hemK putative protoporphyrinogen oxidase spyM18_1102 227 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 19746708 Common - putative trans-2-enoyl-ACP reductase II spyM18_1823 137 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 19745377 Common - putative histidine kinase spyM18_0226 10 COG2972 COG2972, Predicted signal transduction protein with a C-terminal ATPase domain Signal transduction mechanisms 19746564 Common luxS S-ribosylhomocysteinase spyM18_1653 55 COG1854 LuxS, LuxS protein involved in autoinducer AI2 synthesis Signal transduction mechanisms 19746272 Pathogen - hypothetical protein spyM18_1301 1 None None None 19745530 Common - putative transposase spyM18_0426 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 19746833 Common - putative salivaricin A modification enzyme spyM18_1982 249 COG4403 LcnDR2, Lantibiotic modifying enzyme Defense mechanisms 19746917 Common - putative ABC transporter (ATP-binding protein) spyM18_2087 167 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 19746785 Common - putative transcriptional regulatory protein spyM18_1921 12 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 19745331 Pathogen nga nicotine adenine dinucleotide glycohydrolase precursor spyM18_0163 2 None None None 19746653 Pathogen - hypothetical protein spyM18_1765 1 None None None 19745532 Common - hypothetical protein spyM18_0428 123 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 19746143 Pathogen - hypothetical protein spyM18_1162 1 None None None 19745242 Common rplD 50S ribosomal protein L4 spyM18_0051 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 19745821 Common rplS 50S ribosomal protein L19 spyM18_0791 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 19746951 Common cspC putative cold shock protein spyM18_2136 184 COG1278 CspC, Cold shock proteins Transcription 19747001 Common rpmG 50S ribosomal protein L33 spyM18_2197 74 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 19745266 Common rpsK 30S ribosomal protein S11 spyM18_0078 247 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 19746766 Common mutY putative A/G-specific adenine glycosylase spyM18_1899 211 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 19746518 Common aroE putative shikimate 5-dehydrogenase spyM18_1592 225 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 19746862 Common - hypothetical protein spyM18_2017 23 COG3414 SgaB, Phosphotransferase system, galactitol-specific IIB component Carbohydrate transport and metabolism 19745580 Common mtsA putative metal binding protein of ABC transporter (lipoprotein) spyM18_0494 179 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 19746604 Common - hypothetical protein spyM18_1706 92 COG1283 NptA, Na+/phosphate symporter Inorganic ion transport and metabolism 19745691 Common - putative beta-glucosidase spyM18_0642 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 19745748 Common asnC asparaginyl-tRNA synthetase spyM18_0712 249 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 19745893 Common gshR glutathione reductase spyM18_0875 244 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 19746701 Common accD acetyl-CoA carboxylase subunit beta spyM18_1816 218 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 19746156 Common - hypothetical protein spyM18_1175 5 COG4684 COG4684, Predicted membrane protein Function unknown 19745228 Common purK phosphoribosylaminoimidazole carboxylase ATPase subunit spyM18_0034 193 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 19745814 Common - putative transcriptional regulator spyM18_0783 124 COG2188 PhnF, Transcriptional regulators Transcription 19746626 Common nusA transcription elongation factor NusA spyM18_1732 219 COG0195 NusA, Transcription elongation factor Transcription 19745765 Pathogen - hypothetical protein spyM18_0730 1 None None None 19746158 Common - putative sugar ABC transporter (permease protein) spyM18_1177 131 COG1079 COG1079, Uncharacterized ABC-type transport system, permease component General function prediction only 19745625 Common - hypothetical protein spyM18_0566 28 COG3817 COG3817, Predicted membrane protein Function unknown 19746074 Common - putative GTP pyrophosphokinase spyM18_1086 73 COG2357 COG2357, Uncharacterized protein conserved in bacteria Function unknown 19745363 Common - putative regulatory protein RofA related spyM18_0205 2 None None None 19746187 Pathogen - hypothetical protein spyM18_1209 1 None None None 19746476 Common typA putative GTP-binding protein spyM18_1544 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 19745698 Common ptsK HPr kinase/phosphorylase spyM18_0653 76 COG1493 HprK, Serine kinase of the HPr protein, regulates carbohydrate metabolism Signal transduction mechanisms 19746721 Pathogen - hypothetical protein spyM18_1838 1 None None None 19746106 Common - hypothetical protein spyM18_1120 6 None None None 19745267 Common rpoA DNA-directed RNA polymerase subunit alpha spyM18_0079 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 19746376 Common deaD putative ATP-dependent RNA helicase spyM18_1424 240 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 19745512 Common greA transcription elongation factor GreA spyM18_0402 202 COG0782 GreA, Transcription elongation factor Transcription 19745760 Pathogen - hypothetical protein spyM18_0725 1 None None None 19745522 Common - hypothetical protein spyM18_0414 14 COG4109 COG4109, Predicted transcriptional regulator containing CBS domains Transcription 19746231 Common - hypothetical protein spyM18_1260 5 None None None 19746588 Common - putative ABC transporter (ATP-binding protein) spyM18_1685 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 19746351 Common - hypothetical protein spyM18_1394 31 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 19745664 Common - putative nucleotide sugar dehydrogenase spyM18_0608 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 19746055 Common potC putative spermidine/putrescine ABC transporter (permease protein) spyM18_1066 187 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 19746199 Common - putative amino acid ABC transporter, periplasmic amino acid-binding protein spyM18_1223 172 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 19746557 Common - hypothetical protein spyM18_1643 76 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 19747016 Common dnaC replicative DNA helicase spyM18_2217 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 19746456 Common - putative phosphomannomutase spyM18_1521 234 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 19745548 Common - hypothetical protein spyM18_0447 8 COG4471 COG4471, Uncharacterized protein conserved in bacteria Function unknown 19745671 Common - hypothetical protein spyM18_0616 10 COG3077 RelB, DNA-damage-inducible protein J DNA replication, recombination, and repair 19745991 Common - putative endonuclease III (DNA repair) spyM18_0986 240 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 19745574 Common glmU putative UDP-N-acetylglucosamine pyrophosphorylase spyM18_0486 236 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 19746958 Common - putative formate-tetrahydrofolate ligase spyM18_2144 89 COG2759 MIS1, Formyltetrahydrofolate synthetase Nucleotide transport and metabolism 19746715 Common grpE putative Hsp-70 cofactor spyM18_1832 199 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 19745298 Common - hypothetical protein spyM18_0122 212 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 19746228 Common - putative minor tail protein spyM18_1257 21 COG5412 COG5412, Phage-related protein Function unknown 19745309 Common - putative short-chain fatty acids transporter spyM18_0134 42 COG2031 AtoE, Short chain fatty acids transporter Lipid metabolism 19746690 Common - hypothetical protein spyM18_1802 21 COG3645 COG3645, Uncharacterized phage-encoded protein Function unknown 19746086 Common - 4-oxalocrotonate tautomerase spyM18_1099 14 COG1942 COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog General function prediction only 19745417 Common - putative NifU protein spyM18_0277 164 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 19746942 Common - hypothetical protein spyM18_2122 1 None None None 19745527 Common - hypothetical protein spyM18_0419 186 COG0759 COG0759, Uncharacterized conserved protein Function unknown 19746699 Common serS seryl-tRNA synthetase spyM18_1814 247 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 19745886 Common rpmI 50S ribosomal protein L35 spyM18_0867 118 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 19745870 Common - putative rhamnosyltransferase spyM18_0846 122 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 19745334 Pathogen - hypothetical protein spyM18_0166 1 None None None 19746045 Common - hypothetical protein spyM18_1053 87 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 19745718 Pathogen - hypothetical protein spyM18_0677 1 None None None 19746867 Common - hypothetical protein spyM18_2024 1 None None None 19746716 Common hrcA heat-inducible transcription repressor spyM18_1833 144 COG1420 HrcA, Transcriptional regulator of heat shock gene Transcription 19746579 Common - putative ATP-dependent RNA helicase spyM18_1670 239 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 19746550 Common pnk putative protein kinase spyM18_1634 159 COG2815 COG2815, Uncharacterized protein conserved in bacteria Function unknown 19745359 Common - putative transposase spyM18_0199 55 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 19745945 Common mvd mevalonate pyrophosphate decarboxylase spyM18_0938 27 COG3407 MVD1, Mevalonate pyrophosphate decarboxylase Lipid metabolism 19745632 Common ccpA catabolite control protein A spyM18_0573 128 COG1609 PurR, Transcriptional regulators Transcription 19747040 Common - hypothetical protein spyM18_2247 51 COG1284 COG1284, Uncharacterized conserved protein Function unknown 19745550 Common - DNA polymerase III subunit delta' spyM18_0450 210 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 19746201 Common - putative amino acid ABC transporter (permease protein) spyM18_1225 172 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 19745412 Common - adaptor protein spyM18_0269 13 COG4862 MecA, Negative regulator of genetic competence, sporulation and motility Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion 19745500 Common - hypothetical protein spyM18_0386 10 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 19746080 Common - putative ABC transporter (ATP-binding protein) spyM18_1093 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 19747038 Common impd inositol-5-monophosphate dehydrogenase spyM18_2244 240 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 19746240 Common - hypothetical protein spyM18_1269 4 None None None 19746001 Common - putative fibronectin-binding protein-like protein A spyM18_0997 85 COG1293 COG1293, Predicted RNA-binding protein homologous to eukaryotic snRNP Transcription 19746254 Pathogen - hypothetical protein spyM18_1283 1 None None None 19746361 Common - putative 16S pseudouridylate synthetase spyM18_1406 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 19746314 Common - hypothetical protein spyM18_1348 2 None None None 19746363 Common queA S-adenosylmethionine:tRNA ribosyltransferase-isomerase spyM18_1408 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 19745507 Common - hypothetical protein spyM18_0394 1 None None None 19746390 Pathogen - hypothetical protein spyM18_1447 1 None None None 19746559 Common atoB putative acetyl-CoA:acetyltransferase spyM18_1645 187 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 19746277 Common - repressor protein spyM18_1306 14 COG2932 COG2932, Predicted transcriptional regulator Transcription 19745862 Common - putative ABC transporter (substrate-binding protein) spyM18_0837 179 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 19746294 Common - hypothetical protein spyM18_1325 3 None None None 19746938 Common - putative pyruvate formate-lyase activating enzyme spyM18_2117 69 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 19745984 Common hflX putative GTP-binding protein spyM18_0979 218 COG2262 HflX, GTPases General function prediction only 19745853 Common pheT phenylalanyl-tRNA synthetase subunit beta spyM18_0828 245 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 19745465 Common - putative DNA polymerase III delta prime subunit spyM18_0348 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 19745347 Common - putative glycine betaine/proline ABC transporter spyM18_0181 249 COG4175 ProV, ABC-type proline/glycine betaine transport system, ATPase component Amino acid transport and metabolism 19745594 Common - 67 kDa Myosin-crossreactive streptococcal antigen spyM18_0512 25 COG4716 COG4716, Myosin-crossreactive antigen Function unknown 19746048 Common folE GTP cyclohydrolase I spyM18_1059 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 19745641 Common - hypothetical protein spyM18_0584 10 COG1309 AcrR, Transcriptional regulator Transcription 19746013 Common acoL putative dihydrolipoamide dehydrogenase, component E3 spyM18_1013 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 19746773 Common - ribonuclease HIII spyM18_1906 28 COG1039 RnhC, Ribonuclease HIII DNA replication, recombination, and repair 19745847 Common atpD F0F1 ATP synthase subunit beta spyM18_0818 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 19745461 Pathogen - hypothetical protein spyM18_0343 1 None None None 19746417 Pathogen - hypothetical protein spyM18_1479 1 None None None 19746881 Common - leucine-rich protein spyM18_2041 5 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 19746532 Pathogen - N-terminal fragment of a histidine kinase spyM18_1614 1 None None None 19745639 Common - hypothetical protein spyM18_0582 28 COG3694 COG3694, ABC-type uncharacterized transport system, permease component General function prediction only 19745375 Common gltX glutamyl-tRNA synthetase spyM18_0223 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 19745365 Common hasC2 putative UDP-glucose pyrophosphorylase spyM18_0210 233 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 19746167 Common - putative response regulator spyM18_1187 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 19745481 Pathogen - hypothetical protein spyM18_0365 1 None None None 19746611 Common - tagatose-6-phosphate kinase spyM18_1715 29 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 19746819 Common - hypothetical protein spyM18_1963 16 COG4475 COG4475, Uncharacterized protein conserved in bacteria Function unknown 19746540 Common - hypothetical protein spyM18_1623 171 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 161484702 Common carB carbamoyl phosphate synthase large subunit spyM18_0895 236 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 19746405 Pathogen - hypothetical protein spyM18_1464 1 None None None 19746679 Pathogen - hypothetical protein spyM18_1793 1 None None None 19745682 Pathogen - hypothetical protein spyM18_0633 1 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 19745589 Common frr ribosome recycling factor spyM18_0506 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 19745702 Common - hypothetical protein spyM18_0658 1 None None None 19745891 Common aroC chorismate synthase spyM18_0872 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 19745841 Common atpL7 H+-transporting ATP synthase chain C spyM18_0812 5 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 19746937 Common - putative transcriptional regulator spyM18_2116 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 19746733 Common recG putative ATP-dependent DNA helicase spyM18_1857 221 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 19745951 Common dfr putative dihydrofolate reductase spyM18_0944 144 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 19745252 Common rplX 50S ribosomal protein L24 spyM18_0063 213 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 19745925 Common - putative regulatory protein spyM18_0910 14 COG3641 PfoR, Predicted membrane protein, putative toxin regulator General function prediction only 19746884 Common - (p)ppGpp synthetase spyM18_2045 207 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 19745666 Common - hypothetical protein spyM18_0610 9 COG3655 COG3655, Predicted transcriptional regulator Transcription 19746848 Pathogen - hypothetical protein spyM18_2002 1 None None None 19746207 Common dnaE DNA polymerase III DnaE spyM18_1232 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 19745494 Common - putative major tail protein spyM18_0379 4 None None None 19746270 Pathogen - hypothetical protein spyM18_1299 1 None None None 19745449 Common covS CovS spyM18_0329 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 19745396 Common - ribulose-phosphate 3-epimerase spyM18_0248 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 19746976 Common - hypothetical protein spyM18_2167 1 None None None 19746743 Common isp immunogenic secreted protein precursor homologue spyM18_1870 9 COG3942 COG3942, Surface antigen General function prediction only 19745510 Common - putative arylalkylamine n-acetyltransferase spyM18_0399 11 COG0456 RimI, Acetyltransferases General function prediction only 19746338 Common - hypothetical protein spyM18_1378 4 COG2339 COG2339, Predicted membrane protein Function unknown 19745792 Pathogen - hypothetical protein spyM18_0757 1 None None None 19746598 Common - hypothetical protein spyM18_1699 15 COG4224 COG4224, Uncharacterized protein conserved in bacteria Function unknown 19746010 Common acoA putative acetoin dehydrogenase (TPP-dependent) alpha chain spyM18_1009 155 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 19746670 Common - hypothetical protein spyM18_1784 53 COG1475 Spo0J, Predicted transcriptional regulators Transcription 19746197 Common - putative cation efflux system protein spyM18_1220 198 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 19745217 Common - fatty acid/phospholipid synthesis protein spyM18_0023 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 19746587 Common - hypothetical protein spyM18_1684 3 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 19745904 Common - putative capsular polysaccharide spyM18_0887 181 COG0583 LysR, Transcriptional regulator Transcription 19746839 Common - putative tagatose 6-phosphate kinase spyM18_1989 97 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 19745244 Common rplB 50S ribosomal protein L2 spyM18_0053 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 19746004 Common - putative ABC transport protein (permease) spyM18_1001 92 COG4120 COG4120, ABC-type uncharacterized transport system, permease component General function prediction only 19745831 Common - hypothetical protein spyM18_0802 14 COG1944 COG1944, Uncharacterized conserved protein Function unknown 19746907 Common - hypothetical protein spyM18_2071 15 None None None 19745223 Common purN phosphoribosylglycinamide formyltransferase spyM18_0029 220 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 19745732 Common - putative PTS dependent N-acetyl-galactosamine-IIB component spyM18_0696 39 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 19746703 Common fabZ (3R)-hydroxymyristoyl-(acyl carrier protein) dehydratase spyM18_1818 187 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 19746877 Common - hypothetical protein spyM18_2037 2 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 19746647 Common - hypothetical protein spyM18_1756 15 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 19745783 Common - hypothetical protein spyM18_0748 9 COG1403 McrA, Restriction endonuclease Defense mechanisms 19746830 Common - putative SalK homologue spyM18_1979 13 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 19745723 Common - hypothetical protein spyM18_0684 126 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 19745920 Common - putative cation-efflux system membrane protein spyM18_0905 166 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 19746756 Common efp elongation factor P spyM18_1887 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 19746178 Common spxA transcriptional regulator Spx spyM18_1198 68 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 19745429 Common - hypothetical protein spyM18_0303 95 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 19746996 Common - hypothetical protein spyM18_2187 71 COG1284 COG1284, Uncharacterized conserved protein Function unknown 19745325 Common - V-type ATP synthase subunit D spyM18_0153 41 COG1394 NtpD, Archaeal/vacuolar-type H+-ATPase subunit D Energy production and conversion 19745517 Common - hypothetical protein spyM18_0408 141 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 19746854 Common cysS cysteinyl-tRNA synthetase spyM18_2008 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 19745310 Common - putative transcriptional regulator spyM18_0135 173 COG0583 LysR, Transcriptional regulator Transcription 19746663 Common - putative minor capsid protein spyM18_1777 4 None None None 19746348 Common nrdF ribonucleotide-diphosphate reductase subunit beta spyM18_1389 149 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 19746484 Common - putative ribose transport operon repressor spyM18_1552 127 COG1609 PurR, Transcriptional regulators Transcription 19746008 Common - hypothetical protein spyM18_1007 1 None None None 19746494 Common arcA arginine deiminase spyM18_1564 57 COG2235 ArcA, Arginine deiminase Amino acid transport and metabolism 19746264 Pathogen - hypothetical protein spyM18_1293 1 None None None 19745318 Common - V-type ATP synthase subunit I spyM18_0144 42 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 19745368 Common - putative ABC transporter, ATP-binding protein spyM18_0214 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 19746684 Pathogen - hypothetical protein spyM18_1798 1 None None None 19746965 Common tsf elongation factor Ts spyM18_2152 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 19746897 Common - pai1 protein spyM18_2060 5 COG3153 COG3153, Predicted acetyltransferase General function prediction only 19746397 Common hylP hyaluronidase spyM18_1455 2 None None None 19746503 Common - putative cytochrome C-type biogenesis protein spyM18_1573 189 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 19745753 Pathogen - hypothetical protein spyM18_0717 1 None None None