Escherichia coli K12, complete genome NC_000913 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 90111490 Common ygcG predicted protein b2778 88 COG1512 COG1512, Beta-propeller domains of methanol dehydrogenase type General function prediction only 16130341 Common ptsH phosphohistidinoprotein-hexose phosphotransferase component of PTS system (Hpr) b2415 138 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 16131943 Common adiA biodegradative arginine decarboxylase b4117 86 COG1982 LdcC, Arginine/lysine/ornithine decarboxylases Amino acid transport and metabolism 16129814 Common ruvA component of RuvABC resolvasome, regulatory subunit b1861 210 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 16129239 Common pgpB phosphatidylglycerophosphatase B b1278 31 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 16129620 Common ribC riboflavin synthase, alpha subunit b1662 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 16131688 Common rfaH DNA-binding transcriptional antiterminator b3842 38 COG0250 NusG, Transcription antiterminator Transcription 90111405 Common yfaA predicted protein b2230 7 COG4685 COG4685, Uncharacterized protein conserved in bacteria Function unknown 16128639 Common insH IS5 transposase and trans-activator b0656 37 COG3039 COG3039, Transposase and inactivated derivatives, IS5 family DNA replication, recombination, and repair 16129230 Common rluB 23S rRNA pseudouridylate synthase b1269 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 16129970 Common gnd gluconate-6-phosphate dehydrogenase, decarboxylating b2029 187 COG0362 Gnd, 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 90111653 Common tatA TatABCE protein translocation system subunit b3836 51 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 16132030 Common cycA D-alanine/D-serine/glycine transporter b4208 172 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 16130715 Common gcvA DNA-binding transcriptional dual regulator b2808 190 COG0583 LysR, Transcriptional regulator Transcription 16129503 Common ydfK Qin prophage; predicted DNA-binding transcriptional regulator b1544 2 None None None 16129979 Common rfbA glucose-1-phosphate thymidylyltransferase b2039 233 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 16131229 Common kefB potassium:proton antiporter b3350 198 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 16128699 Common sdhB succinate dehydrogenase, FeS subunit b0724 202 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 16129247 Common rnb ribonuclease II b1286 192 COG4776 Rnb, Exoribonuclease II Transcription 16131966 Common yjeH predicted transporter b4141 84 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 16129461 Common ydeQ predicted fimbrial-like adhesin protein b1502 9 None None None 16128225 Common frsA hydrolase, binds to enzyme IIA(Glc) b0239 25 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 162135921 Common potB polyamine transporter subunit b1125 220 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 90111581 Common aroK shikimate kinase I b3390 200 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 16128757 Common ybhO cardiolipin synthase 2 b0789 142 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 16130892 Common hybE hydrogenase 2-specific chaperone b2992 21 None None None 16131230 Common kefG component of potassium effux complex with KefB b3351 63 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 16128268 Common yagQ conserved protein b0283 75 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 16129308 Common ydaC Rac prophage; predicted protein b1347 3 None None None 90111299 Common ynfC predicted protein b1585 6 None None None 16131090 Common lptA predicted transporter subunit: periplasmic-binding component of ABC superfamily b3200 69 COG1934 COG1934, Uncharacterized protein conserved in bacteria Function unknown 16130013 Common yegL conserved protein b2073 24 COG4245 TerY, Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain General function prediction only 90111193 Common ycbW predicted protein b0946 17 None None None 16130580 Common yqaE predicted membrane protein b2666 36 COG0401 COG0401, Uncharacterized homolog of Blt101 Function unknown 16131745 Common rhaS DNA-binding transcriptional activator, L-rhamnose-binding b3905 143 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 16131440 Common xylR DNA-binding transcriptional activator, xylose-binding b3569 121 COG1609 PurR, Transcriptional regulators Transcription 16129336 Common ynaE Rac prophage; predicted DNA-binding transcriptional regulator b1375 2 None None None 16130843 Common metK methionine adenosyltransferase 1 b2942 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 145698281 Common yeeJ adhesin b1978 148 COG2373 COG2373, Large extracellular alpha-helical protein General function prediction only 16131645 Common rffH glucose-1-phosphate thymidylyltransferase b3789 233 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 16131202 Common gspA general secretory pathway component, cryptic b3323 10 None None None 90111336 Common yoaB conserved protein b1809 108 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 49176333 Common yhdX predicted amino-acid transporter subunit b3269 173 COG4597 BatB, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 145698330 Common yieL predicted xylanase b3719 33 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 16129045 Common flgK flagellar hook-filament junction protein 1 b1082 126 COG1256 FlgK, Flagellar hook-associated protein Cell motility and secretion 16131866 Common ubiA p-hydroxybenzoate octaprenyltransferase b4040 166 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 16130361 Common hemF coproporphyrinogen III oxidase b2436 113 COG0408 HemF, Coproporphyrinogen III oxidase Coenzyme metabolism 16129798 Common ptrB protease II b1845 100 COG1770 PtrB, Protease II Amino acid transport and metabolism 16128241 Common insI KpLE2 phage-like element; IS30 transposase b0256 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 16128351 Common tauB taurine transporter subunit b0366 249 COG4525 TauB, ABC-type taurine transport system, ATPase component Inorganic ion transport and metabolism 16130431 Common yfgI conserved protein b2506 4 None None None 16130286 Common yfdK CPS-53 (KpLE1) prophage; conserved protein b2354 8 None None None 16131699 Common yihD conserved protein b3858 18 COG3084 COG3084, Uncharacterized protein conserved in bacteria Function unknown 16131676 Common yigM predicted inner membrane protein b3827 40 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 90111250 Common mppA murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit b1329 203 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 16129861 Common uvrY DNA-binding response regulator in two-component regulatory system with BarA b1914 214 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 90111523 Common pppA bifunctional prepilin leader peptidase/ methylase b2972 136 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 16130395 Common acrD aminoglycoside/multidrug efflux system b2470 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 90111468 Common smpA small membrane lipoprotein b2617 59 COG2913 SmpA, Small protein A (tmRNA-binding) Translation, ribosomal structure and biogenesis 90111356 Common fliZ predicted regulator of FliA activity b1921 9 None None None 16128235 Common ykfB CP4-6 prophage; predicted protein b0250 2 None None None 16128895 Common aspC aspartate aminotransferase, PLP-dependent b0928 73 COG1448 TyrB, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 49176071 Common rutA predicted monooxygenase b1012 77 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 16132176 Common tsr methyl-accepting chemotaxis protein I, serine sensor receptor b4355 148 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 16132148 Common yjiE predicted DNA-binding transcriptional regulator b4327 126 COG0583 LysR, Transcriptional regulator Transcription 16128597 Common citX apo-citrate lyase phosphoribosyl-dephospho-CoA transferase b0614 24 COG3697 CitX, Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) Coenzyme metabolism / Lipid metabolism 90111276 Common yncC predicted DNA-binding transcriptional regulator b1450 93 COG1802 GntR, Transcriptional regulators Transcription 49176133 Common mdtK multidrug efflux system transporter b1663 166 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 16131846 Common yjbB predicted transporter b4020 80 COG1283 NptA, Na+/phosphate symporter Inorganic ion transport and metabolism 49176260 Common srlA glucitol/sorbitol-specific enzyme IIC component of PTS b2702 22 COG3730 SrlA, Phosphotransferase system sorbitol-specific component IIC Carbohydrate transport and metabolism 16130651 Common surE broad specificity 5'(3')-nucleotidase and polyphosphatase b2744 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 16128444 Common hha modulator of gene expression, with H-NS b0460 12 None None None 16130717 Common csdA cysteine sulfinate desulfinase b2810 238 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 16128585 Common ybdN conserved protein b0602 18 COG3969 COG3969, Predicted phosphoadenosine phosphosulfate sulfotransferase General function prediction only 16131620 Common rbsK ribokinase b3752 198 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 16128276 Common yagX predicted aromatic compound dioxygenase b0291 10 COG3188 FimD, P pilus assembly protein, porin PapC Cell motility and secretion / Intracellular trafficking and secretion 90111692 Common yjeI conserved protein b4144 17 None None None 90111135 Common bolA regulator of penicillin binding proteins and beta lactamase transcription (morphogene) b0435 105 COG0271 BolA, Stress-induced morphogen (activity unknown) Signal transduction mechanisms 16130723 Common recD exonuclease V (RecBCD complex), alpha chain b2819 142 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 16128060 Common thiQ thiamin transporter subunit b0066 249 COG3840 ThiQ, ABC-type thiamine transport system, ATPase component Coenzyme metabolism 16128818 Common ybjC predicted inner membrane protein b0850 7 None None None 16129615 Common ydhP predicted transporter b1657 159 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16131370 Common prlC oligopeptidase A b3498 126 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 90111511 Common ygfB predicted protein b2909 37 COG3079 COG3079, Uncharacterized protein conserved in bacteria Function unknown 16131740 Common frvA predicted enzyme IIA component of PTS b3900 115 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 16131154 Common acrF multidrug efflux system protein b3266 178 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 94541114 Common yobH predicted protein b4536 8 None None None 16131787 Common frwC predicted enzyme IIC component of PTS b3949 67 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 16131379 Common dctR predicted DNA-binding ranscriptional regulator b3507 2 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 16130741 Common galR DNA-binding transcriptional repressor b2837 128 COG1609 PurR, Transcriptional regulators Transcription 16128826 Common ybjO predicted inner membrane protein b0858 9 None None None 16130426 Common ppk polyphosphate kinase, component of RNA degradosome b2501 161 COG0855 Ppk, Polyphosphate kinase Inorganic ion transport and metabolism 49176395 Common gyrB DNA gyrase, subunit B b3699 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 16132199 Common deoA thymidine phosphorylase b4382 118 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 16129649 Common aroD 3-dehydroquinate dehydratase b1693 55 COG0710 AroD, 3-dehydroquinate dehydratase Amino acid transport and metabolism 16129558 Common mdtJ multidrug efflux system transporter b1600 141 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 16131784 Common fsaB fructose-6-phosphate aldolase 2 b3946 117 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 90111719 Common yjhC KpLE2 phage-like element; predicted oxidoreductase b4280 174 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 16131176 Common rpsK 30S ribosomal subunit protein S11 b3297 248 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 16129310 Common recT Rac prophage; recombination and repair protein b1349 27 COG3723 RecT, Recombinational DNA repair protein (RecE pathway) DNA replication, recombination, and repair 16128385 Common phoR sensory histidine kinase in two-component regulatory system with PhoB b0400 222 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 16129529 Common dicA Qin prophage; predicted regulator for DicB b1570 21 COG1396 HipB, Predicted transcriptional regulators Transcription 16132118 Common yjhG KpLE2 phage-like element; predicted dehydratase b4297 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 90111518 Common yggU conserved protein b2953 69 COG1872 COG1872, Uncharacterized conserved protein Function unknown 16131465 Common yibA lyase containing HEAT-repeat b3594 7 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 16129363 Common insD KpLE2 phage-like element; IS2 insertion element transposase InsAB' b1402 92 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 16131997 Common hflC modulator for HflB protease specific for phage lambda cII repressor b4175 153 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 16132141 Common fimH minor component of type 1 fimbriae b4320 6 None None None 16129219 Common yciF conserved protein b1258 37 COG3685 COG3685, Uncharacterized protein conserved in bacteria Function unknown 16131971 Common yjeK predicted lysine aminomutase b4146 126 COG1509 KamA, Lysine 2,3-aminomutase Amino acid transport and metabolism 90111574 Common yhfK conserved inner membrane protein b3358 55 COG1289 COG1289, Predicted membrane protein Function unknown 16131934 Common yjdM conserved protein b4108 107 COG2824 PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism Inorganic ion transport and metabolism 16130059 Common yehP conserved protein b2121 26 COG3552 CoxE, Protein containing von Willebrand factor type A (vWA) domain General function prediction only 16131129 Common yhcO predicted barnase inhibitor b3239 9 COG2732 COG2732, Barstar, RNAse (barnase) inhibitor Transcription 90111550 Common deaD ATP-dependent RNA helicase b3162 235 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 16128110 Common yacH predicted protein b0117 32 COG4372 COG4372, Uncharacterized protein conserved in bacteria with the myosin-like domain Function unknown 16128533 Common rusA DLP12 prophage; endonuclease RUS b0550 7 COG4570 Rus, Holliday junction resolvase DNA replication, recombination, and repair 16128623 Common holA DNA polymerase III, delta subunit b0640 70 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 16131692 Common fadB fused 3-hydroxybutyryl-CoA epimerase/delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase/enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase b3846 191 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 16129273 Common ycjP predicted sugar transporter subunit: membrane component of ABC superfamily b1312 164 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 16131622 Common hsrA predicted multidrug or homocysteine efflux system b3754 198 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16131214 Common gspO bifunctional prepilin leader peptidase/ methylase b3335 92 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 16129884 Common fliE flagellar basal-body component b1937 71 COG1677 FliE, Flagellar hook-basal body protein Cell motility and secretion / Intracellular trafficking and secretion 16129933 Common cobS cobalamin 5'-phosphate synthase b1992 140 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 16130949 Common glnE fused deadenylyltransferase/adenylyltransferase for glutamine synthetase b3053 119 COG1391 GlnE, Glutamine synthetase adenylyltransferase Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms 16129703 Common xthA exonuclease III b1749 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 16129399 Common ydcS predicted spermidine/putrescine transporter subunit b1440 114 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 16127997 Common thrB homoserine kinase b0003 129 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 16128738 Common ybhI predicted transporter b0770 107 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 90111630 Common yicN conserved protein b3663 8 None None None 16129317 Common racR Rac prophage; predicted DNA-binding transcriptional regulator b1356 4 None None None 16129745 Common yeaN predicted transporter b1791 77 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 16129058 Common fabF 3-oxoacyl-[acyl-carrier-protein] synthase II b1095 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 16128094 Common yacG conserved protein b0101 60 COG3024 COG3024, Uncharacterized protein conserved in bacteria Function unknown 16131889 Common soxR DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing b4063 86 COG0789 SoxR, Predicted transcriptional regulators Transcription 16132094 Common insD KpLE2 phage-like element; IS2 insertion element transposase InsAB' b4273 92 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 16128022 Common fkpB FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) b0028 130 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 90111559 Common nanT sialic acid transporter b3224 209 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16129908 Common yedJ predicted phosphohydrolase b1962 62 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 16128488 Common allS DNA-binding transcriptional activator of the allD operon b0504 172 COG0583 LysR, Transcriptional regulator Transcription 16130384 Common eutT predicted cobalamin adenosyltransferase in ethanolamine utilization b2459 12 COG4812 EutT, Ethanolamine utilization cobalamin adenosyltransferase Amino acid transport and metabolism 16131681 Common rmuC predicted recombination limiting protein b3832 147 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 16128391 Common tgt tRNA-guanine transglycosylase b0406 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 90111649 Common wzzE Entobacterial Common Antigen (ECA) polysaccharide chain length modulation protein b3785 16 COG3765 WzzB, Chain length determinant protein Cell envelope biogenesis, outer membrane 16128557 Common cusB copper/silver efflux system, membrane fusion protein b0574 127 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 16128542 Common ybcW DLP12 prophage; predicted protein b0559 1 None None None 16128424 Common lon DNA-binding ATP-dependent protease La b0439 216 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 145698219 Common yadB glutamyl-Q tRNA(Asp) synthetase b0144 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 16131856 Common psiE predicted phosphate starvation inducible protein b4030 21 COG3223 COG3223, Predicted membrane protein Function unknown 16131264 Common rpe D-ribulose-5-phosphate 3-epimerase b3386 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 16129162 Common dhaL dihydroxyacetone kinase, C-terminal domain b1199 76 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 16130417 Common focB predicted formate transporter b2492 89 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 16128527 Common ybcK DLP12 prophage; predicted recombinase b0544 39 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 16128838 Common ltaE L-allo-threonine aldolase, PLP-dependent b0870 114 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 16131814 Common rplA 50S ribosomal subunit protein L1 b3984 238 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 90111711 Common yjgF ketoacid-binding protein b4243 183 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 16131817 Common rpoB RNA polymerase, beta subunit b3987 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 16128724 Common galM galactose-1-epimerase (mutarotase) b0756 96 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 16129129 Common ymgB predicted protein b1166 2 None None None 162135913 Common envC protease with a role in cell division b3613 200 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 16131308 Common yhgN predicted antibiotic transporter b3434 148 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 16129774 Common yobD conserved inner membrane protein b1820 16 COG4811 COG4811, Predicted membrane protein Function unknown 16131921 Common phnM carbon-phosphorus lyase complex subunit b4095 52 COG3454 COG3454, Metal-dependent hydrolase involved in phosphonate metabolism Inorganic ion transport and metabolism 16128720 Common zitB zinc efflux system b0752 178 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 16129998 Common wcaB predicted acyl transferase b2058 197 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 16130823 Common yggE conserved protein b2922 85 COG2968 COG2968, Uncharacterized conserved protein Function unknown 16130213 Common nuoL NADH:ubiquinone oxidoreductase, membrane subunit L b2278 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 16128005 Common yaaW conserved protein b0011 8 COG4735 COG4735, Uncharacterized protein conserved in bacteria Function unknown 90111218 Common mnmA tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase b1133 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 16130963 Common rpoD RNA polymerase, sigma 70 (sigma D) factor b3067 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 16128605 Common pagP palmitoyl transferase for Lipid A b0622 14 None None None 16131873 Common yjbL predicted protein b4047 2 None None None 16130907 Common yghB conserved inner membrane protein b3009 95 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 90111436 Common eutK predicted carboxysome structural protein with predicted role in ethanolamine utilization b2438 5 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 90111609 Common bcsA cellulose synthase, catalytic subunit b3533 121 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 16130374 Nonpathogen yffR CPZ-55 prophage; predicted protein b2449 1 None None None 90111735 Common yjiM predicted 2-hydroxyglutaryl-CoA dehydratase b4335 34 COG1775 HgdB, Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB Amino acid transport and metabolism 16129429 Common yddJ predicted protein b1470 2 None None None 16129928 Common yeeO predicted multidrug efflux system b1985 164 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 16131796 Common argC N-acetyl-gamma-glutamylphosphate reductase, NAD(P)-binding b3958 216 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 16129004 Common csgB curlin nucleator protein, minor subunit in curli complex b1041 17 None None None 16130802 Common yqfB conserved protein b2900 16 COG3097 COG3097, Uncharacterized protein conserved in bacteria Function unknown 16129608 Common nemA N-ethylmaleimide reductase, FMN-linked b1650 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 145698270 Common ynhF hypothetical protein b4602 1 None None None 16131596 Common pstS phosphate transporter subunit b3728 138 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 16129650 Common ydiF fused predicted acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit/beta subunit b1694 99 COG4670 COG4670, Acyl CoA:acetate/3-ketoacid CoA transferase Lipid metabolism 16128502 Common fdrA predicted acyl-CoA synthetase with NAD(P)-binding Rossmann-fold domain b0518 126 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 16128950 Common gfcD conserved protein b0984 23 None None None 16128202 Common dnaQ DNA polymerase III epsilon subunit b0215 182 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 16131954 Common yjdK predicted protein b4128 2 None None None 16130875 Common glcA glycolate transporter b2975 104 COG1620 LldP, L-lactate permease Energy production and conversion 16129890 Common fliK flagellar hook-length control protein b1943 46 COG3144 FliK, Flagellar hook-length control protein Cell motility and secretion 16128712 Common tolQ membrane spanning protein in TolA-TolQ-TolR complex b0737 148 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 16130176 Common glpA sn-glycerol-3-phosphate dehydrogenase (anaerobic), large subunit, FAD/NAD(P)-binding b2241 163 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 16128273 Common ykgJ predicted ferredoxin b0288 21 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 16128671 Common kdpD fused sensory histidine kinase in two-component regulatory system with KdpE: signal sensing protein b0695 221 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 16131312 Common yhhX predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain b3440 166 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 49176295 Common glcE glycolate oxidase FAD binding subunit b4468 151 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 16128086 Common ftsQ membrane anchored protein involved in growth of wall at septum b0093 74 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 16131627 Common ilvM acetolactate synthase II, small subunit b3769 22 COG3978 COG3978, Acetolactate synthase (isozyme II), small (regulatory) subunit Function unknown 16128731 Common modA molybdate transporter subunit b0763 161 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 90111341 Common rsmF predicted methyltransferase b1835 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 16130028 Common insF IS3 element protein InsF b2089 149 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 16129725 Common ydjG predicted oxidoreductase b1771 203 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 16130241 Common hisP histidine/lysine/arginine/ornithine transporter subunit b2306 249 COG4598 HisP, ABC-type histidine transport system, ATPase component Amino acid transport and metabolism 16131243 Common tsgA predicted transporter b3364 62 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 162135900 Common dhaK dihydroxyacetone kinase, N-terminal domain b1200 77 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 90111619 Common aldB aldehyde dehydrogenase B b3588 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 16131196 Common rplB 50S ribosomal subunit protein L2 b3317 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 16128573 Common fepD iron-enterobactin transporter subunit b0590 190 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 16129575 Common uidA beta-D-glucuronidase b1617 71 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 16129472 Common lsrA fused AI2 transporter subunits of ABC superfamily: ATP-binding components b1513 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 16129541 Common ynfB predicted protein b1583 11 None None None 16128729 Common modE DNA-binding transcriptional dual regulator b0761 59 COG2005 ModE, N-terminal domain of molybdenum-binding protein General function prediction only 16131445 Common yiaJ predicted DNA-binding transcriptional repressor b3574 122 COG1414 IclR, Transcriptional regulator Transcription 16130623 Common ascB cryptic 6-phospho-beta-glucosidase b2716 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 16130031 Common gatB galactitol-specific enzyme IIB component of PTS b2093 15 COG3414 SgaB, Phosphotransferase system, galactitol-specific IIB component Carbohydrate transport and metabolism 16128319 Common prpD 2-methylcitrate dehydratase b0334 66 COG2079 PrpD, Uncharacterized protein involved in propionate catabolism General function prediction only 16131168 Common rsmB 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent b3289 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 16131106 Common yhcD predicted outer membrane protein b3216 32 COG3188 FimD, P pilus assembly protein, porin PapC Cell motility and secretion / Intracellular trafficking and secretion 16128988 Common pgaA predicted outer membrane protein b1024 18 None None None 16131124 Common degQ serine endoprotease, periplasmic b3234 221 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 16130182 Common yfaW predicted enolase b2247 97 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 16131415 Common dppB dipeptide transporter b3543 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 16132086 Common idnR DNA-binding transcriptional repressor, 5-gluconate-binding b4264 128 COG1609 PurR, Transcriptional regulators Transcription 16130368 Nonpathogen yffL CPZ-55 prophage; predicted protein b2443 1 None None None 162135907 Common yphG conserved protein b2549 14 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 16131488 Common kbl glycine C-acetyltransferase b3617 191 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 16129300 Common abgR predicted DNA-binding transcriptional regulator b1339 193 COG0583 LysR, Transcriptional regulator Transcription 16129137 Common minE cell division topological specificity factor b1174 80 COG0851 MinE, Septum formation topological specificity factor Cell division and chromosome partitioning 49176418 Common rarD predicted chloramphenical resistance permease b3819 117 COG2962 RarD, Predicted permeases General function prediction only 90111504 Common hyuA D-stereospecific phenylhydantoinase b2873 206 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 16130696 Common gudP predicted D-glucarate transporter b2789 204 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 90111111 Common ykgI predicted protein b0303 3 None None None 16131353 Common nikR DNA-binding transcriptional repressor, Ni-binding b3481 60 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 16129803 Common eda multifunctional 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase and oxaloacetate decarboxylase b1850 126 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 145698244 Common ymgJ hypothetical protein b4594 1 None None None 145698316 Common pnp polynucleotide phosphorylase/polyadenylase b3164 241 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 16132138 Common fimD outer membrane usher protein, type 1 fimbrial synthesis b4317 34 COG3188 FimD, P pilus assembly protein, porin PapC Cell motility and secretion / Intracellular trafficking and secretion 16128297 Common betB betaine aldehyde dehydrogenase, NAD-dependent b0312 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 16131074 Common yhbE conserved inner membrane protein b3184 73 COG2962 RarD, Predicted permeases General function prediction only 49175993 Common caiC predicted crotonobetaine CoA ligase:carnitine CoA ligase b0037 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 16131368 Common yhiP predicted transporter b3496 81 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 16129266 Common pspB DNA-binding transcriptional regulator of psp operon b1305 23 None None None 16130540 Common intA CP4-57 prophage; integrase b2622 105 COG0582 XerC, Integrase DNA replication, recombination, and repair 16128705 Common mngR DNA-binding transcriptional dual regulator, fatty-acyl-binding b0730 154 COG2188 PhnF, Transcriptional regulators Transcription 16130189 Common arnC undecaprenyl phosphate-L-Ara4FN transferase b2254 207 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 16128340 Common frmB predicted esterase b0355 106 COG0627 COG0627, Predicted esterase General function prediction only 16130497 Common rseA anti-sigma factor b2572 32 COG3073 RseA, Negative regulator of sigma E activity Signal transduction mechanisms 90111171 Common ybiM predicted protein b0806 10 None None None 16128685 Common ybgI conserved metal-binding protein b0710 101 COG0327 COG0327, Uncharacterized conserved protein Function unknown 16128885 Common kdsB 3-deoxy-manno-octulosonate cytidylyltransferase b0918 139 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 145698342 Common ytcA hypothetical protein b4622 4 None None None 16128010 Common insL IS186/IS421 transposase b0016 14 COG3385 COG3385, FOG: Transposase and inactivated derivatives DNA replication, recombination, and repair 16128364 Common yaiY predicted inner membrane protein b0379 6 None None None 16130999 Common yhaI predicted inner membrane protein b3104 49 COG3152 COG3152, Predicted membrane protein Function unknown 16131033 Common agaI galactosamine-6-phosphate isomerase b3141 73 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 16128172 Common lpxD UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase b0179 178 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 16131898 Common nrfC formate-dependent nitrite reductase, 4Fe4S subunit b4072 163 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 16131392 Common yhjB predicted DNA-binding response regulator in two-component regulatory system b3520 153 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 145698325 Common bisC biotin sulfoxide reductase b3551 179 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 90111132 Common yajQ predicted nucleotide binding protein b0426 107 COG1666 COG1666, Uncharacterized protein conserved in bacteria Function unknown 49176443 Common cpxP periplasmic protein combats stress b4484 17 COG3678 CpxP, P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism 90111524 Common yghU predicted S-transferase b2989 97 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 16130557 Nonpathogen yfjW CP4-57 prophage; predicted inner membrane protein b2642 1 None None None 16131436 Common xylA D-xylose isomerase b3565 68 COG2115 XylA, Xylose isomerase Carbohydrate transport and metabolism 16131148 Common dusB tRNA-dihydrouridine synthase B b3260 209 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 16128857 Common ftsK DNA-binding membrane protein required for chromosome resolution and partitioning b0890 199 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 94541127 Common yibT predicted protein b4554 5 None None None 16130478 Common glnB regulatory protein P-II for glutamine synthetase b2553 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 90111085 Common secM regulator of secA translation b0097 11 None None None 16128326 Common cynX predicted cyanate transporter b0341 70 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 16130092 Common yeiG predicted esterase b2154 95 COG0627 COG0627, Predicted esterase General function prediction only 49176448 Common thiS sulphur carrier protein b4407 27 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 16128773 Common fiu predicted iron outer membrane transporter b0805 109 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 16131919 Common phnO predicted acyltransferase with acyl-CoA N-acyltransferase domain b4093 54 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 16128552 Common nfrB bacteriophage N4 receptor, inner membrane subunit b0569 29 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 90111302 Common dmsD twin-argninine leader-binding protein for DmsA and TorA b1591 27 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 16128291 Common ykgE predicted oxidoreductase b0306 154 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 16128142 Common mrcB fused glycosyl transferase and transpeptidase b0149 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 16131410 Common bcsG predicted inner membrane protein b3538 18 None None None 16131525 Common yicE predicted transporter b3654 127 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 16128149 Common yadR conserved protein b0156 166 COG0316 IscA, Uncharacterized conserved protein Function unknown 16130694 Common gudD (D)-glucarate dehydratase 1 b2787 57 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 16130083 Common yeiS predicted inner membrane protein b2145 4 None None None 16128478 Common tesA multifunctional acyl-CoA thioesterase I and protease I and lysophospholipase L1 b0494 98 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 90111353 Common yecT predicted protein b1877 3 COG3755 COG3755, Uncharacterized protein conserved in bacteria Function unknown 16131170 Common mscL mechanosensitive channel b3291 143 COG1970 MscL, Large-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 16132044 Common ytfP conserved protein b4222 30 COG2105 COG2105, Uncharacterized conserved protein Function unknown 90111103 Common ykfA CP4-6 prophage; predicted GTP-binding protein b0253 42 COG3596 COG3596, Predicted GTPase General function prediction only 16128923 Common ycbG conserved protein b0956 17 COG3120 COG3120, Uncharacterized protein conserved in bacteria Function unknown 90111200 Common torS hybrid sensory histidine kinase in two-component regulatory system with TorR b0993 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 49176011 Common betI DNA-binding transcriptional repressor b0313 64 COG1309 AcrR, Transcriptional regulator Transcription 16130480 Common yfhG conserved protein b2555 10 None None None 90111482 Common ygbF predicted protein b2754 31 None None None 16130160 Common atoE short chain fatty acid transporter b2223 39 COG2031 AtoE, Short chain fatty acids transporter Lipid metabolism 90111382 Common yegP predicted protein b2080 30 COG3422 COG3422, Uncharacterized conserved protein Function unknown 16131771 Common ftsN essential cell division protein b3933 22 COG3087 FtsN, Cell division protein Cell division and chromosome partitioning 16131910 Common alsK D-allose kinase b4084 152 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 16128453 Common apt adenine phosphoribosyltransferase b0469 190 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 16128473 Common qmcA predicted protease, membrane anchored b0489 220 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 16130512 Common kgtP alpha-ketoglutarate transporter b2587 126 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16129568 Common tus inhibitor of replication at Ter, DNA-binding protein b1610 14 None None None 162135893 Common hrpB predicted ATP-dependent helicase b0148 133 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 16128668 Common potE putrescine/proton symporter: putrescine/ornithine antiporter b0692 176 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 16129889 Common fliJ flagellar protein b1942 40 COG2882 FliJ, Flagellar biosynthesis chaperone Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 16131429 Common insK IS150 conserved protein InsB b3558 154 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 49176170 Common fliA RNA polymerase, sigma 28 (sigma F) factor b1922 216 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 49176177 Common flu CP4-44 prophage; antigen 43 (Ag43) phase-variable biofilm formation autotransporter b2000 108 COG3468 AidA, Type V secretory pathway, adhesin AidA Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 16132188 Common fhuF ferric iron reductase involved in ferric hydroximate transport b4367 17 COG4114 FhuF, Uncharacterized Fe-S protein General function prediction only 16132123 Common sgcA KpLE2 phage-like element; predicted phosphotransferase enzyme IIA component b4302 40 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 90111176 Common ybjI conserved protein b0844 126 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 16130190 Common arnA fused UDP-L-Ara4N formyltransferase/UDP-GlcA C-4'-decarboxylase b2255 245 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 90111099 Common yafS predicted S-adenosyl-L-methionine-dependent methyltransferase b0213 55 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 90111202 Common rutF predicted oxidoreductase, flavin:NADH component b1007 101 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 16128422 Common clpP proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP-dependent serine proteases b0437 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 16130927 Common yqiA predicted esterase b3031 47 COG3150 COG3150, Predicted esterase General function prediction only 16130133 Common ccmF heme lyase, CcmF subunit b2196 160 COG1138 CcmF, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 90111326 Common ynjI predicted inner membrane protein b1762 3 None None None 16128047 Common surA peptidyl-prolyl cis-trans isomerase (PPIase) b0053 162 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 16130258 Common fabB 3-oxoacyl-[acyl-carrier-protein] synthase I b2323 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 16128162 Common rpsB 30S ribosomal subunit protein S2 b0169 226 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 16128794 Common moeB molybdopterin synthase sulfurylase b0826 223 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 16131545 Common yidG predicted inner membrane protein b3675 6 None None None 16130799 Common ygfY conserved protein b2897 50 COG2938 COG2938, Uncharacterized conserved protein Function unknown 16131136 Common yhdE conserved protein b3248 198 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 16130490 Common recO gap repair protein b2565 83 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 145698331 Common yifB predicted bifunctional enzyme and transcriptional regulator b3765 200 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 16129155 Common ldcA L,D-carboxypeptidase A b1192 81 COG1619 LdcA, Uncharacterized proteins, homologs of microcin C7 resistance protein MccF Defense mechanisms 16129353 Common paaE predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation b1392 141 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 16130195 Common menE o-succinylbenzoate-CoA ligase b2260 212 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 16128007 Common yaaI predicted protein b0013 4 None None None 90111483 Common ygcI predicted protein b2757 36 None None None 16128036 Common fixB predicted electron transfer flavoprotein, NAD/FAD-binding domain and ETFP adenine nucleotide-binding domain-like protein b0042 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 16128458 Common adk adenylate kinase b0474 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 16131274 Common nudE ADP-ribose diphosphatase b3397 112 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 90111123 Common hemB porphobilinogen synthase b0369 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 16131286 Common feoC predicted DNA-binding transcriptional regulator b3410 9 COG1378 COG1378, Predicted transcriptional regulators Transcription 16131035 Common yraI predicted periplasmic pilin chaperone b3143 24 COG3121 FimC, P pilus assembly protein, chaperone PapD Cell motility and secretion / Intracellular trafficking and secretion 16131760 Common yiiS conserved protein b3922 16 COG3691 COG3691, Uncharacterized protein conserved in bacteria Function unknown 16128615 Common dacA D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) b0632 155 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 16130312 Common ypdA predicted sensory kinase in two-component system with YpdB b2380 105 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 16130297 Common dsdX predicted transporter b2365 79 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 16128703 Common sucC succinyl-CoA synthetase, beta subunit b0728 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 16129659 Common ydiA conserved protein b1703 113 COG1806 COG1806, Uncharacterized protein conserved in bacteria Function unknown 16128464 Common ushA bifunctional UDP-sugar hydrolase/5'-nucleotidase b0480 139 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 16130520 Common pheA fused chorismate mutase P/prephenate dehydratase b2599 214 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 16131908 Common mdtN predicted membrane fusion protein of efflux pump b4082 138 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 16131462 Common selA selenocysteine synthase b3591 73 COG1921 SelA, Selenocysteine synthase [seryl-tRNASer selenium transferase] Amino acid transport and metabolism 16129087 Common potC polyamine transporter subunit b1124 217 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 16128852 Common aat leucyl/phenylalanyl-tRNA-protein transferase b0885 134 COG2360 Aat, Leu/Phe-tRNA-protein transferase Posttranslational modification, protein turnover, chaperones 16132067 Common pyrB aspartate carbamoyltransferase, catalytic subunit b4245 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 90111235 Common ychM predicted transporter b1206 156 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 16130469 Common yphB conserved protein b2544 37 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 90111455 Common yphC predicted oxidoreductase, Zn-dependent and NAD(P)-binding b2545 205 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 90111506 Common ssnA predicted chlorohydrolase/aminohydrolase b2879 130 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 16129735 Common yeaE predicted oxidoreductase b1781 201 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 16131565 Common yidA predicted hydrolase b3697 142 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 16132208 Common yjjK fused predicted transporter subunits of ABC superfamily: ATP-binding components b4391 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 16131185 Common rpsH 30S ribosomal subunit protein S8 b3306 242 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 16128944 Common appC cytochrome bd-II oxidase, subunit I b0978 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 90111610 Common bcsF predicted protein b3537 6 None None None 16130516 Common yfiO predicted lipoprotein b2595 126 COG4105 ComL, DNA uptake lipoprotein General function prediction only 16132217 Common creD inner membrane protein b4400 29 COG4452 CreD, Inner membrane protein involved in colicin E2 resistance Defense mechanisms 145698347 Common yjjN predicted oxidoreductase, Zn-dependent and NAD(P)-binding b4358 205 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 16130604 Common alaS alanyl-tRNA synthetase b2697 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 90111094 Common yaeI predicted phosphatase b0164 98 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 16131555 Common ibpA heat shock chaperone b3687 67 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 16128433 Common mdlA fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components b0448 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 49176407 Common rep DNA helicase and single-stranded DNA-dependent ATPase b3778 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 16129992 Common fcl bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase/ GDP-4-dehydro-6-L-deoxygalactose reductase b2052 222 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 90111257 Common ydaG Rac prophage; predicted protein b1355 1 None None None 90111152 Common ahpF alkyl hydroperoxide reductase, F52a subunit, FAD/NAD(P)-binding b0606 246 COG3634 AhpF, Alkyl hydroperoxide reductase, large subunit Posttranslational modification, protein turnover, chaperones 16129964 Common hisH imidazole glycerol phosphate synthase, glutamine amidotransferase subunit with HisF b2023 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 16130445 Common yfhM conserved protein b2520 79 COG2373 COG2373, Large extracellular alpha-helical protein General function prediction only 16132143 Common uxuA mannonate hydrolase b4322 58 COG1312 UxuA, D-mannonate dehydratase Carbohydrate transport and metabolism 16131878 Common dnaB replicative DNA helicase b4052 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 16128101 Common ppdD predicted major pilin subunit b0108 37 COG4969 PilA, Tfp pilus assembly protein, major pilin PilA Cell motility and secretion / Intracellular trafficking and secretion 16130970 Common ebgR DNA-binding transcriptional repressor b3075 125 COG1609 PurR, Transcriptional regulators Transcription 16128304 Common yahE predicted protein b0319 7 None None None 16132059 Common nrdG anaerobic ribonucleotide reductase activating protein b4237 63 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 16128128 Common yadC predicted fimbrial-like adhesin protein b0135 3 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16132169 Common hsdS specificity determinant for hsdM and hsdR b4348 83 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 94541095 Common ykgN predicted IS protein b4505 63 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 16130104 Common yeiC predicted kinase b2166 132 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 16130167 Common ubiG bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase b2232 173 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 49176267 Common ygcU predicted FAD containing dehydrogenase b4463 194 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 16128788 Common ybiT fused predicted transporter subunits of ABC superfamily: ATP-binding components b0820 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 16129166 Common ychF predicted GTP-binding protein b1203 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 16131131 Common aaeA p-hydroxybenzoic acid efflux system component b3241 155 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 16129380 Common trg methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor b1421 140 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 16128184 Common yaeJ conserved protein b0191 125 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 16131245 Common nirD nitrite reductase, NAD(P)H-binding, small subunit b3366 45 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 16128396 Common tsx nucleoside channel, receptor of phage T6 and colicin K b0411 18 COG3248 Tsx, Nucleoside-binding outer membrane protein Cell envelope biogenesis, outer membrane 16129191 Common ychS predicted protein b1228 1 None None None 16131506 Common mutM formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase b3635 180 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 145698322 Common yhjC predicted DNA-binding transcriptional regulator b3521 182 COG0583 LysR, Transcriptional regulator Transcription 16129862 Common yecF predicted protein b1915 10 None None None 16130349 Common cysU sulfate/thiosulfate transporter subunit b2424 228 COG0555 CysU, ABC-type sulfate transport system, permease component Posttranslational modification, protein turnover, chaperones 90111461 Common yfiC predicted S-adenosyl-L-methionine-dependent methyltransferase b2575 27 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 145698292 Common fadL long-chain fatty acid outer membrane transporter b2344 78 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 16128967 Common yccE predicted protein b1001 2 None None None 16129340 Common hslJ heat-inducible protein b1379 13 COG3187 HslJ, Heat shock protein Posttranslational modification, protein turnover, chaperones 16128658 Common ybfN predicted lipoprotein b0682 8 None None None 16128651 Common nagD UMP phosphatase b0675 109 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 16130376 Common eutA reactivating factor for ethanolamine ammonia lyase b2451 17 COG4819 EutA, Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition Amino acid transport and metabolism 90111495 Common yqeH conserved protein with bipartite regulator domain b2846 5 COG2771 CsgD, DNA-binding HTH domain-containing proteins Transcription 16131235 Common yhfA conserved protein b3356 86 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 16130284 Nonpathogen yfdI CPS-53 (KpLE1) prophage; predicted inner membrane protein b2352 2 None None None 90111639 Common yidR conserved protein b3689 12 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 16129077 Common mfd transcription-repair coupling factor b1114 234 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 16130662 Common ygbT conserved protein b2755 46 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 16130644 Common ygbK conserved protein b2737 57 COG3395 COG3395, Uncharacterized protein conserved in bacteria Function unknown 16130049 Common yehD predicted fimbrial-like adhesin protein b2111 4 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16128716 Common pal peptidoglycan-associated outer membrane lipoprotein b0741 148 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 162135916 Common ytfB predicted cell envelope opacity-associated protein b4206 14 COG3061 OapA, Cell envelope opacity-associated protein A Cell envelope biogenesis, outer membrane 16131066 Common glmM phosphoglucosamine mutase b3176 241 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 16128915 Common rlmL predicted methyltransferase b0948 162 COG0116 COG0116, Predicted N6-adenine-specific DNA methylase DNA replication, recombination, and repair 145698237 Common ymbA conserved protein b0952 29 COG3009 COG3009, Uncharacterized protein conserved in bacteria Function unknown 90111632 Common uhpC membrane protein regulates uhpT expression b3667 155 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 16131751 Common cpxA sensory histidine kinase in two-component regulatory system with CpxR b3911 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 16128252 Common yagA CP4-6 prophage; predicted DNA-binding transcriptional regulator b0267 95 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 16130671 Common cysJ sulfite reductase, alpha subunit, flavoprotein b2764 106 COG0369 CysJ, Sulfite reductase, alpha subunit (flavoprotein) Inorganic ion transport and metabolism 16130736 Common ygdQ predicted inner membrane protein b2832 95 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 90111624 Common dfp fused 4'-phosphopantothenoylcysteine decarboxylase/phosphopantothenoylcysteine synthetase, FMN-binding b3639 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 16129022 Common solA N-methyltryptophan oxidase, FAD-binding b1059 51 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 16131734 Common fdoG formate dehydrogenase-O, large subunit b3894 185 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 16130952 Common cca fused tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase and phosphatase b3056 195 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 16131579 Common yidZ predicted DNA-binding transcriptional regulator b3711 87 COG0583 LysR, Transcriptional regulator Transcription 16129283 Common ycjF conserved inner membrane protein b1322 42 COG3768 COG3768, Predicted membrane protein Function unknown 90111245 Common puuD gamma-Glu-GABA hydrolase b1298 121 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 16128984 Common phoH conserved protein with nucleoside triphosphate hydrolase domain b1020 198 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 16131117 Common dcuD predicted transporter b3227 24 COG3069 DcuC, C4-dicarboxylate transporter Energy production and conversion 16129070 Common nagZ beta N-acetyl-glucosaminidase b1107 175 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 90111748 Common yjjX thiamin metabolism associated protein b4394 35 COG1986 COG1986, Uncharacterized conserved protein Function unknown 16130487 Common yfhL predicted 4Fe-4S cluster-containing protein b2562 103 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 16131383 Common hdeD acid-resistance membrane protein b3511 16 COG3247 HdeD, Uncharacterized conserved protein Function unknown 90111213 Common ycfP conserved protein b1108 21 COG3150 COG3150, Predicted esterase General function prediction only 16129758 Common rnd ribonuclease D b1804 120 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 16130909 Common yqhD alcohol dehydrogenase, NAD(P)-dependent b3011 168 COG1979 COG1979, Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family Energy production and conversion 16131001 Common yhaK predicted pirin-related protein b3106 97 COG1741 COG1741, Pirin-related protein General function prediction only 16130005 Common dcd 2'-deoxycytidine 5'-triphosphate deaminase b2065 158 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 16129482 Common yneG conserved protein b1523 15 None None None 16129372 Common ynbD predicted phosphatase, inner membrane protein b1411 27 COG2453 CDC14, Predicted protein-tyrosine phosphatase Signal transduction mechanisms 16130150 Common ada fused DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase b2213 190 COG2169 Ada, Adenosine deaminase Nucleotide transport and metabolism 16131341 Common zntA zinc, cobalt and lead efflux system b3469 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 16129661 Common ydiE conserved protein b1705 6 COG4256 HemP, Hemin uptake protein Inorganic ion transport and metabolism 145698337 Common argB acetylglutamate kinase b3959 208 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 16129187 Common narG nitrate reductase 1, alpha subunit b1224 114 COG5013 NarG, Nitrate reductase alpha subunit Energy production and conversion 16129205 Common oppB oligopeptide transporter subunit b1244 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 16132024 Common rpsR 30S ribosomal subunit protein S18 b4202 214 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 49176018 Common araJ predicted transporter b0396 159 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16130338 Common zipA cell division protein involved in Z ring assembly b2412 44 COG3115 ZipA, Cell division protein Cell division and chromosome partitioning 90111443 Common gcvR DNA-binding transcriptional repressor, regulatory protein accessory to GcvA b2479 31 COG2716 GcvR, Glycine cleavage system regulatory protein Amino acid transport and metabolism 90111557 Common elbB isoprenoid biosynthesis protein with amidotransferase-like domain b3209 38 COG3155 ElbB, Uncharacterized protein involved in an early stage of isoprenoid biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 16129982 Common galF predicted subunit with GalU b2042 230 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 16128169 Common rseP zinc metallopeptidase b0176 211 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 49176207 Common nuoA NADH:ubiquinone oxidoreductase, membrane subunit A b2288 162 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 16130614 Common srlR DNA-bindng transcriptional repressor b2707 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 90111703 Common ulaA L-ascorbate-specific enzyme IIC component of PTS b4193 36 COG3037 SgaT, Uncharacterized protein conserved in bacteria Function unknown 16129841 Common motB protein that enables flagellar motor rotation b1889 114 COG1360 MotB, Flagellar motor protein Cell motility and secretion 16129100 Common ymfD e14 prophage; predicted SAM-dependent methyltransferase b1137 4 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 90111376 Common gmm GDP-mannose mannosyl hydrolase b2051 24 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 16131495 Common rfaZ lipopolysaccharide core biosynthesis protein b3624 6 None None None 90111340 Common yebT conserved protein b1834 56 COG3008 PqiB, Paraquat-inducible protein B General function prediction only 16130669 Common cysH 3'-phosphoadenosine 5'-phosphosulfate reductase b2762 154 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 16131658 Common cyaA adenylate cyclase b3806 25 COG3072 CyaA, Adenylate cyclase Nucleotide transport and metabolism 16130119 Common yejG predicted protein b2181 11 None None None 16131763 Common glpX fructose 1,6-bisphosphatase II b3925 112 COG1494 GlpX, Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins Carbohydrate transport and metabolism 16130458 Common suhB inositol monophosphatase b2533 217 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 90111678 Common plsB glycerol-3-phosphate O-acyltransferase b4041 48 COG2937 PlsB, Glycerol-3-phosphate O-acyltransferase Lipid metabolism 90111537 Common exuR DNA-binding transcriptional repressor b3094 132 COG2186 FadR, Transcriptional regulators Transcription 16128877 Common cmk cytidylate kinase b0910 204 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 94541107 Common ymiA hypothetical protein b4522 5 None None None 16129851 Common araF L-arabinose transporter subunit b1901 38 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 16131709 Common glnL sensory histidine kinase in two-component regulatory system with GlnG b3869 219 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 16129819 Common aspS aspartyl-tRNA synthetase b1866 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 16130331 Common xapR DNA-binding transcriptional activator b2405 191 COG0583 LysR, Transcriptional regulator Transcription 16130835 Common cmtB predicted mannitol-specific enzyme IIA component of PTS b2934 39 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 49176239 Common purL phosphoribosylformyl-glycineamide synthetase b2557 232 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 16128564 Common ybdK gamma-glutamyl:cysteine ligase b0581 60 COG2170 COG2170, Uncharacterized conserved protein Function unknown 16129225 Common trpE component I of anthranilate synthase b1264 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 16130635 Common hypC protein required for maturation of hydrogenases 1 and 3 b2728 77 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 145698230 Common ybeZ predicted protein with nucleoside triphosphate hydrolase domain b0660 199 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 16131373 Common arsR DNA-binding transcriptional repressor b3501 166 COG0640 ArsR, Predicted transcriptional regulators Transcription 90111530 Common yqiC conserved protein b3042 52 COG2960 COG2960, Uncharacterized protein conserved in bacteria Function unknown 90111392 Common yehT predicted response regulator in two-component system withYehU b2125 211 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 145698229 Common ylcI hypothetical protein b4589 1 None None None 16129442 Common ddpF D-ala-D-ala transporter subunit b1483 249 COG1124 DppF, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 16131630 Common ilvA threonine deaminase b3772 221 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 16130296 Common dsdC DNA-binding transcriptional dual regulator b2364 177 COG0583 LysR, Transcriptional regulator Transcription 49176276 Common ygeW conserved protein b2870 231 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 16131830 Common hupA HU, DNA-binding transcriptional regulator, alpha subunit b4000 211 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 16129034 Common flgM anti-sigma factor for FliA (sigma 28) b1071 12 COG2747 FlgM, Negative regulator of flagellin synthesis (anti-sigma28 factor) Transcription / Cell motility and secretion / Intracellular trafficking and secretion 90111690 Common aspA aspartate ammonia-lyase b4139 219 COG1027 AspA, Aspartate ammonia-lyase Amino acid transport and metabolism 16129926 Common amn AMP nucleosidase b1982 54 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 16130304 Common yfdV predicted transporter b2372 58 COG0679 COG0679, Predicted permeases General function prediction only 16129500 Common ydfZ conserved protein b1541 7 None None None 16129961 Common hisD bifunctional histidinal dehydrogenase/ histidinol dehydrogenase b2020 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 16131087 Common kdsD D-arabinose 5-phosphate isomerase b3197 151 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 16129729 Common ydjK predicted transporter b1775 127 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 16128084 Common murC UDP-N-acetylmuramate:L-alanine ligase b0091 209 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 16130913 Common sufI repressor protein for FtsI b3017 84 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 16129390 Common ydcL predicted lipoprotein b1431 12 None None None 16131259 Common yhfX predicted amino acid racemase b3381 14 COG3457 COG3457, Predicted amino acid racemase Amino acid transport and metabolism 16128632 Common djlC Hsc56 co-chaperone of HscC b0649 6 None None None 16131782 Common yijF conserved protein b3944 17 COG3738 COG3738, Uncharacterized protein conserved in bacteria Function unknown 16128505 Common ybcF predicted carbamate kinase b0521 66 COG0549 ArcC, Carbamate kinase Amino acid transport and metabolism 16129640 Common sufA Fe-S cluster assembly protein b1684 161 COG0316 IscA, Uncharacterized conserved protein Function unknown 145698284 Common yojO hypothetical protein b4604 1 None None None 16129157 Common ycgR protein involved in flagellar function b1194 19 COG5581 COG5581, Predicted glycosyltransferase Cell envelope biogenesis, outer membrane 90111178 Common ybjS predicted NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain b0868 126 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 16130990 Common yqjA conserved inner membrane protein b3095 156 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 16132121 Common sgcR KpLE2 phage-like element; predicted DNA-binding transcriptional regulator b4300 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 16129516 Common cspB Qin prophage; cold shock protein b1557 182 COG1278 CspC, Cold shock proteins Transcription 16128416 Common cyoB cytochrome o ubiquinol oxidase subunit I b0431 165 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 16130519 Nonpathogen pheL pheA gene leader peptide b2598 1 None None None 49176316 Common tdcE pyruvate formate-lyase 4/2-ketobutyrate formate-lyase b3114 59 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 16129002 Common csgE predicted transport protein b1039 10 None None None 16128630 Common ybeT conserved outer membrane protein b0647 100 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 16128828 Common artJ arginine transporter subunit b0860 179 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 16129319 Common ydaT Rac prophage; predicted protein b1358 5 None None None 16132206 Common radA predicted repair protein b4389 217 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 16129365 Common insI KpLE2 phage-like element; IS30 transposase b1404 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 49176335 Common yrdD predicted DNA topoisomerase b3283 133 COG0551 TopA, Zn-finger domain associated with topoisomerase type I DNA replication, recombination, and repair 16131427 Common cspA major cold shock protein b3556 181 COG1278 CspC, Cold shock proteins Transcription 16129466 Common hipA regulator with hipB b1507 69 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 16128188 Common yaeB conserved protein b0195 95 COG1720 COG1720, Uncharacterized conserved protein Function unknown 16128750 Common moaB molybdopterin biosynthesis protein B b0782 187 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 16132057 Common pmbA predicted peptidase required for the maturation and secretion of the antibiotic peptide MccB17 b4235 157 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 16131306 Common glgB 1,4-alpha-glucan branching enzyme b3432 149 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 16128644 Common miaB isopentenyl-adenosine A37 tRNA methylthiolase b0661 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 16130666 Nonpathogen ygcK predicted protein b2759 4 None None None 16130428 Common yfgF predicted inner membrane protein b2503 162 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 16132060 Common nrdD anaerobic ribonucleoside-triphosphate reductase b4238 100 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 16128702 Common sucB dihydrolipoyltranssuccinase b0727 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 16131467 Common yibG conserved protein b3596 4 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 16129499 Common ydfH predicted DNA-binding transcriptional regulator b1540 136 COG1802 GntR, Transcriptional regulators Transcription 16128069 Common leuL leu operon leader peptide b0075 2 None None None 16128367 Common iraP predicted protein b0382 6 None None None 16130411 Common hyfF hydrogenase 4, membrane subunit b2486 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 162135911 Common mrcA fused penicillin-binding protein 1a: murein transglycosylase/murein transpeptidase b3396 200 COG5009 MrcA, Membrane carboxypeptidase/penicillin-binding protein Cell envelope biogenesis, outer membrane 16131887 Common yjcC predicted signal transduction protein (EAL domain containing protein) b4061 163 COG4943 COG4943, Predicted signal transduction protein containing sensor and EAL domains Signal transduction mechanisms 16130947 Common yqiK conserved protein b3051 43 COG2268 COG2268, Uncharacterized protein conserved in bacteria Function unknown 90111296 Common ydfT Qin prophage; predicted antitermination protein Q b1559 6 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 90111141 Common ybbM predicted inner membrane protein b0491 70 COG0390 COG0390, ABC-type uncharacterized transport system, permease component General function prediction only 16131127 Common argR DNA-binding transcriptional dual regulator, L-arginine-binding b3237 75 COG1438 ArgR, Arginine repressor Transcription 90111697 Common orn oligoribonuclease b4162 88 COG1949 Orn, Oligoribonuclease (3'->5' exoribonuclease) RNA processing and modification 16131104 Common gltF periplasmic protein b3214 7 None None None 16128596 Common citG triphosphoribosyl-dephospho-CoA transferase b0613 48 COG1767 CitG, Triphosphoribosyl-dephospho-CoA synthetase Coenzyme metabolism 16131403 Common bcsZ endo-1,4-D-glucanase b3531 33 COG3405 CelA, Endoglucanase Y Carbohydrate transport and metabolism 16129743 Common yeaL conserved inner membrane protein b1789 28 COG2707 COG2707, Predicted membrane protein Function unknown 90111516 Common yqgE predicted protein b2948 130 COG1678 COG1678, Putative transcriptional regulator Transcription 16128974 Common rutE predicted oxidoreductase b1008 51 COG0778 NfnB, Nitroreductase Energy production and conversion 16129598 Common anmK conserved protein b1640 120 COG2377 COG2377, Predicted molecular chaperone distantly related to HSP70-fold metalloproteases Posttranslational modification, protein turnover, chaperones 16128209 Common yafJ predicted amidotransfease b0223 72 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 16131827 Common hemE uroporphyrinogen decarboxylase b3997 181 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 16129055 Common fabD malonyl-CoA-[acyl-carrier-protein] transacylase b1092 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 16129036 Common flgB flagellar component of cell-proximal portion of basal-body rod b1073 99 COG1815 FlgB, Flagellar basal body protein Cell motility and secretion 16128099 Common hofC assembly protein in type IV pilin biogenesis, transmembrane protein b0106 144 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 16130068 Common yehY predicted transporter subunit: membrane component of ABC superfamily b2130 101 COG1174 OpuBB, ABC-type proline/glycine betaine transport systems, permease component Amino acid transport and metabolism 16131606 Common atpB F0 sector of membrane-bound ATP synthase, subunit a b3738 206 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 16131254 Common yhfS conserved protein b3376 8 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 16128343 Common yaiO predicted protein b0358 2 None None None 90111237 Common yciI predicted enzyme b1251 76 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 16130629 Common hycD hydrogenase 3, membrane subunit b2722 179 COG0650 HyfC, Formate hydrogenlyase subunit 4 Energy production and conversion 16132158 Common mdtM multidrug efflux system protein b4337 214 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16130509 Common yfiQ fused predicted acyl-CoA synthetase: NAD(P)-binding subunit/ATP-binding subunit b2584 149 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 16129312 Common racC Rac prophage; predicted protein b1351 3 None None None 16129906 Common vsr DNA mismatch endonuclease of very short patch repair b1960 71 COG3727 Vsr, DNA G:T-mismatch repair endonuclease DNA replication, recombination, and repair 16130434 Common xseA exonuclease VII, large subunit b2509 205 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 49176430 Common fadA 3-ketoacyl-CoA thiolase (thiolase I) b3845 179 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 16129237 Common acnA aconitate hydratase 1 b1276 222 COG1048 AcnA, Aconitase A Energy production and conversion 90111688 Common eptA predicted metal dependent hydrolase b4114 64 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 16132032 Common ytfF predicted inner membrane protein b4210 42 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 16129375 Common ydcF conserved protein b1414 11 COG1434 COG1434, Uncharacterized conserved protein Function unknown 145698346 Common yjiW conserved protein b4347 5 None None None 16128688 Common ybgL predicted lactam utilization protein b0713 100 COG1540 COG1540, Uncharacterized proteins, homologs of lactam utilization protein B General function prediction only 16128810 Common cmr multidrug efflux system protein b0842 203 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16128697 Common sdhD succinate dehydrogenase, membrane subunit, binds cytochrome b556 b0722 53 COG2142 SdhD, Succinate dehydrogenase, hydrophobic anchor subunit Energy production and conversion 16129214 Common yciA predicted hydrolase b1253 130 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 90111586 Common hslO heat shock protein Hsp33 b3401 138 COG1281 COG1281, Disulfide bond chaperones of the HSP33 family Posttranslational modification, protein turnover, chaperones 90111128 Common mak manno(fructo)kinase b0394 162 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 16131968 Common groL Cpn60 chaperonin GroEL, large subunit of GroESL b4143 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 16128803 Common yliG predicted SAM-dependent methyltransferase b0835 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 16132042 Common ytfM predicted outer membrane protein and surface antigen b4220 129 COG0729 COG0729, Outer membrane protein Cell envelope biogenesis, outer membrane 16130804 Common ygfF predicted NAD(P)-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain b2902 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 145698246 Common dhaM fused predicted dihydroxyacetone-specific PTS enzymes: HPr component/EI component b1198 136 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 16128429 Common queC predicted aluminum resistance protein b0444 175 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 90111427 Common insL IS186/IS421 transposase b2394 14 COG3385 COG3385, FOG: Transposase and inactivated derivatives DNA replication, recombination, and repair 90111362 Common yedW predicted DNA-binding response regulator in two-component system with YedV b1969 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 16131747 Common rhaT L-rhamnose:proton symporter b3907 14 None None None 90111195 Common mgsA methylglyoxal synthase b0963 88 COG1803 MgsA, Methylglyoxal synthase Carbohydrate transport and metabolism 90111403 Common napB nitrate reductase, small, cytochrome C550 subunit, periplasmic b2203 40 COG3043 NapB, Nitrate reductase cytochrome c-type subunit Energy production and conversion 16128078 Common murE UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-diaminopimelate ligase b0085 207 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 16129762 Common yoaA conserved protein with nucleoside triphosphate hydrolase domain b1808 145 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 16130846 Common endA DNA-specific endonuclease I b2945 33 COG2356 EndA, Endonuclease I DNA replication, recombination, and repair 16130044 Common rcnA membrane protein conferring nickel and cobalt resistance b2106 32 COG2215 COG2215, ABC-type uncharacterized transport system, permease component General function prediction only 16131860 Common malE maltose transporter subunit b4034 97 COG2182 MalE, Maltose-binding periplasmic proteins/domains Carbohydrate transport and metabolism 16128227 Common phoE outer membrane phosphoporin protein E b0241 30 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 16129796 Common yobB conserved protein b1843 6 COG0388 COG0388, Predicted amidohydrolase General function prediction only 16131451 Common lyx L-xylulose kinase b3580 179 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 16130393 Common aegA fused predicted oxidoreductase: FeS binding subunit/NAD/FAD-binding subunit b2468 216 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 49176343 Common yhfZ conserved protein b3383 12 None None None 16130539 Common smpB trans-translation protein b2620 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 16129047 Common rne fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein b1084 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 16128893 Common ycbK conserved protein b0926 63 COG3108 COG3108, Uncharacterized protein conserved in bacteria Function unknown 16128446 Common acrB multidrug efflux system protein b0462 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 16132049 Common ytfQ predicted sugar transporter subunit: periplasmic-binding component of ABC superfamily b4227 105 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 16128283 Common insE IS3 element protein InsE b0298 32 None None None 16132174 Common yjiX conserved protein b4353 27 COG2879 COG2879, Uncharacterized small protein Function unknown 16129768 Common sdaA L-serine deaminase I b1814 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 16129583 Common cnu predicted regulator b1625 12 None None None 16130821 Common scpC propionyl-CoA:succinate-CoA transferase b2920 94 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 16128033 Common caiA crotonobetaine reductase subunit II, FAD-binding b0039 160 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 16128081 Common murD UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase b0088 208 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 90111288 Common yneI predicted aldehyde dehydrogenase b1525 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 16129410 Common yncD predicted iron outer membrane transporter b1451 126 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 16129245 Common yciT predicted DNA-binding transcriptional regulator b1284 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 90111247 Common ycjM predicted glucosyltransferase b1309 127 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 16129916 Common yedX conserved protein b1970 64 COG2351 COG2351, Transthyretin-like protein General function prediction only 16131413 Common dppD dipeptide transporter b3541 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 90111655 Common yihF conserved protein b3861 17 COG5339 COG5339, Uncharacterized protein conserved in bacteria Function unknown 16131677 Common metR DNA-binding transcriptional activator, homocysteine-binding b3828 165 COG0583 LysR, Transcriptional regulator Transcription 16129533 Common dicB Qin prophage; cell division inhibition protein b1575 1 None None None 16129946 Common yeeV CP4-44 prophage; toxin of the YeeV-YeeU toxin-antitoxin system b2005 8 None None None 16129684 Common ydjO predicted protein b1730 2 None None None 16128795 Common moeA molybdopterin biosynthesis protein b0827 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 16131727 Common dtd D-tyr-tRNA(Tyr) deacylase b3887 139 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 16128682 Common ybgA conserved protein b0707 49 COG3272 COG3272, Uncharacterized conserved protein Function unknown 90111521 Common nupG nucleoside transporter b2964 48 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 90111626 Common dinD DNA-damage-inducible protein b3645 21 None None None 16129813 Common ruvB ATP-dependent DNA helicase, component of RuvABC resolvasome b1860 233 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 16129877 Common yedF conserved protein b1930 30 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 16131945 Common melA alpha-galactosidase, NAD(P)-binding b4119 54 COG1486 CelF, Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases Carbohydrate transport and metabolism 16128220 Common yafP predicted acyltransferase with acyl-CoA N-acyltransferase domain b0234 52 COG0456 RimI, Acetyltransferases General function prediction only 16130307 Common yfdX predicted protein b2375 5 None None None 16130621 Common ascG DNA-binding transcriptional repressor b2714 127 COG1609 PurR, Transcriptional regulators Transcription 16131769 Common hslU molecular chaperone and ATPase component of HslUV protease b3931 214 COG1220 HslU, ATP-dependent protease HslVU (ClpYQ), ATPase subunit Posttranslational modification, protein turnover, chaperones 16128813 Common ybjJ predicted transporter b0845 72 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 16130861 Common trmI tRNA (m7G46) methyltransferase, SAM-dependent b2960 178 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 16130852 Common yggS predicted enzyme b2951 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 90111572 Common gspM general secretory pathway component, cryptic b3334 3 COG3149 PulM, Type II secretory pathway, component PulM Intracellular trafficking and secretion 16128579 Common entA 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase b0596 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 16129427 Common narZ nitrate reductase 2 (NRZ), alpha subunit b1468 104 COG5013 NarG, Nitrate reductase alpha subunit Energy production and conversion 16131072 Common dacB D-alanyl-D-alanine carboxypeptidase b3182 110 COG2027 DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) Cell envelope biogenesis, outer membrane 49176326 Common arcB hybrid sensory histidine kinase in two-component regulatory system with ArcA b3210 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 16128733 Common modC molybdate transporter subunit b0765 249 COG4148 ModC, ABC-type molybdate transport system, ATPase component Inorganic ion transport and metabolism 16129654 Common ydiR predicted electron transfer flavoprotein, FAD-binding b1698 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 16129578 Common malI DNA-binding transcriptional repressor b1620 122 COG1609 PurR, Transcriptional regulators Transcription 16128191 Common metI DL-methionine transporter subunit b0198 212 COG2011 AbcD, ABC-type metal ion transport system, permease component Inorganic ion transport and metabolism 16129636 Common sufS selenocysteine lyase, PLP-dependent b1680 239 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 16132016 Common ulaB L-ascorbate-specific enzyme IIB component of PTS b4194 16 COG3414 SgaB, Phosphotransferase system, galactitol-specific IIB component Carbohydrate transport and metabolism 16129625 Common ydhT conserved protein b1669 6 None None None 16130698 Common truC tRNA pseudouridine synthase b2791 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 16130401 Common purC phosphoribosylaminoimidazole-succinocarboxamide synthetase b2476 204 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 90111661 Common yihX predicted hydrolase b3885 70 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 49176416 Common hemC hydroxymethylbilane synthase b3805 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 16131738 Common frvX predicted endo-1,4-beta-glucanase b3898 91 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 16130226 Common yfbR deoxyribonucleoside 5'-monophosphatase b2291 35 COG1896 COG1896, Predicted hydrolases of HD superfamily General function prediction only 16129292 Common insH IS5 transposase and trans-activator b1331 37 COG3039 COG3039, Transposase and inactivated derivatives, IS5 family DNA replication, recombination, and repair 16129674 Common infC protein chain initiation factor IF-3 b1718 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 145698340 Common dusA tRNA-dihydrouridine synthase A b4049 203 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 16129111 Common ymfM e14 prophage; predicted protein b1148 1 None None None 16128710 Common ybgE conserved inner membrane protein b0735 15 COG3790 COG3790, Predicted membrane protein Function unknown 16130495 Common rseC RseC protein involved in reduction of the SoxR iron-sulfur cluster b2570 19 COG3086 RseC, Positive regulator of sigma E activity Signal transduction mechanisms 90111173 Common ybiO predicted mechanosensitive channel b0808 140 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 145698254 Common insC KpLE2 phage-like element; IS2 insertion element repressor InsA b1403 39 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 16130243 Common hisQ histidine/lysine/arginine/ornithine transporter subunit b2308 170 COG4215 ArtQ, ABC-type arginine transport system, permease component Amino acid transport and metabolism 145698323 Common yhjK predicted diguanylate cyclase b3529 164 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 16130180 Common yfaU predicted 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase b2245 74 COG3836 HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase Carbohydrate transport and metabolism 16128170 Common yaeT conserved protein b0177 162 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 16130271 Common yfcS predicted periplasmic pilus chaperone b2336 24 COG3121 FimC, P pilus assembly protein, chaperone PapD Cell motility and secretion / Intracellular trafficking and secretion 16128053 Common hepA RNA polymerase-associated helicase protein (ATPase and RNA polymerase recycling factor) b0059 132 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 16128864 Common ycaC predicted hydrolase b0897 77 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 94541137 Common ykgO rpmJ (L36) paralog b4506 61 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 16130922 Common qseC sensory histidine kinase in two-component regulatory system with QseB b3026 214 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 145698335 Common yihP predicted transporter b3877 79 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 16129130 Common ymgC predicted protein b1167 1 None None None 16127995 Nonpathogen thrL thr operon leader peptide b0001 1 None None None 16131882 Common yjbQ conserved protein b4056 126 COG0432 COG0432, Uncharacterized conserved protein Function unknown 16130602 Common yqaB predicted hydrolase b2690 185 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 16131816 Common rplL 50S ribosomal subunit protein L7/L12 b3986 214 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 16131262 Common trpS tryptophanyl-tRNA synthetase b3384 234 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 16128908 Common ycbT predicted fimbrial-like adhesin protein b0941 7 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16131819 Common yjaZ heat shock protein b3989 4 None None None 16132150 Common yjiG conserved inner membrane protein b4329 11 COG0700 SpmB, Uncharacterized membrane protein Function unknown 145698272 Common ydiN predicted transporter b1691 21 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 16129833 Common cheZ chemotaxis regulator, protein phosphatase for CheY b1881 42 COG3143 CheZ, Chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 16129338 Common ompN outer membrane pore protein N, non-specific b1377 31 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 16129083 Common cobB deacetylase of acetyl-CoA synthetase, NAD-dependent b1120 152 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 16130776 Common yqeA predicted amino acid kinase b2874 65 COG0549 ArcC, Carbamate kinase Amino acid transport and metabolism 16131024 Common kbaZ tagatose 6-phosphate aldolase 1, kbaZ subunit b3132 34 COG4573 GatZ, Predicted tagatose 6-phosphate kinase Carbohydrate transport and metabolism 16131010 Common tdcB catabolic threonine dehydratase, PLP-dependent b3117 206 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 16128590 Common uspG universal stress protein UP12 b0607 71 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 90111159 Common ybfE lexA-regulated predicted protein b0685 21 None None None 16129016 Common mdtG predicted drug efflux system b1053 128 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 49176374 Common avtA valine-pyruvate aminotransferase b3572 135 COG3977 COG3977, Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase Amino acid transport and metabolism 90111695 Common yjeM predicted transporter b4156 51 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 90111185 Common ycaO conserved protein b0905 44 COG1944 COG1944, Uncharacterized conserved protein Function unknown 94541111 Common ydbJ predicted protein b4529 10 COG3042 Hlx, Putative hemolysin General function prediction only 16129838 Common tar methyl-accepting chemotaxis protein II b1886 144 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 90111105 Common mmuP CP4-6 prophage; predicted S-methylmethionine transporter b0260 178 COG0833 LysP, Amino acid transporters Amino acid transport and metabolism 16129996 Common wcaD predicted colanic acid polymerase b2056 6 None None None 49176085 Common dsbB oxidoreductase that catalyzes reoxidation of DsbA protein disulfide isomerase I b1185 35 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 16131314 Common yhhZ conserved protein b3442 19 COG3157 Hcp, Hemolysin-coregulated protein (uncharacterized) Function unknown 16130961 Common rpsU 30S ribosomal subunit protein S21 b3065 153 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 90111646 Common ravA fused predicted transcriptional regulator: sigma54 activator protein/conserved protein b3746 92 COG0714 COG0714, MoxR-like ATPases General function prediction only 16128603 Common dpiA DNA-binding response regulator in two-component regulatory system with citA b0620 163 COG4565 CitB, Response regulator of citrate/malate metabolism Transcription / Signal transduction mechanisms 16131773 Common priA Primosome factor n' (replication factor Y) b3935 213 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 16131334 Common ftsX predicted transporter subunit: membrane component of ABC superfamily b3462 112 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 16128914 Common ycbX predicted 2Fe-2S cluster-containing protein b0947 65 COG3217 COG3217, Uncharacterized Fe-S protein General function prediction only 16131985 Common psd phosphatidylserine decarboxylase b4160 97 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 16128504 Common ylbF conserved protein b0520 5 None None None 16131593 Common pstB phosphate transporter subunit b3725 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 16131655 Common hemX predicted uroporphyrinogen III methylase b3803 54 COG2959 HemX, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 16130187 Common ais conserved protein b2252 4 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 16132162 Common yjiS conserved protein b4341 5 COG5457 COG5457, Uncharacterized conserved small protein Function unknown 16129784 Common prc carboxy-terminal protease for penicillin-binding protein 3 b1830 181 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 16128400 Common ribE riboflavin synthase beta chain b0415 229 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 16131594 Common pstA phosphate transporter subunit b3726 226 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 16128271 Common yagT predicted xanthine dehydrogenase, 2Fe-2S subunit b0286 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 16129692 Common chbB N,N'-diacetylchitobiose-specific enzyme IIB component of PTS b1738 29 COG1440 CelA, Phosphotransferase system cellobiose-specific component IIB Carbohydrate transport and metabolism 16132183 Common dnaT DNA biosynthesis protein (primosomal protein I) b4362 8 COG5529 COG5529, Pyocin large subunit General function prediction only 16128559 Common pheP phenylalanine transporter b0576 161 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 16128229 Common proA gamma-glutamylphosphate reductase b0243 189 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 16129694 Common nadE NAD synthetase, NH3/glutamine-dependent b1740 142 COG0171 NadE, NAD synthase Coenzyme metabolism 16130174 Common glpQ periplasmic glycerophosphodiester phosphodiesterase b2239 115 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 16129723 Common ydjE predicted transporter b1769 163 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 16130899 Common yghZ aldo-keto reductase b3001 196 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 16128957 Common ymcE cold shock gene b0991 2 None None None 16128126 Common panC pantothenate synthetase b0133 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 16128850 Common clpA ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity b0882 226 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 90111277 Common ansP L-asparagine transporter b1453 174 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 16129020 Common yceJ predicted cytochrome b561 b1057 91 COG3038 CybB, Cytochrome B561 Energy production and conversion 16131305 Common glgX glycogen debranching enzyme b3431 154 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 145698308 Common ygiB conserved outer membrane protein b3037 21 COG5463 COG5463, Predicted integral membrane protein Function unknown 16128779 Common glnH glutamine transporter subunit b0811 185 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 16131464 Common rhsA rhsA element core protein RshA b3593 65 COG3209 RhsA, Rhs family protein Cell envelope biogenesis, outer membrane 90111466 Common rimM 16S rRNA processing protein b2608 181 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 16129349 Common paaA predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation b1388 46 COG3396 COG3396, Uncharacterized conserved protein Function unknown 16131385 Common mdtE multidrug resistance efflux transporter b3513 165 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 16129786 Common yebS conserved inner membrane protein b1833 54 COG2995 PqiA, Uncharacterized paraquat-inducible protein A Function unknown 16128139 Common sfsA predicted DNA-binding transcriptional regulator b0146 108 COG1489 SfsA, DNA-binding protein, stimulates sugar fermentation General function prediction only 16130197 Common menB dihydroxynaphthoic acid synthetase b2262 178 COG0447 MenB, Dihydroxynaphthoic acid synthase Coenzyme metabolism 16129342 Common ydbH predicted protein b1381 15 None None None 16131732 Common fdoI formate dehydrogenase-O, cytochrome b556 subunit b3892 71 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 90111095 Common cdsA CDP-diglyceride synthase b0175 215 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 16130887 Common pitB phosphate transporter b2987 150 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 16128462 Common ybaL predicted transporter with NAD(P)-binding Rossmann-fold domain b0478 213 COG4651 RosB, Kef-type K+ transport system, predicted NAD-binding component Inorganic ion transport and metabolism 90111457 Common yphH predicted DNA-binding transcriptional regulator b2550 134 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 90111617 Common yiaB conserved inner membrane protein b3563 10 COG4682 COG4682, Predicted membrane protein Function unknown 16129252 Common sapD predicted antimicrobial peptide transporter subunit b1291 249 COG4170 SapD, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 49176435 Common yihO predicted transporter b3876 81 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 16130522 Common aroF 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tyrosine-repressible b2601 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 16128321 Common codB cytosine transporter b0336 69 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 16130299 Common emrY predicted multidrug efflux system b2367 183 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16131486 Common yibD predicted glycosyl transferase b3615 205 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 16131840 Common aceB malate synthase A b4014 83 COG2225 AceB, Malate synthase Energy production and conversion 90111118 Common yaiL nucleoprotein/polynucleotide-associated enzyme b0354 31 COG3122 COG3122, Uncharacterized protein conserved in bacteria Function unknown 16129351 Common paaC predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation b1390 42 COG3396 COG3396, Uncharacterized conserved protein Function unknown 16128887 Common ycbC conserved inner membrane protein b0920 74 COG1434 COG1434, Uncharacterized conserved protein Function unknown 16130036 Common yegT predicted nucleoside transporter b2098 55 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 16130237 Common yfcG predicted glutathione S-transferase b2302 101 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 16128871 Common focA formate transporter b0904 92 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 16131284 Common feoA ferrous iron transporter, protein A b3408 33 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 16128622 Common nadD nicotinic acid mononucleotide adenylyltransferase, NAD(P)-dependent b0639 166 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 16128663 Common seqA regulatory protein for replication initiation b0687 23 COG3057 SeqA, Negative regulator of replication initiationR DNA replication, recombination, and repair 16132215 Common creB DNA-binding response regulator in two-component regulatory system with CreC b4398 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 16130726 Common recC exonuclease V (RecBCD complex), gamma chain b2822 65 COG1330 RecC, Exonuclease V gamma subunit DNA replication, recombination, and repair 16129179 Common chaA calcium/sodium:proton antiporter b1216 48 COG0387 ChaA, Ca2+/H+ antiporter Inorganic ion transport and metabolism 16129194 Common ychJ conserved protein b1233 88 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 16130898 Common yghW predicted protein b2998 8 None None None 16129406 Common ydcZ predicted inner membrane protein b1447 36 COG3238 COG3238, Uncharacterized protein conserved in bacteria Function unknown 16128016 Common insA KpLE2 phage-like element; IS1 repressor protein InsA b0022 14 COG3677 COG3677, Transposase and inactivated derivatives DNA replication, recombination, and repair 16130269 Common yfcQ predicted fimbrial-like adhesin protein b2334 8 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16130977 Common ygjM predicted DNA-binding transcriptional regulator b3082 16 COG5499 COG5499, Predicted transcription regulator containing HTH domain Transcription 16128759 Common ybhQ predicted inner membrane protein b0791 6 None None None 16128954 Common insB IS1 transposase InsAB' b0988 21 COG1662 InsB, Transposase and inactivated derivatives, IS1 family DNA replication, recombination, and repair 16129770 Common yoaE fused predicted membrane protein/conserved protein b1816 214 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 16131458 Common yiaW conserved inner membrane protein b3587 16 None None None 16128874 Common serC 3-phosphoserine/phosphohydroxythreonine aminotransferase b0907 110 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 16128393 Common secD SecYEG protein translocase auxillary subunit b0408 222 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 16131700 Common rdoA Thr/Ser kinase implicated in Cpx stress response b3859 51 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 16128269 Common yagR predicted oxidoreductase with molybdenum-binding domain b0284 119 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 16130357 Common yfeY predicted protein b2432 11 None None None 16131187 Common rplE 50S ribosomal subunit protein L5 b3308 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 16130443 Common ndk multifunctional nucleoside diphosphate kinase and apyrimidinic endonuclease and 3'-phosphodiesterase b2518 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 16130131 Common ccmH heme lyase, CcmH subunit b2194 88 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 16131833 Common zraS sensory histidine kinase in two-component regulatory system with ZraR b4003 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 16129198 Common hns global DNA-binding transcriptional dual regulator H-NS b1237 26 COG2916 Hns, DNA-binding protein H-NS General function prediction only 16131316 Common insA KpLE2 phage-like element; IS1 repressor protein InsA b3444 14 COG3677 COG3677, Transposase and inactivated derivatives DNA replication, recombination, and repair 49176397 Common yieK predicted 6-phosphogluconolactonase b3718 67 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 16131588 Common bglH carbohydrate-specific outer membrane porin, cryptic b3720 22 COG4580 LamB, Maltoporin (phage lambda and maltose receptor) Carbohydrate transport and metabolism 16129168 Common ychH predicted inner membrane protein b1205 10 None None None 16129962 Common hisC histidinol-phosphate aminotransferase b2021 233 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 49176074 Common bssS predicted protein b1060 11 None None None 16129010 Common mdoC membrane protein required for modification of periplasmic glucan b1047 24 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 90111724 Common yjhU KpLE2 phage-like element; predicted DNA-binding transcriptional regulator b4295 68 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 16131220 Common rpsG 30S ribosomal subunit protein S7 b3341 243 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 145698256 Common mdoD glucan biosynthesis protein, periplasmic b1424 50 COG3131 MdoG, Periplasmic glucans biosynthesis protein Inorganic ion transport and metabolism 16128771 Common ybiI conserved protein b0803 24 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 16130081 Common cdd cytidine/deoxycytidine deaminase b2143 43 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 16129858 Common yecA conserved metal-binding protein b1908 88 COG3318 COG3318, Predicted metal-binding protein related to the C-terminal domain of SecA General function prediction only 16131450 Common yiaO predicted transporter b3579 107 COG1638 DctP, TRAP-type C4-dicarboxylate transport system, periplasmic component Carbohydrate transport and metabolism 16129793 Common yebZ predicted inner membrane protein b1840 43 COG1276 PcoD, Putative copper export protein Inorganic ion transport and metabolism 94541093 Common yecJ predicted protein b4537 8 None None None 16128562 Common ybdF conserved protein b0579 37 COG2315 MmcQ, Uncharacterized protein conserved in bacteria Function unknown 16130318 Common fryC predicted enzyme IIC component of PTS b2386 67 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 90111168 Common ybhF fused predicted transporter subunits of ABC superfamily: ATP-binding components b0794 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 16130684 Common ygcF conserved protein b2777 162 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 90111304 Common ynfK predicted dethiobiotin synthetase b1593 141 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 16130686 Common eno enolase b2779 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 16131611 Common asnC DNA-binding transcriptional dual regulator b3743 154 COG1522 Lrp, Transcriptional regulators Transcription 16131337 Common rsmD predicted methyltransferase b3465 205 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 145698313 Common tdcD propionate kinase/acetate kinase C, anaerobic b3115 161 COG0282 ackA, Acetate kinase Energy production and conversion 16130162 Common yfaP conserved protein b2225 13 COG4676 COG4676, Uncharacterized protein conserved in bacteria Function unknown 16130658 Common cysN sulfate adenylyltransferase, subunit 1 b2751 249 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 16131439 Common xylH D-xylose transporter subunit b3568 109 COG4214 XylH, ABC-type xylose transport system, permease component Carbohydrate transport and metabolism 16128879 Common ihfB integration host factor (IHF), DNA-binding protein, beta subunit b0912 203 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 49176045 Common galE UDP-galactose-4-epimerase b0759 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 90111565 Common panF pantothenate:sodium symporter b3258 175 COG4145 PanF, Na+/panthothenate symporter Coenzyme metabolism 16131471 Common mtlD mannitol-1-phosphate dehydrogenase, NAD(P)-binding b3600 90 COG0246 MtlD, Mannitol-1-phosphate/altronate dehydrogenases Carbohydrate transport and metabolism 145698268 Common rstA DNA-binding response regulator in two-component regulatory system with RstB b1608 218 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 16129854 Common yecR predicted protein b1904 5 None None None 145698266 Common ynfF oxidoreductase subunit b1588 184 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 16131712 Common yihL predicted DNA-binding transcriptional regulator b3872 65 COG2188 PhnF, Transcriptional regulators Transcription 90111476 Common csiD predicted protein b2659 12 None None None 90111351 Common cutC copper homeostasis protein b1874 59 COG3142 CutC, Uncharacterized protein involved in copper resistance Inorganic ion transport and metabolism 90111663 Common yiiF conserved protein b3890 10 None None None 90111083 Common leuO DNA-binding transcriptional activator b0076 123 COG0583 LysR, Transcriptional regulator Transcription 16128055 Common araD L-ribulose-5-phosphate 4-epimerase b0061 112 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 16130245 Common argT lysine/arginine/ornithine transporter subunit b2310 176 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 90111739 Common yjiY predicted inner membrane protein b4354 105 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 16128843 Common aqpZ aquaporin b0875 98 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 16128135 Common folK 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase b0142 202 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 16128675 Common ybfA predicted protein b0699 11 None None None 16130959 Common ttdT predicted tartrate:succinate antiporter b3063 73 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 90111323 Common ynjB conserved protein b1754 28 COG4134 COG4134, ABC-type uncharacterized transport system, periplasmic component General function prediction only 90111445 Common hyfC hydrogenase 4, membrane subunit b2483 80 COG0650 HyfC, Formate hydrogenlyase subunit 4 Energy production and conversion 16128454 Common dnaX DNA polymerase III/DNA elongation factor III, tau and gamma subunits b0470 248 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 16130831 Common yggF predicted hexoseP phosphatase b2930 112 COG1494 GlpX, Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins Carbohydrate transport and metabolism 16130094 Common lysP lysine transporter b2156 169 COG0833 LysP, Amino acid transporters Amino acid transport and metabolism 16130920 Common ygiW conserved protein b3024 26 COG3111 COG3111, Uncharacterized conserved protein Function unknown 16128943 Common hyaF protein involved in nickel incorporation into hydrogenase-1 proteins b0977 19 None None None 90111671 Common murI glutamate racemase b3967 189 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 94541125 Common yheV predicted protein b4551 21 COG3529 COG3529, Predicted nucleic-acid-binding protein containing a Zn-ribbon domain General function prediction only 16128862 Common dmsB dimethyl sulfoxide reductase, anaerobic, subunit B b0895 164 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 16128925 Common sulA SOS cell division inhibitor b0958 10 COG5404 SulA, SOS-response cell division inhibitor, blocks FtsZ ring formation Cell division and chromosome partitioning 16128164 Common pyrH uridylate kinase b0171 237 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 16130476 Common glyA serine hydroxymethyltransferase b2551 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 16129777 Common cspC stress protein, member of the CspA-family b1823 181 COG1278 CspC, Cold shock proteins Transcription 90111207 Common ymdC predicted hydrolase b1046 147 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 16130877 Common glcG conserved protein b2977 66 COG3193 GlcG, Uncharacterized protein, possibly involved in utilization of glycolate and propanediol General function prediction only 16130251 Common accD acetyl-CoA carboxylase, beta (carboxyltranferase) subunit b2316 219 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 16131324 Common ugpA glycerol-3-phosphate transporter subunit b3452 150 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 90111602 Common arsB arsenite/antimonite transporter b3502 108 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 16131995 Common hflX predicted GTPase b4173 232 COG2262 HflX, GTPases General function prediction only 16130336 Common yfeH predicted inner membrane protein b2410 59 COG0385 COG0385, Predicted Na+-dependent transporter General function prediction only 16128045 Common ksgA S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase b0051 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 16130007 Common yegE predicted diguanylate cyclase, GGDEF domain signalling protein b2067 191 COG3447 COG3447, Predicted integral membrane sensor domain Signal transduction mechanisms 16130142 Common napG ferredoxin-type protein essential for electron transfer from ubiquinol to periplasmic nitrate reductase (NapAB) b2205 65 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 90111125 Common yaiZ predicted inner membrane protein b0380 6 None None None 16128217 Common dinB DNA polymerase IV b0231 183 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 90111746 Common nadR bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase b4390 31 COG3172 NadR, Predicted ATPase/kinase involved in NAD metabolism Coenzyme metabolism 16129481 Common yneF predicted diguanylate cyclase b1522 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 16132108 Common fecE KpLE2 phage-like element; iron-dicitrate transporter subunit b4287 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 16129235 Common topA DNA topoisomerase I, omega subunit b1274 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 90111374 Common hisA N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'-phosphoribosyl)-4-imidazolecarboxamide isomerase b2024 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 90111082 Common leuB 3-isopropylmalate dehydrogenase b0073 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 90111137 Common ybaO predicted DNA-binding transcriptional regulator b0447 152 COG1522 Lrp, Transcriptional regulators Transcription 90111117 Common mhpT predicted 3-hydroxyphenylpropionic transporter b0353 148 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16128580 Common ybdB conserved protein b0597 71 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 16131663 Common xerC site-specific tyrosine recombinase b3811 228 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 16131507 Common rpmG 50S ribosomal subunit protein L33 b3636 137 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 90111384 Common gatY D-tagatose 1,6-bisphosphate aldolase 2, catalytic subunit b2096 178 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 16130711 Common fucU L-fucose mutarotase b2804 31 COG4154 FucU, Fucose dissimilation pathway protein FucU Carbohydrate transport and metabolism 16130818 Common scpA methylmalonyl-CoA mutase b2917 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 16130597 Common emrA multidrug efflux system b2685 149 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 16130429 Common yfgG predicted protein b2504 6 None None None 16129185 Common narX sensory histidine kinase in two-component regulatory system with NarL b1222 148 COG3850 NarQ, Signal transduction histidine kinase, nitrate/nitrite-specific Signal transduction mechanisms 16131408 Common bcsE conserved protein b3536 16 None None None 16130147 Common mqo malate dehydrogenase, FAD/NAD(P)-binding domain b2210 57 COG0579 COG0579, Predicted dehydrogenase General function prediction only 16131119 Common sspA stringent starvation protein A b3229 111 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 16128997 Common ycdX predicted zinc-binding hydrolase b1034 52 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 49176236 Common yfhR predicted peptidase b2534 101 COG1073 COG1073, Hydrolases of the alpha/beta superfamily General function prediction only 16132197 Common yjjI conserved protein b4380 14 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 16130598 Common emrB multidrug efflux system protein b2686 201 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16132003 Common yjfI conserved protein b4181 13 COG3789 COG3789, Uncharacterized protein conserved in bacteria Function unknown 16130050 Common yehE predicted protein b2112 4 None None None 90111434 Common yfeZ predicted inner membrane protein b2433 11 None None None 16130274 Common fadJ fused enoyl-CoA hydratase and epimerase and isomerase/3-hydroxyacyl-CoA dehydrogenase b2341 166 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 16131140 Common csrD conserved inner membrane protein b3252 151 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 145698320 Common yhiM conserved inner membrane protein b3491 5 None None None 16130192 Common arnT 4-amino-4-deoxy-L-arabinose transferase b2257 81 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 16131857 Common xylE D-xylose transporter b4031 103 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 16128270 Common yagS predicted oxidoreductase with FAD-binding domain b0285 75 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 90111311 Common ydhJ undecaprenyl pyrophosphate phosphatase b1644 169 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 16130116 Common yejB predicted oligopeptide transporter subunit b2178 219 COG4174 COG4174, ABC-type uncharacterized transport system, permease component General function prediction only 90111286 Common ydeN conserved protein b1498 91 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 16131311 Common yhhW predicted protein b3439 146 COG1741 COG1741, Pirin-related protein General function prediction only 49176426 Common ubiE bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase/ S-adenosylmethionine:2-DMK methyltransferase b3833 222 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 16128414 Common cyoD cytochrome o ubiquinol oxidase subunit IV b0429 61 COG3125 CyoD, Heme/copper-type cytochrome/quinol oxidase, subunit 4 Energy production and conversion 16130302 Common evgS hybrid sensory histidine kinase in two-component regulatory system with EvgA b2370 216 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 16129496 Common ydeJ conserved protein b1537 168 COG1546 CinA, Uncharacterized protein (competence- and mitomycin-induced) General function prediction only 16130046 Common yehA predicted fimbrial-like adhesin protein b2108 3 None None None 145698310 Common ygjG putrescine:2-oxoglutaric acid aminotransferase, PLP-dependent b3073 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 16131375 Common arsC arsenate reductase b3503 110 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 16131122 Common yhcM conserved protein with nucleoside triphosphate hydrolase domain b3232 103 COG1485 COG1485, Predicted ATPase General function prediction only 16128800 Common gsiD predicted peptide transporter subunit: membrane component of ABC superfamily b0832 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 16131632 Common ilvC ketol-acid reductoisomerase, NAD(P)-binding b3774 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 16129389 Common tehB predicted S-adenosyl-L-methionine-dependent methyltransferase b1430 56 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 16129548 Common ynfH oxidoreductase, membrane subunit b1590 27 COG3302 DmsC, DMSO reductase anchor subunit General function prediction only 16128103 Common ampD N-acetyl-anhydromuranmyl-L-alanine amidase b0110 108 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 16128749 Common moaA molybdopterin biosynthesis protein A b0781 202 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 16131519 Common gmk guanylate kinase b3648 214 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 16128117 Common gcd glucose dehydrogenase b0124 60 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 90111394 Common yohC predicted inner membrane protein b2135 24 None None None 16130103 Common yeiN conserved protein b2165 49 COG2313 IndA, Uncharacterized enzyme involved in pigment biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 90111539 Common yqjF predicted quinol oxidase subunit b3101 37 COG2259 COG2259, Predicted membrane protein Function unknown 16128742 Common bioA 7,8-diaminopelargonic acid synthase, PLP-dependent b0774 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 16129072 Common ndh respiratory NADH dehydrogenase 2/cupric reductase b1109 214 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 16131497 Common rfaJ UDP-D-glucose:(galactosyl)lipopolysaccharide glucosyltransferase b3626 29 COG1442 RfaJ, Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases Cell envelope biogenesis, outer membrane 16131806 Common murB UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding b3972 203 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 16128982 Common ycdO conserved protein b1018 27 COG2822 COG2822, Predicted periplasmic lipoprotein involved in iron transport Inorganic ion transport and metabolism 16131824 Common thiC thiamin (pyrimidine moiety) biosynthesis protein b3994 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 16130350 Common cysP thiosulfate transporter subunit b2425 88 COG4150 CysP, ABC-type sulfate transport system, periplasmic component Inorganic ion transport and metabolism 16128938 Common hyaA hydrogenase 1, small subunit b0972 77 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 90111533 Common folB bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase b3058 55 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 16129875 Common yedD predicted protein b1928 7 None None None 16128302 Common yahC predicted inner membrane protein b0317 18 None None None 16129176 Common ychQ predicted transcriptional regulator b1213 33 COG3094 COG3094, Uncharacterized protein conserved in bacteria Function unknown 16131850 Common lysC aspartokinase III b4024 234 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 16130204 Common elaD predicted enzyme b2269 2 COG5160 ULP1, Protease, Ulp1 family Posttranslational modification, protein turnover, chaperones 16130888 Common gsp fused glutathionylspermidine amidase/glutathionylspermidine synthetase b2988 52 COG0754 Gsp, Glutathionylspermidine synthase Amino acid transport and metabolism 16128153 Common dgt deoxyguanosine triphosphate triphosphohydrolase b0160 160 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 16129159 Common ycgY predicted protein b1196 2 None None None 16131956 Common yjdL predicted transporter b4130 81 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 16128855 Common trxB thioredoxin reductase, FAD/NAD(P)-binding b0888 247 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 16129759 Common fadD acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase) b1805 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 16128092 Common mutT nucleoside triphosphate pyrophosphohydrolase, marked preference for dGTP b0099 158 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 49176088 Common ldrB toxic polypeptide, small b4421 3 None None None 16131476 Common lldD L-lactate dehydrogenase, FMN-linked b3605 133 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 16130827 Common pgk phosphoglycerate kinase b2926 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 94541105 Common ymgF predicted protein b4520 1 None None None 90111272 Common ydcO predicted benzoate transporter b1433 59 COG3135 BenE, Uncharacterized protein involved in benzoate metabolism Secondary metabolites biosynthesis, transport, and catabolism 16129668 Common ihfA integration host factor (IHF), DNA-binding protein, alpha subunit b1712 210 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 16130462 Common hcaR DNA-binding transcriptional activator of 3-phenylpropionic acid catabolism b2537 189 COG0583 LysR, Transcriptional regulator Transcription 16128362 Common sbmA predicted transporter b0377 57 COG1133 SbmA, ABC-type long-chain fatty acid transport system, fused permease and ATPase components Lipid metabolism 145698286 Nonpathogen ypaB hypothetical protein b4605 1 None None None 16130309 Common yfdY predicted inner membrane protein b2377 3 None None None 16132071 Common yjgI predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain b4249 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 16130633 Common hypA protein involved in nickel insertion into hydrogenases 3 b2726 85 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 16131795 Common argE acetylornithine deacetylase b3957 200 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 16130734 Common nudH nucleotide hydrolase b2830 115 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 16129633 Common lpp murein lipoprotein b1677 19 COG4238 COG4238, Murein lipoprotein Cell envelope biogenesis, outer membrane 16129864 Common yecC predicted transporter subunit: ATP-binding component of ABC superfamily b1917 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 16130916 Common ygiS predicted transporter subunit: periplasmic-binding component of ABC superfamily b3020 204 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 90111146 Common ybcJ predicted RNA-binding protein b0528 32 COG2501 COG2501, Uncharacterized conserved protein Function unknown 16129638 Common sufC component of SufBCD complex, ATP-binding component of ABC superfamily b1682 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 16130347 Common cysM cysteine synthase B (O-acetylserine sulfhydrolase B) b2421 230 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 16130157 Common atoC fused response regulator of ato operon, in two-component system with AtoS: response regulator/sigma54 interaction protein b2220 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 16131359 Common yhiI predicted HlyD family secretion protein b3487 133 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 16130169 Common nrdA ribonucleoside diphosphate reductase 1, alpha subunit b2234 207 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 145698274 Common yniD predicted protein b4535 3 None None None 16129064 Common ptsG fused glucose-specific PTS enzymes: IIB component/IIC component b1101 49 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 90111309 Common ydhA predicted lipoprotein b1639 11 COG3895 COG3895, Predicted periplasmic protein General function prediction only 90111416 Common yfcC predicted inner membrane protein b2298 44 COG1288 COG1288, Predicted membrane protein Function unknown 90111634 Common emrD multidrug efflux system protein b3673 145 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16128402 Common thiL thiamin-monophosphate kinase b0417 195 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 16128249 Common insB IS1 transposase InsAB' b0264 21 COG1662 InsB, Transposase and inactivated derivatives, IS1 family DNA replication, recombination, and repair 16128963 Common torA trimethylamine N-oxide (TMAO) reductase I, catalytic subunit b0997 169 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 145698227 Common sfmH predicted fimbrial-like adhesin protein b0533 5 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16129079 Common lolC outer membrane-specific lipoprotein transporter subunit b1116 155 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 16128254 Common yagF CP4-6 prophage; predicted dehydratase b0269 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 16128965 Common cbpM modulator of CbpA co-chaperone b0999 18 None None None 16130547 Nonpathogen yfjM CP4-57 prophage; predicted protein b2629 1 None None None 16131060 Common infB fused protein chain initiation factor 2, IF2: membrane protein/conserved protein b3168 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 49176356 Common gntR DNA-binding transcriptional repressor b3438 127 COG1609 PurR, Transcriptional regulators Transcription 16128038 Common fixX predicted 4Fe-4S ferredoxin-type protein b0044 35 COG2440 FixX, Ferredoxin-like protein Energy production and conversion 16130642 Common ygbI predicted DNA-binding transcriptional regulator b2735 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 90111732 Common kptA 2'-phosphotransferase b4331 44 COG1859 KptA, RNA:NAD 2'-phosphotransferase Translation, ribosomal structure and biogenesis 16130262 Common yfcA conserved inner membrane protein b2327 147 COG0730 COG0730, Predicted permeases General function prediction only 16128119 Common can carbonic anhydrase b0126 117 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 16130151 Common apbE predicted thiamine biosynthesis lipoprotein b2214 138 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 16130830 Common yggD predicted DNA-binding transcriptional regulator b2929 16 COG3722 MtlR, Transcriptional regulator Transcription 16129090 Common pepT peptidase T b1127 61 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 145698290 Common nuoG NADH:ubiquinone oxidoreductase, chain G b2283 188 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 16130704 Common sdaB L-serine deaminase II b2797 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 90111347 Common yebB predicted protein b1862 8 None None None 16131085 Common yrbF predicted toluene transporter subunit: ATP-binding component of ABC superfamily b3195 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 16131570 Common dnaA chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator b3702 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 16128398 Common nrdR conserved protein b0413 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 16131206 Common gspF general secretory pathway component, cryptic b3327 144 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 16130027 Common insE IS3 element protein InsE b2088 32 None None None 16131880 Common tyrB tyrosine aminotransferase, tyrosine-repressible, PLP-dependent b4054 83 COG1448 TyrB, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 16132157 Common yjiN conserved inner membrane protein b4336 49 COG2733 COG2733, Predicted membrane protein Function unknown 16128540 Common borD DLP12 prophage; predicted lipoprotein b0557 6 None None None 16128553 Common cusS sensory histidine kinase in two-component regulatory system with CusR, senses copper ions b0570 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 16131457 Common yiaV membrane fusion protein (MFP) component of efflux pump, signal anchor b3586 133 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 16128206 Common ivy inhibitor of vertebrate C-lysozyme b0220 7 None None None 16128278 Common matB conserved protein b0293 5 None None None 16129904 Common yedI conserved inner membrane protein b1958 61 COG2354 COG2354, Uncharacterized protein conserved in bacteria Function unknown 16131009 Common tdcC L-threonine/L-serine transporter b3116 33 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 90111594 Common livF leucine/isoleucine/valine transporter subunit b3454 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 145698299 Nonpathogen ypfM hypothetical protein b4606 1 None None None 16132128 Common yjhQ KpLE2 phage-like element; predicted acetyltransferase b4307 85 COG3153 COG3153, Predicted acetyltransferase General function prediction only 90111451 Common sseA 3-mercaptopyruvate sulfurtransferase b2521 144 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 16128847 Common macB fused macrolide transporter subunits of ABC superfamily: ATP-binding component/membrane component b0879 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 145698248 Common ychO predicted invasin b1220 14 None None None 145698344 Common insC KpLE2 phage-like element; IS2 insertion element repressor InsA b4272 39 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 16128001 Common yaaJ predicted transporter b0007 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 16128751 Common moaC molybdopterin biosynthesis, protein C b0783 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 90111333 Common yeaO conserved protein b1792 77 COG3189 COG3189, Uncharacterized conserved protein Function unknown 16130380 Common eutE predicted aldehyde dehydrogenase, ethanolamine utilization protein b2455 174 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 16128523 Common insE IS3 element protein InsE b0540 32 None None None 16131022 Common yhaV conserved protein b3130 21 None None None 16130987 Common uxaC uronate isomerase b3092 59 COG1904 UxaC, Glucuronate isomerase Carbohydrate transport and metabolism 16128728 Common modF fused molybdate transporter subunits of ABC superfamily: ATP-binding components b0760 249 COG1119 ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA Inorganic ion transport and metabolism 16131319 Common ggt gamma-glutamyltranspeptidase b3447 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 16129232 Common yciK predicted oxoacyl-(acyl carrier protein) reductase, EmrKY-TolC system b1271 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 16130177 Common glpB sn-glycerol-3-phosphate dehydrogenase (anaerobic), membrane anchor subunit b2242 32 COG3075 GlpB, Anaerobic glycerol-3-phosphate dehydrogenase Amino acid transport and metabolism 16128955 Common cspH stress protein, member of the CspA-family b0989 43 COG1278 CspC, Cold shock proteins Transcription 16130924 Common mdaB NADPH quinone reductase b3028 49 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 90111183 Common dmsA dimethyl sulfoxide reductase, anaerobic, subunit A b0894 184 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 16131984 Common yjeP predicted mechanosensitive channel b4159 184 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 16131770 Common hslV peptidase component of the HslUV protease b3932 149 COG5405 HslV, ATP-dependent protease HslVU (ClpYQ), peptidase subunit Posttranslational modification, protein turnover, chaperones 16128048 Common imp exported protein required for envelope biosynthesis and integrity b0054 119 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 16129972 Common wbbK lipopolysaccharide biosynthesis protein b2032 28 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 145698300 Common yphA predicted inner membrane protein b2543 54 COG2259 COG2259, Predicted membrane protein Function unknown 16128163 Common tsf protein chain elongation factor EF-Ts b0170 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 16128280 Common ykgL predicted protein b0295 1 None None None 90111589 Common gntX gluconate periplasmic binding protein with phosphoribosyltransferase domain, GNT I system b3413 157 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 16130465 Common hcaC 3-phenylpropionate dioxygenase, predicted ferredoxin subunit b2540 87 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 16128193 Common gmhB D,D-heptose 1,7-bisphosphate phosphatase b0200 132 COG0241 HisB, Histidinol phosphatase and related phosphatases Amino acid transport and metabolism 16131191 Common rpmC 50S ribosomal subunit protein L29 b3312 95 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 16132062 Common treB fused trehalose(maltose)-specific PTS enzyme: IIB component/IIC component b4240 42 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 16131925 Common phnI carbon-phosphorus lyase complex subunit b4099 45 COG3626 PhnI, Uncharacterized enzyme of phosphonate metabolism Inorganic ion transport and metabolism 90111628 Common ligB DNA ligase, NAD(+)-dependent b3647 217 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 16128041 Common kefC potassium:proton antiporter b0047 196 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 145698255 Common hrpA ATP-dependent helicase b1413 132 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 16130172 Common inaA conserved protein b2237 7 None None None 16131893 Common actP acetate transporter b4067 161 COG4147 DhlC, Predicted symporter General function prediction only 16131503 Common rfaQ lipopolysaccharide core biosynthesis protein b3632 106 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 16131810 Common tufB protein chain elongation factor EF-Tu (duplicate of tufA) b3980 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 16130170 Common nrdB ribonucleoside diphosphate reductase 1, beta subunit, ferritin-like protein b2235 154 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 16130091 Common folE GTP cyclohydrolase I b2153 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 16128019 Common ribF bifunctional riboflavin kinase/FAD synthetase b0025 211 COG0196 RibF, FAD synthase Coenzyme metabolism 16129422 Common nhoA N-hydroxyarylamine O-acetyltransferase b1463 45 COG2162 NhoA, Arylamine N-acetyltransferase Secondary metabolites biosynthesis, transport, and catabolism 16129216 Common yciC predicted inner membrane protein b1255 15 None None None 16129871 Common fliD flagellar filament capping protein b1924 97 COG1345 FliD, Flagellar capping protein Cell motility and secretion 94541119 Common yfbW conserved protein b4544 12 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 49176437 Common yihR predicted aldose-1-epimerase b3879 52 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 16131591 Common bglG transcriptional antiterminator of the bgl operon b3723 29 COG3711 BglG, Transcriptional antiterminator Transcription 16132082 Common pepA aminopeptidase A, a cyteinylglycinase b4260 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 16129321 Common ydaV Rac prophage; predicted DNA replication protein b1360 26 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 16128777 Common glnQ glutamine transporter subunit b0809 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 16132021 Common yjfY predicted protein b4199 8 None None None 16131231 Common yheS fused predicted transporter subunits of ABC superfamily: ATP-binding components b3352 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 16131268 Common hofQ predicted fimbrial transporter b3391 142 COG4796 HofQ, Type II secretory pathway, component HofQ Intracellular trafficking and secretion 16129895 Common fliP flagellar biosynthesis protein b1948 128 COG1338 FliP, Flagellar biosynthesis pathway, component FliP Cell motility and secretion / Intracellular trafficking and secretion 16129898 Common rcsA DNA-binding transcriptional activator, co-regulator with RcsB b1951 10 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 16128189 Common rcsF predicted outer membrane protein, signal b0196 13 None None None 16131078 Common sfsB DNA-binding transcriptional activator of maltose metabolism b3188 22 COG3423 Nlp, Predicted transcriptional regulator Transcription 16129630 Common ydhY predicted 4Fe-4S ferridoxin-type protein b1674 153 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 16129720 Common sppA protease IV (signal peptide peptidase) b1766 189 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 90111241 Common yciH conserved protein b1282 50 COG0023 SUI1, Translation initiation factor 1 (eIF-1/SUI1) and related proteins Translation, ribosomal structure and biogenesis 16128906 Common ycbR predicted periplasmic pilin chaperone b0939 25 COG3121 FimC, P pilus assembly protein, chaperone PapD Cell motility and secretion / Intracellular trafficking and secretion 16130868 Common yghD predicted secretion pathway M-type protein, membrane anchored b2968 19 COG3149 PulM, Type II secretory pathway, component PulM Intracellular trafficking and secretion 49176282 Common ygfA predicted ligase b2912 187 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 16130858 Common ansB periplasmic L-asparaginase II b2957 140 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 16128640 Common lnt apolipoprotein N-acyltransferase b0657 165 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 16131701 Common dsbA periplasmic protein disulfide isomerase I b3860 67 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 162135903 Common yebN conserved inner membrane protein b1821 67 COG1971 COG1971, Predicted membrane protein Function unknown 16129581 Common add adenosine deaminase b1623 109 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 16131411 Common yhjV predicted transporter b3539 32 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 16129376 Common aldA aldehyde dehydrogenase A, NAD-linked b1415 221 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 49176480 Common yjgN conserved inner membrane protein b4257 28 COG4269 COG4269, Predicted membrane protein Function unknown 16130266 Common yfcN conserved protein b2331 71 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 90111560 Common yhcB conserved protein b3233 22 COG3105 COG3105, Uncharacterized protein conserved in bacteria Function unknown 16128516 Common sfmD predicted outer membrane export usher protein b0532 32 COG3188 FimD, P pilus assembly protein, porin PapC Cell motility and secretion / Intracellular trafficking and secretion 90111743 Common yjjP predicted inner membrane protein b4364 53 COG2966 COG2966, Uncharacterized conserved protein Function unknown 16130783 Common xdhD fused predicted xanthine/hypoxanthine oxidase: molybdopterin-binding subunit/Fe-S binding subunit b2881 111 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 16130967 Common aer fused signal transducer for aerotaxis sensory component/methyl accepting chemotaxis component b3072 161 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 16130585 Common ygaC predicted protein b2671 8 None None None 16131096 Common npr phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) b3206 129 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 16131247 Common yhfL conserved secreted peptide b3369 6 None None None 16131477 Common yibK predicted rRNA methylase b3606 163 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 16129540 Common ynfA conserved inner membrane protein b1582 80 COG1742 COG1742, Uncharacterized conserved protein Function unknown 16131498 Common rfaI UDP-D-galactose:(glucosyl)lipopolysaccharide-alpha-1,3-D-galactosyltransferase b3627 30 COG1442 RfaJ, Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases Cell envelope biogenesis, outer membrane 16131624 Common yifE conserved protein b3764 23 COG3085 COG3085, Uncharacterized protein conserved in bacteria Function unknown 16128510 Common cysS cysteinyl-tRNA synthetase b0526 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 16129547 Common ynfG oxidoreductase, Fe-S subunit b1589 164 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 16131775 Common yiiX predicted peptidoglycan peptidase b3937 10 COG3863 COG3863, Uncharacterized distant relative of cell wall-associated hydrolases Function unknown 90111509 Common ygfT fused predicted oxidoreductase: Fe-S subunit/nucleotide-binding subunit b2887 211 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 16128531 Common ninE DLP12 prophage; conserved protein b0548 2 None None None 16131513 Common pyrE orotate phosphoribosyltransferase b3642 159 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 16131109 Common yhcF predicted transcriptional regulator b3219 7 None None None 16129446 Common ddpA D-ala-D-a la transporter subunit b1487 207 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 16132018 Common ulaD 3-keto-L-gulonate 6-phosphate decarboxylase b4196 53 COG0269 SgbH, 3-hexulose-6-phosphate synthase and related proteins Carbohydrate transport and metabolism 16131330 Common livK leucine transporter subunit b3458 144 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 16130879 Common glcD glycolate oxidase subunit, FAD-linked b2979 201 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 16128230 Common ykfI CP4-6 prophage; toxin of the YkfI-YafW toxin-antitoxin system b0245 8 None None None 16129918 Common yedZ conserved inner membrane protein b1972 78 COG2717 COG2717, Predicted membrane protein Function unknown 16128371 Common proC pyrroline-5-carboxylate reductase, NAD(P)-binding b0386 215 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 16131102 Common gltB glutamate synthase, large subunit b3212 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 16129277 Common ycjT predicted hydrolase b1316 50 COG1554 ATH1, Trehalose and maltose hydrolases (possible phosphorylases) Carbohydrate transport and metabolism 16129995 Common wcaE predicted glycosyl transferase b2055 59 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 90111658 Common yihS predicted glucosamine isomerase b3880 36 COG2942 COG2942, N-acyl-D-glucosamine 2-epimerase Carbohydrate transport and metabolism 16128980 Common putA fused DNA-binding transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase b1014 220 COG4230 COG4230, Delta 1-pyrroline-5-carboxylate dehydrogenase Energy production and conversion 16131036 Common yraJ predicted outer membrane protein b3144 35 COG3188 FimD, P pilus assembly protein, porin PapC Cell motility and secretion / Intracellular trafficking and secretion 16132134 Common fimE tyrosine recombinase/inversion of on/off regulator of fimA b4313 212 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 49176329 Common nanR DNA-binding transcriptional dual regulator b3226 127 COG2186 FadR, Transcriptional regulators Transcription 16131859 Common malF maltose transporter subunit b4033 143 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 16132113 Common fecR KpLE2 phage-like element; transmembrane signal transducer for ferric citrate transport b4292 45 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 16128709 Common cydB cytochrome d terminal oxidase, subunit II b0734 156 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 16128008 Common dnaK chaperone Hsp70, co-chaperone with DnaJ b0014 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 16131165 Common smg conserved protein b3284 40 COG2922 Smg, Uncharacterized protein conserved in bacteria Function unknown 16131349 Common nikB nickel transporter subunit b3477 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 16128891 Common mukB fused chromosome partitioning protein: predicted nucleotide hydrolase/conserved protein/conserved protein b0924 30 COG3096 MukB, Uncharacterized protein involved in chromosome partitioning Cell division and chromosome partitioning 16130179 Common yfaD conserved protein b2244 27 COG5464 COG5464, Uncharacterized conserved protein Function unknown 16131852 Nonpathogen yjbE predicted protein b4026 1 None None None 49176247 Common recN recombination and repair protein b2616 201 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 16130418 Common yfgO predicted inner membrane protein b2493 136 COG0628 PerM, Predicted permease General function prediction only 16128571 Common fepC iron-enterobactin transporter subunit b0588 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 16129691 Common chbC N,N'-diacetylchitobiose-specific enzyme IIC component of PTS b1737 38 COG1455 CelB, Phosphotransferase system cellobiose-specific component IIC Carbohydrate transport and metabolism 16129331 Common insH IS5 transposase and trans-activator b1370 37 COG3039 COG3039, Transposase and inactivated derivatives, IS5 family DNA replication, recombination, and repair 16128211 Common yafQ predicted toxin of the YafQ-DinJ toxin-antitoxin system b0225 34 COG3041 COG3041, Uncharacterized protein conserved in bacteria Function unknown 16130186 Common nudI predicted NUDIX hydrolase b2251 5 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 145698329 Nonpathogen tisB lexA-regulated toxic peptide b4618 1 None None None 16128176 Common rnhB ribonuclease HII, degrades RNA of DNA-RNA hybrids b0183 239 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 90111549 Common yhbV predicted protease b3159 49 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 16131228 Common slyD FKBP-type peptidyl prolyl cis-trans isomerase (rotamase) b3349 125 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 90111249 Common ycjG L-Ala-D/L-Glu epimerase b1325 105 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 16130255 Common pdxB erythronate-4-phosphate dehydrogenase b2320 228 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 16130773 Common ygeX 2,3-diaminopropionate ammonia-lyase b2871 92 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 16129294 Common uspE stress-induced protein b1333 52 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 16129284 Common tyrR DNA-binding transcriptional dual regulator, tyrosine-binding b1323 172 COG3283 TyrR, Transcriptional regulator of aromatic amino acids metabolism Transcription / Amino acid transport and metabolism 16129304 Common dbpA ATP-dependent RNA helicase, specific for 23S rRNA b1343 238 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 16128672 Common kdpC potassium translocating ATPase, subunit C b0696 95 COG2156 KdpC, K+-transporting ATPase, c chain Inorganic ion transport and metabolism 16128635 Common gltL glutamate and aspartate transporter subunit b0652 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 16129345 Common feaR DNA-binding transcriptional dual regulator b1384 81 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16128808 Common deoR DNA-binding transcriptional repressor b0840 111 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 16129596 Common pdxH pyridoxine 5'-phosphate oxidase b1638 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 16128089 Common lpxC UDP-3-O-acyl N-acetylglucosamine deacetylase b0096 139 COG0774 LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase Cell envelope biogenesis, outer membrane 16129040 Common flgF flagellar component of cell-proximal portion of basal-body rod b1077 121 COG4787 FlgF, Flagellar basal body rod protein Cell motility and secretion 90111098 Common yaeF predicted lipoprotein b0193 5 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 16130951 Common htrG predicted signal transduction protein (SH3 domain) b3055 32 COG3103 COG3103, SH3 domain protein Signal transduction mechanisms 16131617 Common rbsA fused D-ribose transporter subunits of ABC superfamily: ATP-binding components b3749 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 145698319 Common yhhJ predicted transporter subunit: membrane component of ABC superfamily b3485 110 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 16131203 Common gspC general secretory pathway component, cryptic b3324 11 COG3031 PulC, Type II secretory pathway, component PulC Intracellular trafficking and secretion 16131902 Common nrfG heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfG b4076 47 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 90111196 Common yccU predicted CoA-binding protein with NAD(P)-binding Rossmann-fold domain b0965 133 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 16129848 Common otsA trehalose-6-phosphate synthase b1896 97 COG0380 OtsA, Trehalose-6-phosphate synthase Carbohydrate transport and metabolism 16128593 Common rnk regulator of nucleoside diphosphate kinase b0610 75 COG0782 GreA, Transcription elongation factor Transcription 16129521 Common hokD Qin prophage; small toxic polypeptide b1562 7 None None None 90111702 Common ulaG predicted L-ascorbate 6-phosphate lactonase b4192 26 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 49176137 Common rpmI 50S ribosomal subunit protein L35 b1717 24 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 16128073 Common fruR DNA-binding transcriptional dual regulator b0080 122 COG1609 PurR, Transcriptional regulators Transcription 90111693 Common sugE multidrug efflux system protein b4148 122 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 16128076 Common ftsL membrane bound cell division protein at septum containing leucine zipper motif b0083 25 COG3116 FtsL, Cell division protein Cell division and chromosome partitioning 16130848 Common gshB glutathione synthetase b2947 124 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 16131947 Common yjdF conserved inner membrane protein b4121 40 COG3647 COG3647, Predicted membrane protein Function unknown 16129177 Common ychA predicted transcriptional regulator b1214 51 COG2912 COG2912, Uncharacterized conserved protein Function unknown 16129018 Common yceA conserved protein b1055 137 COG1054 COG1054, Predicted sulfurtransferase General function prediction only 16128427 Common ybaV conserved protein b0442 79 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 16131084 Common yrbE predicted toluene transporter subunit: membrane component of ABC superfamily b3194 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 16131474 Common lldP L-lactate permease b3603 102 COG1620 LldP, L-lactate permease Energy production and conversion 90111707 Common ytfK conserved protein b4217 14 None None None 16128899 Common pepN aminopeptidase N b0932 160 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 16129642 Common ydiI conserved protein b1686 84 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 16131469 Common yibI predicted inner membrane protein b3598 15 None None None 49176474 Common ytfI predicted protein b4215 2 None None None 90111359 Common yodD predicted protein b1953 6 None None None 16129474 Common lsrD AI2 transporter b1515 100 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 16129587 Common rsxC fused predicted 4Fe-4S ferredoxin-type protein/conserved protein b1629 99 COG4656 RnfC, Predicted NADH:ubiquinone oxidoreductase, subunit RnfC Energy production and conversion 145698312 Common yhaO predicted transporter b3110 32 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 49176035 Common hokE toxic polypeptide, small b4415 4 None None None 16130897 Common hybO hydrogenase 2, small subunit b2997 77 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 16131653 Common aslA acrylsulfatase-like enzyme b3801 68 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 16129945 Common yeeU CP4-44 prophage; antitoxin of the YeeV-YeeU toxin-antitoxin system b2004 10 None None None 49176119 Common uxaB altronate oxidoreductase, NAD-dependent b1521 84 COG0246 MtlD, Mannitol-1-phosphate/altronate dehydrogenases Carbohydrate transport and metabolism 16131426 Common yiaG predicted transcriptional regulator b3555 9 COG2944 COG2944, Predicted transcriptional regulator Transcription 16128333 Common mhpB 2,3-dihydroxyphenylpropionate 1,2-dioxygenase b0348 30 COG1355 COG1355, Predicted dioxygenase General function prediction only 90111360 Common yedQ predicted diguanylate cyclase b1956 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 16129628 Common ydhW predicted protein b1672 5 None None None 16131529 Common setC predicted sugar efflux system b3659 32 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16129262 Common puuB gamma-Glu-putrescine oxidase, FAD/NAD(P)-binding b1301 130 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 16130399 Common ypfI predicted hydrolase b2474 48 COG1444 COG1444, Predicted P-loop ATPase fused to an acetyltransferase General function prediction only 16130437 Common yfgL protein assembly complex, lipoprotein component b2512 118 COG1520 COG1520, FOG: WD40-like repeat Function unknown 16132204 Common ytjB conserved protein b4387 17 COG3726 AhpA, Uncharacterized membrane protein affecting hemolysin expression General function prediction only 16130660 Common iap aminopeptidase in alkaline phosphatase isozyme conversion b2753 36 COG2234 Iap, Predicted aminopeptidases General function prediction only 16132172 Common mrr methylated adenine and cytosine restriction protein b4351 43 COG1715 Mrr, Restriction endonuclease Defense mechanisms 16130667 Common ygcL predicted protein b2760 14 None None None 90111254 Common ydaQ Rac prophage; conserved protein b1346 4 None None None 49176314 Common tdcG L-serine dehydratase 3 b4471 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 16129361 Common paaY predicted hexapeptide repeat acetyltransferase b1400 206 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 16128811 Common ybjH predicted protein b0843 2 None None None 90111281 Common maeA malate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme) b1479 199 COG0281 SfcA, Malic enzyme Energy production and conversion 16130238 Common folX D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase b2303 47 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 16130345 Common yfeK predicted protein b2419 6 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 16130421 Common hda ATPase regulatory factor involved in DnaA inactivation b2496 166 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 90111514 Common yggG predicted peptidase b2936 117 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 16129513 Common ydfQ Qin prophage; predicted lysozyme b1554 24 COG3772 COG3772, Phage-related lysozyme (muraminidase) General function prediction only 16129741 Common yeaK conserved protein b1787 16 COG2606 EbsC, Uncharacterized conserved protein Function unknown 16130579 Common ygaU predicted protein b2665 59 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 16128498 Common glxK glycerate kinase II b0514 81 COG1929 COG1929, Glycerate kinase Carbohydrate transport and metabolism 16129441 Common osmC osmotically inducible, stress-inducible membrane protein b1482 91 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 16131612 Common asnA asparagine synthetase A b3744 31 COG2502 AsnA, Asparagine synthetase A Amino acid transport and metabolism 16132098 Nonpathogen yjgZ KpLE2 phage-like element; predicted protein b4277 1 None None None 16129623 Common ydhR predicted protein b1667 18 None None None 16130144 Common napD assembly protein for periplasmic nitrate reductase b2207 21 COG3062 NapD, Uncharacterized protein involved in formation of periplasmic nitrate reductase Inorganic ion transport and metabolism 49176350 Common gntT gluconate transporter, high-affinity GNT I system b3415 77 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 16130703 Common sdaC predicted serine transporter b2796 37 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 16128507 Common purE N5-carboxyaminoimidazole ribonucleotide mutase b0523 232 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 16128582 Common ybdH predicted oxidoreductase b0599 74 COG0371 GldA, Glycerol dehydrogenase and related enzymes Energy production and conversion 16131217 Common chiA periplasmic endochitinase b3338 23 None None None 16131659 Common cyaY frataxin, iron-binding and oxidizing protein b3807 44 COG1965 CyaY, Protein implicated in iron transport, frataxin homolog Inorganic ion transport and metabolism 16128695 Common gltA citrate synthase b0720 194 COG0372 GltA, Citrate synthase Energy production and conversion 16128114 Common speE spermidine synthase (putrescine aminopropyltransferase) b0121 126 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 90111290 Common marA DNA-binding transcriptional dual activator of multiple antibiotic resistance b1531 125 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 90111715 Common yjgQ conserved inner membrane protein b4262 110 COG0795 COG0795, Predicted permeases General function prediction only 16130628 Common hycE hydrogenase 3, large subunit b2721 196 COG3261 HycE, Ni,Fe-hydrogenase III large subunit Energy production and conversion 16129727 Common ydjI predicted aldolase b1773 176 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 16131172 Common yhdN conserved protein b3293 26 None None None 16129274 Common ycjQ predicted oxidoreductase, Zn-dependent and NAD(P)-binding b1313 120 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 16131649 Common wzyE predicted Wzy protein involved in ECA polysaccharide chain elongation b3793 13 None None None 16130038 Common yegV predicted kinase b2100 56 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 16128059 Common yabI conserved inner membrane protein b0065 145 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 16131879 Common alr alanine racemase 1, PLP-binding, biosynthetic b4053 200 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 16131239 Common pabA aminodeoxychorismate synthase, subunit II b3360 239 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 16130975 Common ygjK predicted glycosyl hydrolase b3080 20 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 90111683 Common mdtO predicted multidrug efflux system component b4081 14 COG1289 COG1289, Predicted membrane protein Function unknown 90111188 Common ssuC alkanesulfonate transporter subunit b0934 190 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 90111268 Common cybB cytochrome b561 b1418 32 COG3038 CybB, Cytochrome B561 Energy production and conversion 145698333 Common mobB molybdopterin-guanine dinucleotide biosynthesis protein B b3856 98 COG1763 MobB, Molybdopterin-guanine dinucleotide biosynthesis protein Coenzyme metabolism 16131095 Common yhbJ predicted protein with nucleoside triphosphate hydrolase domain b3205 140 COG1660 COG1660, Predicted P-loop-containing kinase General function prediction only 16131031 Common agaC N-acetylgalactosamine-specific enzyme IIC component of PTS b3139 36 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 16129463 Common ydeS predicted fimbrial-like adhesin protein b1504 22 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16131788 Common frwB predicted enzyme IIB component of PTS b3950 68 COG1445 FrwB, Phosphotransferase system fructose-specific component IIB Carbohydrate transport and metabolism 16130008 Common alkA 3-methyl-adenine DNA glycosylase II b2068 103 COG0122 AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 16132210 Common trpR DNA-binding transcriptional repressor, tryptophan-binding b4393 22 COG2973 TrpR, Trp operon repressor Transcription 16129580 Common malY bifunctional beta-cystathionase, PLP-dependent/ regulator of maltose regulon b1622 224 COG1168 MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities Amino acid transport and metabolism 16131134 Common tldD predicted peptidase b3244 170 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 49176390 Common dgoD galactonate dehydratase b4478 115 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 16131609 Common mnmG glucose-inhibited cell-division protein b3741 191 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 90111667 Common yijE predicted permease b3943 142 COG2962 RarD, Predicted permeases General function prediction only 16132035 Common cpdB 2':3'-cyclic-nucleotide 2'-phosphodiesterase b4213 130 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 16130826 Common fbaA fructose-bisphosphate aldolase, class II b2925 174 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 16130282 Common yfdG CPS-53 (KpLE1) prophage; bactoprenol-linked glucose translocase (flippase) b2350 7 COG2246 COG2246, Predicted membrane protein Function unknown 16128418 Common ampG muropeptide transporter b0433 112 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 49176263 Common ascF fused cellobiose/arbutin/salicin-specific PTS enzymes: IIB component/IC component b2715 49 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 16130066 Common yehW predicted transporter subunit: membrane component of ABC superfamily b2128 143 COG1174 OpuBB, ABC-type proline/glycine betaine transport systems, permease component Amino acid transport and metabolism 16131994 Common hfq HF-I, host factor for RNA phage Q beta replication b4172 127 COG1923 Hfq, Uncharacterized host factor I protein General function prediction only 162135910 Common frlR predicted DNA-binding transcriptional regulator b3375 128 COG2188 PhnF, Transcriptional regulators Transcription 16128766 Common ybiA conserved protein b0798 32 COG3236 COG3236, Uncharacterized protein conserved in bacteria Function unknown 90111463 Common yfiP conserved protein b2583 40 COG3148 COG3148, Uncharacterized conserved protein Function unknown 49176402 Common hdfR DNA-binding transcriptional regulator b4480 184 COG0583 LysR, Transcriptional regulator Transcription 16131885 Common ssb single-stranded DNA-binding protein b4059 213 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 16129670 Common pheS phenylalanine tRNA synthetase, alpha subunit b1714 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 16130729 Common ppdB conserved protein b2825 11 COG4795 PulJ, Type II secretory pathway, component PulJ Intracellular trafficking and secretion 16131825 Common rsd stationary phase protein, binds sigma 70 RNA polymerase subunit b3995 24 COG3160 Rsd, Regulator of sigma D Transcription 16131916 Common rpiB ribose 5-phosphate isomerase B/allose 6-phosphate isomerase b4090 129 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 16130558 Common yfjX CP4-57 prophage; predicted antirestriction protein b2643 17 None None None 16129930 Common nac DNA-binding transcriptional dual regulator of nitrogen assimilation b1988 188 COG0583 LysR, Transcriptional regulator Transcription 16129117 Common ycfK e14 prophage; predicted protein b1154 8 None None None 49176425 Common ysgA predicted hydrolase b3830 116 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 16131580 Common yieE predicted phosphopantetheinyl transferase b3712 8 COG2091 Sfp, Phosphopantetheinyl transferase Coenzyme metabolism 16131575 Common tnaC tryptophanase leader peptide b3707 2 None None None 16130202 Common elaA predicted acyltransferase with acyl-CoA N-acyltransferase domain b2267 81 COG2153 ElaA, Predicted acyltransferase General function prediction only 16131335 Common ftsE predicted transporter subunit: ATP-binding component of ABC superfamily b3463 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 16130397 Common dapE N-succinyl-diaminopimelate deacylase b2472 213 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 16130631 Common hycB hydrogenase 3, Fe-S subunit b2724 142 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 16128939 Common hyaB hydrogenase 1, large subunit b0973 107 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 16128187 Common proS prolyl-tRNA synthetase b0194 248 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 16130812 Common zapA protein that localizes to the cytokinetic ring b2910 47 COG3027 COG3027, Uncharacterized protein conserved in bacteria Function unknown 16129664 Common nlpC predicted lipoprotein b1708 141 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 90111280 Common adhP ethanol-active dehydrogenase/acetaldehyde-active reductase b1478 212 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 16132193 Common prfC peptide chain release factor RF-3 b4375 249 COG4108 PrfC, Peptide chain release factor RF-3 Translation, ribosomal structure and biogenesis 16129054 Common fabH 3-oxoacyl-[acyl-carrier-protein] synthase III b1091 231 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 16129666 Common btuE predicted glutathione peroxidase b1710 114 COG0386 BtuE, Glutathione peroxidase Posttranslational modification, protein turnover, chaperones 16129689 Common chbR DNA-binding transcriptional dual regulator b1735 94 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16129913 Common hchA Hsp31 molecular chaperone b1967 49 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 16131328 Common livM leucine/isoleucine/valine transporter subunit b3456 130 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 16131053 Common mtr tryptophan transporter of high affinity b3161 31 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 145698277 Common ynjC fused transporter subunits of ABC superfamily: membrane components b1755 28 COG4135 COG4135, ABC-type uncharacterized transport system, permease component General function prediction only 16128746 Common bioD dethiobiotin synthetase b0778 157 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 16130722 Common argA fused acetylglutamate kinase homolog (inactive)/amino acid N-acetyltransferase b2818 203 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 16131527 Common yicI predicted alpha-glucosidase b3656 82 COG1501 COG1501, Alpha-glucosidases, family 31 of glycosyl hydrolases Carbohydrate transport and metabolism 16129104 Common xisE e14 prophage; predicted excisionase b1141 2 None None None 16130108 Common setB lactose/glucose efflux system b2170 44 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16129830 Common flhE conserved protein b1878 10 None None None 16130224 Common lrhA DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes b2289 132 COG0583 LysR, Transcriptional regulator Transcription 16130260 Common yfcL predicted protein b2325 17 None None None 16132195 Common yjjU predicted esterase b4377 44 COG4667 COG4667, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 16129646 Common ydiM predicted transporter b1690 42 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 16132033 Common ytfG NAD(P)H:quinone oxidoreductase b4211 94 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 16128408 Common thiI sulfurtransferase required for thiamine and 4-thiouridine biosynthesis b0423 95 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 90111491 Common ygdI predicted protein b2809 13 None None None 16130473 Common yphF predicted sugar transporter subunit: periplasmic-binding component of ABC superfamily b2548 86 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 16129601 Common ydhI predicted inner membrane protein b1643 9 None None None 16131479 Common gpsA glycerol-3-phosphate dehydrogenase (NAD+) b3608 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 157783151 Nonpathogen ythA expressed protein b4655 1 None None None 16131755 Common sbp sulfate transporter subunit b3917 90 COG1613 Sbp, ABC-type sulfate transport system, periplasmic component Inorganic ion transport and metabolism 145698250 Common yciY hypothetical protein b4595 6 None None None 16130371 Common yffO CPZ-55 prophage; predicted protein b2446 2 None None None 16130936 Common zupT zinc transporter b3040 97 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 16130316 Common ypdE predicted peptidase b2384 90 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 16129414 Common yncH predicted protein b1455 2 None None None 16131059 Common rbfA 30s ribosome binding factor b3167 174 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 145698318 Nonpathogen yrhD hypothetical protein b4612 1 None None None 16129226 Nonpathogen trpL trp operon leader peptide b1265 1 None None None 16129092 Common phoQ sensory histidine kinase in two-compoent regulatory system with PhoP b1129 216 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 16128961 Common torR DNA-binding response regulator in two-component regulatory system with TorS b0995 220 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 16128549 Common envY DNA-binding transcriptional activator of porin biosynthesis b0566 10 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16128920 Common rmf ribosome modulation factor b0953 21 COG3130 Rmf, Ribosome modulation factor Translation, ribosomal structure and biogenesis 90111261 Common stfR Rac prophage; predicted tail fiber protein b1372 11 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 16128611 Common lipA lipoate synthase b0628 190 COG0320 LipA, Lipoate synthase Coenzyme metabolism 16129343 Common ynbE predicted lipoprotein b1382 28 None None None 16131938 Common basS sensory histidine kinase in two-component regulatory system with BasR b4112 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 16131721 Common yihT predicted aldolase b3881 25 COG3684 LacD, Tagatose-1,6-bisphosphate aldolase Carbohydrate transport and metabolism 16129386 Common rimL ribosomal-protein-L7/L12-serine acetyltransferase b1427 81 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 90111553 Common folP 7,8-dihydropteroate synthase b3177 218 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 90111535 Common rlmG predicted methyltransferase small domain b3084 95 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 16129594 Common pdxY pyridoxal kinase 2/pyridoxine kinase b1636 58 COG2240 PdxK, Pyridoxal/pyridoxine/pyridoxamine kinase Coenzyme metabolism 16129655 Common ydiS predicted oxidoreductase with FAD/NAD(P)-binding domain b1699 116 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 16131428 Common insJ IS150 protein InsA b3557 24 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 16129108 Common ymfK e14 prophage; repressor protein phage e14 b1145 30 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 16130665 Common ygcJ predicted protein b2758 42 None None None 16130640 Common mutS methyl-directed mismatch repair protein b2733 201 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 16130819 Common argK membrane ATPase/protein kinase b2918 100 COG1703 ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family Amino acid transport and metabolism 94541130 Common yifL predicted lipoprotein b4558 6 COG5567 COG5567, Predicted small periplasmic lipoprotein Cell motility and secretion 16128179 Common ldcC lysine decarboxylase 2, constitutive b0186 88 COG1982 LdcC, Arginine/lysine/ornithine decarboxylases Amino acid transport and metabolism 145698236 Common lolA chaperone for lipoproteins b0891 70 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 16130230 Common yfbV conserved inner membrane protein b2295 23 COG3092 COG3092, Uncharacterized protein conserved in bacteria Function unknown 90111115 Common mhpC 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase b0349 131 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 16129012 Common mdoH glucan biosynthesis: glycosyl transferase b1049 54 COG2943 MdoH, Membrane glycosyltransferase Cell envelope biogenesis, outer membrane 16130595 Common ygaH predicted inner membrane protein b2683 8 None None None 145698283 Common yeeX conserved protein b2007 22 COG2926 COG2926, Uncharacterized protein conserved in bacteria Function unknown 16129824 Common cmoB predicted S-adenosyl-L-methionine-dependent methyltransferase b1871 54 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 16130270 Common yfcR predicted fimbrial-like adhesin protein b2335 7 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16130592 Common proW glycine betaine transporter subunit b2678 194 COG4176 ProW, ABC-type proline/glycine betaine transport system, permease component Amino acid transport and metabolism 16132013 Common ulaR DNA-binding transcriptional dual regulator b4191 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 16132005 Common yjfK conserved protein b4183 10 None None None 94541103 Common insA KpLE2 phage-like element; IS1 repressor protein InsA b4516 14 COG3677 COG3677, Transposase and inactivated derivatives DNA replication, recombination, and repair 16129989 Common cpsB mannose-1-phosphate guanyltransferase b2049 164 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 16129934 Common cobU bifunctional cobinamide kinase/ cobinamide phosphate guanylyltransferase b1993 129 COG2087 CobU, Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase Coenzyme metabolism 16130895 Common hybB predicted hydrogenase 2 cytochrome b type component b2995 29 COG5557 COG5557, Polysulphide reductase Energy production and conversion 16129095 Common hflD predicted lysogenization regulator b1132 41 COG2915 COG2915, Uncharacterized protein involved in purine metabolism General function prediction only 16129747 Common yoaF conserved outer membrane protein b1793 18 COG3042 Hlx, Putative hemolysin General function prediction only 90111080 Common caiE predicted acyl transferase b0035 194 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 16130335 Common yfeR predicted DNA-binding transcriptional regulator b2409 192 COG0583 LysR, Transcriptional regulator Transcription 16130732 Common lgt phosphatidylglycerol-prolipoprotein diacylglyceryl transferase b2828 205 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 16131242 Common ppiA peptidyl-prolyl cis-trans isomerase A (rotamase A) b3363 199 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 16129030 Common yceH conserved protein b1067 41 COG3132 COG3132, Uncharacterized protein conserved in bacteria Function unknown 16129845 Common insB IS1 transposase InsAB' b1893 20 COG1662 InsB, Transposase and inactivated derivatives, IS1 family DNA replication, recombination, and repair 16129213 Common tonB membrane spanning protein in TonB-ExbB-ExbD complex b1252 31 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 16129733 Common gapA glyceraldehyde-3-phosphate dehydrogenase A b1779 222 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 16129487 Common ydeA predicted arabinose transporter b1528 150 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 90111144 Common ybbW predicted allantoin transporter b0511 51 COG1953 FUI1, Cytosine/uracil/thiamine/allantoin permeases Nucleotide transport and metabolism / Coenzyme metabolism 16130994 Common yqjE conserved inner membrane protein b3099 10 COG5393 COG5393, Predicted membrane protein Function unknown 16130166 Common gyrA DNA gyrase (type II topoisomerase), subunit A b2231 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 90111385 Common fbaB fructose-bisphosphate aldolase class I b2097 57 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 16131520 Common rpoZ RNA polymerase, omega subunit b3649 110 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 16128889 Common mukF Involved in chromosome partioning, Ca2+ binding protein b0922 19 COG3006 MukF, Uncharacterized protein involved in chromosome partitioning Cell division and chromosome partitioning 16131976 Common frdD fumarate reductase (anaerobic), membrane anchor subunit b4151 21 COG3080 FrdD, Fumarate reductase subunit D Energy production and conversion 16130700 Common syd predicted protein b2793 19 None None None 16131040 Common yraN conserved protein b3148 128 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 16128296 Common betA choline dehydrogenase, a flavoprotein b0311 90 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 16128802 Common yliF predicted diguanylate cyclase b0834 176 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 16128256 Common yagH CP4-6 prophage; predicted xylosidase/arabinosidase b0271 42 COG3507 XynB, Beta-xylosidase Carbohydrate transport and metabolism 16129221 Common trpA tryptophan synthase, alpha subunit b1260 213 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 16130300 Common emrK EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component b2368 142 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 16128782 Common ompX outer membrane protein b0814 11 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 49176083 Common ycgL conserved protein b1179 35 COG3100 COG3100, Uncharacterized protein conserved in bacteria Function unknown 16131741 Common rhaM L-rhamnose mutarotase b3901 39 COG3254 COG3254, Uncharacterized conserved protein Function unknown 90111411 Common menF isochorismate synthase 2 b2265 221 COG1169 MenF, Isochorismate synthase Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism 16130001 Common wzb protein-tyrosine phosphatase b2061 134 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 90111401 Common yejA predicted oligopeptide transporter subunit b2177 172 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 16131492 Common rfaC ADP-heptose:LPS heptosyl transferase I b3621 89 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 16131838 Common yjaB predicted acetyltransferase b4012 57 COG0456 RimI, Acetyltransferases General function prediction only 16131396 Common yhjG predicted outer membrane biogenesis protein b3524 34 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 16128025 Common dapB dihydrodipicolinate reductase b0031 217 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 16128784 Common yliL predicted protein b0816 1 None None None 16130017 Common mdtD multidrug efflux system protein b2077 192 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16129644 Common ydiK predicted inner membrane protein b1688 88 COG0628 PerM, Predicted permease General function prediction only 90111371 Common yeeY predicted DNA-binding transcriptional regulator b2015 158 COG0583 LysR, Transcriptional regulator Transcription 16128789 Common ybiU predicted protein b0821 11 None None None 145698303 Common ypjD predicted inner membrane protein b2611 58 COG4137 COG4137, ABC-type uncharacterized transport system, permease component General function prediction only 16129635 Common sufE sulfur acceptor protein b1679 93 COG2166 COG2166, SufE protein probably involved in Fe-S center assembly General function prediction only 16130747 Common kduI predicted 5-keto 4-deoxyuronate isomerase b2843 28 COG3717 KduI, 5-keto 4-deoxyuronate isomerase Carbohydrate transport and metabolism 16130806 Common gcvH glycine cleavage complex lipoylprotein b2904 187 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 94541124 Common yhdL conserved protein b4550 17 COG3036 COG3036, Uncharacterized protein conserved in bacteria Function unknown 16131386 Common mdtF multidrug transporter, RpoS-dependent b3514 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 16128159 Common dapD 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase b0166 140 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 16130087 Common mglA fused methyl-galactoside transporter subunits of ABC superfamily: ATP-binding components b2149 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 90111395 Common yohD conserved inner membrane protein b2136 67 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 49176462 Common ecnA entericidin A membrane lipoprotein, antidote entericidin B b4410 3 COG5510 COG5510, Predicted small secreted protein Function unknown 16129147 Common umuC DNA polymerase V, subunit C b1184 182 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 16131046 Common yhbP conserved protein b3154 20 COG3787 COG3787, Uncharacterized protein conserved in bacteria Function unknown 16128853 Common cydC fused cysteine transporter subunits of ABC superfamily: membrane component/ATP-binding component b0886 249 COG4987 CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 162135897 Common ybiN predicted SAM-dependent methyltransferase b0807 28 COG3129 COG3129, Predicted SAM-dependent methyltransferase General function prediction only 90111542 Common tdcF predicted L-PSP (mRNA) endoribonuclease b3113 183 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 16128437 Common tesB acyl-CoA thioesterase II b0452 77 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 16131437 Common xylF D-xylose transporter subunit b3566 105 COG4213 XylF, ABC-type xylose transport system, periplasmic component Carbohydrate transport and metabolism 16129856 Common yecH predicted protein b1906 13 None None None 16131671 Common pldA outer membrane phospholipase A b3821 52 COG2829 PldA, Outer membrane phospholipase A Cell envelope biogenesis, outer membrane 90111107 Common yagB CP4-6 prophage; conserved protein b0266 10 None None None 49176296 Common yghQ predicted inner membrane protein b2983 10 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 90111528 Common tolC transport channel b3035 137 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 16129534 Common ydfD Qin prophage; predicted protein b1576 3 None None None 16131861 Common malK fused maltose transport subunit, ATP-binding component of ABC superfamily/regulatory protein b4035 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 16130714 Common ygdD conserved inner membrane protein b2807 71 COG2363 COG2363, Uncharacterized small membrane protein Function unknown 16128863 Common dmsC dimethyl sulfoxide reductase, anaerobic, subunit C b0896 24 COG3302 DmsC, DMSO reductase anchor subunit General function prediction only 16130122 Common yejH predicted ATP-dependet helicase b2184 133 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 16129783 Common htpX predicted endopeptidase b1829 188 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 49176156 Common proQ predicted structural transport element b1831 35 COG3109 ProQ, Activator of osmoprotectant transporter ProP Signal transduction mechanisms 90111726 Common sgcX KpLE2 phage-like element; predicted endoglucanase with Zn-dependent exopeptidase domain b4305 84 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 16131144 Common accC acetyl-CoA carboxylase, biotin carboxylase subunit b3256 232 COG0439 AccC, Biotin carboxylase Lipid metabolism 16128313 Common yahN neutral amino-acid efflux system b0328 101 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 90111478 Common csiR DNA-binding transcriptional dual regulator b2664 117 COG1802 GntR, Transcriptional regulators Transcription 16128664 Common pgm phosphoglucomutase b0688 208 COG0033 Pgm, Phosphoglucomutase Carbohydrate transport and metabolism 16131849 Common pagB conserved protein b4023 9 None None None 16131962 Common cutA copper binding protein, copper sensitivity b4137 101 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 16129504 Common pinQ Qin prophage; predicted site-specific recombinase b1545 136 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 16130600 Common gshA gamma-glutamate-cysteine ligase b2688 58 COG2918 GshA, Gamma-glutamylcysteine synthetase Coenzyme metabolism 90111231 Common emtA lytic murein endotransglycosylase E b1193 66 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 16131432 Common wecH conserved inner membrane protein b3561 31 COG3274 COG3274, Uncharacterized protein conserved in bacteria Function unknown 16131275 Common yrfF predicted inner membrane protein b3398 11 None None None 16131714 Common yihN predicted transporter b3874 35 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 16130153 Common rcsD phosphotransfer intermediate protein in two-component regulatory system with RcsBC b2216 64 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 90111205 Common ghrA 2-ketoacid reductase b1033 227 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 16128106 Common pdhR DNA-binding transcriptional dual regulator b0113 150 COG2186 FadR, Transcriptional regulators Transcription 16131726 Common yihY predicted inner membrane protein b3886 117 COG1295 Rbn, Predicted membrane protein Function unknown 16130453 Common iscA FeS cluster assembly protein b2528 163 COG0316 IscA, Uncharacterized conserved protein Function unknown 16130253 Common truA pseudouridylate synthase I b2318 236 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 16129082 Common nagK N-acetyl-D-glucosamine kinase b1119 144 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 16128309 Common yahJ predicted deaminase with metallo-dependent hydrolase domain b0324 66 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 16130079 Common yohJ conserved inner membrane protein b2141 26 COG1380 COG1380, Putative effector of murein hydrolase LrgA General function prediction only 90111487 Common ygcR predicted flavoprotein b2770 83 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 90111486 Common ygcQ predicted flavoprotein b2769 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 16130137 Common ccmB heme exporter subunit b2200 81 COG2386 CcmB, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 16130409 Common hyfD hydrogenase 4, membrane subunit b2484 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 16129420 Common pptA 4-oxalocrotonate tautomerase b1461 13 COG1942 COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog General function prediction only 16130096 Common yeiH conserved inner membrane protein b2158 111 COG2855 COG2855, Predicted membrane protein Function unknown 16131222 Common yheL predicted intracellular sulfur oxidation protein b3343 20 COG2168 DsrH, Uncharacterized conserved protein involved in oxidation of intracellular sulfur Inorganic ion transport and metabolism 90111322 Common ydjY predicted protein b1751 3 None None None 16128376 Common yaiE conserved protein b0391 52 COG3123 COG3123, Uncharacterized protein conserved in bacteria Function unknown 16131448 Common yiaM predicted transporter b3577 65 COG3090 DctM, TRAP-type C4-dicarboxylate transport system, small permease component Carbohydrate transport and metabolism 90111418 Common mnmC fused 5-methylaminomethyl-2-thiouridine-forming enzyme methyltransferase/FAD-dependent demodification enzyme b2324 89 COG4121 COG4121, Uncharacterized conserved protein Function unknown 16131549 Common yidK predicted transporter b3679 121 COG4146 COG4146, Predicted symporter General function prediction only 16130403 Common dapA dihydrodipicolinate synthase b2478 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 16128653 Common nagA N-acetylglucosamine-6-phosphate deacetylase b0677 118 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 90111674 Common zraP Zn-binding periplasmic protein b4002 5 COG3678 CpxP, P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism 16128457 Common htpG molecular chaperone HSP90 family b0473 151 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 16129251 Common sapF predicted antimicrobial peptide transporter subunit b1290 249 COG4167 SapF, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 90111100 Common fadE acyl coenzyme A dehydrogenase b0221 148 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 16131350 Common nikC nickel transporter subunit b3478 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 16128968 Common agp glucose-1-phosphatase/inositol phosphatase b1002 17 None None None 16128152 Common mtn 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase b0159 105 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 16129619 Common cfa cyclopropane fatty acyl phospholipid synthase (unsaturated-phospholipid methyltransferase) b1661 135 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 16129839 Common cheW purine-binding chemotaxis protein b1887 121 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 16129925 Common shiA shikimate transporter b1981 130 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 16130956 Common ttdR predicted DNA-binding transcriptional regulator b3060 168 COG0583 LysR, Transcriptional regulator Transcription 16128124 Common panD aspartate 1-decarboxylase b0131 130 COG0853 PanD, Aspartate 1-decarboxylase Coenzyme metabolism 90111156 Common lipB lipoyl-protein ligase b0630 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 16131455 Common yiaT predicted protein b3584 34 COG3713 OmpV, Outer membrane protein V Cell envelope biogenesis, outer membrane 16130311 Common yfdZ prediected aminotransferase, PLP-dependent b2379 240 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 16128941 Common hyaD protein involved in processing of HyaA and HyaB proteins b0975 74 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 16130648 Common rpoS RNA polymerase, sigma S (sigma 38) factor b2741 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 90111226 Common ymgD predicted protein b1171 2 None None None 16128628 Common ybeR predicted protein b0645 5 None None None 49176415 Common aslB predicted regulator of arylsulfatase activity b3800 93 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 16130441 Common yfgA conserved protein b2516 45 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 16132213 Common rob DNA-binding transcriptional activator b4396 112 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16129127 Common ycgZ predicted protein b1164 2 None None None 16129554 Common ynfM predicted transporter b1596 209 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16128768 Common ybiB predicted transferase/phosphorylase b0800 149 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 16131542 Nonpathogen ivbL ilvB operon leader peptide b3672 1 None None None 16128043 Common apaH diadenosine tetraphosphatase b0049 103 COG0639 ApaH, Diadenosine tetraphosphatase and related serine/threonine protein phosphatases Signal transduction mechanisms 16131295 Common rtcB conserved protein b3421 121 COG1690 RtcB, Uncharacterized conserved protein Function unknown 16128480 Common ybbP predicted inner membrane protein b0496 88 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 94541117 Common yohO predicted protein b4542 4 None None None 16130279 Common vacJ predicted lipoprotein b2346 94 COG2853 VacJ, Surface lipoprotein Cell envelope biogenesis, outer membrane 16131604 Common atpF F0 sector of membrane-bound ATP synthase, subunit b b3736 127 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 16128133 Common ecpD predicted periplasmic pilin chaperone b0140 24 COG3121 FimC, P pilus assembly protein, chaperone PapD Cell motility and secretion / Intracellular trafficking and secretion 16128208 Common lpcA D-sedoheptulose 7-phosphate isomerase b0222 124 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 16128881 Common msbA fused lipid transporter subunits of ABC superfamily: membrane component/ATP-binding component b0914 248 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 16129969 Common ugd UDP-glucose 6-dehydrogenase b2028 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 16130199 Common menD bifunctional 2-oxoglutarate decarboxylase/ SHCHC synthase b2264 102 COG1165 MenD, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Coenzyme metabolism 90111389 Common yehL predicted transporter subunit: ATP-binding component of ABC superfamily b2119 47 COG0714 COG0714, MoxR-like ATPases General function prediction only 16131626 Nonpathogen ilvL ilvG operon leader peptide b3766 1 None None None 16128145 Common fhuD iron-hydroxamate transporter subunit b0152 41 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 16130315 Common fryA fused predicted PTS enzymes: Hpr component/enzyme I component/enzyme IIA component b2383 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 16131069 Common rrmJ 23S rRNA methyltransferase b3179 138 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 16129170 Common prs phosphoribosylpyrophosphate synthase b1207 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 16129196 Common rssB response regulator of RpoS b1235 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 16130945 Common glgS predicted glycogen synthesis protein b3049 5 None None None 16128619 Common ybeA conserved protein b0636 165 COG1576 COG1576, Uncharacterized conserved protein Function unknown 16130577 Common gabP gamma-aminobutyrate transporter b2663 185 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 16131835 Common purD phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase b4005 232 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 145698241 Common ymfL e14 prophage; predicted DNA-binding transcriptional regulator b1147 4 None None None 16132080 Common valS valyl-tRNA synthetase b4258 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 16129326 Common ynaK Rac prophage; conserved protein b1365 31 COG1475 Spo0J, Predicted transcriptional regulators Transcription 16128263 Common yagL CP4-6 prophage; DNA-binding protein b0278 6 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 16131188 Common rplX 50S ribosomal subunit protein L24 b3309 211 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 94541090 Common ymdF conserved protein b4518 12 None None None 16131181 Common rpmD 50S ribosomal subunit protein L30 b3302 154 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 16130247 Common purF amidophosphoribosyltransferase b2312 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 16130688 Common mazG nucleoside triphosphate pyrophosphohydrolase b2781 156 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 16128329 Common lacZ beta-D-galactosidase b0344 71 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 90111358 Common fliO flagellar biosynthesis protein b1947 7 COG3190 FliO, Flagellar biogenesis protein Cell motility and secretion 16128336 Common mhpF acetaldehyde-CoA dehydrogenase II, NAD-binding b0351 37 COG4569 MhpF, Acetaldehyde dehydrogenase (acetylating) Secondary metabolites biosynthesis, transport, and catabolism 90111164 Common ybgO predicted fimbrial-like adhesin protein b0716 7 None None None 16130524 Common yfiR predicted protein b2603 15 None None None 16132089 Common idnD L-idonate 5-dehydrogenase, NAD-binding b4267 202 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 145698257 Common ydcQ predicted DNA-binding transcriptional regulator b1438 19 COG1598 COG1598, Uncharacterized conserved protein Function unknown 16132054 Common fbp fructose-1,6-bisphosphatase I b4232 108 COG0158 Fbp, Fructose-1,6-bisphosphatase Carbohydrate transport and metabolism 16130792 Common lysS lysine tRNA synthetase, constitutive b2890 249 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 90111571 Common gspL general secretory pathway component, cryptic b3333 12 COG3297 PulL, Type II secretory pathway, component PulL Intracellular trafficking and secretion 16130619 Common hypF carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases b2712 117 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 16129450 Common yddW predicted liprotein b1491 40 COG1649 COG1649, Uncharacterized protein conserved in bacteria Function unknown 16131500 Common rfaS lipopolysaccharide core biosynthesis protein b3629 4 None None None 16128538 Common ybcS DLP12 prophage; predicted lysozyme b0555 44 COG3772 COG3772, Phage-related lysozyme (muraminidase) General function prediction only 16129027 Common grxB glutaredoxin 2 (Grx2) b1064 19 COG2999 GrxB, Glutaredoxin 2 Posttranslational modification, protein turnover, chaperones 16129001 Common csgF predicted transport protein b1038 9 None None None 90111614 Common ghrB 2-keto-D-gluconate reductase (glyoxalate reductase) (2-ketoaldonate reductase) b3553 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 16129379 Common mokB regulatory peptide b1420 2 None None None 16130413 Common hyfH hydrogenase 4, Fe-S subunit b2488 66 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 16128493 Common glxR tartronate semialdehyde reductase, NADH-dependent b0509 188 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 49176373 Common bax conserved protein b3570 31 COG2992 Bax, Uncharacterized FlgJ-related protein General function prediction only 16129357 Common paaI predicted thioesterase b1396 68 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 16130062 Common yehS conserved protein b2124 31 COG4807 COG4807, Uncharacterized protein conserved in bacteria Function unknown 16131282 Common ompR DNA-binding response regulator in two-component regulatory system with EnvZ b3405 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 16130656 Common ygbE conserved inner membrane protein b2749 10 None None None 90111089 Common yadM predicted fimbrial-like adhesin protein b0138 3 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16130691 Common relA (p)ppGpp synthetase I/GTP pyrophosphokinase b2784 205 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 16130589 Common nrdE ribonucleoside-diphosphate reductase 2, alpha subunit b2675 221 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 16131777 Common metB cystathionine gamma-synthase, PLP-dependent b3939 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 16129701 Common astA arginine succinyltransferase b1747 37 COG3138 AstA, Arginine/ornithine N-succinyltransferase beta subunit Amino acid transport and metabolism 16130499 Common nadB quinolinate synthase, L-aspartate oxidase (B protein) subunit b2574 226 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 16130856 Common yggW predicted oxidoreductase b2955 206 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 16131076 Common rplU 50S ribosomal subunit protein L21 b3186 215 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 162135909 Common frlB fructoselysine-6-P-deglycase b3371 224 COG2222 AgaS, Predicted phosphosugar isomerases Cell envelope biogenesis, outer membrane 16131014 Common yhaC predicted protein b3121 2 None None None 16132026 Common yjfZ predicted protein b4204 2 None None None 16130743 Common lysR DNA-binding transcriptional dual regulator b2839 176 COG0583 LysR, Transcriptional regulator Transcription 16130222 Common nuoB NADH:ubiquinone oxidoreductase, chain B b2287 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 162135902 Common dos cAMP phosphodiesterase, heme-regulated b1489 186 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 16129538 Common rspB predicted oxidoreductase, Zn-dependent and NAD(P)-binding b1580 212 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 16129296 Common ogt O-6-alkylguanine-DNA:cysteine-protein methyltransferase b1335 198 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 16130545 Common yfjK CP4-57 prophage; conserved protein b2627 16 COG1204 COG1204, Superfamily II helicase General function prediction only 90111497 Common yqeK predicted protein b2849 1 None None None 49176410 Common rffD UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase b3787 206 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 16128316 Common prpB 2-methylisocitrate lyase b0331 135 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 16131942 Common adiY DNA-binding transcriptional activator b4116 9 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16131798 Common argH argininosuccinate lyase b3960 234 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 16131075 Common rpmA 50S ribosomal subunit protein L27 b3185 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 90111621 Common yibQ predicted polysaccharide deacetylase b3614 65 COG2861 COG2861, Uncharacterized protein conserved in bacteria Function unknown 16129370 Common ynbB predicted CDP-diglyceride synthase b1409 215 COG4589 COG4589, Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase General function prediction only 16131038 Common yraL predicted methyltransferase b3146 209 COG0313 COG0313, Predicted methyltransferases General function prediction only 16131418 Common yhjX predicted transporter b3547 103 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 16128575 Common fepB iron-enterobactin transporter subunit b0592 53 COG4592 FepB, ABC-type Fe2+-enterobactin transport system, periplasmic component Inorganic ion transport and metabolism 16130257 Common yfcJ predicted transporter b2322 37 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16128239 Common perR CP4-6 prophage; predicted DNA-binding transcriptional regulator b0254 120 COG0583 LysR, Transcriptional regulator Transcription 16131665 Common uvrD DNA-dependent ATPase I and helicase II b3813 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 16128500 Common allC allantoate amidohydrolase b0516 86 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 16128642 Common ybeY conserved protein b0659 202 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 16131028 Common agaS tagatose-6-phosphate ketose/aldose isomerase b3136 30 COG2222 AgaS, Predicted phosphosugar isomerases Cell envelope biogenesis, outer membrane 16129042 Common flgH flagellar protein of basal-body outer-membrane L ring b1079 97 COG2063 FlgH, Flagellar basal body L-ring protein Cell motility and secretion 16128195 Common yafC predicted DNA-binding transcriptional regulator b0208 191 COG0583 LysR, Transcriptional regulator Transcription 16130492 Common rnc RNase III b2567 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 16128578 Common entB isochorismatase b0595 87 COG1535 EntB, Isochorismate hydrolase Secondary metabolites biosynthesis, transport, and catabolism 16129713 Common nudG pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase b1759 162 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 90111364 Common mtfA conserved protein b1976 57 COG3228 COG3228, Uncharacterized protein conserved in bacteria Function unknown 145698327 Common nepI predicted transporter b3662 177 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 49176249 Common yfjP CP4-57 prophage; predicted GTP-binding protein b2632 40 COG3596 COG3596, Predicted GTPase General function prediction only 16129056 Common fabG 3-oxoacyl-[acyl-carrier-protein] reductase b1093 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 16128707 Common mngB alpha-mannosidase b0732 51 COG0383 AMS1, Alpha-mannosidase Carbohydrate transport and metabolism 16131098 Common mtgA biosynthetic peptidoglycan transglycosylase b3208 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 90111576 Common frlA predicted fructoselysine transporter b3370 188 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 16127999 Common yaaX predicted protein b0005 6 None None None 16130365 Common eutC ethanolamine ammonia-lyase, small subunit (light chain) b2440 54 COG4302 EutC, Ethanolamine ammonia-lyase, small subunit Amino acid transport and metabolism 16128174 Common lpxA UDP-N-acetylglucosamine acetyltransferase b0181 153 COG1043 LpxA, Acyl- acyl carrier protein 16131390 Common yhjA predicted cytochrome C peroxidase b3518 94 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 16128726 Common galT galactose-1-phosphate uridylyltransferase b0758 79 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 94541136 Common yehK predicted protein b4541 2 None None None 16128166 Common dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase b0173 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 16131167 Common fmt 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase b3288 217 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 16130184 Common yfaY conserved protein b2249 140 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 16131900 Common nrfE heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfE b4074 119 COG1138 CcmF, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 16130488 Common acpS holo-[acyl-carrier-protein] synthase 1 b2563 138 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 16130701 Common queF conserved protein b2794 88 COG2904 COG2904, Uncharacterized protein conserved in bacteria Function unknown 16128057 Common araB L-ribulokinase b0063 82 COG1069 AraB, Ribulose kinase Energy production and conversion 16130280 Common yfdC predicted inner membrane protein b2347 40 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 16131382 Common hdeA stress response protein acid-resistance protein b3510 4 None None None 16128607 Common crcB predicted inner membrane protein associated with chromosome condensation b0624 141 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 94541099 Common ybdZ conserved protein b4511 26 COG3251 COG3251, Uncharacterized protein conserved in bacteria Function unknown 16130612 Common srlD sorbitol-6-phosphate dehydrogenase b2705 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 90111665 Common kdgT 2-keto-3-deoxy-D-gluconate transporter b3909 27 None None None 16128637 Common gltJ glutamate and aspartate transporter subunit b0654 172 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 16128753 Common moaE molybdopterin synthase, large subunit b0785 160 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 16128918 Common pqiB paraquat-inducible protein B b0951 66 COG3008 PqiB, Paraquat-inducible protein B General function prediction only 16131266 Common damX predicted protein b3388 17 COG3266 DamX, Uncharacterized protein conserved in bacteria Function unknown 16130098 Common yeiI predicted kinase b2160 117 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 16128845 Common ybjX conserved protein b0877 21 COG2990 VirK, Uncharacterized protein conserved in bacteria Function unknown 16129834 Common cheY chemotaxis regulator transmitting signal to flagellar motor component b1882 218 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 90111670 Common sthA pyridine nucleotide transhydrogenase, soluble b3962 241 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 16128547 Common appY DLP12 prophage; DNA-binding transcriptional activator b0564 63 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16131982 Common yjeN predicted protein b4157 2 None None None 16129563 Common ydgI predicted arginine/ornithine antiporter transporter b1605 134 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 16128687 Common ybgK predicted enzyme subunit b0712 115 COG1984 DUR1, Allophanate hydrolase subunit 2 Amino acid transport and metabolism 16130981 Common ygjQ predicted thioredoxin-like protein b3086 49 COG2949 SanA, Uncharacterized membrane protein Function unknown 90111177 Common potG putrescine transporter subunit: ATP-binding component of ABC superfamily b0855 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 16128555 Common cusC copper/silver efflux system, outer membrane component b0572 111 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 16129613 Common ydhO predicted lipoprotein b1655 132 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 90111453 Common pepB aminopeptidase B b2523 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 16130391 Common ypfG predicted protein b2466 16 None None None 16128388 Common malZ maltodextrin glucosidase b0403 158 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 16129974 Common wbbI conserved protein b2034 9 None None None 16130582 Common ygaP predicted inner membrane protein with hydrolase activity b2668 67 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 16129603 Common ydhK conserved inner membrane protein b1645 42 COG1289 COG1289, Predicted membrane protein Function unknown 16131020 Common garD (D)-galactarate dehydrogenase b3128 73 COG2721 UxaA, Altronate dehydratase Carbohydrate transport and metabolism 16131927 Common phnG carbon-phosphorus lyase complex subunit b4101 31 COG3624 PhnG, Uncharacterized enzyme of phosphonate metabolism Inorganic ion transport and metabolism 16130926 Common parE DNA topoisomerase IV, subunit B b3030 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 90111700 Common yjfN predicted protein b4188 8 None None None 16131210 Common gspJ predicted general secretory pathway component, cryptic b3331 21 COG4795 PulJ, Type II secretory pathway, component PulJ Intracellular trafficking and secretion 16128722 Common aroG 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine repressible b0754 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 16128717 Common ybgF predicted protein b0742 102 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 90111448 Common upp uracil phosphoribosyltransferase b2498 165 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 16130011 Common yegJ predicted protein b2071 12 COG3779 COG3779, Uncharacterized protein conserved in bacteria Function unknown 90111331 Common yeaJ predicted diguanylate cyclase b1786 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 16128482 Common ybbC predicted protein b0498 1 None None None 16131877 Common qor quinone oxidoreductase, NADPH-dependent b4051 176 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 16128037 Common fixC predicted oxidoreductase with FAD/NAD(P)-binding domain b0043 134 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 16128816 Common ybjM predicted inner membrane protein b0848 8 None None None 16130985 Common ygjV conserved inner membrane protein b3090 17 None None None 90111651 Common yigG predicted inner membrane protein b3818 3 None None None 16131130 Common aaeB p-hydroxybenzoic acid efflux system component b3240 46 COG1289 COG1289, Predicted membrane protein Function unknown 16131813 Common rplK 50S ribosomal subunit protein L11 b3983 246 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 90111738 Common yjiA predicted GTPase b4352 126 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 16131597 Common glmS L-glutamine:D-fructose-6-phosphate aminotransferase b3729 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 16131989 Common yjeF predicted carbohydrate kinase b4167 222 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 90111306 Common uidC predicted outer membrane porin protein b1615 3 None None None 16130914 Common plsC 1-acyl-sn-glycerol-3-phosphate acyltransferase b3018 90 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 16131240 Common fic stationary-phase protein, cell division b3361 37 COG2184 Fic, Protein involved in cell division Cell division and chromosome partitioning 16128046 Common pdxA 4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent b0052 159 COG1995 PdxA, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 90111641 Common dgoT D-galactonate transporter b3691 197 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 16128013 Common nhaA sodium-proton antiporter b0019 106 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 16131193 Common rpsC 30S ribosomal subunit protein S3 b3314 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 16129455 Common yddA fused predicted multidrug transporter subunits of ABC superfamily: membrane component/ATP-binding component b1496 197 COG4178 COG4178, ABC-type uncharacterized transport system, permease and ATPase components General function prediction only 16131959 Common cadC DNA-binding transcriptional activator b4133 86 COG3710 CadC, DNA-binding winged-HTH domains Transcription 16128568 Common fes enterobactin/ferric enterobactin esterase b0585 28 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 16131753 Common fieF zinc transporter b3915 209 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 16131598 Common glmU fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase b3730 235 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 16130561 Common ypjF CP4-57 prophage; toxin of the YpjF-YfjZ toxin-antitoxin system b2646 8 None None None 16128233 Common yafX CP4-6 prophage; predicted protein b0248 17 None None None 16128868 Common ycaK conserved protein b0901 76 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 16131812 Common nusG transcription termination factor b3982 215 COG0250 NusG, Transcription antiterminator Transcription 145698297 Nonpathogen yffQ CPZ-55 prophage; predicted protein b2448 1 None None None 16129892 Common fliM flagellar motor switching and energizing component b1945 110 COG1868 FliM, Flagellar motor switch protein Cell motility and secretion 16129652 Common ydiP predicted DNA-binding transcriptional regulator b1696 112 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16131683 Common yigP conserved protein b3834 30 COG3165 COG3165, Uncharacterized protein conserved in bacteria Function unknown 16129698 Common astE succinylglutamate desuccinylase b1744 25 COG2988 COG2988, Succinylglutamate desuccinylase Amino acid transport and metabolism 16129116 Common ymfQ e14 prophage; conserved protein b1153 16 COG3778 COG3778, Uncharacterized protein conserved in bacteria Function unknown 90111562 Common aaeX membrane protein of efflux system b3242 13 None None None 16129756 Common yeaW predicted 2Fe-2S cluster-containing protein b1802 89 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 16129780 Common mgrB predicted protein b1826 5 None None None 90111713 Common yjgK conserved protein b4252 30 COG2731 EbgC, Beta-galactosidase, beta subunit Carbohydrate transport and metabolism 16131194 Common rplV 50S ribosomal subunit protein L22 b3315 218 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 16129765 Common yoaH conserved protein b1811 16 COG3140 COG3140, Uncharacterized protein conserved in bacteria Function unknown 16128584 Common ybdM conserved protein b0601 17 COG1475 Spo0J, Predicted transcriptional regulators Transcription 16128520 Common intD DLP12 prophage; predicted integrase b0537 138 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 16129173 Common hemA glutamyl tRNA reductase b1210 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 16130626 Common hycG hydrogenase 3 and formate hydrogenase complex, HycG subunit b2719 192 COG3260 COG3260, Ni,Fe-hydrogenase III small subunit Energy production and conversion 16128366 Common ddlA D-alanine-D-alanine ligase A b0381 214 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 16130010 Common yegI conserved protein b2070 18 COG4248 COG4248, Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains General function prediction only 16130325 Common nupC nucleoside (except guanosine) transporter b2393 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 16131633 Common ppiC peptidyl-prolyl cis-trans isomerase C (rotamase C) b3775 142 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 16128383 Common sbcD exonuclease, dsDNA, ATP-dependent b0398 112 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 16131233 Common yheU conserved protein b3354 30 COG3089 COG3089, Uncharacterized protein conserved in bacteria Function unknown 90111339 Common yebQ predicted transporter b1828 219 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16128116 Common cueO multicopper oxidase (laccase) b0123 123 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 16131602 Common atpA F1 sector of membrane-bound ATP synthase, alpha subunit b3734 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 94541116 Common yoeB toxin of the YoeB-YefM toxin-antitoxin system b4539 53 COG4115 COG4115, Uncharacterized protein conserved in bacteria Function unknown 90111318 Common ydiO predicted acyl-CoA dehydrogenase b1695 158 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 16131184 Common rplF 50S ribosomal subunit protein L6 b3305 226 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 16130353 Common murQ predicted PTS component b2428 83 COG2103 COG2103, Predicted sugar phosphate isomerase General function prediction only 16129269 Common pspE thiosulfate:cyanide sulfurtransferase (rhodanese) b1308 77 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 16128935 Common yccX predicted acylphosphatase b0968 136 COG1254 AcyP, Acylphosphatases Energy production and conversion 16129476 Common lsrF putative autoinducer-2 (AI-2) aldolase b1517 77 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 16130740 Common aas fused 2-acylglycerophospho-ethanolamine acyl transferase/acyl-acyl carrier protein synthetase b2836 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 90111138 Common ylaB conserved inner membrane protein b0457 162 COG4943 COG4943, Predicted signal transduction protein containing sensor and EAL domains Signal transduction mechanisms 16130862 Common mutY adenine DNA glycosylase b2961 231 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 16130785 Common guaD guanine deaminase b2883 159 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 16131610 Common mioC FMN-binding protein MioC b3742 79 COG0716 FldA, Flavodoxins Energy production and conversion 16131178 Common rpmJ 50S ribosomal subunit protein L36 b3299 134 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 90111596 Common yhhS predicted transporter b3473 58 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 49176352 Common rtcA RNA 3'-terminal phosphate cyclase b4475 47 COG0430 RCL1, RNA 3'-terminal phosphate cyclase RNA processing and modification 16131731 Common fdhE formate dehydrogenase formation protein b3891 43 COG3058 FdhE, Uncharacterized protein involved in formate dehydrogenase formation Posttranslational modification, protein turnover, chaperones 49176371 Common hokA toxic polypeptide, small b4455 7 None None None 16131647 Common rffA TDP-4-oxo-6-deoxy-D-glucose transaminase b3791 201 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 90111292 Common ydfO Qin prophage; predicted protein b1549 4 COG5562 COG5562, Phage envelope protein General function prediction only 16131690 Common fre flavin reductase b3844 103 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 16131791 Common frwD predicted enzyme IIB component of PTS b3953 68 COG1445 FrwB, Phosphotransferase system fructose-specific component IIB Carbohydrate transport and metabolism 16128096 Common coaE dephospho-CoA kinase b0103 204 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 16129122 Common mcrA e14 prophage; 5-methylcytosine-specific restriction endonuclease B b1159 26 COG3183 COG3183, Predicted restriction endonuclease Defense mechanisms 16129494 Common ydeH conserved protein b1535 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 16129806 Common yebK predicted DNA-binding transcriptional regulator b1853 99 COG1737 RpiR, Transcriptional regulators Transcription 16131215 Common bfr bacterioferritin, iron storage and detoxification protein b3336 107 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 90111186 Common ycaL predicted peptidase with chaperone function b0909 130 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 16129943 Common yeeS CP4-44 prophage; predicted DNA repair protein b2002 173 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 16132144 Common uxuB D-mannonate oxidoreductase, NAD-binding b4323 90 COG0246 MtlD, Mannitol-1-phosphate/altronate dehydrogenases Carbohydrate transport and metabolism 90111583 Common hofM predicted pilus assembly protein b3395 10 COG4972 PilM, Tfp pilus assembly protein, ATPase PilM Cell motility and secretion / Intracellular trafficking and secretion 90111681 Common yjcB predicted inner membrane protein b4060 7 None None None 16131531 Common nlpA cytoplasmic membrane lipoprotein-28 b3661 100 COG1464 NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen Inorganic ion transport and metabolism 16128266 Common intF CP4-6 prophage; predicted phage integrase b0281 56 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 90111512 Common scpB methylmalonyl-CoA decarboxylase, biotin-independent b2919 177 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 16131339 Common yhhM conserved protein b3467 8 None None None 16131992 Common mutL methyl-directed mismatch repair protein b4170 191 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 16128373 Common aroL shikimate kinase II b0388 198 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 16130064 Common yehU predicted sensory kinase in two-component system with YehT b2126 105 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 49176392 Common dgoR predicted DNA-binding transcriptional regulator b4479 130 COG2186 FadR, Transcriptional regulators Transcription 16129828 Common argS arginyl-tRNA synthetase b1876 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 16131978 Common frdB fumarate reductase (anaerobic), Fe-S subunit b4153 208 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 145698288 Common arnB uridine 5'-(beta-1-threo-pentapyranosyl-4-ulose diphosphate) aminotransferase, PLP-dependent b2253 207 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 16132064 Common mgtA magnesium transporter b4242 232 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 16131366 Common uspB predicted universal stress (ethanol tolerance) protein B b3494 12 None None None 16131093 Common hpf predicted ribosome-associated, sigma 54 modulation protein b3203 138 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 16131883 Common yjbR conserved protein b4057 36 COG2315 MmcQ, Uncharacterized protein conserved in bacteria Function unknown 16131582 Common yieG predicted inner membrane protein b3714 134 COG2252 COG2252, Permeases General function prediction only 49176301 Common yqhG conserved protein b3013 4 None None None 90111198 Common etp phosphotyrosine-protein phosphatase b0982 126 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 16128821 Common ybjN predicted oxidoreductase b0853 13 None None None 16129062 Common holB DNA polymerase III, delta prime subunit b1099 184 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 16130894 Common hybC hydrogenase 2, large subunit b2994 108 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 16128003 Common mog predicted molybdochelatase b0009 184 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 90111191 Common ycbV predicted fimbrial-like adhesin protein b0943 11 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16131303 Common glgA glycogen synthase b3429 133 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 16129977 Common rfbX predicted polisoprenol-linked O-antigen transporter b2037 44 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 16131400 Common dctA C4-dicarboxylic acid, orotate and citrate transporter b3528 161 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 16128755 Common ybhM conserved inner membrane protein b0787 4 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 16128840 Common hcr HCP oxidoreductase, NADH-dependent b0872 126 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 49175991 Common hokC toxic membrane protein, small b4412 7 None None None 16128744 Common bioF 8-amino-7-oxononanoate synthase b0776 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 16131321 Common ugpQ glycerophosphodiester phosphodiesterase, cytosolic b3449 139 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 16129102 Nonpathogen lit e14 prophage; cell death peptidase, inhibitor of T4 late gene expression b1139 3 None None None 16129672 Common rplT 50S ribosomal subunit protein L20 b1716 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 16129076 Common ycfS conserved protein b1113 84 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 16128027 Common carB carbamoyl-phosphate synthase large subunit b0033 237 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 16131347 Common acpT holo-(acyl carrier protein) synthase 2 b3475 44 COG2091 Sfp, Phosphopantetheinyl transferase Coenzyme metabolism 16129051 Common yceD conserved protein b1088 55 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 16128091 Common secA preprotein translocase subunit, ATPase b0098 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 16130048 Common yehC predicted periplasmic pilin chaperone b2110 24 COG3121 FimC, P pilus assembly protein, chaperone PapD Cell motility and secretion / Intracellular trafficking and secretion 16128065 Common leuD 3-isopropylmalate isomerase subunit b0071 209 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 16130505 Common ung uracil-DNA-glycosylase b2580 128 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 16129523 Common relB Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/ transcriptional repressor b1564 13 COG3077 RelB, DNA-damage-inducible protein J DNA replication, recombination, and repair 16129850 Common araG fused L-arabinose transporter subunits of ABC superfamily: ATP-binding components b1900 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 16131949 Common dcuB C4-dicarboxylate antiporter b4123 36 COG2704 DcuB, Anaerobic C4-dicarboxylate transporter General function prediction only 16128071 Common ilvH acetolactate synthase III, thiamin-dependent, small subunit b0078 191 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 16130450 Common fdx [2Fe-2S] ferredoxin b2525 104 COG0633 Fdx, Ferredoxin Energy production and conversion 16129254 Common sapB predicted antimicrobial peptide transporter subunit b1293 218 COG4168 SapB, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 16129805 Common zwf glucose-6-phosphate dehydrogenase b1852 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 162135915 Common aidB isovaleryl CoA dehydrogenase b4187 138 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 16128080 Common mraY phospho-N-acetylmuramoyl-pentapeptide transferase b0087 213 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 16129528 Common dicC Qin prophage; DNA-binding transcriptional regulator for DicB b1569 3 None None None 16130021 Common yegQ predicted peptidase b2081 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 90111421 Common yfcZ conserved protein b2343 15 COG3691 COG3691, Uncharacterized protein conserved in bacteria Function unknown 16129419 Common ydcC conserved protein b1460 35 COG5433 COG5433, Transposase DNA replication, recombination, and repair 145698302 Common yfiM predicted protein b2586 12 COG5544 COG5544, Predicted periplasmic lipoprotein General function prediction only 16129817 Common yebC conserved protein b1864 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 16129306 Common intR Rac prophage; integrase b1345 91 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 16130430 Common yfgH predicted outer membrane lipoprotein b2505 4 COG3133 SlyB, Outer membrane lipoprotein Cell envelope biogenesis, outer membrane 16129348 Common maoC fused aldehyde dehydrogenase/enoyl-CoA hydratase b1387 219 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 16128834 Common ybjQ conserved protein b0866 97 COG0393 COG0393, Uncharacterized conserved protein Function unknown 16128625 Common leuS leucyl-tRNA synthetase b0642 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 49176193 Common yeiL DNA-binding transcriptional activator of stationary phase nitrogen survival b2163 17 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 16129585 Common rsxA predicted inner membrane subunit b1627 76 COG4657 RnfA, Predicted NADH:ubiquinone oxidoreductase, subunit RnfA Energy production and conversion 90111527 Common dkgA 2,5-diketo-D-gluconate reductase A b3012 188 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 16131365 Common pitA phosphate transporter, low-affinity b3493 150 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 16130043 Common rcnR conserved protein b2105 75 COG1937 COG1937, Uncharacterized protein conserved in bacteria Function unknown 16129591 Common nth DNA glycosylase and apyrimidinic (AP) lyase (endonuclease III) b1633 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 16129846 Common insA KpLE2 phage-like element; IS1 repressor protein InsA b1894 14 COG3677 COG3677, Transposase and inactivated derivatives DNA replication, recombination, and repair 16129241 Common yciM conserved protein b1280 73 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 16128471 Common cueR DNA-binding transcriptional activator of copper-responsive regulon genes b0487 143 COG0789 SoxR, Predicted transcriptional regulators Transcription 90111298 Nonpathogen ydfB Qin prophage; predicted protein b1572 1 None None None 16129679 Common yniA predicted phosphotransferase/kinase b1725 71 COG3001 COG3001, Uncharacterized protein conserved in bacteria Function unknown 16131735 Common fdhD formate dehydrogenase formation protein b3895 136 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 16128897 Common asnS asparaginyl tRNA synthetase b0930 236 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 90111438 Common eutG predicted alcohol dehydrogenase in ethanolamine utilization b2453 175 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 16131049 Common yhbT predicted lipid carrier protein b3157 33 COG3154 COG3154, Putative lipid carrier protein Lipid metabolism 16130809 Common ubiH 2-octaprenyl-6-methoxyphenol hydroxylase, FAD/NAD(P)-binding b2907 124 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 49176154 Common manZ mannose-specific enzyme IID component of PTS b1819 41 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 90111273 Common ydcP predicted peptidase b1435 140 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 16131952 Common yjdI conserved protein b4126 19 COG3592 COG3592, Uncharacterized conserved protein Function unknown 16129180 Common chaB predicted cation regulator b1217 22 COG4572 ChaB, Putative cation transport regulator General function prediction only 90111243 Common puuP putrescine importer b1296 187 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 16129873 Common fliT predicted chaperone b1926 10 None None None 49176312 Common yhaM conserved protein b4470 35 COG3681 COG3681, Uncharacterized conserved protein Function unknown 16129626 Common ydhU predicted cytochrome b1670 16 COG4117 COG4117, Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) Energy production and conversion 16132170 Common hsdM DNA methylase M b4349 158 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 90111293 Common gnsB Qin prophage; predicted protein b1550 2 None None None 16129260 Common puuR DNA-binding transcriptional repressor b1299 106 COG1396 HipB, Predicted transcriptional regulators Transcription 90111131 Common yajL conserved protein b0424 99 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 16129153 Common dadX alanine racemase 2, PLP-binding b1190 199 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 16128087 Common ftsA ATP-binding cell division protein involved in recruitment of FtsK to Z ring b0094 181 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 16131505 Common coaD pantetheine-phosphate adenylyltransferase b3634 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 16131126 Common mdh malate dehydrogenase, NAD(P)-binding b3236 179 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 94541128 Common yicS predicted protein b4555 5 None None None 16129218 Common yciE conserved protein b1257 24 COG3685 COG3685, Uncharacterized protein conserved in bacteria Function unknown 90111167 Common ybhJ predicted hydratase b0771 220 COG1048 AcnA, Aconitase A Energy production and conversion 16131208 Common gspH predicted general secretory pathway component, cryptic b3329 1 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 90111569 Common gspD general secretory pathway component, cryptic b3325 140 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 16129125 Common ycgE predicted DNA-binding transcriptional regulator b1162 63 COG0789 SoxR, Predicted transcriptional regulators Transcription 90111343 Common yebW predicted protein b1837 8 None None None 16130146 Common eco ecotin, a serine protease inhibitor b2209 23 COG4574 Eco, Serine protease inhibitor ecotin General function prediction only 16130590 Common nrdF ribonucleoside-diphosphate reductase 2, beta subunit, ferritin-like protein b2676 141 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 16128213 Common yafL predicted lipoprotein and C40 family peptidase b0227 127 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 16130768 Common xdhA xanthine dehydrogenase, molybdenum binding subunit b2866 117 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 16131807 Common birA bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase/ DNA-binding transcriptional repressor, bio-5'-AMP-binding b3973 231 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 16130343 Common crr glucose-specific enzyme IIA component of PTS b2417 60 COG2190 NagE, Phosphotransferase system IIA components Carbohydrate transport and metabolism 16130638 Common fhlA DNA-binding transcriptional activator b2731 173 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 94541101 Nonpathogen kdpF potassium ion accessory transporter subunit b4513 1 None None None 16131662 Common yigA conserved protein b3810 33 COG3159 COG3159, Uncharacterized protein conserved in bacteria Function unknown 16131905 Common fdhF formate dehydrogenase-H, selenopolypeptide subunit b4079 199 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 16129843 Common flhC DNA-binding transcriptional dual regulator with FlhD b1891 27 None None None 16131149 Common fis global DNA-binding transcriptional dual regulator b3261 97 COG2901 Fis, Factor for inversion stimulation Fis, transcriptional activator Transcription / DNA replication, recombination, and repair 90111378 Common yegH fused predicted membrane protein/predicted membrane protein b2063 219 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 16130439 Common hisS histidyl tRNA synthetase b2514 247 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 16130240 Common yfcI conserved protein b2305 28 COG5464 COG5464, Uncharacterized conserved protein Function unknown 90111637 Common ibpB heat shock chaperone b3686 67 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 16129680 Common yniB predicted inner membrane protein b1726 13 None None None 16129203 Common ychE predicted inner membrane protein b1242 159 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 16129867 Common fliY cystine transporter subunit b1920 186 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 16128177 Common dnaE DNA polymerase III alpha subunit b0184 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 16130156 Common atoS sensory histidine kinase in two-component regulatory system with AtoC b2219 223 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 16131050 Common yhbU predicted peptidase (collagenase-like) b3158 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 16130718 Common csdE predicted Fe-S metabolism protein b2811 94 COG2166 COG2166, SufE protein probably involved in Fe-S center assembly General function prediction only 16130405 Common bcp thiol peroxidase, thioredoxin-dependent b2480 216 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 16128258 Common argF CP4-6 prophage; ornithine carbamoyltransferase 2, chain F b0273 239 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 16131703 Common yihG predicted endonuclease b3862 31 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 16129318 Common ydaS Rac prophage; predicted DNA-binding transcriptional regulator b1357 9 COG4197 COG4197, Uncharacterized protein conserved in bacteria, prophage-related Function unknown 16129749 Common yeaQ conserved inner membrane protein b1795 40 COG2261 COG2261, Predicted membrane protein Function unknown 16130232 Common pta phosphate acetyltransferase b2297 168 COG0280 Pta, Phosphotransacetylase Energy production and conversion 16130483 Common yfhD predicted transglycosylase b2558 92 COG4623 COG4623, Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein Cell envelope biogenesis, outer membrane 16130467 Common hcaD phenylpropionate dioxygenase, ferredoxin reductase subunit b2542 207 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 16129060 Common yceG predicted aminodeoxychorismate lyase b1097 183 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 16129350 Common paaB predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation b1389 37 COG3460 COG3460, Uncharacterized enzyme of phenylacetate metabolism Secondary metabolites biosynthesis, transport, and catabolism 16130738 Common tas predicted oxidoreductase, NADP(H)-dependent aldo-keto reductase b2834 194 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 162135917 Common fecB KpLE2 phage-like element; iron-dicitrate transporter subunit b4290 87 COG4594 FecB, ABC-type Fe3+-citrate transport system, periplasmic component Inorganic ion transport and metabolism 90111555 Common yrbA predicted DNA-binding transcriptional regulator b3190 72 COG5007 COG5007, Predicted transcriptional regulator, BolA superfamily Transcription 16130452 Common hscB DnaJ-like molecular chaperone specific for IscU b2527 57 COG1076 DjlA, DnaJ-domain-containing proteins 1 Posttranslational modification, protein turnover, chaperones 16131803 Common trmA tRNA (uracil-5-)-methyltransferase b3965 178 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 90111330 Common yeaD conserved protein b1780 62 COG0676 COG0676, Uncharacterized enzymes related to aldose 1-epimerase Carbohydrate transport and metabolism 16129271 Common ycjN predicted sugar transporter subunit: periplasmic-binding component of ABC superfamily b1310 101 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 16129172 Common lolB chaperone for lipoproteins b1209 53 COG3017 LolB, Outer membrane lipoprotein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 90111222 Common ymfT e14 prophage; predicted DNA-binding transcriptional regulator b1146 2 None None None 16131540 Common ilvN acetolactate synthase I, small subunit b3670 124 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 94541109 Common ydaE Rac prophage; conserved protein b4526 3 None None None 16129811 Common znuC zinc transporter subunit: ATP-binding component of ABC superfamily b1858 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 90111387 Common yohN predicted protein b2107 10 COG5455 COG5455, Predicted integral membrane protein Function unknown 16128713 Common tolR membrane spanning protein in TolA-TolQ-TolR complex b0738 103 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 16130659 Common cysD sulfate adenylyltransferase, subunit 2 b2752 138 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 90111612 Common yhjY conserved protein b3548 10 COG5571 COG5571, Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion Cell motility and secretion 16129987 Common wcaJ predicted UDP-glucose lipid carrier transferase b2047 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 16129032 Common yceN predicted inner membrane protein b1069 193 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 16130745 Common araE arabinose transporter b2841 179 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 90111676 Common yjbF predicted lipoprotein b4027 13 None None None 145698234 Common ybhU hypothetical protein b4591 1 None None None 16128460 Common aes acetyl esterase b0476 110 COG0657 Aes, Esterase/lipase Lipid metabolism 16132007 Common yjfM conserved protein b4185 4 COG5463 COG5463, Predicted integral membrane protein Function unknown 16128435 Common glnK nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB b0450 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 16129469 Common ydeK predicted lipoprotein b1510 59 None None None 16129662 Common ydiU conserved protein b1706 110 COG0397 COG0397, Uncharacterized conserved protein Function unknown 16131244 Common nirB nitrite reductase, large subunit, NAD(P)H-binding b3365 195 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 16129288 Common ycjY predicted hydrolase b1327 59 COG1073 COG1073, Hydrolases of the alpha/beta superfamily General function prediction only 16130885 Common yghS predicted protein with nucleoside triphosphate hydrolase domain b2985 3 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 16131765 Common glpF glycerol facilitator b3927 134 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 145698232 Common ybfQ predicted transposase b4514 19 COG5433 COG5433, Transposase DNA replication, recombination, and repair 16128786 Common ybiR predicted transporter b0818 75 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 90111413 Common yfbL predicted peptidase b2271 36 COG2234 Iap, Predicted aminopeptidases General function prediction only 16128301 Common yahB predicted DNA-bindng transcriptional regulator b0316 151 COG0583 LysR, Transcriptional regulator Transcription 16129039 Common flgE flagellar hook protein b1076 126 COG1749 FlgE, Flagellar hook protein FlgE Cell motility and secretion 16131802 Common yijD conserved inner membrane protein b3964 15 None None None 16132105 Common insI KpLE2 phage-like element; IS30 transposase b4284 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 16131290 Common gntY predicted gluconate transport associated protein b3414 74 COG0694 COG0694, Thioredoxin-like proteins and domains Posttranslational modification, protein turnover, chaperones 16132076 Common argI ornithine carbamoyltransferase 1 b4254 238 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 16131019 Common garP predicted (D)-galactarate transporter b3127 184 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 145698239 Common yccW predicted methyltransferase b0967 142 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 16131494 Common waaU lipopolysaccharide core biosynthesis b3623 9 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 145698305 Common ygdT hypothetical protein b4610 2 None None None 16130107 Common fruB fused fructose-specific PTS enzymes: IIA component/HPr component b2169 120 COG4668 MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain Carbohydrate transport and metabolism 16130730 Common ppdA conserved protein b2826 10 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 49176422 Common rhtB neutral amino-acid efflux system b3824 117 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 16128250 Common insA KpLE2 phage-like element; IS1 repressor protein InsA b0265 14 COG3677 COG3677, Transposase and inactivated derivatives DNA replication, recombination, and repair 16131042 Common yraP predicted protein b3150 69 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 16128406 Common ispA geranyltranstransferase b0421 242 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 16129006 Common csgC predicted curli production protein b1043 5 None None None 90111142 Common ybbN predicted thioredoxin domain-containing protein b0492 214 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 16130208 Nonpathogen yfbN predicted protein b2273 2 None None None 16131065 Common secG preprotein translocase membrane subunit b3175 126 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 49176208 Common yfcE predicted phosphatase b2300 46 COG0622 COG0622, Predicted phosphoesterase General function prediction only 16131258 Common yhfW predicted mutase b3380 74 COG1015 DeoB, Phosphopentomutase Carbohydrate transport and metabolism 90111691 Common fxsA inner membrane protein b4140 14 COG3030 FxsA, Protein affecting phage T7 exclusion by the F plasmid General function prediction only 16130707 Common fucA L-fuculose-1-phosphate aldolase b2800 156 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 16129452 Common gadB glutamate decarboxylase B, PLP-dependent b1493 67 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 16131300 Common glpD sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding b3426 149 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 16131914 Common alsB D-allose transporter subunit b4088 104 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 49176428 Common tatB TatABCE protein translocation system subunit b3838 38 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 16128976 Common rutC conserved protein b1010 181 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 16130575 Common gabD succinate-semialdehyde dehydrogenase I, NADP-dependent b2661 221 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 145698279 Common flhD DNA-binding transcriptional dual regulator with FlhC b1892 27 None None None 16128990 Common insF IS3 element protein InsF b1026 149 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 16129124 Common ycgX predicted protein b1161 4 COG5562 COG5562, Phage envelope protein General function prediction only 16131522 Common trmH tRNA (Guanosine-2'-O-)-methyltransferase b3651 201 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 16131577 Common tnaB tryptophan transporter of low affinity b3709 32 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 16131499 Common rfaB UDP-D-galactose:(glucosyl)lipopolysaccharide-1,6-D-galactosyltransferase b3628 136 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 16131395 Common yhjE predicted transporter b3523 126 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 16131736 Common yiiG conserved protein b3896 8 None None None 16130305 Common oxc predicted oxalyl-CoA decarboxylase b2373 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 16131847 Common pepE (alpha)-aspartyl dipeptidase b4021 35 COG3340 PepE, Peptidase E Amino acid transport and metabolism 16131932 Common phnC phosphonate/organophosphate ester transporter subunit b4106 249 COG3638 COG3638, ABC-type phosphate/phosphonate transport system, ATPase component Inorganic ion transport and metabolism 16130333 Common xapA purine nucleoside phosphorylase II b2407 156 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 16129648 Common ydiB quinate/shikimate 5-dehydrogenase, NAD(P)-binding b1692 225 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 90111380 Common yegD predicted chaperone b2069 231 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 16128357 Common insF IS3 element protein InsF b0372 149 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 16131057 Common rpsO 30S ribosomal subunit protein S15 b3165 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 16130543 Common yfjI CP4-57 prophage; predicted protein b2625 23 None None None 16128676 Common rhsC rhsC element core protein RshC b0700 67 COG3209 RhsA, Rhs family protein Cell envelope biogenesis, outer membrane 16128839 Common poxB pyruvate dehydrogenase (pyruvate oxidase), thiamin-dependent, FAD-binding b0871 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 90111263 Common ydbL conserved protein b1383 31 COG3784 COG3784, Uncharacterized protein conserved in bacteria Function unknown 16130389 Common talA transaldolase A b2464 188 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 16129771 Common manX fused mannose-specific PTS enzymes: IIA component/IIB component b1817 88 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 16129556 Common ydgD predicted peptidase b1598 21 COG3591 COG3591, V8-like Glu-specific endopeptidase Amino acid transport and metabolism 90111181 Common ybjE predicted transporter b0874 49 COG2431 COG2431, Predicted membrane protein Function unknown 90111211 Common yceF predicted protein b1087 194 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 90111316 Common ydiL conserved protein b1689 4 None None None 16129416 Common ydcD predicted protein b1457 1 None None None 16130471 Common yphD predicted sugar transporter subunit: membrane component of ABC superfamily b2546 114 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 16131089 Common yrbK conserved protein b3199 25 COG3117 COG3117, Uncharacterized protein conserved in bacteria Function unknown 16131091 Common lptB predicted transporter subunit: ATP-binding component of ABC superfamily b3201 249 COG1137 YhbG, ABC-type (unclassified) transport system, ATPase component General function prediction only 16128761 Common ybhS predicted transporter subunit: membrane component of ABC superfamily b0793 130 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 16129714 Common ynjH predicted protein b1760 8 None None None 145698223 Common mhpR DNA-binding transcriptional activator, 3HPP-binding b0346 92 COG1414 IclR, Transcriptional regulator Transcription 16131342 Common sirA conserved protein required for cell growth b3470 102 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 16131891 Common yjcE predicted cation/proton antiporter b4065 108 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 16131536 Common uhpT hexose phosphate transporter b3666 47 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 16128120 Common yadG predicted transporter subunit: ATP-binding component of ABC superfamily b0127 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 90111505 Common yqeC conserved protein b2876 20 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 145698350 Nonpathogen ytjA predicted protein b4568 1 COG5487 COG5487, Small integral membrane protein Function unknown 16129402 Common ydcV predicted spermidine/putrescine transporter subunit b1443 120 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 16128904 Common ssuE NAD(P)H-dependent FMN reductase b0937 55 COG0431 COG0431, Predicted flavoprotein General function prediction only 16131288 Common bioH carboxylesterase of pimeloyl-CoA synthesis b3412 141 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 16129984 Common wcaL predicted glycosyl transferase b2044 212 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 16128947 Common etk cryptic autophosphorylating protein tyrosine kinase Etk b0981 154 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 16130757 Common ygeI predicted protein b2853 1 None None None 16128132 Common htrE predicted outer membrane usher protein b0139 29 COG3188 FimD, P pilus assembly protein, porin PapC Cell motility and secretion / Intracellular trafficking and secretion 16128989 Common ycdT predicted diguanylate cyclase b1025 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 16130264 Common aroC chorismate synthase b2329 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 16128122 Common yadI predicted PTS Enzyme IIA b0129 44 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 16129932 Common cobT nicotinate-nucleotide dimethylbenzimidazole-P phophoribosyl transferase b1991 119 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 16128929 Common helD DNA helicase IV b0962 228 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 16131280 Common pck phosphoenolpyruvate carboxykinase b3403 96 COG1866 PckA, Phosphoenolpyruvate carboxykinase (ATP) Energy production and conversion 16128015 Common insB IS1 transposase InsAB' b0021 20 COG1662 InsB, Transposase and inactivated derivatives, IS1 family DNA replication, recombination, and repair 16130794 Common recJ ssDNA exonuclease, 5' --> 3'-specific b2892 192 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 16130965 Common yqjH predicted siderophore interacting protein b3070 60 COG2375 ViuB, Siderophore-interacting protein Inorganic ion transport and metabolism 90111252 Common abgA predicted peptidase, aminobenzoyl-glutamate utilization protein b1338 162 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 16129730 Common ydjL predicted oxidoreductase, Zn-dependent and NAD(P)-binding b1776 210 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 16130646 Common ygbM conserved protein b2739 76 COG3622 Hfi, Hydroxypyruvate isomerase Carbohydrate transport and metabolism 16129140 Common ycgJ predicted protein b1177 9 None None None 16130110 Common yeiQ predicted dehydrogenase, NAD-dependent b2172 90 COG0246 MtlD, Mannitol-1-phosphate/altronate dehydrogenases Carbohydrate transport and metabolism 90111431 Common ucpA predicted oxidoredutase, sulfate metabolism protein b2426 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 90111175 Common yliJ predicted glutathione S-transferase b0838 95 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 49176413 Common rffT TDP-Fuc4NAc:lipidIIFuc4NAc transferase b4481 17 None None None 16132202 Common yjjJ predicted DNA-binding transcriptional regulator b4385 13 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 16129967 Common hisI fused phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase b2026 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 16131502 Common rfaG glucosyltransferase I b3631 169 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 16129256 Common ymjA predicted protein b1295 5 None None None 90111308 Common ydgK conserved inner membrane protein b1626 9 None None None 145698259 Common yncB predicted oxidoreductase, Zn-dependent and NAD(P)-binding b1449 102 COG2130 COG2130, Putative NADP-dependent oxidoreductases General function prediction only 16130313 Common ypdB predicted response regulator in two-component system withYpdA b2381 171 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 16129068 Common ycfM predicted outer membrane lipoprotein b1105 21 COG3417 FlgN, Collagen-binding surface adhesin SpaP (antigen I/II family) General function prediction only 16131183 Common rplR 50S ribosomal subunit protein L18 b3304 209 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 16128063 Common sgrR DNA-binding transcriptional regulator b0069 81 COG4533 COG4533, ABC-type uncharacterized transport system, periplasmic component General function prediction only 16131159 Common yhdZ predicted amino-acid transporter subunit b3271 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 16131584 Common cbrB predicted inner membrane protein b3716 4 None None None 16132087 Common idnT L-idonate and D-gluconate transporter b4265 79 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 16130526 Common yfiB predicted outer membrane lipoprotein b2605 143 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 16128617 Common mrdB cell wall shape-determining protein b0634 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 16129737 Common yeaG conserved protein with nucleoside triphosphate hydrolase domain b1783 71 COG2766 PrkA, Putative Ser protein kinase Signal transduction mechanisms 16130531 Common ffh Signal Recognition Particle (SRP) component with 4.5S RNA (ffs) b2610 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 16128325 Common cynS cyanate aminohydrolase b0340 41 COG1513 CynS, Cyanate lyase Inorganic ion transport and metabolism 16131082 Common yrbC predicted ABC-type organic solvent transporter b3192 80 COG2854 Ttg2D, ABC-type transport system involved in resistance to organic solvents, auxiliary component Secondary metabolites biosynthesis, transport, and catabolism 16128922 Common ycbZ predicted peptidase b0955 115 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 90111154 Common citC citrate lyase synthetase b0618 25 COG3053 CitC, Citrate lyase synthetase Energy production and conversion 16130320 Common glk glucokinase b2388 91 COG0837 Glk, Glucokinase Carbohydrate transport and metabolism 16129025 Common pyrC dihydro-orotase b1062 86 COG0418 PyrC, Dihydroorotase Nucleotide transport and metabolism 16128566 Common entD phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex b0583 25 COG2977 EntD, Phosphopantetheinyl transferase component of siderophore synthetase Secondary metabolites biosynthesis, transport, and catabolism 16130514 Common yfiH conserved protein b2593 181 COG1496 COG1496, Uncharacterized conserved protein Function unknown 16129836 Common cheR chemotaxis regulator, protein-glutamate methyltransferase b1884 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 16129355 Common paaG acyl-CoA hydratase b1394 179 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 16130129 Common insH IS5 transposase and trans-activator b2192 37 COG3039 COG3039, Transposase and inactivated derivatives, IS5 family DNA replication, recombination, and repair 16128004 Common yaaH conserved inner membrane protein associated with acetate transport b0010 50 COG1584 COG1584, Predicted membrane protein Function unknown 16132153 Common yjiJ predicted inner membrane protein b4332 59 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16129324 Common trkG Rac prophage; potassium transporter subunit b1363 129 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 16131175 Common rpsD 30S ribosomal subunit protein S4 b3296 217 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 16128281 Common ykgM rpmJ (L36) paralog b0296 107 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 145698252 Common yciZ hypothetical protein b4596 6 None None None 16130607 Common ygaD conserved protein b2700 191 COG1546 CinA, Uncharacterized protein (competence- and mitomycin-induced) General function prediction only 16130808 Common visC predicted oxidoreductase with FAD/NAD(P)-binding domain b2906 135 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 16130032 Common gatA galactitol-specific enzyme IIA component of PTS b2094 16 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 90111087 Common yacC predicted protein b0122 11 None None None 16130071 Common dld D-lactate dehydrogenase, FAD-binding, NADH independent b2133 62 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 16128378 Common rdgC DNA-binding protein, non-specific b0393 53 COG2974 RdgC, DNA recombination-dependent growth factor C DNA replication, recombination, and repair 94541097 Common ylcG DLP12 prophage; predicted protein b4509 3 None None None 90111472 Common yfjS CP4-57 prophage; predicted protein b2636 2 COG2378 COG2378, Predicted transcriptional regulator Transcription 16131224 Common yheN predicted intracellular sulfur oxidation protein b3345 42 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 16130814 Common serA D-3-phosphoglycerate dehydrogenase b2913 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 16128792 Common ybiY predicted pyruvate formate lyase activating enzyme b0824 60 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 90111741 Common mdoB phosphoglycerol transferase I b4359 46 COG1368 MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily Cell envelope biogenesis, outer membrane 16131530 Common yicL predicted inner membrane protein b3660 47 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 90111441 Common ypfH predicted hydrolase b2473 51 COG0400 COG0400, Predicted esterase General function prediction only 16130548 Common rnlA CP4-57 prophage; RNase LS b2630 4 None None None 49176132 Common ydhC predicted transporter b1660 206 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 90111540 Common yhaL predicted protein b3107 4 None None None 90111203 Common rutB predicted enzyme b1011 114 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 16130120 Common bcr bicyclomycin/multidrug efflux system b2182 165 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16128144 Common fhuC iron-hydroxamate transporter subunit b0151 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 16131912 Common alsC D-allose transporter subunit b4086 122 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 16128108 Common aceF pyruvate dehydrogenase, dihydrolipoyltransacetylase component E2 b0115 197 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 16128315 Common prpR DNA-binding transcriptional activator b0330 171 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 16131550 Common yidL predicted DNA-binding transcriptional regulator b3680 4 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16131333 Common rpoH RNA polymerase, sigma 32 (sigma H) factor b3461 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 16131435 Common xylB xylulokinase b3564 181 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 49176446 Common ptsA fused predicted PTS enzymes: Hpr component/enzyme I component/enzyme IIA component b3947 233 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 94541122 Common ypfN predicted protein b4547 11 None None None 16129439 Common sra 30S ribosomal subunit protein S22 b1480 5 None None None 162135895 Common psiF conserved protein b0384 22 None None None 90111605 Common yhjH EAL domain containing protein involved in flagellar function b3525 127 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 49176294 Common glcF glycolate oxidase iron-sulfur subunit b4467 175 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 16131277 Common hslR ribosome-associated heat shock protein Hsp15 b3400 107 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 16131547 Common yidI predicted inner membrane protein b3677 3 None None None 16129281 Common ycjW predicted DNA-binding transcriptional regulator b1320 126 COG1609 PurR, Transcriptional regulators Transcription 90111329 Common yeaC conserved protein b1777 28 COG3139 COG3139, Uncharacterized protein conserved in bacteria Function unknown 90111480 Common gutQ predicted phosphosugar-binding protein b2708 149 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 16128150 Common yadS conserved inner membrane protein b0157 129 COG2860 COG2860, Predicted membrane protein Function unknown 16131482 Common yibN predicted rhodanese-related sulfurtransferase b3611 99 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 16128719 Common pnuC predicted nicotinamide mononucleotide transporter b0751 62 COG3201 PnuC, Nicotinamide mononucleotide transporter Coenzyme metabolism 90111328 Common ydjH predicted kinase b1772 198 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 90111489 Common ygcW predicted deoxygluconate dehydrogenase b2774 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 16131523 Common recG ATP-dependent DNA helicase b3652 210 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 145698295 Common intZ CPZ-55 prophage; predicted integrase b2442 107 COG0582 XerC, Integrase DNA replication, recombination, and repair 16130294 Common yfdS CPS-53 (KpLE1) prophage; predicted protein b2362 3 None None None 49176450 Common nudC NADH pyrophosphatase b3996 108 COG2816 NPY1, NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding DNA replication, recombination, and repair 16130797 Common fldB flavodoxin 2 b2895 67 COG0716 FldA, Flavodoxins Energy production and conversion 16131446 Common yiaK 2,3-diketo-L-gulonate dehydrogenase, NADH-dependent b3575 67 COG2055 COG2055, Malate/L-lactate dehydrogenases Energy production and conversion 16128451 Common priC primosomal replication protein N'' b0467 14 COG3923 PriC, Primosomal replication protein N'' DNA replication, recombination, and repair 16128469 Common ybaS predicted glutaminase b0485 72 COG2066 GlsA, Glutaminase Amino acid transport and metabolism 16131279 Common yhgE predicted inner membrane protein b3402 16 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 49176408 Common gpp guanosine pentaphosphatase/exopolyphosphatase b3779 181 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 16131388 Common gadX DNA-binding transcriptional dual regulator b3516 17 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16130675 Common ygcP predicted anti-terminator regulatory protein b2768 26 COG1954 GlpP, Glycerol-3-phosphate responsive antiterminator (mRNA-binding) Transcription 16128655 Common nagE fused N-acetyl glucosamine specific PTS enzyme: IIC, IIB , and IIA components b0679 60 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 16131430 Common glyS glycine tRNA synthetase, beta subunit b3559 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 16129097 Common nudJ bifunctional thiamin pyrimidine pyrophosphate hydrolase/ thiamin pyrophosphate hydrolase b1134 66 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 145698261 Common yddM predicted DNA-binding transcriptional regulator b1477 59 COG3093 VapI, Plasmid maintenance system antidote protein General function prediction only 16129401 Common ydcU predicted spermidine/putrescine transporter subunit b1442 215 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 16131162 Common aroE dehydroshikimate reductase, NAD(P)-binding b3281 220 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 16128924 Common ompA outer membrane protein A (3a;II*;G;d) b0957 148 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 16129141 Common ycgK predicted protein b1178 8 None None None 16128677 Common ybfB predicted inner membrane protein b0702 1 None None None 16130513 Common clpB protein disaggregation chaperone b2592 217 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 16131070 Common yhbY predicted RNA-binding protein b3180 98 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 145698315 Common garR tartronate semialdehyde reductase b3125 177 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 90111327 Common pncA nicotinamidase/pyrazinamidase b1768 128 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 16128452 Common ybaN conserved inner membrane protein b0468 67 COG2832 COG2832, Uncharacterized protein conserved in bacteria Function unknown 16130250 Common folC bifunctional folylpolyglutamate synthase/ dihydrofolate synthase b2315 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 90111444 Common hyfA hydrogenase 4, 4Fe-4S subunit b2481 143 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 16128551 Common nfrA bacteriophage N4 receptor, outer membrane subunit b0568 9 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 16130004 Common asmA predicted assembly protein b2064 42 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 16128423 Common clpX ATPase and specificity subunit of ClpX-ClpP ATP-dependent serine protease b0438 233 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 16128455 Common ybaB conserved protein b0471 103 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 90111201 Common rutG predicted transporter b1006 129 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 16128039 Common yaaU predicted transporter b0045 163 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 90111208 Common msyB predicted protein b1051 7 None None None 16129561 Common pntA pyridine nucleotide transhydrogenase, alpha subunit b1603 166 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 16129764 Common yoaC predicted protein b1810 6 None None None 16129138 Common minD membrane ATPase of the MinC-MinD-MinE system b1175 148 COG2894 MinD, Septum formation inhibitor-activating ATPase Cell division and chromosome partitioning 145698332 Common rffC TDP-fucosamine acetyltransferase b3790 14 None None None 16128886 Common ycbJ conserved protein b0919 10 None None None 16130330 Common gltX glutamyl-tRNA synthetase b2400 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 16128956 Common cspG DNA-binding transcriptional regulator b0990 179 COG1278 CspC, Cold shock proteins Transcription 90111354 Common uvrC excinuclease UvrABC, endonuclease subunit b1913 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 90111315 Common sufB component of SufBCD complex b1683 186 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 16130507 Common trxC thioredoxin 2 b2582 233 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 90111481 Common norR DNA-binding transcriptional activator b2709 170 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 16129007 Common ymdA predicted protein b1044 5 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16131444 Common ysaA predicted hydrogenase, 4Fe-4S ferredoxin-type component b3573 151 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 16129715 Common gdhA glutamate dehydrogenase, NADP-specific b1761 175 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 16130082 Common sanA predicted protein b2144 41 COG2949 SanA, Uncharacterized membrane protein Function unknown 16131808 Common coaA pantothenate kinase b3974 73 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 16131287 Common yhgA predicted transposase b3411 27 COG5464 COG5464, Uncharacterized conserved protein Function unknown 16129189 Common narJ molybdenum-cofactor-assembly chaperone subunit (delta subunit) of nitrate reductase 1 b1226 54 COG2180 NarJ, Nitrate reductase delta subunit Energy production and conversion 90111133 Common yajR predicted transporter b0427 223 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16128942 Common hyaE protein involved in processing of HyaA and HyaB proteins b0976 10 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 16131733 Common fdoH formate dehydrogenase-O, Fe-S subunit b3893 162 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 94541126 Common ysaB predicted protein b4553 6 None None None 49176370 Common yiaD predicted outer membrane lipoprotein b3552 167 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 16130693 Common barA hybrid sensory histidine kinase, in two-component regulatory system with UvrY b2786 226 COG4999 COG4999, Uncharacterized domain of BarA-like signal transduction histidine kinases Signal transduction mechanisms 16128657 Common ybfM predicted outer membrane porin b0681 14 None None None 16131918 Common phnP carbon-phosphorus lyase complex accessory protein b4092 46 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 145698263 Common yneM hypothetical protein b4599 2 None None None 16131336 Common ftsY fused Signal Recognition Particle (SRP) receptor: membrane binding protein/conserved protein b3464 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 16131708 Common glnG fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein b3868 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 16128563 Common ybdJ predicted inner membrane protein b0580 6 None None None 16130121 Common rsuA 16S rRNA pseudouridylate 516 synthase b2183 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 16128616 Common rlpA minor lipoprotein b0633 135 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 16131487 Common tdh threonine 3-dehydrogenase, NAD(P)-binding b3616 209 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 16131088 Common kdsC 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase b3198 106 COG1778 COG1778, Low specificity phosphatase (HAD superfamily) General function prediction only 16128479 Common ybbA predicted transporter subunit: ATP-binding component of ABC superfamily b0495 249 COG4181 COG4181, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 145698221 Common yafY CP4-6 prophage; predicted DNA-binding transcriptional regulator b0251 2 None None None 16128945 Common appB cytochrome bd-II oxidase, subunit II b0979 156 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 16130037 Common yegU predicted hydrolase b2099 62 COG1397 DraG, ADP-ribosylglycohydrolase Posttranslational modification, protein turnover, chaperones 16128660 Common fldA flavodoxin 1 b0684 74 COG0716 FldA, Flavodoxins Energy production and conversion 16129253 Common sapC predicted antimicrobial peptide transporter subunit b1292 212 COG4171 SapC, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 16129888 Common fliI flagellum-specific ATP synthase b1941 247 COG1157 FliI, Flagellar biosynthesis/type III secretory pathway ATPase Cell motility and secretion / Intracellular trafficking and secretion 16131297 Common glpR DNA-binding transcriptional repressor b3423 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 145698348 Common yjjB conserved inner membrane protein b4363 34 COG3610 COG3610, Uncharacterized conserved protein Function unknown 16128390 Common queA S-adenosylmethionine:tRNA ribosyltransferase-isomerase b0405 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 90111102 Common yafZ CP4-6 prophage; conserved protein b0252 23 None None None 16132218 Common arcA DNA-binding response regulator in two-component regulatory system with ArcB or CpxA b4401 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 16128104 Common ampE predicted inner membrane protein b0111 17 COG3725 AmpE, Membrane protein required for beta-lactamase induction Defense mechanisms 16132142 Common gntP fructuronate transporter b4321 89 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 16129165 Common ycgV predicted adhesin b1202 48 COG3468 AidA, Type V secretory pathway, adhesin AidA Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 16130093 Common cirA ferric iron-catecholate outer membrane transporter b2155 131 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 49176442 Common sodA superoxide dismutase, Mn b3908 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 16129750 Common yoaG predicted protein b1796 5 None None None 16128763 Common ybhG predicted membrane fusion protein (MFP) component of efflux pump, membrane anchor b0795 144 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 16128870 Common pflB pyruvate formate lyase I b0903 58 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 16130444 Common pbpC fused transglycosylase/transpeptidase b2519 200 COG4953 PbpC, Membrane carboxypeptidase/penicillin-binding protein PbpC Cell envelope biogenesis, outer membrane 16131546 Common yidH conserved inner membrane protein b3676 19 COG2149 COG2149, Predicted membrane protein Function unknown 16128303 Common yahD predicted transcriptional regulator with ankyrin domain b0318 83 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 90111153 Common citE citrate lyase, citryl-ACP lyase (beta) subunit b0616 110 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 16131186 Common rpsN 30S ribosomal subunit protein S14 b3307 209 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 16130216 Common nuoI NADH:ubiquinone oxidoreductase, chain I b2281 191 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 16130132 Common ccmG periplasmic thioredoxin of cytochrome c-type biogenesis b2195 107 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 16128851 Common infA translation initiation factor IF-1 b0884 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 16128044 Common apaG protein associated with Co2+ and Mg2+ efflux b0050 89 COG2967 ApaG, Uncharacterized protein affecting Mg2+/Co2+ transport Inorganic ion transport and metabolism 90111234 Common dhaR predicted DNA-binding transcriptional regulator, dihydroxyacetone b1201 172 COG3284 AcoR, Transcriptional activator of acetoin/glycerol metabolism Secondary metabolites biosynthesis, transport, and catabolism / Transcription 16128127 Common panB 3-methyl-2-oxobutanoate hydroxymethyltransferase b0134 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 16128129 Common yadK predicted fimbrial-like adhesin protein b0136 4 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 90111086 Common yacL conserved protein b0119 21 COG3112 COG3112, Uncharacterized protein conserved in bacteria Function unknown 16128937 Common yccA inner membrane protein b0970 129 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 16130135 Common ccmD cytochrome c biogenesis protein b2198 4 COG3114 CcmD, Heme exporter protein D Intracellular trafficking and secretion 16131761 Common uspD stress-induced protein b3923 24 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 49176303 Common ygiV predicted transcriptional regulator b3023 33 COG3449 COG3449, DNA gyrase inhibitor DNA replication, recombination, and repair 49176432 Common trkH potassium transporter b3849 149 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 16130603 Common csrA pleiotropic regulatory protein for carbon source metabolism b2696 81 COG1551 CsrA, Carbon storage regulator (could also regulate swarming and quorum sensing) Signal transduction mechanisms 16129826 Common torY TMAO reductase III (TorYZ), cytochrome c-type subunit b1873 47 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 90111112 Common ykgC predicted oxidoreductase with FAD/NAD(P)-binding domain and dimerization domain b0304 238 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 16129011 Common mdoG glucan biosynthesis protein, periplasmic b1048 50 COG3131 MdoG, Periplasmic glucans biosynthesis protein Inorganic ion transport and metabolism 16130196 Common menC o-succinylbenzoyl-CoA synthase b2261 71 COG1441 MenC, O-succinylbenzoate synthase Coenzyme metabolism 16130521 Common tyrA fused chorismate mutase T/prephenate dehydrogenase b2600 85 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 16130126 Common yejM predicted hydrolase, inner membrane b2188 30 COG3083 COG3083, Predicted hydrolase of alkaline phosphatase superfamily General function prediction only 16130319 Common fryB predicted enzyme IIB component of PTS b2387 66 COG1445 FrwB, Phosphotransferase system fructose-specific component IIB Carbohydrate transport and metabolism 16129986 Common wzxC colanic acid exporter b2046 110 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 90111507 Common ygfO predicted transporter b2882 126 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 49176377 Common yiaY predicted Fe-containing alcohol dehydrogenase b3589 175 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 16129952 Common sbcB exonuclease I b2011 51 COG2925 SbcB, Exonuclease I DNA replication, recombination, and repair 16128987 Common pgaB predicted enzyme associated with biofilm formation b1023 71 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 16131384 Common gadE DNA-binding transcriptional activator b3512 2 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 16128465 Common ybaK conserved protein b0481 112 COG2606 EbsC, Uncharacterized conserved protein Function unknown 16132066 Common pyrI aspartate carbamoyltransferase, regulatory subunit b4244 64 COG1781 PyrI, Aspartate carbamoyltransferase, regulatory subunit Nucleotide transport and metabolism 16129086 Common potD polyamine transporter subunit b1123 140 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 16128130 Common yadL predicted fimbrial-like adhesin protein b0137 4 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16130407 Common hyfB hydrogenase 4, membrane subunit b2482 209 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 16131848 Common rluF 23S rRNA pseudouridine synthase b4022 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 16131461 Common selB selenocysteinyl-tRNA-specific translation factor b3590 249 COG3276 SelB, Selenocysteine-specific translation elongation factor Translation, ribosomal structure and biogenesis 16129150 Common fadR DNA-binding transcriptional dual regulator of fatty acid metabolism b1187 62 COG2186 FadR, Transcriptional regulators Transcription 16130022 Common ogrK DNA-binding transcriptional regulator prophage P2 remnant b2082 10 None None None 16129175 Common prmC N5-glutamine methyltransferase, modifies release factors RF-1 and RF-2 b1212 213 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 16132124 Common sgcQ KpLE2 phage-like element; predicted nucleoside triphosphatase b4303 40 COG0434 SgcQ, Predicted TIM-barrel enzyme General function prediction only 16130477 Common hmp fused nitric oxide dioxygenase/dihydropteridine reductase 2 b2552 134 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 16131998 Common yjeT conserved inner membrane protein b4176 9 COG3242 COG3242, Uncharacterized protein conserved in bacteria Function unknown 16129094 Common purB adenylosuccinate lyase b1131 229 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 16128966 Common cbpA curved DNA-binding protein, DnaJ homologue that functions as a co-chaperone of DnaK b1000 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 16130205 Common yfbK conserved protein b2270 54 COG2304 COG2304, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 16128715 Common tolB periplasmic protein b0740 157 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 16131935 Common yjdA conserved protein with nucleoside triphosphate hydrolase domain b4109 12 COG1160 COG1160, Predicted GTPases General function prediction only 16129359 Common paaK phenylacetyl-CoA ligase b1398 115 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 16128650 Common asnB asparagine synthetase B b0674 157 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 90111454 Common csiE stationary phase inducible protein b2535 11 COG3711 BglG, Transcriptional antiterminator Transcription 49176330 Common yhdP conserved membrane protein, predicted transporter b4472 56 COG3164 COG3164, Predicted membrane protein Function unknown 16130643 Common ygbJ predicted dehydrogenase, with NAD(P)-binding Rossmann-fold domain b2736 158 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 16130672 Common sscR 6-pyruvoyl tetrahydrobiopterin synthase (PTPS) b2765 127 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 16129320 Common ydaU Rac prophage; conserved protein b1359 13 COG3756 COG3756, Uncharacterized protein conserved in bacteria Function unknown 16131111 Common yhcH conserved protein b3221 30 COG2731 EbgC, Beta-galactosidase, beta subunit Carbohydrate transport and metabolism 90111672 Common thiF thiamin (thiazole moiety) biosynthesis protein b3992 223 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 16130152 Common ompC outer membrane porin protein C b2215 25 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 16131578 Common mdtL multidrug efflux system protein b3710 212 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16129411 Common yncE conserved protein b1452 51 COG3391 COG3391, Uncharacterized conserved protein Function unknown 16131571 Common rpmH 50S ribosomal subunit protein L34 b3703 109 COG0230 RpmH, Ribosomal protein L34 Translation, ribosomal structure and biogenesis 16128916 Common uup fused predicted transporter subunits of ABC superfamily: ATP-binding components b0949 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 94541100 Common ybdD conserved protein b4512 27 COG2879 COG2879, Uncharacterized small protein Function unknown 16131754 Common pfkA 6-phosphofructokinase I b3916 160 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 16130735 Common mutH methyl-directed mismatch repair protein b2831 28 COG3066 MutH, DNA mismatch repair protein DNA replication, recombination, and repair 90111348 Common yecD predicted hydrolase b1867 124 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 145698291 Common nuoC NADH:ubiquinone oxidoreductase, chain C,D b2286 191 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 90111633 Common uhpB sensory histidine kinase in two-component regulatory sytem with UhpA b3668 107 COG3851 UhpB, Signal transduction histidine kinase, glucose-6-phosphate specific Signal transduction mechanisms 90111300 Common ynfD predicted protein b1586 11 None None None 16129840 Common cheA fused chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY: sensory histidine kinase/signal sensing protein b1888 152 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 90111214 Common ycfQ predicted DNA-binding transcriptional regulator b1111 103 COG1309 AcrR, Transcriptional regulator Transcription 16129557 Common mdtI multidrug efflux system transporter b1599 108 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 16128183 Common yaeQ conserved protein b0190 52 COG4681 COG4681, Uncharacterized protein conserved in bacteria Function unknown 16129236 Common cysB DNA-binding transcriptional dual regulator, O-acetyl-L-serine-binding b1275 190 COG0583 LysR, Transcriptional regulator Transcription 16128395 Common yajD conserved protein b0410 26 None None None 16130168 Common yfaL adhesin b2233 83 COG3468 AidA, Type V secretory pathway, adhesin AidA Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 16131223 Common yheM predicted intraceullular sulfur oxidation protein b3344 35 COG2923 DsrF, Uncharacterized protein involved in the oxidation of intracellular sulfur Inorganic ion transport and metabolism 145698251 Common yciX hypothetical protein b4523 3 None None None 90111603 Common slp outer membrane lipoprotein b3506 30 COG3065 Slp, Starvation-inducible outer membrane lipoprotein Cell envelope biogenesis, outer membrane 16130560 Common yfjZ CP4-57 prophage; antitoxin of the YpjF-YfjZ toxin-antitoxin system b2645 10 None None None 49176025 Common ybaY predicted outer membrane lipoprotein b0453 29 COG3126 COG3126, Uncharacterized protein conserved in bacteria Function unknown 16132191 Common rimI acetylase for 30S ribosomal subunit protein S18 b4373 204 COG0456 RimI, Acetyltransferases General function prediction only 90111727 Common yjhT conserved protein b4310 21 COG3055 COG3055, Uncharacterized protein conserved in bacteria Function unknown 16128167 Common ispU undecaprenyl pyrophosphate synthase b0174 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 16129957 Common yeeZ predicted epimerase, with NAD(P)-binding Rossmann-fold domain b2016 97 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 16130654 Common ispD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase b2747 196 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 16128259 Common insB IS1 transposase InsAB' b0274 21 COG1662 InsB, Transposase and inactivated derivatives, IS1 family DNA replication, recombination, and repair 162135894 Common frmR regulator protein that represses frmRAB operon b0357 69 COG1937 COG1937, Uncharacterized protein conserved in bacteria Function unknown 16130915 Common parC DNA topoisomerase IV, subunit A b3019 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 16128405 Common dxs 1-deoxyxylulose-5-phosphate synthase, thiamine-requiring, FAD-requiring b0420 227 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 49176089 Common ldrC toxic polypeptide, small b4423 3 None None None 16130158 Common atoD acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit b2221 103 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 16129885 Common fliF flagellar basal-body MS-ring and collar protein b1938 126 COG1766 FliF, Flagellar biosynthesis/type III secretory pathway lipoprotein Cell motility and secretion / Intracellular trafficking and secretion 16129067 Common ycfL predicted protein b1104 10 COG5633 COG5633, Predicted periplasmic lipoprotein General function prediction only 16132198 Common deoC 2-deoxyribose-5-phosphate aldolase, NAD(P)-linked b4381 138 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 16130554 Common yfjT CP4-57 prophage; predicted protein b2637 2 None None None 145698273 Common fadK short chain acyl-CoA synthetase, anaerobic b1701 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 16129190 Common narI nitrate reductase 1, gamma (cytochrome b(NR)) subunit b1227 58 COG2181 NarI, Nitrate reductase gamma subunit Energy production and conversion 16130941 Common insD KpLE2 phage-like element; IS2 insertion element transposase InsAB' b3045 92 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 49176129 Common slyB outer membrane lipoprotein b1641 22 COG3133 SlyB, Outer membrane lipoprotein Cell envelope biogenesis, outer membrane 16131246 Common cysG fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase b3368 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 16131421 Common yiaC predicted acyltransferase with acyl-CoA N-acyltransferase domain b3550 50 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 90111556 Common yrbB predicted protein b3191 12 COG3113 COG3113, Predicted NTP binding protein (contains STAS domain) General function prediction only 16131823 Common thiE thiamin phosphate synthase (thiamin phosphate pyrophosphorylase) b3993 203 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 16131271 Common hofN predicted fimbrial assembly protein b3394 6 COG3166 PilN, Tfp pilus assembly protein PilN Cell motility and secretion / Intracellular trafficking and secretion 16132000 Common nsrR predicted DNA-binding transcriptional regulator b4178 159 COG1959 COG1959, Predicted transcriptional regulator Transcription 16131600 Common atpD F1 sector of membrane-bound ATP synthase, beta subunit b3732 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 16129497 Common dcp dipeptidyl carboxypeptidase II b1538 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 16129280 Common ompG outer membrane porin b1319 3 None None None 16131526 Common yicH conserved protein b3655 13 None None None 16132220 Common yjtD predicted rRNA methyltransferase b4403 153 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 16129821 Common yecE conserved protein b1868 85 COG1801 COG1801, Uncharacterized conserved protein Function unknown 16130863 Common yggX protein that protects iron-sulfur proteins against oxidative damage b2962 72 COG2924 COG2924, Uncharacterized protein conserved in bacteria Function unknown 90111598 Common yhhH predicted protein b3483 1 None None None 90111536 Common ygjP predicted metal dependent hydrolase b3085 40 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 16130220 Common nuoE NADH:ubiquinone oxidoreductase, chain E b2285 157 COG1905 NuoE, NADH:ubiquinone oxidoreductase 24 kD subunit Energy production and conversion 16130041 Common thiD bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase b2103 219 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 16128337 Common mhpE 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase, class I b0352 193 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 16128413 Common cyoE protoheme IX farnesyltransferase b0428 172 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 16130636 Common hypD protein required for maturation of hydrogenases b2729 109 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 16128912 Common pyrD dihydro-orotate oxidase, FMN-linked b0945 226 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 16131055 Common nlpI conserved protein b3163 66 COG4785 NlpI, Lipoprotein NlpI, contains TPR repeats General function prediction only 16131650 Common rffM UDP-N-acetyl-D-mannosaminuronic acid transferase b3794 109 COG1922 WecG, Teichoic acid biosynthesis proteins Cell envelope biogenesis, outer membrane 90111370 Common yeeF predicted amino-acid transporter b2014 161 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 162135899 Common hlyE hemolysin E b1182 2 None None None 16130301 Common evgA DNA-binding response regulator in two-component regulatory system with EvgS b2369 142 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 90111127 Common yaiI conserved protein b0387 96 COG1671 COG1671, Uncharacterized protein conserved in bacteria Function unknown 16129035 Common flgA assembly protein for flagellar basal-body periplasmic P ring b1072 29 COG1261 FlgA, Flagellar basal body P-ring biosynthesis protein Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 16128785 Common mntR DNA-binding transcriptional regulator of mntH b0817 91 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 16130903 Common exbD membrane spanning protein in TonB-ExbB-ExbD complex b3005 138 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 90111654 Common yigZ predicted elongation factor b3848 130 COG1739 COG1739, Uncharacterized conserved protein Function unknown 16130901 Common yghA predicted glutathionylspermidine synthase, with NAD(P)-binding Rossmann-fold domain b3003 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 94541120 Common torI response regulator inhibitor for tor operon b4501 1 COG3311 AlpA, Predicted transcriptional regulator Transcription 16131371 Common yhiR predicted DNA (exogenous) processing protein b3499 84 COG2961 ComJ, Protein involved in catabolism of external DNA General function prediction only 16131118 Common sspB ClpXP protease specificity-enhancing factor b3228 64 COG2969 SspB, Stringent starvation protein B General function prediction only 16130275 Common fadI beta-ketoacyl-CoA thiolase, anaerobic, subunit b2342 180 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 16129246 Common gmr modulator of Rnase II stability b1285 181 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 16130710 Common fucK L-fuculokinase b2803 182 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 16130955 Common ygiH conserved inner membrane protein b3059 168 COG0344 COG0344, Predicted membrane protein Function unknown 145698338 Common fabR DNA-binding transcriptional repressor b3963 42 COG1309 AcrR, Transcriptional regulator Transcription 16131568 Common recF gap repair protein b3700 166 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 16129985 Common wcaK predicted pyruvyl transferase b2045 25 COG2327 WcaK, Uncharacterized conserved protein Function unknown 16129224 Common trpD fused glutamine amidotransferase (component II) of anthranilate synthase/anthranilate phosphoribosyl transferase b1263 230 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 16129852 Common ftnB predicted ferritin-like protein b1902 73 COG1528 Ftn, Ferritin-like protein Inorganic ion transport and metabolism 16130089 Common galS DNA-binding transcriptional repressor b2151 128 COG1609 PurR, Transcriptional regulators Transcription 16131863 Common malM maltose regulon periplasmic protein b4037 17 None None None 16131858 Common malG maltose transporter subunit b4032 182 COG3833 MalG, ABC-type maltose transport systems, permease component Carbohydrate transport and metabolism 145698307 Common yqgB predicted protein b2939 3 None None None 94541134 Common yjjZ predicted protein b4567 9 None None None 90111375 Common cld regulator of length of O-antigen component of lipopolysaccharide chains b2027 15 COG3765 WzzB, Chain length determinant protein Cell envelope biogenesis, outer membrane 16130348 Common cysA sulfate/thiosulfate transporter subunit b2422 249 COG1118 CysA, ABC-type sulfate/molybdate transport systems, ATPase component Inorganic ion transport and metabolism 16128352 Common tauC taurine transporter subunit b0367 209 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 16130930 Common nudF ADP-ribose pyrophosphatase b3034 106 COG2816 NPY1, NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding DNA replication, recombination, and repair 16130946 Common yqiJ predicted inner membrane protein b3050 11 None None None 16130056 Common yehI conserved protein b2118 10 None None None 16130498 Common rpoE RNA polymerase, sigma 24 (sigma E) factor b2573 175 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 145698321 Nonpathogen dinQ Damage inducible, function unknown b4613 1 None None None 16128014 Common nhaR DNA-binding transcriptional activator b0020 108 COG0583 LysR, Transcriptional regulator Transcription 16129797 Common exoX DNA exonuclease X b1844 160 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 16130360 Common amiA N-acetylmuramoyl-l-alanine amidase I b2435 179 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 16129146 Common umuD DNA polymerase V, subunit D b1183 55 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 16128077 Common ftsI transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) b0084 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 16129683 Common ydjN predicted transporter b1729 154 COG1823 COG1823, Predicted Na+/dicarboxylate symporter General function prediction only 49176475 Common ytfR predicted sugar transporter subunit: ATP-binding component of ABC superfamily b4485 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 49176489 Common yjiC predicted protein b4325 2 None None None 16129206 Common oppC oligopeptide transporter subunit b1245 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 16129188 Common narH nitrate reductase 1, beta (Fe-S) subunit b1225 148 COG1140 NarY, Nitrate reductase beta subunit Energy production and conversion 16129767 Common nudL predicted NUDIX hydrolase b1813 112 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 90111522 Common speC ornithine decarboxylase, constitutive b2965 84 COG1982 LdcC, Arginine/lysine/ornithine decarboxylases Amino acid transport and metabolism 16128896 Common ompF outer membrane porin 1a (Ia;b;F) b0929 40 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 16129044 Common flgJ muramidase b1081 73 COG3951 COG3951, Rod binding protein Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 90111706 Common ytfH predicted transcriptional regulator b4212 141 COG1733 COG1733, Predicted transcriptional regulators Transcription 90111677 Common ubiC chorismate pyruvate lyase b4039 18 COG3161 UbiC, 4-hydroxybenzoate synthetase (chorismate lyase) Coenzyme metabolism 16129818 Common nudB dATP pyrophosphohydrolase b1865 37 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 16130652 Common truD pseudoruidine synthase b2745 86 COG0585 COG0585, Uncharacterized conserved protein Function unknown 16129467 Common hipB DNA-binding transcriptional regulator b1508 16 COG1476 COG1476, Predicted transcriptional regulators Transcription 49176077 Common hinT purine nucleoside phosphoramidase b1103 224 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 90111355 Common dcyD D-cysteine desulfhydrase, PLP-dependent b1919 69 COG2515 Acd, 1-aminocyclopropane-1-carboxylate deaminase Amino acid transport and metabolism 157783149 Common cynR DNA-binding transcriptional dual regulator b0338 191 COG0583 LysR, Transcriptional regulator Transcription 16130457 Common trmJ predicted methyltransferase b2532 157 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 16128867 Common ycaN predicted DNA-binding transcriptional regulator b0900 183 COG0583 LysR, Transcriptional regulator Transcription 145698326 Common yibV hypothetical protein, no homologs b4615 1 None None None 16130770 Common xdhC xanthine dehydrogenase, Fe-S binding subunit b2868 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 16130432 Common guaA GMP synthetase (glutamine aminotransferase) b2507 239 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 16131605 Common atpE F0 sector of membrane-bound ATP synthase, subunit c b3737 50 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 90111134 Common yajG predicted lipoprotein b0434 19 COG3056 COG3056, Uncharacterized lipoprotein Cell envelope biogenesis, outer membrane 16131955 Common lysU lysine tRNA synthetase, inducible b4129 249 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 16128683 Common phr deoxyribodipyrimidine photolyase, FAD-binding b0708 133 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 16129182 Common ychN conserved protein b1219 27 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 16129835 Common cheB fused chemotaxis regulator: protein-glutamate methylesterase in two-component regulatory system with CheA b1883 211 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 94541129 Common yidD predicted protein b4557 182 COG0759 COG0759, Uncharacterized conserved protein Function unknown 90111246 Common pspF DNA-binding transcriptional activator b1303 171 COG1221 PspF, Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain Transcription / Signal transduction mechanisms 16128698 Common sdhA succinate dehydrogenase, flavoprotein subunit b0723 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 90111391 Common yehR conserved protein b2123 8 COG4808 COG4808, Uncharacterized protein conserved in bacteria Function unknown 90111666 Common yiiM conserved protein b3910 74 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 16129391 Common ydcM predicted transposase b1432 77 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 16128224 Common gpt guanine-hypoxanthine phosphoribosyltransferase b0238 65 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 145698293 Common yfdP CPS-53 (KpLE1) prophage; predicted protein b2359 6 None None None 90111587 Common greB transcription elongation factor b3406 201 COG0782 GreA, Transcription elongation factor Transcription 16129971 Common insH IS5 transposase and trans-activator b2030 37 COG3039 COG3039, Transposase and inactivated derivatives, IS5 family DNA replication, recombination, and repair 16129231 Common btuR cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase b1270 138 COG2109 BtuR, ATP:corrinoid adenosyltransferase Coenzyme metabolism 16130501 Common srmB ATP-dependent RNA helicase b2576 238 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 16128279 Common matA predicted regulator b0294 5 COG2771 CsgD, DNA-binding HTH domain-containing proteins Transcription 16128598 Common citF citrate lyase, citrate-ACP transferase (alpha) subunit b0615 31 COG3051 CitF, Citrate lyase, alpha subunit Energy production and conversion 16129078 Common ycfT predicted inner membrane protein b1115 16 COG4763 COG4763, Predicted membrane protein Function unknown 90111426 Common lpxP palmitoleoyl-acyl carrier protein (ACP)-dependent acyltransferase b2378 96 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 16129801 Common yebG conserved protein regulated by LexA b1848 17 COG3141 COG3141, Uncharacterized protein conserved in bacteria Function unknown 16130842 Common yqgD predicted inner membrane protein b2941 3 None None None 16132139 Common fimF minor component of type 1 fimbriae b4318 21 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16130891 Common hybF protein involved with the maturation of hydrogenases 1 and 2 b2991 95 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 16128758 Common ybhP predicted DNase b0790 67 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 16129460 Common ydeP predicted oxidoreductase b1501 173 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 90111747 Common slt lytic murein transglycosylase, soluble b4392 171 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 90111580 Common yhfY conserved protein b3382 10 None None None 90111194 Common yccS predicted inner membrane protein b0960 59 COG1289 COG1289, Predicted membrane protein Function unknown 16129267 Common pspC DNA-binding transcriptional activator b1306 28 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 90111406 Common yfaV predicted transporter b2246 114 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 16130012 Common yegK predicted protein b2072 11 None None None 16129874 Common amyA cytoplasmic alpha-amylase b1927 47 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 16130058 Common yehM predicted protein b2120 22 None None None 16129160 Common treA periplasmic trehalase b1197 27 COG1626 TreA, Neutral trehalase Carbohydrate transport and metabolism 16130948 Common rfaE fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase b3052 180 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 90111285 Common ydeM conserved protein b1497 118 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 90111184 Common ycaM predicted transporter b0899 72 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 16131539 Common uhpA DNA-binding response regulator in two-component regulatory system wtih UhpB b3669 185 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 16128595 Common citT citrate:succinate antiporter b0612 106 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 16128624 Common rlpB minor lipoprotein b0641 28 COG2980 RlpB, Rare lipoprotein B Cell envelope biogenesis, outer membrane 16128284 Common insF IS3 element protein InsF b0299 149 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 16132149 Common iadA isoaspartyl dipeptidase b4328 44 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 90111295 Common essQ Qin prophage; predicted S lysis protein b1556 5 None None None 16129152 Common dadA D-amino acid dehydrogenase b1189 119 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 16131621 Common rbsR DNA-binding transcriptional repressor of ribose metabolism b3753 129 COG1609 PurR, Transcriptional regulators Transcription 16129517 Common cspF Qin prophage; cold shock protein b1558 41 COG1278 CspC, Cold shock proteins Transcription 16132177 Common yjjL predicted transporter b4356 206 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 16129272 Common ycjO predicted sugar transporter subunit: membrane component of ABC superfamily b1311 151 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 16130882 Common insH IS5 transposase and trans-activator b2982 37 COG3039 COG3039, Transposase and inactivated derivatives, IS5 family DNA replication, recombination, and repair 16131236 Common crp DNA-binding transcriptional dual regulator b3357 167 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 16129398 Common ydcR fused predicted DNA-binding transcriptional regulator/predicted amino transferase b1439 231 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 16132068 Common pyrL pyrBI operon leader peptide b4246 4 None None None 16131881 Common aphA acid phosphatase/phosphotransferase, class B, non-specific b4055 12 COG3700 AphA, Acid phosphatase (class B) General function prediction only 90111163 Common abrB predicted regulator b0715 56 COG3180 AbrB, Putative ammonia monooxygenase General function prediction only 16130433 Common guaB IMP dehydrogenase b2508 238 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 16128083 Common murG N-acetylglucosaminyl transferase b0090 208 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 16128061 Common thiP fused thiamin transporter subunits of ABC superfamily: membrane components b0067 178 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 16128534 Common ybcQ DLP12 prophage; predicted antitermination protein b0551 6 None None None 16131944 Common melR DNA-binding transcriptional dual regulator b4118 112 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16130742 Common lysA diaminopimelate decarboxylase, PLP-binding b2838 218 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 16128068 Common leuA 2-isopropylmalate synthase b0074 216 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 16129478 Common tam trans-aconitate methyltransferase b1519 87 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 16131155 Common yhdV predicted outer membrane protein b3267 7 None None None 49176353 Common glpG predicted intramembrane serine protease b3424 102 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 16128583 Common ybdL methionine aminotransferase, PLP-dependent b0600 239 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 90111742 Common yjjA conserved protein b4360 14 None None None 16130234 Common yfcD predicted NUDIX hydrolase b2299 24 COG1443 Idi, Isopentenyldiphosphate isomerase Lipid metabolism 16129445 Common ddpB D-ala-D-ala transporter subunit b1486 218 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 16132085 Common yjgR predicted ATPase b4263 79 COG0433 COG0433, Predicted ATPase General function prediction only 16131972 Common efp Elongation factor EF-P b4147 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 16128386 Common brnQ predicted branched chain amino acid transporter (LIV-II) b0401 50 COG1114 BrnQ, Branched-chain amino acid permeases Amino acid transport and metabolism 90111289 Common marR DNA-binding transcriptional repressor of multiple antibiotic resistance b1530 92 COG1846 MarR, Transcriptional regulators Transcription 16128825 Common potI putrescine transporter subunit: membrane component of ABC superfamily b0857 173 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 16132043 Common ytfN conserved protein b4221 93 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 16131515 Common yicC conserved protein b3644 137 COG1561 COG1561, Uncharacterized stress-induced protein Function unknown 16128586 Common ybdO predicted DNA-binding transcriptional regulator b0603 114 COG0583 LysR, Transcriptional regulator Transcription 16128346 Common insD KpLE2 phage-like element; IS2 insertion element transposase InsAB' b0361 92 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 16128832 Common artP arginine transporter subunit b0864 249 COG4161 ArtP, ABC-type arginine transport system, ATPase component Amino acid transport and metabolism 16128267 Common yagP predicted transcriptional regulator b0282 51 COG0583 LysR, Transcriptional regulator Transcription 16131868 Common dgkA diacylglycerol kinase b4042 92 COG0818 DgkA, Diacylglycerol kinase Cell envelope biogenesis, outer membrane 90111519 Common yggL predicted protein b2959 25 COG3171 COG3171, Uncharacterized protein conserved in bacteria Function unknown 16129005 Common csgA cryptic curlin major subunit b1042 12 None None None 90111575 Common nirC nitrite transporter b3367 90 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 90111462 Common yfiE predicted DNA-binding transcriptional regulator b2577 186 COG0583 LysR, Transcriptional regulator Transcription 16131177 Common rpsM 30S ribosomal subunit protein S13 b3298 245 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 16128054 Common polB DNA polymerase II b0060 64 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 16129527 Common ydfX Qin prophage; predicted protein b1568 2 None None None 16130605 Common recX regulatory protein for RecA b2698 69 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 16131698 Common mobA molybdopterin-guanine dinucleotide synthase b3857 136 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 16130803 Common bglA 6-phospho-beta-glucosidase A b2901 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 16128723 Common gpmA phosphoglyceromutase 1 b0755 162 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 16130962 Common dnaG DNA primase b3066 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 16131452 Common sgbH 3-keto-L-gulonate 6-phosphate decarboxylase b3581 54 COG0269 SgbH, 3-hexulose-6-phosphate synthase and related proteins Carbohydrate transport and metabolism 145698339 Common yjbT hypothetical protein, no homologs b4620 2 None None None 16129929 Common cbl DNA-binding transcriptional activator of cysteine biosynthesis b1987 191 COG0583 LysR, Transcriptional regulator Transcription 16128401 Common nusB transcription antitermination protein b0416 196 COG0781 NusB, Transcription termination factor Transcription 16128430 Common ybaE predicted transporter subunit: periplasmic-binding component of ABC superfamily b0445 38 COG4533 COG4533, ABC-type uncharacterized transport system, periplasmic component General function prediction only 16131263 Common gph phosphoglycolate phosphatase b3385 215 COG0546 Gph, Predicted phosphatases General function prediction only 16129570 Common fumA fumarate hydratase (fumarase A), aerobic Class I b1612 147 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 16128951 Common gfcC conserved protein b0985 15 None None None 16131595 Common pstC phosphate transporter subunit b3727 225 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 16128902 Common ssuD alkanesulfonate monooxygenase, FMNH(2)-dependent b0935 84 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 16131299 Common glpE thiosulfate:cyanide sulfurtransferase (rhodanese) b3425 98 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 16130829 Common yggC conserved protein with nucleoside triphosphate hydrolase domain b2928 58 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 16131207 Common gspG pseudopilin, cryptic, general secretion pathway b3328 106 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 16129697 Common spy envelope stress induced periplasmic protein b1743 19 COG3678 CpxP, P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism 16129993 Common gmd GDP-D-mannose dehydratase, NAD(P)-binding b2053 228 COG1089 Gmd, GDP-D-mannose dehydratase Cell envelope biogenesis, outer membrane 49176257 Common ygaM predicted protein b2672 16 COG4575 ElaB, Uncharacterized conserved protein Function unknown 16130242 Common hisM histidine/lysine/arginine/ornithine transporter subunit b2307 172 COG4160 ArtM, ABC-type arginine/histidine transport system, permease component Amino acid transport and metabolism 16128203 Common yafT predicted aminopeptidase b0217 3 None None None 16128447 Common acrA multidrug efflux system b0463 147 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 16130929 Common yqiB predicted dehydrogenase b3033 26 COG3151 COG3151, Uncharacterized protein conserved in bacteria Function unknown 16130541 Nonpathogen yfjH CP4-57 prophage; predicted protein b2623 1 None None None 16130175 Common glpT sn-glycerol-3-phosphate transporter b2240 85 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 16129917 Common yedY predicted reductase b1971 125 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 16128529 Common ybcM DLP12 prophage; predicted DNA-binding transcriptional regulator b0546 53 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16129891 Common fliL flagellar biosynthesis protein b1944 35 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 16129901 Common yedP conserved protein b1955 30 COG3769 COG3769, Predicted hydrolase (HAD superfamily) General function prediction only 16130392 Common nudK predicted NUDIX hydrolase b2467 155 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 16129217 Common ompW outer membrane protein W b1256 71 COG3047 OmpW, Outer membrane protein W Cell envelope biogenesis, outer membrane 16128636 Common gltK glutamate and aspartate transporter subunit b0653 175 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 16128558 Common cusA copper/silver efflux system, membrane component b0575 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 16128197 Common yafE predicted S-adenosyl-L-methionine-dependent methyltransferase b0210 165 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 16128909 Common ycbU predicted fimbrial-like adhesin protein b0942 8 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16131195 Common rpsS 30S ribosomal subunit protein S19 b3316 245 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 16130587 Common nrdH glutaredoxin-like protein b2673 36 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 16131689 Common ubiD 3-octaprenyl-4-hydroxybenzoate decarboxylase b3843 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 16128160 Common glnD uridylyltransferase b0167 123 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 16128392 Common yajC SecYEG protein translocase auxillary subunit b0407 168 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 16128425 Common hupB HU, DNA-binding transcriptional regulator, beta subunit b0440 200 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 16132182 Common dnaC DNA biosynthesis protein b4361 41 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 16128819 Common nfsA nitroreductase A, NADPH-dependent, FMN-dependent b0851 82 COG0778 NfnB, Nitroreductase Energy production and conversion 16129059 Common pabC 4-amino-4-deoxychorismate lyase component of para-aminobenzoate synthase multienzyme complex b1096 163 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 16131967 Common groS Cpn10 chaperonin GroES, small subunit of GroESL b4142 216 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 16129610 Common rnt ribonuclease T (RNase T) b1652 59 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 16130214 Common nuoK NADH:ubiquinone oxidoreductase, membrane subunit K b2279 67 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 90111337 Common yoaD predicted phosphodiesterase b1815 163 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 16129017 Common lpxL lauryl-acyl carrier protein (ACP)-dependent acyltransferase b1054 102 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 16129999 Common wcaA predicted glycosyl transferase b2059 156 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 16129099 Common icd e14 prophage; isocitrate dehydrogenase, specific for NADP+ b1136 222 COG0538 Icd, Isocitrate dehydrogenases Energy production and conversion 16131920 Common phnN ribose 1,5-bisphosphokinase b4094 71 COG3709 COG3709, Uncharacterized component of phosphonate metabolism Inorganic ion transport and metabolism 16130322 Common ypeC conserved protein b2390 9 None None None 16130779 Common ygfJ conserved protein b2877 54 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 16129976 Common glf UDP-galactopyranose mutase, FAD/NAD(P)-binding b2036 54 COG0562 Glf, UDP-galactopyranose mutase Cell envelope biogenesis, outer membrane 16130706 Common fucO L-1,2-propanediol oxidoreductase b2799 174 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 90111110 Common ykgB conserved inner membrane protein b0301 24 COG3059 COG3059, Predicted membrane protein Function unknown 16132200 Common deoB phosphopentomutase b4383 70 COG1015 DeoB, Phosphopentomutase Carbohydrate transport and metabolism 16130998 Common yhaH predicted inner membrane protein b3103 69 COG3152 COG3152, Predicted membrane protein Function unknown 16132130 Common yjhS conserved protein b4309 2 None None None 145698243 Common ymgI hypothetical protein b4593 1 None None None 16129293 Common ynaJ predicted inner membrane protein b1332 6 None None None 49175994 Common setA broad specificity sugar efflux system b0070 84 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 90111659 Common yihV predicted sugar kinase b3883 96 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 16130496 Common rseB anti-sigma factor b2571 48 COG3026 RseB, Negative regulator of sigma E activity Signal transduction mechanisms 16128513 Common folD bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase b0529 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 16130695 Common gudX predicted glucarate dehydratase b2788 50 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 145698341 Common yjbS hypothetical protein b4621 2 None None None 49176171 Common yedK predicted protein b1931 96 COG2135 COG2135, Uncharacterized conserved protein Function unknown 16131772 Common cytR DNA-binding transcriptional dual regulator b3934 127 COG1609 PurR, Transcriptional regulators Transcription 16130725 Common ptrA protease III b2821 183 COG1025 Ptr, Secreted/periplasmic Zn-dependent peptidases, insulinase-like Posttranslational modification, protein turnover, chaperones 16129298 Common abgB predicted peptidase, aminobenzoyl-glutamate utilization protein b1337 89 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 16129567 Common rstB sensory histidine kinase in two-component regulatory system with RstA b1609 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 16131032 Common agaD N-acetylgalactosamine-specific enzyme IID component of PTS b3140 41 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 16131018 Common garL alpha-dehydro-beta-deoxy-D-glucarate aldolase b3126 74 COG3836 HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase Carbohydrate transport and metabolism 16128711 Common ybgC predicted acyl-CoA thioesterase b0736 134 COG0824 FcbC, Predicted thioesterase General function prediction only 49176140 Common katE hydroperoxidase HPII(III) (catalase) b1732 126 COG0753 KatE, Catalase Inorganic ion transport and metabolism 16128190 Common metQ DL-methionine transporter subunit b0197 101 COG1464 NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen Inorganic ion transport and metabolism 16128706 Common mngA fused 2-O-a-mannosyl-D-glycerate specific PTS enzymes: IIA component/IIB component/IIC component b0731 99 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 16129776 Common rrmA 23S rRNA m1G745 methyltransferase b1822 101 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 49176293 Common yghJ predicted inner membrane lipoprotein b4466 3 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 16128489 Common allA ureidoglycolate hydrolase b0505 35 COG3194 DAL3, Ureidoglycolate hydrolase Nucleotide transport and metabolism 145698287 Common ypaA predicted protein b4543 8 COG5464 COG5464, Uncharacterized conserved protein Function unknown 90111591 Common gntK gluconate kinase 2 b3437 80 COG3265 GntK, Gluconate kinase Carbohydrate transport and metabolism 16128292 Common ykgF predicted amino acid dehydrogenase with NAD(P)-binding domain and ferridoxin-like domain b0307 95 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 16130385 Common eutQ conserved protein b2460 19 COG4766 EutQ, Ethanolamine utilization protein Amino acid transport and metabolism 16130876 Common glcB malate synthase G b2976 72 COG2225 AceB, Malate synthase Energy production and conversion 16129473 Common lsrC AI2 transporter b1514 115 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 16131011 Common tdcA DNA-binding transcriptional activator b3118 187 COG0583 LysR, Transcriptional regulator Transcription 16129577 Common hdhA 7-alpha-hydroxysteroid dehydrogenase, NAD-dependent b1619 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 16130533 Common grpE heat shock protein b2614 231 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 16128021 Common lspA prolipoprotein signal peptidase (signal peptidase II) b0027 196 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 16128501 Common allD ureidoglycolate dehydrogenase b0517 67 COG2055 COG2055, Malate/L-lactate dehydrogenases Energy production and conversion 16130414 Common hyfI hydrogenase 4, Fe-S subunit b2489 192 COG3260 COG3260, Ni,Fe-hydrogenase III small subunit Energy production and conversion 16130853 Common yggT predicted inner membrane protein b2952 74 COG0762 COG0762, Predicted integral membrane protein Function unknown 16128528 Common ybcL DLP12 prophage; predicted kinase inhibitor b0545 126 COG1881 COG1881, Phospholipid-binding protein General function prediction only 16129576 Common uidR DNA-binding transcriptional repressor b1618 120 COG1309 AcrR, Transcriptional regulator Transcription 90111342 Common yebV predicted protein b1836 10 None None None 16128311 Common yahL predicted protein b0326 2 None None None 16128732 Common modB molybdate transporter subunit b0764 226 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 16130029 Common gatD galactitol-1-phosphate dehydrogenase, Zn-dependent and NAD(P)-binding b2091 200 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 90111430 Common cysW sulfate/thiosulfate transporter subunit b2423 224 COG4208 CysW, ABC-type sulfate transport system, permease component Inorganic ion transport and metabolism 16130030 Common gatC galactitol-specific enzyme IIC component of PTS b2092 19 COG3775 GatC, Phosphotransferase system, galactitol-specific IIC component Carbohydrate transport and metabolism 16128570 Common fepE regulator of length of O-antigen component of lipopolysaccharide chains b0587 19 COG3765 WzzB, Chain length determinant protein Cell envelope biogenesis, outer membrane 16128439 Common ybaZ predicted methyltransferase b0454 153 COG3695 COG3695, Predicted methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 49176090 Common oppD oligopeptide transporter subunit b1246 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 90111546 Common agaV N-acetylgalactosamine-specific enzyme IIB component of PTS b3133 41 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 16131746 Common rhaR DNA-binding transcriptional activator, L-rhamnose-binding b3906 116 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16130624 Common hycI protease involved in processing C-terminal end of HycE b2717 37 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 16130427 Common ppx exopolyphosphatase b2502 180 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 16128606 Common cspE DNA-binding transcriptional repressor b0623 180 COG1278 CspC, Cold shock proteins Transcription 94541131 Common yjdO predicted protein b4559 9 None None None 16131666 Common corA magnesium/nickel/cobalt transporter b3816 148 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 16128576 Common entC isochorismate synthase 1 b0593 223 COG1169 MenF, Isochorismate synthase Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism 16129428 Common narU nitrate/nitrite transporter b1469 79 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 16132117 Common yjhF KpLE2 phage-like element; predicted transporter b4296 76 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 16128318 Common prpC 2-methylcitrate synthase b0333 194 COG0372 GltA, Citrate synthase Energy production and conversion 16131216 Common bfd bacterioferritin-associated ferredoxin b3337 24 COG2906 Bfd, Bacterioferritin-associated ferredoxin Inorganic ion transport and metabolism 16129706 Common ydjZ conserved inner membrane protein b1752 113 COG0398 COG0398, Uncharacterized conserved protein Function unknown 16130617 Common norV flavorubredoxin oxidoreductase b2710 127 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 16130791 Common idi isopentenyl diphosphate isomerase b2889 52 COG1443 Idi, Isopentenyldiphosphate isomerase Lipid metabolism 16131000 Common yhaJ predicted DNA-binding transcriptional regulator b3105 153 COG0583 LysR, Transcriptional regulator Transcription 49176127 Common blr beta-lactam resistance membrane protein b4409 3 None None None 16130130 Common narP DNA-binding response regulator in two-component regulatory system with NarQ or NarX b2193 219 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 16128621 Common cobC predicted alpha-ribazole-5'-P phosphatase b0638 176 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 94541112 Common ynfO hypothetical protein, Qin prophage b4533 2 None None None 16130289 Common yfdN CPS-53 (KpLE1) prophage; predicted protein b2357 2 None None None 16131285 Common feoB fused ferrous iron transporter, protein B: GTP-binding protein/membrane protein b3409 179 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 16130988 Common exuT hexuronate transporter b3093 112 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 16129560 Common pntB pyridine nucleotide transhydrogenase, beta subunit b1602 123 COG1282 PntB, NAD/NADP transhydrogenase beta subunit Energy production and conversion 16130339 Common cysZ predicted inner membrane protein b2413 48 COG2981 CysZ, Uncharacterized protein involved in cysteine biosynthesis Amino acid transport and metabolism 16128261 Common yagJ CP4-6 prophage; predicted protein b0276 8 None None None 90111474 Common ypjA adhesin-like autotransporter b2647 100 COG3468 AidA, Type V secretory pathway, adhesin AidA Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 16128949 Common gfcE predicted exopolysaccharide export protein b0983 125 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 16131766 Common yiiU conserved protein b3928 21 COG3074 COG3074, Uncharacterized protein conserved in bacteria Function unknown 16131292 Common malQ 4-alpha-glucanotransferase (amylomaltase) b3416 119 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 16131137 Common mreD cell wall structural complex MreBCD transmembrane component MreD b3249 50 COG2891 MreD, Cell shape-determining protein Cell envelope biogenesis, outer membrane 16129886 Common fliG flagellar motor switching and energizing component b1939 123 COG1536 FliG, Flagellar motor switch protein Cell motility and secretion 16128662 Common ybfF conserved protein b0686 134 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 16131589 Common bglB cryptic phospho-beta-glucosidase B b3721 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 16129167 Common pth peptidyl-tRNA hydrolase b1204 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 16131340 Common yhhN conserved inner membrane protein b3468 15 COG3714 COG3714, Predicted membrane protein Function unknown 90111458 Common yfhK predicted sensory kinase in two-component system b2556 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 16128985 Common pgaD predicted inner membrane protein b1021 2 None None None 16130124 Common yejK nucleotide associated protein b2186 31 COG3081 COG3081, Nucleoid-associated protein General function prediction only 16130649 Common nlpD predicted outer membrane lipoprotein b2742 190 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 16130317 Common ypdF predicted peptidase b2385 248 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 16130456 Common iscR DNA-binding transcriptional repressor b2531 162 COG1959 COG1959, Predicted transcriptional regulator Transcription 16128463 Common fsr predicted fosmidomycin efflux system b0479 66 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 16128765 Common rhlE RNA helicase b0797 236 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 16130601 Common yqaA conserved inner membrane protein b2689 73 COG1238 COG1238, Predicted membrane protein Function unknown 90111465 Common yfiL predicted protein b2602 6 None None None 16131198 Common rplD 50S ribosomal subunit protein L4 b3319 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 16129341 Common ldhA fermentative D-lactate dehydrogenase, NAD-dependent b1380 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 16130733 Common ptsP fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein b2829 235 COG3605 PtsP, Signal transduction protein containing GAF and PtsI domains Signal transduction mechanisms 49176434 Common typA GTP-binding protein b3871 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 16128931 Common yccT conserved protein b0964 19 COG3110 COG3110, Uncharacterized protein conserved in bacteria Function unknown 16130252 Common dedA conserved inner membrane protein b2317 172 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 16128253 Common yagE CP4-6 prophage; predicted lyase/synthase b0268 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 16128491 Common gcl glyoxylate carboligase b0507 221 COG3960 COG3960, Glyoxylate carboligase General function prediction only 90111096 Common yaeR predicted lyase b0187 41 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 16130198 Common yfbB predicted peptidase b2263 72 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 16129407 Common yncA predicted acyltransferase with acyl-CoA N-acyltransferase domain b1448 110 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 16132216 Common creC sensory histidine kinase in two-component regulatory system with CreB or PhoB, regulator of the CreBC regulon b4399 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 16131171 Common zntR DNA-binding transcriptional activator in response to Zn(II) b3292 155 COG0789 SoxR, Predicted transcriptional regulators Transcription 16131463 Common yibF predicted glutathione S-transferase b3592 80 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 16129983 Common wcaM predicted colanic acid biosynthesis protein b2043 5 None None None 16131143 Common accB acetyl CoA carboxylase, BCCP subunit b3255 197 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 90111236 Common yciU predicted protein b1248 18 COG3099 COG3099, Uncharacterized protein conserved in bacteria Function unknown 16131573 Common yidC cytoplasmic insertase into membrane protein, Sec system b3705 214 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 16131710 Common glnA glutamine synthetase b3870 227 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 16132122 Common sgcE KpLE2 phage-like element; predicted epimerase b4301 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 90111324 Common ynjE predicted thiosulfate sulfur transferase b1757 144 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 16128669 Common speF ornithine decarboxylase isozyme, inducible b0693 82 COG1982 LdcC, Arginine/lysine/ornithine decarboxylases Amino acid transport and metabolism 16130154 Common rcsB DNA-binding response regulator in two-component regulatory system with RcsC and YojN b2217 170 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 16128844 Common ybjD conserved protein with nucleoside triphosphate hydrolase domain b0876 32 COG3593 COG3593, Predicted ATP-dependent endonuclease of the OLD family DNA replication, recombination, and repair 16128674 Common kdpA potassium translocating ATPase, subunit A b0698 96 COG2060 KdpA, K+-transporting ATPase, A chain Inorganic ion transport and metabolism 16128926 Common sxy conserved protein b0959 20 COG3070 TfoX, Regulator of competence-specific genes Transcription 16129193 Common purU formyltetrahydrofolate hydrolase b1232 219 COG0788 PurU, Formyltetrahydrofolate hydrolase Nucleotide transport and metabolism 90111325 Common ynjF predicted phosphatidyl transferase, inner membrane protein b1758 46 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 16130102 Common yeiM predicted nucleoside transporter b2164 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 16128888 Common smtA predicted S-adenosyl-L-methionine-dependent methyltransferase b0921 94 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 16128659 Common fur DNA-binding transcriptional dual regulator of siderophore biosynthesis and transport b0683 196 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 90111446 Common hyfJ predicted processing element hydrogenase 4 b2490 13 None None None 145698267 Nonpathogen ydgU hypothetical protein b4601 1 None None None 90111084 Common ilvI acetolactate synthase III, large subunit b0077 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 16130377 Common eutH predicted inner membrane protein b2452 18 COG3192 EutH, Ethanolamine utilization protein Amino acid transport and metabolism 16129751 Common yeaR conserved protein b1797 16 COG3615 TehB, Uncharacterized protein/domain, possibly involved in tellurite resistance Inorganic ion transport and metabolism 16131325 Common ugpB glycerol-3-phosphate transporter subunit b3453 106 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 16130683 Common ygcE predicted kinase b2776 173 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 16130921 Common qseB DNA-binding response regulator in two-component regulatory system with QseC b3025 219 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 16129717 Common topB DNA topoisomerase III b1763 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 16130890 Common hybG hydrogenase 2 accessory protein b2990 72 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 16130244 Common hisJ histidine/lysine/arginine/ornithine transporter subunit b2309 175 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 16128327 Common lacA thiogalactoside acetyltransferase b0342 215 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 16128421 Common tig peptidyl-prolyl cis/trans isomerase (trigger factor) b0436 217 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 90111206 Common ycdZ predicted inner membrane protein b1036 16 None None None 16130268 Common yfcP predicted fimbrial-like adhesin protein b2333 13 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 90111346 Common znuA zinc transporter subunit: periplasmic-binding component of ABC superfamily b1857 164 COG4531 ZnuA, ABC-type Zn2+ transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 16129435 Common fdnI formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible b1476 61 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 16130528 Common trmD tRNA (guanine-1-)-methyltransferase b2607 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 16130075 Common yohF predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain b2137 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 16128332 Common mhpA 3-(3-hydroxyphenyl)propionate hydroxylase b0347 109 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 145698260 Common yddG predicted methyl viologen efflux pump b1473 45 None None None 16129794 Common yobA conserved protein b1841 25 COG2372 CopC, Uncharacterized protein, homolog of Cu resistance protein CopC General function prediction only 90111303 Common clcB predicted voltage-gated chloride channel b1592 136 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 90111484 Common ygcN predicted oxidoreductase with FAD/NAD(P)-binding domain b2766 109 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 16131442 Common malS alpha-amylase b3571 155 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 90111278 Common yddH conserved protein b1462 62 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 16130080 Common yohK predicted inner membrane protein b2142 84 COG1346 LrgB, Putative effector of murein hydrolase Cell envelope biogenesis, outer membrane 16128156 Common yaeH conserved protein b0163 17 None None None 16129863 Common sdiA DNA-binding transcriptional activator b1916 84 COG2771 CsgD, DNA-binding HTH domain-containing proteins Transcription 94541094 Common ykfH predicted protein b4504 4 None None None 16130620 Common hydN formate dehydrogenase-H, [4Fe-4S] ferredoxin subunit b2713 149 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 16131928 Common phnF predicted DNA-binding transcriptional regulator of phosphonate uptake and biodegradation b4102 112 COG2188 PhnF, Transcriptional regulators Transcription 16130639 Common ygbA predicted protein b2732 19 None None None 90111352 Common yecM predicted metal-binding enzyme b1875 20 COG3102 COG3102, Uncharacterized protein conserved in bacteria Function unknown 16129859 Common pgsA phosphatidylglycerophosphate synthetase b1912 203 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 16128790 Common ybiV predicted hydrolase b0822 120 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 90111664 Common frvB fused predicted PTS enzymes: IIB component/IIC component b3899 68 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 16128030 Common caiD crotonobetainyl CoA hydratase b0036 179 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 16130657 Common cysC adenosine 5'-phosphosulfate kinase b2750 145 COG0529 CysC, Adenylylsulfate kinase and related kinases Inorganic ion transport and metabolism 145698265 Nonpathogen ydfW Qin prophage; predicted protein b1567 1 None None None 16131472 Common mtlR DNA-binding repressor b3601 18 COG3722 MtlR, Transcriptional regulator Transcription 90111712 Common yjgJ predicted transcriptional regulator b4251 80 COG1309 AcrR, Transcriptional regulator Transcription 16129778 Common yobF predicted protein b1824 4 None None None 16129073 Common ycfJ predicted protein b1110 49 COG3134 COG3134, Predicted outer membrane lipoprotein Function unknown 90111564 Common mreB cell wall structural complex MreBCD, actin-like component MreB b3251 235 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 16128561 Common nfsB dihydropteridine reductase, NAD(P)H-dependent, oxygen-insensitive b0578 62 COG0778 NfnB, Nitroreductase Energy production and conversion 16129424 Common narV nitrate reductase 2 (NRZ), gamma subunit b1465 58 COG2181 NarI, Nitrate reductase gamma subunit Energy production and conversion 90111618 Common sgbU predicted L-xylulose 5-phosphate 3-epimerase b3582 31 COG3623 SgaU, Putative L-xylulose-5-phosphate 3-epimerase Carbohydrate transport and metabolism 16129143 Common ycgM predicted isomerase/hydrolase b1180 179 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 16129855 Common ftnA ferritin iron storage protein (cytoplasmic) b1905 84 COG1528 Ftn, Ferritin-like protein Inorganic ion transport and metabolism 16129495 Common ydeI conserved protein b1536 15 COG3111 COG3111, Uncharacterized conserved protein Function unknown 16130400 Common ypfJ conserved protein b2475 87 COG2321 COG2321, Predicted metalloprotease General function prediction only 16131713 Common yihM predicted sugar phosphate isomerase b3873 10 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 16131431 Common glyQ glycine tRNA synthetase, alpha subunit b3560 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 16129632 Common pykF pyruvate kinase I b1676 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 16128741 Common ybhB predicted kinase inhibitor b0773 126 COG1881 COG1881, Phospholipid-binding protein General function prediction only 16130047 Common yehB predicted outer membrane protein b2109 38 COG3188 FimD, P pilus assembly protein, porin PapC Cell motility and secretion / Intracellular trafficking and secretion 16129222 Common trpB tryptophan synthase, beta subunit b1261 224 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 90111558 Common nanK predicted N-acetylmannosamine kinase b3222 101 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 145698228 Nonpathogen ylcH hypothetical protein, DLP12 prophage b4588 1 None None None 16128403 Common pgpA phosphatidylglycerophosphatase A b0418 105 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 90111625 Common slmA division inhibitor b3641 54 COG1309 AcrR, Transcriptional regulator Transcription 16131496 Common rfaY lipopolysaccharide core biosynthesis protein b3625 5 COG0661 AarF, Predicted unusual protein kinase General function prediction only 49176235 Common iscS cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent b2530 239 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 90111147 Common sfmA predicted fimbrial-like adhesin protein b0530 19 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 49176017 Common phoA bacterial alkaline phosphatase b0383 85 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 90111538 Common yqjC conserved protein b3097 17 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 16129545 Common ynfE oxidoreductase subunit b1587 185 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 16131706 Common yihI conserved protein b3866 21 COG3078 COG3078, Uncharacterized protein conserved in bacteria Function unknown 16129388 Common tehA potassium-tellurite ethidium and proflavin transporter b1429 49 COG1275 TehA, Tellurite resistance protein and related permeases Inorganic ion transport and metabolism 16130117 Common yejE predicted oligopeptide transporter subunit b2179 218 COG4239 COG4239, ABC-type uncharacterized transport system, permease component General function prediction only 16131121 Common rplM 50S ribosomal subunit protein L13 b3231 240 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 16131475 Common lldR DNA-binding transcriptional repressor b3604 132 COG2186 FadR, Transcriptional regulators Transcription 16128780 Common dps Fe-binding and storage protein b0812 118 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 145698238 Common hspQ DNA-binding protein, hemimethylated b0966 25 COG3785 COG3785, Uncharacterized conserved protein Function unknown 16130993 Common yqjD conserved protein b3098 10 COG4575 ElaB, Uncharacterized conserved protein Function unknown 16130095 Common yeiE predicted DNA-binding transcriptional regulator b2157 187 COG0583 LysR, Transcriptional regulator Transcription 16131831 Common yjaH conserved protein b4001 10 None None None 90111312 Common ydhL conserved protein b1648 26 COG3313 COG3313, Predicted Fe-S protein General function prediction only 90111129 Common yajI predicted lipoprotein b0412 8 None None None 16129211 Common kch voltage-gated potassium channel b1250 109 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 16131946 Common melB melibiose:sodium symporter b4120 78 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 16129552 Common dgsA DNA-binding transcriptional repressor b1594 166 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 16131631 Common ilvY DNA-binding transcriptional dual regulator b3773 190 COG0583 LysR, Transcriptional regulator Transcription 90111532 Common yqiH predicted periplasmic pilin chaperone b3047 24 COG3121 FimC, P pilus assembly protein, chaperone PapD Cell motility and secretion / Intracellular trafficking and secretion 16130815 Common rpiA ribose 5-phosphate isomerase, constitutive b2914 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 16131664 Common yigB predicted hydrolase b3812 65 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 16128218 Common yafN predicted antitoxin of the YafO-YafN toxin-antitoxin system b0232 11 COG2161 StbD, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 16131996 Common hflK modulator for HflB protease specific for phage lambda cII repressor b4174 214 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 90111266 Common ydbD predicted protein b1407 2 None None None 16128787 Common ybiS conserved protein b0819 87 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 16130670 Common cysI sulfite reductase, beta subunit, NAD(P)-binding, heme-binding b2763 134 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 16130712 Common fucR DNA-binding transcriptional activator b2805 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 145698336 Common yiiE predicted transcriptional regulator b3889 4 COG3905 COG3905, Predicted transcriptional regulator Transcription 16131511 Common dut deoxyuridinetriphosphatase b3640 181 COG0756 Dut, dUTPase Nucleotide transport and metabolism 16129013 Common yceK predicted lipoprotein b1050 9 COG5645 COG5645, Predicted periplasmic lipoprotein General function prediction only 16132109 Common fecD KpLE2 phage-like element; iron-dicitrate transporter subunit b4288 189 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 16131541 Common ilvB acetolactate synthase I, large subunit b3671 223 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 16130810 Common pepP proline aminopeptidase P II b2908 245 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 90111410 Common pmrD polymyxin resistance protein B b2259 4 None None None 90111182 Common macA macrolide transporter subunit, membrane fusion protein (MFP) component b0878 174 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 90111687 Common yjcZ conserved protein b4110 5 None None None 16130298 Common dsdA D-serine ammonia-lyase b2366 39 COG3048 DsdA, D-serine dehydratase Amino acid transport and metabolism 16130978 Common ygjN conserved protein b3083 24 COG4680 COG4680, Uncharacterized protein conserved in bacteria Function unknown 16128042 Common folA dihydrofolate reductase b0048 146 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 90111433 Common yfeX conserved protein b2431 50 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 157783152 Common rph defective ribonuclease PH b3643 187 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 16130148 Common yojI fused predicted multidrug transport subunits of ABC superfamily: membrane component/ATP-binding component b2211 249 COG4615 PvdE, ABC-type siderophore export system, fused ATPase and permease components Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism 145698314 Common garK glycerate kinase I b3124 81 COG1929 COG1929, Glycerate kinase Carbohydrate transport and metabolism 16130273 Common sixA phosphohistidine phosphatase b2340 51 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 16130141 Common napH ferredoxin-type protein essential for electron transfer from ubiquinol to periplasmic nitrate reductase (NapAB) b2204 59 COG0348 NapH, Polyferredoxin Energy production and conversion 16129208 Common oppF oligopeptide transporter subunit b1247 249 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 16130944 Common yqiI conserved protein b3048 5 None None None 16130159 Common atoA acetyl-CoA:acetoacetyl-CoA transferase, beta subunit b2222 98 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 16128415 Common cyoC cytochrome o ubiquinol oxidase subunit III b0430 158 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 16130599 Common luxS S-ribosylhomocysteinase b2687 55 COG1854 LuxS, LuxS protein involved in autoinducer AI2 synthesis Signal transduction mechanisms 16129029 Common rimJ ribosomal-protein-S5-alanine N-acetyltransferase b1066 99 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 16131407 Common yhjR conserved protein b3535 8 None None None 16131895 Common acs acetyl-CoA synthetase b4069 215 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 16130774 Common ygeY predicted peptidase b2872 196 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 16132002 Common rlmB 23S rRNA (Gm2251)-methyltransferase b4180 215 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 145698309 Common insC KpLE2 phage-like element; IS2 insertion element repressor InsA b3044 39 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 16128878 Common rpsA 30S ribosomal subunit protein S1 b0911 217 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 16129687 Common chbG conserved protein b1733 57 COG3394 COG3394, Uncharacterized protein conserved in bacteria Function unknown 16131219 Common fusA protein chain elongation factor EF-G, GTP-binding b3340 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 16129282 Common ycjX conserved protein with nucleoside triphosphate hydrolase domain b1321 42 COG3106 COG3106, Predicted ATPase General function prediction only 16131619 Common rbsB D-ribose transporter subunit b3751 131 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 16128748 Common ybhK predicted transferase with NAD(P)-binding Rossmann-fold domain b0780 95 COG0391 COG0391, Uncharacterized conserved protein Function unknown 90111679 Common zur DNA-binding transcriptional repressor, Zn(II)-binding b4046 135 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 16128964 Common torD chaperone involved in maturation of TorA subunit of trimethylamine N-oxide reductase system I b0998 17 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 16130015 Common mdtB multidrug efflux system, subunit B b2075 181 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 90111415 Common yfbU conserved protein b2294 18 COG3013 COG3013, Uncharacterized conserved protein Function unknown 16129052 Common rpmF 50S ribosomal subunit protein L32 b1089 88 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 16131937 Common proP proline/glycine betaine transporter b4111 163 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16129186 Common narK nitrate/nitrite transporter b1223 72 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 16129229 Common yciQ predicted inner membrane protein b1268 10 None None None 90111381 Common mdtA multidrug efflux system, subunit A b2074 172 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 90111496 Common yqeJ predicted protein b2848 4 None None None 16128017 Common rpsT 30S ribosomal subunit protein S20 b0023 206 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 16128962 Common torC trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit b0996 51 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 16130261 Common yfcM conserved protein b2326 31 COG3101 COG3101, Uncharacterized protein conserved in bacteria Function unknown 90111517 Common yggR predicted transporter b2950 214 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 16130953 Common bacA undecaprenyl pyrophosphate phosphatase b3057 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 16128361 Common ampH beta-lactamase/D-alanine carboxypeptidase b0376 109 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 16129493 Common ydeE predicted transporter b1534 66 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16129559 Common tqsA predicted inner membrane protein b1601 186 COG0628 PerM, Predicted permease General function prediction only 16130641 Common pphB serine/threonine-specific protein phosphatase 2 b2734 67 None None None 16129234 Common yciN predicted protein b1273 13 None None None 90111680 Common pspG phage shock protein G b4050 10 None None None 16131722 Common yihU predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain b3882 161 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 16132189 Common rsmC 16S rRNA m2G1207 methylase b4371 154 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 16130828 Common epd D-erythrose 4-phosphate dehydrogenase b2927 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 16129413 Common yncG predicted enzyme b1454 45 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 90111731 Common yjiH conserved inner membrane protein b4330 11 COG3314 COG3314, Uncharacterized protein conserved in bacteria Function unknown 16129700 Common astD succinylglutamic semialdehyde dehydrogenase b1746 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 16131226 Common fkpA FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) b3347 130 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 16131759 Common yiiR conserved inner membrane protein b3921 22 COG3152 COG3152, Predicted membrane protein Function unknown 16131752 Common cpxR DNA-binding response regulator in two-component regulatory system with CpxA b3912 221 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 16131086 Common yrbG predicted calcium/sodium:proton antiporter b3196 117 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 16130442 Common yfgB predicted enzyme b2517 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 16128125 Common yadD predicted transposase b0132 29 COG5464 COG5464, Uncharacterized conserved protein Function unknown 16128940 Common hyaC hydrogenase 1, b-type cytochrome subunit b0974 46 COG1969 HyaC, Ni,Fe-hydrogenase I cytochrome b subunit Energy production and conversion 16130219 Common nuoF NADH:ubiquinone oxidoreductase, chain F b2284 167 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 16129506 Common ydfN Qin prophage; predicted side tail fibre assembly protein b1547 9 None None None 145698285 Common rcsC hybrid sensory kinase in two-component regulatory system with RcsB and YojN b2218 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 16131317 Common insB IS1 transposase InsAB' b3445 20 COG1662 InsB, Transposase and inactivated derivatives, IS1 family DNA replication, recombination, and repair 16128161 Common map methionine aminopeptidase b0168 249 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 16130463 Common hcaE 3-phenylpropionate dioxygenase, large (alpha) subunit b2538 83 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 16129197 Common galU glucose-1-phosphate uridylyltransferase b1236 230 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 49176087 Common ldrA toxic polypeptide, small b4419 3 None None None 90111151 Common dsbG periplasmic disulfide isomerase/thiol-disulphide oxidase b0604 28 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 16130663 Common ygcH predicted protein b2756 32 None None None 90111256 Common sieB Rac prophage; phage superinfection exclusion protein b1353 1 COG2512 COG2512, Uncharacterized membrane-associated protein/domain Function unknown 90111729 Common fimI fimbrial protein involved in type 1 pilus biosynthesis b4315 20 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16131113 Common nanE predicted N-acetylmannosamine-6-P epimerase b3223 43 COG3010 NanE, Putative N-acetylmannosamine-6-phosphate epimerase Carbohydrate transport and metabolism 16132070 Common yjgH predicted mRNA endoribonuclease b4248 75 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 16129959 Nonpathogen hisL his operon leader peptide b2018 1 None None None 90111745 Common yjjV predicted DNase b4378 237 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 16128436 Common amtB ammonium transporter b0451 201 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 16130227 Common yfbS predicted transporter b2292 122 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 90111216 Common ymfA predicted inner membrane protein b1122 2 None None None 90111220 Nonpathogen ymfI e14 prophage; predicted protein b1143 1 None None None 90111417 Common dedD conserved protein b2314 21 COG3147 DedD, Uncharacterized protein conserved in bacteria Function unknown 16129037 Common flgC flagellar component of cell-proximal portion of basal-body rod b1074 126 COG1558 FlgC, Flagellar basal body rod protein Cell motility and secretion 16129483 Common yneH predicted glutaminase b1524 72 COG2066 GlsA, Glutaminase Amino acid transport and metabolism 16131794 Common ppc phosphoenolpyruvate carboxylase b3956 117 COG2352 Ppc, Phosphoenolpyruvate carboxylase Energy production and conversion 16128614 Common ybeD conserved protein b0631 47 COG2921 COG2921, Uncharacterized conserved protein Function unknown 16130105 Common fruA fused fructose-specific PTS enzymes: IIBcomponent/IIC components b2167 68 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 16131693 Common pepQ proline dipeptidase b3847 183 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 16132196 Common yjjW predicted pyruvate formate lyase activating enzyme b4379 72 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 16129660 Common aroH 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible b1704 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 145698275 Common ydjM predicted inner membrane protein regulated by LexA b1728 36 COG1988 COG1988, Predicted membrane-bound metal-dependent hydrolases General function prediction only 16130634 Common hypB GTP hydrolase involved in nickel liganding into hydrogenases b2727 136 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 16129669 Common pheT phenylalanine tRNA synthetase, beta subunit b1713 245 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 16132023 Common priB primosomal protein N b4201 25 COG2965 PriB, Primosomal replication protein N DNA replication, recombination, and repair 16129065 Common fhuE ferric-rhodotorulic acid outer membrane transporter b1102 108 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 16128856 Common lrp DNA-binding transcriptional dual regulator, leucine-binding b0889 157 COG1522 Lrp, Transcriptional regulators Transcription 16130782 Common ygfM predicted oxidoreductase b2880 19 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 90111238 Common yciG predicted protein b1259 12 None None None 16131307 Common asd aspartate-semialdehyde dehydrogenase, NAD(P)-binding b3433 195 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 16129876 Common yedE predicted inner membrane protein b1929 46 COG2391 COG2391, Predicted transporter component General function prediction only 16131211 Common gspK general secretory pathway component, cryptic b3332 31 COG3156 PulK, Type II secretory pathway, component PulK Intracellular trafficking and secretion 16129617 Common ydhB predicted DNA-binding transcriptional regulator b1659 163 COG0583 LysR, Transcriptional regulator Transcription 16130880 Common glcC DNA-binding transcriptional dual regulator, glycolate-binding b2980 129 COG2186 FadR, Transcriptional regulators Transcription 16128975 Common rutD predicted hydrolase b1009 70 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 33347812 Common thiG thiamin biosynthesis ThiGH complex subunit b3991 167 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 16131197 Common rplW 50S ribosomal subunit protein L23 b3318 138 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 16131792 Common yijO predicted DNA-binding transcriptional regulator b3954 118 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 16131372 Common gor glutathione oxidoreductase b3500 244 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 90111271 Common ydcH predicted protein b1426 23 COG2841 COG2841, Uncharacterized protein conserved in bacteria Function unknown 16131169 Common trkA NAD-binding component of TrK potassium transporter b3290 152 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 16131680 Common udp uridine phosphorylase b3831 100 COG2820 Udp, Uridine phosphorylase Nucleotide transport and metabolism 49176355 Common gntU gluconate transporter, low affinity GNT 1 system b4476 78 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 16130744 Common ygeA predicted racemase b2840 79 COG1794 RacX, Aspartate racemase Cell envelope biogenesis, outer membrane 90111170 Common ybiX conserved protein b0804 45 COG3128 PiuC, Uncharacterized iron-regulated protein Function unknown 16131888 Common soxS DNA-binding transcriptional dual regulator b4062 137 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16131718 Common yihQ alpha-glucosidase b3878 82 COG1501 COG1501, Alpha-glucosidases, family 31 of glycosyl hydrolases Carbohydrate transport and metabolism 16132083 Common yjgP conserved inner membrane protein b4261 74 COG0795 COG0795, Predicted permeases General function prediction only 16131180 Common rplO 50S ribosomal subunit protein L15 b3301 70 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 16129360 Common paaX DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive b1399 32 COG3327 PaaX, Phenylacetic acid-responsive transcriptional repressor Transcription 16131037 Common yraK predicted fimbrial-like adhesin protein b3145 6 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16130850 Common yqgF predicted Holliday junction resolvase b2949 184 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 90111179 Common ybjT conserved protein with NAD(P)-binding Rossmann-fold domain b0869 132 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 16129960 Common hisG ATP phosphoribosyltransferase b2019 204 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 16130340 Common cysK cysteine synthase A, O-acetylserine sulfhydrolase A subunit b2414 219 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 16132056 Common yjgA conserved protein b4234 61 COG3028 COG3028, Uncharacterized protein conserved in bacteria Function unknown 16130518 Common raiA cold shock protein associated with 30S ribosomal subunit b2597 91 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 16129641 Common ydiH predicted protein b1685 7 None None None 16129244 Common osmB lipoprotein b1283 6 None None None 16132140 Common fimG minor component of type 1 fimbriae b4319 12 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16131974 Common blc outer membrane lipoprotein (lipocalin) b4149 69 COG3040 Blc, Bacterial lipocalin Cell envelope biogenesis, outer membrane 145698282 Common insC KpLE2 phage-like element; IS2 insertion element repressor InsA b1997 39 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 145698345 Common yjiK conserved protein b4333 9 COG3204 COG3204, Uncharacterized protein conserved in bacteria Function unknown 16128201 Common rnhA ribonuclease HI, degrades RNA of DNA-RNA hybrids b0214 178 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 16128631 Common ybeU predicted tRNA ligase b0648 6 None None None 49176488 Common fimC chaperone, periplasmic b4316 24 COG3121 FimC, P pilus assembly protein, chaperone PapD Cell motility and secretion / Intracellular trafficking and secretion 16131470 Common mtlA fused mannitol-specific PTS enzymes: IIA components/IIB components/IIC components b3599 71 COG2213 MtlA, Phosphotransferase system, mannitol-specific IIBC component Carbohydrate transport and metabolism 16128633 Common hscC Hsp70 family chaperone Hsc62, binds to RpoD and inhibits transcription b0650 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 16128827 Common rumB 23S rRNA m(5)U747 methyltransferase b0859 182 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 90111460 Common yfhH predicted DNA-binding transcriptional regulator b2561 128 COG1737 RpiR, Transcriptional regulators Transcription 49176157 Common yebR conserved protein b1832 81 COG1956 COG1956, GAF domain-containing protein Signal transduction mechanisms 90111287 Common yneE conserved inner membrane protein b1520 56 COG3781 COG3781, Predicted membrane protein Function unknown 16130236 Common yfcF predicted enzyme b2301 56 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 16132120 Common yjhI KpLE2 phage-like element; predicted DNA-binding transcriptional regulator b4299 110 COG1414 IclR, Transcriptional regulator Transcription 16132205 Common serB 3-phosphoserine phosphatase b4388 155 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 16130346 Common yfeS conserved protein b2420 14 COG4884 COG4884, Uncharacterized protein conserved in bacteria Function unknown 16131152 Common envR DNA-binding transcriptional regulator b3264 83 COG1309 AcrR, Transcriptional regulator Transcription 16130546 Common yfjL CP4-57 prophage; predicted protein b2628 4 None None None 16131468 Common yibH predicted protein b3597 139 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 16130859 Common yggN predicted protein b2958 14 None None None 16129311 Common recE Rac prophage; exonuclease VIII, 5' -> 3' specific dsDNA exonuclease b1350 13 None None None 16130912 Common yqhH predicted outer membrane lipoprotein b3014 12 COG4238 COG4238, Murein lipoprotein Cell envelope biogenesis, outer membrane 16128111 Common acnB bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase b0118 211 COG1049 AcnB, Aconitase B Energy production and conversion 16130969 Common ygjH conserved protein b3074 165 COG0073 ARC1, EMAP domain General function prediction only 16129443 Common ddpD D-ala-D-ala transporter subunit b1484 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 16132038 Common ytfJ predicted transcriptional regulator b4216 18 COG3054 COG3054, Predicted transcriptional regulator General function prediction only 16129003 Common csgD DNA-binding transcriptional activator in two-component regulatory system b1040 145 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 49176400 Common kup potassium transporter b3747 88 COG3158 Kup, K+ transporter Inorganic ion transport and metabolism 16129498 Common ydfG L-allo-threonine dehydrogenase, NAD(P)-binding b1539 237 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 16128604 Common dcuC anaerobic C4-dicarboxylate transport b0621 24 COG3069 DcuC, C4-dicarboxylate transporter Energy production and conversion 90111140 Common ybaQ predicted DNA-binding transcriptional regulator b0483 72 COG3093 VapI, Plasmid maintenance system antidote protein General function prediction only 16129501 Common ydfI predicted mannonate dehydrogenase b1542 90 COG0246 MtlD, Mannitol-1-phosphate/altronate dehydrogenases Carbohydrate transport and metabolism 145698240 Common yccB hypothetical protein b4592 3 None None None 16129919 Common yodA conserved metal-binding protein b1973 19 COG3443 COG3443, Predicted periplasmic or secreted protein General function prediction only 16128348 Common yaiP predicted glucosyltransferase b0363 112 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 16131950 Common dcuR DNA-binding response regulator in two-component regulatory system with DcuS b4124 148 COG4565 CitB, Response regulator of citrate/malate metabolism Transcription / Signal transduction mechanisms 16128023 Common ispH 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein b0029 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 16129265 Common pspA regulatory protein for phage-shock-protein operon b1304 65 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 49176375 Common yiaN predicted transporter b3578 121 COG1593 DctQ, TRAP-type C4-dicarboxylate transport system, large permease component Carbohydrate transport and metabolism 16128075 Common mraW S-adenosyl-dependent methyltransferase activity on membrane-located substrates b0082 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 16128226 Common crl DNA-binding transcriptional regulator b0240 13 None None None 16128696 Common sdhC succinate dehydrogenase, membrane subunit, binds cytochrome b556 b0721 92 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 16132048 Common ppa inorganic pyrophosphatase b4226 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 90111698 Common rnr exoribonuclease R, RNase R b4179 204 COG0557 VacB, Exoribonuclease R Transcription 16130934 Common ygiC predicted enzyme b3038 54 COG0754 Gsp, Glutathionylspermidine synthase Amino acid transport and metabolism 16129520 Common rem Qin prophage; predicted protein b1561 2 None None None 16128370 Common adrA predicted diguanylate cyclase b0385 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 16131360 Common yhiJ predicted protein b3488 2 None None None 16129309 Common lar Rac prophage; restriction alleviation protein b1348 2 None None None 16128000 Common yaaA conserved protein b0006 84 COG3022 COG3022, Uncharacterized protein conserved in bacteria Function unknown 16128199 Common gloB predicted hydroxyacylglutathione hydrolase b0212 207 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 90111373 Common hisB fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase b2022 218 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 16129949 Common yeeA conserved inner membrane protein b2008 23 COG1289 COG1289, Predicted membrane protein Function unknown 16131508 Common rpmB 50S ribosomal subunit protein L28 b3637 159 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 16129795 Common holE DNA polymerase III, theta subunit b1842 12 None None None 16131404 Common bcsB regulator of cellulose synthase, cyclic di-GMP binding b3532 20 None None None 90111248 Common ycjR predicted enzyme b1314 69 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 90111149 Common ybcV DLP12 prophage; predicted protein b0558 4 COG5562 COG5562, Phage envelope protein General function prediction only 16129744 Common yeaM predicted DNA-binding transcriptional regulator b1790 69 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 90111136 Common cof thiamin pyrimidine pyrophosphate hydrolase b0446 107 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 16128588 Common ahpC alkyl hydroperoxide reductase, C22 subunit b0605 216 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 16132161 Common yjiR fused predicted DNA-binding transcriptional regulator/predicted aminotransferase b4340 225 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 16129046 Common flgL flagellar hook-filament junction protein b1083 102 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 16128082 Common ftsW integral membrane protein involved in stabilizing FstZ ring during cell division b0089 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 90111520 Common mltC membrane-bound lytic murein transglycosylase C b2963 127 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 16131957 Common cadA lysine decarboxylase 1 b4131 88 COG1982 LdcC, Arginine/lysine/ornithine decarboxylases Amino acid transport and metabolism 16131678 Common metE 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase b3829 142 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 16131990 Common yjeE ATPase with strong ADP affinity b4168 208 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 16128474 Common ybbL predicted transporter subunit: ATP-binding component of ABC superfamily b0490 249 COG4619 COG4619, ABC-type uncharacterized transport system, ATPase component General function prediction only 16130283 Common yfdH CPS-53 (KpLE1) prophage; bactoprenol glucosyl transferase b2351 178 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 90111627 Common yicG conserved inner membrane protein b3646 114 COG2860 COG2860, Predicted membrane protein Function unknown 16128539 Common rzpD DLP12 prophage; predicted murein endopeptidase b0556 9 None None None 49176125 Common manA mannose-6-phosphate isomerase b1613 41 COG1482 ManA, Phosphomannose isomerase Carbohydrate transport and metabolism 49176261 Common srlE glucitol/sorbitol-specific enzyme IIB component of PTS b2703 22 COG3732 SrlE, Phosphotransferase system sorbitol-specific component IIBC Carbohydrate transport and metabolism 90111593 Common ugpC glycerol-3-phosphate transporter subunit b3450 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 16129812 Common znuB zinc transporter subunit: membrane component of ABC superfamily b1859 181 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 16128496 Common allB allantoinase b0512 211 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 90111585 Common yrfG predicted hydrolase b3399 39 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 16128638 Common gltI glutamate and aspartate transporter subunit b0655 149 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 16129980 Common rfbD dTDP-4-dehydrorhamnose reductase subunit, NAD(P)-binding, of dTDP-L-rhamnose synthase b2040 170 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 162135892 Common pcnB poly(A) polymerase I b0143 211 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 16129019 Common yceI predicted protein b1056 114 COG2353 COG2353, Uncharacterized conserved protein Function unknown 16128804 Common bssR conserved protein b0836 6 None None None 16131073 Common obgE GTPase involved in cell partioning and DNA repair b3183 230 COG0536 Obg, Predicted GTPase General function prediction only 16131903 Common gltP glutamate/aspartate:proton symporter b4077 161 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 90111404 Common yfaT predicted protein b2229 13 COG3234 COG3234, Uncharacterized protein conserved in bacteria Function unknown 90111685 Common rpiR DNA-binding transcriptional repressor b4089 92 COG1737 RpiR, Transcriptional regulators Transcription 16131238 Common argD bifunctional acetylornithine aminotransferase/ succinyldiaminopimelate aminotransferase b3359 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 16128009 Common dnaJ chaperone Hsp40, co-chaperone with DnaK b0015 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 16128894 Common ycbL predicted metal-binding enzyme b0927 222 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 16130069 Common osmF predicted transporter subunit: periplasmic-binding component of ABC superfamily b2131 90 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 90111428 Common yfeA predicted diguanylate cyclase b2395 163 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 16128701 Common sucA 2-oxoglutarate decarboxylase, thiamin-requiring b0726 147 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 16129808 Common lpxM myristoyl-acyl carrier protein (ACP)-dependent acyltransferase b1855 84 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 16128809 Common ybjG undecaprenyl pyrophosphate phosphatase b0841 68 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 16130551 Common yfjQ CP4-57 prophage; predicted protein b2633 23 None None None 16129278 Common ycjU predicted beta-phosphoglucomutase b1317 164 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 162135914 Common yicR protein associated with replication fork, possible DNA repair protein b3638 179 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 16130697 Common yqcA predicted flavoprotein b2790 69 COG0716 FldA, Flavodoxins Energy production and conversion 16128689 Common nei endonuclease VIII/ 5-formyluracil/5-hydroxymethyluracil DNA glycosylase b0714 150 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 16130844 Common galP D-galactose transporter b2943 203 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16130845 Common yggI conserved protein b2944 26 COG3091 SprT, Uncharacterized protein conserved in bacteria Function unknown 16129291 Common ynaI conserved inner membrane protein b1330 176 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 90111493 Common ygdB predicted protein b2824 6 None None None 16131201 Common gspB part of gsp divergon involved in type II protein secretion b3322 2 None None None 16129761 Common yeaZ predicted peptidase b1807 166 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 16130369 Nonpathogen yffM CPZ-55 prophage; predicted protein b2444 1 None None None 90111544 Common yhaB predicted protein b3120 2 None None None 49176417 Common yigE predicted protein b4482 24 COG3698 COG3698, Predicted periplasmic protein Function unknown 145698245 Common ycgN conserved protein b1181 75 COG2983 COG2983, Uncharacterized conserved protein Function unknown 16128519 Common fimZ predicted DNA-binding transcriptional regulator b0535 195 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 16130225 Common yfbQ predicted aminotransferase b2290 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 16128704 Common sucD succinyl-CoA synthetase, NAD(P)-binding, alpha subunit b0729 216 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 90111734 Common yjiL predicted ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase b4334 65 COG1924 COG1924, Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) Lipid metabolism 16131352 Common nikE nickel transporter subunit b3480 249 COG1124 DppF, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 90111361 Common yedR predicted inner membrane protein b1963 3 None None None 16131544 Common yidF predicted DNA-binding transcriptional regulator b3674 10 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 16131890 Common yjcD predicted permease b4064 134 COG2252 COG2252, Permeases General function prediction only 16130958 Common ttdB L-tartrate dehydratase, beta subunit b3062 148 COG1838 FumA, Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain Energy production and conversion 16131874 Common yjbM predicted protein b4048 2 None None None 16130494 Common lepA GTP-binding membrane protein b2569 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 145698324 Common bcsC cellulose synthase subunit b3530 65 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 16130272 Common yfcV predicted fimbrial-like adhesin protein b2339 5 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16128228 Common proB gamma-glutamate kinase b0242 192 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 16129295 Common fnr DNA-binding transcriptional dual regulator, global regulator of anaerobic growth b1334 159 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 16129675 Common thrS threonyl-tRNA synthetase b1719 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 145698253 Common paaD predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation b1391 53 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 16129718 Common selD selenophosphate synthase b1764 147 COG0709 SelD, Selenophosphate synthase Amino acid transport and metabolism 16132041 Common msrA methionine sulfoxide reductase A b4219 205 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 16130383 Common eutD predicted phosphotransacetylase subunit b2458 165 COG0280 Pta, Phosphotransacetylase Energy production and conversion 162135908 Common tdcR DNA-binding transcriptional activator b3119 2 None None None 16129426 Common narY nitrate reductase 2 (NRZ), beta subunit b1467 150 COG1140 NarY, Nitrate reductase beta subunit Energy production and conversion 16129579 Common malX fused maltose and glucose-specific PTS enzymes: IIB component -! IIC component b1621 49 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 16131768 Common menA 1,4-dihydroxy-2-naphthoate octaprenyltransferase b3930 104 COG1575 MenA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase Coenzyme metabolism 16129354 Common paaF enoyl-CoA hydratase-isomerase b1393 180 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 90111710 Common yjfF predicted sugar transporter subunit: membrane component of ABC superfamily b4231 126 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 16128814 Common ybjK predicted DNA-binding transcriptional regulator b0846 29 COG3226 COG3226, Uncharacterized protein conserved in bacteria Function unknown 16131815 Common rplJ 50S ribosomal subunit protein L10 b3985 205 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 16128883 Common ycaQ conserved protein b0916 61 COG3214 COG3214, Uncharacterized protein conserved in bacteria Function unknown 90111566 Common yhdJ predicted methyltransferase b3262 145 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 16129301 Common ydaL conserved protein b1340 73 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 16129637 Common sufD component of SufBCD complex b1681 176 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 16129990 Common wcaI predicted glycosyl transferase b2050 85 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 145698271 Common ydhX predicted 4Fe-4S ferridoxin-type protein b1671 164 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 90111616 Common yiaA conserved inner membrane protein b3562 13 COG4682 COG4682, Predicted membrane protein Function unknown 16131728 Common yiiD predicted acetyltransferase b3888 48 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 16128830 Common artQ arginine transporter subunit b0862 172 COG4215 ArtQ, ABC-type arginine transport system, permease component Amino acid transport and metabolism 16130690 Common chpR antitoxin of the ChpA-ChpR toxin-antitoxin system b2783 28 COG2336 MazE, Growth regulator Signal transduction mechanisms 16129565 Common ydgC conserved inner membrane protein associated with alginate biosynthesis b1607 14 COG3136 GlpM, Uncharacterized membrane protein required for alginate biosynthesis General function prediction only 162135905 Common pbpG D-alanyl-D-alanine endopeptidase b2134 152 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 16129572 Common ydgA conserved protein b1614 20 COG5339 COG5339, Uncharacterized protein conserved in bacteria Function unknown 16131034 Common yraH predicted fimbrial-like adhesin protein b3142 12 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16128526 Common emrE DLP12 prophage; multidrug resistance protein b0543 135 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 16129832 Common flhB predicted flagellar export pore protein b1880 130 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 16128574 Common entS predicted transporter b0591 63 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16128192 Common metN DL-methionine transporter subunit b0199 249 COG1135 AbcC, ABC-type metal ion transport system, ATPase component Inorganic ion transport and metabolism 16132115 Common insA KpLE2 phage-like element; IS1 repressor protein InsA b4294 13 COG3677 COG3677, Transposase and inactivated derivatives DNA replication, recombination, and repair 49176459 Common phnK carbon-phosphorus lyase complex subunit b4097 249 COG4107 PhnK, ABC-type phosphonate transport system, ATPase component Inorganic ion transport and metabolism 16129008 Common ymdB conserved protein b1045 116 COG2110 COG2110, Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 General function prediction only 90111696 Common rsgA ribosome small subunit-dependent GTPase A b4161 163 COG1162 COG1162, Predicted GTPases General function prediction only 16131774 Common rpmE 50S ribosomal subunit protein L31 b3936 182 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 90111158 Common ybeQ conserved protein b0644 110 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 16128734 Common ybhA predicted hydrolase b0766 106 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 90111573 Common yheO predicted DNA-binding transcriptional regulator b3346 48 COG2964 COG2964, Uncharacterized protein conserved in bacteria Function unknown 16131416 Common dppA dipeptide transporter b3544 212 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 16132017 Common ulaC L-ascorbate-specific enzyme IIA component of PTS b4195 46 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 16128260 Common insA KpLE2 phage-like element; IS1 repressor protein InsA b0275 14 COG3677 COG3677, Transposase and inactivated derivatives DNA replication, recombination, and repair 16131105 Common yhcA predicted periplasmic chaperone protein b3215 14 COG3121 FimC, P pilus assembly protein, chaperone PapD Cell motility and secretion / Intracellular trafficking and secretion 90111643 Common tnaA tryptophanase/L-cysteine desulfhydrase, PLP-dependent b3708 44 COG3033 TnaA, Tryptophanase Amino acid transport and metabolism 16130780 Common ygfK predicted oxidoreductase, Fe-S subunit b2878 208 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 16129609 Common gloA glyoxalase I, Ni-dependent b1651 127 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 16130906 Common metC cystathionine beta-lyase, PLP-dependent b3008 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 16130960 Common ygjD predicted peptidase b3064 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 16128185 Common nlpE lipoprotein involved with copper homeostasis and adhesion b0192 22 COG3015 CutF, Uncharacterized lipoprotein NlpE involved in copper resistance Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism 16129927 Common yeeN conserved protein b1983 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 16129693 Common osmE DNA-binding transcriptional activator b1739 11 COG2913 SmpA, Small protein A (tmRNA-binding) Translation, ribosomal structure and biogenesis 16128645 Common ubiF 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol oxygenase b0662 130 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 16129695 Common cho endonuclease of nucleotide excision repair b1741 217 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 16129178 Common kdsA 3-deoxy-D-manno-octulosonate 8-phosphate synthase b1215 186 COG2877 KdsA, 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase Cell envelope biogenesis, outer membrane 90111349 Common yecN predicted inner membrane protein b1869 30 COG3788 COG3788, Uncharacterized relative of glutathione S-transferase, MAPEG superfamily General function prediction only 16129954 Common yeeE predicted inner membrane protein b2013 86 COG2391 COG2391, Predicted transporter component General function prediction only 16128487 Common ybbB tRNA 2-selenouridine synthase, selenophosphate-dependent b0503 65 COG2603 COG2603, Predicted ATPase General function prediction only 16129119 Common tfaE e14 prophage; predicted tail fiber assembly protein b1156 10 None None None 16131818 Common rpoC RNA polymerase, beta prime subunit b3988 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 16131399 Common yhjJ predicted zinc-dependent peptidase b3527 49 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 16128299 Common betT choline transporter of high affinity b0314 96 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 16128440 Common ybaA conserved protein b0456 39 COG5507 COG5507, Uncharacterized conserved protein Function unknown 16128449 Common kefA fused conserved protein b0465 228 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 16129907 Common dcm DNA cytosine methylase b1961 122 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 16128394 Common secF SecYEG protein translocase auxillary subunit b0409 220 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 16128052 Common rluA pseudouridine synthase for 23S rRNA (position 746) and tRNAphe(position 32) b0058 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 16131592 Common phoU negative regulator of PhoR/PhoB two-component regulator b3724 194 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 90111335 Common yeaT predicted DNA-binding transcriptional regulator b1799 165 COG0583 LysR, Transcriptional regulator Transcription 16131855 Common yjbH predicted porin b4029 23 None None None 16128272 Common yagU conserved inner membrane protein b0287 16 COG3477 COG3477, Predicted periplasmic/secreted protein Function unknown 16131480 Common secB protein export chaperone b3609 107 COG1952 SecB, Preprotein translocase subunit SecB Intracellular trafficking and secretion 16129724 Common ydjF predicted DNA-binding transcriptional regulator b1770 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 16131304 Common glgC glucose-1-phosphate adenylyltransferase b3430 175 COG0448 GlgC, ADP-glucose pyrophosphorylase Carbohydrate transport and metabolism 90111718 Common yjhB KpLE2 phage-like element; predicted transporter b4279 206 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 90111435 Common ypeA predicted acyltransferase with acyl-CoA N-acyltransferase domain b2434 88 COG0456 RimI, Acetyltransferases General function prediction only 16129367 Common ydbC predicted oxidoreductase, NAD(P)-binding b1406 165 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 16128849 Common clpS regulatory protein for ClpA substrate specificity b0881 122 COG2127 COG2127, Uncharacterized conserved protein Function unknown 16130479 Common yfhA predicted DNA-binding response regulator in two-component system b2554 222 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 16129393 Common ydcN predicted DNA-binding transcriptional regulator b1434 101 COG1396 HipB, Predicted transcriptional regulators Transcription 16128900 Common ssuB alkanesulfonate transporter subunit b0933 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 16129978 Common rfbC dTDP-4-deoxyrhamnose-3,5-epimerase b2038 166 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 16131687 Common tatC TatABCE protein translocation system subunit b3839 205 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 16128066 Common leuC 3-isopropylmalate isomerase subunit, dehydratase component b0072 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 16128907 Common ycbS predicted outer membrane usher protein b0940 26 COG3188 FimD, P pilus assembly protein, porin PapC Cell motility and secretion / Intracellular trafficking and secretion 16129084 Common ycfZ predicted inner membrane protein b1121 1 COG1512 COG1512, Beta-propeller domains of methanol dehydrogenase type General function prediction only 16128147 Common hemL glutamate-1-semialdehyde aminotransferase (aminomutase) b0154 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 16129612 Common grxD conserved protein b1654 126 COG0278 COG0278, Glutaredoxin-related protein Posttranslational modification, protein turnover, chaperones 16131779 Common metF 5,10-methylenetetrahydrofolate reductase b3941 151 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 16132031 Common ytfE predicted regulator of cell morphogenesis and cell wall metabolism b4209 45 COG2846 COG2846, Regulator of cell morphogenesis and NO signaling Cell division and chromosome partitioning 16129041 Common flgG flagellar component of cell-distal portion of basal-body rod b1078 126 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 16130420 Common yfgD predicted oxidoreductase b2495 112 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 16131922 Common phnL carbon-phosphorus lyase complex subunit b4096 249 COG4778 PhnL, ABC-type phosphonate transport system, ATPase component Inorganic ion transport and metabolism 16130917 Common ygiT predicted DNA-binding transcriptional regulator b3021 16 COG2944 COG2944, Predicted transcriptional regulator Transcription 16130724 Common recB exonuclease V (RecBCD complex), beta subunit b2820 219 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 16128798 Common gsiB predicted peptide transporter subunit: periplasmic-binding component of ABC superfamily b0830 212 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 94541110 Common rzoR Rac prophage; predicted lipoprotein b4528 1 COG3417 FlgN, Collagen-binding surface adhesin SpaP (antigen I/II family) General function prediction only 16129089 Common potA polyamine transporter subunit b1126 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 90111210 Common yceQ predicted protein b1085 3 None None None 16130777 Common yqeB conserved protein with NAD(P)-binding Rossman fold b2875 119 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 16131757 Common tpiA triosephosphate isomerase b3919 227 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 16128543 Common nohB DLP12 prophage; DNA packaging protein b0560 10 COG4220 COG4220, Phage DNA packaging protein, Nu1 subunit of terminase DNA replication, recombination, and repair 16128399 Common ribD fused diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase b0414 230 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 16129997 Common wcaC predicted glycosyl transferase b2057 23 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 16131841 Common aceA isocitrate lyase b4015 128 COG2224 AceA, Isocitrate lyase Energy production and conversion 16128320 Common prpE predicted propionyl-CoA synthetase with ATPase domain b0335 216 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 16129897 Common fliR flagellar export pore protein b1950 119 COG1684 FliR, Flagellar biosynthesis pathway, component FliR Cell motility and secretion / Intracellular trafficking and secretion 16129335 Common pinR Rac prophage; predicted site-specific recombinase b1374 136 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 16129112 Common ymfN e14 prophage; predicted DNA-binding transcriptional regulator b1149 46 COG4626 COG4626, Phage terminase-like protein, large subunit General function prediction only 16130739 Common lplT predicted inner membrane protein b2835 75 None None None 16131975 Common ampC beta-lactamase/D-alanine carboxypeptidase b4150 125 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 16131061 Common nusA transcription termination/antitermination L factor b3169 216 COG0195 NusA, Transcription elongation factor Transcription 16131068 Common hflB protease, ATP-dependent zinc-metallo b3178 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 16131173 Common rplQ 50S ribosomal subunit protein L17 b3294 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 16131931 Common phnD phosphonate/organophosphate ester transporter subunit b4105 86 COG3221 PhnD, ABC-type phosphate/phosphonate transport system, periplasmic component Inorganic ion transport and metabolism 145698226 Common ybbJ conserved inner membrane protein b0488 40 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 16131958 Common cadB predicted lysine/cadaverine transporter b4132 167 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 16130161 Common atoB acetyl-CoA acetyltransferase b2224 167 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 16129611 Common lhr predicted ATP-dependent helicase b1653 153 COG1201 Lhr, Lhr-like helicases General function prediction only 16131829 Common yjaG conserved protein b3999 26 COG3068 COG3068, Uncharacterized protein conserved in bacteria Function unknown 16129038 Common flgD flagellar hook assembly protein b1075 106 COG1843 FlgD, Flagellar hook capping protein Cell motility and secretion 16130163 Common yfaQ predicted protein b2226 7 COG5445 COG5445, Predicted secreted protein Function unknown 16130825 Common mscS mechanosensitive channel b2924 198 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 16128960 Common torT periplasmic sensory protein associated with the TorRS two-component regulatory system b0994 37 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 90111209 Common mdtH predicted drug efflux system b1065 104 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16130472 Common yphE fused predicted sugar transporter subunits of ABC superfamily: ATP-binding components b2547 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 16129195 Common rssA conserved protein b1234 127 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 16130246 Common ubiX 3-octaprenyl-4-hydroxybenzoate carboxy-lyase b2311 151 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 145698296 Nonpathogen yffN CPZ-55 prophage; predicted protein b2445 1 None None None 16130449 Common iscX conserved protein b2524 43 COG2975 COG2975, Uncharacterized protein conserved in bacteria Function unknown 16130796 Common xerD site-specific tyrosine recombinase b2894 230 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 16130886 Common yghT predicted protein with nucleoside triphosphate hydrolase domain b2986 4 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 16128434 Common mdlB fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components b0449 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 90111225 Common ycgG conserved inner membrane protein b1168 163 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 49176401 Common yieP predicted transcriptional regulator b3755 126 COG2186 FadR, Transcriptional regulators Transcription 16129553 Common ynfL predicted DNA-binding transcriptional regulator b1595 191 COG0583 LysR, Transcriptional regulator Transcription 90111215 Common lolD outer membrane-specific lipoprotein transporter subunit b1117 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 49176424 Common yigL predicted hydrolase b3826 114 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 16130100 Common rihB ribonucleoside hydrolase 2 b2162 88 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 90111450 Common der predicted GTP-binding protein b2511 229 COG1160 COG1160, Predicted GTPases General function prediction only 16131320 Common yhhA conserved protein b3448 6 None None None 16130647 Common ygbN predicted transporter b2740 80 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 16131058 Common truB tRNA pseudouridine synthase b3166 245 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 16129931 Common erfK conserved protein with NAD(P)-binding Rossmann-fold domain b1990 86 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 94541092 Common yncN predicted protein b4532 6 None None None 16130559 Common yfjY CP4-57 prophage; predicted DNA repair protein b2644 178 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 16128255 Common yagG CP4-6 prophage; predicted sugar transporter b0270 79 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 16130593 Common proX glycine betaine transporter subunit b2679 50 COG2113 ProX, ABC-type proline/glycine betaine transport systems, periplasmic components Amino acid transport and metabolism 16128154 Common degP serine endoprotease (protease Do), membrane-associated b0161 223 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 49176423 Common pldB lysophospholipase L(2) b3825 74 COG2267 PldB, Lysophospholipase Lipid metabolism 16129524 Nonpathogen ydfV Qin prophage; predicted protein b1565 1 None None None 16131993 Common miaA delta(2)-isopentenylpyrophosphate tRNA-adenosine transferase b4171 214 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 16129063 Common ycfH predicted metallodependent hydrolase b1100 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 90111459 Common yfhB conserved protein b2560 11 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 16130344 Common pdxK pyridoxal-pyridoxamine kinase/hydroxymethylpyrimidine kinase b2418 128 COG2240 PdxK, Pyridoxal/pyridoxine/pyridoxamine kinase Coenzyme metabolism 90111344 Common pphA serine/threonine-specific protein phosphatase 1 b1838 93 COG0639 ApaH, Diadenosine tetraphosphatase and related serine/threonine protein phosphatases Signal transduction mechanisms 16131939 Common basR DNA-binding response regulator in two-component regulatory system with BasS b4113 218 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 16132194 Common osmY periplasmic protein b4376 84 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 16129451 Common gadC predicted glutamate:gamma-aminobutyric acid antiporter b1492 113 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 16130217 Common nuoH NADH:ubiquinone oxidoreductase, membrane subunit H b2282 186 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 16130067 Common yehX predicted transporter subunit: ATP-binding component of ABC superfamily b2129 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 16128314 Common yahO predicted protein b0329 7 None None None 145698278 Common yebF predicted protein b1847 8 None None None 16130396 Common yffB conserved protein b2471 104 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 16131758 Common yiiQ conserved protein b3920 11 None None None 16131420 Common tag 3-methyl-adenine DNA glycosylase I, constitutive b3549 132 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 16130209 Nonpathogen yfbO predicted protein b2274 1 None None None 16131737 Common frvR predicted regulator b3897 10 COG3711 BglG, Transcriptional antiterminator Transcription 16131052 Common yhbW predicted enzyme b3160 112 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 16129688 Common chbF cryptic phospho-beta-glucosidase, NAD(P)-binding b1734 53 COG1486 CelF, Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases Carbohydrate transport and metabolism 16129665 Common btuD vitamin B12 transporter subunit : ATP-binding component of ABC superfamily b1709 249 COG4138 BtuD, ABC-type cobalamin transport system, ATPase component Coenzyme metabolism 90111145 Common ybbY predicted uracil/xanthine transporter b0513 69 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 16130201 Common elaB conserved protein b2266 8 COG4575 ElaB, Uncharacterized conserved protein Function unknown 90111636 Common yidE predicted transporter b3685 56 COG2985 COG2985, Predicted permease General function prediction only 16132192 Common yjjG dUMP phosphatase b4374 112 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 16130637 Common hypE carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein b2730 139 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 16131115 Common nanA N-acetylneuraminate lyase b3225 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 16128246 Common mmuM CP4-6 prophage; S-methylmethionine:homocysteine methyltransferase b0261 137 COG2040 MHT1, Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) Amino acid transport and metabolism 16129667 Common btuC vitamin B12 transporter subunit: membrane component of ABC superfamily b1711 191 COG4139 BtuC, ABC-type cobalamin transport system, permease component Coenzyme metabolism 16129831 Common flhA predicted flagellar export pore protein b1879 127 COG1298 FlhA, Flagellar biosynthesis pathway, component FlhA Cell motility and secretion / Intracellular trafficking and secretion 16129103 Common intE e14 prophage; predicted integrase b1140 23 None None None 90111379 Common udk uridine/cytidine kinase b2066 99 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 90111615 Common yiaF conserved protein b3554 12 None None None 16129031 Common yceM predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain b1068 105 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 90111398 Common yeiA predicted oxidoreductase b2147 173 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 16130731 Common thyA thymidylate synthetase b2827 139 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 16129249 Common fabI enoyl-[acyl-carrier-protein] reductase, NADH-dependent b1288 231 COG0623 FabI, Enoyl- acyl-carrier-protein 16129981 Common rfbB dTDP-glucose 4,6 dehydratase, NAD(P)-binding b2041 231 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 16131491 Common rfaF ADP-heptose:LPS heptosyltransferase II b3620 106 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 16130632 Common hycA regulator of the transcriptional regulator FhlA b2725 7 None None None 16129171 Common ispE 4-diphosphocytidyl-2-C-methylerythritol kinase b1208 192 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 16131153 Common acrE cytoplasmic membrane lipoprotein b3265 150 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 16129285 Common tpx lipid hydroperoxide peroxidase b1324 111 COG2077 Tpx, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 16131041 Common diaA DnaA initiator-associating factor for replication initiation b3149 122 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 16130668 Common ygcB conserved protein, member of DEAD box family b2761 85 COG1203 COG1203, Predicted helicases General function prediction only 16132077 Common rraB conserved protein b4255 23 COG3076 COG3076, Uncharacterized protein conserved in bacteria Function unknown 90111386 Common yegX predicted hydrolase b2102 42 COG3757 Acm, Lyzozyme M1 (1,4-beta-N-acetylmuramidase) Cell envelope biogenesis, outer membrane 16129486 Common yneK predicted protein b1527 2 None None None 16130018 Common baeS sensory histidine kinase in two-component regulatory system with BaeR b2078 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 16132040 Common ytfL predicted inner membrane protein b4218 219 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 16129021 Common yceO predicted protein b1058 6 None None None 16129634 Common ynhG conserved protein b1678 89 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 16131834 Common zraR fused DNA-binding response regulator in two-component regulatory system with ZraS: response regulator/sigma54 interaction protein b4004 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 16130976 Common fadH 2,4-dienoyl-CoA reductase, NADH and FMN-linked b3081 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 16128745 Common bioC predicted methltransferase, enzyme of biotin synthesis b0777 162 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 16131837 Common yjaA conserved protein b4011 8 None None None 16130950 Common ygiF predicted adenylate cyclase b3054 58 COG3025 COG3025, Uncharacterized conserved protein Function unknown 16132133 Common fimB tyrosine recombinase/inversion of on/off regulator of fimA b4312 210 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 16130379 Common eutJ predicted chaperonin, ethanolamine utilization protein b2454 22 COG4820 EutJ, Ethanolamine utilization protein, possible chaperonin Amino acid transport and metabolism 16130650 Common pcm L-isoaspartate protein carboxylmethyltransferase type II b2743 158 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 16129676 Common ydiY conserved protein b1722 35 COG3137 COG3137, Putative salt-induced outer membrane protein Cell envelope biogenesis, outer membrane 16132004 Common yjfJ predicted transcriptional regulator effector protein b4182 19 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 16128360 Common yaiV predicted DNA-binding transcriptional regulator b0375 7 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 16128594 Common rna ribonuclease I b0611 32 COG3719 Rna, Ribonuclease I Translation, ribosomal structure and biogenesis 49176429 Common tatD DNase, magnesium-dependent b4483 229 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 94541138 Common yjhX conserved protein b4566 18 COG3811 COG3811, Uncharacterized protein conserved in bacteria Function unknown 16130904 Common exbB membrane spanning protein in TonB-ExbB-ExbD complex b3006 148 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 49176458 Common yjdP conserved protein b4487 3 None None None 90111412 Common rbn binuclear zinc phosphodiesterase b2268 134 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 16130805 Common gcvP glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex b2903 172 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 90111552 Common yhbX predicted hydrolase, inner membrane b3173 62 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 90111368 Common yeeR CP4-44 prophage; predicted membrane protein b2001 4 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 16131793 Common yijP conserved inner membrane protein b3955 53 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 145698235 Common gsiA fused predicted peptide transport subunits of ABC superfamily: ATP-binding components b0829 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 16130231 Common ackA acetate kinase A and propionate kinase 2 b2296 162 COG0282 ackA, Acetate kinase Energy production and conversion 16130466 Common hcaB 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase b2541 232 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 16131252 Common frlD fructoselysine 6-kinase b3374 162 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 16131120 Common rpsI 30S ribosomal subunit protein S9 b3230 249 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 16128884 Common ycaR conserved protein b0917 95 COG2835 COG2835, Uncharacterized conserved protein Function unknown 16131574 Common mnmE GTPase b3706 228 COG0486 ThdF, Predicted GTPase General function prediction only 16130596 Common mprA DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux b2684 89 COG1846 MarR, Transcriptional regulators Transcription 16130839 Common speA biosynthetic arginine decarboxylase, PLP-binding b2938 115 COG1166 SpeA, Arginine decarboxylase (spermidine biosynthesis) Amino acid transport and metabolism 16131141 Common yhdH predicted oxidoreductase, Zn-dependent and NAD(P)-binding b3253 94 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 16128212 Common dinJ predicted antitoxin of YafQ-DinJ toxin-antitoxin system b0226 34 COG3077 RelB, DNA-damage-inducible protein J DNA replication, recombination, and repair 16130334 Common yfeN conserved outer membrane protein b2408 8 None None None 16128970 Common wrbA predicted flavoprotein in Trp regulation b1004 106 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 16129202 Common adhE fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase b1241 175 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 16131569 Common dnaN DNA polymerase III, beta subunit b3701 215 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 16130143 Common napA nitrate reductase, periplasmic, large subunit b2206 184 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 90111079 Common caiF DNA-binding transcriptional activator b0034 4 None None None 16130308 Common ypdI predicted lipoprotein involved in colanic acid biosynthesis b2376 2 None None None 16130769 Common xdhB xanthine dehydrogenase, FAD-binding subunit b2867 104 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 94541104 Common gnsA predicted regulator of phosphatidylethanolamine synthesis b4517 4 None None None 16129250 Common ycjD conserved protein b1289 45 COG2852 COG2852, Uncharacterized protein conserved in bacteria Function unknown 16128308 Common yahI predicted carbamate kinase-like protein b0323 65 COG0549 ArcC, Carbamate kinase Amino acid transport and metabolism 16129400 Common ydcT predicted spermidine/putrescine transporter subunit b1441 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 16130800 Common ygfZ predicted folate-dependent regulatory protein b2898 101 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 90111567 Common yhdY predicted amino-acid transporter subunit b3270 175 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 90111485 Common ygcO predicted 4Fe-4S cluster-containing protein b2767 35 COG2440 FixX, Ferredoxin-like protein Energy production and conversion 16131161 Common yrdB conserved protein b3280 14 None None None 16131483 Common gpmM phosphoglycero mutase III, cofactor-independent b3612 125 COG0696 GpmI, Phosphoglyceromutase Carbohydrate transport and metabolism 16130584 Common ygaW predicted inner membrane protein b2670 13 None None None 16129738 Common yeaH conserved protein b1784 71 COG2718 COG2718, Uncharacterized conserved protein Function unknown 16128105 Common aroP aromatic amino acid transporter b0112 170 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 16128148 Common clcA chloride channel, voltage-gated b0155 153 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 90111305 Nonpathogen asr acid shock-inducible periplasmic protein b1597 1 None None None 16130086 Common mglC methyl-galactoside transporter subunit b2148 126 COG4211 MglC, ABC-type glucose/galactose transport system, permease component Carbohydrate transport and metabolism 16129485 Common yneJ predicted DNA-binding transcriptional regulator b1526 168 COG0583 LysR, Transcriptional regulator Transcription 16130538 Common yfjG conserved protein b2619 102 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 16129975 Nonpathogen rfc O-antigen polymerase b2035 1 None None None 16130440 Common ispG 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase b2515 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 90111419 Common prmB N5-glutamine methyltransferase b2330 223 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 16128801 Common yliE conserved inner membrane protein b0833 162 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 16128375 Common aroM conserved protein b0390 14 None None None 145698269 Common ydhM predicted DNA-binding transcriptional regulator b1649 81 COG1309 AcrR, Transcriptional regulator Transcription 16129760 Common yeaY predicted lipoprotein b1806 29 COG3065 Slp, Starvation-inducible outer membrane lipoprotein Cell envelope biogenesis, outer membrane 145698298 Nonpathogen yffS CPZ-55 prophage; predicted protein b2450 1 None None None 16131869 Common lexA DNA-binding transcriptional repressor of SOS regulon b4043 173 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 90111494 Common yqeF predicted acyltransferase b2844 183 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 16130655 Common ftsB cell division protein b2748 64 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 16129081 Common lolE outer membrane-specific lipoprotein transporter subunit b1118 183 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 49176447 Common pflC pyruvate formate lyase II activase b3952 62 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 16130935 Common ygiD predicted dioxygenase b3039 86 COG3384 COG3384, Uncharacterized conserved protein Function unknown 90111579 Common yhfU predicted protein b3378 11 COG1315 COG1315, Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain DNA replication, recombination, and repair 90111673 Common nfi endonuclease V b3998 73 COG1515 Nfi, Deoxyinosine 3'endonuclease (endonuclease V) DNA replication, recombination, and repair 16130454 Common iscU scaffold protein b2529 154 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 16128567 Common fepA iron-enterobactin outer membrane transporter b0584 109 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 16130503 Common eamB neutral amino-acid efflux system b2578 92 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 16129710 Common ynjD predicted transporter subunit: ATP-binding component of ABC superfamily b1756 249 COG4136 COG4136, ABC-type uncharacterized transport system, ATPase component General function prediction only 16131323 Common ugpE glycerol-3-phosphate transporter subunit b3451 145 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 16128456 Common recR gap repair protein b0472 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 90111157 Common ybeB predicted protein b0637 201 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 16131684 Common ubiB 2-octaprenylphenol hydroxylase b3835 185 COG0661 AarF, Predicted unusual protein kinase General function prediction only 16128983 Common ycdB conserved protein b1019 37 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 16129210 Common cls cardiolipin synthase 1 b1249 148 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 16128032 Common caiB crotonobetainyl CoA:carnitine CoA transferase b0038 111 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 16128231 Common yafW CP4-6 prophage; antitoxin of the YkfI-YafW toxin-antitoxin system b0246 10 None None None 16128151 Common btuF vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily b0158 139 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 16128123 Common yadE predicted polysaccharide deacetylase lipoprotein b0130 86 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 145698262 Common yddV predicted diguanylate cyclase b1490 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 67005950 Common trxA thioredoxin 1 b3781 233 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 16128946 Common appA phosphoanhydride phosphorylase b0980 17 None None None 16130608 Common mltB membrane-bound lytic murein transglycosylase B b2701 107 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 16129128 Common ymgA predicted protein b1165 2 None None None 16132166 Common mcrC 5-methylcytosine-specific restriction enzyme McrBC, subunit McrC b4345 11 COG4268 McrC, McrBC 5-methylcytosine restriction system component Defense mechanisms 49176341 Common frlC predicted isomerase b4474 48 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 16131842 Common aceK isocitrate dehydrogenase kinase/phosphatase b4016 29 COG4579 COG4579, Isocitrate dehydrogenase kinase/phosphatase Signal transduction mechanisms 16129199 Common tdk thymidine kinase/deoxyuridine kinase b1238 91 COG1435 Tdk, Thymidine kinase Nucleotide transport and metabolism 16129656 Common ydiT predicted 4Fe-4S ferredoxin-type protein b1700 33 COG2440 FixX, Ferredoxin-like protein Energy production and conversion 16128928 Common yccF conserved inner membrane protein b0961 42 COG3304 COG3304, Predicted membrane protein Function unknown 16130793 Common prfB peptide chain release factor RF-2 b2891 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 16128770 Common ybiJ predicted protein b0802 11 None None None 16128791 Common ybiW predicted pyruvate formate lyase b0823 59 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 16129075 Common bhsA predicted protein b1112 11 None None None 162135898 Common rluE 23S rRNA pseudouridine synthase b1135 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 16130838 Common speB agmatinase b2937 152 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 16128448 Common acrR DNA-binding transcriptional repressor b0464 136 COG1309 AcrR, Transcriptional regulator Transcription 16130687 Common pyrG CTP synthetase b2780 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 90111477 Common ygaF predicted enzyme b2660 122 COG0579 COG0579, Predicted dehydrogenase General function prediction only 16131862 Common lamB maltose outer membrane porin (maltoporin) b4036 26 COG4580 LamB, Maltoporin (phage lambda and maltose receptor) Carbohydrate transport and metabolism 16131961 Common dipZ fused thiol:disulfide interchange protein: activator of DsbC/conserved protein b4136 119 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 16129865 Common yecS predicted transporter subunit: membrane component of ABC superfamily b1918 172 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 90111383 Common yegR predicted protein b2085 3 None None None 16129857 Common tyrP tyrosine transporter b1907 33 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 16129966 Common hisF imidazole glycerol phosphate synthase, catalytic subunit with HisH b2025 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 16131047 Common yhbQ predicted endonuclease b3155 74 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 94541123 Common ypjJ predicted protein b4548 4 None None None 49176004 Common yaeP conserved protein b4406 12 None None None 16131145 Common yhdT conserved inner membrane protein b3257 13 COG3924 COG3924, Predicted membrane protein Function unknown 90111350 Common torZ trimethylamine N-oxide reductase system III, catalytic subunit b1872 171 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 16130191 Common yfbH conserved protein b2256 19 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 16128477 Common ybbO predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain b0493 233 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 16130751 Common yqeI predicted transcriptional regulator b2847 12 COG3710 CadC, DNA-binding winged-HTH domains Transcription 16131182 Common rpsE 30S ribosomal subunit protein S5 b3303 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 90111106 Common afuC CP4-6 prophage; predicted ferric transporter subunit b0262 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 16131715 Common ompL predicted outer membrane porin L b3875 5 None None None 16128328 Common lacY lactose/galactose transporter b0343 27 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 16128264 Common yagM CP4-6 prophage; predicted protein b0279 2 None None None 16130576 Common gabT 4-aminobutyrate aminotransferase, PLP-dependent b2662 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 16132055 Common mpl UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase b4233 208 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 16130136 Common ccmC heme exporter subunit b2199 124 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 16130254 Common usg predicted semialdehyde dehydrogenase b2319 167 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 16132081 Common holC DNA polymerase III, chi subunit b4259 41 COG2927 HolC, DNA polymerase III, chi subunit DNA replication, recombination, and repair 16131924 Common phnJ carbon-phosphorus lyase complex subunit b4098 45 COG3627 PhnJ, Uncharacterized enzyme of phosphonate metabolism Inorganic ion transport and metabolism 16131438 Common xylG fused D-xylose transporter subunits of ABC superfamily: ATP-binding components b3567 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 16130139 Common napC nitrate reductase, cytochrome c-type, periplasmic b2202 49 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 90111570 Common gspI general secretory pathway component, cryptic b3330 14 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 16130364 Common eutL predicted carboxysome structural protein with predicted role in ethanolamine utilization b2439 20 COG4816 EutL, Ethanolamine utilization protein Amino acid transport and metabolism 16130125 Common yejL conserved protein b2187 21 COG3082 COG3082, Uncharacterized protein conserved in bacteria Function unknown 16129000 Common csgG outer membrane lipoprotein b1037 18 COG1462 CsgG, Uncharacterized protein involved in formation of curli polymers Cell envelope biogenesis, outer membrane 16131764 Common glpK glycerol kinase b3926 179 COG0554 GlpK, Glycerol kinase Energy production and conversion 90111230 Common cvrA predicted cation/proton antiporter b1191 110 COG3263 COG3263, NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain Inorganic ion transport and metabolism 16128468 Common copA copper transporter b0484 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 16129358 Common paaJ predicted beta-ketoadipyl CoA thiolase b1397 184 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 94541118 Common yeiW conserved protein b4502 34 None None None 16128778 Common glnP glutamine transporter subunit b0810 172 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 16131294 Common malT fused conserved protein: DNA-binding transcriptional activator/maltotriose-ATP-binding protein b3418 87 COG2909 MalT, ATP-dependent transcriptional regulator Transcription 145698242 Nonpathogen ymgG predicted protein b1172 1 None None None 16129026 Common yceB predicted lipoprotein b1063 19 None None None 16128492 Common hyi hydroxypyruvate isomerase b0508 83 COG3622 Hfi, Hydroxypyruvate isomerase Carbohydrate transport and metabolism 16130212 Common nuoM NADH:ubiquinone oxidoreductase, membrane subunit M b2277 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 94541091 Common ydaF Rac prophage; predicted protein b4527 4 None None None 16130611 Common srlB glucitol/sorbitol-specific enzyme IIA component of PTS b2704 22 COG3731 SrlB, Phosphotransferase system sorbitol-specific component IIA Carbohydrate transport and metabolism 16130097 Common nfo endonuclease IV with intrinsic 3'-5' exonuclease activity b2159 99 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 16128300 Common yahA predicted DNA-binding transcriptional regulator b0315 162 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 16130314 Common ypdC predicted DNA-binding protein b2382 110 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16132214 Common creA conserved protein b4397 57 COG3045 CreA, Uncharacterized protein conserved in bacteria Function unknown 16131456 Common yiaU predicted DNA-binding transcriptional regulator b3585 141 COG0583 LysR, Transcriptional regulator Transcription 16129707 Common ynjA conserved protein b1753 27 COG2128 COG2128, Uncharacterized conserved protein Function unknown 16131380 Common yhiD predicted Mg(2+) transport ATPase inner membrane protein b3508 119 COG1285 SapB, Uncharacterized membrane protein Function unknown 90111239 Common trpC fused indole-3-glycerolphosphate synthetase/N-(5-phosphoribosyl)anthranilate isomerase b1262 220 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 16130033 Common gatZ D-tagatose 1,6-bisphosphate aldolase 2, subunit b2095 34 COG4573 GatZ, Predicted tagatose 6-phosphate kinase Carbohydrate transport and metabolism 16129371 Common ynbC predicted hydrolase b1410 72 COG2267 PldB, Lysophospholipase Lipid metabolism 16131904 Common yjcO conserved protein b4078 60 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 90111081 Common fixA predicted electron transfer flavoprotein subunit, ETFP adenine nucleotide-binding domain b0041 149 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 16131913 Common alsA fused D-allose transporter subunits of ABC superfamily: ATP-binding components b4087 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 90111116 Common mhpD 2-keto-4-pentenoate hydratase b0350 68 COG3971 COG3971, 2-keto-4-pentenoate hydratase Secondary metabolites biosynthesis, transport, and catabolism 16130337 Common ligA DNA ligase, NAD(+)-dependent b2411 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 49176414 Common yifK predicted transporter b3795 124 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 145698258 Common yncL hypothetical protein b4598 2 None None None 16131603 Common atpH F1 sector of membrane-bound ATP synthase, delta subunit b3735 174 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 16131561 Common dgoK 2-oxo-3-deoxygalactonate kinase b3693 41 COG3734 DgoK, 2-keto-3-deoxy-galactonokinase Carbohydrate transport and metabolism 49176463 Common ecnB entericidin B membrane lipoprotein b4411 9 COG5510 COG5510, Predicted small secreted protein Function unknown 157783150 Nonpathogen uof ryhB-regulated fur leader peptide b4637 1 None None None 16132201 Common deoD purine-nucleoside phosphorylase b4384 95 COG0813 DeoD, Purine-nucleoside phosphorylase Nucleotide transport and metabolism 16129719 Common ydjA predicted oxidoreductase b1765 82 COG0778 NfnB, Nitroreductase Energy production and conversion 16131552 Common yidP predicted DNA-binding transcriptional regulator b3684 125 COG2188 PhnF, Transcriptional regulators Transcription 16131189 Common rplN 50S ribosomal subunit protein L14 b3310 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 16132114 Common fecI KpLE2 phage-like element; RNA polymerase, sigma 19 factor b4293 98 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 16128873 Common ycaP conserved inner membrane protein b0906 69 COG2323 COG2323, Predicted membrane protein Function unknown 16128652 Common nagC DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine b0676 169 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 16128134 Common yadN predicted fimbrial-like adhesin protein b0141 13 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16128322 Common codA cytosine deaminase b0337 71 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 16129458 Common ydeO predicted DNA-binding transcriptional acfivator b1499 25 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16128767 Common dinG ATP-dependent DNA helicase b0799 126 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 16131535 Common ade cryptic adenine deaminase b3665 70 COG1001 AdeC, Adenine deaminase Nucleotide transport and metabolism 16128138 Common dksA DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein b0145 119 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 90111606 Common kdgK ketodeoxygluconokinase b3526 149 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 16130171 Common yfaE predicted 2Fe-2S cluster-containing protein b2236 50 COG0633 Fdx, Ferredoxin Energy production and conversion 16129896 Common fliQ flagellar biosynthesis protein b1949 70 COG1987 FliQ, Flagellar biosynthesis pathway, component FliQ Cell motility and secretion / Intracellular trafficking and secretion 16129944 Common yeeT CP4-44 prophage; predicted protein b2003 4 None None None 16132061 Common treC trehalose-6-P hydrolase b4239 166 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 16128537 Common essD DLP12 prophage; predicted phage lysis protein b0554 5 None None None 16130525 Common yfiN predicted diguanylate cyclase b2604 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 16128040 Common kefF flavoprotein subunit for the KefC potassium efflux system b0046 76 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 16131190 Common rpsQ 30S ribosomal subunit protein S17 b3311 237 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 162135912 Common hdeB acid-resistance protein b3509 5 None None None 16128490 Common allR DNA-binding transcriptional repressor b0506 122 COG1414 IclR, Transcriptional regulator Transcription 16131780 Common katG catalase/hydroperoxidase HPI(I) b3942 98 COG0376 KatG, Catalase (peroxidase I) Inorganic ion transport and metabolism 90111629 Common yicJ predicted transporter b3657 82 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 90111255 Common kilR Rac prophage; inhibitor of ftsZ, killing protein b1352 3 None None None 16131103 Common gltD glutamate synthase, 4Fe-4S protein, small subunit b3213 213 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 16129405 Common ydcY predicted protein b1446 6 None None None 16129604 Common sodC superoxide dismutase, Cu, Zn b1646 87 COG2032 SodC, Cu/Zn superoxide dismutase Inorganic ion transport and metabolism 16130763 Common insD KpLE2 phage-like element; IS2 insertion element transposase InsAB' b2860 92 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 90111588 Common yhgF predicted transcriptional accessory protein b3407 214 COG2183 Tex, Transcriptional accessory protein Transcription 16129899 Common dsrB predicted protein b1952 10 None None None 16131901 Common nrfF heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfF b4075 83 COG3088 CcmH, Uncharacterized protein involved in biosynthesis of c-type cytochromes Posttranslational modification, protein turnover, chaperones 16130090 Common yeiB conserved inner membrane protein b2152 48 COG2311 COG2311, Predicted membrane protein Function unknown 90111737 Common mcrB 5-methylcytosine-specific restriction enzyme McrBC, subunit McrB b4346 55 COG1401 McrB, GTPase subunit of restriction endonuclease Defense mechanisms 16129378 Common ydcA predicted protein b1419 5 None None None 16129491 Common marB predicted protein b1532 6 None None None 16130464 Common hcaF 3-phenylpropionate dioxygenase, small (beta) subunit b2539 24 COG5517 COG5517, Small subunit of phenylpropionate dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 16128277 Common matC predicted protein b0292 6 None None None 16128232 Common ykfG CP4-6 prophage; predicted DNA repair protein b0247 176 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 145698276 Common cedA cell division modulator b1731 6 None None None 90111645 Common atpI ATP synthase, membrane-bound accesory subunit b3739 13 COG3312 AtpI, F0F1-type ATP synthase, subunit I Energy production and conversion 16131490 Common rfaD ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding b3619 225 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 16130871 Common yghG predicted protein b2971 1 None None None 16129905 Common yedA predicted inner membrane protein b1959 50 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 16129937 Common insD KpLE2 phage-like element; IS2 insertion element transposase InsAB' b1996 92 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 16128822 Common potF putrescine transporter subunit: periplasmic-binding component of ABC superfamily b0854 132 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 16131983 Common yjeO conserved inner membrane protein b4158 4 None None None 16128554 Common cusR DNA-binding response regulator in two-component regulatory system with CusS b0571 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 16129752 Common leuE neutral amino-acid efflux system b1798 127 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 16130699 Common yqcC conserved protein b2792 29 COG3098 COG3098, Uncharacterized protein conserved in bacteria Function unknown 16130966 Common yqjI predicted transcriptional regulator b3071 70 COG1695 COG1695, Predicted transcriptional regulators Transcription 16129614 Common sodB superoxide dismutase, Fe b1656 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 162135920 Common tynA tyramine oxidase, copper-requiring b1386 24 COG3733 TynA, Cu2+-containing amine oxidase Secondary metabolites biosynthesis, transport, and catabolism 16128752 Common moaD molybdopterin synthase, small subunit b0784 78 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 16128146 Common fhuB fused iron-hydroxamate transporter subunits of ABC superfamily: membrane components b0153 191 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 16129425 Common narW nitrate reductase 2 (NRZ), delta subunit (assembly subunit) b1466 39 COG2180 NarJ, Nitrate reductase delta subunit Energy production and conversion 16128524 Common insF IS3 element protein InsF b0541 149 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 16131023 Common agaR DNA-binding transcriptional dual regulator b3131 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 16130986 Common uxaA altronate hydrolase b3091 73 COG2721 UxaA, Altronate dehydratase Carbohydrate transport and metabolism 90111334 Common yeaP predicted diguanylate cyclase b1794 176 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 16131941 Common adiC arginine:agmatin b4115 180 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 16129339 Common ydbK fused predicted pyruvate-flavodoxin oxidoreductase: conserved protein/conserved protein/FeS binding protein b1378 118 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 16129973 Common wbbJ predicted acyl transferase b2033 24 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 16130583 Common stpA DNA binding protein, nucleoid-associated b2669 32 COG2916 Hns, DNA-binding protein H-NS General function prediction only 16128428 Common ybaW conserved protein b0443 22 COG0824 FcbC, Predicted thioesterase General function prediction only 16130278 Common yfdF predicted protein b2345 2 None None None 90111640 Common cbrA predicted oxidoreductase with FAD/NAD(P)-binding domain b3690 39 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 90111684 Common yjcS predicted alkyl sulfatase b4083 44 COG2015 COG2015, Alkyl sulfatase and related hydrolases Secondary metabolites biosynthesis, transport, and catabolism 16131572 Common rnpA protein C5 component of RNase P b3704 73 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 16129139 Common minC cell division inhibitor b1176 79 COG0850 MinC, Septum formation inhibitor Cell division and chromosome partitioning 16130702 Common ygdH conserved protein b2795 48 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 16129158 Common ymgE predicted inner membrane protein b1195 51 COG2261 COG2261, Predicted membrane protein Function unknown 49176107 Common hokB toxic polypeptide, small b4428 1 None None None 16131227 Common slyX conserved protein b3348 21 COG2900 SlyX, Uncharacterized protein conserved in bacteria Function unknown 16128548 Common ompT DLP12 prophage; outer membrane protease VII (outer membrane protein 3b) b0565 12 COG4571 OmpT, Outer membrane protease Cell envelope biogenesis, outer membrane 16130099 Common nupX predicted nucleoside transporter b2161 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 16128532 Common ybcO DLP12 prophage; predicted protein b0549 7 None None None 16128100 Common hofB conserved protein with nucleoside triphosphate hydrolase domain b0107 225 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 16132135 Common fimA major type 1 subunit fimbrin (pilin) b4314 21 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 90111694 Common poxA predicted lysyl-tRNA synthetase b4155 221 COG2269 COG2269, Truncated, possibly inactive, lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 16127998 Common thrC threonine synthase b0004 163 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 16131501 Common rfaP kinase that phosphorylates core heptose of lipopolysaccharide b3630 10 None None None 16131599 Common atpC F1 sector of membrane-bound ATP synthase, epsilon subunit b3731 179 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 16130817 Common argP DNA-binding transcriptional activator, replication initiation inhibitor b2916 79 COG0583 LysR, Transcriptional regulator Transcription 16131387 Common gadW DNA-binding transcriptional activator b3515 43 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 90111291 Common eamA cysteine and O-acetyl-L-serine efflux system b1533 176 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 16128511 Common ybcI conserved inner membrane protein b0527 11 COG1988 COG1988, Predicted membrane-bound metal-dependent hydrolases General function prediction only 16128219 Common yafO predicted toxin of the YafO-YafN toxin-antitoxin system b0233 6 None None None 16130493 Common lepB leader peptidase (signal peptidase I) b2568 203 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 16128175 Common lpxB tetraacyldisaccharide-1-P synthase b0182 139 COG0763 LpxB, Lipid A disaccharide synthetase Cell envelope biogenesis, outer membrane 16128815 Common ybjL predicted transporter b0847 57 COG2985 COG2985, Predicted permease General function prediction only 16130991 Common yqjB conserved protein b3096 9 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 16131871 Common yjbJ predicted stress response protein b4045 56 COG3237 COG3237, Uncharacterized protein conserved in bacteria Function unknown 16129589 Common rsxG predicted oxidoreductase b1631 58 COG4659 RnfG, Predicted NADH:ubiquinone oxidoreductase, subunit RnfG Energy production and conversion 16130292 Common yfdQ CPS-53 (KpLE1) prophage; predicted protein b2360 6 COG5532 COG5532, Uncharacterized conserved protein Function unknown 16130419 Common yfgC predicted peptidase b2494 126 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 16128210 Common yafK conserved protein b0224 53 COG3034 COG3034, Uncharacterized protein conserved in bacteria Function unknown 16128629 Common djlB predicted chaperone b0646 7 None None None 16131348 Common nikA nickel transporter subunit b3476 211 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 90111548 Common yhbO predicted intracellular protease b3153 158 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 16130410 Common hyfE hydrogenase 4, membrane subunit b2485 34 COG4237 HyfE, Hydrogenase 4 membrane component (E) Energy production and conversion 16131351 Common nikD nickel transporter subunit b3479 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 16128981 Common putP proline:sodium symporter b1015 178 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 16131776 Common metJ DNA-binding transcriptional repressor, S-adenosylmethionine-binding b3938 23 COG3060 MetJ, Transcriptional regulator of met regulon Transcription / Amino acid transport and metabolism 16129631 Common ydhZ predicted protein b1675 6 None None None 16129702 Common astC succinylornithine transaminase, PLP-dependent b1748 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 90111561 Common yhcN conserved protein b3238 8 None None None 16128641 Common ybeX predicteed ion transport b0658 220 COG4535 CorC, Putative Mg2+ and Co2+ transporter CorC Inorganic ion transport and metabolism 16130867 Common yqgA predicted inner membrane protein b2966 47 COG1811 COG1811, Uncharacterized membrane protein, possible Na+ channel or pump General function prediction only 16130544 Common yfjJ CP4-57 prophage; predicted protein b2626 7 None None None 16131478 Common cysE serine acetyltransferase b3607 212 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 16128506 Common purK N5-carboxyaminoimidazole ribonucleotide synthase b0522 191 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 16132019 Common ulaE L-xylulose 5-phosphate 3-epimerase b4197 39 COG3623 SgaU, Putative L-xylulose-5-phosphate 3-epimerase Carbohydrate transport and metabolism 16130618 Common norW NADH:flavorubredoxin oxidoreductase b2711 240 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 16130857 Common yggM conserved protein b2956 3 None None None 16129539 Common rspA predicted dehydratase b1581 106 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 16131079 Common murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase b3189 220 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 16128735 Common pgl 6-phosphogluconolactonase b0767 52 COG2706 COG2706, 3-carboxymuconate cyclase Carbohydrate transport and metabolism 16131267 Common aroB 3-dehydroquinate synthase b3389 205 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 145698247 Common chaC regulatory protein for cation transport b1218 44 COG3703 ChaC, Uncharacterized protein involved in cation transport Inorganic ion transport and metabolism 16128018 Common yaaY predicted protein b0024 3 None None None 16128518 Common sfmF predicted fimbrial-like adhesin protein b0534 21 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16128417 Common cyoA cytochrome o ubiquinol oxidase subunit II b0432 140 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 16130114 Common rtn conserved protein b2176 163 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 16129434 Common fdnH formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible b1475 160 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 16130381 Common eutN predicted carboxysome structural protein, ethanolamine utilization protein b2456 43 COG4576 CcmL, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 16128262 Common yagK CP4-6 prophage; conserved protein b0277 7 None None None 16128602 Common dpiB sensory histidine kinase in two-component regulatory system with citB b0619 191 COG3290 CitA, Signal transduction histidine kinase regulating citrate/malate metabolism Signal transduction mechanisms 16131318 Common yrhB predicted protein b3446 2 None None None 16129242 Common pyrF orotidine-5'-phosphate decarboxylase b1281 169 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 16130362 Common eutR predicted DNA-binding transcriptional regulator b2437 58 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16131199 Common rplC 50S ribosomal subunit protein L3 b3320 231 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 16131767 Common rraA ribonuclease E (RNase E) inhibitor protein b3929 67 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 16128740 Common ybhC predicted pectinesterase b0772 17 COG4677 PemB, Pectin methylesterase Carbohydrate transport and metabolism 16131601 Common atpG F1 sector of membrane-bound ATP synthase, gamma subunit b3733 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 16128869 Common pflA pyruvate formate lyase activating enzyme 1 b0902 108 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 162135906 Common yfdE predicted CoA-transferase, NAD(P)-binding b2371 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 90111508 Common ygfS predicted oxidoreductase, 4Fe-4S ferredoxin-type subunit b2886 159 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 90111730 Common yjiD DNA replication/recombination/repair protein b4326 3 COG3518 COG3518, Uncharacterized protein conserved in bacteria Function unknown 16131590 Common bglF fused beta-glucoside-specific PTS enzymes: IIA component/IIB component/IIC component b3722 60 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 16128194 Common dkgB 2,5-diketo-D-gluconate reductase B b0207 186 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 16129804 Common edd 6-phosphogluconate dehydratase b1851 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 16129849 Common otsB trehalose-6-phosphate phosphatase, biosynthetic b1897 90 COG1877 OtsB, Trehalose-6-phosphatase Carbohydrate transport and metabolism 90111267 Common ynbA predicted inner membrane protein b1408 23 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 16129276 Common ycjS predicted oxidoreductase, NADH-binding b1315 188 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 16129462 Common ydeR predicted fimbrial-like adhesin protein b1503 13 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 49176076 Common flgI predicted flagellar basal body protein b1080 104 COG1706 FlgI, Flagellar basal-body P-ring protein Cell motility and secretion 162135919 Common dinF DNA-damage-inducible SOS response protein b4044 94 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 16130896 Common hybA hydrogenase 2 4Fe-4S ferredoxin-type component b2996 163 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 16129522 Common relE Qin prophage; toxin of the RelE-RelB toxin-antitoxin system b1563 30 COG2026 RelE, Cytotoxic translational repressor of toxin-antitoxin stability system Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning 16128952 Common gfcB predicted outer membrane lipoprotein b0986 13 None None None 16129588 Common rsxD predicted inner membrane oxidoreductase b1630 76 COG4658 RnfD, Predicted NADH:ubiquinone oxidoreductase, subunit RnfD Energy production and conversion 90111166 Common cydA cytochrome d terminal oxidase, subunit I b0733 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 49176497 Common yjjM predicted DNA-binding transcriptional regulator b4357 47 COG1802 GntR, Transcriptional regulators Transcription 16131789 Common pflD predicted formate acetyltransferase 2 (pyruvate formate lyase II) b3951 59 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 16128694 Common ybgD predicted fimbrial-like adhesin protein b0719 17 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16131656 Common hemD uroporphyrinogen III synthase b3804 57 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 16128024 Common rihC ribonucleoside hydrolase 3 b0030 87 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 90111402 Common ccmA heme exporter subunit b2201 236 COG4133 CcmA, ABC-type transport system involved in cytochrome c biogenesis, ATPase component Posttranslational modification, protein turnover, chaperones 16128796 Common iaaA L-asparaginase b0828 84 COG1446 COG1446, Asparaginase Amino acid transport and metabolism 16129263 Common puuE GABA aminotransferase, PLP-dependent b1302 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 16131742 Common rhaD rhamnulose-1-phosphate aldolase b3902 22 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 145698311 Common ygjR predicted NAD(P)-binding dehydrogenase b3087 129 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 49176311 Common alx predicted inner membrane protein, part of terminus b3088 103 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 16132203 Common lplA lipoate-protein ligase A b4386 74 COG0095 LplA, Lipoate-protein ligase A Coenzyme metabolism 16130923 Common ygiZ conserved inner membrane protein b3027 3 None None None 16131473 Common yibL conserved protein b3602 13 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 16130016 Common mdtC multidrug efflux system, subunit C b2076 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 16129592 Common tppB predicted transporter b1634 86 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 16129629 Common ydhV predicted oxidoreductase b1673 57 COG2414 COG2414, Aldehyde:ferredoxin oxidoreductase Energy production and conversion 16129653 Common ydiQ conserved protein b1697 151 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 16130438 Common yfgM conserved protein b2513 60 COG2976 COG2976, Uncharacterized protein conserved in bacteria Function unknown 16130552 Common yfjR CP4-57 prophage; predicted DNA-binding transcriptional regulator b2634 8 COG2378 COG2378, Predicted transcriptional regulator Transcription 16131843 Common arpA ankyrin repeat protein, function unknown b4017 5 None None None 90111429 Common yfeC predicted DNA-binding transcriptional regulator b2398 6 None None None 49176336 Common smf conserved protein b4473 209 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 16129792 Common yebY predicted protein b1839 11 None None None 16128807 Common dacC D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 6a) b0839 153 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 90111716 Common yjgB predicted alcohol dehydrogenase, Zn-dependent and NAD(P)-binding b4269 189 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 90111197 Common yccK predicted sulfite reductase subunit b0969 60 COG2920 DsrC, Dissimilatory sulfite reductase (desulfoviridin), gamma subunit Inorganic ion transport and metabolism 16131302 Common glgP glycogen phosphorylase b3428 146 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 90111310 Common slyA DNA-binding transcriptional activator b1642 119 COG1846 MarR, Transcriptional regulators Transcription 90111420 Common yfcO predicted protein b2332 3 None None None 16128673 Common kdpB potassium translocating ATPase, subunit B b0697 232 COG2216 KdpB, High-affinity K+ transport system, ATPase chain B Inorganic ion transport and metabolism 16129303 Common ydaN predicted Zn(II) transporter b1342 98 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 16130390 Common tktB transketolase 2, thiamin-binding b2465 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 16129395 Common yncJ predicted protein b1436 4 None None None 16130281 Common intS CPS-53 (KpLE1) prophage; predicted prophage CPS-53 integrase b2349 108 COG0582 XerC, Integrase DNA replication, recombination, and repair 49176358 Common livJ leucine/isoleucine/valine transporter subunit b3460 140 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 90111242 Common yciW predicted oxidoreductase b1287 10 COG4950 COG4950, Uncharacterized protein conserved in bacteria Function unknown 90111660 Common yihW predicted DNA-binding transcriptional regulator b3884 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 16128686 Common ybgJ predicted enzyme subunit b0711 101 COG2049 DUR1, Allophanate hydrolase subunit 1 Amino acid transport and metabolism 16131951 Common dcuS sensory histidine kinase in two-component regulatory system with DcuR, regulator of anaerobic fumarate respiration b4125 205 COG3290 CitA, Signal transduction histidine kinase regulating citrate/malate metabolism Signal transduction mechanisms 16131414 Common dppC dipeptide transporter b3542 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 16131948 Common fumB anaerobic class I fumarate hydratase (fumarase B) b4122 146 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 16129564 Common folM dihydrofolate reductase isozyme b1606 133 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 16132090 Common idnK D-gluconate kinase, thermosensitive b4268 80 COG3265 GntK, Gluconate kinase Carbohydrate transport and metabolism 16131639 Common rho transcription termination factor b3783 201 COG1158 Rho, Transcription termination factor Transcription 16131704 Common polA fused DNA polymerase I 5'->3' exonuclease/3'->5' polymerase/3'->5' exonuclease b3863 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 90111345 Common yebA predicted peptidase b1856 188 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 16132099 Common insG KpLE2 phage-like element; IS4 predicted transposase b4278 24 COG3385 COG3385, FOG: Transposase and inactivated derivatives DNA replication, recombination, and repair 49176138 Common pfkB 6-phosphofructokinase II b1723 145 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 16128835 Common ybjR predicted amidase and lipoprotein b0867 106 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 16131521 Common spoT bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase b3650 207 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 16129123 Common elbA predicted protein b1160 5 None None None 16130504 Common yfiD pyruvate formate lyase subunit b2579 52 COG3445 COG3445, Acid-induced glycyl radical enzyme General function prediction only 16129268 Common pspD peripheral inner membrane phage-shock protein b1307 8 None None None 16128074 Common mraZ conserved protein b0081 143 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 16131030 Common agaB N-acetylgalactosamine-specific enzyme IIB component of PTS b3138 38 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 16129643 Common ydiJ predicted FAD-linked oxidoreductase b1687 202 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 16131367 Common uspA universal stress global response regulator b3495 37 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 16128058 Common araC DNA-binding transcriptional dual regulator b0064 128 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16128097 Common guaC GMP reductase b0104 233 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 90111139 Common ylaC predicted inner membrane protein b0458 10 None None None 90111503 Common ygeR tetratricopeptide repeat transcriptional regulator b2865 192 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 16130997 Common yqjG predicted S-transferase b3102 79 COG0435 ECM4, Predicted glutathione S-transferase Posttranslational modification, protein turnover, chaperones 16131094 Common ptsN sugar-specific enzyme IIA component of PTS b3204 133 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 16131039 Common yraM conserved protein b3147 40 COG3107 LppC, Putative lipoprotein General function prediction only 90111701 Common yjfO conserved protein b4189 9 None None None 49176308 Common ebgA cryptic beta-D-galactosidase, alpha subunit b3076 72 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 16129721 Common ansA cytoplasmic L-asparaginase I b1767 139 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 16129233 Common sohB predicted inner membrane peptidase b1272 189 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 16131232 Common yheT predicted hydrolase b3353 70 COG0429 COG0429, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 145698343 Common ytfT predicted sugar transporter subunit: membrane component of ABC superfamily b4230 114 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 145698220 Nonpathogen ykfM hypothetical protein, no homologs b4586 1 None None None 16128341 Common frmA alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase b0356 198 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 16129870 Common fliC flagellar filament structural protein (flagellin) b1923 115 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 16131581 Common yieF chromate reductase, Class I, flavoprotein b3713 114 COG0431 COG0431, Predicted flavoprotein General function prediction only 90111464 Common pssA phosphatidylserine synthase (CDP-diacylglycerol-serine O-phosphatidyltransferase) b2585 30 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 90111568 Common yrdA conserved protein b3279 190 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 16132022 Common rpsF 30S ribosomal subunit protein S6 b4200 188 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 16128747 Common uvrB excinulease of nucleotide excision repair, DNA damage recognition component b0779 230 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 49176398 Common viaA predicted von Willibrand factor containing protein b3745 28 COG2425 COG2425, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 16131896 Common nrfA nitrite reductase, formate-dependent, cytochrome b4070 40 COG3303 NrfA, Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit Inorganic ion transport and metabolism 90111190 Common ycbQ predicted fimbrial-like adhesin protein b0938 21 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16130239 Common yfcH conserved protein with NAD(P)-binding Rossmann-fold domain b2304 129 COG1090 COG1090, Predicted nucleoside-diphosphate sugar epimerase General function prediction only 16132047 Common chpB toxin of the ChpB-ChpS toxin-antitoxin system b4225 32 COG2337 MazF, Growth inhibitor Signal transduction mechanisms 90111515 Common rsmE predicted protein b2946 193 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 16129671 Nonpathogen pheM phenylalanyl-tRNA synthetase operon leader peptide b1715 1 None None None 16129739 Common yeaI predicted diguanylate cyclase b1785 175 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 16129595 Common tyrS tyrosyl-tRNA synthetase b1637 216 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 16128244 Common insH IS5 transposase and trans-activator b0259 37 COG3039 COG3039, Transposase and inactivated derivatives, IS5 family DNA replication, recombination, and repair 16128002 Common talB transaldolase B b0008 185 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 16130422 Common uraA uracil transporter b2497 127 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 90111097 Common rof modulator of Rho-dependent transcription termination b0189 13 COG4568 Rof, Transcriptional antiterminator Transcription 16130627 Common hycF formate hydrogenlyase complex iron-sulfur protein b2720 194 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 16129766 Common pabB aminodeoxychorismate synthase, subunit I b1812 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 16128499 Common ylbA conserved protein b0515 33 COG3257 GlxB, Uncharacterized protein, possibly involved in glyoxylate utilization General function prediction only 16131618 Common rbsC D-ribose transporter subunit b3750 140 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 16130918 Common mqsR predicted cyanide hydratase b3022 13 None None None 16131125 Common degS serine endoprotease, periplasmic b3235 221 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 16128569 Common entF enterobactin synthase multienzyme complex component, ATP-dependent b0586 217 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 16130974 Common ygjJ conserved protein b3079 4 None None None 16129512 Common ydfP Qin prophage; conserved protein b1553 6 None None None 16129732 Common msrB methionine sulfoxide reductase B b1778 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 90111650 Common dapF diaminopimelate epimerase b3809 202 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 16128113 Common speD S-adenosylmethionine decarboxylase b0120 30 COG1586 SpeD, S-adenosylmethionine decarboxylase Amino acid transport and metabolism 16128382 Common sbcC exonuclease, dsDNA, ATP-dependent b0397 111 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 16128993 Common ycdU predicted inner membrane protein b1029 2 None None None 16129475 Common lsrB AI2 transporter b1516 52 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 16129624 Common ydhS conserved protein with FAD/NAD(P)-binding domain b1668 13 COG4529 COG4529, Uncharacterized protein conserved in bacteria Function unknown 16130039 Common yegW predicted DNA-binding transcriptional regulator b2101 126 COG2188 PhnF, Transcriptional regulators Transcription 16129728 Common ydjJ predicted oxidoreductase, Zn-dependent and NAD(P)-binding b1774 214 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 16128305 Common yahF predicted acyl-CoA synthetase with NAD(P)-binding domain and succinyl-CoA synthetase domain b0320 167 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 90111705 Common fklB FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) b4207 146 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 90111388 Common mrp antiporter inner membrane protein b2113 229 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 16128714 Common tolA membrane anchored protein in TolA-TolQ-TolR complex b0739 18 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 16129488 Common marC predicted transporter b1529 159 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 16129823 Common cmoA predicted methyltransferase b1870 54 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 16129678 Common ydiZ predicted protein b1724 7 None None None 16132008 Common yjfC predicted synthetase/amidase b4186 53 COG0754 Gsp, Glutathionylspermidine synthase Amino acid transport and metabolism 16129444 Common ddpC D-ala-D-ala transporter subunit b1485 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 49176012 Common lacI DNA-binding transcriptional repressor b0345 128 COG1609 PurR, Transcriptional regulators Transcription 16129033 Common flgN export chaperone for FlgK and FlgL b1070 12 COG3418 COG3418, Flagellar biosynthesis/type III secretory pathway chaperone Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 90111437 Common eutB ethanolamine ammonia-lyase, large subunit, heavy chain b2441 55 COG4303 EutB, Ethanolamine ammonia-lyase, large subunit Amino acid transport and metabolism 16130451 Common hscA DnaK-like molecular chaperone specific for IscU b2526 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 16129289 Common ycjZ predicted DNA-binding transcriptional regulator b1328 133 COG0583 LysR, Transcriptional regulator Transcription 16130727 Common ppdC predicted protein b2823 6 COG4967 PilV, Tfp pilus assembly protein PilV Cell motility and secretion / Intracellular trafficking and secretion 90111093 Common cdaR DNA-binding transcriptional activator b0162 49 COG3835 CdaR, Sugar diacid utilization regulator Transcription / Signal transduction mechanisms 16128353 Common tauD taurine dioxygenase, 2-oxoglutarate-dependent b0368 47 COG2175 TauD, Probable taurine catabolism dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 16131999 Common purA adenylosuccinate synthetase b4177 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 16131839 Common metA homoserine O-transsuccinylase b4013 64 COG1897 MetA, Homoserine trans-succinylase Amino acid transport and metabolism 16129287 Common mpaA murein peptide amidase A b1326 18 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 90111414 Common yfbT predicted hydrolase or phosphatase b2293 147 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 16131493 Common rfaL O-antigen ligase b3622 6 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 16131151 Common yhdU predicted membrane protein b3263 5 None None None 90111180 Common hcp hybrid-cluster [4Fe-2S-2O] protein in anaerobic terminal reductases b0873 75 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 16128102 Common nadC quinolinate phosphoribosyltransferase b0109 204 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 16130630 Common hycC hydrogenase 3, membrane subunit b2723 206 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 145698231 Common ybfK hypothetical protein b4590 3 None None None 16130746 Common kduD 2-deoxy-D-gluconate 3-dehydrogenase b2842 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 16129542 Common speG spermidine N1-acetyltransferase b1584 100 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 49176279 Common ygfQ predicted transporter b4464 134 COG2252 COG2252, Permeases General function prediction only 16131836 Common purH fused IMP cyclohydrolase/phosphoribosylaminoimidazolecarboxamide formyltransferase b4006 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 16128214 Common yafM conserved protein b0228 33 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 16131804 Common btuB vitamin B12/cobalamin outer membrane transporter b3966 128 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 16128783 Common ybiP predicted hydrolase, inner membrane b0815 47 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 94541102 Common ybgT conserved protein b4515 15 COG4890 COG4890, Predicted outer membrane lipoprotein Function unknown 16128171 Common skp periplasmic chaperone b0178 55 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 90111377 Common wzc protein-tyrosine kinase b2060 146 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 16130210 Nonpathogen yfbP predicted protein b2275 1 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 16130306 Common frc formyl-CoA transferase, NAD(P)-binding b2374 115 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 16130149 Common alkB oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions b2212 57 COG3145 AlkB, Alkylated DNA repair protein DNA replication, recombination, and repair 16130594 Common ygaZ predicted transporter b2682 104 COG1296 AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) Amino acid transport and metabolism 145698233 Common ybhD predicted DNA-binding transcriptional regulator b0768 191 COG0583 LysR, Transcriptional regulator Transcription 16128743 Common bioB biotin synthase b0775 183 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 16128020 Common ileS isoleucyl-tRNA synthetase b0026 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 16128831 Common artI arginine transporter subunit b0863 181 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 16128461 Common gsk inosine/guanosine kinase b0477 56 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 49176403 Common ilvE branched-chain amino-acid aminotransferase b3770 220 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 16130937 Common ribB 3,4-dihydroxy-2-butanone-4-phosphate synthase b3041 228 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 90111399 Common yeiP predicted elongtion factor b2171 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 90111554 Common greA transcription elongation factor b3181 204 COG0782 GreA, Transcription elongation factor Transcription 16129101 Common ymfE e14 prophage; predicted inner membrane protein b1138 2 None None None 16131063 Common argG argininosuccinate synthetase b3172 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 16129204 Common oppA oligopeptide transporter subunit b1243 208 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 16128178 Common accA acetyl-CoA carboxylase, carboxytransferase, alpha subunit b0185 191 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 16128481 Common rhsD rhsD element protein b0497 70 COG3209 RhsA, Rhs family protein Cell envelope biogenesis, outer membrane 16129586 Common rsxB predicted iron-sulfur protein b1628 122 COG2878 COG2878, Predicted NADH:ubiquinone oxidoreductase, subunit RnfB Energy production and conversion 16129935 Common insH IS5 transposase and trans-activator b1994 37 COG3039 COG3039, Transposase and inactivated derivatives, IS5 family DNA replication, recombination, and repair 16128991 Common insE IS3 element protein InsE b1027 32 None None None 16131327 Common livG leucine/isoleucine/valine transporter subunit b3455 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 16129816 Common ruvC component of RuvABC resolvasome, endonuclease b1863 195 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 16129736 Common mipA scaffolding protein for murein synthesizing machinery b1782 35 COG3713 OmpV, Outer membrane protein V Cell envelope biogenesis, outer membrane 90111189 Common ssuA alkanesulfonate transporter subunit b0936 104 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 16130332 Common xapB xanthosine transporter b2406 25 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 16131854 Common yjbG conserved protein b4028 15 None None None 16132012 Common yjfP predicted hydrolase b4190 20 COG1073 COG1073, Hydrolases of the alpha/beta superfamily General function prediction only 16128109 Common lpd lipoamide dehydrogenase, E3 component is part of three enzyme complexes b0116 245 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 16129069 Common thiK thiamin kinase b1106 15 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 90111409 Common yfbJ predicted inner membrane protein b2258 6 None None None 16131110 Common yhcG conserved protein b3220 49 COG4804 COG4804, Uncharacterized conserved protein Function unknown 16130771 Common ygeV predicted DNA-binding transcriptional regulator b2869 172 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 90111221 Common ymfJ e14 prophage; predicted protein b1144 3 None None None 16128610 Common tatE TatABCE protein translocation system subunit b0627 6 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 16130461 Common hcaT predicted 3-phenylpropionic transporter b2536 75 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16130002 Common wza lipoprotein required for capsular polysaccharide translocation through the outer membrane b2062 124 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 16130542 Common alpA CP4-57 prophage; DNA-binding transcriptional activator b2624 33 COG3311 AlpA, Predicted transcriptional regulator Transcription 16129227 Common trpH conserved protein b1266 115 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 16128358 Common insE IS3 element protein InsE b0373 32 None None None 16131343 Common yhhQ conserved inner membrane protein b3471 83 COG1738 COG1738, Uncharacterized conserved protein Function unknown 145698317 Common yhbC conserved protein b3170 181 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 16132219 Common yjjY predicted protein b4402 4 None None None 16131911 Common alsE allulose-6-phosphate 3-epimerase b4085 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 16132190 Common holD DNA polymerase III, psi subunit b4372 19 COG3050 HolD, DNA polymerase III, psi subunit DNA replication, recombination, and repair 16130713 Common ygdE predicted methyltransferase b2806 45 COG2933 COG2933, Predicted SAM-dependent methyltransferase General function prediction only 16128295 Common ykgH predicted inner membrane protein b0310 3 None None None 145698294 Common yfeD predicted DNA-binding transcriptional regulator b2399 6 None None None 16130354 Common murP fused predicted PTS enzymes: IIB component/IIC component b2429 47 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 90111675 Common iclR DNA-binding transcriptional repressor b4018 124 COG1414 IclR, Transcriptional regulator Transcription 16131977 Common frdC fumarate reductase (anaerobic), membrane anchor subunit b4152 23 COG3029 FrdC, Fumarate reductase subunit C Energy production and conversion 16129772 Common manY mannose-specific enzyme IIC component of PTS b1818 37 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 16130388 Common maeB fused malic enzyme predicted oxidoreductase/predicted phosphotransacetylase b2463 216 COG0281 SfcA, Malic enzyme Energy production and conversion 16131313 Common yhhY predicted acetyltransferase b3441 73 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 90111631 Common yicO predicted xanthine/uracil permase b3664 139 COG2252 COG2252, Permeases General function prediction only 16128921 Common fabA beta-hydroxydecanoyl thioester dehydrase b0954 81 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 49176118 Common lsrK autoinducer-2 (AI-2) kinase b1511 177 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 16131636 Common rhlB ATP-dependent RNA helicase b3780 235 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 16130798 Common ygfX predicted protein b2896 11 None None None 90111492 Common amiC N-acetylmuramoyl-L-alanine amidase b2817 177 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 145698224 Common insC KpLE2 phage-like element; IS2 insertion element repressor InsA b0360 39 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 90111264 Common feaB phenylacetaldehyde dehydrogenase b1385 221 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 145698306 Common insC KpLE2 phage-like element; IS2 insertion element repressor InsA b2861 39 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 16130342 Common ptsI PEP-protein phosphotransferase of PTS system (enzyme I) b2416 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 16131820 Common thiH thiamin biosynthesis ThiGH complex subunit b3990 56 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 16130295 Common yfdT CPS-53 (KpLE1) prophage; predicted protein b2363 2 None None None 16130884 Common yghR predicted protein with nucleoside triphosphate hydrolase domain b2984 4 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 16129151 Common ycgB conserved protein b1188 71 COG2719 SpoVR, Uncharacterized conserved protein Function unknown 16131933 Common yjdN conserved protein b4107 65 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 16131892 Common yjcF conserved protein b4066 39 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 90111212 Common plsX fatty acid/phospholipid synthesis protein b1090 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 16129174 Common prfA peptide chain release factor RF-1 b1211 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 49176270 Common xni exonuclease IX (5'-3' exonuclease) b2798 216 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 16128407 Common xseB exonuclease VII small subunit b0422 141 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 90111638 Common yidQ conserved outer membrane protein b3688 11 COG5645 COG5645, Predicted periplasmic lipoprotein General function prediction only 49176421 Common rhtC threonine efflux system b3823 105 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 16129093 Common phoP DNA-binding response regulator in two-component regulatory system with PhoQ b1130 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 16132006 Common yjfL conserved inner membrane protein b4184 29 COG3766 COG3766, Predicted membrane protein Function unknown 16129453 Common pqqL predicted peptidase b1494 200 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 16131043 Common yraQ predicted permease b3151 70 COG0701 COG0701, Predicted permeases General function prediction only 16131257 Common php predicted hydrolase b3379 35 COG1735 Php, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 16130207 Common yfbM predicted protein b2272 7 None None None 16129387 Common ydcK predicted enzyme b1428 8 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 16129663 Common ydiV conserved protein b1707 8 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 16131338 Common yhhL conserved inner membrane protein b3466 15 COG3776 COG3776, Predicted membrane protein Function unknown 90111372 Common yefM antitoxin of the YoeB-YefM toxin-antitoxin system b2017 52 COG2161 StbD, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 90111121 Common yaiS conserved protein b0364 55 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 16130720 Common mltA membrane-bound lytic murein transglycosylase A b2813 93 COG2821 MltA, Membrane-bound lytic murein transglycosylase Cell envelope biogenesis, outer membrane 16131241 Common yhfG predicted protein b3362 6 None None None 16131756 Common cdh CDP-diacylglycerol phosphotidylhydrolase b3918 18 COG2134 Cdh, CDP-diacylglycerol pyrophosphatase Lipid metabolism 16130708 Common fucP L-fucose transporter b2801 47 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 16129061 Common tmk thymidylate kinase b1098 228 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 90111725 Common yjhH KpLE2 phage-like element; predicted lyase/synthase b4298 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 16128781 Common rhtA threonine and homoserine efflux system b0813 76 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 16130606 Common recA DNA strand exchange and recombination protein with protease and nuclease activity b2699 223 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 16130834 Common cmtA predicted fused mannitol-specific PTS enzymes: IIB component/IIC component b2933 41 COG2213 MtlA, Phosphotransferase system, mannitol-specific IIBC component Carbohydrate transport and metabolism 16129118 Common ymfS e14 prophage; predicted protein b1155 6 None None None 16131648 Common wzxE O-antigen translocase b3792 24 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 90111714 Common yjgL predicted protein b4253 2 None None None 16130145 Common napF ferredoxin-type protein, predicted role in electron transfer to periplasmic nitrate reductase (NapA) b2208 57 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 90111595 Common dcrB periplasmic protein b3472 11 None None None 16130719 Common ygdL conserved protein b2812 218 COG1179 COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Coenzyme metabolism 90111642 Common yidB conserved protein b3698 31 COG3753 COG3753, Uncharacterized protein conserved in bacteria Function unknown 16130515 Common rluD 23S rRNA pseudouridine synthase b2594 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 16131906 Common mdtP predicted outer membrane factor of efflux pump b4080 112 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 16128290 Common ykgD predicted DNA-binding transcriptional regulator b0305 123 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16128979 Common rutR predicted DNA-binding transcriptional regulator b1013 64 COG1309 AcrR, Transcriptional regulator Transcription 16131377 Common insH IS5 transposase and trans-activator b3505 37 COG3039 COG3039, Transposase and inactivated derivatives, IS5 family DNA replication, recombination, and repair 16130118 Common yejF fused predicted oligopeptide transporter subunits of ABC superfamilly: ATP-binding components b2180 249 COG4172 COG4172, ABC-type uncharacterized transport system, duplicated ATPase component General function prediction only 16129779 Common yebO predicted protein b1825 8 None None None 16131585 Common cbrC conserved protein b3717 11 COG3196 COG3196, Uncharacterized protein conserved in bacteria Function unknown 16128310 Common yahK predicted oxidoreductase, Zn-dependent and NAD(P)-binding b0325 192 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 16128389 Common acpH conserved protein b0404 33 COG3124 COG3124, Uncharacterized protein conserved in bacteria Function unknown 16128062 Common tbpA thiamin transporter subunit b0068 54 COG4143 TbpA, ABC-type thiamine transport system, periplasmic component Coenzyme metabolism 16130111 Common yeiR predicted enzyme b2173 127 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 49176393 Common yidX predicted lipoproteinC b3696 5 None None None 16132112 Common fecA KpLE2 phage-like element; ferric citrate outer membrane transporter b4291 124 COG4772 FecA, Outer membrane receptor for Fe3+-dicitrate Inorganic ion transport and metabolism 90111439 Common eutM predicted carboxysome structural protein, ethanolamine utilization protein b2457 46 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 16131083 Common yrbD predicted ABC-type organic solvent transporter b3193 96 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 16130134 Common ccmE periplasmic heme chaperone b2197 92 COG2332 CcmE, Cytochrome c-type biogenesis protein CcmE Posttranslational modification, protein turnover, chaperones 16131524 Common gltS glutamate transporter b3653 53 COG0786 GltS, Na+/glutamate symporter Amino acid transport and metabolism 90111488 Common ygcS predicted transporter b2771 77 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16129024 Common dinI DNA damage-inducible protein I b1061 12 None None None 16128466 Common ybaP conserved protein b0482 41 COG3735 COG3735, Uncharacterized protein conserved in bacteria Function unknown 16128324 Common cynT carbonic anhydrase b0339 153 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 90111442 Common nlpB lipoprotein b2477 21 COG3317 NlpB, Uncharacterized lipoprotein Cell envelope biogenesis, outer membrane 49176363 Common rbbA fused ribosome-associated ATPase: ATP-binding protein/ATP-binding protein/predicted membrane protein b3486 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 16128760 Common ybhR predicted transporter subunit: membrane component of ABC superfamily b0792 183 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 16131447 Common yiaL conserved protein b3576 28 COG2731 EbgC, Beta-galactosidase, beta subunit Carbohydrate transport and metabolism 16131389 Common gadA glutamate decarboxylase A, PLP-dependent b3517 67 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 16130321 Common yfeO predicted ion channel protein b2389 10 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 16131174 Common rpoA RNA polymerase, alpha subunit b3295 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 16128181 Common tilS tRNA(Ile)-lysidine synthetase b0188 190 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 90111469 Common yfjF predicted protein b2618 68 COG2914 COG2914, Uncharacterized protein conserved in bacteria Function unknown 16131133 Common aaeR predicted DNA-binding transcriptional regulator, efflux system b3243 180 COG0583 LysR, Transcriptional regulator Transcription 16129356 Common paaH 3-hydroxybutyryl-CoA dehydrogenase b1395 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 16128969 Common yccJ predicted protein b1003 7 None None None 16128875 Common aroA 5-enolpyruvylshikimate-3-phosphate synthetase b0908 228 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 90111165 Common ybgQ predicted outer membrane protein b0718 30 COG3188 FimD, P pilus assembly protein, porin PapC Cell motility and secretion / Intracellular trafficking and secretion 16130256 Common flk predicted flagella assembly protein b2321 10 None None None 16132212 Common ytjC phosphoglyceromutase 2, co-factor independent b4395 172 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 16130807 Common gcvT aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex b2905 179 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 90111122 Common tauA taurine transporter subunit b0365 101 COG4521 TauA, ABC-type taurine transport system, periplasmic component Inorganic ion transport and metabolism 16129757 Common yeaX predicted oxidoreductase b1803 111 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 16128535 Common insH IS5 transposase and trans-activator b0552 37 COG3039 COG3039, Transposase and inactivated derivatives, IS5 family DNA replication, recombination, and repair 90111470 Nonpathogen yfjO CP4-57 prophage; predicted protein b2631 2 None None None 16128882 Common lpxK lipid A 4'kinase b0915 127 COG1663 LpxK, Tetraacyldisaccharide-1-P 4'-kinase Cell envelope biogenesis, outer membrane 16128459 Common hemH ferrochelatase b0475 159 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 16128769 Common ybiC predicted dehydrogenase b0801 67 COG2055 COG2055, Malate/L-lactate dehydrogenases Energy production and conversion 16128998 Common ycdY conserved protein b1035 20 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 90111251 Common abgT predicted cryptic aminobenzoyl-glutamate transporter b1336 40 COG2978 AbgT, Putative p-aminobenzoyl-glutamate transporter Coenzyme metabolism 16130756 Common ygeH predictedtranscriptional regulator b2852 8 COG3710 CadC, DNA-binding winged-HTH domains Transcription 16131097 Common yrbL predicted protein b3207 7 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 90111432 Common yfeW predicted periplasmic esterase b2430 141 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 16130052 Common metG methionyl-tRNA synthetase b2114 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 49176404 Common ilvD dihydroxyacid dehydratase b3771 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 145698349 Common bglJ DNA-binding transcriptional activator b4366 36 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 16130957 Common ttdA L-tartrate dehydratase, alpha subunit b3061 121 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 16128205 Common yafV predicted C-N hydrolase family amidase, NAD(P)-binding b0219 189 COG0388 COG0388, Predicted amidohydrolase General function prediction only 16129505 Common tfaQ Qin prophage; predicted tail fibre assembly protein b1546 15 COG5525 COG5525, Bacteriophage tail assembly protein General function prediction only 16128892 Common ycbB predicted carboxypeptidase b0925 74 COG2989 COG2989, Uncharacterized protein conserved in bacteria Function unknown 16129049 Common rluC 23S rRNA pseudouridylate synthase b1086 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 16131762 Common fpr ferredoxin-NADP reductase b3924 117 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 90111114 Common yahM predicted protein b0327 2 None None None 16129988 Common cpsG phosphomannomutase b2048 242 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 90111108 Common yagV conserved protein b0289 5 None None None 16128665 Common ybfP predicted protein b0689 2 None None None 90111449 Common yfgJ predicted protein b2510 9 None None None 16131394 Common yhjD conserved inner membrane protein b3522 50 COG1295 Rbn, Predicted membrane protein Function unknown 16132127 Common yjhP KpLE2 phage-like element; predicted methyltransferase b4306 35 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 16128654 Common nagB glucosamine-6-phosphate deaminase b0678 81 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 16130248 Common cvpA membrane protein required for colicin V production b2313 103 COG1286 CvpA, Uncharacterized membrane protein, required for colicin V production General function prediction only 16131329 Common livH leucine/isoleucine/valine transporter subunit b3457 151 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 16131548 Common yidJ predicted sulfatase/phosphatase b3678 93 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 16129403 Common ydcW medium chain aldehyde dehydrogenase b1444 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 16128565 Common insL IS186/IS421 transposase b0582 14 COG3385 COG3385, FOG: Transposase and inactivated derivatives DNA replication, recombination, and repair 90111320 Common ves conserved protein b1742 35 COG3758 COG3758, Uncharacterized protein conserved in bacteria Function unknown 16128198 Common mltD predicted membrane-bound lytic murein transglycosylase D b0211 152 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 49176409 Common rffE UDP-N-acetyl glucosamine-2-epimerase b3786 156 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 16131481 Common grxC glutaredoxin 3 b3610 132 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 16130682 Common yqcE predicted transporter b2775 20 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 16130645 Common ygbL predicted class II aldolase b2738 119 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 16128550 Common ybcH predicted protein b0567 3 None None None 49176285 Common yggP predicted dehydrogenase b4465 99 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 16130855 Common rdgB dITP/XTP pyrophosphatase b2954 237 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 90111088 Common hpt hypoxanthine phosphoribosyltransferase b0125 150 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 90111357 Common fliH flagellar biosynthesis protein b1940 46 COG1317 FliH, Flagellar biosynthesis/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 16130263 Common mepA murein DD-endopeptidase b2328 39 COG3770 MepA, Murein endopeptidase Cell envelope biogenesis, outer membrane 16128450 Common ybaM predicted protein b0466 15 None None None 16130939 Common ygiL predicted fimbrial-like adhesin protein b3043 16 COG3539 FimA, P pilus assembly protein, pilin FimA Cell motility and secretion / Intracellular trafficking and secretion 16128034 Common caiT predicted transporter b0040 96 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 16130527 Common rplS 50S ribosomal subunit protein L19 b2606 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 16130689 Common chpA toxin of the ChpA-ChpR toxin-antitoxin system, endoribonuclease b2782 50 COG2337 MazF, Growth inhibitor Signal transduction mechanisms 90111321 Common ydjX predicted inner membrane protein b1750 39 COG0398 COG0398, Uncharacterized conserved protein Function unknown 94541098 Common rzoD DLP12 prophage; predicted lipoprotein b4510 1 None None None 16129373 Common azoR NADH-azoreductase, FMN-dependent b1412 98 COG1182 AcpD, Acyl carrier protein phosphodiesterase Lipid metabolism 16129842 Common motA proton conductor component of flagella motor b1890 121 COG1291 MotA, Flagellar motor component Cell motility and secretion 16128509 Common ppiB peptidyl-prolyl cis-trans isomerase B (rotamase B) b0525 200 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 49176131 Common ydhF predicted oxidoreductase b1647 174 COG4989 COG4989, Predicted oxidoreductase General function prediction only 16128443 Common maa maltose O-acetyltransferase b0459 123 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 145698264 Common ydfU Qin prophage; predicted protein b1560 6 None None None 16131163 Common rimN predicted ribosome maturation factor b3282 239 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 16130123 Common rplY 50S ribosomal subunit protein L25 b2185 144 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 16130070 Common bglX beta-D-glucoside glucohydrolase, periplasmic b2132 129 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 16128854 Common cydD fused cysteine transporter subunits of ABC superfamily: membrane component/ATP-binding component b0887 248 COG4988 CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 16130530 Common rpsP 30S ribosomal subunit protein S16 b2609 212 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 16132025 Common rplI 50S ribosomal subunit protein L9 b4203 211 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 16129126 Common ycgF predicted FAD-binding phosphodiesterase b1163 145 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 94541121 Common ypeB predicted protein b4546 42 COG3530 COG3530, Uncharacterized protein conserved in bacteria Function unknown 16128257 Common yagI CP4-6 prophage; predicted DNA-binding transcriptional regulator b0272 119 COG1414 IclR, Transcriptional regulator Transcription 16130084 Common yeiT predicted oxidoreductase b2146 212 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 16130078 Common dusC tRNA-dihydrouridine synthase C b2140 208 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 16128530 Common ybcN DLP12 prophage; predicted protein b0547 5 None None None 90111307 Common ydgJ predicted oxidoreductase b1624 176 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 16130613 Common gutM DNA-binding transcriptional activator of glucitol operon b2706 12 COG4578 GutM, Glucitol operon activator Transcription 145698280 Common araH fused L-arabinose transporter subunits of ABC superfamily: membrane components b4460 141 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 16128820 Common rimK ribosomal protein S6 modification protein b0852 153 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 16131963 Common dcuA C4-dicarboxylate antiporter b4138 36 COG2704 DcuB, Anaerobic C4-dicarboxylate transporter General function prediction only 16128143 Common fhuA ferrichrome outer membrane transporter b0150 118 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 16128049 Common djlA DnaJ-like protein, membrane anchored b0055 70 COG1076 DjlA, DnaJ-domain-containing proteins 1 Posttranslational modification, protein turnover, chaperones 16130928 Common cpdA cyclic 3',5'-adenosine monophosphate phosphodiesterase b3032 83 COG1409 Icc, Predicted phosphohydrolases General function prediction only 162135896 Common ybiH predicted DNA-binding transcriptional regulator b0796 20 COG1309 AcrR, Transcriptional regulator Transcription 16129511 Common cspI Qin prophage; cold shock protein b1552 180 COG1278 CspC, Cold shock proteins Transcription 16131147 Common prmA methylase for 50S ribosomal subunit protein L11 b3259 174 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 16130491 Common era membrane-associated, 16S rRNA-binding GTPase b2566 227 COG1159 Era, GTPase General function prediction only 16128165 Common frr ribosome recycling factor b0172 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 16131029 Common kbaY tagatose 6-phosphate aldolase 1, kbaY subunit b3137 178 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 16130183 Common yfaX predicted DNA-binding transcriptional regulator b2248 117 COG1414 IclR, Transcriptional regulator Transcription 16130042 Common thiM hydoxyethylthiazole kinase b2104 77 COG2145 ThiM, Hydroxyethylthiazole kinase, sugar kinase family Coenzyme metabolism 16128196 Common yafD conserved protein b0209 31 COG3021 COG3021, Uncharacterized protein conserved in bacteria Function unknown 16128656 Common glnS glutamyl-tRNA synthetase b0680 242 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 16131369 Common yhiQ predicted SAM-dependent methyltransferase b3497 54 None None None 16131166 Common def peptide deformylase b3287 215 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 16129184 Common narL DNA-binding response regulator in two-component regulatory system with NarX (or NarQ) b1221 224 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 90111113 Common ykgG predicted transporter b0308 69 COG1556 COG1556, Uncharacterized conserved protein Function unknown 16130489 Common pdxJ pyridoxine 5'-phosphate synthase b2564 139 COG0854 PdxJ, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 16128387 Common proY predicted cryptic proline transporter b0402 154 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 90111363 Common yodB predicted cytochrome b1974 86 COG3038 CybB, Cytochrome B561 Energy production and conversion 16132088 Common idnO 5-keto-D-gluconate-5-reductase b4266 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 16131894 Common yjcH conserved inner membrane protein involved in acetate transport b4068 44 COG3162 COG3162, Predicted membrane protein Function unknown 16128986 Common pgaC predicted glycosyl transferase b1022 169 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 16129530 Common ydfA Qin prophage; predicted protein b1571 4 None None None 16129433 Common fdnG formate dehydrogenase-N, alpha subunit, nitrate-inducible b1474 185 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 16128173 Common fabZ (3R)-hydroxymyristol acyl carrier protein dehydratase b0180 188 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 16130755 Common ygeG predicted chaperone b2851 10 None None None 16132020 Common ulaF L-ribulose 5-phosphate 4-epimerase b4198 139 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 16130088 Common mglB methyl-galactoside transporter subunit b2150 91 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 94541133 Common sgcB predicted enzyme IIB component of PTS b4565 18 COG3414 SgaB, Phosphotransferase system, galactitol-specific IIB component Carbohydrate transport and metabolism 16130412 Common hyfG hydrogenase 4, subunit b2487 197 COG3261 HycE, Ni,Fe-hydrogenase III large subunit Energy production and conversion 16128890 Common mukE protein involved in chromosome partitioning b0923 20 COG3095 MukE, Uncharacterized protein involved in chromosome partitioning Cell division and chromosome partitioning 16128817 Common grxA glutaredoxin 1, redox coenzyme for ribonucleotide reductase (RNR1a) b0849 47 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 16128600 Common citD citrate lyase, acyl carrier (gamma) subunit b0617 25 COG3052 CitD, Citrate lyase, gamma subunit Energy production and conversion 90111510 Common ygfU predicted transporter b2888 130 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 16131899 Common nrfD formate-dependent nitrite reductase, membrane subunit b4073 29 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 16129569 Common fumC fumarate hydratase (fumarase C),aerobic Class II b1611 215 COG0114 FumC, Fumarase Energy production and conversion 90111282 Common bdm biofilm-dependent modulation protein b1481 4 None None None 16128572 Common fepG iron-enterobactin transporter subunit b0589 190 COG4779 FepG, ABC-type enterobactin transport system, permease component Inorganic ion transport and metabolism 49176361 Common rhsB rhsB element core protein RshB b3482 65 COG3209 RhsA, Rhs family protein Cell envelope biogenesis, outer membrane 16131331 Common yhhK conserved protein b3459 11 None None None 162135901 Common yciO conserved protein b1267 222 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 16130692 Common rumA 23S rRNA (uracil-5)-methyltransferase b2785 202 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 16128410 Common panE 2-dehydropantoate reductase, NADPH-specific b0425 107 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 16128306 Common yahG conserved protein b0321 17 None None None 90111547 Common yraR predicted nucleoside-diphosphate-sugar epimerase b3152 55 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 16128508 Common lpxH UDP-2,3-diacylglucosamine pyrophosphatase b0524 79 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 16128730 Common ybhT predicted protein b0762 6 None None None 16131778 Common metL fused aspartokinase II/homoserine dehydrogenase II b3940 236 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 145698249 Nonpathogen tpr predicted protamine-like protein b1229 1 None None None 16130749 Common yqeG predicted transporter b2845 36 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 16129334 Common tfaR Rac prophage; predicted tail fiber assembly protein b1373 15 COG5525 COG5525, Bacteriophage tail assembly protein General function prediction only 16129879 Common yedL predicted acyltransferase b1932 40 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 16131270 Common hofO conserved membrane protein b3393 6 None None None 16131218 Common tufA protein chain elongation factor EF-Tu (duplicate of tufB) b3339 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 49176368 Common ldrD toxic polypeptide, small b4453 3 None None None 16129622 Common ydhQ conserved protein b1664 26 COG3468 AidA, Type V secretory pathway, adhesin AidA Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 16129471 Common lsrR lsr operon transcriptional repressor b1512 68 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 16128799 Common gsiC predicted peptide transporter subunit: membrane component of ABC superfamily b0831 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 16131640 Common rfe UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase b3784 172 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 16128223 Common pepD aminoacyl-histidine dipeptidase (peptidase D) b0237 60 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 16130113 Common spr predicted peptidase, outer membrane lipoprotein b2175 137 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 16131077 Common ispB octaprenyl diphosphate synthase b3187 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 16130425 Common purN phosphoribosylglycinamide formyltransferase 1 b2500 221 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 16129994 Common wcaF predicted acyl transferase b2054 139 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 90111471 Nonpathogen ypjK CP4-57 prophage; predicted inner membrane protein b2635 1 None None None 145698301 Common tadA tRNA-specific adenosine deaminase b2559 217 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 16128577 Common entE 2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex b0594 222 COG1021 EntE, Peptide arylation enzymes Secondary metabolites biosynthesis, transport, and catabolism 162135904 Common dacD D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 6b) b2010 154 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 16128107 Common aceE pyruvate dehydrogenase, decarboxylase component E1, thiamin-binding b0114 155 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 16128515 Common sfmC pilin chaperone, periplasmic b0531 24 COG3121 FimC, P pilus assembly protein, chaperone PapD Cell motility and secretion / Intracellular trafficking and secretion 16128829 Common artM arginine transporter subunit b0861 170 COG4160 ArtM, ABC-type arginine/histidine transport system, permease component Amino acid transport and metabolism 90111217 Common ycfD conserved protein b1128 58 COG2850 COG2850, Uncharacterized conserved protein Function unknown 16129950 Common sbmC DNA gyrase inhibitor b2009 23 COG3449 COG3449, DNA gyrase inhibitor DNA replication, recombination, and repair 16130394 Common narQ sensory histidine kinase in two-component regulatory system with NarP (NarL) b2469 121 COG3850 NarQ, Signal transduction histidine kinase, nitrate/nitrite-specific Signal transduction mechanisms 145698328 Nonpathogen tisA lexA-regulated predicted protein b4617 1 None None None 16129057 Common acpP acyl carrier protein (ACP) b1094 182 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 16131391 Common treF cytoplasmic trehalase b3519 30 COG1626 TreA, Neutral trehalase Carbohydrate transport and metabolism 16132063 Common treR DNA-binding transcriptional repressor b4241 125 COG1609 PurR, Transcriptional regulators Transcription 16128560 Common ybdG predicted mechanosensitive channel b0577 95 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 16129525 Nonpathogen flxA Qin prophage; predicted protein b1566 1 None None None 90111647 Common rbsD predicted cytoplasmic sugar-binding protein b3748 44 COG1869 RbsD, ABC-type ribose transport system, auxiliary component Carbohydrate transport and metabolism 16131356 Common yhhI predicted transposase b3484 34 COG5433 COG5433, Transposase DNA replication, recombination, and repair 90111155 Common ybeF predicted DNA-binding transcriptional regulator b0629 99 COG0583 LysR, Transcriptional regulator Transcription 16129447 Common ddpX D-ala-D-ala dipeptidase, Zn-dependent b1488 59 COG2173 DdpX, D-alanyl-D-alanine dipeptidase Cell envelope biogenesis, outer membrane 16129690 Common chbA N,N'-diacetylchitobiose-specific enzyme IIA component of PTS b1736 32 COG1447 CelC, Phosphotransferase system cellobiose-specific component IIA Carbohydrate transport and metabolism 16128865 Common ycaD predicted transporter b0898 101 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 16131221 Common rpsL 30S ribosomal subunit protein S12 b3342 242 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 16131988 Common yjeS predicted Fe-S electron transport protein b4166 137 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 16129755 Common yeaV predicted transporter b1801 96 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 16129893 Common fliN flagellar motor switching and energizing component b1946 124 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 16131138 Common mreC cell wall structural complex MreBCD transmembrane component MreC b3250 124 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 16128445 Common ybaJ predicted protein b0461 10 None None None 16129781 Common kdgR predicted DNA-binding transcriptional regulator b1827 124 COG1414 IclR, Transcriptional regulator Transcription 16129590 Common rsxE predicted inner membrane NADH-quinone reductase b1632 76 COG4660 RnfE, Predicted NADH:ubiquinone oxidoreductase, subunit RnfE Energy production and conversion 16131811 Common secE preprotein translocase membrane subunit b3981 68 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 16128737 Common ybhH conserved protein b0769 56 COG2828 COG2828, Uncharacterized protein conserved in bacteria Function unknown 16131654 Common hemY predicted protoheme IX synthesis protein b3802 46 COG3071 HemY, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 16128056 Common araA L-arabinose isomerase b0062 35 COG2160 AraA, L-arabinose isomerase Carbohydrate transport and metabolism 16132110 Common fecC KpLE2 phage-like element; iron-dicitrate transporter subunit b4289 189 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 16129113 Common ymfR e14 prophage; predicted protein b1150 3 None None None 90111440 Common eutS predicted carboxysome structural protein with predicted role in ethanol utilization b2462 20 COG4810 EutS, Ethanolamine utilization protein Amino acid transport and metabolism 90111563 Common rng ribonuclease G b3247 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 16128012 Common mokC regulatory protein for HokC, overlaps CDS of hokC b0018 7 None None None 16129699 Common astB succinylarginine dihydrolase b1745 34 COG3724 AstB, Succinylarginine dihydrolase Amino acid transport and metabolism 16129616 Common purR DNA-binding transcriptional repressor, hypoxanthine-binding b1658 129 COG1609 PurR, Transcriptional regulators Transcription 16131412 Common dppF dipeptide transporter b3540 249 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 16129454 Common yddB predicted porin protein b1495 16 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 16130215 Common nuoJ NADH:ubiquinone oxidoreductase, membrane subunit J b2280 90 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 16131845 Common metH homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent b4019 180 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 16131192 Common rplP 50S ribosomal subunit protein L16 b3313 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 16131101 Common yhcC predicted Fe-S oxidoreductase b3211 86 COG1242 COG1242, Predicted Fe-S oxidoreductase General function prediction only 90111708 Common chpS antitoxin of the ChpB-ChpS toxin-antitoxin system b4224 20 COG2336 MazE, Growth regulator Signal transduction mechanisms 16131851 Common pgi glucosephosphate isomerase b4025 198 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 16128121 Common yadH predicted transporter subunit: membrane component of ABC superfamily b0128 137 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 16131608 Common gidB methyltransferase, SAM-dependent methyltransferase, glucose-inhibited cell-division protein b3740 202 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 16128556 Common cusF periplasmic copper-binding protein b0573 29 COG5569 COG5569, Uncharacterized conserved protein Function unknown 16128917 Common pqiA paraquat-inducible membrane protein A b0950 56 COG2995 PqiA, Uncharacterized paraquat-inducible protein A Function unknown 16129837 Common tap methyl-accepting protein IV b1885 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 16132125 Common sgcC KpLE2 phage-like element; predicted phosphotransferase enzyme IIC component b4304 19 COG3775 GatC, Phosphotransferase system, galactitol-specific IIC component Carbohydrate transport and metabolism 16129562 Common ydgH predicted protein b1604 11 None None None 16128718 Common nadA quinolinate synthase, subunit A b0750 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 16128275 Common yagW predicted receptor b0290 4 None None None 90111452 Common sseB rhodanase-like enzyme, sulfur transfer from thiosulfate b2522 13 None None None 16132186 Common yjjQ predicted DNA-binding transcriptional regulator b4365 15 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 90111174 Common fsaA fructose-6-phosphate aldolase 1 b0825 109 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 16129238 Common ribA GTP cyclohydrolase II b1277 193 COG0807 RibA, GTP cyclohydrolase II Coenzyme metabolism 16131281 Common envZ sensory histidine kinase in two-component regulatory system with OmpR b3404 216 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 16131926 Common phnH carbon-phosphorus lyase complex subunit b4100 42 COG3625 PhnH, Uncharacterized enzyme of phosphonate metabolism Inorganic ion transport and metabolism 90111447 Common hyfR DNA-binding transcriptional activator, formate sensing b2491 169 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 16128725 Common galK galactokinase b0757 91 COG0153 GalK, Galactokinase Carbohydrate transport and metabolism 16128681 Common ybfD conserved protein b0706 30 COG5433 COG5433, Transposase DNA replication, recombination, and repair 49176411 Common rffG dTDP-glucose 4,6-dehydratase b3788 231 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 16128426 Common ppiD peptidyl-prolyl cis-trans isomerase (rotamase D) b0441 161 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 16128618 Common mrdA transpeptidase involved in peptidoglycan synthesis (penicillin-binding protein 2) b0635 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 16131021 Common sohA predicted regulator b3129 11 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 16130178 Common glpC sn-glycerol-3-phosphate dehydrogenase (anaerobic), small subunit b2243 179 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 16130795 Common dsbC protein disulfide isomerase II b2893 66 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 16131799 Common oxyR DNA-binding transcriptional dual regulator b3961 192 COG0583 LysR, Transcriptional regulator Transcription 16129903 Common yodC predicted protein b1957 5 COG5475 COG5475, Uncharacterized small protein Function unknown 90111332 Common yoaI predicted protein b1788 2 None None None 16131296 Common rtcR sigma 54-dependent transcriptional regulator of rtcBA expression b3422 162 COG4650 RtcR, Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain Transcription / Signal transduction mechanisms 16130372 Nonpathogen yffP CPZ-55 prophage; predicted protein b2447 1 None None None 16130964 Common mug G/U mismatch-specific DNA glycosylase b3068 29 COG3663 Mug, G:T/U mismatch-specific DNA glycosylase DNA replication, recombination, and repair 16128754 Common ybhL predicted inner membrane protein b0786 124 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 16128860 Common serS seryl-tRNA synthetase, also charges selenocysteinyl-tRNA with serine b0893 244 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 16131108 Common insH IS5 transposase and trans-activator b3218 37 COG3039 COG3039, Transposase and inactivated derivatives, IS5 family DNA replication, recombination, and repair 16128721 Common ybgS conserved protein b0753 6 None None None 16128363 Common yaiW predicted DNA-binding transcriptional regulator b0378 18 None None None 90111187 Common ycaI conserved inner membrane protein b0913 131 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 16128265 Nonpathogen yagN CP4-6 prophage; predicted protein b0280 1 None None None 90111657 Common hemN coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-independent b3867 204 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 90111652 Common yigI conserved protein b3820 48 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 16127996 Common thrA fused aspartokinase I and homoserine dehydrogenase I b0002 236 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 16131092 Common rpoN RNA polymerase, sigma 54 (sigma N) factor b3202 145 COG1508 RpoN, DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog Transcription 16130984 Common sstT sodium:serine/threonine symporter b3089 106 COG3633 SstT, Na+/serine symporter Amino acid transport and metabolism 16128095 Common yacF conserved protein b0102 44 COG4582 COG4582, Uncharacterized protein conserved in bacteria Function unknown 16132036 Common cysQ PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase b4214 178 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 16130653 Common ispF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase b2746 187 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 16130995 Common yqjK conserved protein b3100 9 None None None 16131979 Common frdA fumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit b4154 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 16130625 Common hycH protein required for maturation of hydrogenase 3 b2718 13 None None None 90111407 Common yfaZ predicted outer membrane porin protein b2250 13 None None None 16129914 Common yedV predicted sensory kinase in two-component regulatory system with YedW b1968 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 145698304 Common yfjD predicted inner membrane protein b4461 218 COG4536 CorB, Putative Mg2+ and Co2+ transporter CorB Inorganic ion transport and metabolism 16129872 Common fliS flagellar protein potentiates polymerization b1925 83 COG1516 FliS, Flagellin-specific chaperone FliS Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 16130065 Common mlrA DNA-binding transcriptional regulator b2127 54 COG0789 SoxR, Predicted transcriptional regulators Transcription 49176302 Common ygiQ conserved protein b4469 73 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 16128088 Common ftsZ GTP-binding tubulin-like cell division protein b0095 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 16131583 Common yieH predicted hydrolase b3715 145 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 16132171 Common hsdR endonuclease R b4350 96 COG4096 HsdR, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 16129953 Common yeeD conserved protein b2012 15 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 145698289 Common nuoN NADH:ubiquinone oxidoreductase, membrane subunit N b2276 210 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 16131884 Common uvrA ATPase and DNA damage recognition protein of nucleotide excision repair excinuclease UvrABC b4058 240 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 16131179 Common secY preprotein translocase membrane subunit b3300 225 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 16131265 Common dam DNA adenine methylase b3387 98 COG0338 Dam, Site-specific DNA methylase DNA replication, recombination, and repair 16130972 Common ebgC cryptic beta-D-galactosidase, beta subunit b3077 9 COG2731 EbgC, Beta-galactosidase, beta subunit Carbohydrate transport and metabolism 16129593 Common gst glutathionine S-transferase b1635 84 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 16131364 Common yhiN predicted oxidoreductase with FAD/NAD(P)-binding domain b3492 136 COG2081 COG2081, Predicted flavoproteins General function prediction only 16131234 Common prkB predicted phosphoribulokinase b3355 52 COG3954 PrkB, Phosphoribulokinase Energy production and conversion 16130324 Common mntH manganese/divalent cation transporter b2392 110 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 90111513 Common ygfI predicted DNA-binding transcriptional regulator b2921 97 COG0583 LysR, Transcriptional regulator Transcription 16131255 Common yhfT predicted inner membrane protein b3377 11 COG3851 UhpB, Signal transduction histidine kinase, glucose-6-phosphate specific Signal transduction mechanisms 16130424 Common purM phosphoribosylaminoimidazole synthetase b2499 232 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 16130352 Common yfeT predicted DNA-binding transcriptional regulator b2427 120 COG1737 RpiR, Transcriptional regulators Transcription 16129240 Common yciS conserved inner membrane protein b1279 21 COG3771 COG3771, Predicted membrane protein Function unknown 16128384 Common phoB DNA-binding response regulator in two-component regulatory system with PhoR (or CreC) b0399 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 49176351 Common malP maltodextrin phosphorylase b3417 130 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 16129477 Common lsrG autoinducer-2 (AI-2) modifying protein LsrG b1518 25 COG1359 COG1359, Uncharacterized conserved protein Function unknown 16130824 Common argO arginine transporter b2923 84 COG1279 COG1279, Lysine efflux permease General function prediction only 16129514 Common ydfR Qin prophage; predicted protein b1555 3 None None None 16128859 Common rarA recombination protein b0892 240 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 16129847 Common uspC universal stress protein b1895 28 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 16130709 Common fucI L-fucose isomerase b2802 19 COG2407 FucI, L-fucose isomerase and related proteins Carbohydrate transport and metabolism 16128581 Common cstA carbon starvation protein b0598 109 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 90111597 Common yhhT predicted inner membrane protein b3474 194 COG0628 PerM, Predicted permease General function prediction only 16128626 Common ybeL conserved protein b0643 22 None None None 16130737 Common ygdR predicted protein b2833 14 None None None 16129382 Common ydcJ conserved protein b1423 23 COG5383 COG5383, Uncharacterized protein conserved in bacteria Function unknown 16131048 Common yhbS predicted acyltransferase with acyl-CoA N-acyltransferase domain b3156 93 COG3153 COG3153, Predicted acetyltransferase General function prediction only 90111130 Common yajO 2-carboxybenzaldehyde reductase, function unknown b0419 205 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 16131454 Common sgbE L-ribulose-5-phosphate 4-epimerase b3583 109 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 16130900 Common yqhA conserved inner membrane protein b3002 55 COG2862 COG2862, Predicted membrane protein Function unknown 16128634 Common rihA ribonucleoside hydrolase 1 b0651 88 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 16130801 Common yqfA predicted oxidoreductase, inner membrane subunit b2899 119 COG1272 COG1272, Predicted membrane protein, hemolysin III homolog General function prediction only 16131504 Common waaA 3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase) b3633 128 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 16131970 Common yjeJ predicted protein b4145 5 None None None 90111269 Common ydcI predicted DNA-binding transcriptional regulator b1422 192 COG0583 LysR, Transcriptional regulator Transcription 16128470 Common ybaT predicted transporter b0486 126 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 16132145 Common uxuR DNA-binding transcriptional repressor b4324 138 COG2186 FadR, Transcriptional regulators Transcription 49176441 Common rhaA L-rhamnose isomerase b3903 23 COG4806 RhaA, L-rhamnose isomerase Carbohydrate transport and metabolism 49176479 Common yjgM predicted acetyltransferase b4256 45 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 16129807 Common pykA pyruvate kinase II b1854 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 16128692 Common ybgP predicted assembly protein b0717 24 COG3121 FimC, P pilus assembly protein, chaperone PapD Cell motility and secretion / Intracellular trafficking and secretion 90111582 Common hofP predicted protein b3392 6 None None None 90111611 Common eptB predicted metal dependent hydrolase b3546 63 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 90111728 Common nanC N-acetylnuraminic acid outer membrane channel protein b4311 10 None None None 90111526 Common yqhC predicted DNA-binding transcriptional regulator b3010 136 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 16128234 Common ykfF CP4-6 prophage; predicted protein b0249 4 None None None 90111668 Common gldA glycerol dehydrogenase, NAD b3945 115 COG0371 GldA, Glycerol dehydrogenase and related enzymes Energy production and conversion 16129149 Common nhaB sodium:proton antiporter b1186 31 COG3067 NhaB, Na+/H+ antiporter Inorganic ion transport and metabolism 16128958 Common yccM predicted 4Fe-4S membrane protein b0992 111 COG0348 NapH, Polyferredoxin Energy production and conversion 16130588 Common nrdI protein that stimulates ribonucleotide reduction b2674 39 COG1780 NrdI, Protein involved in ribonucleotide reduction Nucleotide transport and metabolism 49176391 Common dgoA 2-oxo-3-deoxygalactonate 6-phosphate aldolase b4477 117 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 16131953 Common yjdJ predicted acyltransferase with acyl-CoA N-acyltransferase domain b4127 22 COG2388 COG2388, Predicted acetyltransferase General function prediction only 16128026 Common carA carbamoyl phosphate synthetase small subunit, glutamine amidotransferase b0032 235 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 16129681 Common yniC predicted hydrolase b1727 170 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 16131200 Common rpsJ 30S ribosomal subunit protein S10 b3321 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 16130019 Common baeR DNA-binding response regulator in two-component regulatory system with BaeS b2079 211 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 16128898 Common pncB nicotinate phosphoribosyltransferase b0931 101 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 16128684 Common ybgH predicted transporter b0709 82 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 16130841 Common yqgC predicted protein b2940 3 None None None 16129799 Common yebE conserved protein b1846 32 COG2979 COG2979, Uncharacterized protein conserved in bacteria Function unknown 90111244 Common puuA gamma-Glu-putrescine synthase b1297 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 16131696 Common hemG protoporphyrin oxidase, flavoprotein b3850 37 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 90111294 Common ynfN Qin prophage; predicted protein b1551 1 None None None 145698334 Common yihA GTP-binding protein b3865 181 COG0218 COG0218, Predicted GTPase General function prediction only 90111262 Common uspF stress-induced protein, ATP-binding protein b1376 81 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 90111253 Common ydaM predicted diguanylate cyclase, GGDEF domain signalling protein b1341 184 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 16129261 Common puuC gamma-Glu-gamma-aminobutyraldehyde dehydrogenase, NAD(P)H-dependent b1300 221 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 16130106 Common fruK fructose-1-phosphate kinase b2168 106 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 162135918 Common recQ ATP-dependent DNA helicase b3822 238 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 16129215 Common yciB predicted inner membrane protein b1254 85 COG2917 COG2917, Intracellular septation protein A Cell division and chromosome partitioning 16128833 Common ybjP predicted lipoprotein b0865 9 None None None 16130386 Common eutP conserved protein with nucleoside triphosphate hydrolase domain b2461 18 COG4917 EutP, Ethanolamine utilization protein Amino acid transport and metabolism 16128824 Common potH putrescine transporter subunit: membrane component of ABC superfamily b0856 210 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 16128085 Common ddlB D-alanine:D-alanine ligase b0092 219 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 16128805 Common yliI predicted dehydrogenase b0837 119 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 16129468 Common ydeU conserved protein b1509 25 COG3468 AidA, Type V secretory pathway, adhesin AidA Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 16131744 Common rhaB rhamnulokinase b3904 105 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 16128756 Common ybhN conserved inner membrane protein b0788 56 COG0392 COG0392, Predicted integral membrane protein Function unknown 16130506 Common yfiF predicted methyltransferase b2581 213 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 16129305 Common ttcA predicted C32 tRNA thiolase b1344 164 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 16128079 Common murF UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase b0086 208 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 16130026 Common yegS phosphatidylglycerol kinase, metal-dependent b2086 81 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 16130893 Common hybD predicted maturation element for hydrogenase 2 b2993 79 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 16131991 Common amiB N-acetylmuramoyl-l-alanine amidase II b4169 165 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 16128848 Common cspD cold shock protein homolog b0880 176 COG1278 CspC, Cold shock proteins Transcription 16130581 Common ygaV predicted DNA-binding transcriptional regulator b2667 83 COG0640 ArsR, Predicted transcriptional regulators Transcription 16128679 Common ybfC predicted protein b0704 1 None None None 90111400 Common yeiU undecaprenyl pyrophosphate phosphatase b2174 15 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 90111192 Common ycbF predicted periplasmic pilini chaperone b0944 22 COG3121 FimC, P pilus assembly protein, chaperone PapD Cell motility and secretion / Intracellular trafficking and secretion 16130591 Common proV glycine betaine transporter subunit b2677 249 COG4175 ProV, ABC-type proline/glycine betaine transport system, ATPase component Amino acid transport and metabolism 16129423 Common yddE conserved protein b1464 121 COG0384 COG0384, Predicted epimerase, PhzC/PhzF homolog General function prediction only 49176309 Common ygjI predicted transporter b3078 46 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 16128374 Common yaiA predicted protein b0389 8 None None None 16129658 Common pps phosphoenolpyruvate synthase b1702 235 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 90111689 Common yjdC predicted transcriptional regulator b4135 33 COG1309 AcrR, Transcriptional regulator Transcription 16131205 Common gspE general secretory pathway component, cryptic b3326 218 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 90111274 Common ydcX predicted inner membrane protein b1445 8 None None None 90111091 Common ligT 2'-5' RNA ligase b0147 86 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 16128591 Common ybdR predicted oxidoreductase, Zn-dependent and NAD(P)-binding b0608 208 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 16130534 Common nadK NAD kinase b2615 240 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 16130925 Common ygiN quinol monooxygenase b3029 15 COG1359 COG1359, Uncharacterized conserved protein Function unknown 49176286 Common tktA transketolase 1, thiamin-binding b2935 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 16131667 Common yigF conserved inner membrane protein b3817 8 None None None 16129802 Common purT phosphoribosylglycinamide formyltransferase 2 b1849 197 COG0027 PurT, Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) Nucleotide transport and metabolism 90111622 Common htrL predicted protein b3618 3 None None None 16128670 Common kdpE DNA-binding response regulator in two-component regulatory system with KdpD b0694 211 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 90111199 Nonpathogen gfcA predicted protein b0987 1 None None None 90111682 Common nrfB nitrite reductase, formate-dependent, penta-heme cytochrome c b4071 18 COG3303 NrfA, Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit Inorganic ion transport and metabolism 16129255 Common sapA predicted antimicrobial peptide transporter subunit b1294 201 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 90111424 Common yfdR CPS-53 (KpLE1) prophage; conserved protein b2361 26 COG1896 COG1896, Predicted hydrolases of HD superfamily General function prediction only 16129754 Common yeaU predicted dehydrogenase b1800 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 16129121 Common pinE e14 prophage; site-specific DNA recombinase b1158 144 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair